The H3K27, H3K36, and DNAme interaction network. (A) The principal interaction network in mESCs, with the central role of H3K36me2. The dashed line represents the weaker influence of the DNAme-H3K27me axis; however, the relative strengths of those interactions may differ across cell types. (B) Molecular cartoon illustrating the state of this three-component system across five distinct genomic compartments and showing how disturbing each of the components affects the system.