The genomic inflation assessment for POKEMON shows that POKEMON is less prone to population stratification than the frequency test. The genomic inflation is calculated for both approximately 2000 genes with available Protein Data Bank (PDB) structures and about 12,000 with available AlphaFold2 structures. The phenotype is simulated with varying percentages of subjects with genetic ancestry–matched phenotype. The results for frequency tests in the dashed lines are calculated with the same genes with available PDB structures or available AlphaFold2 structures.