Derivation of extremities and novel adjacencies for input to RCK and ReMixT. (A) An example of derivation of coordinates that resembles a reciprocal signature in measured unlabeled novel adjacencies on a chromosome a. Positions p₁ = (a, 100, + ) and p₂ = (a, 107, − ) have reciprocal signature (i.e., $|\mathrm{coor}{\mathrm{d}}_1-\mathrm{coor}{\mathrm{d}}_2|=7<50$ and $\mathrm{st}{\mathrm{r}}_1=-\ne \mathrm{st}{\mathrm{r}}_2=+$). Updated pair $\left\{{p^{\mathrm{\prime }}}_1=\left(a,103,+\right),{p^{\mathrm{\prime }}}_2=\left(a,104,-\right)\right\}$ of coordinates constitutes a reciprocal location. (B) An example of partitioning of a set $\mathcal{F}=\left\{f_1,f_2,f_3,f_4\right\}$ of fragments from allele-specific copy number calls into a set S = {s₁, s₂, s₃, s₄, s₅, s₆, s₇, s₈} of segments. Extremities of segments in S correspond to either preprocessed coordinates of unlabeled novel adjacencies (e.g., $s_1^h=p_1^{\mathrm{\prime }}$,$s_2^t=p_2^{\mathrm{\prime }}$) or to the extremities of fragments in F (e.g., $s_3^h=f_2^h$,$s_4^t=f_3^t$).