Summary of the similarities and differences between the lincRNA and mRNA life cycles. (A,B) LincRNAs have fewer histone marks (A) and transcription factors (B) bound in their promoter than mRNAs. (C) U1 motif profiles are similar in lincRNAs and mRNAs. (D) Splicing efficiency is lower in lincRNAs than in mRNAs and lincRNAs are depleted for U2AF65-binding. (E) LincRNA and mRNA stability is similar when comparing expression-matched groups. HuR binds equally to both classes but is biased toward 3′ UTR localization in mRNAs alone.