Copy-number variants (CNVs) are associated with the formation of new domain boundaries in cancer cells. CNV regions visualized as relative copy-number estimates for each cell type (presented in green) are aligned with chromatin interaction heat maps (presented as normalized interaction counts visualized in WashU Epigenome Browser) and TADs, demonstrating that cancer-specific domain boundaries are located at regions of CNVs in cancer cell lines. The location of RefSeq genes in the region of copy-number variation is indicated below. An example from Chromosome 17 is shown, where a 400- to 600-kb deletion encompassing the TP53 locus that is present in both cancer cell lines is associated with establishment of a new domain boundary and a resulting change in local interactions across this region.