Seasonal regulatory (transcriptomics and proteomics) changes in the shrew liver. (A) Volcano plots of significant (P_adj < 0.05) differentially expressed genes and proteins (colored) for summer versus winter juvenile comparisons. Triangles represent lower P-values (−log(P) > 10) or log fold changes (abs(LFC) > 4) beyond the limits of the graph. Correlation of log fold change and significant gene overlap between RNA and protein indicates high association between multiomic comparisons (R² = 0.13). (B) Although volcano plots of significant differentially expressed genes and proteins for winter juveniles versus spring adult were identified, multiomic correlation was low in comparison to the shrinking phase (R² = 0.02).