Somatic mutation portraits in the chondrosarcoma genome. (A) Frequencies of 96 mutation portraits (combination of immediate 5′ and 3′ bases with six substitutions) in peripheral (CS1T) and central (CS2T and CS5T) cases. Sixteen triplet sequence patterns (mutations with immediate 5′ and 3′ nucleotides) for each substitution are indicated by different color columns. (B) Frequencies of 96 mutation portraits in chondrosarcoma (average), prostate cancer (average), UV-associated melanoma, and smoking-associated lung cancer genomes.