Comparison of isoform specificities. DNA-binding specificities of 17 Lola isoforms generated through alternate splicing. MatAlign clustergram emphasizing the diversity within the recognition motifs of the various Lola isoforms. All of the characterized ZFPs utilize a pair of zinc fingers to recognize DNA. Identical fingers are present in the lola-PN and -PY isoforms and the lola-PT and -PU isoforms, and both pairs have identical specificity.