Effects of MED19 and HIPK2 depletion on gene expression in LNCaP-abl cells. (A) Depiction of the procedure used to examine MED19 and HIPK2-responsive genes. (B) Number of genes up-regulated and down-regulated by >1.5-fold upon MED19 and HIPK2 depletion in LNCaP-abl cells. (C) Numbers of genes in MED19 and HIPK2 siRNA-depleted LNCaP-abl cells that overlap with siRNA knockdown of AR in LNCaP-abl cells. (D) Microarray heat map of changes in gene expression in LNCaP-abl cells depleted of HIPK2, MED19, AR, and parental LNCaP cells depleted of AR siRNA. (E) Gene Ontology analysis of the genes affected by siRNA depletion of the indicated factor in LNCaP-abl cells. (*) The data sets for LNCaP siAR, LNCaP-abl siAR were taken from Gene Expression Omnibus accession numbers GSE7868 and GSE11428 (Wang et al. 2009).