FAIRE-seq and MAINE-seq coverage in centromeric and telomeric/subtelomeric regions. Mean depths of read coverage in centromeres (A) and telomeres (B) were compared with the mean depth of read coverage genome-wide (MAINE-seq, red; FAIRE-seq, black) and displayed as a log₂ scale. (A) Centromeres are depleted in nucleosomes relative to the rest of the genome. (B) Nucleosomes are consistently more abundant in telomeres than in the rest of the genome. Coding regions of the telomeres are densely packed compared with possible regulatory regions (classically located outside the genes) and other noncoding regions.