Breakpoint at end of LCR22-2 is in AT-rich sequence. The image above shows the distal end of LCR22–2 (boxed) on chromosome 22q11.2 present in the genomic clone, AC008103. The DGCR6 gene is adjacent to the LCR22. The repetitive element track, showing LINEs, SINEs, AT-rich repeats, and HSAT I elements, adapted from the UCSC Browser genome assembly (http://genome.ucsc.edu/) is shown. The precise end of LCR22-2 is located within an AT-rich repeat. The sequences at the breakpoint are shown, with the unique sequence to the right of the AT-rich repeat. The position of the breakpoint is boxed. The chromosomal region containing LCR22-4 is shown below the respective region of LCR22-2. The genomic clone, AP000552 spans the interval. Similarly, the repetitive sequences are shown below the clone, with the position of the breakpoint, as boxed. Data are consistent with a breakpoint in the AT-rich repeat, within LCR22-4, resulting in the formation of LCR22-2.