Comparison of gene expression between daf-2 and control worms on day 6
Gene family | Gene name | Biological function | Mean fold increasea | P-value | |
| Stress response | |||||
| hsp-16 genes | hsp-16.48, -16.49b | 31.2 | 5.7E-40 | ||
| hsp-16.1, -16.11b,c | 1.8 | 6.0E-03 | |||
| hsp-16.2c | Heat shock protein | 142.3 | 4.2E-29 | ||
| hsp-16.41 | 12.1 | 1.9E-21 | |||
| hsp-12 gene | hsp-12.6c,d | 65.3 | 1.3E-15 | ||
| tts transcript | tts-1 | Transcribed telomere-like sequence | 21.4 | 8.9E-232 | |
| Protein metabolism | |||||
| Ribosomal proteins | rpl-43, rpl-20, rpl-29, rpl-30, rpl-23, rpl-31, rpl-35, rpl-8, rpl-27, rpl-22, rps-11, rps-13, rps-7, rps-17, rps-0, rpa-1, Y105E8A. 16, M28.5, Y48G8AL.8a, Y41D4B.5 | 2.8 | 1.9E-03 | ||
| Cellular signaling | |||||
| Transthyretin-like proteins | ZK697.8, F22A3.2, ZC64.2, C40H1.5c, Y5F2A.2, Y51A2D.10 | Signaling and transport | 7.1 | 1.2E-03 | |
| nlp genes | nlp-27, nlp-28, nlp-29, nlp-31 | Neuropeptide-like protein | 8.2 | 9.2E-05 | |
| Gene family | Gene name | Biological function | Mean fold decreasea | P-value | |
| Lipid metabolism | |||||
| Vitellogenins | vit-4c | Lipid transport | 39.3 | 1.3E-12 | |
| vit-1, vit-2b,c,d | 385.1 | 8.5E-115 | |||
| vit-3, vit-5b,c,d | 100.9 | 4.6E-32 | |||
| vit-6d | 122.4 | 2.2E-37 | |||
| Stress response | |||||
| Cold shock | cey-1, cey-2, cey-3 | Cold-shock DNA-binding domain | 15.1 | 4.3E-06 | |
| Structure | |||||
| Tubulin genes | tbg-1, tbb-1, tbb-2, tba-2 | Microtubule-based movement | 30.1 | 4.5E-08 | |
| Actin genes | act-1, act-2, act-3, act-4, act-5d | Cytoskeleton organization | 26.6 | 5.0E-06 | |
| DNA/RNA metabolism | |||||
| Pumilio genes | puf-3d, puf-5 | RNA binding protein | 19.6 | 4.4E-06 | |
| puf-10, puf-6, puf-7b | 19.6 | 1.7E-06 | |||
| mcm genes | mcm-2, mcm-3, mcm-4, mcm-5, mcm-6 | Initiation of DNA replication | 19.4 | 1.1E-03 | |
| Protein metabolism | |||||
| asp genes | asp-1, asp-2, asp-6b,d, asp-3c, asp-4, asp-5 | Proteolysis and peptidolysis | 8.4 | 4.1E-02 | |
| spp genes | spp-1, ssp-10, spp-14 | 3.2 | 6.6E-02 | ||
| rpn genes | rpn-2, rpn-8, rpn-9, rpn-11 | Proteasome regulatory particle | 8.1 | 2.3E-03 | |
| eft genes | eft-2, eft-3, eft-4 | Translation elongation | 28.2 | 3.2E-14 | |
| F17C11.9a, Y41E3.10 | 5.9 | 5.7E-03 | |||
| cct genes | cct-1, cct-4, cct-6 | Cytosolic chaperone activity | 6.3 | 7.2E-04 | |
a Fold increase or decrease calculated using tag frequencies.
b Genes listed in the same line are closely related and cannot be distinguished by means of their SAGE tags. In these cases the tag numbers indicated are the sum of the tags for both or all genes on that line.
c Overlap with Murphy et al. (2003).
d Overlap with McElwee et al. (2003).