Estimates of evolutionary constraint in CNGs and their 3′ and 5′ 1000-base flanking sequences in hominids and murids
Species comparison | Sequence category | Constraint (SE) |
|---|---|---|
| Human-chimp | CNGS | 0.293 (0.020) |
| 5′- and 3′-flanks | 0.0502 (0.011) | |
| Mouse-rat | CNGs | 0.529 (0.0081) |
| 5′ and 3′-flanks | 0.0970 (0.008) |
[i] Constraint is estimated from 1 - ΣO/ΣE, where O is the observed number of substitutions in a sequence and E is the number expected based on the number of substitutions in flanking sequences 3-10 kb upstream and downstream from each CNG. These flanking sequences exclude other CNGs and their flanks, and coding sequences. The summations are over CNGs. See Methods for details.