The Functional Signatures of the Primary Groups
GO Term Name | # Overlapping | Genes in Term | Significance C/E | Significance E |
|---|---|---|---|---|
| Group 1 C/E >2 (2620) | ||||
| Structural proteins | 316 | 1576 | 1.21E-11 | 3.94E-10 |
| Plasma membrane | 247 | 1192 | 3.15E-10 | 1.56E-08 |
| Transporter | 268 | 1462 | 2.04E-05 | 1.13E-05 |
| Metabolism | 168 | 856 | 2.32E-05 | 4.84E-05 |
| Signal transduction | 525 | 1142 | 2.06E-04 | 7.00E-03 |
| Transcription factor | 154 | 856 | 1.44E-02 | 1.56E-02 |
| DNA repair | 13 | 106 | 1.90E-02 | — |
| Wnt receptor signaling* | 5 | 12 | 6.72E-03 | — |
| Group 2 C/E <0.5 (1493) | ||||
| Ribosome | 59 | 139 | 6.11E-24 | 4.88E-19 |
| RNA binding | 72 | 374 | 5.53E-08 | 1.02E-02 |
| Cytosol | 51 | 226 | 9.44E-08 | 1.02E-03 |
| Mitochondrial | 65 | 459 | 1.78E-02 | — |
| Cell motility* | 10 | 108 | 9.56E-03 | — |
| Group 3 C/E <2 to >0.5 (3842) | ||||
| Signal transduction | 252 | 1142 | 2.54E-82 | — |
| Serine threonine kinase | 29 | 245 | 4.93E-10 | — |
| Proliferation | 32 | 426 | 4.17E-06 | — |
| Cell adhesion | 31 | 445 | 4.03E-05 | — |
| Cell cycle regulators | 22 | 365 | 4.20E-03 | — |
| Nucleic acid binding | 67 | 1925 | 8.50E-04 | — |
[i] The Gene Ontology term names of the primary functional groups represented by the three major groups are shown. The number of genes that overlap with the term and the total number of genes in the term are shown for comparison. The significance value of the calculated relationship for each term from the combined data set and from the expression data alone is given next. Terms with — in the last column could not be found by expression alone. Significance was calculated from the overlap of the master list to the test list, and tested using a Bonferroni-corrected hypergeometric distribution to determine a confidence value to reject the null hypothesis. Terms with asterisks were not identified as dominant terms in the initial search, but were found to be dominate subterms in that set.