Correlation Between Synonymous Substitution Rate (K4) and Expression Breadth
Human—mouse | Mouse—rat | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Breadth measurea | rb | P | N | rb | P | N | ||||
| All genes | ||||||||||
| EST | -0.203 | <0.00001 | 1247 | -0.063 | 0.00088 | 2759 | ||||
| SAGE | -0.125 | 0.00007 | 1057 | -0.088 | <0.00001 | 2579 | ||||
| Microarray | -0.187 | 0.00003 | 596 | -0.057 | 0.0237 | 1592 | ||||
| GC≤0.5 | ||||||||||
| EST | -0.341 | <0.00001 | 322 | -0.165 | 0.00011 | 570 | ||||
| SAGE | -0.242 | 0.00011 | 260 | -0.202 | <0.00001 | 565 | ||||
| Microarray | -0.339 | 0.00002 | 148 | -0.090 | 0.098 | 340 | ||||
a Breadth of expression was averaged over experiments in human and mouse for the human—mouse comparison, and was obtained from mouse only in the mouse—rat comparison.
b Pearson's correlation coefficient between expression breadth and K4. Only nondisparate gene pairs were included.