Heaviest bundling of Hs.2012. (A) Heaviest bundling algorithm (see text). (B) Heaviest bundling produces four maximum likelihood traversals of the Hs.2012 splice graph, each highlighted in red. Numbered nodes represent the exon forms; arrows represents splices between exons. The starting template sequence used for each heaviest bundle is indicated by thick outlines on the nodes that constitute its exons (see text).