Examples of Functional Categories Found to be Transcriptionally Enriched in the Samples of Genes Under- and Overexpressed in Hybrid Females of D. melanogaster and D. simulans
Functional category (GMRC terma, P valueb) | |
|---|---|
| Underexpressed Genes | |
| Metabolic and Regulatory Pathway | Transcription factors (dme03022; P = 2.9 × 10-3) |
| Molecular Function | Nucleic acid binding activity (GO:0003676; P = 6.6 × 10-13) |
| RNA binding activity (GO:0003723; P = 4.6 × 10-4) | |
| Helicase activity (GO:0004386; P = 3.3 × 10-2) | |
| Biological Process | DNA metabolism (GO:0006259; P = 1.1 × 10-9) |
| Cell growth and/or maintenance (GO:0008151; P = 8.8 × 10-7) | |
| Transcription (GO:0006350; P = 4.1 × 10-5) | |
| Cellular Component | Nucleus (GO:0005634; P = 2.0 × 10-25) |
| Replication fork (GO:0005657; P = 5.0 × 10-6) | |
| Transcription factor complex (GO:0005667; P = 2.8 × 10-4) | |
| Overexpressed Genes | |
| Metabolic and Regulatory Pathway | Oxidative phosphorylation (dme00190; P = 1.6 × 10-7) |
| Fatty acid metabolism (dme00071; P = 4.6 × 10-6) | |
| Glycolysis/Gluconeogenesis (dme00010; P = 6.3 × 10-6) | |
| Molecular Function | Oxireductase activity (GO:0016491; P = 2.8 × 10-10) |
| Serine-type peptidase activity (GO:0008236; P = 1.3 × 10-7) | |
| Hydrolase activity (GO:0016787; P = 2.8 × 10-2) | |
| Biological Process | Ion transporter (GO:0006811; P = 4.5 × 10-4) |
| Defense response (GO:0006952; P = 5.8 × 10-3) | |
| Pathways of carbohydrate metabolism (GO:0006092; P = 7.7 × 10-3) | |
| Cellular Component | Membrane (GO:0016020; P = 8.2 × 10-12) |
| Microsome (GO:0005792; P = 3.2 × 10-6) | |
| Mitochondrial electron transport chain (GO:0005746; P = 4.7 × 10-3) |
a GMRC, Gene Merge Class (see Methods).
b After Bonferroni correction.