Immunogenicity of P. falciparum (Pf) Circumsporozoite Protein (PfCSP) and P. yoelii (Py) CSP DNA Constructs in VR1020 and VR1020-DV
Dose 2 | Dose 3 | |
|---|---|---|
| PfCSP-VR1020 | 40 (0-160)a | 2560 (0-120)a |
| PfCSP-VR1020-DV | 40 (0-160)a | 1280 (0-2560)a |
| PyCSP-VR1020 | 2560 (0-10,240)b | 5120 (0-20,480)b |
| PyCSP-VR1020-DV | 1280 (0-5120)b | 2560 (0-5120)b |
| VR1020 | 0ab | 0ab |
Groups of 10 CD-1 mice were immunized ID with 100 μg of each DNA construct. Sera were collected 2 wks after doses 2 and 3.
a Sera tested by IFAT on air-dried P. falciparum sporozoites.
b Sera tested by IFA on air-dried P. yoelli sporozoites.