Comparison of the Fine Mapping of a Founder Mutation Using Case Haplotypes, Case Genotypes With Strategy A, and That With Strategy B for 100 Simulated Complex Disease Data Sets
Strategy | #Successesa | Mean(pos) | Std(pos) | Mean 95% PI width | RMSE | Size of cluster 1c |
|---|---|---|---|---|---|---|
| Phase known | 42 | 0.8852 | 0.0940 | 0.3389 | 0.0930 | 19.85 |
| A | 33 | 0.8489 | 0.0818 | 0.3299 | 0.0863 | 20.33 |
| Bb | 41 | 0.9081 | 0.0926 | 0.3401 | 0.0957 | 20.41 |
a The number of times that the method is successful, i.e., the 95% PI covers the true location and also has a width no greater than 25% of the whole region (1.73 cM).
b Phased by HAPLOTYPER.
c Average number of haplotypes being sorted into cluster 1. The total number of disease haplotypes is 50, of which 15 are the mutation-carrying haplotypes.