Family Classification of GPCRs
Number of genes | Number of known genes (against MGI) | Number of new genes (against MGI)a | Number of novel GPCRsb | Number of orphan GPCRs | |
|---|---|---|---|---|---|
| Family A (rhodopsin-like) | 165 | 134 | 31 | 8 | 45 |
| Family B (secretin-like) | 24 | 16 | 8 | 13 | |
| Family C (metabotropic glutamate/pheromone) | 11 | 4 | 7 | 4 | 4 |
| Family D (fungal pheromone-STE2/MAM2) | |||||
| Family E (fungal pheromone-STE3/MAP3) | |||||
| Family F (slime mold cAMP receptors) | 1 | 1 | 1 | 1 | |
| Frizzled/smoothened family | 8 | 8 | |||
| Vomeronasal receptor (V1R & V3R) | 1 | 1 | 1 | 1 | |
| Ocular albinism proteins | 1 | 1 | 1 | ||
| Others | 2 | 2 | 2 | ||
|
Total |
213 |
165 |
48 |
14 |
67 |
a These were not in the MGI database as of May 5, 2002, and therefore were hypothesized as representing homologs or paralogs to known genes
b Among the genes that were new to MGI (a), these had neither homologs nor paralogs registered in GenBank as of May 5, 2002 and were judged as novel genes