Table 3.

Top Thirty Gene Ontologies Associated With the Cell-Cycle Genes Identified in Figure 2A

Interpro ID
Molecular function
Count
Interpro ID
Biological process
Count
Interpro ID
Cellular omponent
Count
GO:0005524 ATP binding 401 GO:0006468 protein amino acid phosphorylation 170 GO:0005634 nucleus 422
GO:0003677 DNA binding 256 GO:0006355 regulation of transcription, DNA-dependent 164 GO:0005622 intracellular 133
GO:0016740 transferase 192 GO:0000074 regulation of cell cycle 129 GO:0016021 integral membrane protein 104
GO:0004672 protein kinase 169 GO:0007049 cell cycle 111 GO:0005615 extracellular space 80
GO:0004674 protein serine/threonine kinase 169 GO:0008151 cell growth and/or maintenance 95 GO:0016020 membrane 75
GO:0004713 protein tyrosine kinase 158 GO:0016288 cytokinesis 66 GO:0005737 cytoplasm 40
GO:0003700 transcription factor 88 GO:0006281 DNA repair 64 GO:0005856 cytoskeleton 35
GO:0016787 hydrolase 84 GO:0006260 DNA replication 60 GO:0005875 microtubule associated protein 30
GO:0016301 kinase 83 GO:0007242 intracellular signaling cascade 59 GO:0005667 transcription factor complex 29
GO:0003676 nucleic acid binding 72 GO:0007165 signal transduction 45 GO:0005694 chromosome 21
GO:0005515 protein binding 51 GO:0006810 transport 41 GO:0005739 mitochondrion 18
GO:0005525 GTP binding 50 GO:0007017 microtubule-based process 41 GO:0005886 plasma membrane 18
GO:0005509 calcium ion binding 48 GO:0007264 small GTPase mediated signal transduction 36 GO:0005871 kinesin 17
GO:0003774 motor 41 GO:0007067 mitosis 35 GO:0005783 endoplasmic reticulum 16
GO:0004872 receptor 41 GO:0006508 proteolysis and peptidolysis 33 GO:0005840 ribosome 16
GO:0000166 nucleotide binding 40 GO:0006412 protein biosynthesis 31 GO:0005718 nucleosome 15
GO:0003723 RNA binding 39 GO:0006470 protein amino acid dephosphorylation 27 GO:0005882 intermediate filament 14
GO:0003685 DNA repair protein 33 GO:0016538 cyclin-dependent protein kinase, regulator 26 GO:0005887 integral plasma membrane protein 14
GO:0003924 GTPase 33 GO:0007275 development 24 GO:0005717 chromatin 12
GO:0004386 helicase 29 GO:0007001 chromosome organization and biogenesis (sensu Eukarya) 23 GO:0005794 Golgi apparatus 12
GO:0003925 small monomeric GTPase 28 GO:0008283 cell proliferation 23 GO:0016459 myosin 12
GO:0003779 actin binding 26 GO:0006886 intracellular protein transport 22 GO:0005576 extracellular 11
GO:0008026 ATP dependent helicase 26 GO:0015031 protein transport 22 GO:0005813 centrosome 9
GO:0005198 structural molecule 25 GO:0006464 protein modification 21 GO:0005891 voltage-gated calcium channel complex 9
GO:0003754 chaperone 23 GO:0008152 metabolism 20 GO:0008287 protein serine/threonine phosphatase complex 9
GO:0000158 protein phosphatase type 2A 20 GO:0006118 electron transport 19 GO:0005663 DNA replication factor C complex 8
GO:0000163 protein phosphatase type 1 20 GO:0006334 nucleosome assembly 18 GO:0005681 spliceosome complex 8
GO:0003777 microtubule motor 20 GO:0006511 ubiquitin-dependent protein catabolism 18 GO:0030286 dynein 8
GO:0003824 enzyme 20 GO:0006915 apoptosis 18 GO:0005578 extracellular matrix 7
GO:0004722
protein serine/threonine phosphatase
20
GO:0007050
cell cycle arrest
18
GO:0005624
membrane fraction
7

[i] Gene Ontology assignments from MGI for the RPS sequences were extracted and ranked. Assignments made by SCOP to GO mappings were ignored for this table