Table 10.

Uncharacterized Genes With Classifications That Match Biological Functions Deduced From Homology Information

Symbol (GenBank accession number) Gene name Homology information Classification Classification matching assumed biological process (PMID reference)
LOC55977  (AA037007)Hypothetical protein 24636 Homo sapiens thromboxane A-2 receptor, 53%/55 aaProtein metabolism and modification, lipid metabolism, developmental processes, blood coagulationDevelopmental processes (10963722) blood coagulation (8777579)
FLJ10217  (W721889)Oxysterol-binding protein-related protein 1 H. sapiensoxysterol-binding protein, 36%/711 aaCell death, blood coagulationCell death (10617772) blood coagulation (10617772)
WW45 (H25014)WW domain-containing geneWW domainCell surface receptor-linked signal transduction, transcriptionTranscription (11223034)
PIST(N68337)PDZ/coiled-coil domain-binding partner for the rho-family GTPase TC10 Mus musculus syntrophin, 43%/110 aaStress response, protein metabolism and modification, cell surface receptor-linked signal transduction, transcriptionStress response (10212242, 10797403)
ESTs (N33510)ESTs, weakly similar to a chain A, human Cd69–trigonal form (SUB 82-199 (H. sapiens) H. sapiens cd69, 52%/37 aaCell surface receptor-linked signal transduction, cell cycle, transcriptionCell surface receptor-linked signal transduction (11092246)
PTGFRN  (AA045111)Prostaglandin F2 receptor negative regulatorOrtholog of Ratius norvegicusprostaglandin F2 receptor negative regulator (http://www.ncbi.nlm.nih.gov/HomoloGene/homol.cgi)Transcription, oncogenesisOncogenesis (11090944)
H-I(3)mbt-I  (AA026761)H-I(3)mbt-like protein Drosophila melanogaster T13797 tumor suppressor protein, 46%/176 aaCell proliferation, lipid metabolism, transcription, oncogenesisCell proliferation, oncogenesis (10445843)
LOC57018  (AA016305)Cyclin L ania-6a H. sapiens cyclin K, 27%/363 aaCell proliferation, transcription, oncogenesisCell proliferation, transcription (9632813)
HMGE  (AA037156)GrpE-like protein cochaperone Escherichia coli heat shock protein grpE, 32%/178 aaStress response, protein metabolism and modificationStress response, protein metabolism and modification (10791710)
G2 (R16047)G2 protein H. sapiensG01449 probable mucin, 100%/1691 aaCell adhesion, cell cycle, DNA metabolism, protein targetingCell adhesion (1412714)
(H72723)ESTs, highly similar to SMHU1B metallothionein 1B (H. sapiens) H. sapiens SMHU1B metallothionein 1B, 98%/60 aaStress response, protein metabolism and modification, ion homeostasisStress response, ion homeostasis (10801901)

[i] This table shows the 11 out of 24 uncharacterized genes for which homology information could be found that allowed assumptions concerning functional classification of the gene, and one or more of the homology-based annotations matched the predicted (classified) biological process function.