Table 1.

SNPs Identified From the C11orf24–LRP5–C22orf23Region, Showing the Method of Identification, Method of Genotyping, and Allele Frequency in 192 UK Individuals

SNP name Method of identification[i] dbSNP ss # Typing method[v] Frequency
C11orf24 c.598G→A 6905350Invader/RFLP(PstI)0.49
EO864-6688 6905352RFLP/DraI0.49
EO864-4419G→A 6905353RFLP/NcoI0.29
LRP5 g.-14447C→A 62019-20t1_L1TT 6905427RFLP/DpnII0.009
LRP5 g.-14279A→G 6905354Invader/cRFLP(NruI)0.34
LRP5 g.-13901G→A 62019-20t1_L1TT 6905428RFLP/HaeIII0.06
LRP5 g.-13340-13366del-ins 62019-20t1_L1TT 6905429Length polymorphism0.13
LRP5 g.-11215T→A 6905355NT
LRP5 g.-11094G→A 6905356NT
LRP5 g.-10088G→A 6905357Invader/RFLP(FauI)0.27
LRP5 g.-9693G→A 6905358Invader0.27
LRP5 g.-9003T→C 6905359NT
LRP5 g.-8870G→A 6905360NT
LRP5 g.-5977C→T 6905361NT
LRP5 g.-5880T→C 6905362NT
LRP5 g.-5802G→C 6905363Invader/RFLP(HincII)0.27
LRP5 g.-5677C→T 6905364Invader/RFLP(MspI)0.27
LRP5 g.-5264G→A 6905365Invader/RFLP(AflIII)0.27
LRP5 g.-4317G→A 62019-20t1_L1TT 6905430Invader0.20
LRP5 g.-2945C→T 62019-20t1_L1TT 6905431Invader0.20
LRP5 g.-2713C→A 62019-20t1_L1TT 6905432Invader0.10
LRP5 g.-2517A→G 62019-20t1_L1TT 6905433Invader0.06
LRP5 g.-2366C→G 62019-20t1_L1TT 6905434Invader0.08
LRP5 g.-1792T→G 62019-20t1_L1TT 6905435Invader0.10
LRP5 g.-864A→G 6905366Invader/RFLP(MspI)0.27
LRP5 g.817C→T 62019-20t1_L1TT 6905436Invader0.064
LRP5 g.2221C→T 6905367Invader/cRFLP(Hph)0.27
LRP5 g.3103C→G 6905368Invader/RFLP(pflMI)0.27
LRP5 g.4780G→C 6905369Invader/RFLP(EcoNI)0.34
LRP5 g.5151C→T 62019-20t1_L1TT 6905437Invader0.075
LRP5 g.5257T→G 6905370Invader/cRFLP(SnaBI)0.28
LRP5 g.6088T→C 6905371NT
LRP5 g.7374G→A 6905372Invader/RFLP(AvaI)0.35
LRP5 g.8003A→G 6905373NT
LRP5 g.8651T→G 6905374NT
LRP5 g.8924T→C 6905375NT
LRP5 g.10133insT 6905376NT
LRP5 g.10655A→T 6905377NT
LRP5 g.10674C→T 6905378NT
LRP5 g.11084T→C 6905379NT
LRP5 g.11263A→G 6905380NT
LRP5 g.11386A→G 6905381NT
LRP5 g.11886A→G 6905382NT
LRP5 g.13279C→T 6905383Invader/PvuII0.35
LRP5 g.13963C→T 6905384Invader0.006
LRP5 g.14250G→A 6905385NT
LRP5 g.14560C→T 6905386NT
LRP5 g.15531delG 6905387NT
LRP5 g.16868G→A 6905388NT
LRP5 g.17646G→T 6905389Invader/BgIII0.42
LRP5 g.23715C→A 6905390NT
LRP5 g.24964C→T 6905391Invader/RFLP(MnII)0.14
LRP5 g.26659A→G 6905392NT
LRP5 g.27081G→C 6905393NT
LRP5 g.28047T→C 6905394NT
LRP5 g.28149C→T 6905395Invader/RFLP(MboII)0.42
LRP5 g.29652T→C 6905396NT
LRP5 g.29925T→C 6905397NT
LRP5 g.31502G→A 6905398NT
LRP5 g.31856G→A 6905399Invader/RFLP(DpnI)0.094
LRP5 g.34749G→A 6905400NT
LRP5 g.35592T→C 6905401Invader0.44
LRP5 g.37442A→C 6905402NT
LRP5 g.37679G→A 6905403NT
LRP5 g.38270G→A 6905404NT
LRP5 g.38393C→T 6905405NT
LRP5 g.38590C→T 6905406NT
LRP5 g.38885C→A 6905407NT
LRP5 g.39440A→G 6905408NT
LRP5 g.39807T→G 6905409NT
LRP5 g.40495C→G 6905410NT
LRP5 g.42125G→T 6905411Invader0.44
LRP5 g.43231G→A 6905412NT
LRP5 g.43404A→G 6905413NT
LRP5 g.43718G→A 6905414NT
LRP5 g.44602insC 6905415NT
LRP5 g.45704G→A 6905416Invader0.44
LRP5 g.47698G→A 6905417NT
LRP5 g.75326G→A 6905418RFLP/HphI0.19
LRP5 g.78477G→A 6905419NT
LRP5 g.92423G→A 62019-20t1_L1TT 6905438RFLP/Tsp4510.017
LRP5 g.95318G→A 6905420NT
LRP5 g.95385G→A 6905421RFLP/HaeIII0.05
LRP5.30g.5276C→TASN740 6905422ARMS0.16
LRP5 30g.5380C→T 6905425ARMS0.07
LRP5 30g.6891C→T 6905426ARMS0.07
LRP5 30g.19977T→G 6905423NT
LRP5 30g.20149A→G 6905424NT
LRP5 30g.24930C→T 62019-20t1_L1TT 6905439cRFLP/NdeI0.31
LRP5 30g.29264C→T 6905351RFLP/AciI0.16
LRP5 30g.34160G→C 62019-20t1_L1TT 6905440RFLP/RsaI0.08
LRP5 30g.34295T→C 62019-20t1_L1TT 6905441cRFLP/MspA110.006
C11orf23 c.3297-3302del 6905347Invader/length polymorphism0.25
C11orf23 c.3488G→A 6905348Invader/cRFLP(NlaIII)0.32
C11orf23 c.3680G→A 6905349Invader/0.24

[i] ○ = Identified initially from cosmid/BAC overlaps.

[ii] ♦ = Identified initially from shotgun sequencing of 5-kb-long PCR products.

[iii] ■ = Identified initially by directed PCR amplification and sequencing of the LRP5 gene.

[iv] [Private character 62019-20t1_L1TT] = Identified from dHPLC.

[v] NT = not tested.