Table 5.

Rules for Multiple Regulated Systems

Regulator1
Regulator2
Conformation of regulator1
Conformation of regulator2
Predicted discrete state
Experimental discrete state
Consistency
Any two activators
activator activator activating activating on on direct
activator activator not activating not activating off on incongruent
activator activator not activating activating on on activator rule
activator activator not activating activating on off incongruent
activator activator not activating not activating off off direct
One activator is CRP
Crp activator not activating activating off off crp rule
Crp activator not activating activating off on incongruent
Crp activator activating activating on on direct
Crp activator not activating not activating off on incongruent
Repressors
repressor repressor repressing not repressing off on incongruent
repressor repressor repressing repressing off off direct
repressor repressor not repressing repressing off off repressor rule
Dual groups
activator repressor activating repressing off on incongruent
activator repressor activating not repressing on on direct
activator repressor not activating not repressing ??? on basal level
activator repressor activating repressing off off repressor rule
activator
repressor
not activating
repressing
off
off
direct

[i] Example of multiple interaction rules extracted from literature for positive, negative, and dual regulated. The first two columns describe the regulator function. Columns 3 and 4 represent the state of the regulator. Column 5 describes the predicted state. Column 6 gives the microarray discrete state, and column 7 represents the consistency between columns 5 (predicted discrete state) and 6 (experimental discrete state).