Recombinant Genotypes Specify the Boundaries of the lypCritical Interval in the Rat
| Cross | Rat | 5631CA3c | UW33 | H16 | K43 | H4 | lyp | llsnp3 | Clast1 | K11a11 | 28e5e09 | ||||
| BB-DP × BB-DR | 11CF2 19:2 | 3 | 3 | 3 | 3 | 3 | + | nt | 3 | 3 | X | 1 | |||
| 2CF3 1:12 | 1 | 1 | nt | nt | 1 | Lp | nt | X | nt | nt | 3 | ||||
| BB-DP × F344 | 1FBF2 18:6 | 1 | 1 | 1 | 1 | 1 | Lp | 111 × 33 | 3 | 3 | 3 | ||||
| 2FBF2 11:5 | 1 | 1 | 1 | 1 | 1 | Lp | 11111 | X | 3 | 3 | 3 | ||||
| 4FBF2 14:13 | 3 | 3 | 3 | 3 | 3 | + | 33333 | 3 | X | 1 | 1 | ||||
| 4FBF2 31:11 | 3 | 3 | X | 1 | 1 | 1 | Lp | 11111 | 1 | nt | 1 |
[i] The type of cross and the identification of the recombinant animals are listed to the left and the genotypes (or phenotypes in the case of lyp) at selected loci are shown. The key recombinant animals defining the lyp critical interval H16-1Isnp3 are 4FBF2 31:11 on the left (proximal) side and 1FBF2 18:6 on the right (distal) side. The X marks indicate the inferred locations of recombination breakpoints, nt indicates genotypes not tested. Lp is lymphopenic (the cut off value is 15%, representing the mean + 14SD) and + indicates a normal (non-lyp) phenotype. SNP marker IIsnp3 is not polymorphic in the BBDP × BBDR cross.