Comparison of Domain Architectures in the 271 Groups of Common Enzymes
| Type of group | Number of groups | Totals |
| Identical domain architecture and number of chains | 80 | Groups that have same or very similar |
| Different domain architecture, same number of chains, potentially same | 16 | domain architecture: 179 |
| Same domains in a different order | 4 | |
| Same domain architecture, yeast has more chains with this domain architecture (likely larger number of isozymes) | 26 | |
| Same domain architecture,E. coli has more chains with this domain architecture (likely larger number of isozymes) | 14 | |
| Same domain, but either the yeast or E. coli chain has two copies of the domain (internal duplication) | 2 | |
| Same domains, cases of gene fusion (These correspond to the cases listed in Table 7; several common enzyme groups can correspond to one fusion case.) | 37 | |
| E coli has extra domains and/or chains | 26 | Groups that have shared domains and |
| Yeast has extra domains and/or chains | 21 | varied domains: 56 |
| Both organisms have extra domains and/or chains | 9 | |
| No domains shared (non-orthologous displacement) | 13 | Groups that do not share domains: 13 |
| Potential cases of non-orthologous displacement (incomplete assignments) | 6 | Groups that cannot be classified: 23 |
| Neither E. coli nor yeast chains have any assignment | 2 | |
| Either yeast or E. coli chains have no assignment | 15 |