Table 3.

Global Changes of Gene Expression Induced by Thyroid Hormone in Human Vastus Lateralis Skeletal Muscle

Functional classes Number (%)
Transcriptional control33 (8.7)
 Transcription factors
 Coactivators/corepressors
 Histone (de)acetylation
Protein synthesis14 (3.7)
 Ribosomal proteins
 Translation initiation factors
Glucose and lipid metabolism8 (2.1)
 Glycogen synthesis and glucose utilization
Signal transduction36 (9.4)
 Protein phosphatases
 Protein kinases
 G proteins
 G protein–coupled receptors
Cytoskeleton21 (5.5)
Ribonucleoproteins and RNA metabolism16 (4.2)
 Pre-mRNA processing
Protein catabolism20 (5.2)
 Ubiquitin-proteasome pathway
Mitochondrial energy metabolism22 (5.8)
 Respiratory chain proteins
 Mitochondrial carriers
 Citric acid cycle
Cellular trafficking13 (3.4)
 Intracellular transport
Cellular immunity9 (2.4)
Miscellaneous45 (12)
Expressed sequence tags144 (38)