Two-dimensional clustering of 19 tissue experiments and 403 transcripts, which showed variation after triiodothyronine treatment. The set of genes were selected from the data matrix provided by the hybridization of 19 human tissues and cell lines to a common reference pool. Experiments and responsive genes were grouped by hierarchical clustering after centering the log2 ratios on the mean for all experiments. Each row represents a single gene and each column an experimental sample. For each sample, the ratio of the abundance of the transcripts of each gene to the mean abundance across all experiments is represented by the color of the corresponding cell in the matrix file. (green boxes) Transcript levels lower than the mean. (red boxes) Transcript levels higher than the mean. (black boxes) transcript level equal to the mean. (gray lines) missing data. Each node of the gene dendrogram was analyzed, and we focused on sets of genes clustered by functions. The upper dendrogram shows similarities in the expression pattern between tissues and cell lines. (A) Protein turnover cluster. (B) Energy metabolism cluster.
