Reaction participation values for all of the data sets calculated in this study. (A,B) The spectrum of reaction participation values, with a shortened x-axis so as to highlight the non-zero reaction participation values. Note the three regions inA and B as follows: (1) set of reactions that participate in all of the extreme pathways; (2) reactions that participate in varying amounts of extreme pathways; and (3) reactions that do not participate in any of the extreme pathways. Also note that the ordering of the reaction number is different for each data set so that the reaction number in each set corresponds to a different reaction.