Imprinting regulation of Kip2/Lit1 subdomain by DMR-Lit1. Expression and DNA methylation status of imprinting cluster in this domain are depicted. The hypothetical mechanism of DMR-Lit-1 is described in the Discussion. Bent arrows indicate a parental-dependent transcription. Horizontal arrows pointing toward left show hypothetical enhancers that were suggested to exist experimentally (Cleary et al. 2001; John et al. 2001). Lollipops represent CGIs 1 to 10. Closed lollipops: methylated DNA; open lollipops: nonmethylated DNA. M, maternal allele; P, paternal allele. HSS-1, HSS-2, and HSS-3 show nuclease-hypersensitive sites near CGI8, CGI4, and CGI5, respectively. Not drawn to scale.