Mutant Frequencies and Genome Rearrangements in Organs of Young and Old Mice
| Organ | Age (mo) | LacZ mutant frequency (×10−5)[i] | Genome rearrangements per cell[ii] | P [iii] | |||||
| total | genome rearrangements | ||||||||
| Brain | 4 | 3.1 ± 0.3 | 0.5 ± 0.1 | 5 | 0.7333 | ||||
| 32 | 5.0 ± 1.3 | 0.6 ± 0.4 | 6 | ||||||
| Liver | 4 | 3.1 ± 0.3 | 0.9 ± 0.2 | 9 | 0.0140 | ||||
| 32 | 10.5 ± 2.4 | 2.7 ± 1.0 | 27 | ||||||
| Heart | 3 | 4.1 ± 1.4 | 1.9 ± 0.8 | 19 | 0.0262 | ||||
| 32 | 10.1 ± 2.7 | 3.7 ± 2.0 | 37 | ||||||
| Small intestine | 3 | 6.1 ± 1.8 | 1.5 ± 0.5 | 15 | 0.9999 | ||||
| 32 | 19.5 ± 1.0 | 2.4 ± 2.1 | 24 | ||||||
[i] Mean ± SD.
[ii] Average number of genome rearrangements per diploid genome, based on a 3-kb target locus, a 6 × 106 kb diploid genome, and a twofold chance of a breakpoint falling within a reporter gene.
[iii] Significance between age groups within organs for genome rearrangements using the Wilcoxon rank sum test.