SCOP Superfamilies Associated With Transmembrane Proteins
| SCOP Superfamily | Human | Fly | Worm | Yeast | ||||||||
| N | % | R | N | % | R | N | % | R | N | % | R | |
| Immunoglobulin | 463 | 38 | 1 | 126 | 26 | 4 | 74 | 16 | 5 | – | – | – |
| Cadherin | 440 | 72 | 2 | 206 | 93 | 1 | 114 | 84 | 2 | – | – | – |
| Fibronectin type III | 359 | 43 | 3 | 134 | 54 | 3 | 66 | 30 | 7 | – | – | – |
| EGF/laminin | 216 | 18 | 4 | 139 | 43 | 2 | 163 | 39 | 1 | – | – | – |
| Ligand-binding domain of low-density lipoprotein receptor | 126 | 51 | 5 | 106 | 54 | 5 | 79 | 55 | 4 | – | – | – |
| P-loop containing nucleotide triphosphate hydrolases | 87 | 10 | 6 | 89 | 15 | 6 | 91 | 18 | 3 | 41 | 10 | 1 |
| Protein kinase-like (PK-like) | 65 | 12 | 7 | 27 | 10 | 12 | 72 | 17 | 6 | – | – | – |
| Complement control module/SCR domain | 56 | 20 | 8 | 25 | 44 | 13 | 3 | 6 | 65 | – | – | – |
| C-type lectin-like | 53 | 36 | 9 | 3 | 8 | 54 | 34 | 11 | 8 | – | – | – |
| MHC antigen-recognition domain | 47 | 82 | 10 | – | – | – | – | – | – | – | – | – |
| TNF receptor-like | 38 | 73 | 11 | 2 | 100 | 67 | – | – | – | – | – | – |
| RNI-like | 34 | 35 | 12 | 31 | 35 | 8 | 14 | 38 | 23 | – | – | – |
| Serine protease inhibitors | 32 | 25 | 13 | 17 | 41 | 19 | 18 | 21 | 19 | – | – | – |
| Periplasmic binding protein-like I | 28 | 93 | 14 | 16 | 73 | 22 | 30 | 88 | 11 | – | – | – |
| ConA-like lectins/glucanases | 27 | 20 | 15 | 28 | 42 | 10 | 27 | 26 | 12 | 5 | 63 | 10 |
| RING-finger domain, C3HC4 | 25 | 12 | 16 | 17 | 16 | 19 | 20 | 16 | 18 | 5 | 15 | 10 |
| L domain-like | 25 | 21 | 16 | 25 | 26 | 13 | 23 | 16 | 15 | 1 | 8 | 38 |
| Spermadhesin, CUB domain | 24 | 19 | 18 | 42 | 50 | 7 | 23 | 13 | 15 | – | – | – |
| (Phosphotyrosine protein) phosphatases II | 23 | 21 | 19 | 7 | 17 | 30 | 14 | 14 | 23 | – | – | – |
| EF-hand | 23 | 8 | 19 | 15 | 9 | 24 | 10 | 8 | 29 | – | – | – |
| Metalloproteases (“zincins”), catalytic domain | 22 | 33 | 21 | 4 | 15 | 43 | 8 | 16 | 37 | – | – | – |
| POZ domain | 22 | 18 | 21 | 5 | 5 | 37 | 22 | 15 | 17 | – | – | – |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 21 | 11 | 23 | 17 | 25 | 19 | 32 | 36 | 10 | 16 | 50 | 2 |
| Ankyrin repeat | 21 | 8 | 23 | 18 | 15 | 18 | 34 | 27 | 8 | 5 | 16 | 10 |
| Extracytoplasmic domain of cation-dependent mannose 6-phosphate receptor | 15 | 88 | 32 | – | – | – | – | – | – | 1 | 100 | 38 |
| SpoIIaa | 5 | 83 | 63 | 4 | 100 | 43 | 5 | 100 | 53 | 2 | 100 | 25 |
| Adenylyl and guanylyl cyclase catalytic domain | 16 | 67 | 29 | 28 | 76 | 10 | 26 | 70 | 13 | – | – | – |
| Blood coagulation inhibitor (disintegrin) | 18 | 67 | 26 | 3 | 43 | 54 | 4 | 67 | 58 | – | – | – |
| Periplasmic binding protein-like II | 16 | 62 | 29 | 30 | 77 | 9 | 12 | 92 | 25 | – | – | – |
| Syntaxin 1A N-terminal domain | 8 | 62 | 47 | 5 | 56 | 37 | 8 | 62 | 37 | 7 | 88 | 5 |
| L-2-Haloacid dehalogenase | 11 | 61 | 34 | 2 | 10 | 67 | 5 | 28 | 53 | 2 | 13 | 25 |
| Snake toxin-like | 5 | 56 | 63 | 2 | 100 | 67 | 1 | 50 | 98 | – | – | – |
| Metal-binding domain | 6 | 55 | 58 | 4 | 80 | 43 | 4 | 80 | 58 | 5 | 71 | 10 |
| Transferrin receptor ectodomain, apical domain | 7 | 54 | 53 | – | – | – | 2 | 50 | 79 | 3 | 75 | 20 |
[i] The table gives the number (N) of domains in each superfamily that are found in sequences that have a transmembrane section. The “%” is percentage of the toal occurrence of each domain in the proteome (i.e., transmembrane and nontransmembrane chains, see Table 1). R denotes the rank of N. The lower part of the table details superfamilies with highest percentages in membrane proteins and with a frequency of at least five domains in human that are not reported in the upper part.