Markup | Genome Research

Table 1.

N2 Offspring from Crosses of C57BL/6J and DBA/2J Mice to D2B6F1Apc^Min /+ Mice Reveal Germline Transmission of a New Modifier of M in2(Mom2) Locus

D2B6F1 Apc ^Min parent[i]		Sex of F1 parent		# Polyps in F1 parent[ii]		Age (days)[iii]		D2B6F1Apc ^Min × C57BL/6J[i]		D2B6F1 Apc ^Min × DBA/2J[i]
D2B6F1 Apc ^Min parent[i]		Sex of F1 parent		# Polyps in F1 parent[ii]		Age (days)[iii]		High[iv]	Low[iv]	High[iv]	Low[iv]
1	male	39	351	6 (70.2 ± 25.5)	0	9 (58.1 ± 16.4)	1 (10)
2	male	37	331	6 (98.0 ± 24.9)	0	9 (53.1 ± 22.4)	0
3	male	61	351	5 (52.8 ± 14.7)	0	—	—
4	female	100	315	—	—	9 (49.4 ± 19.4)	1 (17)
Total mice				17	0	27	2
5[v]	male	6	472	2 (91.0 ± 48.1)	17 (5.0 ± 3.3)	4 (63.8 ± 18.2)	8 (8.8 ± 6.9)
6[v]	male	7	405	3 (70.7 ± 34.0)	9 (4.6 ± 4.8)	1 (76)	8 (7.3 ± 5.2)
7[v]	female	52	658	10 (100.5 ± 57.3)	38 (6.3 ± 5.3)	—	—
Total mice				15	64	5	16

[i] Seven D2B6F1 Apc^Min mice were crossed to C57BL/6J and/or DBA/2J mice as indicated in the last two column headings. The number of N2 offspring in the high and low polyp class is shown. N2 offspring were counted at 4–5 mo of age, with the exception of four mice from each backcross that were counted at >1 y of age. Average polyp numbers of resulting N2 offspring are shown ± standard deviation in parentheses.

[ii] The number of polyps present in the small intestine of each D2B6F1 Apc^Min /+ parent.

[iii] The age in days of the D2B6F1Apc^Min /+ parent at the time polyps were counted.

[iv] Based on the distribution of polyps in the F1 animals (Fig. 1B), those animals with ≤24 polyps constitute the “low” polyp group and those animals with ≥25 polyps constitute the “high” polyp group.

[v] Parents #5, #6, and #7 produced sufficient numbers of offspring with low polyp multiplicity and were therefore classified as the only D2B6F1 Apc^Min parents that both carried and transmitted the resistant Mom2^R allele.