Table 5.

Classification of Gene Groups Associated with Liver Development

Primary acc. L1 L2 L3 L4 IC HC Gene definition Gene cat.
Gene Group I: Genes ubiquitously expressed in liver
V009454694453517serum albumin (ALB)IX
M11147 4912235ferritin L chainI
X01683 1362967alpha 1-antitrypsinXI
X00955 1125793apolipoprotein AIIIX
X16064 11152299translationally controlled tumor proteinVI
X02761 367310fibronectinXIII
L22154 25495ribosomal protein L37aVII
X89401 33336ribosomal protein L21VII
U14968 432296ribosomal protein L27aVII
Gene Group II: Genes expressed only in HFL19w and HFL22w, but not in HFL40w nor HAL
D14531 51385homolog of rat ribsomal protein L9VII
V01514 3122alpha-fetoprotein (AFP)IX
X56932 211923 kD highly basic proteinXII
U14966 293ribosomal protein L5VII
D14530 2636homolog of yeast ribosomal protein S28VII
S56985 2653ribosomal protein L19VII
X69150 252fibosomal protein S18VII
M77234 253ribosomal protein S3aVII
M17733 359thymosin beta-4III
J02984 22insulinoma rig-analog mRNA encoding  DNA-binding proteinVI
X69391 3222ribosomal protein L6VII
Gene Group III: Genes expressed only in HAL and HFL40w, but not in HFL19w nor HFL22w
M13692 415alpha-1 acid glycoproteinXII
X05151 37apoC-II preproapolipoprotein C-IIIX
M20496 324cathepsin LXI
D00097 42serum amyloid P component (SAP)X
Gene Group IV: Genes expressed only in HFL19w, 22w, 40w and HAL, but not in HepG2 cell
S95936 346610transferrinXII
J00129 2141158fibrinogen beta chainIX
X51473 73825fibrinogen gamma chainIX
M11313 61835alpha 2-macroglobulinIV
M64982 616152fibrinogen alpha chainIX
X02747 31025aldolase BX
X02761 367310fibronectinXIII
M10050 9668liver fatty acid binding protein (FABP)IX
X00637 2341528haptoglobin alpha 1S (Hpa 1S)IX

[i] L1, human fetal liver aged 19 wk of gestation; L2, human fetal liver aged 22 wk of gestation; L3, human fetal liver aged 40 wk of gestation; L4, adult liver; IC, Itoh cell; HC: HepG2 cell.