Shared Characteristics between Sequence-Related Enzymes
| Enzymes | PAM | Mechanism[i] | Substrate | Cofactor | Pathway | Sequential[ii] |
| EntE–EntF | 185 | + | + | − | + | − |
| PurK–PurT | 174 | + | + | − | + | − |
| GuaB–GauC | 116 | + | + | − | + | − |
| MurC–MurE | — | + | + | − | + | − |
| MurF–MurD | 196 | + | + | − | + | − |
| MurF–MurC | 193 | + | + | − | + | + |
| MurF–MurE | 185 | + | + | − | + | + |
| MurC–MurD | 173 | + | + | − | + | + |
| MurD–MurE | 158 | + | + | − | + | + |
| PurF–AsnB | — | + | + | − | − | − |
| AsnB–GlmS | 185 | + | + | − | − | − |
| GlmS–PurF | 155 | + | + | − | − | − |
| TrpE–PabB | 127 | + | + | − | − | − |
| Gcl–PoxB | 173 | + | − | + | − | − |
| PoxB–IlvI | 140 | + | − | + | − | − |
| IlvI–Gcl | 124 | + | − | + | − | − |
| MetB–MetC | 144 | + | − | + | + | + |
| MenF–PabB | 221 | − | + | − | − | − |
| MenF–TrpE | 185 | − | + | − | − | − |
| HisA–HisF | 180 | − | − | − | + | + |
[i] Chemistry mechanism of the reaction catalyzed.
[ii] Sequential: one product is substrate for the subsequent reaction (sequential enzymes in a pathway).
[iii] “+” indicates “same,” “similar” or “yes,” and “−” indicates “different” or “no”.
[iv] Sources: Gene and PAM value, GenProtEC; mechanism of action, BRENDA and EC nomenclature; substrate, cofactor, and pathway, EcoCyc.