Table 1.

List of Human ABC Genes, Chromosomal Location, and Function

Gene Alias Location Subfamily Expression Function
ABCA1 ABC1 9q31.1ABC1UbiquitousCholesterol efflux onto HDL
ABCA2 ABC2 9q34ABC1BrainDrug resistance
ABCA3 ABC3, ABCC 16p13.3ABC1Lung
ABCA4 ABCR 1p22.1-p21ABC1PhotoreceptorsN-retinylidene-PE efflux
ABCA5 17q24ABC1Muscle, heart, testes
ABCA6 17q24ABC1Liver
ABCA7 19p13.3ABC1Spleen, thymus
ABCA8 17q24ABC1Ovary
ABCA9 17q24ABC1Heart
ABCA10 17q24ABC1Muscle, heart
ABCA12 2q34ABC1Stomach
ABCA13 7p11-q11ABC1Low in all tissues
ABCB1 PGY1, MDR 7p21MDRAdrenal, kidney, brainMultidrug resistance
ABCB2 TAP1 6p21MDRAll cellsPeptide transport
ABCB3 TAP2 6p21MDRAll cellsPeptide transport
ABCB4 PGY3 7q21.1MDRLiverPC transport
ABCB5 7p14MDRUbiquitous
ABCB6 MTABC3 2q36MDRMitochondriaIron transport
ABCB7 ABC7 Xq12-q13MDRMitochondriaFe/S cluster transport
ABCB8 MABC1 7q36MDRMitochondria
ABCB9 12q24MDRHeart, brain
ABCB10 MTABC2 1q42MDRMitochondria
ABCB11 SPGP 2q24MDRLiverBile salt transport
ABCC1 MRP1 16p13.1CF/MRPLung, testes, PBMCDrug resistance
ABCC2 MRP2 10q24CF/MRPLiverOrganic anion efflux
ABCC3 MRP3 17q21.3CF/MRPLung, intestine, liverDrug resistance
ABCC4 MRP4 13q32CF/MRPProstateNucleoside transport
ABCC5 MRP5 3q27CF/MRPUbiquitousNucleoside transport
ABCC6 MRP6 16p13.1CF/MRPKidney, liver
CFTR ABCC7 7q31.2CF/MRPExocrine tissueChloride ion channel
ABCC8 SUR 11p15.1CF/MRPPancreasSulfonylurea receptor
ABCC9 SUR2 12p12.1CF/MRPHeart, muscle
ABCC10 MRP7 6p21CF/MRPLow in all tissues
ABCC11 MRP8 16q11-q12CF/MRPLow in all tissues
ABCC12 MRP9 16q11-q12CF/MRPLow in all tissues
ABCD1 ALD Xq28ALDPeroxisomesVLCFA transport regulation
ABCD2 ALDL1, ALDR 12q11-q12ALDPeroxisomes
ABCD3 PXMP1, PMP70 1p22-p21ALDPeroxisomes
ABCD4 PMP69, P70R 14q24.3ALDPeroxisomes
ABCE1 OABP, RNS41 4q31OABPOvary, testes, spleenOligoadenylate binding protein
ABCF1 ABC50 6p21.33GCN20Ubiquitous
ABCF2 7q36GCN20Ubiquitous
ABCF3 3q25GCN20Ubiquitous
ABCG1 ABC8, White 21q22.3WhiteUbiquitousCholesterol transport?
ABCG2 ABCP, MXR, BCRP 4q22WhitePlacenta, intestineToxin efflux, drug resistance
ABCG4 White2 11q23WhiteLiver
ABCG5 White3 2p21WhiteLiver, intestineSterol transport
ABCG8 2p21WhiteLiver, intestineSterol transport