This picture shows clonal heterogeneity that is derived from the same clone. (M) Marker lane that contains a mixture of two commercially available markers as described in Methods. The DNAs shown in lanes A and B were isolated from different single colonies that are derived from the same clone. (Arrows) InconsistentEcoRI fragments between the clones. Some of the marker sizes are indicated. The fingerprints show rearrangements that took place during cell duplication.