Table 5.

Examples of Superfamilies Present in Both Single- and Multi-Domain Proteins, Carrying out Different Functions

Table 5A. Single-Domain Proteins
Sfam Funct # SWISS-PROT ID SWISS-PROT function
352#FTN2_HAEINFerritin-like Protein 2
1.25.1183#NIGY_DESVHNigerythrin
E1.17.4RIR4_YEAST(Ribonucleotide Reductase) (1.17.4.1)
192#NLP_HAEINNer-like Protein Homolog
1.4.3196#H1A_PLADUHistone H1A, Sperm
1.81.2E2.5.1PFTB_PEAFarnesyltransferase Beta Su (2.5.1.–)
226#ERBP_RATEpididymal-Tetinoic Acid Binding Protein
227#FAB3_CAEELFatty Acid-Binding Protein Homolog 3
2.45.1228#412#NGAL_MOUSENeutrophil Gelatinase-Assoc. Lipocalin
229#NP4_RHOPRNitrophorin 4 Precursor
E5.3.99PGHD_HUMANProstaglandin-H2 D-Isomerase (5.3.99.2)
230#421#VNS1_MOUSEVesomeral Secretory Protein I
2.5.1231#MPA3_AMBELPollen Allergen AMB A 3 (AMB A Iii)
232#427#SOXE_SULACSulfocyanin (Blue Copper Protein)
3.14.2373#RRF1_DESVHRrf1 Protein
E6.3.4PURA_CAEELAdenylosuccinate Synthetase (6.3.4.4)
3.29.1E2.7.4KTHY_YEASTThymidylate Kinase (2.7.4.9)
D259#VA57_VACCVGuanylate Kinase Homolog
E2.7.1KITH_VZVWThymidine Kinase (2.7.1.21)
3.47.1275#MBL_BACSUMBL Protein
276#MREB_BACSURod Shape-determining Protein Mreb
3.48.1E3.1.3PPA5_YEASTRepressible Acid Phosphatase (3.1.3.2)
3.81.1D281#AMIC_PSEAEAliphatic Amidase Expression-Regulator
282#LUXP_VIBHALUXP Protein Precursor
4.103.1E2/4/2TOX1_BORPEPertussis Toxin Su 1 (2.4.2.–)
4.105.1291#LECC_POLMILectin–Polyandrocarpa Misakiensis
4.11.5295#TERP_PSESPTerpredoxin
4.19.1E5.2.1FKB1_METJAPept-ProlylCis-Trans Isomerase (5.2.1.8)
6.5.1E3.6.1ATPL_VIBALATP Synthase (3.6.1.34) (Lipid-binding)
540#325#BACT_HALVASensory Rhodopsin II (Sr-Ii)
7.35.4E1.9.3COXB_RATCytochrome C Oxidase (1.9.3.1) (Via*)
345#DESR_DESBIDesulforedoxin (Dx)
7.7.1349#TAP_ORNMOTick Anticoagulant Peptide
Table 5B. Multi-Domain Proteins
Sfam Comb. Funct# SWISS-PROT ID SWISS-PROT function
1.25.1/7.35.4104#RUBY_METJAPutative Rubrerythrin
11#PURR_HAEINPurine Nucleotide Synthesis Repressor
1.32.1/3.81.112#DEGA_BACSUDegradation Activator
581#11#SCRR_STRMUSucrose Operon Repressor
582#11#REGA_CLOABTranscription Regulatory Protein Rega
10#SKN7_YEASTTranscription Factor Skn7 (Pos9 Protein)
11#VIRG_AGRT5Virg Regulatory Protein
1.4.3/3.14.213#RGX3_MYCTUSensory Transduction Protein REGX3
190#PFER_PSEAETranscriptional Activator Protein Pfer
366#PETR_RHOCAPetr Protein
2.45.1/7.7.1203#153#HC_RATAlpha-1-Microglobulin/Trypsin Inhibitor
2.5.1/6.5.1E1.9.3COX2_ZOOANCytochrome C Oxidase Ii (1.9.3.1)
3.29.1/3.48.1E2.7.1F26_RANCA6-Phosphofructo-2-Kinase (2.7.1.105)
3.47.1/5.17.11#YED0_YEASTHeat Shock Protein 70 Homolog YEL030w
1#83#GR73_MAIZEIg-Binding Protein