Table 2.

Most Versatile Single-Domain Superfamilies

No.func No.prot Sfam comb Function SWISS-PROT ID SWISS-PROT function
E1.11.1GSHP_RATPlasma Glutathione Peroxidase (1.11.1.9)
263#DYL5_CHLREDynein, Flagellar Outer Arm–C. reinhardtii
D260#BSAA_BACSUGlutathione Peroxidase Homolog Bsaa
268#REHY_TORRURehydrin–Tortula ruralis (Moss)
11693.38.1266#PHOS_HUMANPhosducin (33 Kd Phototransducing Protein)
269#REHY_ORYSARad24 Protein–Oryza sativa (Rice)
272#THIO_BPT4Thioredoxin (Bacteriophage T4)
D271#272#TDX2_BRUMAThioredoxin Peroxidase 2
261#BTUE_ECOLIVitamin B12 Transport Periplasmic Protein Btue
342#BRAZ_PENBABrazzein–Pentadiplandra brazzeana
376#336#SCKK_TITSENeurotoxin Ts-Kapa (Tsk)–(Brazilian scorpion)
341#356#AF2B_SINALCysteine-Rich Antifungal Protein 2b (Afp2b)
10287.3.6343#DEFA_ZOPATDefensin, Isoforms B And C–Zophobas atratus
361#DMYC_DROMEDrosomycin Precursor (Cysteine-Rich Peptide)
361#376#SCX5_BUTEUInsectotoxin I5a–(Lesser Asian scorpion)
336#SCX3_LEIQHLeiuropeptide Iii–(Scorpion)
203#SIA1_SORBISmall-Pr Inhibitor Of Insect Alpha-Amylases
310#AB18_PEAAba-Responsive Protein Abr18–Garden Pea
311#DRR3_PEADisease Resistance Response Protein Pi49
7344.79.3231#MPAA_CORAVMajor Pollen Allergen Cor A 1,–Eu. Hazel
312#L18B_LUPLUProtein L1r18b (LIpr10.1b)
E3.1.–RNS2_PANGIRibonuclease 2 (3.1.–/–)–Panax Ginseng
314#SAM2_SOYBNStress-Induced Protein Sam22
184#CSF2_SHEEPColony-Stimulating Factor
381#564#184#IL4_RATInterleukin-4 (B-Cell Igg Diff. Factor)
7431.26.1185#LIF_HUMANLeukemia Inhibitory Factor (Lif)
187#PRL_ANGANProlactin Precursor (Prl)–
186#PLF3_MOUSEProliferin 3 Mitogen-Regulated
188#SOMA_PAROLSomatotropin (Growth Hormone)

[i] The most versatile superfamilies in single-domain proteins as determined from their functional description in SWISS-PROT, with some representatives. The keyword combinations in the fourth column were based either on the first three components of their EC numbers (for enzymes) or derived automatically by comparing the DE description line of SWISS-PROT entries to a list of synonymous keywords athttp://bioinfo.mbb.yale.edu/partslist/func. A keyword number starting with a D indicates an enzyme that does not have an assigned EC number in its description in SWISS-PROT.