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Table 1.

Exon–Intron Organization of the Human HERC2 Gene

Exon no.	cDNA position[i]	Exon first base[ii]	Intron–exon boundary	Exon size	Exon–intron boundary	Intron size[iii]
1	1	4708	GAGGCG	30	CGTCAGgtcctggcct	610
2	31	5348	ttacttgcagGCCTGA	103	ATACAGgtggggtttg	21847[iv]
3	134	27298	tcattgccagCTTGCA	115	GAAAAGgtaagggcct	6377[v]
4	249	33790	aattctgcagATGATA	135	AACCAGgtaatcttgt	12596
5	384	46521	tattttctagATGTGA	220	AAAAAGgtaacaataa	5062[vi]
6	604	51803	tcgtctgcagTTCCCG	101	GATCAGgtacggtccc	457
7	705	52361	gtgcgcccagGCGAGG	157	GACGGGgtgagttctt	1286
8	862	53804	ttcatttcagGGATGT	111	GCTGAGgtgagggctg	507
9	973	54422	tctcctttagCCAAAT	172	ATGCACgtgagtgtca	1346
10	1145	55940	tcctttctagCTTTTG	174	CATAAGgtgtgtgtgc	1258
11	1319	57372	tatcttacagGGATCA	189	ACGCTGgtgagtgttc	631
12	1508	58192	ccttctttagGCCCCA	152	CACTGTgtatgtatcg	2490
13	1660	60834	tctccccaagGCCTTT	158	GCCATGgtacgtctgc	85
14	1818	61077	ctgtttgaagGCTCCA	114	AGAACGgtacgtagag	2448
15	1932	63639	tattttttagGGCAAG	252	TGCAAGgtgagtgcaa	1947
16	2184	65838	tcccttgtagGGAAGA	194	GCCCAGgtactgaata	3515
17	2378	69547	ttcctcttagAGCTTT	201	CTTCAGgtattcatga	743
18	2579	70491	ctcctttcagTTGCAT	229	GCGCAGgtgggcctgg	92
19	2808	70812	tctatttcagTTTCAG	125	ATCCAGgtatggcttt	1353
20	2933	72290	tgaattacagGATATT	179	TCTTAGgtaaatcgta	5603
21	3112	78072	tcctgtatagAAACAT	185	TTTCTAgtaagttgct	1653
22	3297	79910	cttcttcaagGTCCAG	156	TTACTGgtaccttttg	675
23	3453	80741	ttaaatgtagGTGTTC	186	TAATGGgtacggcgtc	7108[vii]
24	3639	88035	gtatatacagAGTCAT	171	TTCTTGgtaagattac	384
25	3810	88590	tttgtttcagCTCAGT	104	TTGGAGgtgaggctgt	1000
26	3914	89694	atttttccagCCTGAC	151	GTGCCAgtaagaaaat	2676
27	4065	92521	cattttccagAATGGC	215	GTGAAGgtgagctagg	273
28	4280	93009	tctgttgcagGACTTT	133	ATTTAGgtaaggagct	102
29	4413	93244	ctttttacagGTCATG	128	ATTAAGgtgatagatt	92
30	4541	93464	aactttgcagACTCAT	196	AGAGAGgtaagaatgt	2645
31	4737	96305	taaaacacagTTCCTA	134	CCCAAGgtgcagtatt	519
32	4871	96958	cctttgttagGACAAA	174	AAACAGgtaacatttg	77
33	5045	97209	tattttgcagTTGGAG	137	TATAGGgtaaaacgtt	113
34	5182	97459	tatttgaaagGGAACC	152	AGCTTGgtgagtcaat	785
35	5334	98396	tgctcattagGTATCC	192	TGATTGgtaggtctgc	6010[viii] [ix]
36	5526	104598	gctccatcagGCCCCA	188	GATCAGgtactcagag	1383
37	5714	106169	gctttctcagGATGGG	193	ACTCTGgtgggtgact	1780
38	5907	108142	ttttttttagAAGCCG	183	AGACATgtatggaatg	2686
39	6090	111011	cctcctgcagCTTCTC	182	AGGCAGgtaatgtgct	818
40	6272	112011	cttttatcagATCTTA	147	TCAGAGgtgggtggcc	383
41	6420	112541	tcctcctcagAGTCCA	197	GAAGGGgtgggtttgt	103
42	6617	112841	tctgcactagGCCCAG	231	AAACCAgtaggtgaac	1158
43	6848	114230	tcctctccagCTCCCT	139	TTGCAGgtcagtacat	1299
44	6987	115668	ccttccgcagGACAAG	144	ACACAGgtgtcttttt	4619
45	7131	120431	ttaaattcagATGATG	143	CTTGAGgtacagccat	3652
46	7274	124226	gtctgcccagGCTGCT	268	TGCCTGgtacttcgtt	97
47	7542	124591	cctctcttagGTGTGG	137	TCCATGgtcagtgcct	558
48	7679	125286	tttcttgcagTCTACT	99	ATTCAGgtgagtaatt	2686
49	7778	128071	ttaattctagGTGGGA	169	TTATAGgtgagcacat	97
50	7947	128337	acatctgtagGCTATC	126	TGAAAGgtaatattat	1808
51	8073	130271	tctgtcctagCTTTCA	109	GGTTACgtgagttatt	106
52	8182	130486	ttacaaatagGTGTGA	140	AACCAGgtatggcaga	>2015
53	8322	348	cacgaaatagGTCAGT	191	GGAAAGgtagcatcta	>800
54	8513		ttttctaaagCACTGG	106	TGTCAGgtaattcagt	82
55	8619		tttttcctagGTGGAA	92	ACAGAGgtaagtagct	>1200
56	8711		ttgtgtctagTATCAC	176	CGGAAGgtgagaacca	>1200
57	8887		gtttggttagCCTCAT	112	TCCAAGgtacggcctg	>1150
58	8999		tctgttgtagATAAAG	82	TTGCAGgtatgattat	110
59	9081		ttccttgcagTGACTG	144	ACTCAGgtacaagcca	>1100
60	9225		aatgttgcagGTGGCC	91	CAGAATgtaagggtac	291
61	9316		cttgttgtagGAACTG	178	AAAATGgtgattatac	181
62	9494		aattgagtagGTGAAA	82	ATGAAGgtgagtggct	86
63	9576		ttaaacctagGTTTGG	172	GACATGgtacgtaaac	>1000
64	9748		cttctctcagGGGAAA	145	GGGCAGgtaaggctgc	891
65	9893		tcgtaaacagGTGTAT	226	ACTTAGgtaacacaga	>1280
66	10119		cctcttatagGCGTGC	172	TGCCAGgtaggcttct	893
67	10291		gtcctgacagAGATGC	184	AGAGAGgtaaaagcga	578
68	10475		cttggactagATTGTT	141	AAAGAGgtgaagaggc	>1260
69	10616		tttgacttagGATGTT	192	CCACAGgtgagtctca	>1070
70	10808		tcctgaccagGTGGCA	154	TACCAGgtacaggggc	>6385
71	10962		tgtccttcagGTGCAG	108	GGTCAGgtaaggacag	1433
72	11070		cctcccgcagGCCGAG	132	CTGCTGgtaaggaagg	436
73	11202		tcattcacagGCCCTA	159	CCCTAGgtaaatgcca	85
74	11361		ctcatttcagCTGCCA	119	GCTTTGgtatggagca	904
75	11480		gtctccttagAGTTCT	126	TTTAAGgtaatgtttc	434
76	11606		gtgcctgcagGTACTG	156	GATGAGgtattgcatg	392
77	11762		ttttgtttagGTGGCT	116	GAACAGgttattatat	101
78	11878		tgtattgtagGCGACC	199	GGGAAGgtaagagctc	>12000
79	12077		cttttcttagCTGTAT	215	CAGAAGgtatgatgtg	>4000
80	12292		ttttttgcagTCCGTG	178	AAGCTGgtgaggaggc	391
81	12470		ttctctgaagGTGGAG	162	ATGAAGgtatttccca	1507
82	12632		ccccctctagATTGAT	92	TACCTGgtacgcaaga	200
83	12724		ttgtgtgcagGGGCAA	140	AGGATGgtaggtaggg	4971
84	12864		cttcattcagGTGAGG	188	GCACAGgtgagtccgg	770
85	13052		tgtgttctagGTCCCC	198	GGAAAGgtattcaagt	2606
86	13250		tgtgttttagGAGGCG	84	ATCCAGgtagcacatg	>5000
87	13334		tcctctccagGTCAAA	142	TTGTGGgtgagaactt	>200
88	13476		tcccctgcagGTGAAT	195	TCCTGGgtgagctact	>2700
89	13671		gaatgatcagGTGTGT	113	AGTGAGgtaactccct	627
90	13784		tccttaaaagGTTGAT	191	CTATAGgttggtggtc	935
91	13975		tttcttccagACTCCA	106	ACGATGgtatgccgac	290
92	14081		cctcccgcagGTGTGT	213	ATCCAGgtaggctcct	1035
93	14294		tgctcaacagGTGTTG	997	TGACATaaaagtgtag[x]

[i] GenBank accession no. AF071172 (Ji et al. 1999).

[ii] Exons 1–52, GenBank accession no. AC004583 (PAC 778A2; exon 53, GenBank accession no. AQ388928 (BAC R-142A11 end).

[iii] (>) Minimum intron size based on contiguous flanking sequence.

[iv] (TA)₂₂ begins at position 25031^b.

[v] (CA)₁₅ begins at position 28775^b.

[vi] (TG)₁₈ begins at position 47153^b.

[vii] (PuT)₆₆ begins at position 81120^b. Pu = purine, with (GT)₂₀ the longest pure repeat.

[viii] (TCTG)₅ begins at position 102604^b.

[ix] (TG)₂₀ begins at position 102638^b.

[x] Polyadenylation takes place within or just 5′ of the four underlined adenine residues.