Table 1.

Sequence Identity of Loci Disrupted by Viral Insertion

Tumor Common site Candidate gene(s)[ii] Position[iii] Protein product Type[iv] VST ID[v]
18-18 Lvis1 Hex, Eg5 IGhomeobox transcription factor (Hex),B18018G1
18-28 Lvis1 IGkinesin-related spindle protein (Eg5)T18028G1
18-95 Lvis1 IGB18095G2
18-132 Lvis1 IGB18132G1
13-16 Lvis1 IGB13016G1
13-107 Lvis1 IGB13107G1
18-153 Lvis1 IGB/T18153G1
18-91 Lvis1 IGBS
27-28 Lvis1 IGBS
27-193 Lvis1 IGBS
27-16 Evi3 Evi3 UNunknownB27016G2
27-57 Evi3 UNB27057G8
27-183 Evi3 UNB27183G3
27-205 Evi3 UNB27205G8
27-207 Evi3 UNS27207G1
27-258 Evi3 UNB27258G3
27-222 Evi3 UNBS
27-172 Evi3 UNBS
18-49 N-myc N-myc 5′ Enuclear proteinB/T18049G1
18-109 N-myc 5′ EB/T18109G1
27-215 N-myc 3′ UTRT27215G1
18-60 Lvis2 unknownUNunknownS18060G6
18-67 Lvis2 UNS18067G2
27-110 Lvis2 UNT27110G1
18-72 Lvis3 unknownUNunknownB18072G2
18-132 Lvis3 UNB18132G2
10-60 Lvis4 unknownUNunknownB/T10060G2
27-266 Lvis4 UNB27266G1
18-34 Lvis5 Alx4Ppaired-type homeobox transcription factorT18034G2
27-110 Lvis5 UNTS
27-189 Lvis7 Rel 5′transcription factorB27189G3
27-17 Lvis7 UNSS
27-129 Lvis6 Hex 3′ UTRhomeobox transcription factorSS
27-268 Lvis6 3′ UTRB/TS
27-28 Lvis8[vi] CcnD3 CD cyclinB27028C5
27-178 Lvis9[vi] Sox4 3′ UTRHMG-box transcription factorB27178G1
27-94 Gfi1 Gfi1 3′ UTRzinc finger transcription factorT27094G3
18-123 Myc Myc Pnuclear proteinB/T18123G2
13-23 Notch1 Notch1 3′ UTRcell surface receptorT13023G1
27-16 N-ras 5′GTP-binding proteinB27016G1
27-107 Cd5 5′cell surface receptorS27107C1
27-3 Erp72 Pendoplasmic reticulum proteinB27003C4
18-33 IgH 3′ EB-cell surface receptorB/T18033G3
10-11 Mzfp2-related Czinc finger transcription factorB10011C3
27-28 RecQ5 CDNA helicaseB27028C2
18-97 Sip1 3′ UTRspliceosomal snRNP biogenesisS18097G2
27-3018S rRNAintronrRNAB27030G1
18-43 U96726 IGputative phosphoinositide 5-phosphatase type IIB18043G4
27-28 AI250289 NCI CGAP Lym 12 follicular lymphoma ESTB27028E1
27-3 N22410 ESTB27003E5
18-123 AI549667 ESTB/T18123E1
27-258 AA611619 ESTB27258E2
27-3 AA546050 ESTB27003E2
27-24 AI059755 ESTT27024E2
13-36 AA636183 ESTB13036E1
13-87 AA207479 ESTT13087E1
13-44 AI644018 ESTN.D.13044E1
13-53 AI615534 ESTB13053E1
13-45 AA990077 ESTS13045E1
13-37AA1614004ESTB13037E1

[i] Viral insertion sites identified using VISA or conventional Southern analysis are listed, except sites for which genes have not been identified (135 VSTs), or those representing endogenous insertion sites. All VISA products represent sequence 5′ of the proviral element (except Evi3 tags, which are 3′ insertion sites), such that each insertion is identified only once.

[ii] GenBank accession nos. are given for ESTs and genomic sequence contigs.

[iii] Location of inserted viral element in relation to candidate gene as determined by Blast sequence alignment. [(C) coding; (E) enhancer; (IG) intergenic; (P) promoter; (UN) unknown; (UTR) untranslated region].

[iv] Tumor cell type was determined by Southern analysis [(B) B cell; (T) T cell; (B/T) mixture of B and T cell; (S) progenitor or myeloid; (N.D.) not determined].

[v] Sequences have been deposited in GenBank, but can also be accessed at http://www.mouse-genome.bcm.tmc.edu/. [(S) insertion sites identified by conventional Southern analysis].

[vi] Viral insertions at this locus were identified in other tumor subsets, indicating that this is a common site.