Characteristics of the Parental Mouse Lines
| DU6i Mean ± s.d. (17 males) | DBA/2 Mean ± s.d. (20 males) | F2 Population[i] Mean ±s.d. (411 animals) | |
| Body composition | |||
| Body weight (g) | 68.6 ± 3.96 | 18.3 ± 1.6 | 31.05 ± 3.83 |
| Abdominal fat weight (mg) | 1801 ± 560 | 241 ± 58 | 486 ± 197 |
| Abdominal fat percentage (%) | 2.62 ± 0.74 | 1.31 ± 0.28 | 1.49 ± 0.50 |
| Muscle weight (mg) | 617 ± 42 | 240 ± 28 | 339 ± 52 |
| Liver weight (mg) | 4077 ± 520 | 930 ± 166 | 1745 ± 266 |
| Kidney weight (mg) | 882 ± 78 | 240 ± 28 | 386 ± 73 |
| Spleen weight (mg) | 275 ± 67 | 78 ± 13 | 156 ± 51 |
| Serum parameters | |||
| Leptin (ng/ml) | 21.16 ± 11.52 | 1.72 ± 0.56 | 5.55 ± 3.66 |
| Insulin (pmol/L) | 1651 ± 982 | <26 | 248 ± 139 |
| IGF-I (ng/ml) | 750 ± 151 | 238 ± 39 | 616 ± 121 |
[i] Individual values were adjusted for the fixed effects of sex, number of repeated parity, subfamily, and pupsize.