Table 3.

Known Genes Selected as Uniquely Expressed in Myeloid Cells

Cluster ID GenBank identity #ACC Pvalue
GS08362Granulocyte colony-stimulating factor receptor S71484 2.56E-17
GS00697Plasminogen activator inhibitor-2 (PAI-2) M24657 1.13E-09
GS01724Pleckstrin (P47) X07743 1.13E-09
GS01024Leukocyte adhesion protein/CD18 M15395 2.14E-08
GS01345Bactericidal permeability increasing protein (BPI) J04739 7.56E-06
GS08325Phosphatidylinositol 3-kinase p110delta U86453 7.56E-06
GS01990Secreted protein (I-309) M57502 7.56E-06
GS01200ICB-1 mRNA AF044896 1.42E-04
GS01719Myeloid cell nuclear differentiation antigen M81750 1.42E-04
GS01202Neutrophil oxidase factor (NCF2)/p67-phox U00788 1.42E-04
GS00779Wegener's granulomatosis autoantigen proteinase 3 M97911 1.42E-04
GS01687c-raf-1 proto-oncogene L00212 2.68E-03
GS01000EVI2B3P M60830 2.68E-03
GS08337Grancalcin (neutrophil monocyte Ca binder) M81637 2.68E-03
GS00610Beige protein homolog (chs) U67615 2.68E-03
GS01164Differentiation antigen (CD33) M23197 2.68E-03
GS08512Monocytic leukemia zinc finger protein U47742 2.68E-03
GS01229Migration inhibitory factor-related protein 8 M21005 2.68E-03
GS01963Type II interleukin-1 receptor antagonist (IL-1ra3) AF057168 2.68E-03

[i] Gene signature (GS) clusters were selected by the criteria that have probability of uncontrolled expression between myeloid cells (HL60, HL60/DMSO, HL60/TPA, granulocytes) and the remaining tissues less than 0.5%. P values represent the probabilities of each gene with uncontrolled expression between two sets of libraries (see Methods for calculations). Along with these known genes, 28 GSs for novel genes as follows were selected: GS01371, GS01572, GS08424, GS01582, GS01553, GS01965, GS01356, GS00656, GS08595, GS01922, GS08435, GS01123, GS00963, GS01383, GS08551, GS08572, GS01352, GS01109, GS01561, GS08460, GS05157, GS00549, GS01251, GS00627, GS08477, GS08379, GS01458, GS01987. For sequences, refer to http://bodymap.ims.u-tokyo.ac.jp.