Species, Disease Caused, Genome Size, and Number of Open Reading Frames of the Bacterial and Archaeal Genomes Used
| Species | Disease caused | Genome size (bp) | Number of open reading frames | HGT | Percentage HGT | GC+ | GC− |
| Proteobacteria | |||||||
| Escherichia coli | · · · | 4,639,221 | 4289 | 381 | 9.62 | 68 | 258 |
| Haemophilus influenzae | Pneumonia | 1,830,138 | 1709 | 96 | 6.19 | 31 | 33 |
| Helicobacter pylori 26695 | Ulcer | 1,667,867 | 1553 | 89 | 6.41 | 0 | 68 |
| Helicobacter pylori J99 | Ulcer | 1,643,831 | 1491 | 80 | 5.81 | 5 | 59 |
| Rickettsia prowazekii | Typhus | 1,111,523 | 834 | 28 | 3.62 | 10 | 8 |
| Gram-positive bacteria | |||||||
| Bacillus subtilis | · · · | 4,214,814 | 4100 | 537 | 14.47 | 85 | 402 |
| Mycoplasma genitalium | Urethritis | 580,074 | 480 | 67 | 14.47 | 46 | 19 |
| Mycoplasma pneumoniae | Pneumonia | 816,394 | 677 | 39 | 5.93 | 0 | 32 |
| Mycobacterium tuberculosis | Tuberculosis | 4,411,529 | 3918 | 187 | 5.01 | 55 | 53 |
| Spirochaete | |||||||
| Borrelia burgdorferi | Lyme disease | 910,724 | 850 | 12 | 1.56 | 0 | 5 |
| Treponema pallidum | Syphilis | 1,138,011 | 1031 | 77 | 8.32 | 30 | 38 |
| Chlamydiae | |||||||
| Chlamydia trachomatis | Trachoma, epidymitis | 1,042,519 | 894 | 36 | 4.32 | 8 | 13 |
| Chlamydia pneumoniae | Pneumonia, bronchitis | 1,230,230 | 1052 | 55 | 5.70 | 28 | 16 |
| Aquifex aeolicus | · · · | 1,551,335 | 1522 | 72 | 4.84 | 6 | 43 |
| Deinococcus radiodurans | · · · | 2,648,638 | 2580 | 95 | 3.92 | 6 | 38 |
| Synechocystis PCC6803 | · · · | 3,573,470 | 3169 | 219 | 7.50 | 12 | 151 |
| Thermotoga maritima | · · · | 1,860,725 | 1846 | 198 | 11.63 | 69 | 100 |
| Ureaplasma urealyticum | Adverse pregnancy outcome, neonatal disease, and superative arthritis | 751,719 | 610 | 32 | 5.70 | 8 | 9 |
| Archaea | |||||||
| Aeropyrum pernix | · · · | 1,669,695 | 2694 | 370 | 14.01 | 108 | 203 |
| Archaeoglobus fulgidus | · · · | 2,178,400 | 2407 | 179 | 8.44 | 16 | 116 |
| Methanobacterium thermoautotrophicum | · · · | 1,751,377 | 1869 | 179 | 10.73 | 30 | 111 |
| Methanococcus jannaschii | · · · | 1,664,970 | 1715 | 77 | 5.00 | 18 | 38 |
| Pyrococcus abyssi | · · · | 1,765,118 | 1765 | 124 | 7.35 | 22 | 63 |
| Pyrococcus horikoshii | · · · | 1,738,505 | 2064 | 154 | 7.68 | 68 | 42 |
[i] Note: HGT is the total number of proposed transferred genes, GC+ and GC− are proposed transferred genes that belong to regions with a high or low G+C content, respectively. The percentage HGT was calculated by dividing the number of proposed transferred genes by the sum of nonproposed ones, excluding genes smaller than 300 bp, and proposed transferred genes.