Gene	Other gene name	Activity	location	ID	Role
UNG		U	12q24.11	NM_080911	Base excision repair (BER)
SMUG1		U	12q13.13	NM_014311	Base excision repair (BER)
MBD4		U or T opposite G at CpG sequences	3q21.3	NM_003925	Base excision repair (BER)
TDG		"U, T or ethenoC opposite G"	12q23.3	NM_003211	Base excision repair (BER)
OGG1		8-oxoG opposite C	3p25.3	NM_016821	Base excision repair (BER)
MUTYH	MYH	A opposite 8-oxoG	1p34.1	NM_012222	Base excision repair (BER)
NTHL1	NTH1	Ring-saturated or fragmented pyrimidines	16p13.3	NM_002528	Base excision repair (BER)
MPG		"3-meA, ethenoA, hypoxanthine"	16p13.3	NM_002434	Base excision repair (BER)
NEIL1		Removes thymine glycol	15q24.2	NM_024608	Base excision repair (BER)
NEIL2		Removes oxidative products of pyrimidines	8p23.1	NM_145043	Base excision repair (BER)
NEIL3		Removes oxidative products of pyrimidines	4q34	NM_018248	Base excision repair (BER)
APEX1	APE1	AP endonuclease	14q11.2	NM_001641	Other BER and strand break joining factors
APEX2		AP endonuclease	Xp11.21	NM_014481	Other BER and strand break joining factors
LIG3		DNA Ligase III	17q12	NM_013975	Other BER and strand break joining factors
XRCC1		LIG3 accessory factor	19q13.31	NM_006297	Other BER and strand break joining factors
PNKP		Converts some DNA breaks to ligatable ends	19q13.33	NM_007254	Other BER and strand break joining factors
APLF		Accessory factor for DNA end-joining	2p13.3	NM_173545	Other BER and strand break joining factors
HMCES		Reacts with AP sites	3q21.3	NM_020187	Other BER and strand break joining factors
PARP1	ADPRT	Protects strand interruptions	1q42.12	NM_001618	Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA
PARP2	ADPRTL2	PARP-like enzyme	14q11.2	NM_005484	Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA
PARP3	ADPRTL3	PARP-like enzyme	3p21.1	NM_001003931	Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA
PARG		Poly(ADP-ribose) glycohydrolase	10q11.23	NM_003631	Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA
PARPBP		Binds PARP and modulates recombination	12q23.2	NM_001319988	Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA
MGMT		O6-meG alkyltransferase	10q26.3	NM_002412	Direct reversal of damage
ALKBH2	ABH2	1-meA dioxygenase	12q24.11	NM_001001655	Direct reversal of damage
ALKBH3	DEPC1	1-meA dioxygenase	11p11.2	NM_139178	Direct reversal of damage
TDP1		Removes 3'-tyrosylphosphate and 3'-phosphoglycolate from DNA; human disorder SCAN1	14q32.11	NM_018319	Repair of DNA-protein crosslinks
TDP2	TTRAP	5'- and 3'-tyrosyl DNA phosphodiesterase	6p22.3	NM_016614	Repair of DNA-protein crosslinks
SPRTN	Spartan	Reads ubiquitylation	1q42.12-q43	NM_032018	Repair of DNA-protein crosslinks
MSH2		Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition	2p21	NM_000251	Mismatch excision repair (MMR)
MSH3			5q14.1	NM_002439	Mismatch excision repair (MMR)
MSH6		"MSH2,MSH3,MSH6"	2p16.3	NM_000179	Mismatch excision repair (MMR)
MLH1		"MutL homologs, forming heterodimer"	3p22.3	NM_000249	Mismatch excision repair (MMR)
PMS2		"MLH1,PMS2"	7p22.1	NM_000535	Mismatch excision repair (MMR)
MSH4		MutS homologs specialized for meiosis	1p31.1	NM_002440	Mismatch excision repair (MMR)
MSH5		"MSH4,MSH5"	6p21.33	NM_002441	Mismatch excision repair (MMR)
MLH3		MutL homologs of unknown function	14q24.3	NM_014381	Mismatch excision repair (MMR)
PMS1			2q32.2	NM_000534	Mismatch excision repair (MMR)
PMS2P3	PMS2L3	"MLH3,PMS1,PMS2L3"	7q11.23	NM_005395	Mismatch excision repair (MMR)
HFM1		Helicase in meiotic-crossover formation	1p22.2	NM_001017975	Mismatch excision repair (MMR)
XPC		Binds DNA distortions	3p25.1	NM_004628	Nucleotide excision repair (NER)
RAD23B			9q31.2	NM_002874	Nucleotide excision repair (NER)
CETN2		"XPC,RAD23B,CETN2"	Xq28	NM_004344	Nucleotide excision repair (NER)
RAD23A		Substitutes for RAD23B	19p13.13	NM_005053	Nucleotide excision repair (NER)
XPA		Binds damaged DNA in preincision complex	9q22.33	NM_000380	Nucleotide excision repair (NER)
DDB1		Complex defective in XP group E	11q12.2	NM_001923	Nucleotide excision repair (NER)
DDB2	XPE	"DDB1,DDB2"	11p11.2	NM_000107	Nucleotide excision repair (NER)
RPA1		Binds DNA in preincision complex	17p13.3	NM_002945	Nucleotide excision repair (NER)
RPA2			1p35.3	NM_002946	Nucleotide excision repair (NER)
RPA3		"RPA1,RPA2,RPA3"	7p21.3	NM_002947	Nucleotide excision repair (NER)
TFIIH		Catalyzes unwinding in preincision complex		NM_005316	Nucleotide excision repair (NER)
ERCC3	XPB	3' to 5' DNA helicase	2q14.3	NM_000122	Nucleotide excision repair (NER)
ERCC2	XPD	5' to 3' DNA helicase	19q13.32	NM_000400	Nucleotide excision repair (NER)
GTF2H1		Core TFIIH subunit p62	11p15.1	NM_005316	Nucleotide excision repair (NER)
GTF2H2		Core TFIIH subunit p44	5q13.2	NM_001515	Nucleotide excision repair (NER)
GTF2H3		Core TFIIH subunit p34	12q24.31	NM_001516	Nucleotide excision repair (NER)
GTF2H4		Core TFIIH subunit p52	6p21.33	NM_001517	Nucleotide excision repair (NER)
GTF2H5	TTDA	Core TFIIH subunit p8	6p25.3	NM_207118	Nucleotide excision repair (NER)
GTF2E2		"TFIIE subunit, mutated in TTD"	8p12	NM_002095	Nucleotide excision repair (NER)
CDK7		Kinase subunits of TFIIH	5q13.2	NM_001799	Nucleotide excision repair (NER)
CCNH			5q14.3	NM_001239	Nucleotide excision repair (NER)
MNAT1		"CDK7,CCNH,MNAT1"	14q23.1	NM_002431	Nucleotide excision repair (NER)
ERCC5	XPG	3' incision	13q33.1	NM_000123	Nucleotide excision repair (NER)
ERCC1		5' incision DNA binding subunit	19q13.32	NM_001983	Nucleotide excision repair (NER)
ERCC4	XPF	5' incision catalytic subunit	16p13.12	NM_005236	Nucleotide excision repair (NER)
LIG1		DNA ligase	19q13.32	NM_000234	Nucleotide excision repair (NER)
ERCC8	CSA	Cockayne syndrome and UV-Sensitive Syndrome; Needed for transcription-coupled NER	5q12.1	NM_000082	Nucleotide excision repair (NER)
ERCC6	CSB		10q11.23	NM_000124	Nucleotide excision repair (NER)
UVSSA	KIAA1530	"ERCC8,ERCC6,UVSSA"	4p16.3	NM_020894	Nucleotide excision repair (NER)
XAB2	HCNP	"Pre-mRNA splicing; Associates with PRPF19, CSA, CSB"	19p13.2	NM_020196	Nucleotide excision repair (NER)
MMS19		Iron-sulfur cluster loading and transport	10q24.1	NM_022362	Nucleotide excision repair (NER)
RAD51		Homologous pairing	15q15.1	NM_002875	Homologous recombination
RAD51B		Rad51 homolog	14q24.1	NM_002877	Homologous recombination
RAD51D		Rad51 homolog	17q12	NM_002878	Homologous recombination
HELQ	HEL308	DNA helicase in RAD51 paralog complex	4q21.23	NM_133636	Homologous recombination
SWI5		Accessory factor for loading RAD51	9q34.11	NM_001040011	Homologous recombination
SWSAP1		"Shu subunits, RAD51 recruitment"	19p13.2	NM_175871	Homologous recombination
ZSWIM7	SWS1		17p12	NM_001042697	Homologous recombination
SPIDR		"SWSAP1,ZSWIM7,SPIDR,PDS5B"	8q11.21	NM_001080394	Homologous recombination
PDS5B			13q13.1	NM_015032	Homologous recombination
DMC1		"Rad51 homolog, meiosis"	22q13.1	NM_007068	Homologous recombination
XRCC2		DNA break and crosslink repair	7q36.1	NM_005431	Homologous recombination
XRCC3		"XRCC2,XRCC3"	14q32.33	NM_005432	Homologous recombination
RAD52		Accessory factors for recombination	12p13.33	NM_134424	Homologous recombination
RAD54L			1p34.1	NM_003579	Homologous recombination
RAD54B		"RAD52,RAD54L,RAD54B"	8q22.1	NM_012415	Homologous recombination
BRCA1		"Accessory factor for transcription and recombination, E3 Ubiquitin ligase"	17q21.31	NM_007294	Homologous recombination
BARD1		BRCA1-associated	2q35	NM_000465	Homologous recombination
ABRAXAS1		In BRCA1 A complex	4q21.23	NM_139076	Homologous recombination
PAXIP1	PTIP	MDC1 paralog in 53BP1 pathway	7q36.2	NM_007349	Homologous recombination
SMC5		Recruit cohesion during HR	9q21.12	NM_015110	Homologous recombination
SMC6		"SMC5,SMC6"	2p24.2	NM_001142286	Homologous recombination 
SHLD1		Suppressing end-resection	20p12.3	NM_001303477	Homologous recombination
SHLD2			10q23.2	NM_001330112	Homologous recombination
SHLD3		"SHLD1,SHLD2,SHLD3"	5q12.3	NM_001365341	Homologous recombination
SEM1	"SHFM1,DSS1"	BRCA2 associated	7q21.3	NM_006304	Homologous recombination
RAD50		"ATPase in complex with MRE11A, NBS1"	5q23.3	NM_005732	Homologous recombination
MRE11A		"3' exonuclease, defective in ATLD (ataxia-telangiectasia-like disorder)"	11q21	NM_005590	Homologous recombination
NBN	NBS1	Mutated in Nijmegen breakage syndrome	8q21.3	NM_002485	Homologous recombination
RBBP8	CtIP	Promotes DNA end resection	18q11.2	NM_002894	Homologous recombination
MUS81		Subunits of structure-specific DNA nuclease	11q13.1	NM_025128	Homologous recombination
EME1	MMS4L		17q21.33	NM_152463	Homologous recombination
EME2		"MUS81,EME1,EME2"	16p13.3	NM_001257370	Homologous recombination
SLX1A	GIYD1	"Subunit of SLX1-SLX4 structure-specific nuclease, two identical tandem genes in the human genome"	16p11.2	NM_001014999	Homologous recombination
SLX1B	GIYD2	"SLX1A,SLX1B"	16p11.2	NM_024044	Homologous recombination
GEN1		Nuclease cleaving Holliday junctions	2p24.2	NM_182625	Homologous recombination
FANCA		FANCA	16q24.3	NM_000135	Fanconi anemia
FANCB		FANCB	Xp22.31	NM_152633	Fanconi anemia
FANCC		FANCC	9q22.32	NM_000136	Fanconi anemia
BRCA2	FANCD1	"Cooperation with RAD51, essential function"	13q13.1	NM_000059	Fanconi anemia
FANCD2		Target for monoubiquitination	3p25.3	NM_033084	Fanconi anemia
FANCE		FANCE	6p21.31	NM_021922	Fanconi anemia
FANCF		FANCF	11p14.3	NM_022725	Fanconi anemia
FANCG	XRCC9	FANCG	9p13.3	NM_004629	Fanconi anemia
FANCI	KIAA1794	target for monoubiquitination	15q26.1	NM_018193	Fanconi anemia
BRIP1	FANCJ	"DNA helicase, BRCA1-interacting"	17q23	NM_032043	Fanconi anemia
FANCL		FANCL	2p16.1	NM_018062	Fanconi anemia
FANCM		helicase / translocase	14q21.3	NM_020937	Fanconi anemia
PALB2	FANCN	Co-localizes with BRCA2 (FANCD1)	16p12.1	NM_024675	Fanconi anemia
RAD51C	FANCO	"Rad51 homolog,FANCO"	17q23.2	NM_002876	Fanconi anemia
SLX4	FANCP	"nuclease subunit / scaffold SLX4,FANCP"	16p13.3	NM_032444	Fanconi anemia
FAAP20	C1orf86	FANCA - associated	1p36.33	NM_182533	Fanconi anemia
FAAP24	C19orf40	FAAP24	19q13.11	NM_152266	Fanconi anemia
FAAP100		Part of FA core complex	17q25.3	NM_025161	Fanconi anemia
UBE2T	FANCT	E2 ligase for FANCL	1q32.1	NM_014176	Fanconi anemia
XRCC6	Ku70	DNA end binding subunit	22q13.2	NM_001469	Non-homologous end-joining
XRCC5	Ku80	DNA end binding subunit	2q35	NM_021141	Non-homologous end-joining
PRKDC		DNA-dependent protein kinase catalytic subunit	8q11.21	NM_006904	Non-homologous end-joining
LIG4		Ligase	13q33.3	NM_002312	Non-homologous end-joining
XRCC4		Ligase accessory factor	5q14.2	NM_003401	Non-homologous end-joining
DCLRE1C	Artemis	Nuclease	10p13	NM_022487	Non-homologous end-joining
NHEJ1	"XLF, Cernunnos"	End-joining factor	2q35	NM_024782	Non-homologous end-joining
NUDT1	MTH1	8-oxoGTPase	7p22.3	NM_002452	Modulation of nucleotide pools
DUT		dUTPase	15q21.1	NM_001948	Modulation of nucleotide pools
RRM2B	p53R2	p53-inducible ribonucleotide reductase small subunit 2 homolog	8q22.3	NM_015713	Modulation of nucleotide pools
PARK7	DJ-1	Guanine glycation repair	1p36.23	NM_007262	Modulation of nucleotide pools
DNPH1		Hydrolase for 5-hydroxymethyl deoxyuridine	6p21.1	NM_006443	Modulation of nucleotide pools
NUDT15	MTH2	Hydrolysis of thiopurines?	13q14.2	NM_018283	Modulation of nucleotide pools
NUDT18	MTH3	Hydrolysis of 8-hydroxypurine diphosphates	8p21.3	NM_024815	Modulation of nucleotide pools
POLA1		DNA synthesis at resected ends	Xp22.1-p21.3	NM_001330360	DNA polymerases
POLB		BER in nuclear DNA	8p11.21	NM_002690	DNA polymerases
POLD1		Pol delta subunits	19q13.33	NM_002691	DNA polymerases
POLD2		"POLD1 (catalytic subunit),POLD2 (Also subunit of pol zeta),"	7p13	NM_001127218	DNA polymerases
POLD3			11q13.4	NM_006591	DNA polymerases
POLD4		"POLD3 (Also subunit of pol zeta),POLD4 (auxiliary subunit)"	11q13.2	NM_021173	DNA polymerases
POLE	POLE1	Pol epsilon subunits	12q24.33	NM_006231	DNA polymerases
POLE2			14q21.3	NM_002692	DNA polymerases
POLE3		"POLE1,POLE2,POLE3,POLE4"	9q32	NM_017443	DNA polymerases
POLE4			2p12	NM_019896	DNA polymerases
REV3L	POLZ	"DNA pol zeta catalytic subunit, essential function"	6q21	NM_002912	DNA polymerases
MAD2L2	REV7	DNA pol zeta and shieldin subunit	1p36.22	NM_006341	DNA polymerases
REV1	REV1L	dCMP transferase	2q11.2	NM_016316	DNA polymerases
POLG		Mitochondrial DNA repair and replication	15q26.1	NM_002693	DNA polymerases
POLH		xeroderma pigmentosum (XP) variant	6p21.1	NM_006502	DNA polymerases
POLI	RAD30B	Lesion bypass	18q21.2	NM_007195	DNA polymerases
POLQ		TMEJ (alt-EJ)	3q13.33	NM_199420	DNA polymerases
POLK	DINB1	Lesion bypass and NER	5q13.3	NM_016218	DNA polymerases
POLL		Gap-filling during non-homologous end-joining	10q24.32	NM_013274	DNA polymerases
POLM		Gap filling during non-homologous end-joining	7p13	NM_013284	DNA polymerases
POLN	POL4P	Lesion bypass / recombination?	4p16.3	NM_181808	DNA polymerases
PRIMPOL		Primase and DNA-directed polymerase	4q35.1	NM_152683	DNA polymerases
DNTT		Terminal transferase	10q24.1	NM_004088	DNA polymerases
FEN1	Dnase IV	5' nuclease	11q12.2	NM_004111	Editing and processing nucleases
FAN1	MTMR15	5' nuclease interacting with FANCD2	15q13.2	NM_014967	Editing and processing nucleases
TREX1		3' exonuclease	3p21.31	NM_033629	Editing and processing nucleases
TREX2		3' exonuclease	Xq28	NM_080701	Editing and processing nucleases
EXO1	HEX1	5' exonuclease	1q43	NM_003686	Editing and processing nucleases
APTX	aprataxin	Processing of DNA single-strand interruptions	9p21.1	NM_175073	Editing and processing nucleases
SPO11		endonuclease	20q13.32	NM_012444	Editing and processing nucleases
ENDOV		incision 3' of hypoxanthine and uracil in DNA and inosine in RNA	17q25.3	NM_173627	Editing and processing nucleases
DNA2		Seckel Syndrome 8	10q21.3	NM_001080449	Editing and processing nucleases
DCLRE1A	SNM1A	"5'-3' exonuclease, DNA crosslink repair"	10q25.3	NM_014881	Editing and processing nucleases
DCLRE1B	SNM1B	"5' - 3' exonuclease, APOLLO"	1p13.2	NM_022836	Editing and processing nucleases
EXO5		exonuclease	1p34.2	NM_001346946	Editing and processing nucleases
UBE2A	RAD6A	Ubiquitin-conjugating enzyme	Xq24-q25	NM_003336	Ubiquitination and modification
UBE2B	RAD6B	Ubiquitin-conjugating enzyme	5q31.1	NM_003337	Ubiquitination and modification
RAD18		E3 ubiquitin ligase	3p25.3	NM_020165	Ubiquitination and modification
SHPRH		"E3 ubiquitin ligase, SWI/SNF related, homolog ofS. cerevisiaeRad5"	6q24.3	NM_001042683	Ubiquitination and modification
HLTF	SMARCA3	"E3 ubiquitin ligase, SWI/SNF related, homolog ofS. cerevisiaeRad5"	3q25.1-q26.1	NM_003071	Ubiquitination and modification
RNF168		E3 ubiquitin ligase for DSB repair; ATM-like and RIDDLE syndrome	3q29	NM_152617	Ubiquitination and modification
RNF8		E3 ubiquitin ligase for DSB repair	6p21.2	NM_003958	Ubiquitination and modification
RNF4		E3 ubiquitin ligase	4p16.3	NM_001185009	Ubiquitination and modification
UBE2V2	MMS2	Ubiquitin-conjugating complex	8q11.21	NM_003350	Ubiquitination and modification
UBE2N	UBC13	"UBE2V2,UBE2N"	12q22	NM_003348	Ubiquitination and modification
USP1		"Ubiquitin-specific protease for FANCD2, PCNA"	1p31.3	NM_003368	Ubiquitination and modification
WDR48		Necessary for USP1 activity	3p22.2	NM_020839	Ubiquitination and modification
HERC2		Control of several DNA repair factors	15q13.1	NM_004667	Ubiquitination and modification
H2AX	H2AFX	"Histone, phosphorylated after DNA damage"	11q23.3	NM_002105	Chromatin Structure and Modification
CHAF1A	CAF1	Chromatin assembly factor	19p13.3	NM_005483	Chromatin Structure and Modification
SETMAR	METNASE	DNA damage-associated histone methylase and nuclease	3p26	NM_006515	Chromatin Structure and Modification
ATRX		"Chromatin remodeling, transcription factor"	Xq21.1	NM_000489	Chromatin Structure and Modification
BLM		Bloom syndrome helicase	15q26.1	NM_000057	Genes defective in diseases associated with sensitivity to DNA damaging agents
RMI1		In BLM-TOP3A complex	9q21.32	NM_001358291	Genes defective in diseases associated with sensitivity to DNA damaging agents
TOP3A		Topoisomerase IIIa	17p11.2	NM_004618	Genes defective in diseases associated with sensitivity to DNA damaging agents
WRN		Werner syndrome helicase / 3' - exonuclease	8p12	NM_000553	Genes defective in diseases associated with sensitivity to DNA damaging agents
RECQL4		Rothmund-Thompson syndrome	8q24.3	NM_004260	Genes defective in diseases associated with sensitivity to DNA damaging agents
ATM		ataxia telangiectasia	11q22.3	NM_000051	Genes defective in diseases associated with sensitivity to DNA damaging agents
MPLKIP	TTDN1	non-photosensitive form of trichothiodystrophy	7p14	NM_138701	Genes defective in diseases associated with sensitivity to DNA damaging agents
RPA4		Similar to RPA2	Xp21.33	NM_013347	Other identified genes with known or suspected DNA repair function
PRPF19	PSO4	Pre-mRNA splicing; DNA crosslink repair; binding to SETMAR	11q12.2	NM_014502	Other identified genes with known or suspected DNA repair function
RECQL	RECQ1	DNA helicase	12p12.1	NM_002907	Other identified genes with known or suspected DNA repair function
RECQL5		DNA helicase	17q25.1	NM_001003715	Other identified genes with known or suspected DNA repair function
RDM1	RAD52B	Similar to RAD52	17q12	NM_145654	Other identified genes with known or suspected DNA repair function
NABP2	SSB1	Single-stranded DNA binding protein (ATM / MRN pathway)	12q13.3	NM_024068	Other identified genes with known or suspected DNA repair function
ATR		ATM- and PI-3K-like essential kinase	3q23	NM_001184	Other conserved DNA damage response genes
ATRIP		ATR-interacting protein	3p21.31	NM_130384	Other conserved DNA damage response genes
MDC1		Mediator of DNA damage checkpoint	6p21.3	NM_014641	Other conserved DNA damage response genes
PCNA		Sliding clamp for pol delta and pol epsilon	20p12.3	NM_002592	Other conserved DNA damage response genes
RAD1		subunits of PCNA-like sensor of damaged DNA	5p13.2	NM_002853	Other conserved DNA damage response genes
RAD9A			11q13.2	NM_004584	Other conserved DNA damage response genes
HUS1		"RAD1,RAD9,HUS1"	7p12.3	NM_004507	Other conserved DNA damage response genes
RAD17	RAD24	RFC-like DNA damage sensor	5q13.2	NM_002873	Other conserved DNA damage response genes
CHEK1		Effector kinases	11q24.2	NM_001274	Other conserved DNA damage response genes
CHEK2		"CHEK1,CHEK2"	22q12.1	NM_007194	Other conserved DNA damage response genes
TP53		Regulation of the cell cycle	17p13.1	NM_000546	Other conserved DNA damage response genes
TP53BP1	53BP1	chromatin-binding checkpoint protein	15q15-q21	NM_001141980	Other conserved DNA damage response genes
RIF1		suppressor of 5'-end-resection	2q23.3	NM_001177665	Other conserved DNA damage response genes
TOPBP1		DNA damage checkpoint control	3q22.1	NM_007027	Other conserved DNA damage response genes
CLK2		S-phase check point and biological clock protein	1q21	NM_003993	Other conserved DNA damage response genes
PER1		S-phase check point and biological clock protein	17p12	NM_002616	Other conserved DNA damage response genes
