chrI	334	649	334	649	+	YAL069W	YAL069W		334,	649,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	537	792	537	792	+	YAL068W-A	YAL068W-A		537,	792,	Dubious open reading frame unlikely to encode a protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrI	1806	2169	1806	2169	-	PAU8	YAL068C		1806,	2169,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
chrI	2479	2707	2479	2707	+	YAL067W-A	YAL067W-A		2479,	2707,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrI	7234	9016	7234	9016	-	SEO1	YAL067C		7234,	9016,	Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily  mutation confers resistance to ethionine sulfoxide
chrI	10090	10399	10090	10399	+	YAL066W	YAL066W		10090,	10399,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	11564	11951	11564	11951	-	YAL065C	YAL065C		11564,	11951,	Putative protein of unknown function  has homology to FLO1  possible pseudogene
chrI	12045	12426	12045	12426	+	YAL064W-B	YAL064W-B		12045,	12426,	Fungal-specific protein of unknown function
chrI	13362	13743	13362	13743	-	YAL064C-A	YAL064C-A		13362,	13743,	Putative protein of unknown function  null mutant is sensitive to expression of the top1-T722A allele  not an essential gene
chrI	21565	21850	21565	21850	+	YAL064W	YAL064W		21565,	21850,	Protein of unknown function  may interact with ribosomes, based on co-purification experiments
chrI	22394	22685	22394	22685	-	YAL063C-A	YAL063C-A		22394,	22685,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrI	23999	27968	23999	27968	-	FLO9	YAL063C		23999,	27968,	Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
chrI	31566	32940	31566	32940	+	GDH3	YAL062W		31566,	32940,	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate  rate of alpha-ketoglutarate utilization differs from Gdh1p  expression regulated by nitrogen and carbon sources
chrI	33447	34701	33447	34701	+	BDH2	YAL061W		33447,	34701,	Putative medium-chain alcohol dehydrogenase with similarity to BDH1  transcription induced by constitutively active PDR1 and PDR3
chrI	35154	36303	35154	36303	+	BDH1	YAL060W		35154,	36303,	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin  enhances use of 2,3-butanediol as an aerobic carbon source
chrI	36495	36918	36495	36918	-	YAL059C-A	YAL059C-A		36495,	36918,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene ECM1/YAL059W
chrI	36508	37147	36508	37147	+	ECM1	YAL059W		36508,	37147,	Pre-ribosomal factor involved in 60S ribosomal protein subunit export  associates with the pre-60S particle  shuttles between the nucleus and cytoplasm
chrI	37463	38972	37463	38972	+	CNE1	YAL058W		37463,	38972,	Calnexin  integral membrane ER chaperone involved in folding and quality control of glycoproteins  chaperone activity is inhibited by Mpd1p, with which Cne1p interacts  24% identical to mammalian calnexin  Ca+ binding not yet shown in yeast
chrI	38695	39046	38695	39046	-	YAL056C-A	YAL056C-A		38695,	39046,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	39258	41901	39258	41901	+	GPB2	YAL056W		39258,	41901,	Multistep regulator of cAMP-PKA signaling  inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency  inhibits Ras activity through direct interactions with Ira1p/2p  regulated by G-alpha protein Gpa2p  homolog of Gpb1p
chrI	42176	42719	42176	42719	+	PEX22	YAL055W		42176,	42719,	Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation
chrI	42880	45022	42880	45022	-	ACS1	YAL054C		42880,	45022,	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation  expressed during growth on nonfermentable carbon sources and under aerobic conditions
chrI	45898	48250	45898	48250	+	FLC2	YAL053W		45898,	48250,	Putative FAD transporter  required for uptake of FAD into endoplasmic reticulum  involved in cell wall maintenance
chrI	48563	51707	48563	51707	+	OAF1	YAL051W		48563,	51707,	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p  activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
chrI	51854	52595	51854	52595	-	AIM2	YAL049C		51854,	52595,	Cytoplasmic protein involved in mitochondrial function or organization  null mutant displays reduced frequency of mitochondrial genome loss  potential Hsp82p interactor
chrI	52800	54789	52800	54789	-	GEM1	YAL048C		52800,	54789,	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology  cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria  not required for pheromone-induced cell death
chrI	54583	54913	54583	54913	+	YAL047W-A	YAL047W-A		54583,	54913,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	54988	56857	54988	56857	-	SPC72	YAL047C		54988,	56857,	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules  has roles in astral microtubule formation and stabilization
chrI	57028	57385	57028	57385	-	AIM1	YAL046C		57028,	57385,	Protein involved in mitochondrial function or organization  null mutant displays elevated frequency of mitochondrial genome loss
chrI	57487	57796	57487	57796	-	YAL045C	YAL045C		57487,	57796,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  almost completely overlaps YAL044W-A
chrI	57517	57850	57517	57850	+	YAL044W-A	YAL044W-A		57517,	57850,	Putative protein of unknown function  similar to S. pombe uvi31 which is a putative DNA repair protein
chrI	57949	58462	57949	58462	-	GCV3	YAL044C		57949,	58462,	H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF  also required for all protein lipoylation  expression is regulated by levels of 5,10-methylene-THF
chrI	58694	61052	58694	61052	-	PTA1	YAL043C		58694,	61052,	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends  involved in pre-tRNA processing  binds to the phosphorylated CTD of RNAPII
chrI	61230	61608	61230	61608	-	YAL042C-A	YAL042C-A		61230,	61608,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF ERV46/YAL042W  YAL042C-A is a non-essential gene
chrI	61315	62563	61315	62563	+	ERV46	YAL042W		61315,	62563,	Protein localized to COPII-coated vesicles, forms a complex with Erv41p  involved in the membrane fusion stage of transport
chrI	62839	65404	62839	65404	+	CDC24	YAL041W		62839,	65404,	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p  required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
chrI	65777	67520	65777	67520	-	CLN3	YAL040C		65777,	67520,	G1 cyclin involved in cell cycle progression  activates Cdc28p kinase to promote the G1 to S phase transition  plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2  regulated by phosphorylation and proteolysis
chrI	68715	69525	68715	69525	-	CYC3	YAL039C		68715,	69525,	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space  human ortholog may have a role in microphthalmia with linear skin defects (MLS)
chrI	71785	73288	71785	73288	+	CDC19	YAL038W		71785,	73288,	Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
chrI	72325	73300	72325	73300	-	YAL037C-B	YAL037C-B		72325,	73300,	Dubious open reading frame unlikely to encode a protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrI	73425	73518	73425	73518	-	YAL037C-A	YAL037C-A		73425,	73518,	Putative protein of unknown function
chrI	74019	74823	74019	74823	+	YAL037W	YAL037W		74019,	74823,	Putative protein of unknown function
chrI	75042	76152	75042	76152	-	RBG1	YAL036C		75042,	76152,	Member of the DRG family of GTP-binding proteins  associates with translating ribosomes  interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid
chrI	76426	79435	76426	79435	+	FUN12	YAL035W		76426,	79435,	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining  homolog of bacterial IF2
chrI	79488	79842	79488	79842	-	YAL034C-B	YAL034C-B		79488,	79842,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	79717	80587	79717	80587	+	MTW1	YAL034W-A		79717,	80587,	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules  critical to kinetochore assembly
chrI	80709	81951	80709	81951	-	FUN19	YAL034C		80709,	81951,	Non-essential protein of unknown function  expression induced in response to heat stress
chrI	82705	83227	82705	83227	+	POP5	YAL033W		82705,	83227,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
chrI	83334	84474	83334	84474	-	PRP45	YAL032C		83334,	84474,	Protein required for pre-mRNA splicing  associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p  orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
chrI	84668	84977	84668	84977	+	YAL031W-A	YAL031W-A		84668,	84977,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	84748	87031	84748	87031	-	GIP4	YAL031C		84748,	87031,	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation  potential Cdc28p substrate
chrI	87285	87752	87285	87752	+	SNC1	YAL030W		87285,87500,	87387,87752,	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane  proposed to be involved in endocytosis  member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
chrI	87854	92270	87854	92270	-	MYO4	YAL029C		87854,	92270,	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos  required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
chrI	92899	94486	92899	94486	+	FRT2	YAL028W		92899,	94486,	Tail-anchored ER membrane protein, interacts with homolog Frt1p  promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation  potential Cdc28p substrate
chrI	94686	95472	94686	95472	+	SAW1	YAL027W		94686,	95472,	Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing  green fluorescent protein (GFP)-fusion protein localizes to the nucleus
chrI	95385	95823	95385	95823	-	YAL026C-A	YAL026C-A		95385,	95823,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YAL027W and the verified gene DRS2
chrI	95629	99697	95629	99697	-	DRS2	YAL026C		95629,	99697,	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles  contributes to clathrin-coated vesicle formation and endocytosis  mutations in human homolog ATP8B1 result in liver disease
chrI	100224	101145	100224	101145	-	MAK16	YAL025C		100224,	101145,	Essential nuclear protein, constituent of 66S pre-ribosomal particles  required for maturation of 25S and 5.8S rRNAs  required for maintenance of M1 satellite double-stranded RNA of the L-A virus
chrI	101564	105872	101564	105872	-	LTE1	YAL024C		101564,	105872,	Protein similar to GDP/GTP exchange factors but without detectable GEF activity  required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
chrI	106271	108551	106271	108551	-	PMT2	YAL023C		106271,	108551,	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues  involved in ER quality control  acts in a complex with Pmt1p, can instead interact with Pmt5  target for new antifungal
chrI	108876	110430	108876	110430	-	FUN26	YAL022C		108876,	110430,	Vacuolar membrane transporter with broad nucleoside selectivity  may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
chrI	110845	113359	110845	113359	-	CCR4	YAL021C		110845,	113359,	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression  component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
chrI	113613	114615	113613	114615	-	ATS1	YAL020C		113613,	114615,	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA  has a potential role in regulatory interactions between microtubules and the cell cycle
chrI	114249	114819	114249	114819	+	YAL019W-A	YAL019W-A		114249,	114819,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	114918	118314	114918	118314	+	FUN30	YAL019W		114918,	118314,	Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity  has a role in silencing  potential Cdc28p substrate  authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
chrI	118563	119541	118563	119541	-	YAL018C	YAL018C		118563,	119541,	Putative protein of unknown function
chrI	120224	124295	120224	124295	+	PSK1	YAL017W		120224,	124295,	One of two (see also PSK2) PAS domain containing S/T protein kinases  coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
chrI	124306	124492	124306	124492	-	YAL016C-B	YAL016C-B		124306,	124492,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	124754	125069	124754	125069	-	YAL016C-A	YAL016C-A		124754,	125069,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	124878	126786	124878	126786	+	TPD3	YAL016W		124878,	126786,	Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p  required for cell morphogenesis and transcription by RNA polymerase III
chrI	126902	128102	126902	128102	-	NTG1	YAL015C		126902,	128102,	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair  acts in both nucleus and mitochondrion  creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress
chrI	128251	129019	128251	129019	-	SYN8	YAL014C		128251,	129019,	Endosomal SNARE related to mammalian syntaxin 8
chrI	129269	130487	129269	130487	+	DEP1	YAL013W		129269,	130487,	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
chrI	130798	131983	130798	131983	+	CYS3	YAL012W		130798,	131983,	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
chrI	132198	134076	132198	134076	+	SWC3	YAL011W		132198,	134076,	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A  required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
chrI	134183	135665	134183	135665	-	MDM10	YAL010C		134183,	135665,	Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins
chrI	135853	136633	135853	136633	+	SPO7	YAL009W		135853,	136633,	Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
chrI	136913	137510	136913	137510	+	FUN14	YAL008W		136913,	137510,	Mitochondrial protein of unknown function
chrI	137697	138345	137697	138345	-	ERP2	YAL007C		137697,	138345,	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p  member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
chrI	139502	141431	139502	141431	-	SSA1	YAL005C		139502,	141431,	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport  member of heat shock protein 70 (HSP70) family  forms a chaperone complex with Ydj1p  localized to the nucleus, cytoplasm, and cell wall  98% identical with Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
chrI	140759	141407	140759	141407	+	YAL004W	YAL004W		140759,	141407,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps verified gene SSA1/YAL005C
chrI	142173	143160	142173	143160	+	EFB1	YAL003W		142173,142619,	142253,143160,	Translation elongation factor 1 beta  stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle  part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
chrI	143706	147531	143706	147531	+	VPS8	YAL002W		143706,	147531,	Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization  component of the CORVET complex  required for localization and trafficking of the CPY sorting receptor  contains RING finger motif
chrI	147593	151166	147593	151166	-	TFC3	YAL001C		147593,151096,	151006,151166,	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC)  part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes  cooperates with Tfc6p in DNA binding
chrI	152256	153876	152256	153876	+	NUP60	YAR002W		152256,	153876,	Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP  involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1
chrI	154064	154724	154064	154724	-	ERP1	YAR002C-A		154064,	154724,	Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p  member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
chrI	155004	156285	155004	156285	+	SWD1	YAR003W		155004,	156285,	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres  WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
chrI	156753	158619	156753	158619	-	RFA1	YAR007C		156753,	158619,	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
chrI	158965	159793	158965	159793	+	SEN34	YAR008W		158965,	159793,	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p  Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
chrI	160596	164187	160596	164187	-	YAR009C	YAR009C		160596,	164187,	Retrotransposon TYA Gag and TYB Pol genes  in YARCTY1-1 TYB is mutant and probably non-functional
chrI	164543	165866	164543	165866	-	YAR010C	YAR010C		164543,	165866,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  in YARCTY1-1 TYB is mutant and probably non-functional
chrI	166741	168871	166741	168871	-	BUD14	YAR014C		166741,	168871,	Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein  inhibitor of the actin assembly factor Bnr1p (formin)  diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
chrI	169374	170295	169374	170295	+	ADE1	YAR015W		169374,	170295,	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis  red pigment accumulates in mutant cells deprived of adenine
chrI	170395	171703	170395	171703	-	KIN3	YAR018C		170395,	171703,	Nonessential serine/threonine protein kinase  possible role in DNA damage response
chrI	172210	175135	172210	175135	-	CDC15	YAR019C		172210,	175135,	Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase  promotes mitotic exit by directly switching on the kinase activity of Dbf2p  required for spindle disassembly after meiosis II
chrI	174997	175330	174997	175330	+	YAR019W-A	YAR019W-A		174997,	175330,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	176855	177023	176855	177023	-	PAU7	YAR020C		176855,	177023,	Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
chrI	179280	179820	179280	179820	-	YAR023C	YAR023C		179280,	179820,	Putative integral membrane protein, member of DUP240 gene family
chrI	183769	184477	183769	184477	+	UIP3	YAR027W		183769,	184477,	Putative integral membrane protein of unknown function  interacts with Ulp1p at the nuclear periphery  member of DUP240 gene family
chrI	184891	185596	184891	185596	+	YAR028W	YAR028W		184891,	185596,	Putative integral membrane protein, member of DUP240 gene family  GFP-fusion protein is induced in response to the DNA-damaging agent MMS
chrI	186320	186545	186320	186545	+	YAR029W	YAR029W		186320,	186545,	Member of DUP240 gene family but contains no transmembrane domains  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrI	186511	186853	186511	186853	-	YAR030C	YAR030C		186511,	186853,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
chrI	186835	187732	186835	187732	+	PRM9	YAR031W		186835,	187732,	Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding  member of DUP240 gene family
chrI	188106	188811	188106	188811	+	MST28	YAR033W		188106,	188811,	Putative integral membrane protein, involved in vesicle formation  forms complex with Mst27p  member of DUP240 gene family  binds COPI and COPII vesicles
chrI	190192	192256	190192	192256	+	YAT1	YAR035W		190192,	192256,	Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix  phosphorylated
chrI	192336	192417	192336	192417	-	YAR035C-A	YAR035C-A		192336,	192417,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching  predicted to have a role in cell budding based on computational "guilt by association" analysis
chrI	192618	196185	192618	196185	+	SWH1	YAR042W		192618,	196185,	Protein similar to mammalian oxysterol-binding protein  contains ankyrin repeats  localizes to the Golgi and the nucleus-vacuole junction
chrI	201466	201787	201466	201787	-	YAR047C	YAR047C		201466,	201787,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	203402	208016	203402	208016	+	FLO1	YAR050W		203402,	208016,	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant  similar to Flo5p
chrI	208366	208663	208366	208663	+	YAR053W	YAR053W		208366,	208663,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	217156	217492	217156	217492	-	YAR060C	YAR060C		217156,	217492,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	220197	220497	220197	220497	+	YAR064W	YAR064W		220197,	220497,	Putative protein of unknown function
chrI	221048	221660	221048	221660	+	YAR066W	YAR066W		221048,	221660,	Putative GPI protein
chrI	222405	222891	222405	222891	+	YAR068W	YAR068W		222405,	222891,	Fungal-specific protein of unknown function  induced in respiratory-deficient cells
chrI	224010	224304	224010	224304	-	YAR069C	YAR069C		224010,	224304,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	224562	224862	224562	224862	-	YAR070C	YAR070C		224562,	224862,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrI	225459	226863	225459	226863	+	PHO11	YAR071W		225459,	226863,	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway  induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
chrI	227741	228953	227741	228953	+	IMD1	YAR073W		227741,	228953,	Nonfunctional protein with homology to IMP dehydrogenase  probable pseudogene, located close to the telomere  is not expressed at detectable levels  YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae
chrI	228843	229317	228843	229317	+	YAR075W	YAR075W		228843,	229317,	Non-functional protein with homology IMP dehydrogenase  YAR073W/IMD1 and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae.
chrII	279	2658	279	2658	-	YBL113C	YBL113C		279,	2658,	Helicase-like protein encoded within the telomeric Y' element
chrII	645	1128	645	1128	+	YBL113W-A	YBL113W-A		645,	1128,	Dubious open reading frame unlikely to encode a protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrII	2581	2899	2581	2899	-	YBL112C	YBL112C		2581,	2899,	Putative protein of unknown function  YBL112C is contained within TEL02L
chrII	2906	5009	2906	5009	-	YBL111C	YBL111C		2906,4215,	4116,5009,	Helicase-like protein encoded within the telomeric Y' element
chrII	5789	6125	5789	6125	+	YBL109W	YBL109W		5789,	6125,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrII	7604	7733	7604	7733	-	PAU9	YBL108C-A		7604,	7733,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
chrII	8176	8482	8176	8482	+	YBL108W	YBL108W		8176,	8482,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	9267	9372	9267	9372	+	YBL107W-A	YBL107W-A		9267,	9372,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the Ty2 LTR YBLWdelta2
chrII	9960	10551	9960	10551	-	YBL107C	YBL107C		9960,	10551,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YBL107C is not an essential gene
chrII	10846	13879	10846	13879	-	SRO77	YBL106C		10846,	13879,	Protein with roles in exocytosis and cation homeostasis  functions in docking and fusion of post-Golgi vesicles with plasma membrane  homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor  interacts with SNARE protein Sec9p
chrII	14240	17696	14240	17696	-	PKC1	YBL105C		14240,	17696,	Protein serine/threonine kinase essential for cell wall remodeling during growth  localized to sites of polarized growth and the mother-daughter bud neck  homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
chrII	18176	21293	18176	21293	-	YBL104C	YBL104C		18176,	21293,	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole  has an N-terminal beta-propeller fold and a C-terminal RING motif  promoter contains multiple GCN4 binding sites
chrII	22075	23536	22075	23536	-	RTG3	YBL103C		22075,	23536,	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
chrII	24097	24745	24097	24745	+	SFT2	YBL102W		24097,	24745,	Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles  may be part of the transport machinery, but precise function is unknown  similar to mammalian syntaxin 5
chrII	24945	28299	24945	28299	-	ECM21	YBL101C		24945,	28299,	Protein involved in regulating the endocytosis of plasma membrane proteins  identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p  promoter contains several Gcn4p binding elements
chrII	28426	28546	28426	28546	+	YBL100W-C	YBL100W-C		28426,	28546,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrII	29934	35248	29934	35248	+	YBL100W-B	YBL100W-B		29934,31228,	31227,35248,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrII	29934	31251	29934	31251	+	YBL100W-A	YBL100W-A		29934,	31251,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrII	36988	37303	36988	37303	-	YBL100C	YBL100C		36988,	37303,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  almost completely overlaps the 5' end of ATP1
chrII	37052	38690	37052	38690	+	ATP1	YBL099W		37052,	38690,	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis  phosphorylated
chrII	39144	40527	39144	40527	+	BNA4	YBL098W		39144,	40527,	Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine  expression regulated by Hst1p  putative therapeutic target for Huntington disease
chrII	40830	43095	40830	43095	+	BRN1	YBL097W		40830,	43095,	Subunit of the condensin complex  required for chromosome condensation and for clustering of tRNA genes at the nucleolus  may influence multiple aspects of chromosome transmission
chrII	43173	43482	43173	43482	-	YBL096C	YBL096C		43173,	43482,	Non-essential protein of unknown function
chrII	43276	44089	43276	44089	+	YBL095W	YBL095W		43276,	44089,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrII	43764	44097	43764	44097	-	YBL094C	YBL094C		43764,	44097,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps uncharacterized ORF YBL095W
chrII	44255	44918	44255	44918	-	ROX3	YBL093C		44255,	44918,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme
chrII	45977	46370	45977	46370	+	RPL32	YBL092W		45977,	46370,	Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein  overexpression disrupts telomeric silencing
chrII	46564	47180	46564	47180	-	SCS22	YBL091C-A		46564,47146,	47058,47180,	Protein involved in regulation of phospholipid metabolism  homolog of Scs2p  similar to D. melanogaster inturned protein
chrII	47362	48628	47362	48628	-	MAP2	YBL091C		47362,	48628,	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides  function is partially redundant with that of Map1p
chrII	48824	49358	48824	49358	+	MRP21	YBL090W		48824,	49358,	Mitochondrial ribosomal protein of the small subunit  MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
chrII	49573	50953	49573	50953	+	AVT5	YBL089W		49573,	50953,	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
chrII	51018	59382	51018	59382	-	TEL1	YBL088C		51018,	59382,	Protein kinase primarily involved in telomere length regulation  contributes to cell cycle checkpoint control in response to DNA damage  functionally redundant with Mec1p  homolog of human ataxia telangiectasia (ATM) gene
chrII	59821	60739	59821	60739	-	RPL23A	YBL087C		59821,60697,	60193,60739,	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
chrII	61201	62602	61201	62602	-	YBL086C	YBL086C		61201,	62602,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
chrII	63875	66818	63875	66818	+	BOI1	YBL085W		63875,	66818,	Protein implicated in polar growth, functionally redundant with Boi2p  interacts with bud-emergence protein Bem1p  contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
chrII	67168	69445	67168	69445	-	CDC27	YBL084C		67168,	69445,	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
chrII	69712	70138	69712	70138	-	YBL083C	YBL083C		69712,	70138,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps verified ORF ALG3
chrII	69750	71127	69750	71127	-	ALG3	YBL082C		69750,	71127,	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
chrII	71865	72972	71865	72972	+	YBL081W	YBL081W		71865,	72972,	Non-essential protein of unknown function  null mutation results in a decrease in plasma membrane electron transport
chrII	73069	74695	73069	74695	-	PET112	YBL080C		73069,	74695,	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex  involved in the formation of Q-tRNAQ  mutation is functionally complemented by the bacterial GatB ortholog
chrII	75258	79767	75258	79767	+	NUP170	YBL079W		75258,	79767,	Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins  involved in nuclear envelope permeability and chromosome segregation  has similar to Nup157p  essential role, with Nup157p, in NPC assembly
chrII	80377	80731	80377	80731	-	ATG8	YBL078C		80377,	80731,	Component of autophagosomes and Cvt vesicles  undergoes conjugation to phosphatidylethanolamine (PE)  Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation
chrII	80896	81328	80896	81328	+	YBL077W	YBL077W		80896,	81328,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene ILS1/YBL076C
chrII	81042	84261	81042	84261	-	ILS1	YBL076C		81042,	84261,	Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
chrII	84498	86448	84498	86448	-	SSA3	YBL075C		84498,	86448,	ATPase involved in protein folding and the response to stress  plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation  member of the heat shock protein 70 (HSP70) family  localized to the cytoplasm
chrII	86721	87789	86721	87789	-	AAR2	YBL074C		86721,	87789,	Component of the U5 snRNP, required for splicing of U3 precursors  originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
chrII	87645	87957	87645	87957	+	YBL073W	YBL073W		87645,	87957,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the essential gene AAR2/YBL074C
chrII	88522	89125	88522	89125	-	RPS8A	YBL072C		88522,	89125,	Protein component of the small (40S) ribosomal subunit  identical to Rps8Bp and has similarity to rat S8 ribosomal protein
chrII	89457	89556	89457	89556	-	YBL071C-B	YBL071C-B		89457,	89556,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrII	89977	90226	89977	90226	+	KTI11	YBL071W-A		89977,	90226,	Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
chrII	90222	90531	90222	90531	-	YBL071C	YBL071C		90222,	90531,	Dubious open reading frame, predicted protein contains a peroxisomal targeting signal
chrII	90604	90925	90604	90925	-	YBL070C	YBL070C		90604,	90925,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	90740	92030	90740	92030	+	AST1	YBL069W		90740,	92030,	Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
chrII	91793	92030	91793	92030	+	YBL068W-A	YBL068W-A		91793,	92030,	Dubious open reading frame unlikely to encode a protein  identified by fungal homology and RT-PCR
chrII	92413	93394	92413	93394	+	PRS4	YBL068W		92413,	93394,	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis  one of five related enzymes, which are active as heteromultimeric complexes
chrII	93638	95882	93638	95882	-	UBP13	YBL067C		93638,	95882,	Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
chrII	96668	100115	96668	100115	-	SEF1	YBL066C		96668,	100115,	Putative transcription factor, has homolog in Kluyveromyces lactis
chrII	99962	100307	99962	100307	+	YBL065W	YBL065W		99962,	100307,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF SEF1/YBL066C  YBL065W is a non-essential gene
chrII	100370	101156	100370	101156	-	PRX1	YBL064C		100370,	101156,	Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides  reactivation requires Trr2p and glutathione  induced during respiratory growth and oxidative stress  phosphorylated
chrII	101885	105221	101885	105221	+	KIP1	YBL063W		101885,	105221,	Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning  functionally redundant with Cin8p for chromosomal but not plasmid functions
chrII	105307	105688	105307	105688	+	YBL062W	YBL062W		105307,	105688,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	105315	107406	105315	107406	-	SKT5	YBL061C		105315,	107406,	Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p  has similarity to Shc1p, which activates Chs3p during sporulation
chrII	107931	109995	107931	109995	+	YEL1	YBL060W		107931,	109995,	Guanine nucleotide exchange factor specific for Arf3p  localized to the bud neck and tip  required for localization of Arf3p to the bud neck and tip
chrII	110124	110539	110124	110539	-	CMC2	YBL059C-A		110124,110505,	110420,110539,	Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance  contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold
chrII	110593	111244	110593	111244	+	YBL059W	YBL059W		110593,110948,	110879,111244,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrII	111436	112708	111436	112708	+	SHP1	YBL058W		111436,	112708,	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p  interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
chrII	112800	113427	112800	113427	-	PTH2	YBL057C		112800,	113427,	One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases  negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins  dispensable for cell growth
chrII	113761	115168	113761	115168	+	PTC3	YBL056W		113761,	115168,	Type 2C protein phosphatase (PP2C)  dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress  dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p)  role in DNA damage checkpoint inactivation
chrII	115572	116829	115572	116829	-	YBL055C	YBL055C		115572,	116829,	3'-->5' exonuclease and endonuclease with a possible role in apoptosis  has similarity to mammalian and C. elegans apoptotic nucleases
chrII	117588	119166	117588	119166	+	TOD6	YBL054W		117588,	119166,	PAC motif binding protein involved in rRNA and ribosome biogenesis  subunit of the RPD3L histone deacetylase complex  Myb-like HTH transcription factor, similar to Dot6p  hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne
chrII	119334	119709	119334	119709	+	YBL053W	YBL053W		119334,	119709,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	119378	121874	119378	121874	-	SAS3	YBL052C		119378,	121874,	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing  homolog of the mammalian MOZ proto-oncogene  mutant has aneuploidy tolerance  sas3gcn5 double mutation is lethal
chrII	122752	124759	122752	124759	-	PIN4	YBL051C		122752,	124759,	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p  contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains  hyperphosphorylated in response to DNA damage
chrII	125124	126119	125124	126119	+	SEC17	YBL050W		125124,125270,	125154,126119,	Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy  stimulates the ATPase activity of Sec18p  has similarity to mammalian alpha-SNAP
chrII	126827	127244	126827	127244	+	MOH1	YBL049W		126827,	127244,	Protein of unknown function, has homology to kinase Snf7p  not required for growth on nonfermentable carbon sources  essential for survival in stationary phase
chrII	127298	127610	127298	127610	+	RRT1	YBL048W		127298,	127610,	Identified in a screen for mutants with increased levels of rDNA transcription  dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrII	127894	132040	127894	132040	-	EDE1	YBL047C		127894,	132040,	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
chrII	132423	133749	132423	133749	+	PSY4	YBL046W		132423,	133749,	Regulatory subunit of protein phosphatase PP4  presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint  localization is cell-cycle dependent and regulated by Cdc28p phosphorylation  required for cisplatin resistance  homolog of mammalian R2
chrII	134142	135516	134142	135516	-	COR1	YBL045C		134142,	135516,	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
chrII	135997	136366	135997	136366	+	YBL044W	YBL044W		135997,	136366,	Putative protein of unknown function  YBL044W is not an essential protein
chrII	136687	137461	136687	137461	+	ECM13	YBL043W		136687,	137461,	Non-essential protein of unknown function  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrII	138340	140260	138340	140260	-	FUI1	YBL042C		138340,	140260,	High affinity uridine permease, localizes to the plasma membrane  also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine  not involved in uracil transport
chrII	141246	141972	141246	141972	+	PRE7	YBL041W		141246,	141972,	Beta 6 subunit of the 20S proteasome
chrII	142111	142868	142111	142868	-	ERD2	YBL040C		142111,142846,	142749,142868,	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum  has a role in maintenance of normal levels of ER-resident proteins
chrII	143392	143572	143392	143572	+	YBL039W-B	YBL039W-B		143392,	143572,	Putative protein of unknown function
chrII	143988	145728	143988	145728	-	URA7	YBL039C		143988,	145728,	Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines  involved in phospholipid biosynthesis
chrII	144947	145031	144947	145031	-	YBL039C-A	YBL039C-A		144947,	145031,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF URA7  identified by expression profiling and mass spectrometry
chrII	146186	146885	146186	146885	+	MRPL16	YBL038W		146186,	146885,	Mitochondrial ribosomal protein of the large subunit
chrII	147208	150286	147208	150286	+	APL3	YBL037W		147208,	150286,	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2)  involved in vesicle mediated transport
chrII	150446	151220	150446	151220	-	YBL036C	YBL036C		150446,	151220,	Putative non-specific single-domain racemase based on structural similarity  binds pyridoxal 5'-phosphate  expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
chrII	151492	153610	151492	153610	-	POL12	YBL035C		151492,	153610,	B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis  also functions in telomere capping and length regulation
chrII	153847	158389	153847	158389	-	STU1	YBL034C		153847,	158389,	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p)  required for interpolar microtubules to provide an outward force on the spindle poles
chrII	158655	159693	158655	159693	-	RIB1	YBL033C		158655,	159693,	GTP cyclohydrolase II  catalyzes the first step of the riboflavin biosynthesis pathway
chrII	160183	161329	160183	161329	+	HEK2	YBL032W		160183,	161329,	RNA binding protein involved in the asymmetric localization of ASH1 mRNA  represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation  regulates telomere position effect and length  similarity to hnRNP-K
chrII	161698	162715	161698	162715	+	SHE1	YBL031W		161698,	162715,	Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p  also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure
chrII	163040	163997	163040	163997	-	PET9	YBL030C		163040,	163997,	Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP  also imports heme and ATP  phosphorylated  required for viability in many lab strains that carry a sal1 mutation
chrII	164487	164772	164487	164772	-	YBL029C-A	YBL029C-A		164487,	164772,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery  has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
chrII	166133	167264	166133	167264	+	YBL029W	YBL029W		166133,	167264,	Non-essential protein of unknown function
chrII	167517	167838	167517	167838	-	YBL028C	YBL028C		167517,	167838,	Protein of unknown function that may interact with ribosomes  green fluorescent protein (GFP)-fusion protein localizes to the nucleolus  predicted to be involved in ribosome biogenesis
chrII	168422	169376	168422	169376	+	RPL19B	YBL027W		168422,168808,	168424,169376,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein  rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
chrII	170622	171038	170622	171038	+	LSM2	YBL026W		170622,170804,	170676,171038,	Lsm (Like Sm) protein  part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay  nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
chrII	171480	171918	171480	171918	+	RRN10	YBL025W		171480,	171918,	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
chrII	172533	174588	172533	174588	+	NCL1	YBL024W		172533,	174588,	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs  similar to Nop2p and human proliferation associated nucleolar protein p120
chrII	174919	177526	174919	177526	-	MCM2	YBL023C		174919,	177526,	Protein involved in DNA replication  component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
chrII	177873	181275	177873	181275	-	PIM1	YBL022C		177873,	181275,	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria  required for biogenesis and maintenance of mitochondria
chrII	181659	182094	181659	182094	-	HAP3	YBL021C		181659,	182094,	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression  contains sequences contributing to both complex assembly and DNA binding
chrII	182400	184125	182400	184125	+	RFT1	YBL020W		182400,	184125,	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase  mutation is suppressed by expression of human p53 protein
chrII	184352	185915	184352	185915	+	APN2	YBL019W		184352,	185915,	Class II abasic (AP) endonuclease involved in repair of DNA damage  homolog of human HAP1 and E. coli exoIII
chrII	185997	186474	185997	186474	-	POP8	YBL018C		185997,186427,	186352,186474,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
chrII	186843	191583	186843	191583	-	PEP1	YBL017C		186843,	191583,	Type I transmembrane sorting receptor for multiple vacuolar hydrolases  cycles between the late-Golgi and prevacuolar endosome-like compartments
chrII	192450	193512	192450	193512	+	FUS3	YBL016W		192450,	193512,	Mitogen-activated serine/threonine protein kinase involved in mating  phosphoactivated by Ste7p  substrates include Ste12p, Far1p, Bni1p, Sst2p  inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
chrII	194121	195702	194121	195702	+	ACH1	YBL015W		194121,	195702,	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate  has minor acetyl-CoA-hydrolase activity  phosphorylated  required for acetate utilization and for diploid pseudohyphal growth
chrII	199063	201748	199063	201748	-	RRN6	YBL014C		199063,	201748,	Component of the core factor (CF) rDNA transcription factor complex  CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
chrII	202055	203261	202055	203261	+	FMT1	YBL013W		202055,	203261,	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria  potential Cdc28p substrate
chrII	203405	203807	203405	203807	-	YBL012C	YBL012C		203405,	203807,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	203537	205817	203537	205817	+	SCT1	YBL011W		203537,	205817,	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
chrII	206106	206949	206106	206949	-	YBL010C	YBL010C		206106,	206949,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
chrII	207193	209224	207193	209224	+	ALK2	YBL009W		207193,	209224,	Protein kinase  accumulation and phosphorylation are periodic during the cell cycle  phosphorylated in response to DNA damage  contains characteristic motifs for degradation via the APC pathway  similar to Alk1p and to mammalian haspins
chrII	209408	209648	209408	209648	+	YBL008W-A	YBL008W-A		209408,	209648,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrII	209652	212175	209652	212175	+	HIR1	YBL008W		209652,	212175,	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription  contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
chrII	212631	216366	212631	216366	-	SLA1	YBL007C		212631,	216366,	Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton  interacts with proteins regulating actin dynamics and proteins required for endocytosis  found in the nucleus and cell cortex  has 3 SH3 domains
chrII	216586	217129	216586	217129	-	LDB7	YBL006C		216586,	217129,	Component of the RSC chromatin remodeling complex  interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
chrII	216710	216860	216710	216860	+	YBL006W-A	YBL006W-A		216710,	216860,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene LDB7/YBL006C
chrII	217469	220400	217469	220400	+	PDR3	YBL005W		217469,	220400,	Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)
chrII	221329	226598	221329	226598	+	YBL005W-B	YBL005W-B		221329,222635,	222634,226598,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrII	221329	222652	221329	222652	+	YBL005W-A	YBL005W-A		221329,	222652,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrII	227635	235117	227635	235117	+	UTP20	YBL004W		227635,	235117,	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
chrII	235393	235792	235393	235792	-	HTA2	YBL003C		235393,	235792,	Histone H2A, core histone protein required for chromatin assembly and chromosome function  one of two nearly identical (see also HTA1) subtypes  DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair  acetylated by Nat4p
chrII	236491	236887	236491	236887	+	HTB2	YBL002W		236491,	236887,	Histone H2B, core histone protein required for chromatin assembly and chromosome function  nearly identical to HTB1  Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
chrII	237152	237467	237152	237467	-	ECM15	YBL001C		237152,	237467,	Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
chrII	238940	241283	238940	241283	-	NTH2	YBR001C		238940,	241283,	Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
chrII	241707	242568	241707	242568	-	RER2	YBR002C		241707,	242568,	Cis-prenyltransferase involved in dolichol synthesis  participates in endoplasmic reticulum (ER) protein sorting
chrII	242808	244230	242808	244230	+	COQ1	YBR003W		242808,	244230,	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
chrII	244365	245667	244365	245667	-	GPI18	YBR004C		244365,	245667,	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis  the authentic, non-tagged protein was localized to mitochondria
chrII	245905	246547	245905	246547	+	RCR1	YBR005W		245905,	246547,	Protein of the ER membrane involved in cell wall chitin deposition  may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane
chrII	247009	248503	247009	248503	+	UGA2	YBR006W		247009,	248503,	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source  part of the 4-aminobutyrate and glutamate degradation pathways  localized to the cytoplasm
chrII	248805	251016	248805	251016	-	DSF2	YBR007C		248805,	251016,	Deletion suppressor of mpt5 mutation
chrII	252562	254209	252562	254209	-	FLR1	YBR008C		252562,	254209,	Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs  expression induced in cells treated with the mycotoxin patulin
chrII	255372	255684	255372	255684	-	HHF1	YBR009C		255372,	255684,	Histone H4, core histone protein required for chromatin assembly and chromosome function  one of two identical histone proteins (see also HHF2)  contributes to telomeric silencing  N-terminal domain involved in maintaining genomic integrity
chrII	256330	256741	256330	256741	+	HHT1	YBR010W		256330,	256741,	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing  one of two identical histone H3 proteins (see HHT2)  regulated by acetylation, methylation, and phosphorylation
chrII	257111	257975	257111	257975	-	IPP1	YBR011C		257111,	257975,	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
chrII	259146	259566	259146	259566	-	YBR012C	YBR012C		259146,	259566,	Dubious open reading frame, unlikely to encode a functional protein  expression induced by iron-regulated transcriptional activator Aft2p
chrII	259868	265140	259868	265140	+	YBR012W-B	YBR012W-B		259868,261174,	261173,265140,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrII	259868	261191	259868	261191	+	YBR012W-A	YBR012W-A		259868,	261191,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrII	265491	265881	265491	265881	-	YBR013C	YBR013C		265491,	265881,	Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein
chrII	266724	267336	266724	267336	-	GRX7	YBR014C		266724,	267336,	Cis-golgi localized monothiol glutaredoxin  more similar in activity to dithiol than other monothiol glutaredoxins  involved in the oxidative stress response  does not bind metal ions  functional overlap with GRX6
chrII	267709	269503	267709	269503	-	MNN2	YBR015C		267709,	269503,	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
chrII	270246	270633	270246	270633	+	YBR016W	YBR016W		270246,	270633,	Tail-anchored plasma membrane protein containing a conserved CYSTM module  predicted to be palmitoylated  has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions
chrII	270946	273703	270946	273703	-	KAP104	YBR017C		270946,	273703,	Transportin or cytosolic karyopherin beta 2  functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p  regulates asymmetric protein synthesis in daughter cells during mitosis
chrII	274426	275527	274426	275527	-	GAL7	YBR018C		274426,	275527,	Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
chrII	276252	278352	276252	278352	-	GAL10	YBR019C		276252,	278352,	UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism  also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
chrII	279020	280607	279020	280607	+	GAL1	YBR020W		279020,	280607,	Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism  expression regulated by Gal4p
chrII	281442	283344	281442	283344	+	FUR4	YBR021W		281442,	283344,	Uracil permease, localized to the plasma membrane  expression is tightly regulated by uracil levels and environmental cues
chrII	283737	284271	283737	284271	+	POA1	YBR022W		283737,	284271,	Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite  may have a role in regulation of tRNA splicing
chrII	284427	287925	284427	287925	-	CHS3	YBR023C		284427,	287925,	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin  required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
chrII	289444	290350	289444	290350	+	SCO2	YBR024W		289444,	290350,	Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase  interacts with Cox2p
chrII	290680	291865	290680	291865	-	OLA1	YBR025C		290680,	291865,	P-loop ATPase with similarity to human OLA1 and bacterial YchF  identified as specifically interacting with the proteasome  protein levels are induced by hydrogen peroxide
chrII	292876	294019	292876	294019	-	ETR1	YBR026C		292876,	294019,	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family  localized to in mitochondria, where it has a probable role in fatty acid synthesis
chrII	294023	294356	294023	294356	-	YBR027C	YBR027C		294023,	294356,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	294424	296002	294424	296002	-	YBR028C	YBR028C		294424,	296002,	An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
chrII	296368	297742	296368	297742	-	CDS1	YBR029C		296368,	297742,	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase)  an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
chrII	298291	299950	298291	299950	+	RKM3	YBR030W		298291,	299950,	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40)  nuclear SET domain containing protein
chrII	300165	301254	300165	301254	+	RPL4A	YBR031W		300165,	301254,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
chrII	301518	301821	301518	301821	+	YBR032W	YBR032W		301518,	301821,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrII	301943	304703	301943	304703	+	EDS1	YBR033W		301943,	304703,	Putative zinc cluster protein  YBR033W is not an essential gene
chrII	304929	305976	304929	305976	-	HMT1	YBR034C		304929,	305976,	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export  methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p
chrII	306268	306955	306268	306955	-	PDX3	YBR035C		306268,	306955,	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus  transcription is under the general control of nitrogen metabolism
chrII	309080	310313	309080	310313	-	CSG2	YBR036C		309080,	310313,	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
chrII	310564	311452	310564	311452	-	SCO1	YBR037C		310564,	311452,	Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration  may function to deliver copper to cytochrome c oxidase  has similarity to thioredoxins
chrII	311897	314789	311897	314789	+	CHS2	YBR038W		311897,	314789,	Chitin synthase II  catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form  required for chitin synthesis in the primary septum during cytokinesis  localization regulated by Cdk1p during mitosis
chrII	315574	316510	315574	316510	+	ATP3	YBR039W		315574,	316510,	Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
chrII	316967	317864	316967	317864	+	FIG1	YBR040W		316967,	317864,	Integral membrane protein required for efficient mating  may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
chrII	318265	320275	318265	320275	+	FAT1	YBR041W		318265,	320275,	Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter  activates imported fatty acids with a preference for very long lengths (C20-C26)  has a separate function in the transport of long chain fatty acids
chrII	320415	321609	320415	321609	-	CST26	YBR042C		320415,	321609,	Protein required for incorporation of stearic acid into phosphatidylinositol  affects chromosome stability when overexpressed
chrII	321875	323945	321875	323945	-	QDR3	YBR043C		321875,	323945,	Multidrug transporter of the major facilitator superfamily, has a role in polyamine homeostasis  expression is upregulated under polyamine stress  required for resistance to quinidine, barban, cisplatin, and bleomycin
chrII	324340	326059	324340	326059	-	TCM62	YBR044C		324340,	326059,	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex  putative chaperone
chrII	328172	330092	328172	330092	-	GIP1	YBR045C		328172,	330092,	Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
chrII	330506	331511	330506	331511	-	ZTA1	YBR046C		330506,	331511,	NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus  has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
chrII	331832	332360	331832	332360	+	FMP23	YBR047W		331832,	332360,	Putative protein of unknown function  proposed to be involved in iron or copper homeostasis  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrII	332830	333812	332830	333812	+	RPS11B	YBR048W		332830,333386,	332875,333812,	Protein component of the small (40S) ribosomal subunit  identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
chrII	334385	336818	334385	336818	-	REB1	YBR049C		334385,	336818,	RNA polymerase I enhancer binding protein  DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II  required for termination of RNA polymerase I transcription
chrII	337182	338199	337182	338199	-	REG2	YBR050C		337182,	338199,	Regulatory subunit of the Glc7p type-1 protein phosphatase  involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
chrII	337987	338338	337987	338338	+	YBR051W	YBR051W		337987,	338338,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
chrII	338719	339352	338719	339352	-	RFS1	YBR052C		338719,	339352,	Protein of unknown function  member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrII	339674	340751	339674	340751	-	YBR053C	YBR053C		339674,	340751,	Putative protein of unknown function  induced by cell wall perturbation
chrII	343100	344135	343100	344135	+	YRO2	YBR054W		343100,	344135,	Protein of unknown function with similarity to archaeal rhodopsins  the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies  transcriptionally regulated by Haa1p
chrII	344601	347301	344601	347301	-	PRP6	YBR055C		344601,	347301,	Splicing factor, component of the U4/U6-U5 snRNP complex
chrII	347878	349384	347878	349384	+	YBR056W	YBR056W		347878,	349384,	Putative cytoplasmic protein of unknown function
chrII	351254	351455	351254	351455	+	YBR056W-A	YBR056W-A		351254,	351455,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YBR056C-B
chrII	351292	351451	351292	351451	-	YBR056C-B	YBR056C-B		351292,	351451,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  almost completely overlaps the dubious ORF YBR056W-A
chrII	352192	353293	352192	353293	-	MUM2	YBR057C		352192,	353293,	Cytoplasmic protein essential for meiotic DNA replication and sporulation  interacts with Orc2p, which is a component of the origin recognition complex
chrII	353671	356017	353671	356017	-	UBP14	YBR058C		353671,	356017,	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains  involved in fructose-1,6-bisphosphatase (Fbp1p) degradation  similar to human isopeptidase T
chrII	356323	356566	356323	356566	-	TSC3	YBR058C-A		356323,	356566,	Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold  involved in sphingolipid biosynthesis
chrII	356860	360187	356860	360187	-	AKL1	YBR059C		356860,	360187,	Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family  involved in endocytosis and actin cytoskeleton organization
chrII	360651	362514	360651	362514	-	ORC2	YBR060C		360651,	362514,	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing  interacts with Spp1p and with trimethylated histone H3  phosphorylated by Cdc28p
chrII	364786	365719	364786	365719	-	TRM7	YBR061C		364786,	365719,	2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
chrII	365975	366600	365975	366600	-	YBR062C	YBR062C		365975,366584,	366502,366600,	Protein of unknown function that interacts with Msb2p  may play a role in activation of the filamentous growth pathway.
chrII	366969	368184	366969	368184	-	YBR063C	YBR063C		366969,	368184,	Putative protein of unknown function  YBR063C is not an essential gene
chrII	367762	368191	367762	368191	+	YBR064W	YBR064W		367762,	368191,	Dubious open reading frame unlikely to encode a protein  partially overlaps the uncharacterized ORF YBR063C
chrII	368583	369678	368583	369678	-	ECM2	YBR065C		368583,	369678,	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
chrII	370036	370699	370036	370699	-	NRG2	YBR066C		370036,	370699,	Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth  has similarity to Nrg1p
chrII	372102	372735	372102	372735	-	TIP1	YBR067C		372102,	372735,	Major cell wall mannoprotein with possible lipase activity  transcription is induced by heat- and cold-shock  member of the Srp1p/Tip1p family of serine-alanine-rich proteins
chrII	373860	375690	373860	375690	-	BAP2	YBR068C		373860,	375690,	High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine  contains 12 predicted transmembrane domains
chrII	376573	378433	376573	378433	-	TAT1	YBR069C		376573,	378433,	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter  overexpression confers FK506 and FTY720 resistance
chrII	379220	379934	379220	379934	-	ALG14	YBR070C		379220,	379934,	Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis  anchors the catalytic subunit Alg13p to the ER membrane  similar to bacterial and human glycosyltransferases
chrII	380410	381046	380410	381046	+	YBR071W	YBR071W		380410,	381046,	Protein of unknown function found in the cytoplasm and bud neck  mRNA expression may be regulated by the cell cycle and/or cell wall stress  overexpression of YBR071W affects endocytic protein trafficking
chrII	382029	382674	382029	382674	+	HSP26	YBR072W		382029,	382674,	Small heat shock protein (sHSP) with chaperone activity  forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation  oligomer activation requires heat-induced conformational change  also has mRNA binding activity
chrII	382859	383021	382859	383021	-	YBR072C-A	YBR072C-A		382859,	383021,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrII	383111	385988	383111	385988	+	RDH54	YBR073W		383111,	385988,	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA  involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis  proposed to be involved in crossover interference
chrII	386285	389216	386285	389216	+	YBR074W	YBR074W		386285,	389216,	Putative metalloprotease
chrII	390226	391291	390226	391291	+	ECM8	YBR076W		390226,	391291,	Non-essential protein of unknown function
chrII	391350	391617	391350	391617	-	YBR076C-A	YBR076C-A		391350,	391617,	Dubious open reading frame unlikely to encode a protein  partially overlaps verified gene ECM8  identified by fungal homology and RT-PCR
chrII	391804	392293	391804	392293	-	SLM4	YBR077C		391804,	392293,	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p  gene exhibits synthetic genetic interaction with MSS4
chrII	393122	394742	393122	394742	+	ECM33	YBR078W		393122,393510,	393180,394742,	GPI-anchored protein of unknown function, has a possible role in apical bud growth  GPI-anchoring on the plasma membrane crucial to function  phosphorylated in mitochondria  similar to Sps2p and Pst1p
chrII	395382	398277	395382	398277	-	RPG1	YBR079C		395382,	398277,	eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation  part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes  involved in translation reinitiation
chrII	398613	400890	398613	400890	-	SEC18	YBR080C		398613,	400890,	ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion  releases Sec17p from SNAP complexes  has similarity to mammalian NSF
chrII	401252	405251	401252	405251	-	SPT7	YBR081C		401252,	405251,	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex  also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
chrII	406627	407169	406627	407169	-	UBC4	YBR082C		406627,407122,	407027,407169,	Ubiquitin-conjugating enzyme (E2), mediates degradation of abnormal or excess proteins, including calmodulin and histone H3  interacts with many SCF ubiquitin protein ligases  component of the cellular stress response
chrII	409168	410629	409168	410629	+	TEC1	YBR083W		409168,	410629,	Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth  TEA/ATTS DNA-binding domain family member
chrII	411053	413981	411053	413981	+	MIS1	YBR084W		411053,	413981,	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF)  provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
chrII	414185	415261	414185	415261	-	RPL19A	YBR084C-A		414185,415259,	414753,415261,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein  rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
chrII	415982	416906	415982	416906	+	AAC3	YBR085W		415982,	416906,	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP  expressed under anaerobic conditions  similar to Pet9p and Aac1p  has roles in maintenance of viability and in respiration
chrII	418906	419164	418906	419164	-	YBR085C-A	YBR085C-A		418906,	419164,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
chrII	420200	423041	420200	423041	-	IST2	YBR086C		420200,	423041,	Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells  mRNA is transported to the bud tip by an actomyosin-driven process
chrII	423764	424829	423764	424829	+	RFC5	YBR087W		423764,	424829,	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
chrII	424989	425766	424989	425766	-	POL30	YBR088C		424989,	425766,	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta  may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
chrII	425182	425782	425182	425782	+	YBR089W	YBR089W		425182,	425782,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  almost completely overlaps the verified gene POL30
chrII	426189	426489	426189	426489	-	NHP6B	YBR089C-A		426189,	426489,	High-mobility group (HMG) protein that binds to and remodels nucleosomes  involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes  functionally redundant with Nhp6Ap  homologous to mammalian HMGB1 and HMGB2
chrII	426332	427058	426332	427058	-	YBR090C	YBR090C		426332,426873,	426516,427058,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
chrII	427154	427484	427154	427484	-	TIM12	YBR091C		427154,	427484,	Essential protein of the inner mitochondrial membrane, peripherally localized  component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
chrII	427697	429101	427697	429101	-	PHO3	YBR092C		427697,	429101,	Constitutively expressed acid phosphatase similar to Pho5p  brought to the cell surface by transport vesicles  hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake  expression is repressed by thiamin
chrII	429547	430951	429547	430951	-	PHO5	YBR093C		429547,	430951,	Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis  secretory pathway derived cell surface glycoprotein  induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
chrII	432035	434297	432035	434297	+	PBY1	YBR094W		432035,	434297,	Putative tubulin tyrosine ligase associated with P-bodies
chrII	434405	435698	434405	435698	-	RXT2	YBR095C		434405,	435698,	Subunit of the histone deacetylase Rpd3L complex  possibly involved in cell fusion and invasive growth
chrII	436020	436713	436020	436713	+	YBR096W	YBR096W		436020,	436713,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the ER
chrII	436950	441315	436950	441315	+	VPS15	YBR097W		436950,	441315,	Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting  functions as a membrane-associated complex with Vps34p  active form recruits Vps34p to the Golgi membrane  interacts with the GDP-bound form of Gpa1p
chrII	441514	443590	441514	443590	+	MMS4	YBR098W		441514,	443590,	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA  involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination
chrII	442923	443307	442923	443307	-	YBR099C	YBR099C		442923,	443307,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene MMS4
chrII	443820	444693	443820	444693	-	FES1	YBR101C		443820,	444693,	Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
chrII	445061	447323	445061	447323	-	EXO84	YBR102C		445061,	447323,	Essential protein with dual roles in spliceosome assembly and exocytosis  the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis
chrII	447708	449316	447708	449316	+	SIF2	YBR103W		447708,	449316,	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes  antagonizes telomeric silencing  binds specifically to the Sir4p N-terminus
chrII	449319	449463	449319	449463	-	YBR103C-A	YBR103C-A		449319,	449463,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  identified by homology to related yeast
chrII	449666	450656	449666	450656	+	YMC2	YBR104W		449666,	450656,	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis  member of the mitochondrial carrier (MCF) family  has similarity with Ymc1p
chrII	450880	451969	450880	451969	-	VID24	YBR105C		450880,	451969,	Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles  regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole  promotes proteasome-dependent catabolite degradation of FBPase
chrII	452657	453224	452657	453224	+	PHO88	YBR106W		452657,	453224,	Probable membrane protein, involved in phosphate transport  pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
chrII	453792	454530	453792	454530	-	IML3	YBR107C		453792,	454530,	Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
chrII	454821	457665	454821	457665	+	AIM3	YBR108W		454821,	457665,	Protein interacting with Rvs167p  null mutant is viable and displays elevated frequency of mitochondrial genome loss
chrII	457918	458362	457918	458362	-	CMD1	YBR109C		457918,	458362,	Calmodulin  Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
chrII	458607	458832	458607	458832	+	YBR109W-A	YBR109W-A		458607,	458832,	Putative protein of unknown function  questionable ORF from MIPS
chrII	458871	460221	458871	460221	+	ALG1	YBR110W		458871,	460221,	Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER)  essential for viability, mutation is functionally complemented by human ortholog
chrII	461177	461873	461177	461873	-	YSA1	YBR111C		461177,	461873,	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity  shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate
chrII	462138	462579	462138	462579	+	SUS1	YBR111W-A		462138,462289,462499,	462209,462429,462579,	Component of both the SAGA histone acetylase and TREX-2 complexes  interacts with RNA polymerase II  involved in mRNA export coupled transcription activation and elongation  involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP
chrII	462869	465770	462869	465770	-	CYC8	YBR112C		462869,	465770,	General transcriptional co-repressor, acts together with Tup1p  also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters  can form the prion [OCT+]
chrII	465565	466048	465565	466048	+	YBR113W	YBR113W		465565,	466048,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene CYC8
chrII	467247	469620	467247	469620	+	RAD16	YBR114W		467247,	469620,	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair  subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
chrII	469747	473926	469747	473926	-	LYS2	YBR115C		469747,	473926,	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine  activation requires posttranslational phosphopantetheinylation by Lys5p
chrII	474198	474726	474198	474726	-	YBR116C	YBR116C		474198,	474726,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene TKL2
chrII	474391	476437	474391	476437	-	TKL2	YBR117C		474391,	476437,	Transketolase, similar to Tkl1p  catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway  needed for synthesis of aromatic amino acids
chrII	477670	479047	477670	479047	+	TEF2	YBR118W		477670,	479047,	Translational elongation factor EF-1 alpha  also encoded by TEF1  functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes  may also have a role in tRNA re-export from the nucleus
chrII	479337	480323	479337	480323	+	MUD1	YBR119W		479337,479434,	479345,480323,	U1 snRNP A protein, homolog of human U1-A  involved in nuclear mRNA splicing
chrII	480434	480923	480434	480923	-	CBP6	YBR120C		480434,	480923,	Mitochondrial protein required for translation of the COB mRNA  forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA  Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
chrII	481363	483367	481363	483367	-	GRS1	YBR121C		481363,	483367,	Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA  transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
chrII	482325	482484	482325	482484	-	YBR121C-A	YBR121C-A		482325,	482484,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely contianed within the verified gene GRS1  identified by expression profiling and mass spectrometry
chrII	483969	484503	483969	484503	-	MRPL36	YBR122C		483969,	484503,	Mitochondrial ribosomal protein of the large subunit  overproduction suppresses mutations in the COX2 leader peptide-encoding region
chrII	484741	486691	484741	486691	-	TFC1	YBR123C		484741,	486691,	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC)  part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes  human homolog is TFIIIC-63
chrII	486506	486866	486506	486866	+	YBR124W	YBR124W		486506,	486866,	Putative protein of unknown function
chrII	487198	488380	487198	488380	-	PTC4	YBR125C		487198,	488380,	Cytoplasmic type 2C protein phosphatase (PP2C)  identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality  overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
chrII	488904	490392	488904	490392	-	TPS1	YBR126C		488904,	490392,	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose  also found in a monomeric form  expression is induced by the stress response and repressed by the Ras-cAMP pathway
chrII	490849	491056	490849	491056	+	YBR126W-A	YBR126W-A		490849,	491056,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YBR126W-B  identified by gene-trapping, microarray analysis, and genome-wide homology searches
chrII	490926	491070	490926	491070	+	YBR126W-B	YBR126W-B		490926,	491070,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YBR126W-A  Identified by SAGE
chrII	491268	492822	491268	492822	-	VMA2	YBR127C		491268,	492822,	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system  contains nucleotide binding sites  also detected in the cytoplasm
chrII	493080	494115	493080	494115	-	ATG14	YBR128C		493080,	494115,	Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p)  Atg14p targets complex I to the phagophore assembly site (PAS)  required for localizing additional ATG proteins to the PAS  homolog of human Barkor
chrII	494352	495339	494352	495339	-	OPY1	YBR129C		494352,	495339,	Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrII	495591	496869	495591	496869	-	SHE3	YBR130C		495591,	496869,	Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex  part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud  also required for cortical ER inheritance
chrII	497162	499277	497162	499277	+	CCZ1	YBR131W		497162,	499277,	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
chrII	497649	497739	497649	497739	-	YBR131C-A	YBR131C-A		497649,	497739,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YBR131W. Identified by gene-trapping, microarray analysis, and genome-wide homology searches
chrII	499651	501442	499651	501442	-	AGP2	YBR132C		499651,	501442,	High affinity polyamine permease, preferentially uses spermidine over putrescine  expression is down-regulated by osmotic stress  plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
chrII	501803	504287	501803	504287	-	HSL7	YBR133C		501803,	504287,	Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation  required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p
chrII	504242	504644	504242	504644	+	YBR134W	YBR134W		504242,	504644,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrII	504853	505306	504853	505306	+	CKS1	YBR135W		504853,	505306,	Cyclin-dependent protein kinase regulatory subunit and adaptor  modulates proteolysis of M-phase targets through interactions with the proteasome  role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
chrII	505667	512774	505667	512774	+	MEC1	YBR136W		505667,	512774,	Genome integrity checkpoint protein and PI kinase superfamily member  signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA  monitors and participates in meiotic recombination
chrII	513043	513583	513043	513583	+	YBR137W	YBR137W		513043,	513583,	Protein of unknown function  localized to the cytoplasm  binds to Replication Protein A (RPA)  also interacts with Sgt2p  YBR137W is not an essential gene
chrII	513761	515336	513761	515336	-	YBR138C	YBR138C		513761,	515336,	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p  YBR138C is not an essential gene
chrII	515663	517190	515663	517190	+	YBR139W	YBR139W		515663,	517190,	Putative serine type carboxypeptidase with a role in phytochelatin synthesis  green fluorescent protein (GFP)-fusion protein localizes to the vacuole  expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
chrII	517349	526628	517349	526628	-	IRA1	YBR140C		517349,	526628,	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase
chrII	527024	528038	527024	528038	-	YBR141C	YBR141C		527024,	528038,	Putative S-adenosylmethionine-dependent methyltransferase  green fluorescent protein (GFP)-fusion protein localizes to the nucleolus  YBR141C is not an essential gene
chrII	527166	527262	527166	527262	+	YBR141W-A	YBR141W-A		527166,	527262,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the uncharacterized ORF YBR141C  identified by gene-trapping, microarray analysis, and genome-wide homology searching
chrII	528316	530638	528316	530638	+	MAK5	YBR142W		528316,	530638,	Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus  involved in biogenesis of large (60S) ribosomal subunits
chrII	530868	532182	530868	532182	-	SUP45	YBR143C		530868,	532182,	Polypeptide release factor (eRF1) in translation termination  mutant form acts as a recessive omnipotent suppressor  methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP  mutation of methylation site confers resistance to zymocin
chrII	533234	533549	533234	533549	-	YBR144C	YBR144C		533234,	533549,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YBR144C is not an essential gene
chrII	533761	534817	533761	534817	+	ADH5	YBR145W		533761,	534817,	Alcohol dehydrogenase isoenzyme V  involved in ethanol production
chrII	535259	536096	535259	536096	+	MRPS9	YBR146W		535259,	536096,	Mitochondrial ribosomal protein of the small subunit
chrII	536574	537465	536574	537465	+	RTC2	YBR147W		536574,	537465,	Protein of unknown function  mutant produces large lipid droplets, is resistant to fluconazole, has decreased levels of rDNA transcription, growth defects on minimal media, and suppresses cdc13-1  detected in highly purified mitochondria  similar to a G-protein coupled receptor from S. pombe
chrII	537875	539705	537875	539705	+	YSW1	YBR148W		537875,	539705,	Protein required for normal prospore membrane formation  interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase  expressed specifically in spores and localizes to the prospore membrane
chrII	539986	541021	539986	541021	+	ARA1	YBR149W		539986,	541021,	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism  purified as homodimer  naturally occurs with a N-terminus degradation product
chrII	541208	544493	541208	544493	-	TBS1	YBR150C		541208,	544493,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrII	545027	545978	545027	545978	+	APD1	YBR151W		545027,	545978,	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide  localizes to both cytoplasm and nucleus
chrII	546375	547251	546375	547251	+	SPP381	YBR152W		546375,	547251,	mRNA splicing factor, component of U4/U6.U5 tri-snRNP  interacts genetically and physically with Prp38p
chrII	547459	548194	547459	548194	+	RIB7	YBR153W		547459,	548194,	Diaminohydroxyphoshoribosylaminopyrimidine deaminase  catalyzes the second step of the riboflavin biosynthesis pathway
chrII	548361	549009	548361	549009	-	RPB5	YBR154C		548361,	549009,	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III  contacts DNA and affects transactivation
chrII	549770	550928	549770	550928	+	CNS1	YBR155W		549770,	550928,	TPR-containing co-chaperone  binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
chrII	551103	553200	551103	553200	-	SLI15	YBR156C		551103,	553200,	Subunit of the conserved chromosomal passenger complex (CPC  Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
chrII	553542	554310	553542	554310	-	ICS2	YBR157C		553542,	554310,	Protein of unknown function  null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
chrII	556548	558198	556548	558198	+	AMN1	YBR158W		556548,	558198,	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability  contains 12 degenerate leucine-rich repeat motifs  expression is induced by the Mitotic Exit Network (MEN)
chrII	558684	559728	558684	559728	+	IFA38	YBR159W		558684,	559728,	Microsomal beta-keto-reductase  contains oleate response element (ORE) sequence in the promoter region  mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
chrII	560077	560974	560077	560974	+	CDC28	YBR160W		560077,	560974,	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK)  alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
chrII	561633	562764	561633	562764	+	CSH1	YBR161W		561633,	562764,	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p  function in sphingolipid biosynthesis is overlapping with that of Sur1p
chrII	563202	564570	563202	564570	-	TOS1	YBR162C		563202,	564570,	Covalently-bound cell wall protein of unknown function  identified as a cell cycle regulated SBF target gene  deletion mutants are highly resistant to treatment with beta-1,3-glucanase  has sequence similarity to YJL171C
chrII	565230	565428	565230	565428	+	YSY6	YBR162W-A		565230,	565428,	Protein whose expression suppresses a secretory pathway mutation in E. coli  has similarity to the mammalian RAMP4 protein involved in secretion
chrII	565722	567480	565722	567480	+	EXO5	YBR163W		565722,	567480,	Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance  distantly related to the RecB nuclease domain of bacterial RecBCD recombinases  may be regulated by the transcription factor Ace2
chrII	567874	568426	567874	568426	-	ARL1	YBR164C		567874,	568426,	Soluble GTPase with a role in regulation of membrane traffic  regulates potassium influx  G protein of the Ras superfamily, similar to ADP-ribosylation factor
chrII	568851	569685	568851	569685	+	UBS1	YBR165W		568851,	569685,	Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity  nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
chrII	569841	571200	569841	571200	-	TYR1	YBR166C		569841,	571200,	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels
chrII	571467	571890	571467	571890	-	POP7	YBR167C		571467,	571890,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
chrII	572370	573612	572370	573612	+	PEX32	YBR168W		572370,	573612,	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size  partially functionally redundant with Pex31p  genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
chrII	573914	575996	573914	575996	-	SSE2	YBR169C		573914,	575996,	Member of the heat shock protein 70 (HSP70) family  may be involved in protein folding  localized to the cytoplasm  highly homologous to the heat shock protein Sse1p
chrII	576343	578086	576343	578086	-	NPL4	YBR170C		576343,	578086,	Ubiquitin-binding protein involved in protein degradation  Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD)
chrII	578363	578984	578363	578984	+	SEC66	YBR171W		578363,	578984,	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)  with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
chrII	579149	581372	579149	581372	-	SMY2	YBR172C		579149,	581372,	Protein of unknown function involved in COPII vesicle formation  interacts with the Sec23p/Sec24p subcomplex  overexpression suppresses the temperature sensitivity of a myo2 mutant  has similarity to S. pombe Mpd2
chrII	581725	582172	581725	582172	-	UMP1	YBR173C		581725,	582172,	Short-lived chaperone required for correct maturation of the 20S proteasome  may inhibit premature dimerization of proteasome half-mers  degraded by proteasome upon completion of its assembly
chrII	582337	582652	582337	582652	-	YBR174C	YBR174C		582337,	582652,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YBR175W  null mutant is viable and sporulation defective
chrII	582407	583355	582407	583355	+	SWD3	YBR175W		582407,	583355,	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres  WD40 beta propeller superfamily member and ortholog of mammalian WDR5
chrII	583719	584658	583719	584658	+	ECM31	YBR176W		583719,	584658,	Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
chrII	584806	586162	584806	586162	-	EHT1	YBR177C		584806,	586162,	Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis  possesses short-chain esterase activity  localizes to lipid particles and the mitochondrial outer membrane
chrII	586070	586445	586070	586445	+	YBR178W	YBR178W		586070,	586445,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YBR177C
chrII	586546	589114	586546	589114	-	FZO1	YBR179C		586546,	589114,	Mitofusin  integral membrane protein involved in mitochondrial outer membrane tethering and fusion  role in mitochondrial genome maintenance  efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain  targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
chrII	589740	591459	589740	591459	+	DTR1	YBR180W		589740,	591459,	Putative dityrosine transporter, required for spore wall synthesis  expressed during sporulation  member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
chrII	591711	592774	591711	592774	-	RPS6B	YBR181C		591711,592768,	592416,592774,	Protein component of the small (40S) ribosomal subunit  identical to Rps6Ap and has similarity to rat S6 ribosomal protein
chrII	593505	594864	593505	594864	-	SMP1	YBR182C		593505,	594864,	Putative transcription factor involved in regulating the response to osmotic stress  member of the MADS-box family of transcription factors
chrII	595360	595555	595360	595555	-	YBR182C-A	YBR182C-A		595360,	595555,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrII	596114	597065	596114	597065	+	YPC1	YBR183W		596114,	597065,	Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide  overexpression confers fumonisin B1 resistance
chrII	597362	598934	597362	598934	+	YBR184W	YBR184W		597362,	598934,	Putative protein of unknown function  YBR184W is not an essential gene
chrII	599122	599959	599122	599959	-	MBA1	YBR185C		599122,	599959,	Membrane-associated mitochondrial ribosome receptor  forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes  possible role in protein export from the matrix to inner membrane
chrII	600552	602360	600552	602360	+	PCH2	YBR186W		600552,602216,	602103,602360,	Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective  also represses meiotic interhomolog recombination in the rDNA
chrII	602633	603476	602633	603476	+	GDT1	YBR187W		602633,	603476,	Putative protein of unknown function  expression is reduced in a gcr1 null mutant  GFP-fusion protein localizes to the vacuole  expression pattern and physical interactions suggest a possible role in ribosome biogenesis
chrII	603684	604107	603684	604107	-	NTC20	YBR188C		603684,	604107,	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
chrII	604507	605508	604507	605508	+	RPS9B	YBR189W		604507,604927,	604514,605508,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
chrII	605965	606277	605965	606277	+	YBR190W	YBR190W		605965,	606277,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
chrII	606269	607140	606269	607140	+	RPL21A	YBR191W		606269,606668,	606280,607140,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
chrII	607148	607223	607148	607223	+	YBR191W-A	YBR191W-A		607148,	607223,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	607651	608785	607651	608785	+	RIM2	YBR192W		607651,	608785,	Mitochondrial pyrimidine nucleotide transporter  imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates  member of the mitochondrial carrier family
chrII	609081	609753	609081	609753	-	MED8	YBR193C		609081,	609753,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation
chrII	610037	610409	610037	610409	+	AIM4	YBR194W		610037,	610409,	Protein proposed to be associated with the nuclear pore complex  null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
chrII	610613	611882	610613	611882	-	MSI1	YBR195C		610613,	611882,	Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase  localizes to the nucleus and cytoplasm  homologous to human retinoblastoma binding proteins RbAp48 and RbAp46
chrII	612235	613900	612235	613900	-	PGI1	YBR196C		612235,	613900,	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate  required for cell cycle progression and completion of the gluconeogenic events of sporulation
chrII	614023	614173	614023	614173	-	YBR196C-A	YBR196C-A		614023,	614173,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrII	614525	614630	614525	614630	-	YBR196C-B	YBR196C-B		614525,	614630,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrII	615202	615856	615202	615856	-	YBR197C	YBR197C		615202,	615856,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YBR197C is not an essential gene
chrII	616126	618523	616126	618523	-	TAF5	YBR198C		616126,	618523,	Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
chrII	618908	620303	618908	620303	+	KTR4	YBR199W		618908,	620303,	Putative mannosyltransferase involved in protein glycosylation  member of the KRE2/MNT1 mannosyltransferase family
chrII	620871	622527	620871	622527	+	BEM1	YBR200W		620871,	622527,	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis  functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
chrII	622982	623147	622982	623147	+	YBR200W-A	YBR200W-A		622982,	623147,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrII	623575	624211	623575	624211	+	DER1	YBR201W		623575,	624211,	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins  N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
chrII	624492	624696	624492	624696	-	YBR201C-A	YBR201C-A		624492,	624696,	Putative protein of unknown function
chrII	625771	628309	625771	628309	+	MCM7	YBR202W		625771,	628309,	Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase  forms an Mcm4p-6p-7p subcomplex
chrII	629167	631942	629167	631942	+	COS111	YBR203W		629167,	631942,	Protein required for resistance to the antifungal drug ciclopirox olamine  not related to the subtelomerically-encoded COS family  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrII	632253	633381	632253	633381	-	YBR204C	YBR204C		632253,	633381,	Serine hydrolase  exhibits active esterase plus weak triacylglycerol lipase activities  proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids  localizes to the lipid droplet (LD) surface  contains a classical serine containing catalytic triad (GxSxG motif)
chrII	633621	634836	633621	634836	+	KTR3	YBR205W		633621,	634836,	Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation  member of the KRE2/MNT1 mannosyltransferase family  Svp26p mediates uptake of Ktr3p into COPII vesicles
chrII	634600	634924	634600	634924	+	YBR206W	YBR206W		634600,	634924,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene KTR3
chrII	635145	636543	635145	636543	+	FTH1	YBR207W		635145,	636543,	Putative high affinity iron transporter involved in transport of intravacuolar stores of iron  forms complex with Fet5p  expression is regulated by iron  proposed to play indirect role in endocytosis
chrII	636702	642210	636702	642210	-	DUR1,2	YBR208C		636702,	642210,	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3  expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
chrII	642582	642900	642582	642900	+	YBR209W	YBR209W		642582,	642900,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YBR209W is not an essential gene
chrII	645549	645978	645549	645978	+	ERV15	YBR210W		645549,	645978,	Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
chrII	646157	647132	646157	647132	-	AME1	YBR211C		646157,	647132,	Essential kinetochore protein associated with microtubules and spindle pole bodies  component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p)  involved in spindle checkpoint maintenance
chrII	647885	649904	647885	649904	+	NGR1	YBR212W		647885,	649904,	RNA binding protein that negatively regulates growth rate  interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation  overexpression impairs mitochondrial function  expressed in stationary phase
chrII	650367	651192	650367	651192	+	MET8	YBR213W		650367,	651192,	Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase  required for sulfate assimilation and methionine biosynthesis
chrII	651414	652998	651414	652998	+	SDS24	YBR214W		651414,	652998,	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation  involved in cell separation during budding  may play an indirect role in fluid-phase endocytosis
chrII	653355	655317	653355	655317	+	HPC2	YBR215W		653355,653452,	653368,655317,	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription  mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
chrII	655575	657600	655575	657600	-	YBP1	YBR216C		655575,	657600,	Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress
chrII	657831	658392	657831	658392	+	ATG12	YBR217W		657831,	658392,	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway  conjugated to Atg5p to form a complex involved in Atg8p lipidation  Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
chrII	658706	662249	658706	662249	-	PYC2	YBR218C		658706,	662249,	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate  highly similar to isoform Pyc1p but differentially regulated  mutations in the human homolog are associated with lactic acidosis
chrII	662498	663303	662498	663303	-	YBR219C	YBR219C		662498,663002,	662581,663303,	Putative protein of unknown function  YBR219C is not an essential gene
chrII	662994	664677	662994	664677	-	YBR220C	YBR220C		662994,	664677,	Putative protein of unknown function  YBR220C is not an essential gene
chrII	665152	666253	665152	666253	-	PDB1	YBR221C		665152,	666253,	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
chrII	666537	666642	666537	666642	+	YBR221W-A	YBR221W-A		666537,	666642,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrII	666719	668351	666719	668351	-	PCS60	YBR222C		666719,	668351,	Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
chrII	668662	670297	668662	670297	-	TDP1	YBR223C		668662,	670297,	Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II  mutations in human homolog result in the neurodegenerative disease SCANI
chrII	668720	668840	668720	668840	+	YBR223W-A	YBR223W-A		668720,	668840,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps YBR223C  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrII	670124	670640	670124	670640	+	YBR224W	YBR224W		670124,	670640,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene TDP1
chrII	670626	673329	670626	673329	+	YBR225W	YBR225W		670626,	673329,	Putative protein of unknown function  non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
chrII	673154	673565	673154	673565	-	YBR226C	YBR226C		673154,	673565,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YBR225W
chrII	673571	675134	673571	675134	-	MCX1	YBR227C		673571,	675134,	Mitochondrial matrix protein  putative ATP-binding chaperone with non-proteolytic function  similar to bacterial ClpX proteins
chrII	675312	676227	675312	676227	+	SLX1	YBR228W		675312,	676227,	Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks  function overlaps with that of Sgs1p-Top3p
chrII	676356	679221	676356	679221	-	ROT2	YBR229C		676356,	679221,	Glucosidase II catalytic subunit required for normal cell wall synthesis  mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
chrII	679548	680050	679548	680050	-	OM14	YBR230C		679548,680039,	679942,680050,	Integral mitochondrial outer membrane protein  abundance is decreased in cells grown in glucose relative to other carbon sources  appears to contain 3 alpha-helical transmembrane segments  ORF encodes a 97-basepair intron
chrII	680361	680562	680361	680562	+	YBR230W-A	YBR230W-A		680361,	680562,	Putative protein of unknown function
chrII	682178	683090	682178	683090	-	SWC5	YBR231C		682178,	683090,	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
chrII	683372	683732	683372	683732	-	YBR232C	YBR232C		683372,	683732,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrII	683427	684669	683427	684669	+	PBP2	YBR233W		683427,	684669,	RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
chrII	684976	685261	684976	685261	+	DAD3	YBR233W-A		684976,	685261,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  is transferred to the kinetochore prior to mitosis
chrII	685437	686592	685437	686592	-	ARC40	YBR234C		685437,	686592,	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
chrII	686900	690263	686900	690263	+	YBR235W	YBR235W		686900,	690263,	Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family  YBR235W is not an essential gene
chrII	690382	691693	690382	691693	-	ABD1	YBR236C		690382,	691693,	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
chrII	691968	694518	691968	694518	+	PRP5	YBR237W		691968,	694518,	RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
chrII	695106	697302	695106	697302	-	YBR238C	YBR238C		695106,	697302,	Mitochondrial membrane protein with similarity to Rmd9p  not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations  transcriptionally up-regulated by TOR  deletion increases life span
chrII	698353	699943	698353	699943	-	ERT1	YBR239C		698353,	699943,	Transcriptional regulator of nonfermentable carbon utilization  GFP-fusion protein localizes to cytoplasm, nucleus  null mutation affects periodicity of transcriptional and metabolic oscillation  plays role in restricting Ty1 transposition
chrII	700489	701842	700489	701842	-	THI2	YBR240C		700489,	701842,	Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
chrII	702588	704055	702588	704055	-	YBR241C	YBR241C		702588,	704055,	Putative transporter, member of the sugar porter family  green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane  YBR241C is not an essential gene
chrII	704669	705386	704669	705386	+	YBR242W	YBR242W		704669,	705386,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YBR242W is not an essential gene
chrII	705446	706793	705446	706793	-	ALG7	YBR243C		705446,	706793,	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation  inhibited by tunicamycin
chrII	707527	708016	707527	708016	+	GPX2	YBR244W		707527,	708016,	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
chrII	708149	711539	708149	711539	-	ISW1	YBR245C		708149,	711539,	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes  ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
chrII	711590	712754	711590	712754	+	RRT2	YBR246W		711590,	712754,	Putative protein of unknown function  non-essential gene identified in a screen for mutants with increased levels of rDNA transcription  null mutants display a weak carboxypeptidase Y missorting/secretion phenotype
chrII	713003	714455	713003	714455	-	ENP1	YBR247C		713003,	714455,	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis  localized in the nucleus and concentrated in the nucleolus
chrII	714806	716465	714806	716465	-	HIS7	YBR248C		714806,	716465,	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
chrII	716881	717994	716881	717994	-	ARO4	YBR249C		716881,	717994,	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
chrII	719032	720604	719032	720604	+	SPO23	YBR250W		719032,	720604,	Protein of unknown function  associates with meiosis-specific protein Spo1p
chrII	721389	722313	721389	722313	+	MRPS5	YBR251W		721389,	722313,	Mitochondrial ribosomal protein of the small subunit
chrII	722610	723054	722610	723054	+	DUT1	YBR252W		722610,	723054,	deoxyuridine triphosphate diphosphatase (dUTPase)  catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication  critical for the maintenance of genetic stability  also has diphosphatase activity on deoxyinosine triphosphate
chrII	723269	723635	723269	723635	+	SRB6	YBR253W		723269,	723635,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation
chrII	723735	724263	723735	724263	-	TRS20	YBR254C		723735,	724263,	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion  mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
chrII	724455	726540	724455	726540	+	MTC4	YBR255W		724455,	726540,	Protein of unknown function, required for normal growth rate at 15 degrees C  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern  mtc4 is synthetically sick with cdc13-1
chrII	726617	727074	726617	727074	-	YBR255C-A	YBR255C-A		726617,727011,	726917,727074,	Putative protein of unknown function  may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase)  identified by sequence comparison with hemiascomycetous yeast species
chrII	727385	728102	727385	728102	-	RIB5	YBR256C		727385,	728102,	Riboflavin synthase  catalyzes the last step of the riboflavin biosynthesis pathway
chrII	728884	729724	728884	729724	+	POP4	YBR257W		728884,	729724,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs  binds to the RPR1 RNA subunit in RNase P
chrII	729733	730162	729733	730162	-	SHG1	YBR258C		729733,	730162,	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
chrII	730386	732453	730386	732453	+	YBR259W	YBR259W		730386,	732453,	Putative protein of unknown function  YBR259W is not an essential gene
chrII	732638	734639	732638	734639	-	RGD1	YBR260C		732638,	734639,	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
chrII	734831	735530	734831	735530	-	TAE1	YBR261C		734831,	735530,	AdoMet-dependent proline methyltransferase  catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues  has a role in protein synthesis  fusion protein localizes to the cytoplasm
chrII	735719	736040	735719	736040	-	AIM5	YBR262C		735719,	736040,	Protein of unknown function  the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies  null mutant displays elevated frequency of mitochondrial genome loss
chrII	736263	737736	736263	737736	+	SHM1	YBR263W		736263,	737736,	Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate  involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis  reverse reaction generates serine
chrII	737769	738369	737769	738369	-	YPT10	YBR264C		737769,	738369,	Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes  may be involved in vesicular transport  overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
chrII	738581	739544	738581	739544	+	TSC10	YBR265W		738581,	739544,	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
chrII	739840	741022	739840	741022	+	REI1	YBR267W		739840,	741022,	Cytoplasmic pre-60S factor  required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis  involved in bud growth in the mitotic signaling network
chrII	739935	740388	739935	740388	-	SLM6	YBR266C		739935,	740388,	Protein with a potential role in actin cytoskeleton organization  gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase
chrII	741298	741616	741298	741616	+	MRPL37	YBR268W		741298,	741616,	Mitochondrial ribosomal protein of the large subunit
chrII	742159	742576	742159	742576	-	FMP21	YBR269C		742159,	742576,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrII	742760	744398	742760	744398	-	BIT2	YBR270C		742760,	744398,	Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity  interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates  similar to Bit61p
chrII	744851	746111	744851	746111	+	YBR271W	YBR271W		744851,	746111,	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  predicted to be involved in ribosome biogenesis
chrII	746360	747803	746360	747803	-	HSM3	YBR272C		746360,	747803,	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP)  involved in DNA mismatch repair during slow growth  weak similarity to Msh1p  related to human 19S subunit S5b
chrII	748060	749371	748060	749371	-	UBX7	YBR273C		748060,	749371,	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
chrII	749593	751177	749593	751177	+	CHK1	YBR274W		749593,	751177,	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p  phosphorylated by checkpoint signal transducer Mec1p  homolog of S. pombe and mammalian Chk1 checkpoint kinase
chrII	751355	757106	751355	757106	-	RIF1	YBR275C		751355,	757106,	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing  deletion results in telomere elongation
chrII	757619	760043	757619	760043	-	PPS1	YBR276C		757619,	760043,	Protein phosphatase with specificity for serine, threonine, and tyrosine residues  has a role in the DNA synthesis phase of the cell cycle
chrII	760214	760616	760214	760616	-	YBR277C	YBR277C		760214,	760616,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YBR278W
chrII	760293	760899	760293	760899	+	DPB3	YBR278W		760293,	760899,	Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing  mRNA abundance peaks at the G1/S boundary of the cell cycle
chrII	761256	762594	761256	762594	+	PAF1	YBR279W		761256,	762594,	Component of the Paf1p complex  binds to and modulates the activity of RNA polymerases I and II  required for expression of a subset of genes, including cell cycle-regulated genes  homolog of human PD2/hPAF1  involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
chrII	762783	764697	762783	764697	-	SAF1	YBR280C		762783,	764697,	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence  interacts with Skp1
chrII	764969	767606	764969	767606	-	DUG2	YBR281C		764969,	767606,	Probable di- and tri-peptidase  forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
chrII	768239	768680	768239	768680	+	MRPL27	YBR282W		768239,	768680,	Mitochondrial ribosomal protein of the large subunit
chrII	768942	770415	768942	770415	-	SSH1	YBR283C		768942,	770415,	Subunit of the Ssh1 translocon complex  Sec61p homolog involved in co-translational pathway of protein translocation  not essential
chrII	771238	773632	771238	773632	+	YBR284W	YBR284W		771238,	773632,	Putative protein of unknown function  YBR284W is not an essential gene  null mutant exhibits decreased resistance to rapamycin and wortmannin and synthetic phenotype with alpha-synuclein
chrII	773921	774356	773921	774356	+	YBR285W	YBR285W		773921,	774356,	Putative protein of unknown function  YBR285W is not an essential gene
chrII	774699	776313	774699	776313	+	APE3	YBR286W		774699,	776313,	Vacuolar aminopeptidase Y, processed to mature form by Prb1p
chrII	776570	777854	776570	777854	+	YBR287W	YBR287W		776570,	777854,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the ER  YBR287W is not an essential gene
chrII	778011	779463	778011	779463	-	APM3	YBR288C		778011,	779463,	Mu3-like subunit of the clathrin associated protein complex (AP-3)  functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
chrII	779666	782384	779666	782384	+	SNF5	YBR289W		779666,	782384,	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation  functions interdependently in transcriptional activation with Snf2p and Snf6p
chrII	782590	783556	782590	783556	+	BSD2	YBR290W		782590,	783556,	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
chrII	783672	784572	783672	784572	-	CTP1	YBR291C		783672,	784572,	Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
chrII	784701	785073	784701	785073	-	YBR292C	YBR292C		784701,	785073,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YBR292C is not an essential gene
chrII	787005	788430	787005	788430	+	VBA2	YBR293W		787005,	788430,	Permease of basic amino acids in the vacuolar membrane
chrII	789234	791814	789234	791814	+	SUL1	YBR294W		789234,	791814,	High affinity sulfate permease of the SulP anion transporter family  sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
chrII	792848	796499	792848	796499	+	PCA1	YBR295W		792848,	796499,	Cadmium transporting P-type ATPase  may also have a role in copper and iron homeostasis  stabilized by Cd binding, which prevents ubiquitination  S288C and other lab strains contain a G970R mutation which eliminates Cd transport function
chrII	796797	798522	796797	798522	-	PHO89	YBR296C		796797,	798522,	Na+/Pi cotransporter, active in early growth phase  similar to phosphate transporters of Neurospora crassa  transcription regulated by inorganic phosphate concentrations and Pho4p
chrII	800122	800242	800122	800242	-	YBR296C-A	YBR296C-A		800122,	800242,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrII	800522	801929	800522	801929	+	MAL33	YBR297W		800522,	801929,	MAL-activator protein, part of complex locus MAL3  nonfunctional in genomic reference strain S288C
chrII	802630	804475	802630	804475	-	MAL31	YBR298C		802630,	804475,	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter)  encoded in the MAL3 complex locus  member of the 12 transmembrane domain superfamily of sugar transporters  functional in genomic reference strain S288C
chrII	805034	805256	805034	805256	-	YBR298C-A	YBR298C-A		805034,	805256,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrII	805350	807105	805350	807105	+	MAL32	YBR299W		805350,	807105,	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism  encoded in the MAL3 complex locus  functional in genomic reference strain S288C  hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
chrII	808599	809097	808599	809097	-	YBR300C	YBR300C		808599,	809097,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YBR301W  YBR300C is not an essential gene
chrII	809056	809419	809056	809419	+	PAU24	YBR301W		809056,	809419,	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p  member of the seripauperin multigene family encoded mainly in subtelomeric regions  expressed under anaerobic conditions, completely repressed during aerobic growth
chrII	810339	811479	810339	811479	-	COS2	YBR302C		810339,	811479,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrIII	1391	2135	1391	2135	+	YCL076W	YCL076W		1391,	2135,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIII	6478	8326	6478	8326	-	YCL073C	YCL073C		6478,	8326,	Proton:glutathione antiporter localized to the vacuolar and plasma membranes  imports glutathione from the vacuole and exports it through the plasma membrane  has a role in resistance to oxidative stress and modulation of the PKA pathway
chrIII	9705	11082	9705	11082	+	VBA3	YCL069W		9705,	11082,	Permease of basic amino acids in the vacuolar membrane
chrIII	11502	12285	11502	12285	-	YCL068C	YCL068C		11502,	12285,	Putative protein of unknown function
chrIII	12385	13018	12385	13018	-	HMLALPHA2	YCL067C		12385,	13018,	Silenced copy of ALPHA2 at HML  homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression
chrIII	13281	13809	13281	13809	+	HMLALPHA1	YCL066W		13281,	13809,	Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression
chrIII	13750	14119	13750	14119	+	YCL065W	YCL065W		13750,	14119,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps HMLALPHA1
chrIII	15797	16880	15797	16880	-	CHA1	YCL064C		15797,	16880,	Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine  required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
chrIII	17289	18561	17289	18561	+	VAC17	YCL063W		17289,	18561,	Phosphoprotein involved in vacuole inheritance  degraded in late M phase of the cell cycle  acts as a vacuole-specific receptor for myosin Myo2p
chrIII	18815	22106	18815	22106	-	MRC1	YCL061C		18815,	22106,	S-phase checkpoint protein required for DNA replication  interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p  protects uncapped telomeres
chrIII	22428	23379	22428	23379	-	KRR1	YCL059C		22428,	23379,	Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
chrIII	23522	23981	23522	23981	-	FYV5	YCL058C		23522,	23981,	Protein involved in regulation of the mating pathway  binds with Matalpha2p to promoters of haploid-specific genes  required for survival upon exposure to K1 killer toxin  involved in ion homeostasis
chrIII	23583	23925	23583	23925	+	ADF1	YCL058W-A		23583,	23925,	Transcriptional repressor encoded by the antisense strand of the FYV5 gene  negatively regulates transcription of FYV5 by binding to the promoter on the sense strand
chrIII	24031	24325	24031	24325	-	YCL057C-A	YCL057C-A		24031,	24325,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIII	24767	26906	24767	26906	+	PRD1	YCL057W		24767,	26906,	Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria  with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins
chrIII	26924	27359	26924	27359	-	YCL056C	YCL056C		26924,	27359,	Peroxisomal integral membrane protein that regulates peroxisome populations  interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation
chrIII	27928	28936	27928	28936	+	KAR4	YCL055W		27928,	28936,	Transcription factor required for gene regulation in response to pheromones  also required during meiosis  exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
chrIII	31448	33974	31448	33974	+	SPB1	YCL054W		31448,	33974,	AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation  methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921  suppressor of PAB1 mutants
chrIII	34142	35393	34142	35393	-	PBN1	YCL052C		34142,	35393,	Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation  homolog of mammalian PIG-X
chrIII	35864	37616	35864	37616	+	LRE1	YCL051W		35864,	37616,	Protein involved in control of cell wall structure and stress response  overproduction confers resistance to cell-wall degrading enzymes  exhibits genetic interactions with genes involved in the cell wall integrity pathway
chrIII	37835	38801	37835	38801	-	APA1	YCL050C		37835,	38801,	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates  has similarity to Apa2p
chrIII	39785	40724	39785	40724	-	YCL049C	YCL049C		39785,	40724,	Protein of unknown function  localizes to membrane fraction  YCL049C is not an essential gene
chrIII	41487	41727	41487	41727	+	YCL048W-A	YCL048W-A		41487,	41727,	Putative protein of unknown function
chrIII	42164	43556	42164	43556	+	SPS22	YCL048W		42164,	43556,	Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
chrIII	43660	44437	43660	44437	-	YCL047C	YCL047C		43660,	44437,	Protein involved in the filamentation pathway  interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion
chrIII	44622	46905	44622	46905	-	EMC1	YCL045C		44622,	46905,	Member of a transmembrane complex required for efficient folding of proteins in the ER  null mutant displays induction of the unfolded protein response  interacts with Gal80p
chrIII	46639	46963	46639	46963	+	YCL046W	YCL046W		46639,	46963,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YCL045C
chrIII	47110	48364	47110	48364	-	MGR1	YCL044C		47110,	48364,	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins  forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis  required for growth of cells lacking mtDNA
chrIII	48652	50221	48652	50221	-	PDI1	YCL043C		48652,	50221,	Protein disulfide isomerase  multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds  forms a complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2 which promotes degradation in the unfolded protein response
chrIII	50132	50627	50132	50627	-	YCL041C	YCL041C		50132,	50627,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
chrIII	50583	50943	50583	50943	+	YCL042W	YCL042W		50583,	50943,	Putative protein of unknown function  epitope-tagged protein localizes to the cytoplasm
chrIII	50837	52340	50837	52340	+	GLK1	YCL040W		50837,	52340,	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism  one of three glucose phosphorylating enzymes  expression regulated by non-fermentable carbon sources
chrIII	52644	54882	52644	54882	+	GID7	YCL039W		52644,	54882,	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase  contains six WD40 repeats  computational analysis suggests that Gid7p and Moh1p have similar functions
chrIII	54940	56527	54940	56527	-	ATG22	YCL038C		54940,	56527,	Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole  null mutation causes a gradual loss of viability during starvation
chrIII	57373	58678	57373	58678	-	SRO9	YCL037C		57373,	58678,	Cytoplasmic RNA-binding protein that associates with translating ribosomes  involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments  contains a La motif
chrIII	59025	60726	59025	60726	+	GFD2	YCL036W		59025,	60726,	Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
chrIII	60840	61173	60840	61173	-	GRX1	YCL035C		60840,	61173,	Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair  protects cells from oxidative damage
chrIII	61657	62722	61657	62722	+	LSB5	YCL034W		61657,	62722,	Protein of unknown function  binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization  may mediate disassembly of the Pan1 complex from the endocytic coat
chrIII	62775	63282	62775	63282	-	MXR2	YCL033C		62775,	63282,	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress  protects iron-sulfur clusters from oxidative inactivation along with MXR1  involved in the regulation of lifespan
chrIII	63440	64481	63440	64481	+	STE50	YCL032W		63440,	64481,	Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
chrIII	64674	65568	64674	65568	-	RRP7	YCL031C		64674,	65568,	Essential protein involved in rRNA processing and ribosome biogenesis
chrIII	65933	68333	65933	68333	-	HIS4	YCL030C		65933,	68333,	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities  catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
chrIII	68598	69921	68598	69921	-	BIK1	YCL029C		68598,	69921,	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation  essential in polyploid cells but not in haploid or diploid cells  ortholog of mammalian CLIP-170
chrIII	70149	71367	70149	71367	+	RNQ1	YCL028W		70149,	71367,	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
chrIII	71802	73341	71802	73341	+	FUS1	YCL027W		71802,	73341,	Membrane protein localized to the shmoo tip, required for cell fusion  expression regulated by mating pheromone  proposed to coordinate signaling, fusion, and polarization events required for fusion  potential Cdc28p substrate
chrIII	73404	73986	73404	73986	-	HBN1	YCL026C-B		73404,	73986,	Putative protein of unknown function  similar to bacterial nitroreductases  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  protein becomes insoluble upon intracellular iron depletion
chrIII	74703	75285	74703	75285	-	FRM2	YCL026C-A		74703,	75285,	Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis  expression induced in cells treated with the mycotoxin patulin  has similarity to bacterial nitroreductases
chrIII	76017	77919	76017	77919	-	AGP1	YCL025C		76017,	77919,	Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids  expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
chrIII	78948	79296	78948	79296	-	YCL023C	YCL023C		78948,	79296,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF KCC4
chrIII	79161	82275	79161	82275	+	KCC4	YCL024W		79161,	82275,	Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
chrIII	81569	82085	81569	82085	-	YCL022C	YCL022C		81569,	82085,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps verified gene KCC4/YCL024W
chrIII	83619	83997	83619	83997	+	YCL021W-A	YCL021W-A		83619,	83997,	Putative protein of unknown function
chrIII	85101	90415	85101	90415	+	YCL019W	YCL019W		85101,86392,	86391,90415,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIII	85101	86418	85101	86418	+	YCL020W	YCL020W		85101,	86418,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIII	91323	92418	91323	92418	+	LEU2	YCL018W		91323,	92418,	Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
chrIII	92776	94270	92776	94270	-	NFS1	YCL017C		92776,	94270,	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs  essential protein located predominantly in mitochondria
chrIII	94620	95763	94620	95763	-	DCC1	YCL016C		94620,	95763,	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
chrIII	96280	101191	96280	101191	+	BUD3	YCL014W		96280,	101191,	Protein involved in bud-site selection and required for axial budding pattern  localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
chrIII	101316	101788	101316	101788	-	YCL012C	YCL012C		101316,101700,	101633,101788,	Putative protein of unknown function  orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii  YCL012C is not an essential gene
chrIII	102074	103358	102074	103358	-	GBP2	YCL011C		102074,	103358,	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm  similar to Hrb1p and Npl3p  also binds single-stranded telomeric repeat sequence in vitro
chrIII	103570	104350	103570	104350	-	SGF29	YCL010C		103570,	104350,	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes  HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p  binds methylated histone H3K4  involved in transcriptional regulation through SAGA recruitment to target promoters and H3 acetylation
chrIII	104618	105548	104618	105548	-	ILV6	YCL009C		104618,	105548,	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis  enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
chrIII	105695	106853	105695	106853	-	STP22	YCL008C		105695,	106853,	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome  homologous to the mouse and human Tsg101 tumor susceptibility gene  mutants exhibit a Class E Vps phenotype
chrIII	106973	107366	106973	107366	-	YCL007C	YCL007C		106973,	107366,	Dubious ORF unlikely to encode a protein  overlaps verified ORF YCL005W-A  mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
chrIII	107022	107417	107022	107417	+	VMA9	YCL005W-A		107022,107110,107287,	107033,107191,107417,	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex  essential for vacuolar acidification  interacts with the V-ATPase assembly factor Vma21p in the ER  involved in V0 biogenesis
chrIII	108020	108791	108020	108791	+	LDB16	YCL005W		108020,	108791,	Protein of unknown function  null mutants have decreased net negative cell surface charge  GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS  native protein is detected in purified mitochondria
chrIII	109104	110670	109104	110670	+	PGS1	YCL004W		109104,	110670,	Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis
chrIII	110807	111675	110807	111675	-	YCL002C	YCL002C		110807,111633,	111557,111675,	Putative protein of unknown function  YCL002C is not an essential gene
chrIII	111915	112482	111915	112482	+	RER1	YCL001W		111915,	112482,	Protein involved in retention of membrane proteins, including Sec12p, in the ER  localized to Golgi  functions as a retrieval receptor in returning membrane proteins to the ER
chrIII	113079	113541	113079	113541	+	YCL001W-A	YCL001W-A		113079,	113541,	Putative protein of unknown function  YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
chrIII	113769	114024	113769	114024	+	YCL001W-B	YCL001W-B		113769,	114024,	Putative protein of unknown function  YCL001W-B gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
chrIII	115684	115999	115684	115999	+	YCR001W	YCR001W		115684,	115999,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YCR001W is not an essential gene
chrIII	117379	118348	117379	118348	-	CDC10	YCR002C		117379,	118348,	Component of the septin ring that is required for cytokinesis  septins recruit proteins to the mother-bud neck and can act as a barrier to diffusion at the membrane, and they comprise the 10 nm filaments seen with EM  required for the transition from a single to double septin ring
chrIII	118619	119171	118619	119171	+	MRPL32	YCR003W		118619,	119171,	Mitochondrial ribosomal protein of the large subunit
chrIII	119574	120318	119574	120318	-	YCP4	YCR004C		119574,	120318,	Protein of unknown function, has sequence and structural similarity to flavodoxins  predicted to be palmitoylated  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIII	120945	122328	120945	122328	-	CIT2	YCR005C		120945,	122328,	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle  expression is controlled by Rtg1p and Rtg2p transcription factors
chrIII	122529	123003	122529	123003	-	YCR006C	YCR006C		122529,	123003,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIII	126010	126730	126010	126730	-	YCR007C	YCR007C		126010,	126730,	Putative integral membrane protein, member of DUP240 gene family  YCR007C is not an essential gene
chrIII	128469	130281	128469	130281	+	SAT4	YCR008W		128469,	130281,	Ser/Thr protein kinase involved in salt tolerance  funtions in regulation of Trk1p-Trk2p potassium transporter  partially redundant with Hal5p  has similarity to Npr1p
chrIII	130744	131542	130744	131542	-	RVS161	YCR009C		130744,	131542,	Amphiphysin-like lipid raft protein  interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
chrIII	132272	133124	132272	133124	-	ADY2	YCR010C		132272,	133124,	Acetate transporter required for normal sporulation  phosphorylated in mitochondria
chrIII	133723	136873	133723	136873	-	ADP1	YCR011C		133723,	136873,	Putative ATP-dependent permease of the ABC transporter family of proteins
chrIII	137745	138996	137745	138996	+	PGK1	YCR012W		137745,	138996,	3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP  key enzyme in glycolysis and gluconeogenesis
chrIII	138401	139049	138401	139049	-	YCR013C	YCR013C		138401,	139049,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
chrIII	139184	140933	139184	140933	-	POL4	YCR014C		139184,	140933,	DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ)  homologous to mammalian DNA polymerase beta
chrIII	141216	142170	141216	142170	-	YCR015C	YCR015C		141216,	142170,	Putative protein of unknown function  YCR015C is not an essential gene
chrIII	143633	144506	143633	144506	+	YCR016W	YCR016W		143633,	144506,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus  predicted to be involved in ribosome biogenesis
chrIII	144772	147634	144772	147634	-	CWH43	YCR017C		144772,	147634,	Putative sensor/transporter protein involved in cell wall biogenesis  contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites  null mutation is synthetically lethal with pkc1 deletion
chrIII	148237	148903	148237	148903	-	SRD1	YCR018C		148237,	148903,	Protein involved in the processing of pre-rRNA to mature rRNA  contains a C2/C2 zinc finger motif  srd1 mutation suppresses defects caused by the rrp1-1 mutation
chrIII	151607	151862	151607	151862	-	YCR018C-A	YCR018C-A		151607,	151862,	Putative protein of unknown function  encoded opposite a Ty1 LTR
chrIII	152836	153928	152836	153928	+	MAK32	YCR019W		152836,	153928,	Protein necessary for structural stability of L-A double-stranded RNA-containing particles
chrIII	154011	154659	154011	154659	-	PET18	YCR020C		154011,	154659,	Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism  expression is induced in the absence of thiamin
chrIII	154829	155096	154829	155096	-	MAK31	YCR020C-A		154829,	155096,	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type  required for replication of dsRNA virus  member of the Sm protein family
chrIII	155319	155556	155319	155556	+	HTL1	YCR020W-B		155319,	155556,	Component of the RSC chromatin remodeling complex  RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion  involved in telomere maintenance
chrIII	156108	157107	156108	157107	-	HSP30	YCR021C		156108,	157107,	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p  induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
chrIII	157420	157765	157420	157765	-	YCR022C	YCR022C		157420,	157765,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YCR022C is not an essential gene
chrIII	158537	160373	158537	160373	-	YCR023C	YCR023C		158537,	160373,	Vacuolar membrane protein of unknown function  member of the multidrug resistance family  YCR023C is not an essential gene
chrIII	160743	162222	160743	162222	-	SLM5	YCR024C		160743,	162222,	Mitochondrial asparaginyl-tRNA synthetase
chrIII	162598	162865	162598	162865	-	YCR024C-B	YCR024C-B		162598,	162865,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrIII	162944	163067	162944	163067	-	PMP1	YCR024C-A		162944,	163067,	Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines
chrIII	163445	163856	163445	163856	-	YCR025C	YCR025C		163445,	163856,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YCR025C is not an essential gene
chrIII	164110	166339	164110	166339	-	NPP1	YCR026C		164110,	166339,	Nucleotide pyrophosphatase/phosphodiesterase family member  mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p  activity and expression enhanced during conditions of phosphate starvation
chrIII	167369	167999	167369	167999	-	RHB1	YCR027C		167369,	167999,	Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake  member of the Ras superfamily of G-proteins
chrIII	170885	172424	170885	172424	-	FEN2	YCR028C		170885,	172424,	Plasma membrane H+-pantothenate symporter  confers sensitivity to the antifungal agent fenpropimorph
chrIII	172949	173440	172949	173440	-	RIM1	YCR028C-A		172949,173198,	173115,173440,	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance  involved in mitochondrial DNA replication
chrIII	173825	176438	173825	176438	-	SYP1	YCR030C		173825,	176438,	Protein of unknown function that is involved in endocytic site formation  may regulate assembly and disassembly of the septin ring  colocalizes and interacts with septin subunits  potential role in actin cytoskeletal organization
chrIII	177499	178220	177499	178220	-	RPS14A	YCR031C		177499,178213,	177906,178220,	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing  mutations confer cryptopleurine resistance  nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
chrIII	179519	186023	179519	186023	+	BPH1	YCR032W		179519,	186023,	PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking  mutant phenotype and genetic interactions suggest a role in protein sorting
chrIII	186488	190169	186488	190169	+	SNT1	YCR033W		186488,	190169,	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p  putative DNA-binding protein  mutant has increased aneuploidy tolerance
chrIII	190591	191635	190591	191635	+	FEN1	YCR034W		190591,	191635,	Fatty acid elongase, involved in sphingolipid biosynthesis  acts on fatty acids of up to 24 carbons in length  mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
chrIII	191833	193018	191833	193018	-	RRP43	YCR035C		191833,	193018,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8)
chrIII	193296	194298	193296	194298	+	RBK1	YCR036W		193296,	194298,	Putative ribokinase
chrIII	194413	197185	194413	197185	-	PHO87	YCR037C		194413,	197185,	Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway  expression is independent of Pi concentration and Pho4p activity  contains 12 membrane-spanning segments
chrIII	197620	199549	197620	199549	-	BUD5	YCR038C		197620,	199549,	GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns  mutants exhibit random budding in all cell types
chrIII	199292	199418	199292	199418	+	YCR038W-A	YCR038W-A		199292,	199418,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene BUD5/YCR038C  identified by homology with hemiascomycetous yeast species
chrIII	199545	200178	199545	200178	-	MATALPHA2	YCR039C		199545,	200178,	Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids  acts with A1p to repress transcription of haploid-specific genes in diploids  one of two genes encoded by the MATalpha mating type cassette
chrIII	200441	200969	200441	200969	+	MATALPHA1	YCR040W		200441,	200969,	Transcriptional co-activator involved in regulation of mating-type-specific gene expression  targets the transcription factor Mcm1p to the promoters of alpha-specific genes  one of two genes encoded by the MATalpha mating type cassette
chrIII	200910	201243	200910	201243	+	YCR041W	YCR041W		200910,	201243,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIII	201173	205397	201173	205397	-	TAF2	YCR042C		201173,	205397,	TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation
chrIII	206260	206644	206260	206644	-	YCR043C	YCR043C		206260,	206644,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus  YCR043C is not an essential gene
chrIII	206876	207950	206876	207950	-	PER1	YCR044C		206876,	207950,	Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts  functionally complemented by human ortholog PERLD1
chrIII	208134	209610	208134	209610	-	RRT12	YCR045C		208134,	209610,	Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls  localizes to the spore wall and also the nuclear envelope and ER region in mature spores
chrIII	208750	209101	208750	209101	+	YCR045W-A	YCR045W-A		208750,	209101,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps with YCR045C  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrIII	209913	210423	209913	210423	-	IMG1	YCR046C		209913,	210423,	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
chrIII	210717	211545	210717	211545	-	BUD23	YCR047C		210717,	211545,	Methyltransferase, methylates residue G1575 of 18S rRNA  required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity  diploid mutant displays random budding pattern
chrIII	211300	211507	211300	211507	+	YCR047W-A	YCR047W-A		211300,	211507,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps with YCR047C  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrIII	211870	212317	211870	212317	-	YCR049C	YCR049C		211870,	212317,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIII	211928	213761	211928	213761	+	ARE1	YCR048W		211928,	213761,	Acyl-CoA:sterol acyltransferase, isozyme of Are2p  endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen
chrIII	213463	213772	213463	213772	-	YCR050C	YCR050C		213463,	213772,	Non-essential protein of unknown function  deletion mutant is synthetically sick or lethal with alpha-synuclein
chrIII	214070	214739	214070	214739	+	YCR051W	YCR051W		214070,	214739,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  contains ankyrin (Ank) repeats  YCR051W is not an essential gene
chrIII	214993	216445	214993	216445	+	RSC6	YCR052W		214993,	216445,	Component of the RSC chromatin remodeling complex  essential for mitotic growth  homolog of SWI/SNF subunit Swp73p
chrIII	216696	218241	216696	218241	+	THR4	YCR053W		216696,	218241,	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine  expression is regulated by the GCN4-mediated general amino acid control pathway
chrIII	218375	220067	218375	220067	-	CTR86	YCR054C		218375,	220067,	Essential protein of unknown function
chrIII	220456	223228	220456	223228	-	PWP2	YCR057C		220456,	223228,	Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites  contains eight WD-repeats  PWP2 deletion leads to defects in cell cycle and bud morphogenesis
chrIII	223453	224230	223453	224230	-	YIH1	YCR059C		223453,	224230,	Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation  has sequence and functional similarity to the mouse IMPACT gene
chrIII	224398	224734	224398	224734	+	TAH1	YCR060W		224398,	224734,	HSP90 cofactor  interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs
chrIII	225562	227458	225562	227458	+	YCR061W	YCR061W		225562,	227458,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrIII	228094	228505	228094	228505	-	YCR064C	YCR064C		228094,	228505,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the verified gene BUD31
chrIII	228317	228791	228317	228791	+	BUD31	YCR063W		228317,	228791,	Component of the SF3b subcomplex of the U2 snRNP  diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
chrIII	229309	231004	229309	231004	+	HCM1	YCR065W		229309,	231004,	Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding  suppressor of calmodulin mutants with specific SPB assembly defects  telomere maintenance role
chrIII	231499	232963	231499	232963	+	RAD18	YCR066W		231499,	232963,	E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164  heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity  required for postreplication repair
chrIII	233124	236322	233124	236322	-	SED4	YCR067C		233124,	236322,	Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity  involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes  binds Sec16p  similar to Sec12p
chrIII	237213	238776	237213	238776	+	ATG15	YCR068W		237213,	238776,	Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies  targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
chrIII	239054	240011	239054	240011	+	CPR4	YCR069W		239054,	240011,	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  has a potential role in the secretory pathway
chrIII	240102	240543	240102	240543	-	IMG2	YCR071C		240102,	240543,	Mitochondrial ribosomal protein of the large subunit
chrIII	240804	242352	240804	242352	-	RSA4	YCR072C		240804,	242352,	WD-repeat protein involved in ribosome biogenesis  may interact with ribosomes  required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
chrIII	242587	246583	242587	246583	-	SSK22	YCR073C		242587,	246583,	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway  functionally redundant with, and homologous to, Ssk2p  interacts with and is activated by Ssk1p  phosphorylates Pbs2p
chrIII	246962	247910	246962	247910	+	SOL2	YCR073W-A		246962,	247910,	Protein with a possible role in tRNA export  shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity  homologous to Sol1p, Sol3p, and Sol4p
chrIII	248032	248815	248032	248815	-	ERS1	YCR075C		248032,	248815,	Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis  contains seven transmembrane domains
chrIII	248974	249202	248974	249202	+	YCR075W-A	YCR075W-A		248974,	249202,	Putative protein of unknown function  identified by homology to Ashbya gossypii
chrIII	249292	250045	249292	250045	-	YCR076C	YCR076C		249292,	250045,	Putative protein of unknown function  YCR076C is not an essential gene
chrIII	250237	252628	250237	252628	-	PAT1	YCR077C		250237,	252628,	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor  also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming  functionally linked to Pab1p
chrIII	252844	254173	252844	254173	+	PTC6	YCR079W		252844,	254173,	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks  involved in mitophagy  null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
chrIII	254370	258654	254370	258654	+	SRB8	YCR081W		254370,	258654,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation  involved in glucose repression
chrIII	258414	258651	258414	258651	-	YCR081C-A	YCR081C-A		258414,	258651,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps with SRB8/YCR081W  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrIII	258882	259269	258882	259269	+	AHC2	YCR082W		258882,	259269,	Component of the ADA histone acetyltransferase complex  Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes  may tether Ach1p to the complex
chrIII	259577	259961	259577	259961	+	TRX3	YCR083W		259577,	259961,	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
chrIII	260310	262452	260310	262452	-	TUP1	YCR084C		260310,	262452,	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
chrIII	262915	263269	262915	263269	+	YCR085W	YCR085W		262915,	263269,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIII	263391	263964	263391	263964	+	CSM1	YCR086W		263391,	263964,	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation  required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
chrIII	263975	264491	263975	264491	+	YCR087W	YCR087W		263975,	264491,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps uncharacterized gene YCR087C-A  YCR087W is not an essential gene
chrIII	264005	264467	264005	264467	-	YCR087C-A	YCR087C-A		264005,	264467,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleolus  YCR087C-A is not an essential gene
chrIII	265067	266846	265067	266846	+	ABP1	YCR088W		265067,	266846,	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
chrIII	267433	272263	267433	272263	+	FIG2	YCR089W		267433,	272263,	Cell wall adhesin, expressed specifically during mating  may be involved in maintenance of cell wall integrity during mating
chrIII	272314	272863	272314	272863	-	YCR090C	YCR090C		272314,	272863,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YCR090C is not an essential gene
chrIII	274403	276566	274403	276566	+	KIN82	YCR091W		274403,	276566,	Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p  similar to Fpk1p
chrIII	276763	279820	276763	279820	-	MSH3	YCR092C		276763,	279820,	Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
chrIII	280116	286443	280116	286443	+	CDC39	YCR093W		280116,	286443,	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation  basal transcription factor
chrIII	286761	287937	286761	287937	+	CDC50	YCR094W		286761,	287937,	Endosomal protein that interacts with phospholipid flippase Drs2p  interaction with Cdc50p is essential for Drs2p catalytic activity  mutations affect cell polarity and polarized growth  similar to Ynr048wp and Lem3p
chrIII	288169	289258	288169	289258	-	OCA4	YCR095C		288169,	289258,	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
chrIII	289638	289797	289638	289797	+	YCR095W-A	YCR095W-A		289638,	289797,	Putative protein of unknown function
chrIII	293178	293538	293178	293538	-	HMRA2	YCR096C		293178,	293538,	Silenced copy of a2 at HMR  similarity to Alpha2p  required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system
chrIII	293834	294321	293834	294321	+	HMRA1	YCR097W		293834,293993,294291,	293939,294239,294321,	Silenced copy of a1 at HMR  homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells
chrIII	294438	294705	294438	294705	+	YCR097W-A	YCR097W-A		294438,	294705,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified by homology to a hemiascomycetous yeast protein
chrIII	297048	298605	297048	298605	-	GIT1	YCR098C		297048,	298605,	Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate  expression and transport rate are regulated by phosphate and inositol availability
chrIII	300831	301299	300831	301299	-	YCR099C	YCR099C		300831,	301299,	Putative protein of unknown function
chrIII	301270	302221	301270	302221	-	YCR100C	YCR100C		301270,	302221,	Putative protein of unknown function
chrIII	302481	303030	302481	303030	-	YCR101C	YCR101C		302481,	303030,	Putative protein of unknown function  localizes to the membrane fraction  YCR101C is not an essential gene
chrIII	304360	305467	304360	305467	-	YCR102C	YCR102C		304360,	305467,	Putative protein of unknown function, involved in copper metabolism  similar to C. carbonum toxD gene  member of the quinone oxidoreductase family
chrIII	306734	306932	306734	306932	+	YCR102W-A	YCR102W-A		306734,	306932,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIII	307800	308175	307800	308175	+	PAU3	YCR104W		307800,	308175,	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
chrIII	309069	310155	309069	310155	+	ADH7	YCR105W		309069,	310155,	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity  member of the cinnamyl family of alcohol dehydrogenases  may be involved in fusel alcohol synthesis or in aldehyde tolerance
chrIII	310957	313456	310957	313456	+	RDS1	YCR106W		310957,	313456,	Zinc cluster transcription factor involved in conferring resistance to cycloheximide
chrIII	313889	314981	313889	314981	+	AAD3	YCR107W		313889,	314981,	Putative aryl-alcohol dehydrogenase  similar to P. chrysosporium aryl-alcohol dehydrogenase  mutational analysis has not yet revealed a physiological role
chrIII	315996	316188	315996	316188	-	YCR108C	YCR108C		315996,	316188,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrIV	1801	2953	1801	2953	+	COS7	YDL248W		1801,	2953,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIV	3761	3836	3761	3836	+	YDL247W-A	YDL247W-A		3761,	3836,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified by sequence comparison with hemiascomycetous yeast species
chrIV	5984	7814	5984	7814	+	MPH2	YDL247W		5984,	7814,	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose  identical to Mph3p  encoded in a subtelomeric position in a region likely to have undergone duplication
chrIV	8682	9756	8682	9756	-	SOR2	YDL246C		8682,	9756,	Protein of unknown function  protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase  computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism
chrIV	11656	13360	11656	13360	-	HXT15	YDL245C		11656,	13360,	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
chrIV	16203	17226	16203	17226	+	THI13	YDL244W		16203,	17226,	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP)  member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
chrIV	17576	18566	17576	18566	-	AAD4	YDL243C		17576,	18566,	Putative aryl-alcohol dehydrogenase  involved in oxidative stress response  similar to P. chrysosporium aryl-alcohol dehydrogenase  expression induced in cells treated with the mycotoxin patulin
chrIV	18958	19312	18958	19312	+	YDL242W	YDL242W		18958,	19312,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	20634	21006	20634	21006	+	YDL241W	YDL241W		20634,	21006,	Putative protein of unknown function  YDL241W is not an essential gene
chrIV	22470	22608	22470	22608	-	YDL240C-A	YDL240C-A		22470,	22608,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified by sequence comparison with hemiascomycetous yeast species
chrIV	22822	25876	22822	25876	+	LRG1	YDL240W		22822,	25876,	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity  appears to specifically regulate 1,3-beta-glucan synthesis
chrIV	26402	28775	26402	28775	-	ADY3	YDL239C		26402,	28775,	Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components  potentially phosphorylated by Cdc28p
chrIV	28984	30454	28984	30454	-	GUD1	YDL238C		28984,	30454,	Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine  activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
chrIV	30656	31829	30656	31829	+	AIM6	YDL237W		30656,	31829,	Putative protein of unknown function, required for respiratory growth  YDL237W is not an essential gene
chrIV	32295	33234	32295	33234	+	PHO13	YDL236W		32295,	33234,	Alkaline phosphatase specific for p-nitrophenyl phosphate  also has protein phosphatase activity
chrIV	33414	33918	33414	33918	-	YPD1	YDL235C		33414,	33918,	Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
chrIV	34236	36477	34236	36477	-	GYP7	YDL234C		34236,	36477,	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro)  involved in vesicle mediated protein trafficking
chrIV	36796	38173	36796	38173	+	YDL233W	YDL233W		36796,	38173,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YDL233W is not an essential gene
chrIV	38486	38597	38486	38597	+	OST4	YDL232W		38486,	38597,	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation  type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex
chrIV	38866	42244	38866	42244	-	BRE4	YDL231C		38866,	42244,	Zinc finger protein containing five transmembrane domains  null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
chrIV	42699	43707	42699	43707	+	PTP1	YDL230W		42699,	43707,	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p  localized to the cytoplasm and the mitochondria  proposed to be a negative regulator of filamentation
chrIV	44064	45906	44064	45906	+	SSB1	YDL229W		44064,	45906,	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p  may be involved in folding of newly-made polypeptide chains  member of the HSP70 family  interacts with phosphatase subunit Reg1p
chrIV	45276	45918	45276	45918	-	YDL228C	YDL228C		45276,	45918,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  almost completely overlaps the verified gene SSB1
chrIV	46270	48031	46270	48031	-	HO	YDL227C		46270,	48031,	Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break  expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
chrIV	51114	52173	51114	52173	-	GCS1	YDL226C		51114,	52173,	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport  shares functional similarity with Glo3p
chrIV	52444	54100	52444	54100	+	SHS1	YDL225W		52444,	54100,	One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
chrIV	54396	56346	54396	56346	-	WHI4	YDL224C		54396,	56346,	Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
chrIV	57264	60405	57264	60405	-	HBT1	YDL223C		57264,	60405,	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection)  mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
chrIV	60871	61801	60871	61801	-	FMP45	YDL222C		60871,	61801,	Integral membrane protein localized to mitochondria (untagged protein)  required for sporulation and maintaining sphingolipid content  has sequence similarity to SUR7 and YNL194C
chrIV	62010	62562	62010	62562	+	YDL221W	YDL221W		62010,	62562,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the 3' end of essential gene CDC13
chrIV	62243	65018	62243	65018	-	CDC13	YDL220C		62243,	65018,	Single stranded DNA-binding protein found at TG1-3 telomere G-tails  regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
chrIV	65241	65765	65241	65765	+	DTD1	YDL219W		65241,65377,	65306,65765,	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery  ubiquitous among eukaryotes
chrIV	66492	67446	66492	67446	+	YDL218W	YDL218W		66492,	67446,	Putative protein of unknown function  YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions  expression also induced in cells treated with the mycotoxin patulin
chrIV	67982	68606	67982	68606	-	TIM22	YDL217C		67982,	68606,	Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane  forms the channel through which proteins are imported
chrIV	68996	70319	68996	70319	-	RRI1	YDL216C		68996,	70319,	Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases  metalloendopeptidase involved in the adaptation to pheromone signaling
chrIV	70639	73918	70639	73918	-	GDH2	YDL215C		70639,	73918,	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate  expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
chrIV	74445	76545	74445	76545	-	PRR2	YDL214C		74445,	76545,	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor  mutant has increased aneuploidy tolerance
chrIV	77288	77966	77288	77966	-	NOP6	YDL213C		77288,	77966,	rRNA-binding protein required for 40S ribosomal subunit biogenesis  contains an RNA recognition motif (RRM) and has similarity to hydrophilins  NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
chrIV	78425	79058	78425	79058	+	SHR3	YDL212W		78425,	79058,	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
chrIV	79293	80412	79293	80412	-	YDL211C	YDL211C		79293,	80412,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole
chrIV	84269	85985	84269	85985	+	UGA4	YDL210W		84269,	85985,	Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source  catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA)  localized to the vacuolar membrane
chrIV	86206	87226	86206	87226	-	CWC2	YDL209C		86206,	87226,	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs  binds directly to U6 snRNA  similar to S. pombe Cwf2
chrIV	87511	87982	87511	87982	+	NHP2	YDL208W		87511,	87982,	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
chrIV	88247	89864	88247	89864	+	GLE1	YDL207W		88247,	89864,	Cytoplasmic nucleoporin required for polyadenylated RNA export  not essential for protein import  contains a nuclear export signal  when bound to inositol hexakisphosphate (IP6), functions as an activator for the ATPase activities of Dbp1p and Dbp5p at the nuclear pore complex during mRNA export
chrIV	90175	92464	90175	92464	+	YDL206W	YDL206W		90175,	92464,	Putative protein of unknown function  YDL206W is not an essential protein
chrIV	92761	93745	92761	93745	-	HEM3	YDL205C		92761,	93745,	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis  localizes to the cytoplasm and nucleus  expression is regulated by Hap2p-Hap3p, but not by levels of heme
chrIV	94604	95786	94604	95786	+	RTN2	YDL204W		94604,	95786,	Protein of unknown function  has similarity to mammalian reticulon proteins  member of the RTNLA (reticulon-like A) subfamily
chrIV	96081	97953	96081	97953	-	ACK1	YDL203C		96081,	97953,	Protein that functions upstream of Pkc1p in the cell wall integrity pathway  GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS  non-tagged Ack1p is detected in purified mitochondria
chrIV	98474	99224	98474	99224	+	MRPL11	YDL202W		98474,	99224,	Mitochondrial ribosomal protein of the large subunit
chrIV	99560	100421	99560	100421	+	TRM8	YDL201W		99560,	100421,	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
chrIV	100500	101067	100500	101067	-	MGT1	YDL200C		100500,	101067,	DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
chrIV	101289	103353	101289	103353	-	YDL199C	YDL199C		101289,	103353,	Putative transporter, member of the sugar porter family
chrIV	103648	104551	103648	104551	-	GGC1	YDL198C		103648,	104551,	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance  has a role in mitochondrial iron transport  member of the mitochondrial carrier family
chrIV	104916	106494	104916	106494	-	ASF2	YDL197C		104916,	106494,	Anti-silencing protein that causes derepression of silent loci when overexpressed
chrIV	106740	107070	106740	107070	+	YDL196W	YDL196W		106740,	107070,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  open reading frame is located in promoter region of essential gene SEC31
chrIV	107207	111029	107207	111029	+	SEC31	YDL195W		107207,	111029,	Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport  mutant has increased aneuploidy tolerance
chrIV	111579	114234	111579	114234	+	SNF3	YDL194W		111579,	114234,	Plasma membrane low glucose sensor that regulates glucose transport  contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters  also senses fructose and mannose  similar to Rgt2p
chrIV	114671	115799	114671	115799	+	NUS1	YDL193W		114671,	115799,	Putative prenyltransferase, required for cell viability  proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
chrIV	116320	116866	116320	116866	+	ARF1	YDL192W		116320,	116866,	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi  functionally interchangeable with Arf2p
chrIV	117663	118517	117663	118517	+	RPL35A	YDL191W		117663,118157,	117666,118517,	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
chrIV	118706	121592	118706	121592	-	UFD2	YDL190C		118706,	121592,	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates  also functions as an E3
chrIV	122215	123589	122215	123589	+	RBS1	YDL189W		122215,	123589,	Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization  proposed to bind single-stranded nucleic acids via its R3H domain
chrIV	123864	124998	123864	124998	-	PPH22	YDL188C		123864,	124998,	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p  methylated at C terminus  forms alternate complexes with several regulatory subunits  involved in signal transduction and regulation of mitosis
chrIV	125508	125838	125508	125838	-	YDL187C	YDL187C		125508,	125838,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	125615	126449	125615	126449	+	YDL186W	YDL186W		125615,	126449,	Putative protein of unknown function  YDL186W is not an essential gene
chrIV	126607	126835	126607	126835	-	YDL185C-A	YDL185C-A		126607,	126835,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YDL185W  identified by homology with hemiascomycetous yeast species
chrIV	126786	130002	126786	130002	+	VMA1	YDL185W		126786,	130002,	Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase  protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
chrIV	130406	130484	130406	130484	-	RPL41A	YDL184C		130406,	130484,	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein  comprised of only 25 amino acids  rpl41a rpl41b double null mutant is viable
chrIV	130870	131833	130870	131833	-	YDL183C	YDL183C		130870,	131833,	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system  non-essential gene
chrIV	133436	134723	133436	134723	+	LYS20	YDL182W		133436,	134723,	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway  highly similar to the other isozyme, Lys21p
chrIV	135178	135436	135178	135436	+	INH1	YDL181W		135178,	135436,	Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase  inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p  has similarity to Stf1p  has a calmodulin-binding motif and binds calmodulin in vitro
chrIV	135895	137539	135895	137539	+	YDL180W	YDL180W		135895,	137539,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole
chrIV	138290	139205	138290	139205	+	PCL9	YDL179W		138290,	139205,	Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
chrIV	139521	141114	139521	141114	+	DLD2	YDL178W		139521,	141114,	D-lactate dehydrogenase, located in the mitochondrial matrix
chrIV	141208	141721	141208	141721	-	YDL177C	YDL177C		141208,	141721,	Putative protein of unknown function  similar to the mouse IMPACT gene  YDL177C is not an essential gene
chrIV	142096	144223	142096	144223	+	YDL176W	YDL176W		142096,	144223,	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation  interacts with components of the GID complex  YDL176W is not an essential gene
chrIV	144483	145518	144483	145518	-	AIR2	YDL175C		144483,	145518,	Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex  stimulates the poly(A) polymerase activity of Pap2p in vitro  functionally redundant with Air1p
chrIV	145825	147589	145825	147589	-	DLD1	YDL174C		145825,	147589,	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate  located in the mitochondrial inner membrane
chrIV	148190	149078	148190	149078	+	PAR32	YDL173W		148190,	149078,	Putative protein of unknown function  hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  PAR32 is not an essential gene
chrIV	148606	149086	148606	149086	-	YDL172C	YDL172C		148606,	149086,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	149202	155640	149202	155640	-	GLT1	YDL171C		149202,	155640,	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate  with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia  expression regulated by nitrogen source
chrIV	156317	157904	156317	157904	+	UGA3	YDL170W		156317,	157904,	Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4)  zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type  localized to the nucleus
chrIV	158063	158735	158063	158735	-	UGX2	YDL169C		158063,	158735,	Protein of unknown function, transcript accumulates in response to any combination of stress conditions
chrIV	159603	160764	159603	160764	+	SFA1	YDL168W		159603,	160764,	Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p
chrIV	160994	163154	160994	163154	-	NRP1	YDL167C		160994,	163154,	Putative RNA binding protein of unknown function  localizes to stress granules induced by glucose deprivation  predicted to be involved in ribosome biogenesis
chrIV	163448	164042	163448	164042	-	FAP7	YDL166C		163448,	164042,	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
chrIV	164289	164865	164289	164865	+	CDC36	YDL165W		164289,	164865,	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation  basal transcription factor
chrIV	164986	167254	164986	167254	-	CDC9	YDL164C		164986,	167254,	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication  also acts in nucleotide excision repair, base excision repair, and recombination
chrIV	166955	167258	166955	167258	+	YDL163W	YDL163W		166955,	167258,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
chrIV	167358	167715	167358	167715	-	YDL162C	YDL162C		167358,	167715,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
chrIV	167713	169078	167713	169078	+	ENT1	YDL161W		167713,	169078,	Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p  binds clathrin via a clathrin-binding domain motif at C-terminus
chrIV	169365	169608	169365	169608	-	YDL160C-A	YDL160C-A		169365,	169608,	Putative protein of unknown function  mutant in a srs2 mutant background displays MMS hypersensitivity  ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability
chrIV	170409	171930	170409	171930	-	DHH1	YDL160C		170409,	171930,	Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
chrIV	172181	172313	172181	172313	+	YDL159W-A	YDL159W-A		172181,	172313,	Putative protein of unknown function  identified by sequence comparison with hemiascomycetous yeast species
chrIV	172480	174028	172480	174028	+	STE7	YDL159W		172480,	174028,	Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p  phosphorylated by Ste11p, degraded by ubiquitin pathway
chrIV	173055	173232	173055	173232	-	YDL159C-B	YDL159C-B		173055,	173232,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrIV	173865	174174	173865	174174	-	YDL158C	YDL158C		173865,	174174,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	174231	174588	174231	174588	-	YDL157C	YDL157C		174231,	174588,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIV	174917	176486	174917	176486	+	YDL156W	YDL156W		174917,	176486,	Putative protein of unknown function  protein sequence contains three WD domains (WD-40 repeat)  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  potential regulatory target of Mbp1p, which binds to the YDL156W promoter region
chrIV	176772	178056	176772	178056	+	CLB3	YDL155W		176772,	178056,	B-type cyclin involved in cell cycle progression  activates Cdc28p to promote the G2/M transition  may be involved in DNA replication and spindle assembly  accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
chrIV	178333	181039	178333	181039	+	MSH5	YDL154W		178333,	181039,	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis  msh5-Y823H mutation confers tolerance to DNA alkylating agents  homologs present in C. elegans and humans
chrIV	181185	183018	181185	183018	-	SAS10	YDL153C		181185,	183018,	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit  disrupts silencing when overproduced  mutant has increased aneuploidy tolerance
chrIV	182821	183187	182821	183187	+	YDL152W	YDL152W		182821,	183187,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
chrIV	183317	183899	183317	183899	-	BUD30	YDL151C		183317,	183899,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  96% of ORF overlaps the verified gene RPC53  diploid mutant displays a weak budding pattern phenotype in a systematic assay
chrIV	183342	184611	183342	184611	+	RPC53	YDL150W		183342,	184611,	RNA polymerase III subunit C53
chrIV	184924	187918	184924	187918	+	ATG9	YDL149W		184924,	187918,	Transmembrane protein involved in forming Cvt and autophagic vesicles  cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes  may be involved in membrane delivery to the PAS
chrIV	188153	190586	188153	190586	-	NOP14	YDL148C		188153,	190586,	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits  also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
chrIV	190923	192261	190923	192261	+	RPN5	YDL147W		190923,	192261,	Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p  Rpn5p is an essential protein
chrIV	192749	194225	192749	194225	+	LDB17	YDL146W		192749,	194225,	Protein involved in the regulation of endocytosis  transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly  GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
chrIV	194570	198176	194570	198176	-	COP1	YDL145C		194570,	198176,	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
chrIV	198661	199732	198661	199732	-	YDL144C	YDL144C		198661,	199732,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YDL144C is not an essential gene.
chrIV	199995	201582	199995	201582	+	CCT4	YDL143W		199995,	201582,	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
chrIV	201718	202570	201718	202570	-	CRD1	YDL142C		201718,	202570,	Cardiolipin synthase  produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function  also required for normal vacuolar ion homeostasis
chrIV	203038	205111	203038	205111	+	BPL1	YDL141W		203038,	205111,	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
chrIV	205359	210561	205359	210561	-	RPO21	YDL140C		205359,	210561,	RNA polymerase II largest subunit B220, part of central core  phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors  similar to bacterial beta-prime
chrIV	211374	212046	211374	212046	-	SCM3	YDL139C		211374,	212046,	Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly  required for G2/M progression and localization of Cse4p  may protect Cse4p from ubiquitylation
chrIV	213350	215642	213350	215642	+	RGT2	YDL138W		213350,	215642,	Plasma membrane high glucose sensor that regulates glucose transport  contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters  highly similar to Snf3p
chrIV	216528	217074	216528	217074	+	ARF2	YDL137W		216528,	217074,	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi  functionally interchangeable with Arf1p
chrIV	217599	218367	217599	218367	+	RPL35B	YDL136W		217599,218007,	217602,218367,	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
chrIV	218679	219288	218679	219288	-	RDI1	YDL135C		218679,	219288,	Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p and Rho1p
chrIV	219661	220771	219661	220771	-	PPH21	YDL134C		219661,	220771,	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p  methylated at C terminus  forms alternate complexes with several regulatory subunits  involved in signal transduction and regulation of mitosis
chrIV	221723	221801	221723	221801	-	RPL41B	YDL133C-A		221723,	221801,	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein  comprised of only 25 amino acids  rpl41a rpl41b double null mutant is viable
chrIV	222426	223740	222426	223740	+	YDL133W	YDL133W		222426,	223740,	Regulator of phospholipase D (Spo14p)  interacts with Spo14p and regulates its catalytic activity  capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
chrIV	224303	226751	224303	226751	+	CDC53	YDL132W		224303,	226751,	Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination  SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
chrIV	227392	228715	227392	228715	+	LYS21	YDL131W		227392,	228715,	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway  highly similar to the other isozyme, Lys20p
chrIV	229170	229431	229170	229431	+	STF1	YDL130W-A		229170,	229431,	Protein involved in regulation of the mitochondrial F1F0-ATP synthase  Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
chrIV	229905	230527	229905	230527	+	RPP1B	YDL130W		229905,230320,	230019,230527,	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome  accumulation is regulated by phosphorylation and interaction with the P2 stalk component
chrIV	231023	231899	231023	231899	+	YDL129W	YDL129W		231023,	231899,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus  YDL129W is not an essential gene
chrIV	232651	233887	232651	233887	+	VCX1	YDL128W		232651,	233887,	Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations  has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
chrIV	234926	235853	234926	235853	+	PCL2	YDL127W		234926,	235853,	Cyclin, interacts with cyclin-dependent kinase Pho85p  member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle  localizes to sites of polarized cell growth
chrIV	236156	238664	236156	238664	-	CDC48	YDL126C		236156,	238664,	ATPase involved in ubiquitin-mediated protein degradation  Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD)  along with Npl4-Ufd1 complex, important for maintaining the cell wall integrity during heat stress to allow G1 progression
chrIV	239018	239606	239018	239606	-	HNT1	YDL125C		239018,239509,	239398,239606,	Adenosine 5'-monophosphoramidase  interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1  member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
chrIV	240258	241197	240258	241197	+	YDL124W	YDL124W		240258,	241197,	NADPH-dependent alpha-keto amide reductase  reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters  member of the aldo-keto reductase (AKR) family
chrIV	241417	241840	241417	241840	+	SNA4	YDL123W		241417,	241840,	Protein of unknown function, localized to the vacuolar outer membrane  predicted to be palmitoylated
chrIV	242551	244981	242551	244981	+	UBP1	YDL122W		242551,	244981,	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins  cleaves at the C terminus of ubiquitin fusions irrespective of their size  capable of cleaving polyubiquitin chains
chrIV	245132	245582	245132	245582	-	YDL121C	YDL121C		245132,	245582,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  YDL121C is not an essential protein
chrIV	245922	246447	245922	246447	+	YFH1	YDL120W		245922,	246447,	Mitochondrial matrix iron chaperone  oxidizes and stores iron  interacts with Isu1p to promote Fe-S cluster assembly  mutation results in multiple Fe/S-dependent enzyme deficiencies  human frataxin homolog is mutated in Friedrich's ataxia
chrIV	246688	247612	246688	247612	-	YDL119C	YDL119C		246688,	247612,	Putative mitochondrial transport protein  GFP-fusion protein is induced in response to the DNA-damaging agent MMS  the authentic, non-tagged protein is detected in purified mitochondria
chrIV	247301	247682	247301	247682	+	YDL118W	YDL118W		247301,	247682,	Non-essential protein of unconfirmed function  mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein
chrIV	248580	251238	248580	251238	+	CYK3	YDL117W		248580,	251238,	SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring  mutant phenotype and genetic interactions suggest a role in cytokinesis
chrIV	251565	253746	251565	253746	+	NUP84	YDL116W		251565,	253746,	Subunit of the nuclear pore complex (NPC)  forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export, and NPC biogenesis  required also for transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
chrIV	253994	255126	253994	255126	-	IWR1	YDL115C		253994,255044,	254974,255126,	RNA polymerase II transport factor, conserved from yeast to humans  involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor  interacts with most of the RNAP II subunits  nucleo-cytoplasmic shuttling protein  deletion causes hypersensitivity to K1 killer toxin
chrIV	254934	255048	254934	255048	+	YDL114W-A	YDL114W-A		254934,	255048,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified based on homology to hemiascomycetous yeasts
chrIV	255603	256530	255603	256530	+	YDL114W	YDL114W		255603,	256530,	Putative protein of unknown function with similarity to acyl-carrier-protein reductases  YDL114W is not an essential gene
chrIV	256632	258555	256632	258555	-	ATG20	YDL113C		256632,	258555,	Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting  has a Phox homology domain that binds phosphatidylinositol-3-phosphate  interacts with Snx4p  potential Cdc28p substrate
chrIV	258914	263225	258914	263225	+	TRM3	YDL112W		258914,	263225,	2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
chrIV	263312	264110	263312	264110	-	RRP42	YDL111C		263312,	264110,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
chrIV	264511	264964	264511	264964	-	TMA17	YDL110C		264511,	264964,	Protein of unknown function that associates with ribosomes  heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background  protein abundance is decreased upon intracellular iron depletion
chrIV	265257	267201	265257	267201	-	YDL109C	YDL109C		265257,	267201,	Putative lipase  involved in lipid metabolism  YDL109C is not an essential gene
chrIV	267697	268699	267697	268699	+	KIN28	YDL108W		267697,267806,	267725,268699,	Serine/threonine protein kinase, subunit of the transcription factor TFIIH  involved in transcription initiation at RNA polymerase II promoters
chrIV	268920	269976	268920	269976	+	MSS2	YDL107W		268920,	269976,	Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
chrIV	270221	271901	270221	271901	-	PHO2	YDL106C		270221,	271901,	Homeobox transcription factor  regulatory targets include genes involved in phosphate metabolism  binds cooperatively with Pho4p to the PHO5 promoter  phosphorylation of Pho2p facilitates interaction with Pho4p
chrIV	272388	273597	272388	273597	+	NSE4	YDL105W		272388,	273597,	Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex
chrIV	273652	274876	273652	274876	-	QRI7	YDL104C		273652,	274876,	Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons  similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification
chrIV	275147	276581	275147	276581	-	QRI1	YDL103C		275147,	276581,	UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis
chrIV	276871	280165	276871	280165	+	POL3	YDL102W		276871,	280165,	Catalytic subunit of DNA polymerase delta  required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
chrIV	280306	281848	280306	281848	-	DUN1	YDL101C		280306,	281848,	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage  also regulates postreplicative DNA repair
chrIV	282111	283176	282111	283176	-	GET3	YDL100C		282111,	283176,	Guanine nucleotide exchange factor for Gpa1p  amplifies G protein signaling  subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane  has low-level ATPase activity
chrIV	283418	284444	283418	284444	+	BUG1	YDL099W		283418,	284444,	Cis-golgi localized protein involved in ER to Golgi transport  forms a complex with the mammalian GRASP65 homolog, Grh1p  mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
chrIV	284580	285165	284580	285165	-	SNU23	YDL098C		284580,	285165,	Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
chrIV	285390	286695	285390	286695	-	RPN6	YDL097C		285390,	286695,	Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome  the human homolog (S9 protein) partially rescues Rpn6p depletion
chrIV	286997	287324	286997	287324	-	OPI6	YDL096C		286997,	287324,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene PMT1/YDL095W  YDL096C is not essential
chrIV	287058	289512	287058	289512	+	PMT1	YDL095W		287058,	289512,	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues  1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity  involved in ER quality control
chrIV	289571	290081	289571	290081	-	YDL094C	YDL094C		289571,	290081,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verfied gene PMT5/YDL093W  YDL094C is not essential
chrIV	289908	292140	289908	292140	+	PMT5	YDL093W		289908,	292140,	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues  acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions  target for new antifungals
chrIV	292780	293221	292780	293221	+	SRP14	YDL092W		292780,	293221,	Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting  homolog of mammalian SRP14
chrIV	293391	294759	293391	294759	-	UBX3	YDL091C		293391,	294759,	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrIV	295033	296329	295033	296329	-	RAM1	YDL090C		295033,	296329,	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins  required for the membrane localization of Ras proteins and a-factor  homolog of the mammalian FTase beta subunit
chrIV	296819	298274	296819	298274	+	NUR1	YDL089W		296819,	298274,	Protein of unknown function  interacts with Csm1p, Lrs4p  required for rDNA repeat stability  null mutant causes increase in unequal sister-chromatid exchange  GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate
chrIV	298416	300003	298416	300003	-	ASM4	YDL088C		298416,	300003,	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
chrIV	300213	300999	300213	300999	-	LUC7	YDL087C		300213,	300999,	Essential protein associated with the U1 snRNP complex  splicing factor involved in recognition of 5' splice site  contains two zinc finger motifs  N-terminal zinc finger binds pre-mRNA
chrIV	301412	302234	301412	302234	+	YDL086W	YDL086W		301412,	302234,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  YDL086W is not an essential gene
chrIV	301654	302089	301654	302089	-	YDL086C-A	YDL086C-A		301654,	302089,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps uncharacterized ORF YDL086W  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrIV	302463	302670	302463	302670	-	YDL085C-A	YDL085C-A		302463,	302670,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
chrIV	303210	304848	303210	304848	+	NDE2	YDL085W		303210,	304848,	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH  Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
chrIV	305236	306577	305236	306577	+	SUB2	YDL084W		305236,	306577,	Component of the TREX complex required for nuclear mRNA export  member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly  homolog of the human splicing factor hUAP56
chrIV	306925	307789	306925	307789	-	RPS16B	YDL083C		306925,307765,	307333,307789,	Protein component of the small (40S) ribosomal subunit  identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
chrIV	308423	309388	308423	309388	+	RPL13A	YDL082W		308423,308792,	308427,309388,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp  not essential for viability  has similarity to rat L13 ribosomal protein
chrIV	309801	310122	309801	310122	-	RPP1A	YDL081C		309801,	310122,	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome  accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
chrIV	310641	312471	310641	312471	-	THI3	YDL080C		310641,	312471,	Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols  required for expression of enzymes involved in thiamine biosynthesis
chrIV	312950	314748	312950	314748	-	MRK1	YDL079C		312950,314336,	314044,314748,	Glycogen synthase kinase 3 (GSK-3) homolog  one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
chrIV	315356	316388	315356	316388	-	MDH3	YDL078C		315356,	316388,	Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate  involved in the glyoxylate cycle
chrIV	316970	320120	316970	320120	-	VAM6	YDL077C		316970,	320120,	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
chrIV	320667	321552	320667	321552	-	RXT3	YDL076C		320667,	321552,	Subunit of the RPD3L complex  involved in histone deacetylation
chrIV	322225	322988	322225	322988	+	RPL31A	YDL075W		322225,322703,	322282,322988,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein  associates with the karyopherin Sxm1p  loss of both Rpl31p and Rpl39p confers lethality
chrIV	324046	326149	324046	326149	-	BRE1	YDL074C		324046,	326149,	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79  required for DSBR, transcription, silencing, and checkpoint control
chrIV	326612	329567	326612	329567	+	YDL073W	YDL073W		326612,	329567,	Putative protein of unknown function  YDL073W is not an essential gene
chrIV	329835	330447	329835	330447	-	YET3	YDL072C		329835,	330447,	Protein of unknown function  YET3 null mutant decreases the level of secreted invertase  homolog of human BAP31 protein
chrIV	330665	331040	330665	331040	-	YDL071C	YDL071C		330665,	331040,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF BDF2/YDL070W
chrIV	331023	332940	331023	332940	+	BDF2	YDL070W		331023,	332940,	Protein involved in transcription initiation at TATA-containing promoters  associates with the basal transcription factor TFIID  contains two bromodomains  corresponds to the C-terminal region of mammalian TAF1  redundant with Bdf1p
chrIV	333120	333810	333120	333810	-	CBS1	YDL069C		333120,	333810,	Mitochondrial translational activator of the COB mRNA  membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
chrIV	333499	333829	333499	333829	+	YDL068W	YDL068W		333499,	333829,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	334216	334396	334216	334396	-	COX9	YDL067C		334216,	334396,	Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
chrIV	334834	336121	334834	336121	+	IDP1	YDL066W		334834,	336121,	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate  not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
chrIV	336248	337277	336248	337277	-	PEX19	YDL065C		336248,	337277,	Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
chrIV	337486	338070	337486	338070	+	UBC9	YDL064W		337486,337634,	337524,338070,	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway  nuclear protein required for S- and M-phase cyclin degradation and mitotic control  involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
chrIV	338271	340134	338271	340134	-	YDL063C	YDL063C		338271,	340134,	Protein required for biogenesis of the large ribosomal subunit  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
chrIV	339856	340282	339856	340282	+	YDL062W	YDL062W		339856,	340282,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps uncharacterized ORF YDL063C  YDL062W is not essential
chrIV	340627	340798	340627	340798	-	RPS29B	YDL061C		340627,	340798,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins
chrIV	341618	343985	341618	343985	+	TSR1	YDL060W		341618,	343985,	Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles
chrIV	344236	344953	344236	344953	-	RAD59	YDL059C		344236,	344953,	Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing  anneals complementary single-stranded DNA  homologous to Rad52p
chrIV	345664	351037	345664	351037	+	USO1	YDL058W		345664,	351037,	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion  binds membranes and functions during vesicle docking to the Golgi  required for assembly of the ER-to-Golgi SNARE complex
chrIV	351433	352420	351433	352420	+	YDL057W	YDL057W		351433,	352420,	Putative protein of unknown function  YDL057W is not an essential gene
chrIV	352876	355378	352876	355378	+	MBP1	YDL056W		352876,	355378,	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
chrIV	355673	356759	355673	356759	-	PSA1	YDL055C		355673,	356759,	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis  required for normal cell wall structure
chrIV	359824	361285	359824	361285	-	MCH1	YDL054C		359824,	361285,	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane  mutant is not deficient in monocarboxylate transport
chrIV	361698	362256	361698	362256	-	PBP4	YDL053C		361698,	362256,	Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system  also interacts with Lsm12p in a copurification assay
chrIV	362671	363583	362671	363583	-	SLC1	YDL052C		362671,	363583,	1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism  enzymatic activity detected in lipid particles and microsomes
chrIV	363951	364779	363951	364779	+	LHP1	YDL051W		363951,	364779,	RNA binding protein required for maturation of tRNA and U6 snRNA precursors  acts as a molecular chaperone for RNAs transcribed by polymerase III  homologous to human La (SS-B) autoantigen
chrIV	364445	364817	364445	364817	-	YDL050C	YDL050C		364445,	364817,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	365067	365874	365067	365874	-	KNH1	YDL049C		365067,	365874,	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis  overproduction suppresses growth defects of a kre9 null mutant  required for propionic acid resistance
chrIV	366738	368211	366738	368211	-	STP4	YDL048C		366738,	368211,	Protein containing a Kruppel-type zinc-finger domain  has similarity to Stp1p, Stp2p, and Stp3p
chrIV	369770	370706	369770	370706	+	SIT4	YDL047W		369770,	370706,	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle  cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
chrIV	371239	371761	371239	371761	+	NPC2	YDL046W		371239,	371761,	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
chrIV	372247	372535	372247	372535	+	MRP10	YDL045W-A		372247,	372535,	Mitochondrial ribosomal protein of the small subunit  contains twin cysteine-x9-cysteine motifs
chrIV	372687	373608	372687	373608	-	FAD1	YDL045C		372687,	373608,	Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
chrIV	373966	375289	373966	375289	-	MTF2	YDL044C		373966,	375289,	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
chrIV	375679	376480	375679	376480	-	PRP11	YDL043C		375679,	376480,	Subunit of the SF3a splicing factor complex, required for spliceosome assembly
chrIV	376756	378445	376756	378445	-	SIR2	YDL042C		376756,	378445,	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan  plays roles in silencing at HML, HMR, telomeres, and the rDNA locus  negatively regulates initiation of DNA replication
chrIV	378101	378455	378101	378455	+	YDL041W	YDL041W		378101,	378455,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene SIR2/YDL042C
chrIV	378873	381438	378873	381438	-	NAT1	YDL040C		378873,	381438,	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p)  N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
chrIV	381984	384081	381984	384081	-	PRM7	YDL039C		381984,	384081,	Pheromone-regulated protein, predicted to have one transmembrane segment  promoter contains Gcn4p binding elements
chrIV	384600	385587	384600	385587	-	BSC1	YDL037C		384600,	385587,	Protein of unconfirmed function, similar to cell surface flocculin Muc1p  ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
chrIV	387512	388901	387512	388901	-	PUS9	YDL036C		387512,	388901,	Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs  contains an N-terminal mitochondrial targeting sequence
chrIV	389171	392057	389171	392057	-	GPR1	YDL035C		389171,	392057,	Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p  sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
chrIV	391782	392127	391782	392127	+	YDL034W	YDL034W		391782,	392127,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps with verified gene GPR1/YDL035C  YDL034W is not an essential gene
chrIV	392658	393912	392658	393912	-	SLM3	YDL033C		392658,	393912,	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs  human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
chrIV	393689	394001	393689	394001	+	YDL032W	YDL032W		393689,	394001,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene SLM3/YDL033C  YDL032W is not an essential gene
chrIV	394216	397204	394216	397204	+	DBP10	YDL031W		394216,	397204,	Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles  essential protein involved in ribosome biogenesis
chrIV	397536	399129	397536	399129	+	PRP9	YDL030W		397536,	399129,	Subunit of the SF3a splicing factor complex, required for spliceosome assembly  acts after the formation of the U1 snRNP-pre-mRNA complex
chrIV	399339	400638	399339	400638	+	ARP2	YDL029W		399339,399484,	399361,400638,	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches  involved in endocytosis and membrane growth and polarity
chrIV	400996	403291	400996	403291	-	MPS1	YDL028C		400996,	403291,	Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function  substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
chrIV	403694	404957	403694	404957	-	YDL027C	YDL027C		403694,	404957,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  YDL027C is not an essential gene
chrIV	404748	405060	404748	405060	+	YDL026W	YDL026W		404748,	405060,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	405343	407206	405343	407206	-	RTK1	YDL025C		405343,	407206,	Putative protein kinase, potentially phosphorylated by Cdc28p  interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1
chrIV	405409	405514	405409	405514	+	YDL025W-A	YDL025W-A		405409,	405514,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the ORF YDL025C  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrIV	408450	409857	408450	409857	-	DIA3	YDL024C		408450,	409857,	Protein of unknown function, involved in invasive and pseudohyphal growth
chrIV	409807	410056	409807	410056	-	YDL022C-A	YDL022C-A		409807,	410056,	Dubious open reading frame unlikely to encode a protein  partially overlaps the verified gene DIA3  identified by fungal homology and RT-PCR
chrIV	411760	412081	411760	412081	-	YDL023C	YDL023C		411760,	412081,	Dubious open reading frame, unlikely to encode a protein  not conserved in other Saccharomyces species  overlaps the verified gene GPD1  deletion confers sensitivity to GSAO  deletion in cyr1 mutant results in loss of stress resistance
chrIV	411824	413000	411824	413000	+	GPD1	YDL022W		411824,	413000,	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress  expression regulated by high-osmolarity glycerol response pathway  homolog of Gpd2p
chrIV	413952	414888	413952	414888	+	GPM2	YDL021W		413952,	414888,	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis  may be non-functional derivative of a gene duplication event
chrIV	415112	416708	415112	416708	-	RPN4	YDL020C		415112,	416708,	Transcription factor that stimulates expression of proteasome genes  Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism  RPN4 is transcriptionally regulated by various stress responses
chrIV	417662	421514	417662	421514	-	OSH2	YDL019C		417662,	421514,	Member of an oxysterol-binding protein family with seven members in S. cerevisiae  family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
chrIV	422832	423510	422832	423510	-	ERP3	YDL018C		422832,	423510,	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
chrIV	424208	425732	424208	425732	+	CDC7	YDL017W		424208,	425732,	DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p  kinase activity correlates with cyclical DBF4 expression
chrIV	425569	425872	425569	425872	-	YDL016C	YDL016C		425569,	425872,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
chrIV	426001	426934	426001	426934	-	TSC13	YDL015C		426001,	426934,	Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
chrIV	427363	428347	427363	428347	+	NOP1	YDL014W		427363,	428347,	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA  has similarity to mammalian fibrillarin
chrIV	429066	430926	429066	430926	+	SLX5	YDL013W		429066,	430926,	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates  contains a RING domain and two SIMs (SUMO-interacting motifs)  forms SUMO-dependent nuclear foci, including DNA repair centers
chrIV	431107	431517	431107	431517	-	YDL012C	YDL012C		431107,431472,	431386,431517,	Tail-anchored plasma membrane protein containing a conserved CYSTM module, possibly involved in response to stress  may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype
chrIV	432307	432631	432307	432631	-	YDL011C	YDL011C		432307,	432631,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the uncharacterized ORF YDL010W
chrIV	432329	433025	432329	433025	+	GRX6	YDL010W		432329,	433025,	Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster  more similar in activity to dithiol than other monothiol glutaredoxins  involved in the oxidative stress response  functional overlap with GRX7
chrIV	432924	433248	432924	433248	-	YDL009C	YDL009C		432924,	433248,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YDL010W  YDL009C is not an essential gene
chrIV	433496	433994	433496	433994	+	APC11	YDL008W		433496,	433994,	Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition  contains a RING-H2 domain that is required for activity
chrIV	436566	436824	436566	436824	-	YDL007C-A	YDL007C-A		436566,	436824,	Putative protein of unknown function
chrIV	438046	439360	438046	439360	+	RPT2	YDL007W		438046,	439360,	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates  required for normal peptide hydrolysis by the core 20S particle
chrIV	439908	440754	439908	440754	+	PTC1	YDL006W		439908,	440754,	Type 2C protein phosphatase (PP2C)  dephosphorylates Hog1p, inactivating osmosensing MAPK cascade  involved in Fus3p activation during pheromone response  deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
chrIV	441013	442309	441013	442309	-	MED2	YDL005C		441013,	442309,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation
chrIV	443028	443511	443028	443511	+	ATP16	YDL004W		443028,	443511,	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis  phosphorylated
chrIV	444682	446383	444682	446383	+	MCD1	YDL003W		444682,	446383,	Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis  apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria  expression peaks in S phase
chrIV	446966	447578	446966	447578	-	NHP10	YDL002C		446966,	447578,	Protein related to mammalian high mobility group proteins  preferentially binds DNA ends, protecting them from exonucleatic cleavage  likely component of the chromatin-remodeling complex INO80 complex  proposed to be involved in DNA repair
chrIV	447983	449276	447983	449276	+	RMD1	YDL001W		447983,	449276,	Cytoplasmic protein required for sporulation
chrIV	450219	452475	450219	452475	-	NTH1	YDR001C		450219,	452475,	Neutral trehalase, degrades trehalose  required for thermotolerance and may mediate resistance to other cellular stresses  may be phosphorylated by Cdc28p
chrIV	453044	453650	453044	453650	+	YRB1	YDR002W		453044,	453650,	Ran GTPase binding protein  involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle  shuttles between the nucleus and cytoplasm  is essential  homolog of human RanBP1
chrIV	454121	454754	454121	454754	+	RCR2	YDR003W		454121,	454754,	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane  similar to Rcr1p
chrIV	454781	454904	454781	454904	+	YDR003W-A	YDR003W-A		454781,	454904,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrIV	455200	456583	455200	456583	+	RAD57	YDR004W		455200,	456583,	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA  involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis  forms heterodimer with Rad55p
chrIV	456835	458103	456835	458103	-	MAF1	YDR005C		456835,458097,	458017,458103,	Negative regulator of RNA polymerase III  component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment  targets the initiation factor TFIIIB
chrIV	458541	461247	458541	461247	-	SOK1	YDR006C		458541,	461247,	Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity  involved in cAMP-mediated signaling  localized to the nucleus  similar to the mouse testis-specific protein PBS13
chrIV	461841	462516	461841	462516	+	TRP1	YDR007W		461841,	462516,	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis  in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
chrIV	462251	462602	462251	462602	-	YDR008C	YDR008C		462251,	462602,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	463433	464996	463433	464996	+	GAL3	YDR009W		463433,	464996,	Transcriptional regulator involved in activation of the GAL genes in response to galactose  forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p  binds galactose and ATP but does not have galactokinase activity
chrIV	465050	465383	465050	465383	-	YDR010C	YDR010C		465050,	465383,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	465918	470424	465918	470424	+	SNQ2	YDR011W		465918,	470424,	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
chrIV	471852	472941	471852	472941	+	RPL4B	YDR012W		471852,	472941,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
chrIV	473156	473783	473156	473783	+	PSF1	YDR013W		473156,	473783,	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
chrIV	474045	475989	474045	475989	+	RAD61	YDR014W		474045,	475989,	Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion  inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p  related to the human Wapl protein that controls the association of cohesin with chromatin
chrIV	477796	478285	477796	478285	+	HED1	YDR014W-A		477796,	478285,	Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired  early meiotic gene, transcribed specifically during meiotic prophase
chrIV	477959	478199	477959	478199	-	YDR015C	YDR015C		477959,	478199,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene HED1/YDR014W-A
chrIV	478473	478758	478473	478758	-	DAD1	YDR016C		478473,	478758,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  is transferred to the kinetochore prior to mitosis
chrIV	479114	482267	479114	482267	-	KCS1	YDR017C		479114,	482267,	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase  generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
chrIV	482669	483860	482669	483860	-	YDR018C	YDR018C		482669,	483860,	Probable membrane protein with three predicted transmembrane domains  homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase
chrIV	484162	485365	484162	485365	-	GCV1	YDR019C		484162,	485365,	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF  expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
chrIV	485745	486444	485745	486444	-	DAS2	YDR020C		485745,	486444,	Putative protein of unknown function  non-essential gene identified in a screen for mutants with increased levels of rDNA transcription  weak similarity with uridine kinases and with phosphoribokinases
chrIV	486803	488003	486803	488003	+	FAL1	YDR021W		486803,	488003,	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
chrIV	488071	488662	488071	488662	-	CIS1	YDR022C		488071,	488662,	Autophagy-specific protein required for autophagosome formation  may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure  high-copy suppressor of CIK1 deletion
chrIV	489507	490896	489507	490896	+	SES1	YDR023W		489507,	490896,	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
chrIV	491016	491502	491016	491502	+	FYV1	YDR024W		491016,	491502,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  mutation decreases survival upon exposure to K1 killer toxin
chrIV	491514	492324	491514	492324	+	RPS11A	YDR025W		491514,491898,	491559,492324,	Protein component of the small (40S) ribosomal subunit  identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
chrIV	492555	494268	492555	494268	-	YDR026C	YDR026C		492555,	494268,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  Myb-like DNA-binding protein that may bind to the Ter region of rDNA  interacts physically with Fob1p
chrIV	494648	497318	494648	497318	-	VPS54	YDR027C		494648,	497318,	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi  potentially phosphorylated by Cdc28p
chrIV	497834	500879	497834	500879	-	REG1	YDR028C		497834,	500879,	Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
chrIV	501099	501414	501099	501414	+	YDR029W	YDR029W		501099,	501414,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
chrIV	501752	503273	501752	503273	-	RAD28	YDR030C		501752,	503273,	Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
chrIV	503497	503863	503497	503863	+	MIC14	YDR031W		503497,	503863,	Mitochondrial intermembrane space protein, required for normal oxygen consumption  contains twin cysteine-x9-cysteine motifs
chrIV	504098	504695	504098	504695	-	PST2	YDR032C		504098,	504695,	Protein with similarity to members of a family of flavodoxin-like proteins  induced by oxidative stress in a Yap1p dependent manner  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIV	508146	509109	508146	509109	+	MRH1	YDR033W		508146,	509109,	Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope  the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state  has similarity to Hsp30p and Yro2p
chrIV	509736	512109	509736	512109	-	LYS14	YDR034C		509736,	512109,	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway  requires 2-aminoadipate semialdehyde as co-inducer
chrIV	514042	519356	514042	519356	-	YDR034C-D	YDR034C-D		514042,518063,	518062,519356,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIV	518039	519356	518039	519356	-	YDR034C-C	YDR034C-C		518039,	519356,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIV	520515	520692	520515	520692	-	YDR034C-A	YDR034C-A		520515,	520692,	Putative protein of unknown function  contained within the solo Ty1 LTR element YDRWdelta7
chrIV	521313	521469	521313	521469	+	YDR034W-B	YDR034W-B		521313,	521469,	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module  related proteins in other organisms may be involved in response to stress  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
chrIV	521815	522928	521815	522928	+	ARO3	YDR035W		521815,	522928,	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
chrIV	523210	524713	523210	524713	-	EHD3	YDR036C		523210,	524713,	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases  non-tagged protein is detected in highly purified mitochondria in high-throughput studies  phosphorylated  mutation affects fluid-phase endocytosis
chrIV	525439	527215	525439	527215	+	KRS1	YDR037W		525439,	527215,	Lysyl-tRNA synthetase
chrIV	527421	530697	527421	530697	-	ENA5	YDR038C		527421,	530697,	Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family
chrIV	531306	534582	531306	534582	-	ENA2	YDR039C		531306,	534582,	P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance  likely not involved in Li+ efflux
chrIV	535191	538467	535191	538467	-	ENA1	YDR040C		535191,	538467,	P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
chrIV	539802	540414	539802	540414	+	RSM10	YDR041W		539802,	540414,	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein  essential for viability, unlike most other mitoribosomal proteins
chrIV	540600	541203	540600	541203	-	YDR042C	YDR042C		540600,	541203,	Putative protein of unknown function  expression is increased in ssu72-ts69 mutant
chrIV	542673	543369	542673	543369	-	NRG1	YDR043C		542673,	543369,	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters  mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
chrIV	546641	547628	546641	547628	+	HEM13	YDR044W		546641,	547628,	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway  transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
chrIV	547977	548310	547977	548310	-	RPC11	YDR045C		547977,	548310,	RNA polymerase III subunit C11  mediates pol III RNA cleavage activity and is important for termination of transcription  homologous to TFIIS
chrIV	548761	550576	548761	550576	-	BAP3	YDR046C		548761,	550576,	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
chrIV	551859	552948	551859	552948	+	HEM12	YDR047W		551859,	552948,	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway  localizes to both the cytoplasm and nucleus  a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
chrIV	553083	553398	553083	553398	-	YDR048C	YDR048C		553083,	553398,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	553253	555152	553253	555152	+	VMS1	YDR049W		553253,	555152,	Component of a Cdc48p-complex involved in protein quality control  exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination  forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD)  conserved in C. elegans and humans
chrIV	555725	556472	555725	556472	-	TPI1	YDR050C		555725,	556472,	Triose phosphate isomerase, abundant glycolytic enzyme  mRNA half-life is regulated by iron availability  transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
chrIV	557055	558060	557055	558060	-	DET1	YDR051C		557055,	558060,	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane  deletion confers sensitivity to nickel
chrIV	558510	560625	558510	560625	-	DBF4	YDR052C		558510,	560625,	Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication  phosphorylates the Mcm2-7 family of proteins  cell cycle regulated
chrIV	560248	560644	560248	560644	+	YDR053W	YDR053W		560248,	560644,	Putative protein of unknown function  open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
chrIV	561439	562327	561439	562327	-	CDC34	YDR054C		561439,	562327,	Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation
chrIV	563526	564861	563526	564861	+	PST1	YDR055W		563526,	564861,	Cell wall protein that contains a putative GPI-attachment site  secreted by regenerating protoplasts  up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p  upregulated by cell wall damage via disruption of FKS1
chrIV	565022	565640	565022	565640	-	YDR056C	YDR056C		565022,	565640,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  YDR056C is not an essential protein
chrIV	565926	567555	565926	567555	+	YOS9	YDR057W		565926,	567555,	ER quality-control lectin  integral subunit of the HRD ligase  binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD  member of the OS-9 protein family
chrIV	567722	568703	567722	568703	-	TGL2	YDR058C		567722,	568703,	Triacylglycerol lipase that is localized to the mitochondria  has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli
chrIV	569233	569770	569233	569770	-	UBC5	YDR059C		569233,569723,	569633,569770,	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3  central component of the cellular stress response  expression is heat inducible
chrIV	570648	573726	570648	573726	+	MAK21	YDR060W		570648,	573726,	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis  involved in nuclear export of pre-ribosomes  required for maintenance of dsRNA virus  homolog of human CAATT-binding protein
chrIV	574163	575783	574163	575783	+	YDR061W	YDR061W		574163,	575783,	Protein with similarity to ATP-binding cassette (ABC) transporter family members  lacks predicted membrane-spanning regions  transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
chrIV	576473	578159	576473	578159	+	LCB2	YDR062W		576473,	578159,	Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
chrIV	578662	579112	578662	579112	+	AIM7	YDR063W		578662,	579112,	Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation  has similarity to Cof1p and also to human glia maturation factor (GMF)  null mutant displays elevated mitochondrial genome loss
chrIV	579457	580452	579457	580452	+	RPS13	YDR064W		579457,580017,	579478,580452,	Protein component of the small (40S) ribosomal subunit  has similarity to E. coli S15 and rat S13 ribosomal proteins
chrIV	580686	581784	580686	581784	+	RRG1	YDR065W		580686,	581784,	Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIV	581907	582498	581907	582498	-	RTR2	YDR066C		581907,	582498,	Protein of unknown function with high similarity to Rtr1p  exhibits genetic interactions with Rtr1p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YDR066C is not an essential gene
chrIV	582790	583465	582790	583465	-	OCA6	YDR067C		582790,	583465,	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication  null mutation confers sensitivity to tunicamycin and DTT
chrIV	583712	584645	583712	584645	+	DOS2	YDR068W		583712,	584645,	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrIV	584938	587719	584938	587719	-	DOA4	YDR069C		584938,	587719,	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
chrIV	588097	588379	588097	588379	-	FMP16	YDR070C		588097,	588379,	Putative protein of unknown function  proposed to be involved in responding to conditions of stress  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIV	588826	589402	588826	589402	-	PAA1	YDR071C		588826,	589402,	Polyamine acetyltransferase  acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine)  may be involved in transcription and/or DNA replication
chrIV	589760	591344	589760	591344	-	IPT1	YDR072C		589760,	591344,	Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid , can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
chrIV	592438	592948	592438	592948	+	SNF11	YDR073W		592438,	592948,	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation  interacts with a highly conserved 40-residue sequence of Snf2p
chrIV	593892	596583	593892	596583	+	TPS2	YDR074W		593892,	596583,	Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose  expression is induced by stress conditions and repressed by the Ras-cAMP pathway
chrIV	597155	598082	597155	598082	+	PPH3	YDR075W		597155,	598082,	Catalytic subunit of protein phosphatase PP4 complex  active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases  regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair  involved in activation of Gln3p to alleviate nitrogen catabolite repression  Pph3p and Psy2p localize to foci on meiotic chromosomes
chrIV	598467	599688	598467	599688	+	RAD55	YDR076W		598467,	599688,	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA  involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis  forms heterodimer with Rad57p
chrIV	600792	601809	600792	601809	+	SED1	YDR077W		600792,	601809,	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance  ORF contains two distinct variable minisatellites
chrIV	602197	602869	602197	602869	-	SHU2	YDR078C		602197,	602869,	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation  associates with Shu1p, Psy3p, and Csm2p
chrIV	603063	603399	603063	603399	+	PET100	YDR079W		603063,	603399,	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane  interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
chrIV	603592	603811	603592	603811	-	TFB5	YDR079C-A		603592,	603811,	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH  involved in transcription initiation and in nucleotide-excision repair  homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
chrIV	604007	606986	604007	606986	+	VPS41	YDR080W		604007,	606986,	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex  essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
chrIV	607303	610081	607303	610081	-	PDC2	YDR081C		607303,	610081,	Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes
chrIV	610440	611925	610440	611925	+	STN1	YDR082W		610440,	611925,	Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
chrIV	612072	613251	612072	613251	+	RRP8	YDR083W		612072,	613251,	Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2  also involved in telomere maintenance  mutation is synthetically lethal with a gar1 mutation
chrIV	613404	614004	613404	614004	-	TVP23	YDR084C		613404,	614004,	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrIV	614287	616150	614287	616150	-	AFR1	YDR085C		614287,	616150,	Protein required for pheromone-induced projection (shmoo) formation  regulates septin architecture during mating  has an RVXF motif that mediates targeting of Glc7p to mating projections  interacts with Cdc12p
chrIV	616927	617170	616927	617170	-	SSS1	YDR086C		616927,	617170,	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p)  interacts with Ost4p and Wbp1p
chrIV	617469	618306	617469	618306	-	RRP1	YDR087C		617469,	618306,	Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
chrIV	618496	619645	618496	619645	-	SLU7	YDR088C		618496,	619645,	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing  interacts with Prp18p  contains zinc knuckle domain
chrIV	622111	624721	622111	624721	+	YDR089W	YDR089W		622111,	624721,	Protein of unknown function  deletion confers resistance to Nickel
chrIV	625065	625998	625065	625998	-	YDR090C	YDR090C		625065,	625998,	Putative protein of unknown function
chrIV	626707	628534	626707	628534	-	RLI1	YDR091C		626707,	628534,	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination  facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit  predicted ABC family ATPase
chrIV	629875	630605	629875	630605	+	UBC13	YDR092W		629875,630173,	629905,630605,	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway  interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue  DNA damage triggers redistribution from the cytoplasm to the nucleus
chrIV	631281	636120	631281	636120	+	DNF2	YDR093W		631281,	636120,	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane  contributes to endocytosis, protein transport and cell polarity  type 4 P-type ATPase
chrIV	635839	636175	635839	636175	+	YDR094W	YDR094W		635839,	636175,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF DNF2
chrIV	636116	636527	636116	636527	-	YDR095C	YDR095C		636116,	636527,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	637138	639823	637138	639823	+	GIS1	YDR096W		637138,	639823,	JmjC domain-containing histone demethylase and transcription factor  involved in expression of genes during nutrient limitation  negatively regulates DPP1 and PHR1  activity is modulated by limited proteasome-mediated proteolysis  has a JmjC and a JmjN domain in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity  contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain
chrIV	640108	643837	640108	643837	-	MSH6	YDR097C		640108,	643837,	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs  potentially phosphorylated by Cdc28p
chrIV	644177	645035	644177	645035	-	GRX3	YDR098C		644177,	645035,	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase  monothiol glutaredoxin subfamily member along with Grx4p and Grx5p  protects cells from oxidative damage
chrIV	645857	651126	645857	651126	-	YDR098C-B	YDR098C-B		645857,649821,	649820,651126,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIV	649803	651126	649803	651126	-	YDR098C-A	YDR098C-A		649803,	651126,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIV	653606	654428	653606	654428	+	BMH2	YDR099W		653606,	654428,	14-3-3 protein, minor isoform  controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
chrIV	655012	655444	655012	655444	+	TVP15	YDR100W		655012,	655444,	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
chrIV	655685	657467	655685	657467	-	ARX1	YDR101C		655685,	657467,	Shuttling pre-60S factor  involved in the biogenesis of ribosomal large subunit biogenesis  interacts directly with Alb1  responsible for Tif6 recycling defects in absence of Rei1  associated with the ribosomal export complex
chrIV	657647	657980	657647	657980	-	YDR102C	YDR102C		657647,	657980,	Dubious open reading frame  homozygous diploid deletion strain exhibits high budding index
chrIV	658349	661103	658349	661103	+	STE5	YDR103W		658349,	661103,	Pheromone-response scaffold protein that controls the mating decision  binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p  allosteric activator of Fus3p
chrIV	661172	664910	661172	664910	-	SPO71	YDR104C		661172,	664910,	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation  dispensable for both nuclear divisions during meiosis
chrIV	665348	666770	665348	666770	-	TMS1	YDR105C		665348,	666770,	Vacuolar membrane protein of unknown function that is conserved in mammals  predicted to contain eleven transmembrane helices  interacts with Pdr5p, a protein involved in multidrug resistance
chrIV	667003	667858	667003	667858	+	ARP10	YDR106W		667003,	667858,	Component of the dynactin complex, localized to the pointed end of the Arp1p filament  may regulate membrane association of the complex
chrIV	669015	671034	669015	671034	-	TMN2	YDR107C		669015,	671034,	Protein with a role in cellular adhesion and filamentous growth  similar to Emp70p and Tmn3p  member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
chrIV	671268	673365	671268	673365	+	GSG1	YDR108W		671268,	673365,	Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway  directs Ypt1p to the PAS  late post-replication meiotic role
chrIV	673519	675667	673519	675667	-	YDR109C	YDR109C		673519,	675667,	Putative kinase
chrIV	676101	677802	676101	677802	+	FOB1	YDR110W		676101,	677802,	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site  required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation  related to retroviral integrases
chrIV	678240	679764	678240	679764	-	ALT2	YDR111C		678240,	679764,	Putative alanine transaminase (glutamic pyruvic transaminase)
chrIV	679543	679852	679543	679852	+	IRC2	YDR112W		679543,	679852,	Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps YDR111C  null mutant displays increased levels of spontaneous Rad52p foci
chrIV	680495	681617	680495	681617	-	PDS1	YDR113C		680495,	681617,	Securin, inhibits anaphase by binding separin Esp1p  blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest  localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
chrIV	681923	682226	681923	682226	-	YDR114C	YDR114C		681923,	682226,	Putative protein of unknown function  deletion mutant exhibits poor growth at elevated pH and calcium
chrIV	682174	682492	682174	682492	+	YDR115W	YDR115W		682174,	682492,	Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein  required for respiratory growth, as are most mitochondrial ribosomal proteins
chrIV	682723	683581	682723	683581	-	MRPL1	YDR116C		682723,	683581,	Mitochondrial ribosomal protein of the large subunit
chrIV	683945	685643	683945	685643	-	TMA64	YDR117C		683945,	685643,	Protein of unknown function that associates with ribosomes  has a putative RNA binding domain  in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
chrIV	685881	687840	685881	687840	+	APC4	YDR118W		685881,	687840,	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition  component of the platform domain of the APC/C, based on structural analysis
chrIV	687767	687884	687767	687884	+	YDR118W-A	YDR118W-A		687767,	687884,	Dubious open reading frame  identified using a combination of expression profiling and mass spectrometry
chrIV	688226	690533	688226	690533	+	VBA4	YDR119W		688226,	690533,	Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny  GFP-fusion protein localizes to vacuolar membrane  physical interaction with Atg27p suggests a possible role in autophagy  non-essential gene
chrIV	691013	691214	691013	691214	+	YDR119W-A	YDR119W-A		691013,	691214,	Putative protein of unknown function  may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase)
chrIV	691548	693261	691548	693261	-	TRM1	YDR120C		691548,	693261,	tRNA methyltransferase  two forms of the protein are made by alternative translation starts  localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
chrIV	693584	694175	693584	694175	+	DPB4	YDR121W		693584,	694175,	Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex  involved in both chromosomal DNA replication and in inheritance of telomeric silencing
chrIV	694699	697894	694699	697894	+	KIN1	YDR122W		694699,	697894,	Serine/threonine protein kinase involved in regulation of exocytosis  localizes to the cytoplasmic face of the plasma membrane  closely related to Kin2p
chrIV	698553	699468	698553	699468	-	INO2	YDR123C		698553,	699468,	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
chrIV	700314	701289	700314	701289	+	YDR124W	YDR124W		700314,	701289,	Putative protein of unknown function  non-essential gene  expression is strongly induced by alpha factor
chrIV	701396	702758	701396	702758	-	ECM18	YDR125C		701396,	702758,	Protein of unknown function, similar to Rlp24p
chrIV	703233	704244	703233	704244	+	SWF1	YDR126W		703233,	704244,	Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs  contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain  may have a role in vacuole fusion
chrIV	704483	709250	704483	709250	+	ARO1	YDR127W		704483,	709250,	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
chrIV	709548	712995	709548	712995	+	MTC5	YDR128W		709548,	712995,	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole  has N-terminal WD-40 repeats and a C-terminal RING motif  mtc5 is synthetically sick with cdc13-1
chrIV	713339	715379	713339	715379	-	SAC6	YDR129C		713339,715358,	715247,715379,	Fimbrin, actin-bundling protein  cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
chrIV	715746	716622	715746	716622	-	FIN1	YDR130C		715746,	716622,	Spindle pole body-related intermediate filament protein  forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells  localization cell-cycle dependent  involved in Glc7p localization and regulation
chrIV	716789	718460	716789	718460	-	YDR131C	YDR131C		716789,	718460,	F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
chrIV	718815	720303	718815	720303	-	YDR132C	YDR132C		718815,	720303,	Putative protein of unknown function
chrIV	720961	721297	720961	721297	-	YDR133C	YDR133C		720961,	721297,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps YDR134C
chrIV	723003	727551	723003	727551	-	YCF1	YDR135C		723003,	727551,	Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite  also transports unconjugated bilirubin  similar to human cystic fibrosis protein CFTR
chrIV	727710	728283	727710	728283	-	VPS61	YDR136C		727710,	728283,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  4% of ORF overlaps the verified gene RGP1  deletion causes a vacuolar protein sorting defect
chrIV	728258	730250	728258	730250	+	RGP1	YDR137W		728258,	730250,	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
chrIV	730577	732836	730577	732836	+	HPR1	YDR138W		730577,	732836,	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex  regulates lifespan  involved in telomere maintenance  similar to Top1p
chrIV	733617	733924	733617	733924	-	RUB1	YDR139C		733617,733775,	733702,733924,	Ubiquitin-like protein with similarity to mammalian NEDD8  conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p  activated by Ula1p and Uba3p (E1 enzyme pair)  conjugation mediated by Ubc12p (E2 enzyme)
chrIV	734137	734803	734137	734803	+	MTQ2	YDR140W		734137,	734803,	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family  subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP  similar to E.coli PrmC
chrIV	734900	739997	734900	739997	-	DOP1	YDR141C		734900,	739997,	Golgi-localized, leucine-zipper domain containing protein  involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis  detected in highly purified mitochondria in high-throughput studies
chrIV	740472	741600	740472	741600	-	PEX7	YDR142C		740472,	741600,	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins  WD repeat protein  defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
chrIV	742041	743874	742041	743874	-	SAN1	YDR143C		742041,	743874,	Ubiquitin-protein ligase  involved in the proteasome-dependent degradation of aberrant nuclear proteins  targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues  contains intrinsically disordered regions that contribute to substrate recognition
chrIV	744310	746101	744310	746101	-	MKC7	YDR144C		744310,	746101,	GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance  shares functions with Yap3p and Kex2p
chrIV	746737	748357	746737	748357	+	TAF12	YDR145W		746737,	748357,	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
chrIV	748612	750742	748612	750742	-	SWI5	YDR146C		748612,	750742,	Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase  localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
chrIV	751630	753235	751630	753235	+	EKI1	YDR147W		751630,	753235,	Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway  exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
chrIV	753674	755066	753674	755066	-	KGD2	YDR148C		753674,	755066,	Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle  phosphorylated
chrIV	755554	756262	755554	756262	-	YDR149C	YDR149C		755554,	756262,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  overlaps the verified gene NUM1  null mutation blocks anaerobic growth
chrIV	755627	763874	755627	763874	+	NUM1	YDR150W		755627,	763874,	Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip  may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
chrIV	764177	765155	764177	765155	-	CTH1	YDR151C		764177,	765155,	Member of the CCCH zinc finger family  has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation  may function with Tis11p in iron homeostasis
chrIV	765705	766503	765705	766503	+	GIR2	YDR152W		765705,	766503,	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function  forms a complex with Rbg2p  interacts with Rbg1p and Gcn1p  associates with translating ribosomes  putative intrinsically unstructured protein
chrIV	766735	767971	766735	767971	-	ENT5	YDR153C		766735,	767971,	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes  associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
chrIV	768402	768753	768402	768753	-	YDR154C	YDR154C		768402,	768753,	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
chrIV	768511	769000	768511	769000	-	CPR1	YDR155C		768511,	769000,	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  binds the drug cyclosporin A
chrIV	769524	769938	769524	769938	+	RPA14	YDR156W		769524,	769938,	RNA polymerase I subunit A14
chrIV	769930	770332	769930	770332	+	YDR157W	YDR157W		769930,	770332,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	770356	771454	770356	771454	+	HOM2	YDR158W		770356,	771454,	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis  expression regulated by Gcn4p and the general control of amino acid synthesis
chrIV	771876	775782	771876	775782	+	SAC3	YDR159W		771876,	775782,	Nuclear pore-associated protein  required for biogenesis of the small ribosomal subunit  component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus  involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP  mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
chrIV	776162	778721	776162	778721	+	SSY1	YDR160W		776162,	778721,	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
chrIV	779042	780206	779042	780206	+	YDR161W	YDR161W		779042,	780206,	Putative protein of unknown function  non-essential gene  proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation  genetic interactions suggest a role in ER-associated protein degradation (ERAD)
chrIV	780389	781100	780389	781100	-	NBP2	YDR162C		780389,	781100,	Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
chrIV	781422	781950	781422	781950	+	CWC15	YDR163W		781422,	781950,	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p  has similarity to S. pombe Cwf15p
chrIV	782040	784215	782040	784215	-	SEC1	YDR164C		782040,	784215,	Sm-like protein involved in docking and fusion of exocytic vesicles  binds to assembled SNARE complexes at the membrane and stimulates membrane fusion  localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
chrIV	784870	786205	784870	786205	+	TRM82	YDR165W		784870,	786205,	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
chrIV	786305	789221	786305	789221	-	SEC5	YDR166C		786305,	789221,	Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
chrIV	789448	790069	789448	790069	+	TAF10	YDR167W		789448,	790069,	Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
chrIV	790327	791848	790327	791848	+	CDC37	YDR168W		790327,	791848,	Essential Hsp90p co-chaperone  necessary for passage through the START phase of the cell cycle  stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
chrIV	792347	793889	792347	793889	-	STB3	YDR169C		792347,	793889,	Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth  restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion  binds Sin3p
chrIV	794573	794723	794573	794723	-	YDR169C-A	YDR169C-A		794573,	794723,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrIV	796192	802222	796192	802222	-	SEC7	YDR170C		796192,	802222,	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport  found in the cytoplasm and on Golgi-associated coated vesicles
chrIV	803194	804517	803194	804517	+	YDR170W-A	YDR170W-A		803194,	804517,	Retrotransposon TYA Gag gene  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag  YDR170W-A is part of a mutant retrotransposon
chrIV	806620	807748	806620	807748	+	HSP42	YDR171W		806620,	807748,	Small heat shock protein (sHSP) with chaperone activity  forms barrel-shaped oligomers that suppress unfolded protein aggregation  involved in cytoskeleton reorganization after heat shock
chrIV	808323	810381	808323	810381	+	SUP35	YDR172W		808323,	810381,	Translation termination factor eRF3, has a role in mRNA deadenylation and decay  altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
chrIV	810564	811632	810564	811632	-	ARG82	YDR173C		810564,	811632,	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5  also has diphosphoinositol polyphosphate synthase activity  regulates arginine-, phosphate-, and nitrogen-responsive genes
chrIV	812109	812850	812109	812850	+	HMO1	YDR174W		812109,	812850,	Chromatin associated high mobility group (HMG) family member involved in genome maintenance  rDNA-binding component of the Pol I transcription system  associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
chrIV	813192	814152	813192	814152	-	RSM24	YDR175C		813192,	814152,	Mitochondrial ribosomal protein of the small subunit
chrIV	814451	816560	814451	816560	+	NGG1	YDR176W		814451,	816560,	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes  component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
chrIV	816877	817525	816877	817525	+	UBC1	YDR177W		816877,	817525,	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins  plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD)  component of the cellular stress response
chrIV	817949	818495	817949	818495	+	SDH4	YDR178W		817949,	818495,	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
chrIV	818707	819196	818707	819196	-	CSN9	YDR179C		818707,	819196,	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin)  involved in adaptation to pheromone signaling
chrIV	819432	820824	819432	820824	+	YDR179W-A	YDR179W-A		819432,	820824,	Putative protein of unknown function
chrIV	821294	825776	821294	825776	+	SCC2	YDR180W		821294,	825776,	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes  involved in establishing sister chromatid cohesion during DSB repair via histone H2AX  evolutionarily-conserved adherin
chrIV	825909	827355	825909	827355	-	SAS4	YDR181C		825909,	827355,	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing  required for the HAT activity of Sas2p
chrIV	827581	829057	827581	829057	+	CDC1	YDR182W		827581,	829057,	Putative lipid phosphatase of the endoplasmic reticulum  shows Mn2+ dependence and may affect Ca2+ signaling  mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution
chrIV	829150	829354	829150	829354	+	YDR182W-A	YDR182W-A		829150,	829354,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrIV	829584	830277	829584	830277	+	PLP1	YDR183W		829584,	830277,	Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding  has weak similarity to phosducins, which are G-protein regulators
chrIV	830396	830654	830396	830654	-	YDR183C-A	YDR183C-A		830396,	830654,	Dubious open reading frame unlikely to encode a functional protein  identified by fungal homology and RT-PCR
chrIV	830628	831513	830628	831513	-	ATC1	YDR184C		830628,	831513,	Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern
chrIV	831933	832473	831933	832473	-	UPS3	YDR185C		831933,	832473,	Mitochondrial protein of unknown function  similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels  null is viable but interacts synthetically with ups1 and ups2 mutations
chrIV	832858	835492	832858	835492	-	YDR186C	YDR186C		832858,	835492,	Putative protein of unknown function  may interact with ribosomes, based on co-purification experiments  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrIV	836227	836746	836227	836746	-	YDR187C	YDR187C		836227,	836746,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified, essential ORF CCT6/YDR188W
chrIV	836420	838061	836420	838061	+	CCT6	YDR188W		836420,	838061,	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo  contains an ATP-binding motif
chrIV	838391	840392	838391	840392	+	SLY1	YDR189W		838391,	840392,	Hydrophilic protein involved in vesicle trafficking between the ER and Golgi  SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
chrIV	840603	841995	840603	841995	-	RVB1	YDR190C		840603,	841995,	Essential protein involved in transcription regulation  component of chromatin remodeling complexes  required for assembly and function of the INO80 complex  also referred to as pontin  member of the RUVB-like protein family
chrIV	842336	843449	842336	843449	+	HST4	YDR191W		842336,	843449,	Member of the Sir2 family of NAD(+)-dependent protein deacetylases  involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
chrIV	843568	844861	843568	844861	-	NUP42	YDR192C		843568,	844861,	Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side  involved in RNA export, most likely at a terminal step  interacts with Gle1p
chrIV	844553	844952	844553	844952	+	YDR193W	YDR193W		844553,	844952,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	845951	847946	845951	847946	-	MSS116	YDR194C		845951,	847946,	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns  non-polar RNA helicase that also facilities strand annealing
chrIV	848070	848223	848070	848223	+	YDR194W-A	YDR194W-A		848070,	848223,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrIV	848598	850200	848598	850200	+	REF2	YDR195W		848598,	850200,	RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation  part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
chrIV	850273	850999	850273	850999	-	CAB5	YDR196C		850273,	850999,	Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis  null mutant lethality is complemented by E. coli coaE (encoding DPCK)  detected in purified mitochondria in high-throughput studies
chrIV	851227	852397	851227	852397	+	CBS2	YDR197W		851227,	852397,	Mitochondrial translational activator of the COB mRNA  interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
chrIV	852532	853972	852532	853972	-	RKM2	YDR198C		852532,	853972,	Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp
chrIV	854174	854540	854174	854540	+	YDR199W	YDR199W		854174,	854540,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene VPS64  computationally predicted to have thiol-disulfide oxidoreductase activity
chrIV	854278	856093	854278	856093	-	VPS64	YDR200C		854278,	856093,	Protein required for cytoplasm to vacuole targeting of proteins  forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest  mutant has increased aneuploidy tolerance
chrIV	856316	856814	856316	856814	+	SPC19	YDR201W		856316,	856814,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  also localized to nuclear side of spindle pole body
chrIV	856897	857953	856897	857953	-	RAV2	YDR202C		856897,	857953,	Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
chrIV	857681	857999	857681	857999	+	YDR203W	YDR203W		857681,	857999,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	858136	859144	858136	859144	+	COQ4	YDR204W		858136,	859144,	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p  located on the matrix face of the mitochondrial inner membrane  component of a mitochondrial ubiquinone-synthesizing complex
chrIV	859345	861520	859345	861520	+	MSC2	YDR205W		859345,	861520,	Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus  mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
chrIV	862053	864708	862053	864708	+	EBS1	YDR206W		862053,	864708,	Protein involved in inhibition of translation and nonsense-mediated decay  interacts with cap binding protein Cdc33p and with Nam7p  localizes to P-bodies upon glucose starvation  mRNA abundance regulated by mRNA decay factors
chrIV	865011	867522	865011	867522	-	UME6	YDR207C		865011,	867522,	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
chrIV	868223	870563	868223	870563	+	MSS4	YDR208W		868223,	870563,	Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis  multicopy suppressor of stt4 mutation
chrIV	871035	871449	871035	871449	-	YDR209C	YDR209C		871035,	871449,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps uncharacterized gene YDR210W.
chrIV	871073	871301	871073	871301	+	YDR210W	YDR210W		871073,	871301,	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module  related proteins in other organisms may be involved in response to stress  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
chrIV	872111	877425	872111	877425	+	YDR210W-B	YDR210W-B		872111,873405,	873404,877425,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIV	872111	873428	872111	873428	+	YDR210W-A	YDR210W-A		872111,	873428,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIV	878658	883927	878658	883927	-	YDR210C-D	YDR210C-D		878658,882622,	882621,883927,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIV	882604	883927	882604	883927	-	YDR210C-C	YDR210C-C		882604,	883927,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIV	884726	886865	884726	886865	+	GCD6	YDR211W		884726,	886865,	Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2  activity subsequently regulated by phosphorylated eIF2  first identified as a negative regulator of GCN4 expression
chrIV	887231	888911	887231	888911	+	TCP1	YDR212W		887231,	888911,	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol  involved in actin cytoskeleton maintenance  overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
chrIV	889750	892492	889750	892492	+	UPC2	YDR213W		889750,	892492,	Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products  Ecm22p homolog  relocates from intracellular membranes to perinuclear foci on sterol depletion
chrIV	892874	893927	892874	893927	+	AHA1	YDR214W		892874,	893927,	Co-chaperone that binds to Hsp82p and activates its ATPase activity  similar to Hch1p  expression is regulated by stresses such as heat shock
chrIV	894088	894502	894088	894502	-	YDR215C	YDR215C		894088,	894502,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
chrIV	895034	899006	895034	899006	+	ADR1	YDR216W		895034,	899006,	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
chrIV	899550	903480	899550	903480	-	RAD9	YDR217C		899550,	903480,	DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M  transmits checkpoint signal by activating Rad53p and Chk1p  hyperphosphorylated by Mec1p and Tel1p  potential Cdc28p substrate
chrIV	903780	905052	903780	905052	-	SPR28	YDR218C		903780,	905052,	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes  meiotic septin expressed at high levels during meiotic divisions and ascospore formation
chrIV	905454	906852	905454	906852	-	MFB1	YDR219C		905454,	906852,	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology  interacts with Skp1p through the F-box motif  preferentially localizes to the mother cell during budding
chrIV	906999	907293	906999	907293	-	YDR220C	YDR220C		906999,	907293,	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
chrIV	907329	909438	907329	909438	+	GTB1	YDR221W		907329,	909438,	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER
chrIV	910053	911301	910053	911301	+	YDR222W	YDR222W		910053,	911301,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrIV	912098	913502	912098	913502	+	CRF1	YDR223W		912098,	913502,	Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus  role in repression of RP genes varies by strain
chrIV	914316	914712	914316	914712	-	HTB1	YDR224C		914316,	914712,	Histone H2B, core histone protein required for chromatin assembly and chromosome function  nearly identical to HTB2  Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
chrIV	915529	915928	915529	915928	+	HTA1	YDR225W		915529,	915928,	Histone H2A, core histone protein required for chromatin assembly and chromosome function  one of two nearly identical subtypes (see also HTA2)  DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair  acetylated by Nat4p
chrIV	916485	917154	916485	917154	+	ADK1	YDR226W		916485,	917154,	Adenylate kinase, required for purine metabolism  localized to the cytoplasm and the mitochondria  lacks cleavable signal sequence
chrIV	917570	921647	917570	921647	+	SIR4	YDR227W		917570,	921647,	Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci  potentially phosphorylated by Cdc28p  some alleles of SIR4 prolong lifespan
chrIV	921925	923806	921925	923806	-	PCF11	YDR228C		921925,	923806,	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination  binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
chrIV	924784	926146	924784	926146	+	IVY1	YDR229W		924784,	926146,	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
chrIV	926222	926570	926222	926570	+	YDR230W	YDR230W		926222,	926570,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene COX20
chrIV	926292	926910	926292	926910	-	COX20	YDR231C		926292,	926910,	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
chrIV	927451	929098	927451	929098	+	HEM1	YDR232W		927451,	929098,	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway  an N-terminal signal sequence is required for localization to the mitochondrial matrix  expression is regulated by Hap2p-Hap3p
chrIV	929469	930357	929469	930357	-	RTN1	YDR233C		929469,	930357,	ER membrane protein that interacts with Sey1p to maintain ER morphology  interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p  null mutant has an altered ER morphology  member of the RTNLA (reticulon-like A) subfamily
chrIV	931128	933210	931128	933210	+	LYS4	YDR234W		931128,	933210,	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
chrIV	933503	935138	933503	935138	+	PRP42	YDR235W		933503,	935138,	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis  contains multiple tetriatricopeptide repeats
chrIV	935235	935892	935235	935892	-	FMN1	YDR236C		935235,	935892,	Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes  localizes to microsomes and to the mitochondrial inner membrane
chrIV	936614	937493	936614	937493	+	MRPL7	YDR237W		936614,	937493,	Mitochondrial ribosomal protein of the large subunit
chrIV	937894	940816	937894	940816	-	SEC26	YDR238C		937894,	940816,	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology  shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
chrIV	941056	943420	941056	943420	-	YDR239C	YDR239C		941056,	943420,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
chrIV	943673	945152	943673	945152	-	SNU56	YDR240C		943673,	945152,	Component of U1 snRNP required for mRNA splicing via spliceosome  yeast specific, no metazoan counterpart  interacts with mRNA in commitment complex
chrIV	945150	945438	945150	945438	+	BUD26	YDR241W		945150,	945438,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  1% of ORF overlaps the verified gene SNU56  diploid mutant displays a weak budding pattern phenotype in a systematic assay
chrIV	946806	948456	946806	948456	+	AMD2	YDR242W		946806,	948456,	Putative amidase
chrIV	948517	950284	948517	950284	-	PRP28	YDR243C		948517,	950284,	RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
chrIV	950562	952401	950562	952401	+	PEX5	YDR244W		950562,	952401,	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import  also proposed to have PTS1-receptor independent functions
chrIV	952799	953981	952799	953981	+	MNN10	YDR245W		952799,	953981,	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone  membrane protein of the mannosyltransferase family
chrIV	954287	954947	954287	954947	+	TRS23	YDR246W		954287,	954947,	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion  involved in endoplasmic reticulum (ER) to Golgi membrane traffic  human homolog is TRAPPC4
chrIV	955132	955333	955132	955333	+	YDR246W-A	YDR246W-A		955132,	955333,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrIV	956012	957398	956012	957398	+	VHS1	YDR247W		956012,	957398,	Cytoplasmic serine/threonine protein kinase  identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression  homolog of Sks1p
chrIV	957757	958339	957757	958339	-	YDR248C	YDR248C		957757,	958339,	Putative protein of unknown function  sequence similarity to bacterial and human gluconokinase  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  upregulated by deletion of the RNAP-II associated factor, PAF1
chrIV	958680	959802	958680	959802	-	YDR249C	YDR249C		958680,	959802,	Putative protein of unknown function
chrIV	960085	960361	960085	960361	-	YDR250C	YDR250C		960085,	960361,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrIV	960613	963106	960613	963106	+	PAM1	YDR251W		960613,	963106,	Essential protein of unknown function  exhibits variable expression during colony morphogenesis  overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
chrIV	963411	963861	963411	963861	+	BTT1	YDR252W		963411,	963861,	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides  interacts with Caf130p of the CCR4-NOT complex  similar to human BTF3
chrIV	963989	964565	963989	964565	-	MET32	YDR253C		963989,	964565,	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p
chrIV	965112	966489	965112	966489	+	CHL4	YDR254W		965112,	966489,	Outer kinetochore protein required for chromosome stability  involved in new kinetochore assembly and sister chromatid cohesion  peripheral component of the Ctf19 kinetochore subcomplex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p
chrIV	966556	967822	966556	967822	-	RMD5	YDR255C		966556,	967822,	Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase  also required for sporulation  has a degenerate RING finger domain
chrIV	968132	969680	968132	969680	-	CTA1	YDR256C		968132,	969680,	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
chrIV	969989	971474	969989	971474	-	RKM4	YDR257C		969989,	971474,	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55)  nuclear SET-domain containing protein
chrIV	971807	974243	971807	974243	-	HSP78	YDR258C		971807,	974243,	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock  able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
chrIV	974630	975782	974630	975782	-	YAP6	YDR259C		974630,	975782,	Putative basic leucine zipper (bZIP) transcription factor  physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets  overexpression increases sodium and lithium tolerance  computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism
chrIV	976716	977229	976716	977229	-	SWM1	YDR260C		976716,	977229,	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis  required for activation of the daughter-specific gene expression and spore wall maturation
chrIV	977520	979209	977520	979209	-	EXG2	YDR261C		977520,	979209,	Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly  may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
chrIV	981461	986775	981461	986775	+	YDR261W-B	YDR261W-B		981461,982755,	982754,986775,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIV	981461	982778	981461	982778	+	YDR261W-A	YDR261W-A		981461,	982778,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIV	987533	992349	987533	992349	-	YDR261C-D	YDR261C-D		987533,991044,	991043,992349,	Retrotransposon TYA Gag and TYB Pol genes  in YDRCTY1-3 TYB is mutant and probably non-functional
chrIV	991026	992349	991026	992349	-	YDR261C-C	YDR261C-C		991026,	992349,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  in YDRCTY1-3 TYB is mutant and probably non-functional
chrIV	993133	993952	993133	993952	+	YDR262W	YDR262W		993133,	993952,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS  gene expression increases in response to Zymoliase treatment
chrIV	994241	995534	994241	995534	-	DIN7	YDR263C		994241,	995534,	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
chrIV	996028	998323	996028	998323	-	AKR1	YDR264C		996028,	998323,	Palmitoyl transferase involved in protein palmitoylation  acts as a negative regulator of pheromone response pathway  required for endocytosis of pheromone receptors  involved in cell shape control  contains ankyrin repeats
chrIV	998863	999877	998863	999877	+	PEX10	YDR265W		998863,	999877,	Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import  contains zinc-binding RING domain  mutations in human homolog cause various peroxisomal disorders
chrIV	1000103	1002023	1000103	1002023	-	YDR266C	YDR266C		1000103,	1002023,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  contains a RING finger domain
chrIV	1002509	1003502	1002509	1003502	-	CIA1	YDR267C		1002509,	1003502,	WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins  similar to the human Ciao1 protein  YDR267C is an essential gene
chrIV	1004003	1005143	1004003	1005143	+	MSW1	YDR268W		1004003,	1005143,	Mitochondrial tryptophanyl-tRNA synthetase
chrIV	1005664	1005988	1005664	1005988	-	YDR269C	YDR269C		1005664,	1005988,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1005674	1008689	1005674	1008689	+	CCC2	YDR270W		1005674,	1008689,	Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment  has similarity to human proteins involved in Menkes and Wilsons diseases
chrIV	1008394	1008766	1008394	1008766	-	YDR271C	YDR271C		1008394,	1008766,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF CCC2/YDR270W
chrIV	1009009	1009834	1009009	1009834	+	GLO2	YDR272W		1009009,	1009834,	Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
chrIV	1010175	1011273	1010175	1011273	+	DON1	YDR273W		1010175,	1011273,	Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
chrIV	1011588	1011960	1011588	1011960	-	YDR274C	YDR274C		1011588,	1011960,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1012251	1012959	1012251	1012959	+	BSC2	YDR275W		1012251,	1012959,	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
chrIV	1013475	1013643	1013475	1013643	-	PMP3	YDR276C		1013475,	1013643,	Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
chrIV	1014400	1015702	1014400	1015702	-	MTH1	YDR277C		1014400,	1015702,	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p  interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors  phosphorylated by Yck1p, triggering Mth1p degradation
chrIV	1017000	1017318	1017000	1017318	-	YDR278C	YDR278C		1017000,	1017318,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1019367	1020420	1019367	1020420	+	RNH202	YDR279W		1019367,	1020420,	Ribonuclease H2 subunit, required for RNase H2 activity  related to human AGS2 that causes Aicardi-Goutieres syndrome
chrIV	1020746	1021664	1020746	1021664	+	RRP45	YDR280W		1020746,	1021664,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)
chrIV	1022006	1022321	1022006	1022321	-	PHM6	YDR281C		1022006,	1022321,	Protein of unknown function, expression is regulated by phosphate levels
chrIV	1023510	1024755	1023510	1024755	-	YDR282C	YDR282C		1023510,	1024755,	Putative protein of unknown function
chrIV	1025069	1030049	1025069	1030049	-	GCN2	YDR283C		1025069,	1030049,	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation  activated by uncharged tRNAs and the Gcn1p-Gcn20p complex  contributes to DNA damage checkpoint control
chrIV	1030549	1031419	1030549	1031419	-	DPP1	YDR284C		1030549,	1031419,	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol  involved in lipid signaling and cell metabolism
chrIV	1032435	1035063	1032435	1035063	+	ZIP1	YDR285W		1032435,	1035063,	Transverse filament protein of the synaptonemal complex  required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis  potential Cdc28p substrate
chrIV	1035230	1035575	1035230	1035575	-	YDR286C	YDR286C		1035230,	1035575,	Putative protein of unknown function  predicted to have thiol-disulfide oxidoreductase active site
chrIV	1035994	1036873	1035994	1036873	+	INM2	YDR287W		1035994,	1036873,	Inositol monophosphatase, involved in biosynthesis of inositol  enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions  inm1 inm2 double mutant lacks inositol auxotrophy
chrIV	1037194	1038106	1037194	1038106	+	NSE3	YDR288W		1037194,	1038106,	Essential subunit of the Mms21-Smc5-Smc6 complex  protein of unknown function  required for DNA repair and growth
chrIV	1038279	1039509	1038279	1039509	-	RTT103	YDR289C		1038279,	1039509,	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain)  also involved in regulation of Ty1 transposition
chrIV	1039369	1039699	1039369	1039699	+	YDR290W	YDR290W		1039369,	1039699,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF RTT103
chrIV	1039727	1042961	1039727	1042961	+	HRQ1	YDR291W		1039727,	1042961,	Putative RecQ helicase  belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity  similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
chrIV	1043145	1045011	1043145	1045011	-	SRP101	YDR292C		1043145,	1045011,	Signal recognition particle (SRP) receptor alpha subunit  contain GTPase domains  involved in SRP-dependent protein targeting  interacts with the beta subunit, Srp102p
chrIV	1045639	1049392	1045639	1049392	-	SSD1	YDR293C		1045639,	1049392,	Translational repressor with a role in cell wall polar growth and integrity  regulated by Cbk1p phosphorylation to effect bud-specific translational control of specific mRNAs  interacts with TOR pathway components
chrIV	1050458	1052228	1050458	1052228	-	DPL1	YDR294C		1050458,	1052228,	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
chrIV	1052622	1054647	1052622	1054647	-	HDA2	YDR295C		1052622,	1054647,	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer  involved in telomere maintenance
chrIV	1055211	1055892	1055211	1055892	+	MHR1	YDR296W		1055211,	1055892,	Protein involved in homologous recombination in mitochondria  required for recombination-dependent mtDNA partitioning  involved in stimulation of mitochondrial DNA replication in response to oxidative stress
chrIV	1056550	1057600	1056550	1057600	+	SUR2	YDR297W		1056550,	1057600,	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
chrIV	1058175	1058814	1058175	1058814	-	ATP5	YDR298C		1058175,	1058814,	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis  homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein)  phosphorylated
chrIV	1059626	1061231	1059626	1061231	+	BFR2	YDR299W		1059626,	1061231,	Essential protein that is a component of 90S preribosomes  may be involved in rRNA processing  multicopy suppressor of sensitivity to Brefeldin A  expression is induced during lag phase and also by cold shock
chrIV	1061504	1062791	1061504	1062791	-	PRO1	YDR300C		1061504,	1062791,	Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
chrIV	1063351	1067425	1063351	1067425	+	CFT1	YDR301W		1063351,	1067425,	RNA-binding subunit of the mRNA cleavage and polyadenylation factor  involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
chrIV	1067730	1068390	1067730	1068390	+	GPI11	YDR302W		1067730,	1068390,	ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly  involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate  human PIG-Fp is a functional homolog
chrIV	1068728	1071386	1068728	1071386	-	RSC3	YDR303C		1068728,	1071386,	Component of the RSC chromatin remodeling complex  essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response  highly similar to Rsc30p
chrIV	1071879	1072557	1071879	1072557	-	CPR5	YDR304C		1071879,	1072557,	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  transcriptionally induced in response to unfolded proteins in the ER
chrIV	1072745	1073488	1072745	1073488	-	HNT2	YDR305C		1072745,1073401,	1073312,1073488,	Dinucleoside triphosphate hydrolase  has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
chrIV	1073734	1075171	1073734	1075171	-	YDR306C	YDR306C		1073734,	1075171,	F-box protein of unknown function  interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
chrIV	1075864	1077853	1075864	1077853	+	YDR307W	YDR307W		1075864,	1077853,	Putative protein of unknown function
chrIV	1078026	1078449	1078026	1078449	-	SRB7	YDR308C		1078026,	1078449,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation  target of the global repressor Tup1p
chrIV	1079047	1080199	1079047	1080199	-	GIC2	YDR309C		1079047,	1080199,	Redundant rho-like GTPase Cdc42p effector  homolog of Gic1p  involved in initiation of budding and cellular polarization  interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
chrIV	1081127	1084316	1081127	1084316	-	SUM1	YDR310C		1081127,	1084316,	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes  also acts as general replication initiation factor  involved in telomere maintenance, chromatin silencing  regulated by pachytene checkpoint
chrIV	1085064	1086993	1085064	1086993	+	TFB1	YDR311W		1085064,	1086993,	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
chrIV	1087580	1088942	1087580	1088942	+	SSF2	YDR312W		1087580,	1088942,	Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p  member of the Brix family
chrIV	1089218	1090079	1089218	1090079	-	PIB1	YDR313C		1089218,	1090079,	RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate  contains a FYVE finger domain
chrIV	1090432	1092511	1090432	1092511	-	RAD34	YDR314C		1090432,	1092511,	Protein involved in nucleotide excision repair (NER)  homologous to RAD4
chrIV	1092740	1093586	1092740	1093586	-	IPK1	YDR315C		1092740,	1093586,	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function  has 2 motifs conserved in other fungi  ipk1 gle1 double mutant is inviable
chrIV	1093762	1095178	1093762	1095178	+	OMS1	YDR316W		1093762,	1095178,	Protein integral to the mitochondrial membrane  has a conserved methyltransferase motif  multicopy suppressor of respiratory defects caused by OXA1 mutations
chrIV	1096063	1101332	1096063	1101332	+	YDR316W-B	YDR316W-B		1096063,1097369,	1097368,1101332,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIV	1096063	1097386	1096063	1097386	+	YDR316W-A	YDR316W-A		1096063,	1097386,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIV	1102183	1103428	1102183	1103428	+	HIM1	YDR317W		1102183,	1103428,	Protein of unknown function involved in DNA repair
chrIV	1103757	1104947	1103757	1104947	+	MCM21	YDR318W		1103757,1103892,	1103809,1104947,	Protein involved in minichromosome maintenance  component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
chrIV	1105002	1105827	1105002	1105827	-	YDR319C	YDR319C		1105002,	1105827,	Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis  interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens
chrIV	1106094	1108101	1106094	1108101	-	SWA2	YDR320C		1106094,	1108101,	Auxilin-like protein involved in vesicular transport  clathrin-binding protein required for uncoating of clathrin-coated vesicles
chrIV	1108279	1108498	1108279	1108498	-	DAD4	YDR320C-A		1108279,	1108498,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  is transferred to the kinetochore prior to mitosis
chrIV	1108483	1108621	1108483	1108621	+	YDR320W-B	YDR320W-B		1108483,	1108621,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene DAD4/YDR320C-A
chrIV	1108701	1109847	1108701	1109847	+	ASP1	YDR321W		1108701,	1109847,	Cytosolic L-asparaginase, involved in asparagine catabolism
chrIV	1110588	1111692	1110588	1111692	+	MRPL35	YDR322W		1110588,	1111692,	Mitochondrial ribosomal protein of the large subunit
chrIV	1112002	1112293	1112002	1112293	-	TIM11	YDR322C-A		1112002,	1112293,	Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis  essential for the dimeric and oligomeric state of ATP synthase
chrIV	1112479	1114027	1112479	1114027	-	PEP7	YDR323C		1112479,	1114027,	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome  required for vacuole inheritance
chrIV	1114432	1116763	1114432	1116763	-	UTP4	YDR324C		1114432,	1116763,	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit  member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
chrIV	1117125	1120233	1117125	1120233	+	YCG1	YDR325W		1117125,	1120233,	Subunit of the condensin complex  required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex  required for clustering of tRNA genes at the nucleolus
chrIV	1120608	1124925	1120608	1124925	-	YSP2	YDR326C		1120608,	1124925,	Protein involved in programmed cell death  mutant shows resistance to cell death induced by amiodarone or intracellular acidification
chrIV	1125301	1125628	1125301	1125628	+	YDR327W	YDR327W		1125301,	1125628,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the verified gene SKP1
chrIV	1125433	1126018	1125433	1126018	-	SKP1	YDR328C		1125433,	1126018,	Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
chrIV	1126269	1127595	1126269	1127595	-	PEX3	YDR329C		1126269,	1127595,	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs  anchors peroxisome retention factor Inp1p at the peroxisomal membrane  interacts with Pex19p
chrIV	1127871	1129374	1127871	1129374	+	UBX5	YDR330W		1127871,	1129374,	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
chrIV	1129587	1130823	1129587	1130823	+	GPI8	YDR331W		1129587,	1130823,	ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins  human PIG-K protein is a functional homolog
chrIV	1131000	1133070	1131000	1133070	+	IRC3	YDR332W		1131000,	1133070,	Putative RNA helicase of the DEAH/D-box family  null mutant displays increased levels of spontaneous Rad52p foci  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
chrIV	1133259	1135431	1133259	1135431	-	YDR333C	YDR333C		1133259,	1135431,	Putative protein of unknown function
chrIV	1135931	1140476	1135931	1140476	+	SWR1	YDR334W		1135931,	1140476,	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
chrIV	1141167	1144842	1141167	1144842	+	MSN5	YDR335W		1141167,	1144842,	Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p  required for re-export of mature tRNAs after their retrograde import from the cytoplasm
chrIV	1145091	1146036	1145091	1146036	+	YDR336W	YDR336W		1145091,	1146036,	Putative protein of unknown function  sumoylated under stress conditions in a genome wide study  YDR336W is not an essential gene
chrIV	1146318	1147179	1146318	1147179	+	MRPS28	YDR337W		1146318,	1147179,	Mitochondrial ribosomal protein of the small subunit
chrIV	1147378	1149466	1147378	1149466	-	YDR338C	YDR338C		1147378,	1149466,	Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
chrIV	1149950	1150520	1149950	1150520	-	FCF1	YDR339C		1149950,	1150520,	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA  component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis  copurifies with Faf1p
chrIV	1150880	1151183	1150880	1151183	+	YDR340W	YDR340W		1150880,	1151183,	Putative protein of unknown function
chrIV	1151802	1153626	1151802	1153626	-	YDR341C	YDR341C		1151802,	1153626,	Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrIV	1154215	1155928	1154215	1155928	-	HXT7	YDR342C		1154215,	1155928,	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
chrIV	1159607	1161320	1159607	1161320	-	HXT6	YDR343C		1159607,	1161320,	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
chrIV	1162005	1162449	1162005	1162449	-	YDR344C	YDR344C		1162005,	1162449,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1162956	1164660	1162956	1164660	-	HXT3	YDR345C		1162956,	1164660,	Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
chrIV	1167213	1168659	1167213	1168659	-	SVF1	YDR346C		1167213,	1168659,	Protein with a potential role in cell survival pathways, required for the diauxic growth shift  expression in mammalian cells increases survival under conditions inducing apoptosis  mutant has increased aneuploidy tolerance
chrIV	1169177	1170143	1169177	1170143	+	MRP1	YDR347W		1169177,	1170143,	Mitochondrial ribosomal protein of the small subunit  MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
chrIV	1170325	1171825	1170325	1171825	-	YDR348C	YDR348C		1170325,	1171825,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck  potential Cdc28p substrate
chrIV	1172385	1174176	1172385	1174176	-	YPS7	YDR349C		1172385,	1174176,	Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance  located in the cytoplasm and endoplasmic reticulum
chrIV	1176119	1178174	1176119	1178174	-	ATP22	YDR350C		1176119,	1178174,	Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase  localized to the mitochondrial inner membrane
chrIV	1178665	1181260	1178665	1181260	+	SBE2	YDR351W		1178665,	1181260,	Protein involved in the transport of cell wall components from the Golgi to the cell surface  required for bud growth
chrIV	1181800	1182754	1181800	1182754	+	YDR352W	YDR352W		1181800,	1182754,	Putative protein of unknown function
chrIV	1183298	1184258	1183298	1184258	+	TRR1	YDR353W		1183298,	1184258,	Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
chrIV	1184746	1185889	1184746	1185889	+	TRP4	YDR354W		1184746,	1185889,	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
chrIV	1185138	1185282	1185138	1185282	-	YDR354C-A	YDR354C-A		1185138,	1185282,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  completely overlaps TRP4  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrIV	1186066	1186369	1186066	1186369	-	YDR355C	YDR355C		1186066,	1186369,	Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified essential ORF SPC110/YDR356W
chrIV	1186106	1188941	1186106	1188941	+	SPC110	YDR356W		1186106,	1188941,	Inner plaque spindle pole body (SPB) component, ortholog of human kendrin  involved in connecting nuclear microtubules to SPB  interacts with Tub4p-complex and calmodulin  phosphorylated by Mps1p in cell cycle-dependent manner
chrIV	1189198	1189567	1189198	1189567	-	CNL1	YDR357C		1189198,	1189567,	Protein of unknown function  likely member of BLOC complex involved in endosomal cargo sorting  null mutant is sensitive to drug inducing secretion of vacuolar cargo  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrIV	1190058	1191732	1190058	1191732	+	GGA1	YDR358W		1190058,	1191732,	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
chrIV	1191935	1194884	1191935	1194884	-	EAF1	YDR359C		1191935,	1194884,	Component of the NuA4 histone acetyltransferase complex  acts as a platform for assembly of NuA4 subunits into the native complex  required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
chrIV	1194597	1195032	1194597	1195032	+	OPI7	YDR360W		1194597,	1195032,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene VID21/YDR359C.
chrIV	1195411	1196263	1195411	1196263	-	BCP1	YDR361C		1195411,	1196263,	Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
chrIV	1196678	1198697	1196678	1198697	-	TFC6	YDR362C		1196678,	1198697,	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC)  part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes  cooperates with Tfc3p in DNA binding  human homolog is TFIIIC-110
chrIV	1199182	1200553	1199182	1200553	+	ESC2	YDR363W		1199182,	1200553,	Sumo-like domain protein  prevents accumulation of toxic intermediates during replication-associated recombinational repair  roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint  RENi family member
chrIV	1202127	1202397	1202127	1202397	+	SEM1	YDR363W-A		1202127,	1202397,	Component of the lid subcomplex of the regulatory subunit of the 26S proteasome  involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p)  ortholog of human DSS1
chrIV	1202842	1204210	1202842	1204210	-	CDC40	YDR364C		1202842,	1204210,	Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression  required for DNA synthesis during mitosis and meiosis  has WD repeats
chrIV	1204496	1206383	1204496	1206383	-	ESF1	YDR365C		1204496,	1206383,	Nucleolar protein involved in pre-rRNA processing  depletion causes severely decreased 18S rRNA levels
chrIV	1206996	1212265	1206996	1212265	+	YDR365W-B	YDR365W-B		1206996,1208302,	1208301,1212265,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIV	1206996	1208319	1206996	1208319	+	YDR365W-A	YDR365W-A		1206996,	1208319,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIV	1212437	1212836	1212437	1212836	-	YDR366C	YDR366C		1212437,	1212836,	Putative protein of unknown function
chrIV	1212847	1213614	1212847	1213614	+	KEI1	YDR367W		1212847,1212978,	1212877,1213614,	Component of inositol phosphorylceramide (IPC) synthase  forms a complex with Aur1p and regulates its activity  required for IPC synthase complex localization to the Golgi  post-translationally processed by Kex2p  KEI1 is an essential gene
chrIV	1213903	1214842	1213903	1214842	+	YPR1	YDR368W		1213903,	1214842,	NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress  functionally redundant with other aldo-keto reductases
chrIV	1215015	1217580	1215015	1217580	-	XRS2	YDR369C		1215015,	1217580,	Protein required for DNA repair  component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
chrIV	1217781	1219110	1217781	1219110	-	YDR370C	YDR370C		1217781,	1219110,	Putative protein of unknown function
chrIV	1219412	1220948	1219412	1220948	+	CTS2	YDR371W		1219412,	1220948,	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
chrIV	1219508	1219613	1219508	1219613	-	YDR371C-A	YDR371C-A		1219508,	1219613,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completeley overlaps the uncharacterized gene CTS2/YDR371W  identified by expression profiling and mass spectrometry
chrIV	1221111	1222149	1221111	1222149	-	VPS74	YDR372C		1221111,	1222149,	Protein required for Golgi localization of glycosyltransferases  binds the cytosolic domains of Golgi glycosyltransferases  binding to PtdIns4P required for Golgi targeting and function  tetramer formation required for function
chrIV	1222758	1223331	1222758	1223331	+	FRQ1	YDR373W		1222758,	1223331,	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p  member of the recoverin/frequenin branch of the EF-hand superfamily
chrIV	1223473	1224394	1223473	1224394	-	YDR374C	YDR374C		1223473,	1224394,	Putative protein of unknown function
chrIV	1224756	1225026	1224756	1225026	+	YDR374W-A	YDR374W-A		1224756,	1225026,	Putative protein of unknown function
chrIV	1225165	1226536	1225165	1226536	-	BCS1	YDR375C		1225165,	1226536,	Mitochondrial protein of the AAA ATPase family  has ATP-dependent chaperone activity  required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex  mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases
chrIV	1226821	1228303	1226821	1228303	+	ARH1	YDR376W		1226821,	1228303,	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes  one of the few mitochondrial proteins essential for viability
chrIV	1228610	1228916	1228610	1228916	+	ATP17	YDR377W		1228610,	1228916,	Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
chrIV	1229348	1229609	1229348	1229609	-	LSM6	YDR378C		1229348,	1229609,	Lsm (Like Sm) protein  part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay  nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
chrIV	1230166	1233196	1230166	1233196	+	RGA2	YDR379W		1230166,	1233196,	GTPase-activating protein for the polarity-establishment protein Cdc42p  implicated in control of septin organization, pheromone response, and haploid invasive growth  regulated by Pho85p and Cdc28p
chrIV	1233277	1233517	1233277	1233517	-	YDR379C-A	YDR379C-A		1233277,	1233517,	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex  mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy
chrIV	1234217	1236125	1234217	1236125	+	ARO10	YDR380W		1234217,	1236125,	Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
chrIV	1236557	1238004	1236557	1238004	+	YRA1	YDR381W		1236557,1237608,	1236842,1238004,	RNA binding protein required for export of poly(A)+ mRNA from the nucleus  proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p  functionally redundant with Yra2p, another REF family member
chrIV	1238311	1238850	1238311	1238850	-	YDR381C-A	YDR381C-A		1238311,1238824,	1238630,1238850,	Protein of unknown function, localized to the mitochondrial outer membrane
chrIV	1239491	1239824	1239491	1239824	+	RPP2B	YDR382W		1239491,	1239824,	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome  regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
chrIV	1239959	1240676	1239959	1240676	-	NKP1	YDR383C		1239959,	1240676,	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
chrIV	1241203	1242031	1241203	1242031	-	ATO3	YDR384C		1241203,	1242031,	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell  phosphorylated in mitochondria  member of the TC 9.B.33 YaaH family of putative transporters
chrIV	1243229	1245758	1243229	1245758	+	EFT2	YDR385W		1243229,	1245758,	Elongation factor 2 (EF-2), also encoded by EFT1  catalyzes ribosomal translocation during protein synthesis  contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
chrIV	1246083	1247982	1246083	1247982	+	MUS81	YDR386W		1246083,	1247982,	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA  involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination  helix-hairpin-helix protein
chrIV	1248153	1249821	1248153	1249821	-	YDR387C	YDR387C		1248153,	1249821,	Putative transporter, member of the sugar porter family  YDR387C is not an essential gene
chrIV	1250185	1251634	1250185	1251634	+	RVS167	YDR388W		1250185,	1251634,	Actin-associated protein with roles in endocytosis and exocytosis  interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress  recruited to bud tips by Gyl1p and Gyp5p during polarized growth  homolog of mammalian amphiphysin
chrIV	1252536	1254501	1252536	1254501	+	SAC7	YDR389W		1252536,	1254501,	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin  potential Cdc28p substrate
chrIV	1254936	1256847	1254936	1256847	-	UBA2	YDR390C		1254936,	1256847,	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p  activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting  essential for viability
chrIV	1257357	1258056	1257357	1258056	-	YDR391C	YDR391C		1257357,	1258056,	Putative protein of unknown function, possibly involved in zinc homeostasis  Bdf1p-dependent transcription induced by salt stress  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrIV	1258695	1259709	1258695	1259709	+	SPT3	YDR392W		1258695,	1259709,	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
chrIV	1259900	1261271	1259900	1261271	+	SHE9	YDR393W		1259900,	1261271,	Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane  forms a homo-oligomeric complex
chrIV	1261680	1262967	1261680	1262967	+	RPT3	YDR394W		1261680,	1262967,	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates  substrate of N-acetyltransferase B
chrIV	1263323	1266158	1263323	1266158	+	SXM1	YDR395W		1263323,	1266158,	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm  similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
chrIV	1266294	1266795	1266294	1266795	+	YDR396W	YDR396W		1266294,	1266795,	Dubious open reading frame unlikely to encode a functional protein  extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
chrIV	1266365	1266898	1266365	1266898	-	NCB2	YDR397C		1266365,1266861,	1266769,1266898,	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p  complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription  homologous to human NC2beta
chrIV	1267470	1269402	1267470	1269402	+	UTP5	YDR398W		1267470,	1269402,	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
chrIV	1270067	1270733	1270067	1270733	+	HPT1	YDR399W		1270067,	1270733,	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate  mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
chrIV	1271062	1272085	1271062	1272085	+	URH1	YDR400W		1271062,	1272085,	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides  involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
chrIV	1272222	1272786	1272222	1272786	+	YDR401W	YDR401W		1272222,	1272786,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1272233	1273703	1272233	1273703	-	DIT2	YDR402C		1272233,	1273703,	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s
chrIV	1274601	1276212	1274601	1276212	+	DIT1	YDR403W		1274601,	1276212,	Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall  transcripts accumulate at the time of prospore enclosure
chrIV	1276653	1277169	1276653	1277169	-	RPB7	YDR404C		1276653,	1277169,	RNA polymerase II subunit B16  forms two subunit dissociable complex with Rpb4p  involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions  also involved in translation initiation
chrIV	1277645	1278437	1277645	1278437	+	MRP20	YDR405W		1277645,	1278437,	Mitochondrial ribosomal protein of the large subunit
chrIV	1279209	1283799	1279209	1283799	+	PDR15	YDR406W		1279209,	1283799,	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification  regulated by Pdr1p, Pdr3p and Pdr8p  promoter contains a PDR responsive element
chrIV	1283798	1284044	1283798	1284044	+	YDR406W-A	YDR406W-A		1283798,	1284044,	Dubious open reading frame unlikely to encode a functional protein  identified by fungal homology and RT-PCR
chrIV	1284068	1287938	1284068	1287938	-	TRS120	YDR407C		1284068,	1287938,	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion  involved in endoplasmic reticulum (ER) to Golgi membrane traffic
chrIV	1288214	1288859	1288214	1288859	-	ADE8	YDR408C		1288214,	1288859,	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
chrIV	1289405	1292120	1289405	1292120	+	SIZ1	YDR409W		1289405,	1292120,	SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p  small ubiquitin-related modifier) to proteins  binds Ubc9p and may bind septins  specifically required for sumoylation of septins in vivo  localized to the septin ring
chrIV	1292371	1293091	1292371	1293091	-	STE14	YDR410C		1292371,	1293091,	Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane
chrIV	1293368	1294394	1293368	1294394	-	DFM1	YDR411C		1293368,	1294394,	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis  interacts with components of ERAD-L and ERAD-C and Cdc48p  derlin-like family member similar to Der1p
chrIV	1294692	1295400	1294692	1295400	+	RRP17	YDR412W		1294692,	1295400,	Component of the pre-60S pre-ribosomal particle  required for cell viability under standard (aerobic) conditions but not under anaerobic conditions  exonuclease required for 5&#8242  end processing of pre-60S ribosomal RNA
chrIV	1294835	1295411	1294835	1295411	-	YDR413C	YDR413C		1294835,	1295411,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
chrIV	1295597	1296686	1295597	1296686	-	ERD1	YDR414C		1295597,	1296686,	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins  mutants secrete the endogenous ER protein, BiP (Kar2p)
chrIV	1297036	1298161	1297036	1298161	-	YDR415C	YDR415C		1297036,	1298161,	Putative protein of unknown function
chrIV	1298431	1301011	1298431	1301011	+	SYF1	YDR416W		1298431,	1301011,	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs  null mutant has splicing defect and arrests in G2/M  homologs in human and C. elegans
chrIV	1301554	1301926	1301554	1301926	-	YDR417C	YDR417C		1301554,	1301926,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF RPL12B/YDR418W
chrIV	1301615	1302113	1301615	1302113	+	RPL12B	YDR418W		1301615,	1302113,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap  rpl12a rpl12b double mutant exhibits slow growth and slow translation  has similarity to E. coli L11 and rat L12 ribosomal proteins
chrIV	1303173	1305072	1303173	1305072	+	RAD30	YDR419W		1303173,	1305072,	DNA polymerase eta, involved in translesion synthesis during post-replication repair  catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions  mutations in human pol eta are responsible for XPV
chrIV	1306266	1311675	1306266	1311675	+	HKR1	YDR420W		1306266,	1311675,	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p  proposed to be a negative regulator of filamentous growth  mutant displays defects in beta-1,3 glucan synthesis and bud site selection
chrIV	1312039	1314892	1312039	1314892	+	ARO80	YDR421W		1312039,	1314892,	Zinc finger transcriptional activator of the Zn2Cys6 family  activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
chrIV	1315325	1317773	1315325	1317773	-	SIP1	YDR422C		1315325,	1317773,	Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity  vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
chrIV	1318045	1319275	1318045	1319275	-	CAD1	YDR423C		1318045,	1319275,	AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance  controls a set of genes involved in stabilizing proteins  binds consensus sequence TTACTAA
chrIV	1319386	1319841	1319386	1319841	-	DYN2	YDR424C		1319386,1319697,1319816,	1319617,1319720,1319841,	Cytoplasmic light chain dynein, microtubule motor protein  proposed to be involved in the assembly of the nuclear pore complex
chrIV	1320063	1321941	1320063	1321941	+	SNX41	YDR425W		1320063,	1321941,	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network  interacts with Snx4p
chrIV	1321628	1322006	1321628	1322006	-	YDR426C	YDR426C		1321628,	1322006,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF SNX41
chrIV	1322204	1323386	1322204	1323386	+	RPN9	YDR427W		1322204,	1323386,	Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species  null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
chrIV	1323453	1324239	1323453	1324239	-	BNA7	YDR428C		1323453,	1324239,	Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
chrIV	1324476	1325301	1324476	1325301	-	TIF35	YDR429C		1324476,	1325301,	eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation  stimulates resumption of ribosomal scanning during translation reinitiation
chrIV	1325500	1328470	1325500	1328470	-	CYM1	YDR430C		1325500,	1328470,	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family  degrades proteins and presequence peptides cleaved from imported proteins  required for normal mitochondrial morphology
chrIV	1328389	1328701	1328389	1328701	+	YDR431W	YDR431W		1328389,	1328701,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1328782	1330027	1328782	1330027	+	NPL3	YDR432W		1328782,	1330027,	RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm  required for pre-mRNA splicing  dissociation from mRNAs promoted by Mtr10p  phosphorylated by Sky1p in the cytoplasm
chrIV	1329599	1330040	1329599	1330040	+	YDR433W	YDR433W		1329599,	1330040,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1331236	1332841	1331236	1332841	+	GPI17	YDR434W		1331236,	1332841,	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins  human PIG-Sp homolog
chrIV	1332982	1333969	1332982	1333969	-	PPM1	YDR435C		1332982,	1333969,	Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
chrIV	1334820	1336953	1334820	1336953	+	PPZ2	YDR436W		1334820,	1336953,	Serine/threonine protein phosphatase Z, isoform of Ppz1p  involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
chrIV	1337351	1337774	1337351	1337774	+	GPI19	YDR437W		1337351,	1337774,	Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P
chrIV	1338273	1339386	1338273	1339386	+	THI74	YDR438W		1338273,	1339386,	Mitochondrial transporter repressible by thiamine
chrIV	1339675	1340719	1339675	1340719	+	LRS4	YDR439W		1339675,	1340719,	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation  required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
chrIV	1342492	1344241	1342492	1344241	+	DOT1	YDR440W		1342492,	1344241,	Nucleosomal histone H3-Lys79 methylase  methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
chrIV	1344516	1345062	1344516	1345062	-	APT2	YDR441C		1344516,	1345062,	Apparent pseudogene, not transcribed or translated under normal conditions  encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
chrIV	1345646	1346039	1345646	1346039	+	YDR442W	YDR442W		1345646,	1346039,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1345675	1349938	1345675	1349938	-	SSN2	YDR443C		1345675,	1349938,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  required for stable association of Srb10p-Srb11p kinase  essential for transcriptional regulation
chrIV	1350289	1352353	1350289	1352353	+	YDR444W	YDR444W		1350289,	1352353,	Putative protein of unknown function
chrIV	1352181	1352589	1352181	1352589	-	YDR445C	YDR445C		1352181,	1352589,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1353724	1354633	1353724	1354633	+	ECM11	YDR446W		1353724,	1354633,	Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis  may be involved in maintaining chromatin structure
chrIV	1354828	1355553	1354828	1355553	-	RPS17B	YDR447C		1354828,1355550,	1355236,1355553,	Ribosomal protein 51 (rp51) of the small (40s) subunit  nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
chrIV	1356064	1357369	1356064	1357369	+	ADA2	YDR448W		1356064,	1357369,	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
chrIV	1357579	1358902	1357579	1358902	-	UTP6	YDR449C		1357579,	1358902,	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
chrIV	1359922	1360798	1359922	1360798	+	RPS18A	YDR450W		1359922,1360404,	1359969,1360798,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
chrIV	1361119	1362181	1361119	1362181	-	YHP1	YDR451C		1361119,	1362181,	One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
chrIV	1362877	1364902	1362877	1364902	+	PPN1	YDR452W		1362877,	1364902,	Vacuolar endopolyphosphatase with a role in phosphate metabolism  functions as a homodimer
chrIV	1365071	1365662	1365071	1365662	-	TSA2	YDR453C		1365071,	1365662,	Stress inducible cytoplasmic thioredoxin peroxidase  cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor  deletion enhances the mutator phenotype of tsa1 mutants
chrIV	1366263	1366827	1366263	1366827	-	GUK1	YDR454C		1366263,	1366827,	Guanylate kinase, converts GMP to GDP  required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
chrIV	1367372	1367681	1367372	1367681	-	YDR455C	YDR455C		1367372,	1367681,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YDR456W
chrIV	1367484	1369386	1367484	1369386	+	NHX1	YDR456W		1367484,	1369386,	Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+  located in the vacuole and late endosome compartments  required for osmotolerance to acute hypertonic shock and for vacuolar fusion
chrIV	1369789	1379596	1369789	1379596	+	TOM1	YDR457W		1369789,	1379596,	E3 ubiquitin ligase of the hect-domain class  has a role in mRNA export from the nucleus and may regulate transcriptional coactivators  involved in degradation of excess histones
chrIV	1380054	1382046	1380054	1382046	-	HEH2	YDR458C		1380054,	1382046,	Inner nuclear membrane (INM) protein  contains helix-extension-helix (HEH) motif, nuclear localization signal sequence  targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
chrIV	1382318	1383443	1382318	1383443	-	PFA5	YDR459C		1382318,	1383443,	Palmitoyltransferase with autoacylation activity  likely functions in pathway(s) outside Ras  member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
chrIV	1383810	1384776	1383810	1384776	+	TFB3	YDR460W		1383810,	1384776,	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair  ring finger protein similar to mammalian CAK and TFIIH subunit
chrIV	1385175	1385286	1385175	1385286	+	MFA1	YDR461W		1385175,	1385286,	Mating pheromone a-factor, made by a cells  interacts with alpha cells to induce cell cycle arrest and other responses leading to mating  biogenesis involves C-terminal modification, N-terminal proteolysis, and export  also encoded by MFA2
chrIV	1385523	1385766	1385523	1385766	-	YDR461C-A	YDR461C-A		1385523,	1385766,	Putative protein of unknown function
chrIV	1386072	1386516	1386072	1386516	+	MRPL28	YDR462W		1386072,	1386516,	Mitochondrial ribosomal protein of the large subunit
chrIV	1386815	1388375	1386815	1388375	+	STP1	YDR463W		1386815,	1388375,	Transcription factor, undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids  activates transcription of amino acid permease genes and may have a role in tRNA processing
chrIV	1388871	1393179	1388871	1393179	+	SPP41	YDR464W		1388871,	1393179,	Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
chrIV	1392491	1392680	1392491	1392680	-	YDR464C-A	YDR464C-A		1392491,	1392680,	Dubious open reading frame unlikely to encode a functional protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrIV	1393335	1394574	1393335	1394574	-	RMT2	YDR465C		1393335,	1394574,	Arginine N5 methyltransferase  methylates ribosomal protein Rpl12 (L12) on Arg67
chrIV	1395120	1397817	1395120	1397817	+	PKH3	YDR466W		1395120,	1397817,	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p  identified as a multicopy suppressor of a pkh1 pkh2 double mutant
chrIV	1397582	1397909	1397582	1397909	-	YDR467C	YDR467C		1397582,	1397909,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1398025	1398700	1398025	1398700	-	TLG1	YDR468C		1398025,	1398700,	Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi  binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
chrIV	1399014	1399542	1399014	1399542	+	SDC1	YDR469W		1399014,	1399542,	Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres  contains a Dpy-30 domain that mediates interaction with Bre2p  similar to C. elegans and human DPY-30
chrIV	1399705	1401214	1399705	1401214	-	UGO1	YDR470C		1399705,	1401214,	Outer membrane component of the mitochondrial fusion machinery  binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion  facilitates dimerization of Fzo1p during fusion
chrIV	1401769	1402564	1401769	1402564	+	RPL27B	YDR471W		1401769,1402184,	1401800,1402564,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
chrIV	1403321	1404173	1403321	1404173	+	TRS31	YDR472W		1403321,	1404173,	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion  involved in endoplasmic reticulum (ER) to Golgi membrane traffic
chrIV	1404444	1405854	1404444	1405854	-	PRP3	YDR473C		1404444,	1405854,	Splicing factor, component of the U4/U6-U5 snRNP complex
chrIV	1407463	1410094	1407463	1410094	-	JIP4	YDR475C		1407463,	1410094,	Protein of unknown function  previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
chrIV	1410452	1411127	1410452	1411127	-	YDR476C	YDR476C		1410452,	1411127,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  YDR476C is not an essential gene
chrIV	1412372	1414274	1412372	1414274	+	SNF1	YDR477W		1412372,	1414274,	AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family  required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
chrIV	1414574	1415171	1414574	1415171	+	SNM1	YDR478W		1414574,	1415171,	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs  binds to the NME1 RNA subunit of RNase MRP
chrIV	1415209	1416874	1415209	1416874	-	PEX29	YDR479C		1415209,	1416874,	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution  genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
chrIV	1417398	1418370	1417398	1418370	+	DIG2	YDR480W		1417398,	1418370,	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway  related regulators Dig1p and Dig2p bind to Ste12p
chrIV	1418549	1420250	1418549	1420250	-	PHO8	YDR481C		1418549,	1420250,	Repressible vacuolar alkaline phosphatase  regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p  dephosphorylates phosphotyrosyl peptides  contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
chrIV	1420430	1420838	1420430	1420838	-	CWC21	YDR482C		1420430,	1420838,	Protein involved in RNA splicing by the spliceosome  component of a complex containing Cef1p  interacts genetically with ISY1 and BUD13  may bind RNA  has similarity to S. pombe Cwf21p
chrIV	1421156	1422485	1421156	1422485	+	KRE2	YDR483W		1421156,	1422485,	Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation
chrIV	1422762	1424688	1422762	1424688	+	VPS52	YDR484W		1422762,	1424688,	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi  involved in localization of actin and chitin
chrIV	1424819	1427207	1424819	1427207	-	VPS72	YDR485C		1424819,	1427207,	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A  required for vacuolar protein sorting
chrIV	1427430	1428120	1427430	1428120	-	VPS60	YDR486C		1427430,	1428120,	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport  required for normal filament maturation during pseudohyphal growth  may function in targeting cargo proteins for degradation  interacts with Vta1p
chrIV	1428353	1428980	1428353	1428980	-	RIB3	YDR487C		1428353,	1428980,	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
chrIV	1429187	1430789	1429187	1430789	-	PAC11	YDR488C		1429187,	1430789,	Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p  null mutant is defective in nuclear migration, essential in the absence of CIN8
chrIV	1431011	1431896	1431011	1431896	+	SLD5	YDR489W		1431011,	1431896,	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
chrIV	1431967	1434268	1431967	1434268	-	PKH1	YDR490C		1431967,	1434268,	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis  activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity  redundant with Pkh2p
chrIV	1434499	1434991	1434499	1434991	-	YDR491C	YDR491C		1434499,	1434991,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1434923	1435874	1434923	1435874	+	IZH1	YDR492W		1434923,	1435874,	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family  transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids  deletion increases sensitivity to elevated zinc
chrIV	1436216	1436588	1436216	1436588	+	MZM1	YDR493W		1436216,	1436588,	Mitochondrial matrix protein with a role in maintaining the labile mitochondrial zinc pool  null mutant has a respiratory growth defect and an elevated frequency of mitochondrial genome loss  overexpression causes cell cycle delay or arrest
chrIV	1436929	1438015	1436929	1438015	+	RSM28	YDR494W		1436929,	1438015,	Mitochondrial ribosomal protein of the small subunit  genetic interactions suggest a possible role in promoting translation initiation
chrIV	1438114	1441150	1438114	1441150	-	VPS3	YDR495C		1438114,	1441150,	Component of CORVET tethering complex  cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
chrIV	1441432	1443403	1441432	1443403	-	PUF6	YDR496C		1441432,	1443403,	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA  also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
chrIV	1443712	1445467	1443712	1445467	-	ITR1	YDR497C		1443712,	1445467,	Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily  expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
chrIV	1445842	1446994	1445842	1446994	-	SEC20	YDR498C		1445842,	1446994,	Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER  required for N- and O-glycosylation in the Golgi but not in the ER  interacts with the Dsl1p complex through Tip20p
chrIV	1447829	1450073	1447829	1450073	+	LCD1	YDR499W		1447829,	1450073,	Essential protein required for the DNA integrity checkpoint pathways  interacts physically with Mec1p  putative homolog of S. pombe Rad26 and human ATRIP
chrIV	1450197	1450853	1450197	1450853	-	RPL37B	YDR500C		1450197,1450846,	1450457,1450853,	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
chrIV	1451352	1452918	1451352	1452918	+	PLM2	YDR501W		1451352,	1452918,	Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin  target of SBF transcription factor  induced in response to DNA damaging agents and deletion of telomerase  similar to TOS4
chrIV	1453309	1454464	1453309	1454464	-	SAM2	YDR502C		1453309,	1454464,	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine  one of two differentially regulated isozymes (Sam1p and Sam2p)
chrIV	1455041	1455866	1455041	1455866	-	LPP1	YDR503C		1455041,	1455866,	Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate  involved in control of the cellular levels of phosphatidylinositol and PA
chrIV	1456310	1456694	1456310	1456694	-	SPG3	YDR504C		1456310,	1456694,	Protein required for survival at high temperature during stationary phase  not required for growth on nonfermentable carbon sources
chrIV	1456694	1459220	1456694	1459220	-	PSP1	YDR505C		1456694,	1459220,	Asn and gln rich protein of unknown function  high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations  overexpression results in growth inhibition
chrIV	1459727	1461554	1459727	1461554	-	YDR506C	YDR506C		1459727,	1461554,	Possible membrane-localized protein
chrIV	1462357	1465786	1462357	1465786	-	GIN4	YDR507C		1462357,	1465786,	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities  undergoes autophosphorylation  similar to Kcc4p and Hsl1p
chrIV	1466452	1468444	1466452	1468444	-	GNP1	YDR508C		1466452,	1468444,	High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn  expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
chrIV	1468225	1468573	1468225	1468573	+	YDR509W	YDR509W		1468225,	1468573,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1469399	1469705	1469399	1469705	+	SMT3	YDR510W		1469399,	1469705,	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins  regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics  phosphorylated at Ser2
chrIV	1469694	1469811	1469694	1469811	-	YDR510C-A	YDR510C-A		1469694,	1469811,	Dubious open reading frame unlikely to encode a functional protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrIV	1470016	1470418	1470016	1470418	+	ACN9	YDR511W		1470016,	1470418,	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis  has orthologs in higher eukaryotes
chrIV	1470499	1471063	1470499	1471063	-	EMI1	YDR512C		1470499,	1471063,	Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation  contains twin cysteine-x9-cysteine motifs
chrIV	1471016	1471448	1471016	1471448	+	GRX2	YDR513W		1471016,	1471448,	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress
chrIV	1471547	1472999	1471547	1472999	-	YDR514C	YDR514C		1471547,	1472999,	Protein of unknown function that localizes to mitochondria  overexpression of YDR514C affects endocytic protein trafficking
chrIV	1473428	1474772	1473428	1474772	+	SLF1	YDR515W		1473428,	1474772,	RNA binding protein that associates with polysomes  proposed to be involved in regulating mRNA translation  involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts
chrIV	1474973	1476476	1474973	1476476	-	EMI2	YDR516C		1474973,	1476476,	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1  required for sporulation  expression is regulated by glucose-repression transcription factors Mig1/2p
chrIV	1477238	1478357	1477238	1478357	+	GRH1	YDR517W		1477238,	1478357,	Acetylated, cis-golgi localized protein involved in ER to Golgi transport  homolog of human GRASP65  forms a complex with the coiled-coil protein Bug1p  mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
chrIV	1478607	1480161	1478607	1480161	+	EUG1	YDR518W		1478607,	1480161,	Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p  may interact with nascent polypeptides in the ER
chrIV	1480424	1480832	1480424	1480832	+	FPR2	YDR519W		1480424,	1480832,	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin  expression pattern suggests possible involvement in ER protein trafficking
chrIV	1481084	1483403	1481084	1483403	-	URC2	YDR520C		1481084,	1483403,	Putative Zn(II)2Cys6 motif containing transcription factor  non-essential gene identified in a screen for mutants with increased levels of rDNA transcription  similar to S. kluyveri Urc2p involved in uracil catabolism
chrIV	1483140	1483476	1483140	1483476	+	YDR521W	YDR521W		1483140,	1483476,	Dubious ORF that overlaps YDR520C  mutant increases expression of PIS1 and RPL3 in glycerol
chrIV	1483794	1485303	1483794	1485303	-	SPS2	YDR522C		1483794,	1485303,	Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall  S. pombe ortholog is a spore wall component
chrIV	1485565	1487038	1485565	1487038	-	SPS1	YDR523C		1485565,	1487038,	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
chrIV	1487541	1488990	1487541	1488990	-	AGE1	YDR524C		1487541,	1488990,	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways  contains C2C2H2 cysteine/histidine motif
chrIV	1489402	1489492	1489402	1489492	+	YDR524W-C	YDR524W-C		1489402,	1489492,	Putative protein of unknown function  small ORF identified by SAGE  deletion strains are moderately sensitive to the radiomimetic drug bleomycin
chrIV	1489597	1489798	1489597	1489798	-	YDR524C-B	YDR524C-B		1489597,	1489798,	Putative protein of unknown function
chrIV	1489870	1489990	1489870	1489990	-	YDR524C-A	YDR524C-A		1489870,	1489990,	Dubious open reading frame unlikely to encode a functional protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrIV	1489904	1490234	1489904	1490234	+	API2	YDR525W		1489904,	1490234,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  26% of ORF overlaps the dubious ORF YDR524C-A  insertion mutation in a cdc34-2 mutant background causes altered bud morphology
chrIV	1490595	1490835	1490595	1490835	+	SNA2	YDR525W-A		1490595,	1490835,	Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrIV	1491074	1491545	1491074	1491545	-	YDR526C	YDR526C		1491074,	1491545,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1491093	1492413	1491093	1492413	+	RBA50	YDR527W		1491093,	1492413,	Protein involved in transcription  interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p  has similarity to human RPAP1
chrIV	1494585	1495857	1494585	1495857	+	HLR1	YDR528W		1494585,	1495857,	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress  overproduction suppresses a lysis sensitive PKC mutation  similar to Lre1p, which functions antagonistically to protein kinase A
chrIV	1496164	1496548	1496164	1496548	-	QCR7	YDR529C		1496164,	1496548,	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain  oriented facing the mitochondrial matrix  N-terminus appears to play a role in complex assembly
chrIV	1496790	1497768	1496790	1497768	-	APA2	YDR530C		1496790,	1497768,	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates  has similarity to Apa1p
chrIV	1498231	1499335	1498231	1499335	+	CAB1	YDR531W		1498231,	1499335,	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33)  catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA)  transcriptionally regulated by Upc2p via a sterol response element
chrIV	1499395	1500553	1499395	1500553	-	KRE28	YDR532C		1499395,	1500553,	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components
chrIV	1501446	1502160	1501446	1502160	-	HSP31	YDR533C		1501446,	1502160,	Possible chaperone and cysteine protease with similarity to E. coli Hsp31  member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease  exists as a dimer and contains a putative metal-binding site
chrIV	1503313	1504900	1503313	1504900	-	FIT1	YDR534C		1503313,	1504900,	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
chrIV	1506605	1507362	1506605	1507362	-	YDR535C	YDR535C		1506605,1507314,	1507058,1507362,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YDR535C is not an essential gene.
chrIV	1508004	1509714	1508004	1509714	+	STL1	YDR536W		1508004,	1509714,	Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
chrIV	1510855	1511461	1510855	1511461	-	YDR537C	YDR537C		1510855,	1511461,	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
chrIV	1510901	1511630	1510901	1511630	+	PAD1	YDR538W		1510901,	1511630,	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives  also has mRNA binding activity  homolog of E. coli UbiX
chrIV	1512093	1513605	1512093	1513605	+	FDC1	YDR539W		1512093,	1513605,	Putative phenylacrylic acid decarboxylase  essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives  homolog of E. coli UbiD  GFP-fusion protein localizes to the cytoplasm
chrIV	1517135	1517675	1517135	1517675	-	IRC4	YDR540C		1517135,	1517675,	Putative protein of unknown function  null mutant displays increased levels of spontaneous Rad52p foci  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
chrIV	1519663	1520698	1519663	1520698	-	YDR541C	YDR541C		1519663,	1520698,	Putative dihydrokaempferol 4-reductase
chrIV	1523248	1523611	1523248	1523611	+	PAU10	YDR542W		1523248,	1523611,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
chrIV	1524633	1524933	1524633	1524933	-	YDR543C	YDR543C		1524633,	1524933,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1525094	1525523	1525094	1525523	-	YDR544C	YDR544C		1525094,	1525523,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIV	1526320	1531711	1526320	1531711	+	YRF1-1	YDR545W		1526320,	1531711,	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1  potentially phosphorylated by Cdc28p
chrIV	1530862	1531342	1530862	1531342	-	YDR545C-A	YDR545C-A		1530862,	1531342,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF YRF1-1/YDR545W
chrIX	482	6147	482	6147	-	YIL177C	YIL177C		482,4986,	4598,6147,	Putative protein of unknown function  similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors
chrIX	845	1328	845	1328	+	YIL177W-A	YIL177W-A		845,	1328,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the uncharacterized gene YIL177C
chrIX	8792	9155	8792	9155	-	PAU14	YIL176C		8792,	9155,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions  identical to Pau1p
chrIX	11491	16141	11491	16141	+	VTH1	YIL173W		11491,	16141,	Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
chrIX	16783	18553	16783	18553	-	IMA3	YIL172C		16783,	18553,	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides  member of IMA isomaltase family  not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose
chrIX	18259	18712	18259	18712	+	YIL171W-A	YIL171W-A		18259,	18712,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	23118	26106	23118	26106	-	YIL169C	YIL169C		23118,	26106,	Putative protein of unknown function  serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase  transcript is induced in both high and low pH environments  YIL169C is a non-essential gene
chrIX	30937	32566	30937	32566	-	YIL166C	YIL166C		30937,	32566,	Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily  mRNA expression is elevated by sulfur limitation  YIL166C is a non-essential gene
chrIX	33717	34077	33717	34077	-	YIL165C	YIL165C		33717,	34077,	Putative protein of unknown function  mutant exhibits mitophagy defects  in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene
chrIX	34086	34686	34086	34686	-	NIT1	YIL164C		34086,	34686,	Nitrilase, member of the nitrilase branch of the nitrilase superfamily  in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
chrIX	36898	37252	36898	37252	-	YIL163C	YIL163C		36898,	37252,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	37384	38983	37384	38983	+	SUC2	YIL162W		37384,	38983,	Invertase, sucrose hydrolyzing enzyme  a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
chrIX	39432	40140	39432	40140	+	YIL161W	YIL161W		39432,	40140,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  mRNA is enriched in Scp160p-associated mRNPs  YIL161W is a non-essential gene
chrIX	40190	41444	40190	41444	-	POT1	YIL160C		40190,	41444,	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
chrIX	41824	45952	41824	45952	+	BNR1	YIL159W		41824,	45952,	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
chrIX	46200	46815	46200	46815	+	AIM20	YIL158W		46200,	46815,	Putative protein of unknown function  overexpression causes a cell cycle delay or arrest  green fluorescent protein (GFP)-fusion protein localizes to the vacuole  null mutant displays elevated frequency of mitochondrial genome loss
chrIX	46948	47542	46948	47542	-	COA1	YIL157C		46948,	47542,	Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV)  interacts with complex IV assembly factor Shy1p during the early stages of assembly
chrIX	47291	47693	47291	47693	+	YIL156W-A	YIL156W-A		47291,	47693,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	47689	47973	47689	47973	+	YIL156W-B	YIL156W-B		47689,47760,	47698,47973,	Putative protein of unknown function, originally identified based on homology to Ashbya gossypii and other related yeasts
chrIX	48090	51306	48090	51306	+	UBP7	YIL156W		48090,	51306,	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
chrIX	51758	53708	51758	53708	-	GUT2	YIL155C		51758,	53708,	Mitochondrial glycerol-3-phosphate dehydrogenase  expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
chrIX	53980	55021	53980	55021	-	IMP2'	YIL154C		53980,	55021,	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
chrIX	55197	56379	55197	56379	+	RRD1	YIL153W		55197,	56379,	Peptidyl-prolyl cis/trans-isomerase  activator of the phosphotyrosyl phosphatase activity of PP2A  involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair  required for rapid reduction of Sgs1p levels in response to rapamycin  subunit of the Tap42p-Sit4p-Rrd1p complex
chrIX	56544	57252	56544	57252	+	YIL152W	YIL152W		56544,	57252,	Putative protein of unknown function
chrIX	57337	60694	57337	60694	-	YIL151C	YIL151C		57337,	60694,	Putative protein of unknown function, predicted to contain a PINc domain
chrIX	61012	62728	61012	62728	-	MCM10	YIL150C		61012,	62728,	Essential chromatin-associated protein involved in the initiation of DNA replication  required for the association of the MCM2-7 complex with replication origins
chrIX	63027	68067	63027	68067	-	MLP2	YIL149C		63027,	68067,	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior  involved in the Tel1p pathway that controls telomere length
chrIX	68707	69528	68707	69528	+	RPL40A	YIL148W		68707,69149,	68715,69528,	Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40  ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
chrIX	69790	73453	69790	73453	-	SLN1	YIL147C		69790,	73453,	Histidine kinase osmosensor that regulates a MAP kinase cascade  transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
chrIX	74183	75773	74183	75773	-	ATG32	YIL146C		74183,	75773,	Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation
chrIX	76353	77283	76353	77283	-	PAN6	YIL145C		76353,	77283,	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
chrIX	78073	80149	78073	80149	+	TID3	YIL144W		78073,	80149,	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p)  conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
chrIX	80509	83041	80509	83041	-	SSL2	YIL143C		80509,	83041,	Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA  involved in DNA repair  homolog of human ERCC3
chrIX	83207	83540	83207	83540	-	YIL142C-A	YIL142C-A		83207,	83540,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	83301	84885	83301	84885	+	CCT2	YIL142W		83301,	84885,	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
chrIX	85052	85442	85052	85442	+	YIL141W	YIL141W		85052,	85442,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	85365	87837	85365	87837	+	AXL2	YIL140W		85365,	87837,	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck  glycosylated by Pmt4p  potential Cdc28p substrate
chrIX	87978	88716	87978	88716	-	REV7	YIL139C		87978,	88716,	Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair  required for mutagenesis induced by DNA damage  involved in double-strand break repair
chrIX	89229	89715	89229	89715	-	TPM2	YIL138C		89229,	89715,	Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles  appears to have distinct and also overlapping functions with Tpm1p
chrIX	89947	92788	89947	92788	-	TMA108	YIL137C		89947,	92788,	Protein that associates with ribosomes and is involved in ribosome biogenesis  putative metalloprotease
chrIX	93618	94800	93618	94800	+	OM45	YIL136W		93618,	94800,	Protein of unknown function, major constituent of the mitochondrial outer membrane  located on the outer (cytosolic) face of the outer membrane
chrIX	95064	96375	95064	96375	-	VHS2	YIL135C		95064,	96375,	Cytoplasmic protein of unknown function  identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression  similar to Mlf3p
chrIX	96521	96725	96521	96725	-	YIL134C-A	YIL134C-A		96521,	96725,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrIX	97394	98330	97394	98330	+	FLX1	YIL134W		97394,	98330,	Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane
chrIX	98526	99416	98526	99416	-	RPL16A	YIL133C		98526,99385,	99095,99416,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA  has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins  transcriptionally regulated by Rap1p
chrIX	99859	100501	99859	100501	-	CSM2	YIL132C		99859,	100501,	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis
chrIX	100780	102235	100780	102235	-	FKH1	YIL131C		100780,	102235,	Forkhead family transcription factor with a minor role in the expression of G2/M phase genes  negatively regulates transcriptional elongation  positive role in chromatin silencing at HML and HMR  regulates donor preference during switching
chrIX	102781	105676	102781	105676	+	ASG1	YIL130W		102781,	105676,	Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response  null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
chrIX	106106	113237	106106	113237	-	TAO3	YIL129C		106106,	113237,	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
chrIX	113805	116904	113805	116904	+	MET18	YIL128W		113805,	116904,	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription  involved in telomere maintenance
chrIX	117023	117644	117023	117644	-	RRT14	YIL127C		117023,	117644,	Putative protein of unknown function  identified in a screen for mutants with decreased levels of rDNA transcription  green fluorescent protein (GFP)-fusion protein localizes to the nucleolus  predicted to be involved in ribosome biogenesis
chrIX	117991	122071	117991	122071	+	STH1	YIL126W		117991,	122071,	ATPase component of the RSC chromatin remodeling complex  required for expression of early meiotic genes  essential helicase-related protein homologous to Snf2p
chrIX	122688	125733	122688	125733	+	KGD1	YIL125W		122688,	125733,	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
chrIX	126203	127097	126203	127097	+	AYR1	YIL124W		126203,	127097,	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane  involved in phosphatidic acid biosynthesis  required for spore germination  capable of metabolizing steroid hormones
chrIX	128150	129581	128150	129581	+	SIM1	YIL123W		128150,	129581,	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
chrIX	130609	131665	130609	131665	+	POG1	YIL122W		130609,	131665,	Nuclear chromatin-associated protein of unknown function  overexpression promotes recovery from pheromone induced arrest and suppresses the stress sensitivity caused by a mutation in the E3 ubiquitin ligase Rsp5p  binds upstream of BAR1 and cell cycle-related genes  potential Cdc28p substrate  SBF regulated
chrIX	132243	133872	132243	133872	+	QDR2	YIL121W		132243,	133872,	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin  may have a role in potassium uptake
chrIX	134416	136108	134416	136108	+	QDR1	YIL120W		134416,	136108,	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
chrIX	136653	137877	136653	137877	-	RPI1	YIL119C		136653,	137877,	Putative transcriptional regulator  overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
chrIX	139751	140447	139751	140447	+	RHO3	YIL118W		139751,	140447,	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity  GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
chrIX	140612	141569	140612	141569	-	PRM5	YIL117C		140612,	141569,	Pheromone-regulated protein, predicted to have 1 transmembrane segment  induced during cell integrity signaling
chrIX	142927	144085	142927	144085	+	HIS5	YIL116W		142927,	144085,	Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis  responsive to general control of amino acid biosynthesis  mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
chrIX	144267	144639	144267	144639	+	YIL115W-A	YIL115W-A		144267,	144639,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene NUP159/YIL115C
chrIX	144326	148709	144326	148709	-	NUP159	YIL115C		144326,	148709,	Nucleoporin, subunit of the Nup82 subcomplex of the nuclear pore  part of the nuclear pore that is found exclusively on the cytoplasmic side  required for mRNA export  regulates ADP release from the ATP-dependent RNA helicase Dbp5p
chrIX	149142	149988	149142	149988	-	POR2	YIL114C		149142,	149988,	Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
chrIX	150558	151188	150558	151188	+	SDP1	YIL113W		150558,	151188,	Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
chrIX	151594	154846	151594	154846	+	HOS4	YIL112W		151594,	154846,	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity  potential Cdc28p substrate
chrIX	155221	155765	155221	155765	+	COX5B	YIL111W		155221,155310,	155222,155765,	Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
chrIX	156044	157178	156044	157178	+	HPM1	YIL110W		156044,	157178,	AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p  seven beta-strand MTase family member  null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance
chrIX	157384	160165	157384	160165	-	SEC24	YIL109C		157384,	160165,	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport  homologous to Sfb2p and Sfb3p
chrIX	160886	162977	160886	162977	+	YIL108W	YIL108W		160886,	162977,	Putative metalloprotease
chrIX	163277	165761	163277	165761	-	PFK26	YIL107C		163277,	165761,	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate  has negligible fructose-2,6-bisphosphatase activity  transcriptional regulation involves protein kinase A
chrIX	166414	167444	166414	167444	+	MOB1	YIL106W		166414,166519,	166434,167444,	Component of the mitotic exit network  associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase  required for cytokinesis and cell separation  component of the CCR4 transcriptional complex
chrIX	167580	169641	167580	169641	-	SLM1	YIL105C		167580,	169641,	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p  acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress  phosphorylated by the TORC2 complex
chrIX	167663	167804	167663	167804	+	YIL105W-A	YIL105W-A		167663,	167804,	Dubious open reading frame  completely overlaps the verified gene SLM1  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrIX	169981	171505	169981	171505	-	SHQ1	YIL104C		169981,	171505,	Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p  homology with known Hsp90p cochaperones
chrIX	171750	173028	171750	173028	+	DPH1	YIL103W		171750,	173028,	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p)  may act in a complex with Dph2p and Kti11p
chrIX	173364	173592	173364	173592	-	YIL102C-A	YIL102C-A		173364,	173592,	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
chrIX	174581	174887	174581	174887	-	YIL102C	YIL102C		174581,	174887,	Putative protein of unknown function
chrIX	175306	177250	175306	177250	-	XBP1	YIL101C		175306,	177250,	Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2  expression is induced by stress or starvation during mitosis, and late in meiosis  member of the Swi4p/Mbp1p family  potential Cdc28p substrate
chrIX	177342	177681	177342	177681	-	YIL100C-A	YIL100C-A		177342,	177681,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	177372	177726	177372	177726	+	YIL100W	YIL100W		177372,	177726,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the dubious ORF YIL100C-A
chrIX	178003	179653	178003	179653	+	SGA1	YIL099W		178003,	179653,	Intracellular sporulation-specific glucoamylase involved in glycogen degradation  induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
chrIX	179771	180239	179771	180239	-	FMC1	YIL098C		179771,	180239,	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase  null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
chrIX	180426	181977	180426	181977	+	FYV10	YIL097W		180426,	181977,	Protein of unknown function, required for survival upon exposure to K1 killer toxin  involved in proteasome-dependent catabolite inactivation of FBPase  contains CTLH domain  plays role in anti-apoptosis
chrIX	182116	183127	182116	183127	-	YIL096C	YIL096C		182116,	183127,	Putative protein of unknown function  associates with precursors of the 60S ribosomal subunit  predicted to be involved in ribosome biogenesis
chrIX	183936	186369	183936	186369	+	PRK1	YIL095W		183936,	186369,	Protein serine/threonine kinase  regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
chrIX	186516	187632	186516	187632	-	LYS12	YIL094C		186516,	187632,	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
chrIX	187989	188784	187989	188784	-	RSM25	YIL093C		187989,	188784,	Mitochondrial ribosomal protein of the small subunit
chrIX	189065	190967	189065	190967	+	YIL092W	YIL092W		189065,	190967,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
chrIX	191029	193195	191029	193195	-	UTP25	YIL091C		191029,	193195,	Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis  contains a DEAD-box RNA helicase-like motif
chrIX	193594	195070	193594	195070	+	ICE2	YIL090W		193594,	195070,	Integral ER membrane protein with type-III transmembrane domains  mutations cause defects in cortical ER morphology in both the mother and daughter cells
chrIX	195598	196216	195598	196216	+	YIL089W	YIL089W		195598,	196216,	Protein of unknown function found in the ER and vacuole lumen  overexpression of YIL089W affects endocytic protein trafficking
chrIX	197930	199403	197930	199403	-	AVT7	YIL088C		197930,	199403,	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
chrIX	199645	200119	199645	200119	-	AIM19	YIL087C		199645,	200119,	Putative protein of unknown function  the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies  null mutant displays reduced respiratory growth
chrIX	200152	200461	200152	200461	-	YIL086C	YIL086C		200152,	200461,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	200489	202043	200489	202043	-	KTR7	YIL085C		200489,	202043,	Putative mannosyltransferase involved in protein glycosylation  member of the KRE2/MNT1 mannosyltransferase family
chrIX	202275	203259	202275	203259	-	SDS3	YIL084C		202275,	203259,	Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation  cells defective in SDS3 display pleiotropic phenotypes
chrIX	203555	204653	203555	204653	-	CAB2	YIL083C		203555,	204653,	Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate  null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
chrIX	205634	210132	205634	210132	+	YIL082W-A	YIL082W-A		205634,206486,	206485,210132,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrIX	205634	206507	205634	206507	+	YIL082W	YIL082W		205634,	206507,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrIX	210922	212005	210922	212005	-	AIR1	YIL079C		210922,	212005,	Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex  stimulates the poly(A) polymerase activity of Pap2p in vitro  functionally redundant with Air2p
chrIX	212498	214703	212498	214703	+	THS1	YIL078W		212498,	214703,	Threonyl-tRNA synthetase, essential cytoplasmic protein
chrIX	214990	215953	214990	215953	-	YIL077C	YIL077C		214990,	215953,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
chrIX	216657	217548	216657	217548	+	SEC28	YIL076W		216657,	217548,	Epsilon-COP subunit of the coatomer  regulates retrograde Golgi-to-ER protein traffic  stabilizes Cop1p, the alpha-COP and the coatomer complex  non-essential for cell growth
chrIX	217862	220700	217862	220700	-	RPN2	YIL075C		217862,	220700,	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
chrIX	221080	222490	221080	222490	-	SER33	YIL074C		221080,	222490,	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis  isozyme of Ser3p
chrIX	222936	225954	222936	225954	-	SPO22	YIL073C		222936,225899,	225809,225954,	Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis  induced early in meiosis
chrIX	226601	228419	226601	228419	+	HOP1	YIL072W		226601,	228419,	Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex  required for homologous chromosome synapsis and chiasma formation
chrIX	228549	229026	228549	229026	+	YIL071W-A	YIL071W-A		228549,	229026,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	228659	229994	228659	229994	-	PCI8	YIL071C		228659,	229994,	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
chrIX	230271	231072	230271	231072	-	MAM33	YIL070C		230271,	231072,	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation  related to the human complement receptor gC1q-R
chrIX	231552	232369	231552	232369	-	RPS24B	YIL069C		231552,232366,	231957,232369,	Protein component of the small (40S) ribosomal subunit  identical to Rps24Ap and has similarity to rat S24 ribosomal protein
chrIX	233012	233396	233012	233396	+	YIL068W-A	YIL068W-A		233012,	233396,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	233056	235474	233056	235474	-	SEC6	YIL068C		233056,	235474,	Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis  dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly
chrIX	235723	237760	235723	237760	-	YIL067C	YIL067C		235723,	237760,	Uncharacterized protein of unknown function
chrIX	237365	237809	237365	237809	+	YIL066W-A	YIL066W-A		237365,	237809,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	238098	240708	238098	240708	-	RNR3	YIL066C		238098,	240708,	Minor isoform of the large subunit of ribonucleotide-diphosphate reductase  the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
chrIX	241307	241775	241307	241775	-	FIS1	YIL065C		241307,	241775,	Protein involved in mitochondrial membrane fission and peroxisome abundance  required for localization of Dnm1p and Mdv1p during mitochondrial division  mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
chrIX	241942	242716	241942	242716	+	SEE1	YIL064W		241942,	242716,	Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p)  sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family  role in vesicular transport
chrIX	242760	243744	242760	243744	-	YRB2	YIL063C		242760,	243744,	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle  involved in nuclear protein export  contains Ran Binding Domain and FxFG repeats  interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p  is not essential
chrIX	243997	244462	243997	244462	-	ARC15	YIL062C		243997,	244462,	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches  has mRNA binding activity
chrIX	244656	245559	244656	245559	-	SNP1	YIL061C		244656,	245559,	Component of U1 snRNP required for mRNA splicing via spliceosome  substrate of the arginine methyltransferase Hmt1p  may interact with poly(A) polymerase to regulate polyadenylation  homolog of human U1 70K protein
chrIX	246391	246826	246391	246826	+	YIL060W	YIL060W		246391,	246826,	Putative protein of unknown function  mutant accumulates less glycogen than does wild type  null mutation results in a decrease in plasma membrane electron transport  YIL060W is not an essential gene
chrIX	246549	246915	246549	246915	-	YIL059C	YIL059C		246549,	246915,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YIL060W
chrIX	246913	247198	246913	247198	+	YIL058W	YIL058W		246913,	247198,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	247901	248396	247901	248396	-	RGI2	YIL057C		247901,	248396,	Protein of unknown function involved in energy metabolism under respiratory conditions  expression induced under carbon limitation and repressed under high glucose
chrIX	249990	251913	249990	251913	+	VHR1	YIL056W		249990,	251913,	Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
chrIX	252041	253925	252041	253925	-	YIL055C	YIL055C		252041,	253925,	Putative protein of unknown function
chrIX	254542	254860	254542	254860	+	YIL054W	YIL054W		254542,	254860,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIX	255114	255867	255114	255867	+	RHR2	YIL053W		255114,	255867,	Constitutively expressed isoform of DL-glycerol-3-phosphatase  involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
chrIX	256225	257063	256225	257063	-	RPL34B	YIL052C		256225,257026,	256554,257063,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
chrIX	257842	258280	257842	258280	-	MMF1	YIL051C		257842,	258280,	Mitochondrial protein required for transamination of isoleucine but not of valine or leucine  may regulate specificity of branched-chain transaminases Bat1p and Bat2p  interacts genetically with mitochondrial ribosomal protein genes
chrIX	258912	259770	258912	259770	+	PCL7	YIL050W		258912,	259770,	Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p  involved in glycogen metabolism, expression is cell-cycle regulated
chrIX	260157	260919	260157	260919	+	DFG10	YIL049W		260157,	260919,	Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation  involved in filamentous growth  mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation)
chrIX	261436	264892	261436	264892	+	NEO1	YIL048W		261436,	264892,	Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis  localizes to endosomes and the Golgi aparatus
chrIX	265098	265467	265098	265467	-	YIL047C-A	YIL047C-A		265098,	265467,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	265114	267823	265114	267823	-	SYG1	YIL047C		265114,	267823,	Plasma membrane protein of unknown function  truncation and overexpression suppresses lethality of G-alpha protein deficiency
chrIX	268308	268473	268308	268473	+	YIL046W-A	YIL046W-A		268308,	268473,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrIX	268650	270573	268650	270573	+	MET30	YIL046W		268650,	270573,	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex  interacts with and regulates Met4p, localizes within the nucleus
chrIX	271160	272777	271160	272777	+	PIG2	YIL045W		271160,	272777,	Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
chrIX	272949	273846	272949	273846	-	AGE2	YIL044C		272949,	273846,	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport  contains C2C2H2 cysteine/histidine motif
chrIX	274071	274926	274071	274926	-	CBR1	YIL043C		274071,	274926,	Microsomal cytochrome b reductase, not essential for viability  also detected in mitochondria  mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
chrIX	275107	276292	275107	276292	-	PKP1	YIL042C		275107,	276292,	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit  acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
chrIX	276524	277505	276524	277505	+	GVP36	YIL041W		276524,	277505,	BAR domain-containing protein that localizes to both early and late Golgi vesicles  required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
chrIX	277722	278139	277722	278139	+	APQ12	YIL040W		277722,	278139,	Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus  exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
chrIX	278425	279847	278425	279847	+	TED1	YIL039W		278425,	279847,	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER  deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
chrIX	280141	282652	280141	282652	-	NOT3	YIL038C		280141,	282652,	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
chrIX	283028	284999	283028	284999	-	PRM2	YIL037C		283028,	284999,	Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain  regulated by Ste12p  required for efficient nuclear fusion
chrIX	285665	287429	285665	287429	+	CST6	YIL036W		285665,	287429,	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes  involved in utilization of non-optimal carbon sources and chromosome stability
chrIX	287789	288908	287789	288908	-	CKA1	YIL035C		287789,	288908,	Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation  CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
chrIX	289225	290089	289225	290089	-	CAP2	YIL034C		289225,	290089,	Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization  localized predominantly to cortical actin patches
chrIX	290418	291669	290418	291669	-	BCY1	YIL033C		290418,	291669,	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
chrIX	291960	292317	291960	292317	-	YIL032C	YIL032C		291960,	292317,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIX	292632	295737	292632	295737	+	ULP2	YIL031W		292632,	295737,	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects  potential Cdc28p substrate
chrIX	295564	295903	295564	295903	+	YIL030W-A	YIL030W-A		295564,	295903,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YIL031W.
chrIX	296049	300009	296049	300009	-	SSM4	YIL030C		296049,	300009,	Ubiquitin-protein ligase involved in ER-associated protein degradation  located in the ER/nuclear envelope  ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
chrIX	299734	300106	299734	300106	+	YIL029W-A	YIL029W-A		299734,	300106,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	300828	301257	300828	301257	-	YIL029C	YIL029C		300828,	301257,	Putative protein of unknown function  deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
chrIX	302099	302498	302099	302498	+	YIL028W	YIL028W		302099,	302498,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIX	303678	304104	303678	304104	-	KRE27	YIL027C		303678,	304104,	Member of a transmembrane complex required for efficient folding of proteins in the ER  null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance
chrIX	304476	307929	304476	307929	-	IRR1	YIL026C		304476,	307929,	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
chrIX	308200	308575	308200	308575	-	YIL025C	YIL025C		308200,	308575,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	308601	309171	308601	309171	-	YIL024C	YIL024C		308601,	309171,	Putative protein of unknown function  non-essential gene  expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
chrIX	309385	310426	309385	310426	-	YKE4	YIL023C		309385,	310426,	Zinc transporter  localizes to the ER  null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol  ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
chrIX	311164	312460	311164	312460	+	TIM44	YIL022W		311164,	312460,	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
chrIX	312904	313861	312904	313861	+	RPB3	YIL021W		312904,	313861,	RNA polymerase II third largest subunit B44, part of central core  similar to prokaryotic alpha subunit
chrIX	313198	313468	313198	313468	-	YIL021C-A	YIL021C-A		313198,	313468,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps verified gene RPB3/YIL021W  identified by gene-trapping, expression analysis, and genome-wide homology searching
chrIX	313712	314051	313712	314051	-	YIL020C-A	YIL020C-A		313712,	314051,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	314034	314820	314034	314820	-	HIS6	YIL020C		314034,	314820,	Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis  mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
chrIX	315092	316133	315092	316133	+	FAF1	YIL019W		315092,	316133,	Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
chrIX	316767	317932	316767	317932	+	RPL2B	YIL018W		316767,317171,	316771,317932,	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins  expression is upregulated at low temperatures
chrIX	318199	320965	318199	320965	-	VID28	YIL017C		318199,	320965,	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase)  localized to the nucleus and the cytoplasm
chrIX	321453	321933	321453	321933	+	SNL1	YIL016W		321453,	321933,	Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding  has similarity to the mammalian BAG-1 protein
chrIX	322341	324105	322341	324105	+	BAR1	YIL015W		322341,	324105,	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
chrIX	325211	325526	325211	325526	-	YIL014C-A	YIL014C-A		325211,	325526,	Putative protein of unknown function
chrIX	326102	327995	326102	327995	+	MNT3	YIL014W		326102,	327995,	Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
chrIX	328206	332442	328206	332442	-	PDR11	YIL013C		328206,	332442,	ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance  mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p  required for anaerobic growth
chrIX	333010	333352	333010	333352	+	YIL012W	YIL012W		333010,	333352,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrIX	333726	334536	333726	334536	+	TIR3	YIL011W		333726,	334536,	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins  expressed under anaerobic conditions and required for anaerobic growth
chrIX	334881	335529	334881	335529	+	DOT5	YIL010W		334881,	335529,	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
chrIX	335665	336212	335665	336212	-	EST3	YIL009C-A		335665,335936,	335935,336212,	Component of the telomerase holoenzyme, involved in telomere replication
chrIX	339343	341428	339343	341428	+	FAA3	YIL009W		339343,	341428,	Long chain fatty acyl-CoA synthetase, activates imported fatty acids  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
chrIX	342535	342835	342535	342835	+	URM1	YIL008W		342535,	342835,	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs  receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA  also functions as a protein tag with roles in nutrient sensing and oxidative stress response
chrIX	342993	343656	342993	343656	-	NAS2	YIL007C		342993,	343656,	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP)  similar to mammalian proteasomal modulator subunit  non-essential gene  interacts with Rpn4p
chrIX	344061	345183	344061	345183	+	YIA6	YIL006W		344061,	345183,	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6)  member of the mitochondrial carrier subfamily  disputed role as a pyruvate transporter  has putative mouse and human orthologs
chrIX	345691	347797	345691	347797	+	EPS1	YIL005W		345691,	347797,	ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins  has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
chrIX	347945	348505	347945	348505	-	BET1	YIL004C		347945,348494,	348363,348505,	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex  v-SNARE with similarity to synaptobrevins
chrIX	349121	350003	349121	350003	+	CFD1	YIL003W		349121,	350003,	Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm  forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
chrIX	350300	350510	350300	350510	+	YIL002W-A	YIL002W-A		350300,	350510,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrIX	350590	353431	350590	353431	-	INP51	YIL002C		350590,	353431,	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis  null mutation confers cold-tolerant growth
chrIX	353939	355481	353939	355481	+	YIL001W	YIL001W		353939,	355481,	Putative protein of unknown function  contains a BTB/POZ domain which generally function in protein interactions  deletion slightly improved competitive fitness in rich media  GFP-tagged protein is localized to the cytoplasm
chrIX	356142	356895	356142	356895	-	SGN1	YIR001C		356142,	356895,	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM)  may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
chrIX	357414	360396	357414	360396	-	MPH1	YIR002C		357414,	360396,	Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p  mutations confer a mutator phenotype
chrIX	360884	362924	360884	362924	+	AIM21	YIR003W		360884,	362924,	Protein of unknown function involved in mitochondrial migration along actin filament  may interact with ribosomes  GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton
chrIX	363220	364519	363220	364519	+	DJP1	YIR004W		363220,	364519,	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
chrIX	364888	365335	364888	365335	+	IST3	YIR005W		364888,	365335,	Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly  interacts with Rds3p and is required for Mer1p-activated splicing
chrIX	365465	369908	365465	369908	-	PAN1	YIR006C		365465,	369908,	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex  promotes protein-protein interactions essential for endocytosis  previously thought to be a subunit of poly(A) ribonuclease
chrIX	370703	372998	370703	372998	+	YIR007W	YIR007W		370703,	372998,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YIR007W is a non-essential gene
chrIX	373076	374306	373076	374306	-	PRI1	YIR008C		373076,	374306,	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
chrIX	374524	374860	374524	374860	+	MSL1	YIR009W		374524,	374860,	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding  does not contain the conserved C-terminal RNA binding domain found in other family members
chrIX	375430	377161	375430	377161	+	DSN1	YIR010W		375430,	377161,	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules  important for chromosome segregation
chrIX	377286	378246	377286	378246	-	STS1	YIR011C		377286,	378246,	Protein required for localizing proteasomes to the nucleus  interacts with the karyopherin Srp1p  involved in ubiquitin-mediated protein degradation
chrIX	378485	379781	378485	379781	+	SQT1	YIR012W		378485,	379781,	Essential protein involved in a late step of 60S ribosomal subunit assembly or modification  contains multiple WD repeats  interacts with Qsr1p in a two-hybrid assay
chrIX	380018	380384	380018	380384	-	GAT4	YIR013C		380018,	380384,	Protein containing GATA family zinc finger motifs
chrIX	381085	381814	381085	381814	+	YIR014W	YIR014W		381085,	381814,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole  expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p  YIR014W is a non-essential gene
chrIX	381947	382382	381947	382382	+	RPR2	YIR015W		381947,	382382,	Subunit of nuclear RNase P  nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs  not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits
chrIX	382627	383425	382627	383425	+	YIR016W	YIR016W		382627,	383425,	Putative protein of unknown function  expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p  overexpression causes a cell cycle delay or arrest  YIR016W is a non-essential gene
chrIX	383555	384119	383555	384119	-	MET28	YIR017C		383555,	384119,	Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
chrIX	383565	384165	383565	384165	+	YIR017W-A	YIR017W-A		383565,	384165,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	384608	385346	384608	385346	+	YAP5	YIR018W		384608,	385346,	Basic leucine zipper (bZIP) transcription factor
chrIX	385563	385701	385563	385701	-	YIR018C-A	YIR018C-A		385563,	385701,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrIX	389571	393675	389571	393675	-	MUC1	YIR019C		389571,	393675,	GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms  transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
chrIX	394254	394557	394254	394557	-	YIR020C	YIR020C		394254,	394557,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	394916	395159	394916	395159	+	YIR020W-A	YIR020W-A		394916,	395159,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrIX	397214	397949	397214	397949	-	YIR020C-B	YIR020C-B		397214,	397949,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF MRS1
chrIX	397293	398385	397293	398385	+	MRS1	YIR021W		397293,	398385,	Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1)  forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
chrIX	398513	398726	398513	398726	+	YIR021W-A	YIR021W-A		398513,	398726,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrIX	398732	399236	398732	399236	+	SEC11	YIR022W		398732,	399236,	18kDa catalytic subunit of the Signal Peptidase Complex (SPC  Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
chrIX	399776	402689	399776	402689	+	DAL81	YIR023W		399776,	402689,	Positive regulator of genes in multiple nitrogen degradation pathways  contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
chrIX	402382	402706	402382	402706	-	YIR023C-A	YIR023C-A		402382,	402706,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	402840	403491	402840	403491	-	YIR024C	YIR024C		402840,	403491,	Protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  interacts with Arh1p, a mitochondrial oxidoreductase  deletion mutant has a respiratory growth defect
chrIX	403658	404765	403658	404765	+	MND2	YIR025W		403658,	404765,	Subunit of the anaphase-promoting complex (APC)  necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase
chrIX	404872	405967	404872	405967	-	YVH1	YIR026C		404872,	405967,	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation  mutants are defective in 60S ribosome assembly  member of the dual-specificity family of protein phosphatases
chrIX	406259	407642	406259	407642	-	DAL1	YIR027C		406259,	407642,	Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation  expression sensitive to nitrogen catabolite repression
chrIX	408467	410375	408467	410375	+	DAL4	YIR028W		408467,	410375,	Allantoin permease  expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
chrIX	410806	411838	410806	411838	+	DAL2	YIR029W		410806,	411838,	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation  expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
chrIX	412035	412770	412035	412770	-	DCG1	YIR030C		412035,	412770,	Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p  contains transmembrane domain
chrIX	412898	413282	412898	413282	+	YIR030W-A	YIR030W-A		412898,	413282,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	413014	414679	413014	414679	-	DAL7	YIR031C		413014,	414679,	Malate synthase, role in allantoin degradation unknown  expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
chrIX	415029	415617	415029	415617	-	DAL3	YIR032C		415029,	415617,	Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation  expression sensitive to nitrogen catabolite repression
chrIX	416123	419465	416123	419465	+	MGA2	YIR033W		416123,	419465,	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p  inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
chrIX	419614	420736	419614	420736	-	LYS1	YIR034C		419614,	420736,	Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway  also has mRNA binding activity
chrIX	421025	421790	421025	421790	-	YIR035C	YIR035C		421025,	421790,	Putative cytoplasmic protein of unknown function
chrIX	422073	422865	422073	422865	-	IRC24	YIR036C		422073,	422865,	Putative benzil reductase (GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS  sequence similarity with short-chain dehydrogenase/reductases  null mutant has increased spontaneous Rad52p foci
chrIX	422634	423036	422634	423036	+	YIR036W-A	YIR036W-A		422634,	423036,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrIX	423127	423619	423127	423619	+	HYR1	YIR037W		423127,	423619,	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
chrIX	423808	424513	423808	424513	-	GTT1	YIR038C		423808,	424513,	ER associated glutathione S-transferase capable of homodimerization  expression induced during the diauxic shift and throughout stationary phase  functional overlap with Gtt2p, Grx1p, and Grx2p
chrIX	430497	432111	430497	432111	-	YPS6	YIR039C		430497,	432111,	Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance
chrIX	433388	433721	433388	433721	-	YIR040C	YIR040C		433388,	433721,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrIX	433928	434303	433928	434303	+	PAU15	YIR041W		433928,	434303,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
chrIX	435272	435983	435272	435983	-	YIR042C	YIR042C		435272,	435983,	Putative protein of unknown function  YIR042C is a non-essential gene
chrM	3951	4338	3951	4338	+	Q0010	Q0010		3951,	4338,	Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF Q0017
chrM	4253	4415	4253	4415	+	Q0017	Q0017		4253,	4415,	Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF Q0010
chrM	11666	11957	11666	11957	+	Q0032	Q0032		11666,	11957,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrM	13817	26701	13817	26701	+	COX1	Q0045		13817,16434,18953,20507,21994,23611,25317,26228,	13986,16470,18991,20984,22246,23746,25342,26701,	Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  one of three mitochondrially-encoded subunits
chrM	13817	23167	13817	23167	+	AI5_ALPHA	Q0070		13817,16434,18953,20507,21994,	13986,16470,18991,20984,23167,	Endonuclease I-SceIV, involved in intron mobility  encoded by a mobile group I intron within the mitochondrial COX1 gene
chrM	13817	21935	13817	21935	+	AI4	Q0065		13817,16434,18953,20507,	13986,16470,18991,21935,	Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene  intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity
chrM	13817	19996	13817	19996	+	AI3	Q0060		13817,16434,18953,	13986,16470,19996,	Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene
chrM	13817	18830	13817	18830	+	AI2	Q0055		13817,16434,	13986,18830,	Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene
chrM	13817	16322	13817	16322	+	AI1	Q0050		13817,	16322,	Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene
chrM	24155	25255	24155	25255	+	AI5_BETA	Q0075		24155,24905,	24870,25255,	Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene  translational initiation codon is predicted to be ATA rather than ATG
chrM	27665	27812	27665	27812	+	ATP8	Q0080		27665,	27812,	Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome  ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase
chrM	28486	29266	28486	29266	+	ATP6	Q0085		28486,	29266,	Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase  translation is specifically activated by Atp22p  ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase
chrM	30873	31014	30873	31014	+	Q0092	Q0092		30873,	31014,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrM	36539	43647	36539	43647	+	COB	Q0105		36539,37722,39140,40840,42507,43296,	36954,37736,39217,41090,42558,43647,	Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p
chrM	36539	42251	36539	42251	+	BI4	Q0120		36539,37722,39140,40840,	36954,37736,39217,42251,	Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene  encoded by both exon and intron sequences of partially processed COB mRNA
chrM	36539	40265	36539	40265	+	BI3	Q0115		36539,37722,39140,	36954,37736,40265,	Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene  encoded by both exon and intron sequences of partially processed COB mRNA
chrM	36539	38579	36539	38579	+	BI2	Q0110		36539,37722,	36954,38579,	Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA
chrM	46722	46953	46722	46953	+	OLI1	Q0130		46722,	46953,	F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome  mutation confers oligomycin resistance  expression is specifically dependent on the nuclear genes AEP1 and AEP2
chrM	48900	50097	48900	50097	+	VAR1	Q0140		48900,	50097,	Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded  polymorphic in different strains due to variation in number of AAT (asparagine) codons  translated near the mitochondrial inner membrane
chrM	51051	51228	51051	51228	+	Q0142	Q0142		51051,	51228,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps dubious open reading frame Q0143
chrM	51276	51429	51276	51429	+	Q0143	Q0143		51276,	51429,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrM	54108	54438	54108	54438	+	Q0144	Q0144		54108,	54438,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrM	61021	61729	61021	61729	+	SCEI	Q0160		61021,	61729,	I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene  mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene
chrM	65769	66174	65769	66174	+	Q0182	Q0182		65769,	66174,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrM	73757	74513	73757	74513	+	COX2	Q0250		73757,	74513,	Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  one of three mitochondrially-encoded subunits
chrM	74494	75984	74494	75984	+	Q0255	Q0255		74494,75662,75903,	75622,75872,75984,	Maturase-like protein
chrM	79212	80022	79212	80022	+	COX3	Q0275		79212,	80022,	Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  one of three mitochondrially-encoded subunits
chrM	85553	85709	85553	85709	+	Q0297	Q0297		85553,	85709,	Dubious open reading frame of the mitochondrial genome  unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene RPM1
chrV	263	4097	263	4097	-	YEL077C	YEL077C		263,	4097,	Helicase-like protein encoded within the telomeric Y' element
chrV	629	1112	629	1112	+	YEL077W-A	YEL077W-A		629,	1112,	Dubious open reading frame, unlike to encode a functional protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrV	4184	5114	4184	5114	-	YEL076C-A	YEL076C-A		4184,4601,	4322,5114,	Putative protein of unknown function
chrV	4463	5114	4463	5114	-	YEL076C	YEL076C		4463,	5114,	Putative protein of unknown function
chrV	4869	5481	4869	5481	+	YEL075W-A	YEL075W-A		4869,	5481,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	5344	5713	5344	5713	-	YEL075C	YEL075C		5344,	5713,	Putative protein of unknown function
chrV	6125	6464	6125	6464	+	YEL074W	YEL074W		6125,	6464,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components.
chrV	7229	7553	7229	7553	-	YEL073C	YEL073C		7229,	7553,	Putative protein of unknown function  located adjacent to ARS503 and the telomere on the left arm of chromosome V  regulated by inositol/choline
chrV	13719	14415	13719	14415	+	RMD6	YEL072W		13719,	14415,	Protein required for sporulation
chrV	16354	17845	16354	17845	+	DLD3	YEL071W		16354,	17845,	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
chrV	19588	21097	19588	21097	+	DSF1	YEL070W		19588,	21097,	Deletion suppressor of mpt5 mutation
chrV	21536	23231	21536	23231	-	HXT13	YEL069C		21536,	23231,	Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose
chrV	25645	25978	25645	25978	-	YEL068C	YEL068C		25645,	25978,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	26188	26776	26188	26776	-	YEL067C	YEL067C		26188,	26776,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrV	26666	27206	26666	27206	+	HPA3	YEL066W		26666,	27206,	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated  similar to Hpa2p, acetylates histones weakly in vitro
chrV	27656	29543	27656	29543	+	SIT1	YEL065W		27656,	29543,	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates  transcription is induced during iron deprivation and diauxic shift  potentially phosphorylated by Cdc28p
chrV	29796	31239	29796	31239	-	AVT2	YEL064C		29796,	31239,	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
chrV	31693	33466	31693	33466	-	CAN1	YEL063C		31693,	33466,	Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts  mutation confers canavanine resistance
chrV	34406	36254	34406	36254	+	NPR2	YEL062W		34406,	36254,	Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation  subunit of SEA (Seh1-associated) complex  homolog of human NPRL2  target of Grr1p  required for growth on urea and proline
chrV	36534	39537	36534	39537	-	CIN8	YEL061C		36534,	39537,	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
chrV	40045	41953	40045	41953	-	PRB1	YEL060C		40045,	41953,	Vacuolar proteinase B (yscB), a serine protease of the subtilisin family  involved in protein degradation in the vacuole and required for full protein degradation during sporulation  activity inhibited by Pbi2p
chrV	42399	42624	42399	42624	-	SOM1	YEL059C-A		42399,	42624,	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space  Som1p facilitates cleavage of a subset of substrates  contains twin cysteine-x9-cysteine motifs
chrV	42651	42960	42651	42960	+	HHY1	YEL059W		42651,	42960,	Dubious open reading frame unlikely to encode a functional protein  mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking
chrV	43251	44925	43251	44925	+	PCM1	YEL058W		43251,	44925,	Essential N-acetylglucosamine-phosphate mutase  converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
chrV	45019	45721	45019	45721	-	YEL057C	YEL057C		45019,	45721,	Protein of unknown function involved in telomere maintenance  target of UME6 regulation
chrV	47167	48373	47167	48373	+	HAT2	YEL056W		47167,	48373,	Subunit of the Hat1p-Hat2p histone acetyltransferase complex  required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity  similar to human RbAp46 and 48  has a role in telomeric silencing
chrV	48470	51539	48470	51539	-	POL5	YEL055C		48470,	51539,	DNA Polymerase phi  has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication  required for the synthesis of rRNA
chrV	52720	53218	52720	53218	-	RPL12A	YEL054C		52720,	53218,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp  rpl12a rpl12b double mutant exhibits slow growth and slow translation  has similarity to E. coli L11 and rat L12 ribosomal proteins
chrV	52907	53255	52907	53255	+	YEL053W-A	YEL053W-A		52907,	53255,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YEL054C
chrV	53900	56102	53900	56102	-	MAK10	YEL053C		53900,	56102,	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus  expression is glucose-repressible
chrV	56570	58100	56570	58100	+	AFG1	YEL052W		56570,	58100,	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits  localized to matrix face of the mitochondrial inner membrane  member of the AAA family but lacks a protease domain
chrV	58377	59148	58377	59148	+	VMA8	YEL051W		58377,	59148,	Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system  plays a role in the coupling of proton transport and ATP hydrolysis
chrV	59548	59740	59548	59740	+	YEL050W-A	YEL050W-A		59548,	59740,	Dubious open reading frame unlikely to encode a functional protein  identified by fungal homology and RT-PCR
chrV	59669	60851	59669	60851	-	RML2	YEL050C		59669,	60851,	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein  fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
chrV	63727	64090	63727	64090	+	PAU2	YEL049W		63727,	64090,	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
chrV	64708	65167	64708	65167	-	TCA17	YEL048C		64708,	65167,	Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport  promotes association of TRAPPII-specific subunits with the core complex  sedlin related  human Sedlin mutations cause SEDT, a skeletal disorder
chrV	65384	66797	65384	66797	-	YEL047C	YEL047C		65384,	66797,	Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth  may interact with ribosomes, based on co-purification experiments  authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
chrV	67628	68792	67628	68792	-	GLY1	YEL046C		67628,	68792,	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine  involved in glycine biosynthesis
chrV	68839	69265	68839	69265	-	YEL045C	YEL045C		68839,	69265,	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data  deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
chrV	69756	70257	69756	70257	+	IES6	YEL044W		69756,	70257,	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions  human ortholog INO80C is a member of the human INO80 complex  implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
chrV	70477	73348	70477	73348	+	YEL043W	YEL043W		70477,	73348,	Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps  may interact with ribosomes, based on co-purification studies  contains fibronectin type III domain fold
chrV	73770	75327	73770	75327	+	GDA1	YEL042W		73770,	75327,	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
chrV	75943	77431	75943	77431	+	YEF1	YEL041W		75943,	77431,	ATP-NADH kinase  phosphorylates both NAD and NADH  homooctameric structure consisting of 60-kDa subunits  sequence similarity to Utr1p and Pos5p  overexpression complements certain pos5 phenotypes
chrV	78052	79456	78052	79456	+	UTR2	YEL040W		78052,	79456,	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall  similar to and functionally redundant with Crh1  glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
chrV	79635	79977	79635	79977	-	CYC7	YEL039C		79635,	79977,	Cytochrome c isoform 2, expressed under hypoxic conditions  electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
chrV	80461	81145	80461	81145	+	UTR4	YEL038W		80461,	81145,	Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage  found in both the cytoplasm and nucleus
chrV	81406	82603	81406	82603	-	RAD23	YEL037C		81406,	82603,	Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA  enhances protein deglycosylation activity of Png1p  also involved, with Rad4p, in ubiquitylated protein turnover
chrV	83049	84552	83049	84552	-	ANP1	YEL036C		83049,	84552,	Subunit of the alpha-1,6 mannosyltransferase complex  type II membrane protein  has a role in retention of glycosyltransferases in the Golgi  involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
chrV	85044	85545	85044	85545	-	UTR5	YEL035C		85044,	85545,	Protein of unknown function  transcription may be regulated by Gcr1p  essential for growth under standard (aerobic) conditions but not under anaerobic conditions
chrV	85612	86215	85612	86215	-	YEL034C-A	YEL034C-A		85612,	86215,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
chrV	85675	86149	85675	86149	+	HYP2	YEL034W		85675,	86149,	Translation elongation factor eIF-5A that may function in translation initiation  similar to and functionally redundant with Anb1p  structural homolog of bacterial EF-P  undergoes an essential hypusination modification
chrV	86178	86598	86178	86598	+	MTC7	YEL033W		86178,	86598,	Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites  null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
chrV	86936	89852	86936	89852	+	MCM3	YEL032W		86936,	89852,	Protein involved in DNA replication  component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
chrV	87039	87201	87039	87201	-	YEL032C-A	YEL032C-A		87039,	87201,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrV	90257	93905	90257	93905	+	SPF1	YEL031W		90257,	93905,	P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis  required for regulating Hmg2p degradation  confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
chrV	94582	94897	94582	94897	-	YEL030C-A	YEL030C-A		94582,	94897,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrV	94643	96578	94643	96578	+	ECM10	YEL030W		94643,	96578,	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner  overexpression induces extensive mitochondrial DNA aggregations
chrV	96857	97796	96857	97796	-	BUD16	YEL029C		96857,	97796,	Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6  required for genome integrity  involved in bud-site selection  similarity to yeast BUD17 and human pyridoxal kinase (PDXK)
chrV	98667	99129	98667	99129	+	YEL028W	YEL028W		98667,	99129,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrV	100768	101251	100768	101251	+	VMA3	YEL027W		100768,	101251,	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c  dicyclohexylcarbodiimide binding subunit)  required for vacuolar acidification and important for copper and iron metal ion homeostasis
chrV	101942	102323	101942	102323	+	SNU13	YEL026W		101942,	102323,	RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
chrV	102580	106147	102580	106147	-	YEL025C	YEL025C		102580,	106147,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrV	107259	107907	107259	107907	+	RIP1	YEL024W		107259,	107907,	Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex  transfers electrons from ubiquinol to cytochrome c1 during respiration
chrV	108503	110552	108503	110552	-	YEL023C	YEL023C		108503,	110552,	Putative protein of unknown function  expression is increased greatly during sporulation  YEL023C is not an essential gene
chrV	111420	115800	111420	115800	+	GEA2	YEL022W		111420,	115800,	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization  similar to but not functionally redundant with Gea1p
chrV	116166	116970	116166	116970	+	URA3	YEL021W		116166,	116970,	Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP)  converts 5-FOA into 5-fluorouracil, a toxic compound
chrV	117182	117380	117182	117380	-	YEL020C-B	YEL020C-B		117182,	117380,	Dubious open reading frame unlikely to encode a protein  partially overlaps verified gene YEL020W-A  identified by fungal homology and RT-PCR
chrV	117210	117474	117210	117474	+	TIM9	YEL020W-A		117210,	117474,	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
chrV	118616	120299	118616	120299	-	YEL020C	YEL020C		118616,	120299,	Hypothetical protein with low sequence identity to Pdc1p
chrV	120497	121301	120497	121301	-	MMS21	YEL019C		120497,	121301,	SUMO ligase involved in chromosomal organization and DNA repair  essential subunit of the Mms21-Smc5-Smc6 complex  mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
chrV	121454	121988	121454	121988	-	YEL018C-A	YEL018C-A		121454,	121988,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	121470	122310	121470	122310	+	EAF5	YEL018W		121470,	122310,	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
chrV	122797	122929	122797	122929	-	PMP2	YEL017C-A		122797,	122929,	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p)  regulates plasma membrane H(+)-ATPase activity  nearly identical to PMP1
chrV	123656	124670	123656	124670	+	GTT3	YEL017W		123656,	124670,	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data  GFP-fusion protein localizes to the nuclear periphery
chrV	124736	126218	124736	126218	-	NPP2	YEL016C		124736,	126218,	Nucleotide pyrophosphatase/phosphodiesterase family member  mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p  activity and expression enhanced during conditions of phosphate starvation
chrV	126628	128284	126628	128284	+	EDC3	YEL015W		126628,	128284,	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p  localizes to cytoplasmic mRNA processing bodies
chrV	128302	128608	128302	128608	-	YEL014C	YEL014C		128302,	128608,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	128824	130561	128824	130561	+	VAC8	YEL013W		128824,	130561,	Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway  interacts with Nvj1p to form nucleus-vacuole junctions
chrV	131771	132551	131771	132551	+	UBC8	YEL012W		131771,131899,	131776,132551,	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase)  cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
chrV	133119	135234	133119	135234	+	GLC3	YEL011W		133119,	135234,	Glycogen branching enzyme, involved in glycogen accumulation  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrV	136278	136629	136278	136629	+	YEL010W	YEL010W		136278,	136629,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	136370	136778	136370	136778	-	YEL009C-A	YEL009C-A		136370,	136778,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	138917	139763	138917	139763	-	GCN4	YEL009C		138917,	139763,	Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation  expression is tightly regulated at both the transcriptional and translational levels
chrV	140511	140892	140511	140892	+	YEL008W	YEL008W		140511,	140892,	Hypothetical protein predicted to be involved in metabolism
chrV	140725	140818	140725	140818	-	YEL008C-A	YEL008C-A		140725,	140818,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrV	141891	143892	141891	143892	+	YEL007W	YEL007W		141891,	143892,	Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
chrV	144326	145334	144326	145334	+	YEA6	YEL006W		144326,	145334,	Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6)  has putative human ortholog
chrV	145906	146755	145906	146755	-	VAB2	YEL005C		145906,	146755,	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p  likely member of BLOC complex involved in endosomal cargo sorting  Vab2p-GFP-fusion localizes to cytoplasm in punctate patter
chrV	146950	147979	146950	147979	+	YEA4	YEL004W		146950,	147979,	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis  localized to the ER
chrV	148175	148599	148175	148599	+	GIM4	YEL003W		148175,148282,	148194,148599,	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
chrV	148721	150014	148721	150014	-	WBP1	YEL002C		148721,	150014,	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex  required for N-linked glycosylation of proteins in the endoplasmic reticulum
chrV	150300	150978	150300	150978	-	IRC22	YEL001C		150300,	150978,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion localizes to the ER  YEL001C is non-essential  null mutant displays increased levels of spontaneous Rad52p foci
chrV	153519	155808	153519	155808	+	MNN1	YER001W		153519,	155808,	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
chrV	156802	157498	156802	157498	+	NOP16	YER002W		156802,	157498,	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
chrV	157735	159118	157735	159118	-	PMI40	YER003C		157735,159087,	158994,159118,	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P  required for early steps in protein mannosylation
chrV	159579	160275	159579	160275	+	FMP52	YER004W		159579,	160275,	Protein of unknown function, localized to the mitochondrial outer membrane  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrV	160549	162442	160549	162442	+	YND1	YER005W		160549,	162442,	Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases  partially redundant with Gda1p  mediates adenovirus E4orf4-induced toxicity
chrV	162722	164285	162722	164285	+	NUG1	YER006W		162722,	164285,	GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
chrV	164343	164661	164343	164661	-	YER006C-A	YER006C-A		164343,	164661,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF PAC2
chrV	164526	166083	164526	166083	+	PAC2	YER007W		164526,	166083,	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
chrV	166236	166885	166236	166885	-	TMA20	YER007C-A		166236,166874,	166771,166885,	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain  interacts with Tma22p  null mutant exhibits translation defects  has homology to human oncogene MCT-1
chrV	167807	171818	167807	171818	-	SEC3	YER008C		167807,	171818,	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis  Sec3p specifically is a spatial landmark for secretion
chrV	172114	172492	172114	172492	+	NTF2	YER009W		172114,	172492,	Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
chrV	172633	173338	172633	173338	-	YER010C	YER010C		172633,	173338,	Protein of unknown function, forms a ring-shaped homotrimer  has similarity to members of the prokaryotic rraA family  possibly involved in a phosphotransfer reaction
chrV	175247	176012	175247	176012	+	TIR1	YER011W		175247,	176012,	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins  expression is downregulated at acidic pH and induced by cold shock and anaerobiosis  abundance is increased in cells cultured without shaking
chrV	177834	178431	177834	178431	+	PRE1	YER012W		177834,	178431,	Beta 4 subunit of the 20S proteasome  localizes to the nucleus throughout the cell cycle
chrV	178840	182278	178840	182278	+	PRP22	YER013W		178840,	182278,	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing  mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
chrV	182599	184219	182599	184219	+	HEM14	YER014W		182599,	184219,	Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX  inhibited by diphenyl ether-type herbicides
chrV	183730	184700	183730	184700	-	BUD25	YER014C-A		183730,184677,	184169,184700,	Protein involved in bud-site selection  diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
chrV	184540	186775	184540	186775	+	FAA2	YER015W		184540,	186775,	Medium chain fatty acyl-CoA synthetase, activates imported fatty acids  accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0  localized to the peroxisome
chrV	188276	189311	188276	189311	+	BIM1	YER016W		188276,	189311,	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
chrV	189502	191788	189502	191788	-	AFG3	YER017C		189502,	191788,	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
chrV	191958	192624	191958	192624	-	SPC25	YER018C		191958,	192624,	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p)  involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
chrV	192796	194230	192796	194230	+	ISC1	YER019W		192796,	194230,	Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide  activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol  mediates Na+ and Li+ halotolerance
chrV	194272	194539	194272	194539	-	SBH2	YER019C-A		194272,	194539,	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum  homologous to Sbh1p
chrV	195167	196517	195167	196517	+	GPA2	YER020W		195167,	196517,	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
chrV	196947	198519	196947	198519	+	RPN3	YER021W		196947,	198519,	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome  temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
chrV	198811	200875	198811	200875	+	SRB4	YER022W		198811,	200875,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation  homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
chrV	201075	201936	201075	201936	+	PRO3	YER023W		201075,	201936,	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
chrV	201521	201734	201521	201734	-	YER023C-A	YER023C-A		201521,	201734,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps verified gene PRO3  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrV	202191	204963	202191	204963	+	YAT2	YER024W		202191,	204963,	Carnitine acetyltransferase  has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
chrV	205250	206834	205250	206834	+	GCD11	YER025W		205250,	206834,	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon  binds GTP when forming the ternary complex with GTP and tRNAi-Met
chrV	207643	208474	207643	208474	-	CHO1	YER026C		207643,	208474,	Phosphatidylserine synthase, functions in phospholipid biosynthesis  catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
chrV	208978	210232	208978	210232	-	GAL83	YER027C		208978,	210232,	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source  contains glycogen-binding domain
chrV	210691	211876	210691	211876	-	MIG3	YER028C		210691,	211876,	Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase  phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
chrV	212586	213177	212586	213177	-	SMB1	YER029C		212586,	213177,	Core Sm protein Sm B  part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs  homolog of human Sm B and Sm B'
chrV	213436	213898	213436	213898	+	CHZ1	YER030W		213436,	213898,	Histone chaperone for Htz1p/H2A-H2B dimer  required for the stabilization of the Chz1p-Htz1-H2B complex  has overlapping function with Nap1p  null mutant displays weak sensitivity to MMS and benomyl  contains a highly conserved CHZ motif
chrV	214075	214747	214075	214747	-	YPT31	YER031C		214075,	214747,	Rab family GTPase, very similar to Ypt32p  involved in the exocytic pathway  mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
chrV	215062	217693	215062	217693	+	FIR1	YER032W		215062,	217693,	Protein involved in 3' mRNA processing, interacts with Ref2p  potential Cdc28p substrate
chrV	218056	221287	218056	221287	-	ZRG8	YER033C		218056,	221287,	Protein of unknown function  authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  GFP-fusion protein is localized to the cytoplasm  transcription induced under conditions of zinc deficiency
chrV	221845	222403	221845	222403	+	YER034W	YER034W		221845,	222403,	Putative protein of unknown function  non-essential gene  expression induced upon calcium shortage
chrV	222638	223076	222638	223076	+	EDC2	YER035W		222638,	223076,	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p  has a role in translation during heat stress
chrV	223366	225199	223366	225199	-	ARB1	YER036C		223366,	225199,	ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p  shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
chrV	225888	226854	225888	226854	+	PHM8	YER037W		225888,	226854,	Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation  phosphatase activity is soluble and Mg2+ dependent  expression is induced by low phosphate levels and by inactivation of Pho85p
chrV	226857	228252	226857	228252	-	KRE29	YER038C		226857,	228252,	Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair  heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
chrV	228450	228831	228450	228831	+	YER038W-A	YER038W-A		228450,	228831,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  99% of ORF overlaps the verified gene HVG1  protein product detected in mitochondria
chrV	228455	229205	228455	229205	-	HVG1	YER039C		228455,	229205,	Protein of unknown function, has homology to Vrg4p
chrV	229262	229481	229262	229481	-	YER039C-A	YER039C-A		229262,	229481,	Putative protein of unknown function  YER039C-A is not an essential gene
chrV	229794	231987	229794	231987	+	GLN3	YER040W		229794,	231987,	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
chrV	232460	234740	232460	234740	+	YEN1	YER041W		232460,	234740,	Holliday junction resolvase  localization is cell-cycle dependent and regulated by Cdc28p phosphorylation  homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
chrV	234936	235491	234936	235491	+	MXR1	YER042W		234936,	235491,	Methionine-S-sulfoxide reductase, involved in the response to oxidative stress  protects iron-sulfur clusters from oxidative inactivation along with MXR2  involved in the regulation of lifespan
chrV	235769	237119	235769	237119	-	SAH1	YER043C		235769,	237119,	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
chrV	237569	238016	237569	238016	-	ERG28	YER044C		237569,	238016,	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
chrV	238459	239774	238459	239774	-	MEI4	YER044C-A		238459,239711,	239623,239774,	Meiosis-specific protein involved in double-strand break formation during meiotic recombination  required for chromosome synapsis and production of viable spores
chrV	240031	241501	240031	241501	-	ACA1	YER045C		240031,	241501,	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
chrV	243179	243611	243179	243611	+	SPO73	YER046W		243179,	243611,	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation  dispensible for both nuclear divisions during meiosis
chrV	243699	244029	243699	244029	+	YER046W-A	YER046W-A		243699,	244029,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	243809	246503	243809	246503	-	SAP1	YER047C		243809,	246503,	Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
chrV	246981	248157	246981	248157	-	CAJ1	YER048C		246981,	248157,	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
chrV	250717	251002	250717	251002	+	ISD11	YER048W-A		250717,	251002,	Protein required for mitochondrial iron-sulfur cluster biosynthesis
chrV	251727	253662	251727	253662	+	TPA1	YER049W		251727,	253662,	Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability  interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p  similar to prolyl 4-hydroxylases  binds Fe(III) and 2-oxoglutarate
chrV	253970	254387	253970	254387	-	RSM18	YER050C		253970,	254387,	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
chrV	254655	256134	254655	256134	+	JHD1	YER051W		254655,	256134,	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
chrV	256374	257958	256374	257958	-	HOM3	YER052C		256374,	257958,	Aspartate kinase (L-aspartate 4-P-transferase)  cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis  expression regulated by Gcn4p and the general control of amino acid synthesis
chrV	258736	259639	258736	259639	-	PIC2	YER053C		258736,	259639,	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria  functionally redundant with Mir1p but less abundant than Mir1p under normal conditions  expression is induced at high temperature
chrV	260932	261046	260932	261046	-	YER053C-A	YER053C-A		260932,	261046,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
chrV	262051	263698	262051	263698	-	GIP2	YER054C		262051,	263698,	Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism  contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
chrV	264891	265785	264891	265785	-	HIS1	YER055C		264891,	265785,	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis  mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts  transcription is regulated by general amino acid control
chrV	266511	268113	266511	268113	-	FCY2	YER056C		266511,	268113,	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
chrV	269422	270185	269422	270185	-	RPL34A	YER056C-A		269422,270148,	269751,270185,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
chrV	270736	271126	270736	271126	-	HMF1	YER057C		270736,	271126,	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria  heat shock inducible  high-dosage growth inhibitor  forms a homotrimer in vitro
chrV	271767	272091	271767	272091	+	PET117	YER058W		271767,	272091,	Protein required for assembly of cytochrome c oxidase
chrV	272623	273886	272623	273886	+	PCL6	YER059W		272623,	273886,	Pho85p cyclin of the Pho80p subfamily  forms the major Glc8p kinase together with Pcl7p and Pho85p  involved in the control of glycogen storage by Pho85p  stabilized by Elongin C binding
chrV	274566	276153	274566	276153	+	FCY21	YER060W		274566,	276153,	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
chrV	276571	278164	276571	278164	+	FCY22	YER060W-A		276571,	278164,	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
chrV	278297	279626	278297	279626	-	CEM1	YER061C		278297,	279626,	Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis  required for mitochondrial respiration
chrV	279929	280682	279929	280682	-	HOR2	YER062C		279929,	280682,	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis  induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
chrV	281709	282366	281709	282366	+	THO1	YER063W		281709,	282366,	Conserved nuclear RNA-binding protein  specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2  overproduction suppresses transcriptional defect caused by hpr1 mutation
chrV	282704	284222	282704	284222	-	YER064C	YER064C		282704,	284222,	Non-essential nuclear protein  null mutation has global effects on transcription
chrV	285240	286914	285240	286914	-	ICL1	YER065C		285240,	286914,	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle  expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
chrV	290241	290799	290241	290799	+	RRT13	YER066W		290241,	290799,	Putative protein of unknown function  non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
chrV	291702	292203	291702	292203	-	YER066C-A	YER066C-A		291702,	292203,	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
chrV	292065	292551	292065	292551	+	RGI1	YER067W		292065,	292551,	Protein of unknown function involved in energy metabolism under respiratory conditions  protein abundance is increased upon intracellular iron depletion
chrV	292239	292563	292239	292563	-	YER067C-A	YER067C-A		292239,	292563,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YER067W
chrV	293049	294813	293049	294813	+	MOT2	YER068W		293049,	294813,	Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications  with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p
chrV	295300	295732	295300	295732	-	YER068C-A	YER068C-A		295300,	295732,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	295409	298001	295409	298001	+	ARG5,6	YER069W		295409,	298001,	Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis  enzymes form a complex with Arg2p
chrV	298949	301616	298949	301616	+	RNR1	YER070W		298949,	301616,	Major isoform of the large subunit of ribonucleotide-diphosphate reductase  the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
chrV	301946	302327	301946	302327	-	YER071C	YER071C		301946,	302327,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern  null mutant is sensitive to expression of the top1-T722A allele
chrV	302805	303195	302805	303195	+	VTC1	YER072W		302805,	303195,	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion  also has mRNA binding activity
chrV	304029	305592	304029	305592	+	ALD5	YER073W		304029,	305592,	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation  activated by K+  utilizes NADP+ as the preferred coenzyme  constitutively expressed
chrV	306322	307196	306322	307196	+	RPS24A	YER074W		306322,306791,	306325,307196,	Protein component of the small (40S) ribosomal subunit  identical to Rps24Bp and has similarity to rat S24 ribosomal protein
chrV	307652	308123	307652	308123	+	YOS1	YER074W-A		307652,307848,308067,	307746,307956,308123,	Integral membrane protein required for ER to Golgi transport  localized to the Golgi, the ER, and COPII vesicles  interacts with Yip1p and Yif1p
chrV	308412	311199	308412	311199	-	PTP3	YER075C		308412,	311199,	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing  dephosporylates Hog1p MAPK and regulates its localization  localized to the cytoplasm
chrV	312589	313498	312589	313498	-	YER076C	YER076C		312589,	313498,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  analysis of HA-tagged protein suggests a membrane localization
chrV	313389	313737	313389	313737	+	YER076W-A	YER076W-A		313389,	313737,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YER076C
chrV	314533	316600	314533	316600	-	YER077C	YER077C		314533,	316600,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion  null mutation results in a decrease in plasma membrane electron transport
chrV	316806	318342	316806	318342	-	ICP55	YER078C		316806,	318342,	Mitochondrial aminopeptidase  cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability  member of the aminopeptidase P family
chrV	318645	318810	318645	318810	+	YER078W-A	YER078W-A		318645,	318810,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrV	318919	319552	318919	319552	+	YER079W	YER079W		318919,	319552,	Putative protein of unknown function
chrV	319901	320240	319901	320240	-	YER079C-A	YER079C-A		319901,	320240,	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER080W
chrV	319962	321846	319962	321846	+	AIM9	YER080W		319962,	321846,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  null mutant displays elevated frequency of mitochondrial genome loss
chrV	322685	324095	322685	324095	+	SER3	YER081W		322685,	324095,	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis  isozyme of Ser33p
chrV	324271	325936	324271	325936	-	UTP7	YER082C		324271,	325936,	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
chrV	326173	327031	326173	327031	-	GET2	YER083C		326173,	327031,	Subunit of the GET complex  involved in insertion of proteins into the ER membrane  required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
chrV	327064	327451	327064	327451	+	YER084W	YER084W		327064,	327451,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrV	327597	328110	327597	328110	+	YER084W-A	YER084W-A		327597,	328110,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	327618	328140	327618	328140	-	YER085C	YER085C		327618,	328140,	Putative protein of unknown function
chrV	328476	330207	328476	330207	+	ILV1	YER086W		328476,	330207,	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis  expression is under general amino acid control  ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
chrV	330575	332306	330575	332306	+	AIM10	YER087W		330575,	332306,	Protein with similarity to tRNA synthetases  non-tagged protein is detected in purified mitochondria  null mutant is viable and displays elevated frequency of mitochondrial genome loss
chrV	331816	332368	331816	332368	-	YER087C-A	YER087C-A		331816,	332368,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
chrV	332581	332830	332581	332830	-	SBH1	YER087C-B		332581,	332830,	Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p)  involved in protein translocation into the endoplasmic reticulum  interacts with the exocyst complex and also with Rtn1p  homologous to Sbh2p
chrV	333175	335188	333175	335188	-	DOT6	YER088C		333175,	335188,	Protein involved in rRNA and ribosome biogenesis  binds polymerase A and C motif  subunit of the RPD3L histone deacetylase complex  similar to Tod6p  has chromatin specific SANT domain  involved in telomeric gene silencing and filamentation
chrV	335695	336019	335695	336019	-	YER088C-A	YER088C-A		335695,	336019,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	335926	336073	335926	336073	+	YER088W-B	YER088W-B		335926,	336073,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the ORF PTC2/YER089C  identified by gene-trapping, expression analysis, and homology searching
chrV	335945	337340	335945	337340	-	PTC2	YER089C		335945,	337340,	Type 2C protein phosphatase (PP2C)  dephosphorylates Hog1p to limit maximal osmostress induced kinase activity  dephosphorylates Ire1p to downregulate the unfolded protein response  dephosphorylates Cdc28p  inactivates the DNA damage checkpoint
chrV	337948	339472	337948	339472	+	TRP2	YER090W		337948,	339472,	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
chrV	338321	338411	338321	338411	-	YER090C-A	YER090C-A		338321,	338411,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	339863	342167	339863	342167	-	MET6	YER091C		339863,	342167,	Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration  requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
chrV	342389	342611	342389	342611	-	YER091C-A	YER091C-A		342389,	342611,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrV	342854	343232	342854	343232	+	IES5	YER092W		342854,	343232,	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
chrV	343319	347612	343319	347612	-	TSC11	YER093C		343319,	347612,	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity  involved in sphingolipid metabolism  contains a RasGEFN domain
chrV	347911	348400	347911	348400	-	AIM11	YER093C-A		347911,348276,	348201,348400,	Protein of unknown function  null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1)  contains an intron
chrV	348728	349346	348728	349346	-	PUP3	YER094C		348728,	349346,	Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism  human homolog is subunit C10
chrV	349979	351182	349979	351182	+	RAD51	YER095W		349979,	351182,	Strand exchange protein, forms a helical filament with DNA that searches for homology  involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis  homolog of Dmc1p and bacterial RecA protein
chrV	351697	353236	351697	353236	+	SHC1	YER096W		351697,	353236,	Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores  has similarity to Skt5p, which activates Chs3p during vegetative growth  transcriptionally induced at alkaline pH
chrV	355139	355469	355139	355469	+	YER097W	YER097W		355139,	355469,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	355465	357730	355465	357730	+	UBP9	YER098W		355465,	357730,	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
chrV	358104	359061	358104	359061	-	PRS2	YER099C		358104,	359061,	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis  one of five related enzymes, which are active as heteromultimeric complexes
chrV	359561	360314	359561	360314	+	UBC6	YER100W		359561,	360314,	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation  located at the cytosolic side of the ER membrane  tail region contains a transmembrane segment at the C-terminus  substrate of the ubiquitin-proteasome pathway
chrV	360501	361794	360501	361794	-	AST2	YER101C		360501,	361794,	Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
chrV	363099	363702	363099	363702	+	RPS8B	YER102W		363099,	363702,	Protein component of the small (40S) ribosomal subunit  identical to Rps8Ap and has similarity to rat S8 ribosomal protein
chrV	364588	366517	364588	366517	+	SSA4	YER103W		364588,	366517,	Heat shock protein that is highly induced upon stress  plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation  member of the HSP70 family  cytoplasmic protein that concentrates in nuclei upon starvation
chrV	366801	367428	366801	367428	+	RTT105	YER104W		366801,	367428,	Protein with a role in regulation of Ty1 transposition
chrV	367837	372013	367837	372013	-	NUP157	YER105C		367837,	372013,	Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC  has similarity to Nup170p  essential role, with Nup170p, in NPC assembly
chrV	372325	373234	372325	373234	+	MAM1	YER106W		372325,	373234,	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
chrV	373447	374545	373447	374545	-	GLE2	YER107C		373447,	374545,	Component of the Nup82 subcomplex of the nuclear pore complex  required for polyadenylated RNA export but not for protein import  homologous to S. pombe Rae1p
chrV	374393	374714	374393	374714	+	YER107W-A	YER107W-A		374393,	374714,	Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
chrV	375214	377614	375214	377614	-	FLO8	YER109C		375214,	377614,	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth  genome reference strain S288C and most laboratory strains have a mutation in this gene
chrV	378761	382103	378761	382103	-	KAP123	YER110C		378761,	382103,	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4  localizes to the nuclear pore, nucleus, and cytoplasm  exhibits genetic interactions with RAI1
chrV	382594	385876	382594	385876	-	SWI4	YER111C		382594,	385876,	DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
chrV	387231	387795	387231	387795	+	LSM4	YER112W		387231,	387795,	Lsm (Like Sm) protein  part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay  nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
chrV	387931	390052	387931	390052	-	TMN3	YER113C		387931,	390052,	Protein with a role in cellular adhesion and filamentous growth  similar to Emp70p and Tmn2p  member of Transmembrane Nine family with 9 transmembrane segments  localizes to Golgi  induced by 8-methoxypsoralen plus UVA irradiation
chrV	390589	393712	390589	393712	-	BOI2	YER114C		390589,	393712,	Protein implicated in polar growth, functionally redundant with Boi1p  interacts with bud-emergence protein Bem1p  contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
chrV	394291	394867	394291	394867	-	SPR6	YER115C		394291,	394867,	Protein of unknown function, expressed during sporulation  not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
chrV	395347	396172	395347	396172	-	SLX8	YER116C		395347,	396172,	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex  stimulated by prior attachment of SUMO to the substrate  contains a C-terminal RING domain
chrV	396768	397653	396768	397653	+	RPL23B	YER117W		396768,397281,	396810,397653,	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
chrV	397951	399055	397951	399055	-	SHO1	YER118C		397951,	399055,	Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway  phosphorylated by Hog1p  interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
chrV	399495	400842	399495	400842	-	AVT6	YER119C		399495,	400842,	Vacuolar aspartate and glutamate exporter  member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters  involved in compartmentalizing acidic amino acids in response to nitrogen starvation
chrV	400866	401238	400866	401238	-	YER119C-A	YER119C-A		400866,	401238,	Dubious open reading frame, not conserved in closely related Saccharomyces species  deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
chrV	401134	401869	401134	401869	+	SCS2	YER120W		401134,	401869,	Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
chrV	402374	402719	402374	402719	+	YER121W	YER121W		402374,	402719,	Putative protein of unknown function  may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
chrV	402870	404352	402870	404352	-	GLO3	YER122C		402870,	404352,	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport  shares functional similarity with Gcs1p
chrV	404812	406387	404812	406387	+	YCK3	YER123W		404812,	406387,	Palmitoylated, vacuolar membrane-localized casein kinase I isoform  negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p  shares essential functions with Hrr25p  regulates vesicle fusion in AP-3 pathway
chrV	407341	409063	407341	409063	-	DSE1	YER124C		407341,	409063,	Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways  deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall
chrV	410188	412618	410188	412618	+	RSP5	YER125W		410188,	412618,	E3 ubiquitin ligase of the NEDD4 family  involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability  human homolog is involved in Liddle syndrome  mutant tolerates aneuploidy
chrV	413393	414179	413393	414179	-	NSA2	YER126C		413393,	414179,	Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
chrV	414480	415554	414480	415554	+	LCP5	YER127W		414480,	415554,	Essential protein involved in maturation of 18S rRNA  depletion leads to inhibited pre-rRNA processing and reduced polysome levels  localizes primarily to the nucleolus
chrV	415858	416470	415858	416470	+	YER128W	YER128W		415858,	416470,	Protein that interacts with Vps4p and has a role in vacuolar sorting  localizes to endosomes in a Vps4-dependent manner  overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
chrV	417280	420709	417280	420709	+	SAK1	YER129W		417280,	420709,	Upstream serine/threonine kinase for the SNF1 complex  partially redundant with Elm1p and Tos3p  members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
chrV	421114	422446	421114	422446	-	YER130C	YER130C		421114,	422446,	Protein of unknown function  transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators  the C. Albicans homolog (MNL1) plays a role in adaptation to stress
chrV	423951	424311	423951	424311	+	RPS26B	YER131W		423951,	424311,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
chrV	425187	430449	425187	430449	-	PMD1	YER132C		425187,	430449,	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression  required, with Mds3p, for growth under alkaline conditions
chrV	432494	433958	432494	433958	+	GLC7	YER133W		432494,433196,	432671,433958,	Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis)  accumulates at mating projections by interaction with Afr1p  interacts with many regulatory subunits
chrV	437190	437532	437190	437532	+	YER133W-A	YER133W-A		437190,	437532,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps uncharacterized gene YER134C.
chrV	437266	437803	437266	437803	-	YER134C	YER134C		437266,	437803,	Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily  non-essential gene
chrV	437951	438344	437951	438344	-	YER135C	YER135C		437951,	438344,	Dubious open reading frame unlikely to encode a protein  YER135C is not an essential gene
chrV	439615	440971	439615	440971	+	GDI1	YER136W		439615,	440971,	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
chrV	441372	441819	441372	441819	-	YER137C	YER137C		441372,	441819,	Putative protein of unknown function
chrV	441574	441880	441574	441880	+	YER137W-A	YER137W-A		441574,	441880,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	443755	449024	443755	449024	-	YER138C	YER138C		443755,447722,	447721,449024,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrV	447701	449024	447701	449024	-	YER137C-A	YER137C-A		447701,	449024,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrV	449473	449578	449473	449578	+	YER138W-A	YER138W-A		449473,	449578,	Putative protein of unknown function
chrV	450562	451243	450562	451243	-	RTR1	YER139C		450562,	451243,	CTD phosphatase  dephosphorylates S5-P in the C-terminal domain of Rpo21p  has a cysteine-rich motif required for function and conserved in eukaryotes  shuttles between the nucleus and cytoplasm
chrV	451564	453235	451564	453235	+	YER140W	YER140W		451564,	453235,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  genetic interactions suggest a role in folding of ER membrane proteins
chrV	453458	454919	453458	454919	+	COX15	YER141W		453458,	454919,	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
chrV	455145	456036	455145	456036	-	MAG1	YER142C		455145,	456036,	3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents  initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
chrV	456318	457605	456318	457605	+	DDI1	YER143W		456318,	457605,	DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion  may play a role in S-phase checkpoint control  has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains
chrV	457805	460223	457805	460223	-	UBP5	YER144C		457805,	460223,	Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap  concentrates at the bud neck
chrV	460525	461740	460525	461740	-	FTR1	YER145C		460525,	461740,	High affinity iron permease involved in the transport of iron across the plasma membrane  forms complex with Fet3p  expression is regulated by iron
chrV	462385	462823	462385	462823	-	YER145C-A	YER145C-A		462385,	462823,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified ORF LSM5/YER146W
chrV	462584	462866	462584	462866	+	LSM5	YER146W		462584,	462866,	Lsm (Like Sm) protein  part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay  nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
chrV	462967	464842	462967	464842	-	SCC4	YER147C		462967,	464842,	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes  involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
chrV	465202	465613	465202	465613	-	YER147C-A	YER147C-A		465202,	465613,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	465302	466025	465302	466025	+	SPT15	YER148W		465302,	466025,	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
chrV	466184	466763	466184	466763	+	YER148W-A	YER148W-A		466184,	466763,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	466207	467470	466207	467470	-	PEA2	YER149C		466207,	467470,	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx  forms polarisome complex with Bni1p, Bud6p, and Spa2p  localizes to sites of polarized growth
chrV	468369	468816	468369	468816	+	SPI1	YER150W		468369,	468816,	GPI-anchored cell wall protein involved in weak acid resistance  basal expression requires Msn2p/Msn4p  expression is induced under conditions of stress and during the diauxic shift  similar to Sed1p
chrV	469685	472424	469685	472424	-	UBP3	YER151C		469685,	472424,	Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi  inhibitor of gene silencing  cleaves ubiquitin fusions but not polyubiquitin  also has mRNA binding activity
chrV	472656	473988	472656	473988	-	YER152C	YER152C		472656,	473988,	Protein with 2-aminoadipate transaminase activity  shares amino acid similarity with the aminotransferases Aro8p and Aro9p  YER152C is not an essential gene
chrV	473484	474051	473484	474051	+	YER152W-A	YER152W-A		473484,	474051,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	474040	474805	474040	474805	-	PET122	YER153C		474040,	474805,	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p  located in the mitochondrial inner membrane
chrV	475019	476228	475019	476228	+	OXA1	YER154W		475019,	476228,	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes  conserved from bacteria to animals
chrV	476344	482848	476344	482848	-	BEM2	YER155C		476344,	482848,	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis  required for bud emergence
chrV	483324	484341	483324	484341	-	YER156C	YER156C		483324,	484341,	Putative protein of unknown function  interacts with Hsp82p and copurifies with Ipl1p  expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor  similarity to mammalian MYG1
chrV	484787	487193	484787	487193	+	COG3	YER157W		484787,	487193,	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrV	488856	490578	488856	490578	-	YER158C	YER158C		488856,	490578,	Protein of unknown function, has similarity to Afr1p  potentially phosphorylated by Cdc28p
chrV	491486	491702	491486	491702	+	YER158W-A	YER158W-A		491486,	491702,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrV	491529	491958	491529	491958	-	BUR6	YER159C		491529,	491958,	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p  complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription  homologous to human NC2alpha
chrV	492855	498124	492855	498124	-	YER160C	YER160C		492855,496822,	496821,498124,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrV	496801	498124	496801	498124	-	YER159C-A	YER159C-A		496801,	498124,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrV	499346	500348	499346	500348	-	SPT2	YER161C		499346,	500348,	Protein involved in negative regulation of transcription  required for RNA polyadenylation  exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
chrV	500629	502894	500629	502894	-	RAD4	YER162C		500629,	502894,	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair  subunit of Nuclear Excision Repair Factor 2 (NEF2)  also involved, with Rad23p, in turnover of ubiquitylated proteins
chrV	503083	503782	503083	503782	-	YER163C	YER163C		503083,	503782,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  periodically expressed during the metabolic cycle  weak similarity to bacterial cation transport protein
chrV	505391	509798	505391	509798	+	CHD1	YER164W		505391,	509798,	Nucleosome remodeling factor that functions in regulation of transcription elongation  contains a chromo domain, a helicase domain and a DNA-binding domain  component of both the SAGA and SLIK complexes
chrV	510372	512106	510372	512106	+	PAB1	YER165W		510372,	512106,	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
chrV	512626	512983	512626	512983	-	YER165C-A	YER165C-A		512626,	512983,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene DNF1/YER166W
chrV	512743	517459	512743	517459	+	DNF1	YER166W		512743,	517459,	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane  contributes to endocytosis, protein transport and cell polarity  type 4 P-type ATPase
chrV	518215	520771	518215	520771	+	BCK2	YER167W		518215,	520771,	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity  overproduction suppresses pkc1 mutations
chrV	521028	522669	521028	522669	-	CCA1	YER168C		521028,	522669,	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase  different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
chrV	523368	525759	523368	525759	+	RPH1	YER169W		523368,	525759,	JmjC domain-containing histone demethylase  specifically demethylates H3K36 tri- and dimethyl modification states  associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate  transcriptional repressor of PHR1  Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
chrV	525973	526651	525973	526651	+	ADK2	YER170W		525973,	526651,	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP  may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions  3' sequence of ADK2 varies with strain background
chrV	527081	529418	527081	529418	+	RAD3	YER171W		527081,	529418,	5' to 3' DNA helicase, involved in nucleotide excision repair and transcription  subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3)  homolog of human XPD protein  mutant has aneuploidy tolerance
chrV	529529	536021	529529	536021	-	BRR2	YER172C		529529,	536021,	RNA-dependent ATPase RNA helicase (DEIH box)  required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis  homologous to human U5-200kD
chrV	536274	536655	536274	536655	-	YER172C-A	YER172C-A		536274,	536655,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrV	536299	538279	536299	538279	+	RAD24	YER173W		536299,	538279,	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints  subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA  homolog of human and S. pombe Rad17 protein
chrV	538433	539168	538433	539168	-	GRX4	YER174C		538433,	539168,	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase  monothiol glutaredoxin subfamily member along with Grx3p and Grx5p  protects cells from oxidative damage  mutant has increased aneuploidy tolerance
chrV	539463	540363	539463	540363	-	TMT1	YER175C		539463,	540363,	Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
chrV	540649	540814	540649	540814	+	YER175W-A	YER175W-A		540649,	540814,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrV	541689	545055	541689	545055	+	ECM32	YER176W		541689,	545055,	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination  interacts with the translation termination factors, localized to polysomes
chrV	545610	546414	545610	546414	+	BMH1	YER177W		545610,	546414,	14-3-3 protein, major isoform  controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
chrV	546816	548079	546816	548079	+	PDA1	YER178W		546816,	548079,	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA  phosphorylated  regulated by glucose
chrV	548420	549517	548420	549517	+	DMC1	YER179W		548420,548644,	548552,549517,	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes  homolog of Rad51p and the bacterial RecA protein
chrV	549723	550527	549723	550527	-	ISC10	YER180C		549723,	550527,	Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells
chrV	550864	551122	550864	551122	-	SLO1	YER180C-A		550864,	551122,	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi  putative ortholog of human SCOCO
chrV	551472	551796	551472	551796	-	YER181C	YER181C		551472,	551796,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data  extensively overlaps a Ty1 LTR  protein product is detected in highly purified mitochondria in high-throughput studies
chrV	552524	553259	552524	553259	+	FMP10	YER182W		552524,	553259,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrV	553333	553969	553333	553969	-	FAU1	YER183C		553333,	553969,	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
chrV	556295	558680	556295	558680	-	YER184C	YER184C		556295,	558680,	Putative zinc cluster protein  deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
chrV	559453	560365	559453	560365	+	PUG1	YER185W		559453,	560365,	Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme  expression is induced under both low-heme and low-oxygen conditions  member of the fungal lipid-translocating exporter (LTE) family of proteins
chrV	561704	562625	561704	562625	-	YER186C	YER186C		561704,	562625,	Putative protein of unknown function
chrV	566229	566655	566229	566655	+	YER187W	YER187W		566229,	566655,	Putative protein of unknown function  induced in respiratory-deficient cells
chrV	568039	568759	568039	568759	+	YER188W	YER188W		568039,	568759,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p
chrV	569607	569907	569607	569907	-	YER188C-A	YER188C-A		569607,	569907,	Putative protein of unknown function
chrV	571154	571523	571154	571523	+	YER189W	YER189W		571154,	571523,	Putative protein of unknown function
chrV	571479	576525	571479	576525	+	YRF1-2	YER190W		571479,	576525,	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1  potentially phosphorylated by Cdc28p  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrV	574803	575379	574803	575379	-	YER190C-A	YER190C-A		574803,	575379,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF YRF1-2/YER190W  identified by gene-trapping, expression analysis, and homology
chrV	575679	576162	575679	576162	-	YER190C-B	YER190C-B		575679,	576162,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVI	52	535	52	535	+	YFL068W	YFL068W		52,	535,	Putative protein of unknown function
chrVI	835	1363	835	1363	+	YFL067W	YFL067W		835,	1363,	Protein of unknown function, down-regulated at low calcium levels
chrVI	1436	2615	1436	2615	-	YFL066C	YFL066C		1436,	2615,	Helicase-like protein encoded within the telomeric Y' element  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrVI	3029	3338	3029	3338	-	YFL065C	YFL065C		3029,	3338,	Putative protein of unknown function  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrVI	3321	3846	3321	3846	-	YFL064C	YFL064C		3321,	3846,	Putative protein of unknown function
chrVI	5065	5521	5065	5521	+	YFL063W	YFL063W		5065,	5521,	Dubious open reading frame, based on available experimental and comparative sequence data
chrVI	6425	7565	6425	7565	+	COS4	YFL062W		6425,	7565,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrVI	9544	10222	9544	10222	+	DDI2	YFL061W		9544,	10222,	Protein of unknown function  expression is induced over 100-fold by DNA damage  induction decreased in rad6 and rad18 mutants
chrVI	10300	10969	10300	10969	-	SNO3	YFL060C		10300,	10969,	Protein of unknown function, nearly identical to Sno2p  expression is induced before the diauxic shift and also in the absence of thiamin
chrVI	11362	12259	11362	12259	+	SNZ3	YFL059W		11362,	12259,	Member of a stationary phase-induced gene family  transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner  forms a coregulated gene pair with SNO3
chrVI	12928	13951	12928	13951	+	THI5	YFL058W		12928,	13951,	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP)  member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
chrVI	14304	14763	14304	14763	-	AAD16	YFL057C		14304,	14763,	Putative aryl-alcohol dehydrogenase  similar to P. chrysosporium aryl-alcohol dehydrogenase  mutational analysis has not yet revealed a physiological role
chrVI	14792	15431	14792	15431	-	AAD6	YFL056C		14792,	15431,	Putative aryl-alcohol dehydrogenase  involved in oxidative stress response  similar to P. chrysosporium aryl-alcohol dehydrogenase  expression induced in cells treated with the mycotoxin patulin
chrVI	17003	18680	17003	18680	+	AGP3	YFL055W		17003,	18680,	Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions  transcription is induced under conditions of sulfur limitation  plays a role in regulating Ty1 transposition
chrVI	20846	22787	20846	22787	-	YFL054C	YFL054C		20846,	22787,	Putative channel-like protein  similar to Fps1p  mediates passive diffusion of glycerol in the presence of ethanol
chrVI	23422	25198	23422	25198	+	DAK2	YFL053W		23422,	25198,	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA)  involved in stress adaptation
chrVI	28231	29629	28231	29629	+	YFL052W	YFL052W		28231,	29629,	Putative zinc cluster protein that contains a DNA binding domain  null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
chrVI	30057	30540	30057	30540	-	YFL051C	YFL051C		30057,	30540,	Putative protein of unknown function  YFL051C is not an essential gene
chrVI	33271	35848	33271	35848	-	ALR2	YFL050C		33271,	35848,	Probable Mg(2+) transporter  overexpression confers increased tolerance to Al(3+) and Ga(3+) ions  plays a role in regulating Ty1 transposition
chrVI	36802	38674	36802	38674	+	SWP82	YFL049W		36802,	38674,	Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role  has identifiable counterparts in closely related yeast species  abundantly expressed in many growth conditions  paralog of Npl6p
chrVI	38842	40180	38842	40180	-	EMP47	YFL048C		38842,	40180,	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
chrVI	40420	42565	40420	42565	+	RGD2	YFL047W		40420,	42565,	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p
chrVI	42814	43438	42814	43438	+	FMP32	YFL046W		42814,	43438,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVI	43627	44392	43627	44392	-	SEC53	YFL045C		43627,	44392,	Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose  required for folding and glycosylation of secretory proteins in the ER lumen
chrVI	44654	45560	44654	45560	-	OTU1	YFL044C		44654,	45560,	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p  may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p  member of the Ovarian Tumor (OTU) family
chrVI	45719	47744	45719	47744	-	YFL042C	YFL042C		45719,	47744,	Putative protein of unknown function  YFL042C is not an essential gene
chrVI	48733	48925	48733	48925	+	YFL041W-A	YFL041W-A		48733,	48925,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrVI	49138	51007	49138	51007	+	FET5	YFL041W		49138,	51007,	Multicopper oxidase, integral membrane protein with similarity to Fet3p  may have a role in iron transport
chrVI	51349	52972	51349	52972	+	YFL040W	YFL040W		51349,	52972,	Putative transporter, member of the sugar porter family  YFL040W is not an essential gene
chrVI	53259	54696	53259	54696	-	ACT1	YFL039C		53259,54686,	54377,54696,	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
chrVI	55365	55986	55365	55986	-	YPT1	YFL038C		55365,	55986,	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway  complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
chrVI	56335	57709	56335	57709	+	TUB2	YFL037W		56335,	57709,	Beta-tubulin  associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
chrVI	58781	62837	58781	62837	+	RPO41	YFL036W		58781,	62837,	Mitochondrial RNA polymerase  single subunit enzyme similar to those of T3 and T7 bacteriophages  requires a specificity subunit encoded by MTF1 for promoter recognition
chrVI	63015	63993	63015	63993	-	MOB2	YFL034C-B		63015,63973,	63859,63993,	Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation  similar to Mob1p
chrVI	64242	64932	64242	64932	-	RPL22B	YFL034C-A		64242,64920,	64599,64932,	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein
chrVI	65476	68698	65476	68698	+	YFL034W	YFL034W		65476,	68698,	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
chrVI	69114	74427	69114	74427	-	RIM15	YFL033C		69114,	74427,	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase  identified as a regulator of IME2  substrate of Pho80p-Pho85p kinase
chrVI	74871	75192	74871	75192	+	YFL032W	YFL032W		74871,	75192,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene HAC1/YFL031W  YFL032W is not an essential gene
chrVI	75178	76147	75178	76147	+	HAC1	YFL031W		75178,76091,	75839,76147,	Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis  ER stress-induced splicing pathway facilitates efficient Hac1p synthesis
chrVI	76013	76115	76013	76115	-	YFL031C-A	YFL031C-A		76013,	76115,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps HAC1/YFL031W  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVI	76830	77988	76830	77988	+	AGX1	YFL030W		76830,	77988,	Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast  has similarity to mammalian and plant alanine:glyoxylate aminotransferases
chrVI	78054	79161	78054	79161	-	CAK1	YFL029C		78054,	79161,	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p  nucleotide-binding pocket differs significantly from those of most other protein kinases
chrVI	79343	80213	79343	80213	-	CAF16	YFL028C		79343,	80213,	Part of evolutionarily-conserved CCR4-NOT regulatory complex  contains single ABC-type ATPase domain but no transmembrane domain  interacts with several subunits of Mediator
chrVI	80418	81912	80418	81912	-	GYP8	YFL027C		80418,	81912,	GTPase-activating protein for yeast Rab family members  Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p  involved in the regulation of ER to Golgi vesicle transport
chrVI	82579	83875	82579	83875	+	STE2	YFL026W		82579,	83875,	Receptor for alpha-factor pheromone  seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
chrVI	84144	87234	84144	87234	-	BST1	YFL025C		84144,	87234,	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
chrVI	87846	90345	87846	90345	-	EPL1	YFL024C		87846,	90345,	Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex  homologous to Drosophila Enhancer of Polycomb
chrVI	90985	93376	90985	93376	+	BUD27	YFL023W		90985,	93376,	Unconventional prefoldin protein involved in translation initiation  mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor  diploid mutants show random budding
chrVI	93498	95010	93498	95010	-	FRS2	YFL022C		93498,	95010,	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme  evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
chrVI	95760	96615	95760	96615	-	YFL021C-A	YFL021C-A		95760,	96615,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVI	95965	97498	95965	97498	+	GAT1	YFL021W		95965,	97498,	Transcriptional activator of genes involved in nitrogen catabolite repression  contains a GATA-1-type zinc finger DNA-binding motif  activity and localization regulated by nitrogen limitation and Ure2p
chrVI	99230	99599	99230	99599	-	PAU5	YFL020C		99230,	99599,	Member of the seripauperin multigene family encoded mainly in subtelomeric regions  induced during alcoholic fermentation  induced by low temperature and also by anaerobic conditions  negatively regulated by oxygen and repressed by heme
chrVI	100251	100605	100251	100605	-	YFL019C	YFL019C		100251,	100605,	Dubious open reading frame unlikely to encode a protein  YFL019C is not an essential gene
chrVI	101627	103127	101627	103127	-	LPD1	YFL018C		101627,	103127,	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
chrVI	103698	103932	103698	103932	+	SMX2	YFL017W-A		103698,	103932,	Core Sm protein Sm G  part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs  homolog of human Sm G
chrVI	103982	104462	103982	104462	-	GNA1	YFL017C		103982,	104462,	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis  involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
chrVI	104700	106236	104700	106236	-	MDJ1	YFL016C		104700,	106236,	Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p  involved in protein folding/refolding in the mitochodrial matrix  required for proteolysis of misfolded proteins  member of the HSP40 (DnaJ) family of chaperones
chrVI	106414	106732	106414	106732	+	YFL015W-A	YFL015W-A		106414,	106732,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVI	106468	106963	106468	106963	-	YFL015C	YFL015C		106468,	106963,	Dubious open reading frame unlikely to encode a protein  partially overlaps dubious ORF YFL015W-A  YFL015C is not an essential gene
chrVI	107255	107585	107255	107585	+	HSP12	YFL014W		107255,	107585,	Plasma membrane protein involved in maintaining membrane organization in stress conditions  induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol  regulated by HOG and Ras-Pka pathways
chrVI	107798	108602	107798	108602	+	YFL013W-A	YFL013W-A		107798,	108602,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps IES1/YFL013C  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrVI	107851	109930	107851	109930	-	IES1	YFL013C		107851,	109930,	Subunit of the INO80 chromatin remodeling complex
chrVI	109809	110184	109809	110184	+	YFL012W-A	YFL012W-A		109809,	110184,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene IES1/YFL013C
chrVI	110646	111093	110646	111093	+	YFL012W	YFL012W		110646,	111093,	Putative protein of unknown function  transcribed during sporulation  null mutant exhibits increased resistance to rapamycin
chrVI	112344	113985	112344	113985	+	HXT10	YFL011W		112344,	113985,	Putative hexose transporter, expressed at low levels and expression is repressed by glucose
chrVI	114989	115274	114989	115274	+	AUA1	YFL010W-A		114989,	115274,	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
chrVI	115107	115743	115107	115743	-	WWM1	YFL010C		115107,	115743,	WW domain containing protein of unknown function  binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis  overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
chrVI	116144	118484	116144	118484	+	CDC4	YFL009W		116144,	118484,	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
chrVI	119428	123106	119428	123106	+	SMC1	YFL008W		119428,	123106,	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair  SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
chrVI	123478	129910	123478	129910	+	BLM10	YFL007W		123478,	129910,	Proteasome activator subunit  found in association with core particles, with and without the 19S regulatory particle  required for resistance to bleomycin, may be involved in protecting against oxidative damage  similar to mammalian PA200
chrVI	130333	130981	130333	130981	+	SEC4	YFL005W		130333,	130981,	Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy  associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
chrVI	131809	134296	131809	134296	+	VTC2	YFL004W		131809,	134296,	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
chrVI	134520	137157	134520	137157	-	MSH4	YFL003C		134520,	137157,	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
chrVI	138203	143517	138203	143517	+	YFL002W-A	YFL002W-A		138203,139497,	139496,143517,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVI	138203	139520	138203	139520	+	YFL002W-B	YFL002W-B		138203,	139520,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVI	145113	146934	145113	146934	-	SPB4	YFL002C		145113,	146934,	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway  sediments with 66S pre-ribosomes in sucrose gradients
chrVI	147130	148459	147130	148459	+	DEG1	YFL001W		147130,	148459,	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm  non-essential for viability
chrVI	149109	149724	149109	149724	+	LOC1	YFR001W		149109,	149724,	Nuclear protein involved in asymmetric localization of ASH1 mRNA  binds double-stranded RNA in vitro  constituent of 66S pre-ribosomal particles
chrVI	150015	152535	150015	152535	+	NIC96	YFR002W		150015,	152535,	Component of the nuclear pore complex, required for nuclear pore formation  forms a subcomplex with Nsp1p, Nup57p, and Nup49p
chrVI	152656	153124	152656	153124	-	YPI1	YFR003C		152656,	153124,	Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes  overproduction causes decreased cellular content of glycogen
chrVI	153392	154313	153392	154313	+	RPN11	YFR004W		153392,	154313,	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid  couples the deubiquitination and degradation of proteasome substrates  involved, independent of catalytic activity, in fission of mitochondria and peroxisomes
chrVI	154526	155873	154526	155873	-	SAD1	YFR005C		154526,	155873,	Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
chrVI	156144	157752	156144	157752	+	YFR006W	YFR006W		156144,	157752,	Putative X-Pro aminopeptidase  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YFR006W is not an essential gene
chrVI	159298	160360	159298	160360	+	YFH7	YFR007W		159298,	160360,	Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
chrVI	160534	161200	160534	161200	+	FAR7	YFR008W		160534,	161200,	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway  interacts with Far3p, Far8p, Far9p, Far10p, and Far11p
chrVI	162487	164746	162487	164746	+	GCN20	YFR009W		162487,	164746,	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p  proposed to stimulate Gcn2p activation by an uncharged tRNA
chrVI	163874	164132	163874	164132	+	YFR009W-A	YFR009W-A		163874,	164132,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene YFR009W  identified by expression profiling and mass spectrometry
chrVI	165066	166566	165066	166566	+	UBP6	YFR010W		165066,	166566,	Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains  works in opposition to Hul5p polyubiquitin elongation activity  mutant has aneuploidy tolerance
chrVI	166727	166916	166727	166916	+	YFR010W-A	YFR010W-A		166727,	166916,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the uncharacterized gene YFR011C  identified by expression profiling and mass spectrometry
chrVI	166745	167258	166745	167258	-	AIM13	YFR011C		166745,	167258,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria  null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss
chrVI	167887	168496	167887	168496	+	YFR012W	YFR012W		167887,	168496,	Putative protein of unknown function
chrVI	169223	169310	169223	169310	+	YFR012W-A	YFR012W-A		169223,	169310,	Putative protein of unknown function  identified by homology
chrVI	169921	172285	169921	172285	+	IOC3	YFR013W		169921,	172285,	Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome  has homology to Esc8p, which is involved in silencing
chrVI	172536	173877	172536	173877	-	CMK1	YFR014C		172536,	173877,	Calmodulin-dependent protein kinase  may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
chrVI	174264	176391	174264	176391	-	GSY1	YFR015C		174264,	176391,	Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog  expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
chrVI	177041	180743	177041	180743	-	YFR016C	YFR016C		177041,	180743,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud  interacts with Spa2p  YFL016C is not an essential gene
chrVI	182273	182861	182273	182861	-	YFR017C	YFR017C		182273,	182861,	Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity  required for normal intracellular accumulation of glycogen  phosphorylated in vivo  expression increases during wine fermentation
chrVI	183130	184222	183130	184222	-	YFR018C	YFR018C		183130,	184222,	Putative protein of unknown function
chrVI	184501	191338	184501	191338	+	FAB1	YFR019W		184501,	191338,	1-phosphatidylinositol-3-phosphate 5-kinase  vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
chrVI	192736	193435	192736	193435	+	YFR020W	YFR020W		192736,	193435,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVI	194811	196314	194811	196314	+	ATG18	YFR021W		194811,	196314,	Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway  binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate  WD-40 repeat protein
chrVI	196832	199034	196832	199034	+	ROG3	YFR022W		196832,	199034,	Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs  has similarity to Rod1p  mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant  proposed to regulate the endocytosis of plasma membrane proteins
chrVI	199873	201709	199873	201709	+	PES4	YFR023W		199873,	201709,	Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
chrVI	201959	203433	201959	203433	-	LSB3	YFR024C-A		201959,203386,	203292,203433,	Protein containing a C-terminal SH3 domain  binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
chrVI	203742	204750	203742	204750	-	HIS2	YFR025C		203742,	204750,	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis  mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts  transcription is regulated by general amino acid control
chrVI	205747	206257	205747	206257	-	ULI1	YFR026C		205747,	206257,	Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
chrVI	207451	208297	207451	208297	+	ECO1	YFR027W		207451,	208297,	Acetyltransferase required for establishment of sister chromatid cohesion  modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks  has a C2H2-type zinc finger  mutations in human homolog ESCO2 cause Roberts syndrome
chrVI	208412	210068	208412	210068	-	CDC14	YFR028C		208412,	210068,	Protein phosphatase required for mitotic exit  located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit  required for meiosis I spindle disassembly  released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II  maintained in nucleolus by Cdc55p in early meiosis
chrVI	210936	212973	210936	212973	+	PTR3	YFR029W		210936,	212973,	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
chrVI	213311	216419	213311	216419	+	MET10	YFR030W		213311,	216419,	Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
chrVI	216593	220106	216593	220106	-	SMC2	YFR031C		216593,	220106,	Subunit of the condensin complex  essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase  Smc2p/Smc4p complex binds DNA  required for clustering of tRNA genes at the nucleolus
chrVI	220506	221418	220506	221418	-	RPL2A	YFR031C-A		220506,221414,	221267,221418,	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
chrVI	222089	222959	222089	222959	-	RRT5	YFR032C		222089,	222959,	Putative protein of unknown function  non-essential gene identified in a screen for mutants with increased levels of rDNA transcription  expressed at high levels during sporulation
chrVI	223257	223437	223257	223437	-	RPL29	YFR032C-A		223257,	223437,	Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein  not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
chrVI	223709	223973	223709	223973	-	YFR032C-B	YFR032C-B		223709,	223973,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVI	224325	224769	224325	224769	-	QCR6	YFR033C		224325,	224769,	Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain  highly acidic protein  required for maturation of cytochrome c1
chrVI	225019	225958	225019	225958	-	PHO4	YFR034C		225019,	225958,	Basic helix-loop-helix (bHLH) transcription factor of the myc-family  activates transcription cooperatively with Pho2p in response to phosphate limitation  binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,  function is regulated by phosphorylation at multiple sites and by phosphate availability
chrVI	226021	226309	226021	226309	+	YFR034W-A	YFR034W-A		226021,	226309,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps YFR035C  identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
chrVI	226120	226465	226120	226465	-	YFR035C	YFR035C		226120,	226465,	Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
chrVI	226962	227337	226962	227337	+	CDC26	YFR036W		226962,	227337,	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
chrVI	227450	228101	227450	228101	+	YFR036W-A	YFR036W-A		227450,	228101,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene RSC8
chrVI	227512	229186	227512	229186	-	RSC8	YFR037C		227512,	229186,	Component of the RSC chromatin remodeling complex  essential for viability and mitotic growth  homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
chrVI	229379	231941	229379	231941	+	IRC5	YFR038W		229379,	231941,	Putative ATPase containing the DEAD/H helicase-related sequence motif  null mutant displays increased levels of spontaneous Rad52p foci
chrVI	232011	233544	232011	233544	-	YFR039C	YFR039C		232011,	233544,	Putative protein of unknown function  may be involved in response to high salt and changes in carbon source  deletion mutant has decreased spore survival in Drosophila feces
chrVI	234241	237250	234241	237250	+	SAP155	YFR040W		234241,	237250,	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function  member of a family of similar proteins including Sap4p, Sap185p, and Sap190p
chrVI	237367	238255	237367	238255	-	ERJ5	YFR041C		237367,	238255,	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum  loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
chrVI	238457	239060	238457	239060	+	KEG1	YFR042W		238457,	239060,	Integral membrane protein of the ER  physically interacts with Kre6p  has a role in the synthesis of beta-1,6-glucan in the cell wall  required for cell viability
chrVI	239113	239827	239113	239827	-	IRC6	YFR043C		239113,	239827,	Putative protein of unknown function  null mutant displays increased levels of spontaneous Rad52p foci
chrVI	239991	241437	239991	241437	-	DUG1	YFR044C		239991,	241437,	Cys-Gly metallo-di-peptidase  forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
chrVI	241997	242999	241997	242999	+	YFR045W	YFR045W		241997,242081,	242009,242999,	Putative mitochondrial transport protein  null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
chrVI	243073	244159	243073	244159	-	CNN1	YFR046C		243073,	244159,	Kinetochore protein of unknown function  associated with the essential kinetochore proteins Nnf1p and Spc24p  phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.
chrVI	244278	245166	244278	245166	-	BNA6	YFR047C		244278,	245166,	Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine  expression regulated by Hst1p
chrVI	246145	248134	246145	248134	+	RMD8	YFR048W		246145,	248134,	Cytosolic protein required for sporulation
chrVI	248522	248894	248522	248894	+	YMR31	YFR049W		248522,	248894,	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
chrVI	249065	249866	249065	249866	-	PRE4	YFR050C		249065,	249866,	Beta 7 subunit of the 20S proteasome
chrVI	250162	251803	250162	251803	-	RET2	YFR051C		250162,	251803,	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles  involved in retrograde transport between Golgi and ER
chrVI	252504	253329	252504	253329	+	RPN12	YFR052W		252504,	253329,	Subunit of the 19S regulatory particle of the 26S proteasome lid  synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle  physically interacts with Nob1p and Rpn3p
chrVI	253428	253734	253428	253734	-	YFR052C-A	YFR052C-A		253428,	253734,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVI	253591	255049	253591	255049	-	HXK1	YFR053C		253591,	255049,	Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism  expression is highest during growth on non-glucose carbon sources  glucose-induced repression involves the hexokinase Hxk2p
chrVI	258854	259433	258854	259433	-	YFR054C	YFR054C		258854,	259433,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVI	263956	264325	263956	264325	-	YFR056C	YFR056C		263956,	264325,	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data  partially overlaps the uncharacterized gene YFR055W
chrVI	264203	265226	264203	265226	+	IRC7	YFR055W		264203,	265226,	Beta-lyase involved in the production of thiols  null mutant displays increased levels of spontaneous Rad52p foci  expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
chrVI	269060	269516	269060	269516	+	YFR057W	YFR057W		269060,	269516,	Putative protein of unknown function
chrVII	2789	3932	2789	3932	+	COS12	YGL263W		2789,	3932,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrVII	5311	5839	5311	5839	+	YGL262W	YGL262W		5311,	5839,	Putative protein of unknown function  null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein  YGL262W is not an essential gene
chrVII	6289	6652	6289	6652	-	PAU11	YGL261C		6289,	6652,	Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions  mRNA expression appears to be regulated by SUT1 and UPC2
chrVII	6859	7090	6859	7090	+	YGL260W	YGL260W		6859,	7090,	Putative protein of unknown function  transcription is significantly increased in a NAP1 deletion background  deletion mutant has increased accumulation of nickel and selenium
chrVII	8469	8967	8469	8967	+	YPS5	YGL259W		8469,	8967,	Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
chrVII	9161	9395	9161	9395	+	YGL258W-A	YGL258W-A		9161,	9395,	Putative protein of unknown function
chrVII	11109	11730	11109	11730	+	VEL1	YGL258W		11109,	11730,	Protein of unknown function  highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
chrVII	12480	14157	12480	14157	-	MNT2	YGL257C		12480,	14157,	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
chrVII	15158	16307	15158	16307	+	ADH4	YGL256W		15158,	16307,	Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases  transcription is induced in response to zinc deficiency
chrVII	20977	22108	20977	22108	+	ZRT1	YGL255W		20977,	22108,	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake  transcription is induced under low-zinc conditions by the Zap1p transcription factor
chrVII	22303	23203	22303	23203	+	FZF1	YGL254W		22303,	23203,	Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers
chrVII	23934	25395	23934	25395	+	HXK2	YGL253W		23934,	25395,	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol  predominant hexokinase during growth on glucose  functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
chrVII	25717	27484	25717	27484	-	RTG2	YGL252C		25717,	27484,	Sensor of mitochondrial dysfunction  regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways  Rtg2p is inhibited by the phosphorylated form of Mks1p
chrVII	27920	31636	27920	31636	-	HFM1	YGL251C		27920,31578,	31426,31636,	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control  catalyzes the unwinding of Holliday junctions  has ssDNA and dsDNA stimulated ATPase activity
chrVII	31909	32635	31909	32635	+	RMR1	YGL250W		31909,	32635,	Protein required for meiotic recombination and gene conversion  null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media  GFP-fusion protein localizes to both cytoplasm and nucleus
chrVII	33097	35212	33097	35212	+	ZIP2	YGL249W		33097,	35212,	Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis
chrVII	35652	36762	35652	36762	+	PDE1	YGL248W		35652,	36762,	Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway  glucose induces transcription and inhibits translation
chrVII	36932	37526	36932	37526	+	BRR6	YGL247W		36932,	37526,	Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export  exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
chrVII	37616	38780	37616	38780	-	RAI1	YGL246C		37616,	38780,	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures  binds to and stabilizes the exoribonuclease Rat1p  required for pre-rRNA processing  homologous to human DOM3Z
chrVII	39022	41149	39022	41149	+	GUS1	YGL245W		39022,	41149,	Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p  complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
chrVII	41497	43174	41497	43174	+	RTF1	YGL244W		41497,	43174,	Subunit of the RNA polymerase II-associated Paf1 complex  directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements  involved in telomere maintenance  involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
chrVII	43306	44509	43306	44509	+	TAD1	YGL243W		43306,	44509,	tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
chrVII	44651	45197	44651	45197	-	YGL242C	YGL242C		44651,	45197,	Putative protein of unknown function  deletion mutant is viable
chrVII	45444	48459	45444	48459	+	KAP114	YGL241W		45444,	48459,	Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p  amino terminus shows similarity to those of other importins, particularly Cse1p  localization is primarily nuclear
chrVII	48612	49365	48612	49365	+	DOC1	YGL240W		48612,	49365,	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition  involved in cyclin proteolysis  contains a conserved DOC1 homology domain
chrVII	49430	49745	49430	49745	-	YGL239C	YGL239C		49430,	49745,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene CSE1
chrVII	49551	52434	49551	52434	+	CSE1	YGL238W		49551,	52434,	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
chrVII	52730	53528	52730	53528	-	HAP2	YGL237C		52730,	53528,	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression  contains sequences sufficient for both complex assembly and DNA binding
chrVII	53786	55796	53786	55796	-	MTO1	YGL236C		53786,	55796,	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs  required for respiration in paromomycin-resistant 15S rRNA mutants
chrVII	55278	55815	55278	55815	+	YGL235W	YGL235W		55278,	55815,	Putative protein of unknown function  potential Cdc28p substrate  null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
chrVII	56481	58890	56481	58890	+	ADE5,7	YGL234W		56481,	58890,	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
chrVII	59121	61854	59121	61854	+	SEC15	YGL233W		59121,	61854,	Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis  Sec15p associates with Sec4p and vesicles
chrVII	62074	63002	62074	63002	+	TAN1	YGL232W		62074,62189,	62131,63002,	Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA
chrVII	63047	63620	63047	63620	-	EMC4	YGL231C		63047,	63620,	Member of a transmembrane complex required for efficient folding of proteins in the ER  null mutant displays induction of the unfolded protein response  human ortholog TMEM85 may function in apoptosis
chrVII	63771	64215	63771	64215	-	YGL230C	YGL230C		63771,	64215,	Putative protein of unknown function  non-essential gene
chrVII	64502	66959	64502	66959	-	SAP4	YGL229C		64502,	66959,	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
chrVII	67597	69331	67597	69331	+	SHE10	YGL228W		67597,	69331,	Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function  overexpression causes growth arrest
chrVII	69670	72547	69670	72547	+	VID30	YGL227W		69670,	72547,	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase)  binds FBPase  shifts the balance of nitrogen metabolism toward glutamate production  localizes to the nucleus and the cytoplasm
chrVII	72748	73158	72748	73158	-	OST5	YGL226C-A		72748,73137,	72988,73158,	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
chrVII	73339	73711	73339	73711	+	MTC3	YGL226W		73339,	73711,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion  mtc3 is synthetically sick with cdc13-1
chrVII	76893	77907	76893	77907	+	VRG4	YGL225W		76893,	77907,	Golgi GDP-mannose transporter  regulates Golgi function and glycosylation in Golgi
chrVII	78014	78857	78014	78857	-	SDT1	YGL224C		78014,	78857,	Pyrimidine nucleotidase  overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
chrVII	79111	80365	79111	80365	-	COG1	YGL223C		79111,	80365,	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrVII	80658	81186	80658	81186	-	EDC1	YGL222C		80658,	81186,	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p  has a role in translation during heat stress
chrVII	81425	82292	81425	82292	-	NIF3	YGL221C		81425,	82292,	Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product)  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	82373	82736	82373	82736	+	FRA2	YGL220W		82373,	82736,	Protein involved in negative regulation of transcription of iron regulon  forms an iron independent complex with Fra2p, Grx3p, and Grx4p  null mutant fails to repress iron regulon and is sensitive to nickel
chrVII	82877	84257	82877	84257	-	MDM34	YGL219C		82877,	84257,	Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
chrVII	83649	84300	83649	84300	+	YGL218W	YGL218W		83649,	84300,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  93% of ORF overlaps the verified gene MDM34  deletion in cyr1 mutant results in loss of stress resistance
chrVII	84838	85180	84838	85180	-	YGL217C	YGL217C		84838,	85180,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF KIP3/YGL216W
chrVII	84884	87302	84884	87302	+	KIP3	YGL216W		84884,	87302,	Kinesin-related motor protein involved in mitotic spindle positioning
chrVII	87980	89339	87980	89339	+	CLG1	YGL215W		87980,	89339,	Cyclin-like protein that interacts with Pho85p  has sequence similarity to G1 cyclins PCL1 and PCL2
chrVII	90009	90495	90009	90495	+	YGL214W	YGL214W		90009,	90495,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C
chrVII	90053	91247	90053	91247	-	SKI8	YGL213C		90053,	91247,	Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome  also required for meiotic double-strand break recombination  null mutants have superkiller phenotype
chrVII	91431	92382	91431	92382	+	VAM7	YGL212W		91431,	92382,	Vacuolar SNARE protein that functions with Vam3p in vacuolar protein trafficking  has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding  SNAP-25 homolog
chrVII	92511	93591	92511	93591	+	NCS6	YGL211W		92511,	93591,	Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs  has a role in urmylation and in invasive and pseudohyphal growth  inhibits replication of Brome mosaic virus in S. cerevisiae
chrVII	93791	94460	93791	94460	+	YPT32	YGL210W		93791,	94460,	Rab family GTPase, very similar to Ypt31p  involved in the exocytic pathway  mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
chrVII	95857	97006	95857	97006	+	MIG2	YGL209W		95857,	97006,	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose  binds to Mig1p-binding sites in SUC2 promoter
chrVII	97337	98585	97337	98585	+	SIP2	YGL208W		97337,	98585,	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation  null mutants exhibit accelerated aging  N-myristoylprotein localized to the cytoplasm and the plasma membrane
chrVII	98968	102076	98968	102076	+	SPT16	YGL207W		98968,	102076,	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases
chrVII	102542	107504	102542	107504	-	CHC1	YGL206C		102542,	107504,	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis  two heavy chains form the clathrin triskelion structural component  the light chain (CLC1) is thought to regulate function
chrVII	108157	110404	108157	110404	+	POX1	YGL205W		108157,	110404,	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway  localized to the peroxisomal matrix
chrVII	111699	112005	111699	112005	-	YGL204C	YGL204C		111699,	112005,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	112474	114664	112474	114664	-	KEX1	YGL203C		112474,	114664,	Protease involved in the processing of killer toxin and alpha factor precursor  cleaves Lys and Arg residues from the C-terminus of peptides and proteins
chrVII	116058	117561	116058	117561	+	ARO8	YGL202W		116058,	117561,	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
chrVII	117853	120907	117853	120907	-	MCM6	YGL201C		117853,	120907,	Protein involved in DNA replication  component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex  forms a subcomplex with Mcm4p and Mcm7p
chrVII	122693	123305	122693	123305	-	EMP24	YGL200C		122693,	123305,	Component of the p24 complex  binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi  integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
chrVII	123571	124042	123571	124042	-	YGL199C	YGL199C		123571,	124042,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YIP4/YGL198W
chrVII	123590	124298	123590	124298	+	YIP4	YGL198W		123590,	124298,	Protein that interacts with Rab GTPases, localized to late Golgi vesicles  computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
chrVII	124697	129161	124697	129161	+	MDS3	YGL197W		124697,	129161,	Putative component of the TOR regulatory pathway  negative regulator of early meiotic gene expression  required, with Pmd1p, for growth under alkaline conditions  has an N-terminal kelch-like domain
chrVII	129882	131169	129882	131169	+	DSD1	YGL196W		129882,	131169,	D-serine dehydratase (aka D-serine ammonia-lyase)  converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc  may play a role in D-serine detoxification  L-serine is not a substrate
chrVII	131524	139543	131524	139543	+	GCN1	YGL195W		131524,	139543,	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p  proposed to stimulate Gcn2p activation by an uncharged tRNA
chrVII	139718	139961	139718	139961	-	YGL194C-A	YGL194C-A		139718,	139961,	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
chrVII	140367	141726	140367	141726	-	HOS2	YGL194C		140367,	141726,	Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails  subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
chrVII	141915	142227	141915	142227	-	YGL193C	YGL193C		141915,	142227,	Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
chrVII	142245	144048	142245	144048	+	IME4	YGL192W		142245,	144048,	Probable mRNA N6-adenosine methyltransferase required for entry into meiosis  transcribed in diploid cells  haploids repress IME4 transcription via production of antisense IME4 transcripts  antisense transcription is repressed in diploids
chrVII	144807	145197	144807	145197	+	COX13	YGL191W		144807,	145197,	Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
chrVII	145808	147389	145808	147389	-	CDC55	YGL190C		145808,	147389,	Non-essential regulatory subunit B of protein phosphatase 2A (PP2A)  involved in regulation of mitotic exit  required for correct nuclear division and chromosome segregation in meiosis  maintains sequestration of the phosphatase Cdc14p in nucleolus during early meiosis, which is essential for meiosis I spindle assembly  limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion  found in nucleus, bud neck and bud of most cells
chrVII	148228	148588	148228	148588	-	RPS26A	YGL189C		148228,	148588,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
chrVII	148823	148964	148823	148964	-	YGL188C-A	YGL188C-A		148823,	148964,	Putative protein of unknown function
chrVII	149342	149516	149342	149516	-	YGL188C	YGL188C		149342,	149516,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	149703	150171	149703	150171	-	COX4	YGL187C		149703,	150171,	Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain  precursor N-terminal 25 residues are cleaved during mitochondrial import  phosphorylated  spermidine enhances translation
chrVII	151036	152776	151036	152776	-	TPN1	YGL186C		151036,	152776,	Plasma membrane pyridoxine (vitamin B6) transporter  member of the purine-cytosine permease subfamily within the major facilitator superfamily  proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
chrVII	153166	154306	153166	154306	-	YGL185C	YGL185C		153166,	154306,	Putative protein with sequence similarity to hydroxyacid dehydrogenases  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrVII	154614	156012	154614	156012	-	STR3	YGL184C		154614,	156012,	Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine  may be redox regulated by Gto1p
chrVII	156542	157285	156542	157285	-	MND1	YGL183C		156542,157282,	157199,157285,	Protein required for recombination and meiotic nuclear division  forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
chrVII	157272	157596	157272	157596	-	YGL182C	YGL182C		157272,	157596,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF MND1/YGL183C
chrVII	157905	159096	157905	159096	+	GTS1	YGL181W		157905,	159096,	Protein involved in Arf3p regulation and in transcription regulation  localizes to the nucleus and to endocytic patches  contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain  gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis  expression oscillates in a pattern similar to metabolic oscillations
chrVII	160064	162758	160064	162758	+	ATG1	YGL180W		160064,	162758,	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway  structurally required for phagophore assembly site formation  during autophagy forms a complex with Atg13p and Atg17p
chrVII	163408	165091	163408	165091	-	TOS3	YGL179C		163408,	165091,	Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p  functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
chrVII	167351	170571	167351	170571	+	MPT5	YGL178W		167351,167994,	167354,170571,	Member of the Puf family of RNA-binding proteins  binds to mRNAs encoding chromatin modifiers and spindle pole body components  involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
chrVII	167558	167906	167558	167906	+	YGL177W	YGL177W		167558,	167906,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	171414	173079	171414	173079	-	YGL176C	YGL176C		171414,	173079,	Putative protein of unknown function  deletion mutant is viable and has no detectable phenotype
chrVII	173284	174322	173284	174322	-	SAE2	YGL175C		173284,	174322,	Endonuclease that processes hairpin DNA structures with the MRX complex  involved in meiotic and mitotic double-strand break repair  phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
chrVII	174544	175345	174544	175345	+	BUD13	YGL174W		174544,	175345,	Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing  involved in bud-site selection  diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern
chrVII	175526	180113	175526	180113	-	KEM1	YGL173C		175526,	180113,	Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay  plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
chrVII	180699	182118	180699	182118	+	NUP49	YGL172W		180699,	182118,	Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
chrVII	182389	184084	182389	184084	+	ROK1	YGL171W		182389,	184084,	ATP-dependent RNA helicase of the DEAD box family  required for 18S rRNA synthesis
chrVII	184152	185394	184152	185394	-	SPO74	YGL170C		184152,	185394,	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
chrVII	186058	187339	186058	187339	+	SUA5	YGL169W		186058,	187339,	Single-stranded telomeric DNA-binding protein, required for normal telomere length  null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA  member of conserved YrdC/Sua5 family
chrVII	187463	187796	187463	187796	+	HUR1	YGL168W		187463,	187796,	Protein of unknown function  reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
chrVII	187615	190468	187615	190468	-	PMR1	YGL167C		187615,	190468,	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi  involved in Ca2+ dependent protein sorting and processing  mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
chrVII	191128	191806	191128	191806	+	CUP2	YGL166W		191128,	191806,	Copper-binding transcription factor  activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
chrVII	191397	191976	191397	191976	-	YGL165C	YGL165C		191397,	191976,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF CUP2/YGL166W
chrVII	191977	193300	191977	193300	-	YRB30	YGL164C		191977,	193300,	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p)  shares similarity to proteins in other fungi but not in higher eukaryotes
chrVII	193706	196403	193706	196403	-	RAD54	YGL163C		193706,	196403,	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA  involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis  member of the SWI/SNF family
chrVII	198137	199037	198137	199037	+	SUT1	YGL162W		198137,	199037,	Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake  involved in induction of hypoxic gene expression
chrVII	199209	200142	199209	200142	-	YIP5	YGL161C		199209,	200142,	Protein that interacts with Rab GTPases, localized to late Golgi vesicles  computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
chrVII	200560	202273	200560	202273	+	AIM14	YGL160W		200560,	202273,	Protein with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis  may interact with ribosomes  null mutant displays elevated frequency of mitochondrial genome loss
chrVII	202720	203833	202720	203833	+	YGL159W	YGL159W		202720,	203833,	Putative protein of unknown function  deletion mutant has no detectable phenotype
chrVII	207032	208571	207032	208571	+	RCK1	YGL158W		207032,	208571,	Protein kinase involved in the response to oxidative stress  identified as suppressor of S. pombe cell cycle checkpoint mutations
chrVII	209005	210049	209005	210049	+	ARI1	YGL157W		209005,	210049,	NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates  member of the short-chain dehydrogenase/reductase superfamily
chrVII	210415	213667	210415	213667	+	AMS1	YGL156W		210415,	213667,	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation  delivered to the vacuole in a novel pathway separate from the secretory pathway
chrVII	214080	215211	214080	215211	+	CDC43	YGL155W		214080,	215211,	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe  has substrates important for morphogenesis
chrVII	215277	216096	215277	216096	-	LYS5	YGL154C		215277,	216096,	Phosphopantetheinyl transferase involved in lysine biosynthesis  converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
chrVII	216272	217298	216272	217298	+	PEX14	YGL153W		216272,	217298,	Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery  interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
chrVII	216691	217369	216691	217369	-	YGL152C	YGL152C		216691,	217369,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF PEX14/YGL153W
chrVII	217523	220922	217523	220922	+	NUT1	YGL151W		217523,	220922,	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
chrVII	221103	225573	221103	225573	-	INO80	YGL150C		221103,	225573,	ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro  has a role in modulating stress gene transcription
chrVII	225571	225877	225571	225877	+	YGL149W	YGL149W		225571,	225877,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF INO80/YGL150C.
chrVII	226398	227529	226398	227529	+	ARO2	YGL148W		226398,	227529,	Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
chrVII	227753	228329	227753	228329	-	RPL9A	YGL147C		227753,	228329,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
chrVII	228750	229686	228750	229686	-	RRT6	YGL146C		228750,	229686,	Putative protein of unknown function  non-essential gene identified in a screen for mutants with increased levels of rDNA transcription  contains two putative transmembrane spans, but no significant homology to other known proteins
chrVII	230242	232348	230242	232348	+	TIP20	YGL145W		230242,	232348,	Peripheral membrane protein required for fusion of COPI vesicles with the ER  prohibits back-fusion of COPII vesicles with the ER  forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
chrVII	232449	234507	232449	234507	-	ROG1	YGL144C		232449,	234507,	Protein with putative serine active lipase domain
chrVII	234716	235958	234716	235958	-	MRF1	YGL143C		234716,	235958,	Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation  lack of MRF1 causes mitochondrial genome instability
chrVII	236268	238119	236268	238119	-	GPI10	YGL142C		236268,	238119,	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis  putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure  human PIG-Bp is a functional homolog
chrVII	238352	241085	238352	241085	+	HUL5	YGL141W		238352,	241085,	Multiubiquitin chain assembly factor (E4)  proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease  required for retrograde transport of misfolded proteins during ERAD
chrVII	241352	245012	241352	245012	-	YGL140C	YGL140C		241352,	245012,	Putative protein of unknown function  non-essential gene  contains multiple predicted transmembrane domains
chrVII	245715	248124	245715	248124	+	FLC3	YGL139W		245715,	248124,	Putative FAD transporter, similar to Flc1p and Flc2p  localized to the ER
chrVII	248493	249531	248493	249531	-	YGL138C	YGL138C		248493,	249531,	Putative protein of unknown function  has no significant sequence similarity to any known protein
chrVII	249868	252738	249868	252738	+	SEC27	YGL137W		249868,250086,	249886,252738,	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport  contains WD40 domains that mediate cargo selective interactions  45% sequence identity to mammalian beta'-COP
chrVII	252896	253859	252896	253859	-	MRM2	YGL136C		252896,	253859,	Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA  MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA  has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
chrVII	254640	255294	254640	255294	+	RPL1B	YGL135W		254640,	255294,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins  rpl1a rpl1b double null mutation is lethal
chrVII	255662	256964	255662	256964	+	PCL10	YGL134W		255662,	256964,	Pho85p cyclin  recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
chrVII	257706	261501	257706	261501	+	ITC1	YGL133W		257706,	261501,	Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1  similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
chrVII	261579	261915	261579	261915	+	YGL132W	YGL132W		261579,	261915,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene SNT2/YGL131C
chrVII	261647	265859	261647	265859	-	SNT2	YGL131C		261647,	265859,	DNA binding protein with similarity to the S. pombe Snt2 protein  computational analysis suggests a role in regulation of expression of genes encoding amine transporters
chrVII	266144	267524	266144	267524	+	CEG1	YGL130W		266144,	267524,	Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA  the mammalian enzyme is a single bifunctional polypeptide
chrVII	267722	269075	267722	269075	-	RSM23	YGL129C		267722,	269075,	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins  null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
chrVII	269292	270144	269292	270144	-	CWC23	YGL128C		269292,	270144,	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing  has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
chrVII	270391	270775	270391	270775	-	SOH1	YGL127C		270391,	270775,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  involved in telomere maintenance  conserved with other metazoan MED31 subunits
chrVII	270996	272139	270996	272139	+	SCS3	YGL126W		270996,	272139,	Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis  disputed role in the synthesis of inositol phospholipids from inositol
chrVII	272519	274322	272519	274322	+	MET13	YGL125W		272519,	274322,	Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
chrVII	274779	276714	274779	276714	-	MON1	YGL124C		274779,	276714,	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole  associates, as a complex with Ccz1p, with a perivacuolar compartment  potential Cdc28p substrate
chrVII	277616	278381	277616	278381	+	RPS2	YGL123W		277616,	278381,	Protein component of the small (40S) subunit, essential for control of translational accuracy  phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy  methylated on one or more arginine residues by Hmt1p
chrVII	277633	277864	277633	277864	-	YGL123C-A	YGL123C-A		277633,	277864,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene RPS2/YGL123W
chrVII	278945	280523	278945	280523	-	NAB2	YGL122C		278945,	280523,	Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control  binds nuclear pore protein Mlp1p  autoregulates mRNA levels  related to human hnRNPs  nuclear localization sequence binds Kap104p
chrVII	280776	281157	280776	281157	-	GPG1	YGL121C		280776,	281157,	Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p  involved in regulation of pseudohyphal growth  requires Gpb1p or Gpb2p to interact with Gpa2p  overproduction causes prion curing
chrVII	281633	283937	281633	283937	-	PRP43	YGL120C		281633,	283937,	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
chrVII	284441	285947	284441	285947	+	COQ8	YGL119W		284441,	285947,	Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth  exhibits genetic interaction with COQ9, suggesting a common function  similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis
chrVII	288013	288451	288013	288451	-	YGL118C	YGL118C		288013,	288451,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	288511	289309	288511	289309	+	YGL117W	YGL117W		288511,	289309,	Putative protein of unknown function
chrVII	289808	291641	289808	291641	+	CDC20	YGL116W		289808,	291641,	Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition  directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors  potential Cdc28p substrate
chrVII	292032	293001	292032	293001	+	SNF4	YGL115W		292032,	293001,	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member)  activates glucose-repressed genes, represses glucose-induced genes  role in sporulation, and peroxisome biogenesis
chrVII	293459	295637	293459	295637	+	YGL114W	YGL114W		293459,	295637,	Putative protein of unknown function  predicted member of the oligopeptide transporter (OPT) family of membrane transporters
chrVII	295931	297938	295931	297938	+	SLD3	YGL113W		295931,	297938,	Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication  interacts with Cdc45p
chrVII	298177	299728	298177	299728	-	TAF6	YGL112C		298177,	299728,	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
chrVII	299977	301369	299977	301369	+	NSA1	YGL111W		299977,	301369,	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
chrVII	301536	303411	301536	303411	-	CUE3	YGL110C		301536,	303411,	Protein of unknown function  has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
chrVII	303512	303836	303512	303836	+	YGL109W	YGL109W		303512,	303836,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the uncharacterized gene YGL108C
chrVII	303648	304071	303648	304071	-	YGL108C	YGL108C		303648,	304071,	Protein of unknown function, predicted to be palmitoylated  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
chrVII	304332	306273	304332	306273	-	RMD9	YGL107C		304332,	306273,	Mitochondrial protein required for respiratory growth  mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes  located on matrix face of the inner membrane and loosely associated with mitoribosomes
chrVII	306559	307009	306559	307009	+	MLC1	YGL106W		306559,	307009,	Essential light chain for Myo1p, light chain for Myo2p  stabilizes Myo2p by binding to the neck region  interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
chrVII	307436	308567	307436	308567	+	ARC1	YGL105W		307436,	308567,	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm  also binds quadruplex nucleic acids
chrVII	308712	310173	308712	310173	-	VPS73	YGL104C		308712,	310173,	Mitochondrial protein  mutation affects vacuolar protein sorting  putative transporter  member of the sugar porter family
chrVII	310966	311927	310966	311927	+	RPL28	YGL103W		310966,311526,	311015,311927,	Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins  may have peptidyl transferase activity  can mutate to cycloheximide resistance
chrVII	311504	311933	311504	311933	-	YGL102C	YGL102C		311504,	311933,	Dubious open reading frame unlikely to encode a functional protein  overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
chrVII	312192	312840	312192	312840	+	YGL101W	YGL101W		312192,	312840,	Putative protein of unknown function  non-essential gene with similarity to YBR242W  interacts with the DNA helicase Hpr5p
chrVII	313233	314283	313233	314283	+	SEH1	YGL100W		313233,	314283,	Nuclear pore protein of the conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p)  part of the SEA (Seh1-associated) complex, a coatamer-related complex that associates dynamically with the vacuole  homologous to Sec13p  the Nup84 subcomplex has a role in transcription elongation
chrVII	314630	316553	314630	316553	+	LSG1	YGL099W		314630,	316553,	Putative GTPase involved in 60S ribosomal subunit biogenesis  required for the release of Nmd3p from 60S subunits in the cytoplasm
chrVII	317341	318079	317341	318079	+	USE1	YGL098W		317341,	318079,	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER  forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
chrVII	321781	323230	321781	323230	+	SRM1	YGL097W		321781,	323230,	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules  suppressor of the pheromone response pathway  potentially phosphorylated by Cdc28p
chrVII	325330	326161	325330	326161	+	TOS8	YGL096W		325330,	326161,	Homeodomain-containing protein and putative transcription factor found associated with chromatin  target of SBF transcription factor  induced during meiosis and under cell-damaging conditions  similar to Cup9p transcription factor
chrVII	328873	330607	328873	330607	-	VPS45	YGL095C		328873,	330607,	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting  required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p  essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
chrVII	331117	334465	331117	334465	-	PAN2	YGL094C		331117,	334465,	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
chrVII	334885	337639	334885	337639	+	SPC105	YGL093W		334885,	337639,	Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors  required for sister chromatid bi-orientation and kinetochore binding of SAC components
chrVII	337905	341859	337905	341859	+	NUP145	YGL092W		337905,	341859,	Essential nucleoporin, subunit of the Nup84p subcomplex  catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p  the Nup84 subcomplex has a role in transcription elongation
chrVII	342055	343042	342055	343042	-	NBP35	YGL091C		342055,	343042,	Essential iron-sulfur cluster binding protein localized in the cytoplasm  forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol  similar to P-loop NTPases
chrVII	343318	344584	343318	344584	+	LIF1	YGL090W		343318,	344584,	Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair  physically interacts with Dnl4p and Nej1p  homologous to mammalian XRCC4 protein
chrVII	344790	345153	344790	345153	-	MF(ALPHA)2	YGL089C		344790,	345153,	Mating pheromone alpha-factor, made by alpha cells  interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating  also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
chrVII	345835	346201	345835	346201	+	YGL088W	YGL088W		345835,	346201,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps snR10, a snoRNA required for preRNA processing
chrVII	346405	346904	346405	346904	-	MMS2	YGL087C		346405,346893,	346808,346904,	Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair  forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme  cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p
chrVII	347118	349368	347118	349368	+	MAD1	YGL086W		347118,	349368,	Coiled-coil protein involved in the spindle-assembly checkpoint  phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex  forms a complex with Mad2p
chrVII	349615	350440	349615	350440	+	LCL3	YGL085W		349615,	350440,	Putative protein of unknown function  mutant has long chronological lifespan  has homology to Staphylococcus aureus nuclease  GFP-fusion protein localizes to mitochondria  is induced in response to the DNA-damaging agent MMS
chrVII	350615	352298	350615	352298	-	GUP1	YGL084C		350615,	352298,	Plasma membrane protein involved in remodeling GPI anchors  member of the MBOAT family of putative membrane-bound O-acyltransferases  proposed to be involved in glycerol transport
chrVII	353057	355472	353057	355472	+	SCY1	YGL083W		353057,	355472,	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
chrVII	355826	356972	355826	356972	+	YGL082W	YGL082W		355826,	356972,	Putative protein of unknown function  predicted prenylation/proteolysis target of Afc1p and Rce1p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YGL082W is not an essential gene
chrVII	357376	358339	357376	358339	+	YGL081W	YGL081W		357376,	358339,	Putative protein of unknown function  non-essential gene  interacts genetically with CHS5, a gene involved in chitin biosynthesis
chrVII	358635	359028	358635	359028	+	FMP37	YGL080W		358635,	359028,	Putative protein of unknown function  highly conserved across species and orthologous to human gene BRP44L  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	359443	360100	359443	360100	+	KXD1	YGL079W		359443,	360100,	Putative protein of unknown function  likely member of BLOC complex involved in endosomal cargo sorting  null mutant is sensitive to drug inducing secretion of vacuolar cargo  GFP-fusion protein localizes to the endosome
chrVII	360287	361859	360287	361859	-	DBP3	YGL078C		360287,	361859,	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
chrVII	362224	363916	362224	363916	-	HNM1	YGL077C		362224,	363916,	Choline/ethanolamine transporter  involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress  co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
chrVII	364334	365996	364334	365996	-	RPL7A	YGL076C		364334,365432,365985,	364964,365526,365996,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins  contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
chrVII	366924	368088	366924	368088	-	MPS2	YGL075C		366924,	368088,	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope  potentially phosphorylated by Cdc28p
chrVII	368595	368922	368595	368922	-	YGL074C	YGL074C		368595,	368922,	Dubious open reading frame unlikely to encode a functional protein  overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
chrVII	368752	371254	368752	371254	+	HSF1	YGL073W		368752,	371254,	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia  recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats  posttranslationally regulated
chrVII	371002	371362	371002	371362	-	YGL072C	YGL072C		371002,	371362,	Dubious open reading frame unlikely to encode a protein  partially overlaps the verified gene HSF1  null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
chrVII	372011	374084	372011	374084	+	AFT1	YGL071W		372011,	374084,	Transcription factor involved in iron utilization and homeostasis  binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
chrVII	374458	374827	374458	374827	-	RPB9	YGL070C		374458,	374827,	RNA polymerase II subunit B12.6  contacts DNA  mutations affect transcription start site selection and fidelity of transcription
chrVII	375049	375514	375049	375514	-	YGL069C	YGL069C		375049,	375514,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  92% of ORF overlaps the uncharacterized ORF YGL068W  deletion in cyr1 mutant results in loss of stress resistance
chrVII	375086	375671	375086	375671	+	MNP1	YGL068W		375086,	375671,	Protein associated with the mitochondrial nucleoid  putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein  required for normal respiratory growth
chrVII	376100	377255	376100	377255	+	NPY1	YGL067W		376100,	377255,	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides  localizes to peroxisomes
chrVII	377608	379582	377608	379582	+	SGF73	YGL066W		377608,	379582,	SAGA complex subunit  has a role in anchoring the deubiquitination module into SAGA and SLIK complexes  involved in preinitiation complex assembly at promoters  human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases  mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
chrVII	379759	381271	379759	381271	-	ALG2	YGL065C		379759,	381271,	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway  alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
chrVII	381522	383208	381522	383208	-	MRH4	YGL064C		381522,	383208,	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
chrVII	383653	384766	383653	384766	+	PUS2	YGL063W		383653,	384766,	Mitochondrial tRNA:pseudouridine synthase  acts at positions 27 and 28, but not at position 72  efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
chrVII	384501	384651	384501	384651	-	YGL063C-A	YGL063C-A		384501,	384651,	Dubious open reading frame unlikely to encode a functional protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVII	385195	388732	385195	388732	+	PYC1	YGL062W		385195,	388732,	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate  highly similar to isoform Pyc2p but differentially regulated  mutations in the human homolog are associated with lactic acidosis
chrVII	388967	389711	388967	389711	-	DUO1	YGL061C		388967,	389711,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  is transferred to the kinetochore prior to mitosis
chrVII	390064	391990	390064	391990	+	YBP2	YGL060W		390064,	391990,	Central kinetochore associated protein that mediates mitotic progression  interacts with several central kinetochore proteins and the centromeric histone Cse4p  role in resistance to oxidative stress  similarity to Ybp1p and Slk19p
chrVII	392222	393698	392222	393698	+	PKP2	YGL059W		392222,	393698,	Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit  acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p
chrVII	393985	394504	393985	394504	+	RAD6	YGL058W		393985,	394504,	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
chrVII	394965	395829	394965	395829	-	GEP7	YGL057C		394965,	395829,	Protein of unknown function  null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1  authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	396034	397618	396034	397618	-	SDS23	YGL056C		396034,	397618,	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation  involved in cell separation during budding
chrVII	398627	400160	398627	400160	+	OLE1	YGL055W		398627,	400160,	Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
chrVII	400870	401287	400870	401287	-	ERV14	YGL054C		400870,	401287,	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo  required for the delivery of bud-site selection protein Axl2p to cell surface  related to Drosophila cornichon
chrVII	402588	403302	402588	403302	+	PRM8	YGL053W		402588,	403302,	Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding  forms a complex with Prp9p in the ER  member of DUP240 gene family
chrVII	403436	403742	403436	403742	+	YGL052W	YGL052W		403436,	403742,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF MST27
chrVII	403686	404391	403686	404391	+	MST27	YGL051W		403686,	404391,	Putative integral membrane protein, involved in vesicle formation  forms complex with Mst28p  member of DUP240 gene family  binds COPI and COPII vesicles
chrVII	405775	406597	405775	406597	+	TYW3	YGL050W		405775,	406597,	tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
chrVII	406859	409604	406859	409604	-	TIF4632	YGL049C		406859,	409604,	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p)  associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p)  homologous to Tif4631p
chrVII	410068	411286	410068	411286	-	RPT6	YGL048C		410068,	411286,	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates  bound by ubiquitin-protein ligases Ubr1p and Ufd4p  localized mainly to the nucleus throughout the cell cycle
chrVII	411551	412160	411551	412160	+	ALG13	YGL047W		411551,	412160,	Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis  anchored to the ER membrane via interaction with Alg14p  similar to bacterial and human glycosyltransferases
chrVII	414101	415730	414101	415730	+	RIM8	YGL045W		414101,	415730,	Protein involved in proteolytic activation of Rim101p in response to alkaline pH  interacts with ESCRT-1 subunits Stp22p and Vps28p  essential for anaerobic growth  member of the arrestin-related trafficking adaptor family
chrVII	416145	417036	416145	417036	-	RNA15	YGL044C		416145,	417036,	Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends  interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p  mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
chrVII	417482	418412	417482	418412	+	DST1	YGL043W		417482,	418412,	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
chrVII	418287	418593	418287	418593	-	YGL042C	YGL042C		418287,	418593,	Dubious open reading frame, not conserved in closely related Saccharomyces species  deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
chrVII	418703	418886	418703	418886	-	YGL041C-B	YGL041C-B		418703,	418886,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrVII	418824	419289	418824	419289	+	YGL041W-A	YGL041W-A		418824,	419289,	Putative protein of unknown function, conserved in fungi  identified by expression profiling and mass spectrometry
chrVII	419021	419225	419021	419225	-	YGL041C	YGL041C		419021,	419225,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	419526	420555	419526	420555	-	HEM2	YGL040C		419526,	420555,	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis  enzymatic activity is zinc-dependent  localizes to the cytoplasm and nucleus
chrVII	423960	425007	423960	425007	+	YGL039W	YGL039W		423960,	425007,	Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
chrVII	425361	426804	425361	426804	-	OCH1	YGL038C		425361,	426804,	Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
chrVII	427296	427947	427296	427947	-	PNC1	YGL037C		427296,	427947,	Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction  PNC1 expression responds to all known stimuli that extend replicative life span
chrVII	428600	431330	428600	431330	+	YGL036W	YGL036W		428600,	431330,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YGL036W is not an essential gene
chrVII	431547	433062	431547	433062	-	MIG1	YGL035C		431547,	433062,	Transcription factor involved in glucose repression  sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs  regulated by the SNF1 kinase and the GLC7 phosphatase
chrVII	433213	433579	433213	433579	-	YGL034C	YGL034C		433213,	433579,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	435624	436351	435624	436351	+	HOP2	YGL033W		435624,435749,	435679,436351,	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs  complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
chrVII	436569	436833	436569	436833	-	AGA2	YGL032C		436569,	436833,	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
chrVII	437466	437934	437466	437934	-	RPL24A	YGL031C		437466,	437934,	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein  not essential for translation but may be required for normal translation rate
chrVII	439090	439638	439090	439638	+	RPL30	YGL030W		439090,439323,	439093,439638,	Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein  involved in pre-rRNA processing in the nucleolus  autoregulates splicing of its transcript
chrVII	440062	440425	440062	440425	+	CGR1	YGL029W		440062,	440425,	Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit  transcript is induced in response to cytotoxic stress but not genotoxic stress
chrVII	441280	442909	441280	442909	-	SCW11	YGL028C		441280,	442909,	Cell wall protein with similarity to glucanases  may play a role in conjugation during mating based on its regulation by Ste12p
chrVII	443641	446143	443641	446143	-	CWH41	YGL027C		443641,	446143,	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation  also involved in ER protein quality control and sensing of ER stress
chrVII	446411	448535	446411	448535	-	TRP5	YGL026C		446411,	448535,	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis  regulated by the general control system of amino acid biosynthesis
chrVII	448763	449957	448763	449957	-	PGD1	YGL025C		448763,	449957,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for basal and activated transcription  direct target of Cyc8p-Tup1p transcriptional corepressor
chrVII	449787	450123	449787	450123	+	YGL024W	YGL024W		449787,	450123,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially/completely overlaps the verified ORF PGD1/YGL025C
chrVII	450196	452104	450196	452104	-	PIB2	YGL023C		450196,	452104,	Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression  similar to Fab1 and Vps27
chrVII	452403	454560	452403	454560	+	STT3	YGL022W		452403,	454560,	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins  forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
chrVII	454784	457067	454784	457067	+	ALK1	YGL021W		454784,	457067,	Protein kinase  accumulation and phosphorylation are periodic during the cell cycle  phosphorylated in response to DNA damage  contains characteristic motifs for degradation via the APC pathway  similar to Alk2p and to mammalian haspins
chrVII	457162	457870	457162	457870	-	GET1	YGL020C		457162,	457870,	Subunit of the GET complex  involved in insertion of proteins into the ER membrane  required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
chrVII	458155	458992	458155	458992	+	CKB1	YGL019W		458155,	458992,	Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation  CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
chrVII	459109	459664	459109	459664	-	JAC1	YGL018C		459109,	459664,	Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism  contains a J domain typical to J-type chaperones  localizes to the mitochondrial matrix
chrVII	459853	461365	459853	461365	+	ATE1	YGL017W		459853,	461365,	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
chrVII	461665	464911	461665	464911	+	KAP122	YGL016W		461665,	464911,	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus  binds to nucleoporins Nup1p and Nup2p  may play a role in regulation of pleiotropic drug resistance
chrVII	465042	465435	465042	465435	-	YGL015C	YGL015C		465042,	465435,	Putative protein of unknown function  null mutants accumulate cargo in the Golgi
chrVII	466140	468807	466140	468807	+	PUF4	YGL014W		466140,	468807,	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity  preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
chrVII	466236	466398	466236	466398	-	YGL014C-A	YGL014C-A		466236,	466398,	Dubious open reading frame, unlikely to encode a functional protein  identified by expression profiling and mass spectrometry
chrVII	469091	472298	469091	472298	-	PDR1	YGL013C		469091,	472298,	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
chrVII	472854	474276	472854	474276	+	ERG4	YGL012W		472854,	474276,	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis  mutants are viable, but lack ergosterol
chrVII	474488	475247	474488	475247	-	SCL1	YGL011C		474488,	475247,	Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates  20S proteasome is the core complex of the 26S proteasome  essential for growth  detected in the mitochondria
chrVII	475544	476069	475544	476069	+	YGL010W	YGL010W		475544,	476069,	Putative protein of unknown function  YGL010W is not an essential gene
chrVII	476312	478652	476312	478652	-	LEU1	YGL009C		476312,	478652,	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
chrVII	479909	482666	479909	482666	-	PMA1	YGL008C		479909,	482666,	Plasma membrane H+-ATPase, pumps protons out of the cell  major regulator of cytoplasmic pH and plasma membrane potential  P2-type ATPase  Hsp30p plays a role in Pma1p regulation  interactions with Std1p appear to propagate [GAR+]
chrVII	482940	483027	482940	483027	-	YGL007C-A	YGL007C-A		482940,	483027,	Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching  deletion exhibits slow-growth phenotype  computationally predicted to have a role in cell budding
chrVII	483259	483637	483259	483637	+	BRP1	YGL007W		483259,	483637,	Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
chrVII	485422	485533	485422	485533	+	YGL006W-A	YGL006W-A		485422,	485533,	Putative protein of unknown function  identified by SAGE
chrVII	485920	489442	485920	489442	+	PMC1	YGL006W		485920,	489442,	Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions  prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium  similar to mammalian PMCA1a
chrVII	489707	490547	489707	490547	-	COG7	YGL005C		489707,	490547,	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrVII	490702	491956	490702	491956	-	RPN14	YGL004C		490702,	491956,	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP)  null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability  interacts with Rpt5p
chrVII	492473	494174	492473	494174	-	CDH1	YGL003C		492473,	494174,	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit  targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
chrVII	494516	495167	494516	495167	+	ERP6	YGL002W		494516,	495167,	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	495452	496502	495452	496502	-	ERG26	YGL001C		495452,	496502,	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
chrVII	497132	498034	497132	498034	-	YGR001C	YGR001C		497132,497458,497999,	497365,497937,498034,	Putative protein of unknown function with similarity to methyltransferase family members  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  required for replication of Brome mosaic virus in S. cerevisiae
chrVII	498475	499906	498475	499906	-	SWC4	YGR002C		498475,	499906,	Component of the Swr1p complex that incorporates Htz1p into chromatin  component of the NuA4 histone acetyltransferase complex
chrVII	500131	502366	500131	502366	+	CUL3	YGR003W		500131,	502366,	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis  cullin family member with similarity to Cdc53p and human CUL3
chrVII	502937	504326	502937	504326	+	PEX31	YGR004W		502937,	504326,	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size  partially functionally redundant with Pex30p and Pex32p  probably acts at a step downstream of steps mediated by Pex28p and Pex29p
chrVII	504656	505859	504656	505859	-	TFG2	YGR005C		504656,	505859,	TFIIF (Transcription Factor II) middle subunit  involved in both transcription initiation and elongation of RNA polymerase II  homologous to human RAP30
chrVII	506069	506825	506069	506825	+	PRP18	YGR006W		506069,	506825,	Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p
chrVII	506968	507940	506968	507940	+	ECT1	YGR007W		506968,	507940,	Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis  involved in the maintenance of plasma membrane  similar to mammalian CTP: phosphocholine cytidylyl-transferases
chrVII	508109	508364	508109	508364	-	STF2	YGR008C		508109,	508364,	Protein involved in regulation of the mitochondrial F1F0-ATP synthase  Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
chrVII	509046	511002	509046	511002	-	SEC9	YGR009C		509046,	511002,	t-SNARE protein important for fusion of secretory vesicles with the plasma membrane  similar to but not functionally redundant with Spo20p  SNAP-25 homolog
chrVII	511544	512732	511544	512732	+	NMA2	YGR010W		511544,	512732,	Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+)
chrVII	512496	512823	512496	512823	+	YGR011W	YGR011W		512496,	512823,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	513158	514340	513158	514340	+	YGR012W	YGR012W		513158,	514340,	Putative cysteine synthase, localized to the mitochondrial outer membrane
chrVII	514553	516416	514553	516416	+	SNU71	YGR013W		514553,	516416,	Component of U1 snRNP required for mRNA splicing via spliceosome  yeast specific, no metazoan counterpart
chrVII	516942	520863	516942	520863	+	MSB2	YGR014W		516942,	520863,	Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway  also functions as an osmosensor in parallel to the Sho1p-mediated pathway  potential Cdc28p substrate
chrVII	521089	522076	521089	522076	-	YGR015C	YGR015C		521089,	522076,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
chrVII	522260	522833	522260	522833	+	YGR016W	YGR016W		522260,	522833,	Putative protein of unknown function
chrVII	523786	524680	523786	524680	+	YGR017W	YGR017W		523786,	524680,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
chrVII	524364	524694	524364	524694	-	YGR018C	YGR018C		524364,	524694,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YGR017W
chrVII	525228	526644	525228	526644	+	UGA1	YGR019W		525228,	526644,	Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways  required for normal oxidative stress tolerance and nitrogen utilization
chrVII	526972	527329	526972	527329	-	VMA7	YGR020C		526972,	527329,	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system  required for the V1 domain to assemble onto the vacuolar membrane
chrVII	527631	528504	527631	528504	+	YGR021W	YGR021W		527631,	528504,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	529256	529586	529256	529586	-	YGR022C	YGR022C		529256,	529586,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps almost completely with the verified ORF MTL1/YGR023W
chrVII	529263	530919	529263	530919	+	MTL1	YGR023W		529263,	530919,	Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress  has structural and functional similarity to Mid2p
chrVII	531882	532596	531882	532596	-	THG1	YGR024C		531882,	532596,	tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage  couples nuclear division and migration to cell budding and cytokinesis  essential enzyme conserved among eukaryotes
chrVII	532638	532941	532638	532941	+	YGR025W	YGR025W		532638,	532941,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	532984	533821	532984	533821	+	YGR026W	YGR026W		532984,	533821,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
chrVII	534131	534458	534131	534458	-	RPS25A	YGR027C		534131,	534458,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
chrVII	536056	541325	536056	541325	+	YGR027W-B	YGR027W-B		536056,537362,	537361,541325,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVII	536056	537379	536056	537379	+	YGR027W-A	YGR027W-A		536056,	537379,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVII	542202	543291	542202	543291	+	MSP1	YGR028W		542202,	543291,	Mitochondrial protein involved in sorting of proteins in the mitochondria  putative membrane-spanning ATPase
chrVII	543552	544205	543552	544205	+	ERV1	YGR029W		543552,543721,	543638,544205,	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins  ortholog of human hepatopoietin (ALR)
chrVII	545680	546157	545680	546157	-	POP6	YGR030C		545680,	546157,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
chrVII	546440	547469	546440	547469	+	YGR031W	YGR031W		546440,	547469,	Conserved mitochondrial protein of unknown function  processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase  gene contains the nested antisense gene NAG1
chrVII	546808	547300	546808	547300	-	NAG1	YGR031C-A		546808,	547300,	Protein involved in yeast cell wall biogenesis  localizes to the cell periphery  production of Nag1p is dependent upon the presence of Slt2p and Rlm1p  gene is nested within and antisense to IMO32
chrVII	548263	553951	548263	553951	+	GSC2	YGR032W		548263,	553951,	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall  activity positively regulated by Rho1p and negatively by Smk1p  has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
chrVII	554247	554967	554247	554967	-	TIM21	YGR033C		554247,	554967,	Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes  may regulate TIM23 complex activity
chrVII	555811	556672	555811	556672	+	RPL26B	YGR034W		555811,556307,	555830,556672,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins  binds to 5.8S rRNA
chrVII	557071	557422	557071	557422	-	YGR035C	YGR035C		557071,	557422,	Putative protein of unknown function, potential Cdc28p substrate  transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
chrVII	557564	557786	557564	557786	+	YGR035W-A	YGR035W-A		557564,	557786,	Putative protein of unknown function
chrVII	558148	558868	558148	558868	-	CAX4	YGR036C		558148,	558868,	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
chrVII	559730	559994	559730	559994	-	ACB1	YGR037C		559730,	559994,	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes  subject to starvation-induced, Grh1p-mediated unconventional secretion
chrVII	560681	561350	560681	561350	+	ORM1	YGR038W		560681,	561350,	Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response  Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
chrVII	562198	567467	562198	567467	-	YGR038C-B	YGR038C-B		562198,566162,	566161,567467,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVII	566144	567467	566144	567467	-	YGR038C-A	YGR038C-A		566144,	567467,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVII	574887	575199	574887	575199	+	YGR039W	YGR039W		574887,	575199,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the Autonomously Replicating Sequence ARS722
chrVII	575397	576504	575397	576504	+	KSS1	YGR040W		575397,	576504,	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response  the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
chrVII	577486	579130	577486	579130	+	BUD9	YGR041W		577486,	579130,	Protein involved in bud-site selection  mutant has increased aneuploidy tolerance  diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
chrVII	579475	580291	579475	580291	+	YGR042W	YGR042W		579475,	580291,	Putative protein of unknown function  involved in maintenance of proper telomere length  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrVII	580434	581436	580434	581436	-	NQM1	YGR043C		580434,	581436,	Transaldolase of unknown function  transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
chrVII	582989	583892	582989	583892	-	RME1	YGR044C		582989,	583892,	Zinc finger protein involved in control of meiosis  prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression  directly repressed by a1-alpha2 regulator  mediates cell type control of sporulation
chrVII	583933	584296	583933	584296	-	YGR045C	YGR045C		583933,	584296,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrVII	584894	586052	584894	586052	+	TAM41	YGR046W		584894,	586052,	Mitochondrial protein involved in protein import into the mitochondrial matrix  maintains the functional integrity of the TIM23 protein translocator complex  viability of null mutant is strain-dependent  mRNA is targeted to the bud
chrVII	586391	589469	586391	589469	-	TFC4	YGR047C		586391,	589469,	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC)  part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes  has TPR motifs  human homolog is TFIIIC-102
chrVII	589825	590911	589825	590911	+	UFD1	YGR048W		589825,	590911,	Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation  involved in transporting proteins from the ER to the cytosol
chrVII	591313	591877	591313	591877	+	SCM4	YGR049W		591313,	591877,	Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
chrVII	592085	592442	592085	592442	-	YGR050C	YGR050C		592085,	592442,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrVII	592905	593229	592905	593229	-	YGR051C	YGR051C		592905,	593229,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YGR051C is not an essential gene
chrVII	593595	594705	593595	594705	+	FMP48	YGR052W		593595,	594705,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrVII	594985	595837	594985	595837	-	YGR053C	YGR053C		594985,	595837,	Putative protein of unknown function
chrVII	596692	598621	596692	598621	+	YGR054W	YGR054W		596692,	598621,	Eukaryotic initiation factor (eIF) 2A  associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E  homologous to mammalian eIF2A
chrVII	599416	601141	599416	601141	+	MUP1	YGR055W		599416,	601141,	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions  also involved in cysteine uptake
chrVII	601660	604447	601660	604447	+	RSC1	YGR056W		601660,	604447,	Component of the RSC chromatin remodeling complex  required for expression of mid-late sporulation-specific genes  contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
chrVII	604772	605501	604772	605501	-	LST7	YGR057C		604772,	605501,	Protein possibly involved in a post-Golgi secretory pathway  required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
chrVII	606135	607143	606135	607143	+	PEF1	YGR058W		606135,	607143,	Penta-EF-hand protein required for polar bud growth and cell wall abscission  binds calcium and zinc with different affinity  localizes to bud site in G1, bud neck in G2
chrVII	607562	609101	607562	609101	+	SPR3	YGR059W		607562,	609101,	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes  septin protein involved in sporulation  regulated by ABFI
chrVII	610563	611493	610563	611493	+	ERG25	YGR060W		610563,	611493,	C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis  mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
chrVII	611888	615965	611888	615965	-	ADE6	YGR061C		611888,	615965,	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
chrVII	616327	617278	616327	617278	-	COX18	YGR062C		616327,	617278,	Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p  interacts genetically and physically with Mss2p and Pnt1p  similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC
chrVII	617515	617824	617515	617824	-	SPT4	YGR063C		617515,	617824,	Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing  forms a complex with Spt5p
chrVII	617620	617989	617620	617989	+	YGR064W	YGR064W		617620,	617989,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF SPT4/YGR063C
chrVII	618076	619858	618076	619858	-	VHT1	YGR065C		618076,	619858,	High-affinity plasma membrane H+-biotin (vitamin H) symporter  mutation results in fatty acid auxotrophy  12 transmembrane domain containing major facilitator subfamily member  mRNA levels negatively regulated by iron deprivation and biotin
chrVII	620920	621799	620920	621799	-	YGR066C	YGR066C		620920,	621799,	Putative protein of unknown function
chrVII	622371	624786	622371	624786	-	YGR067C	YGR067C		622371,	624786,	Putative protein of unknown function  contains a zinc finger motif similar to that of Adr1p
chrVII	625323	627084	625323	627084	-	ART5	YGR068C		625323,	627084,	Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane
chrVII	626293	626389	626293	626389	+	YGR068W-A	YGR068W-A		626293,	626389,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps with the uncharacterized ORF YGR068C
chrVII	627082	627418	627082	627418	+	YGR069W	YGR069W		627082,	627418,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrVII	627805	631273	627805	631273	+	ROM1	YGR070W		627805,	631273,	GDP/GTP exchange protein (GEP) for Rho1p  mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
chrVII	631480	634063	631480	634063	-	YGR071C	YGR071C		631480,	634063,	Putative protein of unknown function  deletion mutant has increased glycogen accumulation and displays elongated buds  green fluorescent protein (GFP)-fusion protein localizes to the nucleus
chrVII	634303	635467	634303	635467	+	UPF3	YGR072W		634303,	635467,	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p  involved in decay of mRNA containing nonsense codons  involved in telomere maintenance
chrVII	635614	635986	635614	635986	-	YGR073C	YGR073C		635614,	635986,	Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
chrVII	635711	636152	635711	636152	+	SMD1	YGR074W		635711,	636152,	Core Sm protein Sm D1  part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs  homolog of human Sm D1
chrVII	636146	636875	636146	636875	-	PRP38	YGR075C		636146,	636875,	Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome  dispensible for spliceosome assembly
chrVII	637103	637577	637103	637577	-	MRPL25	YGR076C		637103,	637577,	Mitochondrial ribosomal protein of the large subunit
chrVII	637743	639513	637743	639513	-	PEX8	YGR077C		637743,	639513,	Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p
chrVII	639771	640371	639771	640371	-	PAC10	YGR078C		639771,	640371,	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
chrVII	640719	641832	640719	641832	+	YGR079W	YGR079W		640719,	641832,	Putative protein of unknown function  YGR079W is not an essential gene
chrVII	642009	643008	642009	643008	+	TWF1	YGR080W		642009,	643008,	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
chrVII	643147	643780	643147	643780	-	SLX9	YGR081C		643147,	643780,	Protein required for pre-rRNA processing  associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor  interacts with U3 snoRNA  deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
chrVII	644043	644595	644043	644595	+	TOM20	YGR082W		644043,	644595,	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins  acts as a receptor for incoming precursor proteins
chrVII	644859	646815	644859	646815	-	GCD2	YGR083C		644859,	646815,	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2  activity subsequently regulated by phosphorylated eIF2  first identified as a negative regulator of GCN4 expression
chrVII	647122	648142	647122	648142	-	MRP13	YGR084C		647122,	648142,	Mitochondrial ribosomal protein of the small subunit
chrVII	648382	648907	648382	648907	-	RPL11B	YGR085C		648382,	648907,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap  involved in ribosomal assembly  depletion causes degradation of proteins and RNA of the 60S subunit  has similarity to E. coli L5 and rat L11
chrVII	649597	650617	649597	650617	-	PIL1	YGR086C		649597,	650617,	Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis  null mutants show activation of Pkc1p/Ypk1p stress resistance pathways  detected in phosphorylated state in mitochondria  member of the BAR domain family
chrVII	651289	652981	651289	652981	-	PDC6	YGR087C		651289,	652981,	Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism  transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
chrVII	654633	656322	654633	656322	+	CTT1	YGR088W		654633,	656322,	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
chrVII	656959	659770	656959	659770	+	NNF2	YGR089W		656959,	659770,	Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III  computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
chrVII	662357	666071	662357	666071	+	UTP22	YGR090W		662357,	666071,	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
chrVII	666340	667825	666340	667825	+	PRP31	YGR091W		666340,	667825,	Splicing factor, component of the U4/U6-U5 snRNP complex
chrVII	668188	669907	668188	669907	+	DBF2	YGR092W		668188,	669907,	Ser/Thr kinase involved in transcription and stress response  functions as part of a network of genes in exit from mitosis  localization is cell cycle regulated  activated by Cdc15p during the exit from mitosis
chrVII	670387	671911	670387	671911	+	YGR093W	YGR093W		670387,	671911,	Putative protein of unconfirmed function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus
chrVII	672185	675500	672185	675500	+	VAS1	YGR094W		672185,	675500,	Mitochondrial and cytoplasmic valyl-tRNA synthetase
chrVII	675670	676342	675670	676342	-	RRP46	YGR095C		675670,	676342,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
chrVII	676620	677565	676620	677565	+	TPC1	YGR096W		676620,	677565,	Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria  expression appears to be regulated by carbon source  member of the mitochondrial carrier family
chrVII	678694	682135	678694	682135	+	ASK10	YGR097W		678694,	682135,	Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress  has a role in destruction of Ssn8p  proposed to function in activation of the glycerol channel Fps1p  paralogous to Rgc1p
chrVII	682565	687458	682565	687458	-	ESP1	YGR098C		682565,	687458,	Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin  inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit  inhibited by Pds1p
chrVII	687898	689965	687898	689965	+	TEL2	YGR099W		687898,	689965,	Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect
chrVII	690244	693097	690244	693097	+	MDR1	YGR100W		690244,	693097,	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p  involved in recycling of internalized proteins and regulation of Golgi secretory function
chrVII	693362	694403	693362	694403	+	PCP1	YGR101W		693362,	694403,	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology  belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
chrVII	694583	695135	694583	695135	-	YGR102C	YGR102C		694583,	695135,	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex  involved in the formation of Q-tRNAQ  transposon insertion mutant is salt sensitive and null mutant has growth defects  non-tagged protein is detected in purified mitochondria
chrVII	695416	697234	695416	697234	+	NOP7	YGR103W		695416,	697234,	Component of several different pre-ribosomal particles  forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit  required for exit from G0 and the initiation of cell proliferation
chrVII	697444	698368	697444	698368	-	SRB5	YGR104C		697444,	698368,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation  involved in telomere maintenance
chrVII	698598	698832	698598	698832	+	VMA21	YGR105W		698598,	698832,	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex  functions in the assembly of the V-ATPase  localized to the yeast endoplasmic reticulum (ER)
chrVII	698988	699786	698988	699786	-	VOA1	YGR106C		698988,	699786,	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase)  null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
chrVII	702666	703116	702666	703116	+	YGR107W	YGR107W		702666,	703116,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrVII	703635	705051	703635	705051	+	CLB1	YGR108W		703635,	705051,	B-type cyclin involved in cell cycle progression  activates Cdc28p to promote the transition from G2 to M phase  accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
chrVII	705358	706501	705358	706501	-	CLB6	YGR109C		705358,	706501,	B-type cyclin involved in DNA replication during S phase  activates Cdc28p to promote initiation of DNA synthesis  functions in formation of mitotic spindles along with Clb3p and Clb4p  most abundant during late G1
chrVII	707609	712254	707609	712254	+	YGR109W-B	YGR109W-B		707609,708460,	708459,712254,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVII	707609	708482	707609	708482	+	YGR109W-A	YGR109W-A		707609,	708482,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVII	713708	715046	713708	715046	+	CLD1	YGR110W		713708,	715046,	Mitochondrial cardiolipin-specific phospholipase  functions upstream of Taz1p to generate monolyso-cardiolipin  transcription increases upon genotoxic stress  involved in restricting Ty1 transposition  has homology to mammalian CGI-58
chrVII	715827	717030	715827	717030	+	YGR111W	YGR111W		715827,	717030,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrVII	717357	718527	717357	718527	+	SHY1	YGR112W		717357,	718527,	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV)  associates with complex IV assembly intermediates and complex III/complex IV supercomplexes  similar to human SURF1 involved in Leigh Syndrome
chrVII	718892	719924	718892	719924	+	DAM1	YGR113W		718892,	719924,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  Ipl1p target for regulating kinetochore-MT attachments
chrVII	720264	720654	720264	720654	-	YGR114C	YGR114C		720264,	720654,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  open reading frame overlaps 5' end of the essential gene SPT6
chrVII	720371	721151	720371	721151	-	YGR115C	YGR115C		720371,	721151,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified and essential ORF SPT6/YGR115C
chrVII	720408	724764	720408	724764	+	SPT6	YGR116W		720408,	724764,	Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
chrVII	725048	726479	725048	726479	-	YGR117C	YGR117C		725048,	726479,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrVII	726973	727730	726973	727730	+	RPS23A	YGR118W		726973,727357,	727038,727730,	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy  nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins  deletion of both RPS23A and RPS23B is lethal
chrVII	728045	729671	728045	729671	-	NUP57	YGR119C		728045,	729671,	Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p
chrVII	730032	730821	730032	730821	-	COG2	YGR120C		730032,	730821,	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrVII	731448	732927	731448	732927	-	MEP1	YGR121C		731448,	732927,	Ammonium permease  belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+)  expression is under the nitrogen catabolite repression regulation
chrVII	733411	733627	733411	733627	+	YGR121W-A	YGR121W-A		733411,	733627,	Putative protein of unknown function
chrVII	733934	735143	733934	735143	+	YGR122W	YGR122W		733934,	735143,	Probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex  null mutant does not properly process Rim101p and has decreased resistance to rapamycin  GFP-fusion protein is cytoplasmic
chrVII	735629	735758	735629	735758	-	YGR122C-A	YGR122C-A		735629,	735758,	Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
chrVII	736661	738203	736661	738203	-	PPT1	YGR123C		736661,	738203,	Protein serine/threonine phosphatase with similarity to human phosphatase PP5  present in both the nucleus and cytoplasm  expressed during logarithmic growth  computational analyses suggest roles in phosphate metabolism and rRNA processing
chrVII	739943	741662	739943	741662	+	ASN2	YGR124W		739943,	741662,	Asparagine synthetase, isozyme of Asn1p  catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
chrVII	742324	745435	742324	745435	+	YGR125W	YGR125W		742324,	745435,	Putative protein of unknown function  deletion mutant has decreased rapamycin resistance but normal wormannin resistance  green fluorescent protein (GFP)-fusion protein localizes to the vacuole
chrVII	745834	746527	745834	746527	+	YGR126W	YGR126W		745834,	746527,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
chrVII	746797	747736	746797	747736	+	YGR127W	YGR127W		746797,	747736,	Putative protein of unknown function  expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
chrVII	747949	750091	747949	750091	-	UTP8	YGR128C		747949,	750091,	Nucleolar protein required for export of tRNAs from the nucleus  also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
chrVII	750399	751047	750399	751047	+	SYF2	YGR129W		750399,	751047,	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs  isy1 syf2 cells have defective spindles activiating cell cycle arrest
chrVII	751393	753844	751393	753844	-	YGR130C	YGR130C		751393,	753844,	Component of the eisosome with unknown function  GFP-fusion protein localizes to the cytoplasm  specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
chrVII	754725	755250	754725	755250	+	FHN1	YGR131W		754725,	755250,	Protein of unknown function  induced by ketoconazole  promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site  overexpression complements function of Nce102p in NCE102 deletion strain
chrVII	755588	756452	755588	756452	-	PHB1	YGR132C		755588,	756452,	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins  determinant of replicative life span  involved in mitochondrial segregation
chrVII	756895	757447	756895	757447	+	PEX4	YGR133W		756895,	757447,	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
chrVII	757769	761138	757769	761138	+	CAF130	YGR134W		757769,	761138,	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
chrVII	761391	762168	761391	762168	+	PRE9	YGR135W		761391,	762168,	Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit  may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
chrVII	762427	763153	762427	763153	+	LSB1	YGR136W		762427,	763153,	Protein containing an N-terminal SH3 domain  binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
chrVII	762887	763262	762887	763262	+	YGR137W	YGR137W		762887,	763262,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	763761	765606	763761	765606	-	TPO2	YGR138C		763761,	765606,	Polyamine transport protein specific for spermine  localizes to the plasma membrane  transcription of TPO2 is regulated by Haa1p  member of the major facilitator superfamily
chrVII	765725	766064	765725	766064	+	YGR139W	YGR139W		765725,	766064,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	767428	770299	767428	770299	+	CBF2	YGR140W		767428,	770299,	Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere  Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
chrVII	770568	771972	770568	771972	+	VPS62	YGR141W		770568,	771972,	Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
chrVII	772453	773686	772453	773686	+	BTN2	YGR142W		772453,	773686,	v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi  modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
chrVII	775192	777508	775192	777508	+	SKN1	YGR143W		775192,	777508,	Protein involved in sphingolipid biosynthesis  type II membrane protein with similarity to Kre6p
chrVII	780398	781379	780398	781379	+	THI4	YGR144W		780398,	781379,	Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis  required for mitochondrial genome stability in response to DNA damaging agents
chrVII	781766	783890	781766	783890	+	ENP2	YGR145W		781766,	783890,	Essential nucleolar protein, required for biogenesis of the small ribosomal subunit  contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
chrVII	784222	784858	784222	784858	-	ECL1	YGR146C		784222,	784858,	Protein of unknown function, affects chronological lifespan  induced by iron homeostasis transcription factor Aft2p  multicopy suppressor of temperature sensitive hsf1 mutant  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrVII	785275	785437	785275	785437	-	YGR146C-A	YGR146C-A		785275,	785437,	Putative protein of unknown function
chrVII	786053	786920	786053	786920	-	NAT2	YGR147C		786053,	786920,	Protein with an apparent role in acetylation of N-terminal methionine residues
chrVII	787311	787779	787311	787779	-	RPL24B	YGR148C		787311,	787779,	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein  not essential for translation but may be required for normal translation rate
chrVII	789030	790329	789030	790329	+	YGR149W	YGR149W		789030,	790329,	Putative protein of unknown function  predicted to be an integal membrane protein
chrVII	790458	793053	790458	793053	-	CCM1	YGR150C		790458,	793053,	Mitochondrial 15s rRNA-binding protein  required for intron removal of COB and COX1 pre-mRNAs  contains pentatricopeptide repeat (PPR) motifs  mutant is respiratory deficient and has defective plasma membrane electron transport
chrVII	794654	794990	794654	794990	-	YGR151C	YGR151C		794654,	794990,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
chrVII	794673	795492	794673	795492	-	RSR1	YGR152C		794673,	795492,	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion  localized to the plasma membrane  significantly similar to mammalian Rap GTPases
chrVII	796091	796745	796091	796745	+	YGR153W	YGR153W		796091,	796745,	Putative protein of unknown function
chrVII	796797	797868	796797	797868	-	GTO1	YGR154C		796797,	797868,	Omega-class glutathione transferase  induced under oxidative stress  putative peroxisomal localization
chrVII	798542	800066	798542	800066	+	CYS4	YGR155W		798542,	800066,	Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis  responsible for hydrogen sulfide generation  mutations in human ortholog cause homocystinuria
chrVII	800545	801823	800545	801823	+	PTI1	YGR156W		800545,	801823,	Essential protein that is a component of CPF (cleavage and polyadenylation factor)  involved in 3' end formation of snoRNA and mRNA  interacts directly with Pta1p  has similarity to mammalian Cleavage-Stimulation Factor CstF-64
chrVII	802439	805049	802439	805049	+	CHO2	YGR157W		802439,	805049,	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
chrVII	805268	806021	805268	806021	-	MTR3	YGR158C		805268,	806021,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
chrVII	806411	807656	806411	807656	-	NSR1	YGR159C		806411,	807656,	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
chrVII	807072	807684	807072	807684	+	YGR160W	YGR160W		807072,	807684,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	808628	809420	808628	809420	-	RTS3	YGR161C		808628,	809420,	Putative component of the protein phosphatase type 2A complex
chrVII	810226	810505	810226	810505	+	YGR161W-C	YGR161W-C		810226,	810505,	Putative protein of unknown function  identified by sequence comparison with hemiascomycetous yeast species
chrVII	811737	817051	811737	817051	+	YGR161W-B	YGR161W-B		811737,813031,	813030,817051,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVII	811737	813054	811737	813054	+	YGR161W-A	YGR161W-A		811737,	813054,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVII	817746	823015	817746	823015	-	YGR161C-D	YGR161C-D		817746,821710,	821709,823015,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVII	821692	823015	821692	823015	-	YGR161C-C	YGR161C-C		821692,	823015,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVII	824058	826917	824058	826917	+	TIF4631	YGR162W		824058,	826917,	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p)  interacts with Pab1p and with eIF4A (Tif1p)  also has a role in biogenesis of the large ribosomal subunit
chrVII	827551	828577	827551	828577	+	GTR2	YGR163W		827551,	828577,	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle  activates transcription  subunit of EGO and GSE complexes  required for sorting of Gap1p  localizes to cytoplasm and to chromatin  homolog of human RagC and RagD
chrVII	828624	828960	828624	828960	+	YGR164W	YGR164W		828624,	828960,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	829115	830153	829115	830153	+	MRPS35	YGR165W		829115,	830153,	Mitochondrial ribosomal protein of the small subunit  null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
chrVII	830514	832197	830514	832197	+	KRE11	YGR166W		830514,	832197,	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p  involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi  role in cell wall beta-glucan biosynthesis and the stress response
chrVII	832455	833157	832455	833157	+	CLC1	YGR167W		832455,	833157,	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis  thought to regulate clathrin function  two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
chrVII	833351	834482	833351	834482	-	YGR168C	YGR168C		833351,	834482,	Putative protein of unknown function  YGR168C is not an essential gene
chrVII	834688	835903	834688	835903	-	PUS6	YGR169C		834688,	835903,	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs  mutation of Asp168 to Ala abolishes enzyme activity  not essential for viability
chrVII	836386	836665	836386	836665	-	YGR169C-A	YGR169C-A		836386,	836665,	Putative protein of unknown function
chrVII	837141	840558	837141	840558	+	PSD2	YGR170W		837141,	840558,	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
chrVII	840823	842551	840823	842551	-	MSM1	YGR171C		840823,	842551,	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis  functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
chrVII	842844	843591	842844	843591	-	YIP1	YGR172C		842844,	843591,	Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles  interacts with Yif1p and Yos1p  localizes to the Golgi, the ER, and COPII vesicles  homolog of human YIPF4
chrVII	843853	844960	843853	844960	+	RBG2	YGR173W		843853,	844960,	Protein with a role in translation  forms a complex with Gir2p  has similarity to mammalian developmentally regulated GTP-binding protein
chrVII	845892	846405	845892	846405	-	CBP4	YGR174C		845892,	846405,	Mitochondrial protein required for assembly of cytochrome bc1 complex  interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
chrVII	846654	846741	846654	846741	+	YGR174W-A	YGR174W-A		846654,	846741,	Putative protein of unknown function  predicted to have a role in cell budding based on computational "guilt by association" analysis
chrVII	846932	848423	846932	848423	-	ERG1	YGR175C		846932,	848423,	Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene  plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
chrVII	848719	849067	848719	849067	+	YGR176W	YGR176W		848719,	849067,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVII	848828	850436	848828	850436	-	ATF2	YGR177C		848828,	850436,	Alcohol acetyltransferase, may play a role in steroid detoxification  forms volatile esters during fermentation, which is important for brewing and winemaking
chrVII	851046	853215	851046	853215	-	PBP1	YGR178C		851046,	853215,	Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly  similar to human ataxin-2  interacts with Pab1p to regulate mRNA polyadenylation  interacts with Mkt1p to regulate HO translation
chrVII	853674	854895	853674	854895	-	OKP1	YGR179C		853674,	854895,	Outer kinetochore protein, required for accurate mitotic chromosome segregation  component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
chrVII	855263	856301	855263	856301	-	RNR4	YGR180C		855263,	856301,	Ribonucleotide-diphosphate reductase (RNR), small subunit  the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
chrVII	858286	858604	858286	858604	+	TIM13	YGR181W		858286,	858604,	Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
chrVII	858550	858904	858550	858904	-	YGR182C	YGR182C		858550,	858904,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF TIM13/YGR181W
chrVII	859062	859476	859062	859476	-	QCR9	YGR183C		859062,859473,	859260,859476,	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain  required for electron transfer at the ubiquinol oxidase site of the complex
chrVII	859900	865753	859900	865753	-	UBR1	YGR184C		859900,	865753,	E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway  regulates peptide transport via Cup9p ubiquitination  mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
chrVII	866335	867520	866335	867520	-	TYS1	YGR185C		866335,	867520,	Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis  interacts with positions 34 and 35 of the tRNATyr anticodon  mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies
chrVII	867773	869981	867773	869981	+	TFG1	YGR186W		867773,	869981,	TFIIF (Transcription Factor II) largest subunit  involved in both transcription initiation and elongation of RNA polymerase II  homologous to human RAP74
chrVII	870231	871416	870231	871416	-	HGH1	YGR187C		870231,	871416,	Nonessential protein of unknown function  predicted to be involved in ribosome biogenesis  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  similar to mammalian BRP16 (Brain protein 16)
chrVII	872043	875109	872043	875109	-	BUB1	YGR188C		872043,	875109,	Protein kinase involved in the cell cycle checkpoint into anaphase  forms complex with Mad1p and Bub3p crucial to preventing cell cycle progression into anaphase in the presence of spindle damage  CDC28-mediated phosphorylation at Bub1p-T566 is important for its degradation in anaphase and adaptation of the checkpoint to prolonged mitotic arrest, but not to its kinase activity or chromosome segregation function  associates with centromere DNA via Skp1p
chrVII	876668	878192	876668	878192	-	CRH1	YGR189C		876668,	878192,	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall  similar and functionally redundant to Utr2  localizes to sites of polarized growth  expression induced by cell wall stress
chrVII	880295	880661	880295	880661	-	YGR190C	YGR190C		880295,	880661,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene HIP1/YGR191W
chrVII	880419	882231	880419	882231	+	HIP1	YGR191W		880419,	882231,	High-affinity histidine permease, also involved in the transport of manganese ions
chrVII	882811	883810	882811	883810	-	TDH3	YGR192C		882811,	883810,	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis  tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate  detected in the cytoplasm and cell wall
chrVII	884508	885741	884508	885741	-	PDX1	YGR193C		884508,	885741,	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
chrVII	886072	887875	886072	887875	-	XKS1	YGR194C		886072,	887875,	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP  rate limiting step in fermentation of xylulose  required for xylose fermentation by recombinant S. cerevisiae strains
chrVII	888881	889622	888881	889622	+	SKI6	YGR195W		888881,	889622,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
chrVII	889732	892186	889732	892186	-	FYV8	YGR196C		889732,	892186,	Protein of unknown function, required for survival upon exposure to K1 killer toxin
chrVII	892496	894140	892496	894140	-	SNG1	YGR197C		892496,	894140,	Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU)  expression is regulated by transcription factors involved in multidrug resistance
chrVII	894692	897146	894692	897146	+	YPP1	YGR198W		894692,	897146,	Cargo-transport protein involved in endocytosis  interacts with phosphatidylinositol-4-kinase Stt4  GFP-fusion protein localizes to the cytoplasm  YGR198W is an essential gene
chrVII	897501	899781	897501	899781	+	PMT6	YGR199W		897501,	899781,	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins  reaction is essential for cell wall rigidity  member of a family of mannosyltransferases
chrVII	899903	902270	899903	902270	-	ELP2	YGR200C		899903,	902270,	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA  target of Kluyveromyces lactis zymocin
chrVII	902519	903197	902519	903197	-	YGR201C	YGR201C		902519,	903197,	Putative protein of unknown function
chrVII	903473	904748	903473	904748	-	PCT1	YGR202C		903473,	904748,	Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding
chrVII	905236	905683	905236	905683	+	YCH1	YGR203W		905236,	905683,	Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p  member of the single-domain rhodanese homology superfamily  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrVII	905933	908774	905933	908774	+	ADE3	YGR204W		905933,	908774,	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine  null mutation causes auxotrophy for adenine and histidine
chrVII	909060	909174	909060	909174	-	YGR204C-A	YGR204C-A		909060,	909174,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVII	909212	910085	909212	910085	+	YGR205W	YGR205W		909212,	910085,	ATP-binding protein of unknown function  crystal structure resembles that of E.coli pantothenate kinase and other small kinases  null mutant is sensitive to expression of the top1-T722A allele
chrVII	910431	910737	910431	910737	+	MVB12	YGR206W		910431,	910737,	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome  deletion mutant is sensitive to rapamycin and nystatin
chrVII	910842	911628	910842	911628	-	YGR207C	YGR207C		910842,	911628,	Mitochondrial protein that interacts with frataxin (Yfh1p)  putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta  may have a role in oxidative stress response
chrVII	911882	912812	911882	912812	+	SER2	YGR208W		911882,	912812,	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
chrVII	912912	913227	912912	913227	-	TRX2	YGR209C		912912,	913227,	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
chrVII	913502	914738	913502	914738	-	YGR210C	YGR210C		913502,	914738,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrVII	915240	916701	915240	916701	+	ZPR1	YGR211W		915240,	916701,	Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p  binds to translation elongation factor eEF-1 (Tef1p)
chrVII	917039	918446	917039	918446	+	SLI1	YGR212W		917039,	918446,	N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
chrVII	918511	919465	918511	919465	-	RTA1	YGR213C		918511,	919465,	Protein involved in 7-aminocholesterol resistance  has seven potential membrane-spanning regions  expression is induced under both low-heme and low-oxygen conditions  member of the fungal lipid-translocating exporter (LTE) family of protein
chrVII	920574	921788	920574	921788	+	RPS0A	YGR214W		920574,921119,	920664,921788,	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp  required for maturation of 18S rRNA along with Rps0Bp  deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
chrVII	922174	922507	922174	922507	+	RSM27	YGR215W		922174,	922507,	Mitochondrial ribosomal protein of the small subunit
chrVII	922632	924462	922632	924462	-	GPI1	YGR216C		922632,	924462,	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors  human and mouse GPI1p are functional homologs
chrVII	924695	930815	924695	930815	+	CCH1	YGR217W		924695,	930815,	Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones  interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
chrVII	932540	935795	932540	935795	+	CRM1	YGR218W		932540,	935795,	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus  exportin
chrVII	936034	936376	936034	936376	+	YGR219W	YGR219W		936034,	936376,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF MRPL9/YGR220C
chrVII	936073	936883	936073	936883	-	MRPL9	YGR220C		936073,	936883,	Mitochondrial ribosomal protein of the large subunit
chrVII	937123	938992	937123	938992	-	TOS2	YGR221C		937123,	938992,	Protein involved in localization of Cdc24p to the site of bud growth  may act as a membrane anchor  localizes to the bud neck and bud tip  potentially phosphorylated by Cdc28p
chrVII	939922	940804	939922	940804	+	PET54	YGR222W		939922,	940804,	Mitochondrial inner membrane protein  binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p  also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
chrVII	940868	942215	940868	942215	-	HSV2	YGR223C		940868,	942215,	Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy  predicted to fold as a seven-bladed beta-propeller  displays punctate cytoplasmic localization
chrVII	942805	944647	942805	944647	+	AZR1	YGR224W		942805,	944647,	Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
chrVII	945144	947019	945144	947019	+	AMA1	YGR225W		945144,946420,	946327,947019,	Activator of meiotic anaphase promoting complex (APC/C)  Cdc20p family member  required for initiation of spore wall assembly  required for Clb1p degradation during meiosis
chrVII	946791	947001	946791	947001	-	YGR226C	YGR226C		946791,	947001,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  overlaps significantly with a verified ORF, AMA1/YGR225W
chrVII	947419	948997	947419	948997	+	DIE2	YGR227W		947419,	948997,	Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
chrVII	949364	949709	949364	949709	+	YGR228W	YGR228W		949364,	949709,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF SMI1/YGR229C
chrVII	949381	950899	949381	950899	-	SMI1	YGR229C		949381,	950899,	Protein involved in the regulation of cell wall synthesis  proposed to be involved in coordinating cell cycle progression with cell wall integrity
chrVII	951893	952307	951893	952307	+	BNS1	YGR230W		951893,	952307,	Protein with some similarity to Spo12p  overexpression bypasses need for Spo12p, but not required for meiosis
chrVII	952547	953480	952547	953480	-	PHB2	YGR231C		952547,	953480,	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins  determinant of replicative life span  involved in mitochondrial segregation
chrVII	953959	954646	953959	954646	+	NAS6	YGR232W		953959,	954646,	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP)  ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
chrVII	954673	958210	954673	958210	-	PHO81	YGR233C		954673,	958210,	Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels  inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
chrVII	959903	961103	959903	961103	+	YHB1	YGR234W		959903,	961103,	Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification  plays a role in the oxidative and nitrosative stress responses
chrVII	961359	962061	961359	962061	-	YGR235C	YGR235C		961359,	962061,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	962529	962817	962529	962817	-	SPG1	YGR236C		962529,	962817,	Protein required for survival at high temperature during stationary phase  not required for growth on nonfermentable carbon sources  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	963297	965655	963297	965655	-	YGR237C	YGR237C		963297,	965655,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrVII	966038	968687	966038	968687	-	KEL2	YGR238C		966038,	968687,	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p  localizes to regions of polarized growth  potential Cdc28p substrate
chrVII	969186	970053	969186	970053	-	PEX21	YGR239C		969186,	970053,	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2  interacts with Pex7p  partially redundant with Pex18p
chrVII	970770	973734	970770	973734	-	PFK1	YGR240C		970770,	973734,	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
chrVII	974576	974777	974576	974777	-	YGR240C-A	YGR240C-A		974576,	974777,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrVII	974874	976581	974874	976581	-	YAP1802	YGR241C		974874,	976581,	Protein involved in clathrin cage assembly  binds Pan1p and clathrin  homologous to Yap1801p, member of the AP180 protein family
chrVII	976414	976723	976414	976723	+	YGR242W	YGR242W		976414,	976723,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YAP1802/YGR241C
chrVII	977335	977776	977335	977776	+	FMP43	YGR243W		977335,	977776,	Putative protein of unknown function  expression regulated by osmotic and alkaline stresses  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVII	978035	979319	978035	979319	-	LSC2	YGR244C		978035,	979319,	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
chrVII	979764	982068	979764	982068	-	SDA1	YGR245C		979764,	982068,	Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
chrVII	982481	984272	982481	984272	-	BRF1	YGR246C		982481,	984272,	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
chrVII	984965	985685	984965	985685	+	CPD1	YGR247W		984965,	985685,	Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate  may have a role in tRNA splicing  no detectable phenotype is conferred by null mutation or by overexpression
chrVII	985971	986739	985971	986739	+	SOL4	YGR248W		985971,	986739,	6-phosphogluconolactonase with similarity to Sol3p
chrVII	988048	989419	988048	989419	+	MGA1	YGR249W		988048,	989419,	Protein similar to heat shock transcription factor  multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
chrVII	991175	993521	991175	993521	-	YGR250C	YGR250C		991175,	993521,	Putative RNA binding protein  localizes to stress granules induced by glucose deprivation  interacts with Rbg1p in a two-hybrid
chrVII	995638	996229	995638	996229	+	YGR251W	YGR251W		995638,	996229,	Essential protein required for maturation of 18S rRNA  green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus
chrVII	996868	998188	996868	998188	+	GCN5	YGR252W		996868,	998188,	Acetyltransferase, modifies N-terminal lysines on histones H2B and H3  acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance  catalytic subunit of the ADA and SAGA histone acetyltransferase complexes  founding member of the Gcn5p-related N-acetyltransferase superfamily  mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
chrVII	998357	999140	998357	999140	-	PUP2	YGR253C		998357,	999140,	Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism  human homolog is subunit zeta
chrVII	1000926	1002240	1000926	1002240	+	ENO1	YGR254W		1000926,	1002240,	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis  expression is repressed in response to glucose
chrVII	1002522	1003962	1002522	1003962	-	COQ6	YGR255C		1002522,	1003962,	Putative flavin-dependent monooxygenase  involved in ubiquinone (Coenzyme Q) biosynthesis  localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes  human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
chrVII	1004623	1006102	1004623	1006102	+	GND2	YGR256W		1004623,	1006102,	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway  required for growth on D-glucono-delta-lactone
chrVII	1006204	1007305	1006204	1007305	-	MTM1	YGR257C		1006204,	1007305,	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
chrVII	1007670	1010766	1007670	1010766	-	RAD2	YGR258C		1007670,	1010766,	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA  subunit of Nucleotide Excision Repair Factor 3 (NEF3)  homolog of human XPG protein
chrVII	1012480	1012921	1012480	1012921	-	YGR259C	YGR259C		1012480,	1012921,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps almost completely with the verified ORF TNA1/YGR260W
chrVII	1012484	1014089	1012484	1014089	+	TNA1	YGR260W		1012484,	1014089,	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid  expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
chrVII	1014320	1016750	1014320	1016750	-	APL6	YGR261C		1014320,	1016750,	Beta3-like subunit of the yeast AP-3 complex  functions in transport of alkaline phosphatase to the vacuole via the alternate pathway  exists in both cytosolic and peripherally associated membrane-bound pools
chrVII	1016973	1017759	1016973	1017759	-	BUD32	YGR262C		1016973,	1017759,	Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p  EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
chrVII	1017966	1019241	1017966	1019241	-	SAY1	YGR263C		1017966,	1019241,	Sterol deacetylase  component of the sterol acetylation/deacetylation cycle along with Atf2p  integral membrane protein with active site in the ER lumen  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
chrVII	1019597	1021853	1019597	1021853	-	MES1	YGR264C		1019597,	1021853,	Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases  also has a role in nuclear export of tRNAs
chrVII	1021647	1022058	1021647	1022058	+	YGR265W	YGR265W		1021647,	1022058,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
chrVII	1022655	1024761	1022655	1024761	+	YGR266W	YGR266W		1022655,	1024761,	Protein of unknown function, predicted to contain a single transmembrane domain  mutant has increased aneuploidy tolerance  localized to both the mitochondrial outer membrane and the plasma membrane
chrVII	1025003	1025735	1025003	1025735	-	FOL2	YGR267C		1025003,	1025735,	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
chrVII	1026056	1026653	1026056	1026653	-	HUA1	YGR268C		1026056,	1026653,	Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins  computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
chrVII	1026635	1026962	1026635	1026962	+	YGR269W	YGR269W		1026635,	1026962,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF HUA1/YGR268C
chrVII	1027369	1031509	1027369	1031509	+	YTA7	YGR270W		1027369,	1031509,	Protein that localizes to chromatin and has a role in regulation of histone gene expression  has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain  potentially phosphorylated by Cdc28p
chrVII	1027381	1027600	1027381	1027600	-	YGR270C-A	YGR270C-A		1027381,	1027600,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF YTA7/YGR270W
chrVII	1031790	1037694	1031790	1037694	+	SLH1	YGR271W		1031790,	1037694,	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs  required for repressing propagation of dsRNA viruses
chrVII	1037799	1038501	1037799	1038501	-	EFG1	YGR271C-A		1037799,	1038501,	Essential protein required for maturation of 18S rRNA  null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest  green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
chrVII	1038714	1039239	1038714	1039239	-	YGR273C	YGR273C		1038714,	1039239,	Putative protein of unknown function  expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation  YGR273C is not an essential gene
chrVII	1039894	1043095	1039894	1043095	-	TAF1	YGR274C		1039894,	1043095,	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation  possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor  involved in promoter binding and G1/S progression
chrVII	1043275	1043749	1043275	1043749	+	RTT102	YGR275W		1043275,	1043749,	Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance  possible weak regulator of Ty1 transposition
chrVII	1043818	1045480	1043818	1045480	-	RNH70	YGR276C		1043818,	1045480,	3'-5' exoribonuclease  required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts
chrVII	1045643	1046561	1045643	1046561	-	CAB4	YGR277C		1045643,	1046561,	Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate  null mutant lethality is complemented by E. coli coaD (encoding PPAT)  widely conserved
chrVII	1046730	1048464	1046730	1048464	+	CWC22	YGR278W		1046730,	1048464,	Spliceosome-associated protein that is required for pre-mRNA splicing  necessary for Prp2p function at the first catalytic step of splicing  has similarity to S. pombe Cwf22p  CWC22 is an essential protein
chrVII	1048797	1049958	1048797	1049958	-	SCW4	YGR279C		1048797,	1049958,	Cell wall protein with similarity to glucanases  scw4 scw10 double mutants exhibit defects in mating
chrVII	1050909	1051725	1050909	1051725	-	PXR1	YGR280C		1050909,	1051725,	Essential protein involved in rRNA and snoRNA maturation  competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase  human homolog inhibits telomerase  contains a G-patch RNA interacting domain
chrVII	1052823	1057257	1052823	1057257	+	YOR1	YGR281W		1052823,	1057257,	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin  similar to human cystic fibrosis transmembrane receptor (CFTR)
chrVII	1057782	1058724	1057782	1058724	-	BGL2	YGR282C		1057782,	1058724,	Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
chrVII	1059014	1060040	1059014	1060040	-	YGR283C	YGR283C		1059014,	1060040,	Protein of unknown function  may interact with ribosomes, based on co-purification experiments  predicted to be involved in ribosome biogenesis  null mutant is resistant to fluconazole  GFP-fusion protein localizes to the nucleolus
chrVII	1060657	1061590	1060657	1061590	-	ERV29	YGR284C		1060657,	1061590,	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
chrVII	1061851	1063153	1061851	1063153	-	ZUO1	YGR285C		1061851,	1063153,	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains  contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
chrVII	1063812	1064940	1063812	1064940	-	BIO2	YGR286C		1063812,	1064940,	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway  complements E. coli bioB mutant
chrVII	1067221	1068991	1067221	1068991	-	IMA1	YGR287C		1067221,	1068991,	Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization  has specificity for isomaltose, palatinose, and methyl-alpha-glucoside  member of the IMA isomaltase family
chrVII	1070292	1071714	1070292	1071714	+	MAL13	YGR288W		1070292,	1071714,	MAL-activator protein, part of complex locus MAL1  nonfunctional in genomic reference strain S288C
chrVII	1073962	1075813	1073962	1075813	-	MAL11	YGR289C		1073962,	1075813,	Inducible high-affinity maltose transporter (alpha-glucoside transporter)  encoded in the MAL1 complex locus  broad substrate specificity that includes maltotriose  required for isomaltose utilization
chrVII	1075481	1075925	1075481	1075925	+	YGR290W	YGR290W		1075481,	1075925,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  putative HLH protein  partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
chrVII	1076282	1076504	1076282	1076504	-	YGR291C	YGR291C		1076282,	1076504,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrVII	1076598	1078353	1076598	1078353	+	MAL12	YGR292W		1076598,	1078353,	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism  encoded in the MAL1 complex locus  hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
chrVII	1079884	1080346	1079884	1080346	-	YGR293C	YGR293C		1079884,	1080346,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YGR294W
chrVII	1080305	1080668	1080305	1080668	+	PAU12	YGR294W		1080305,	1080668,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
chrVII	1081583	1082729	1081583	1082729	-	COS6	YGR295C		1081583,	1082729,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrVII	1084863	1090591	1084863	1090591	+	YRF1-3	YGR296W		1084863,1085030,	1084882,1090591,	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1  potentially phosphorylated by Cdc28p
chrVII	1088869	1089445	1088869	1089445	-	YGR296C-A	YGR296C-A		1088869,	1089445,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps TEL07R
chrVII	1089745	1090228	1089745	1090228	-	YGR296C-B	YGR296C-B		1089745,	1090228,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  contained completely within TEL07R
chrVIII	444	3311	444	3311	-	YHL050C	YHL050C		444,2670,	1897,3311,	Putative protein of unknown function, potential Cdc28p substrate
chrVIII	810	1293	810	1293	+	YHL050W-A	YHL050W-A		810,	1293,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVIII	3725	4541	3725	4541	-	YHL049C	YHL049C		3725,	4541,	Putative protein of unknown function
chrVIII	5662	5797	5662	5797	-	YHL048C-A	YHL048C-A		5662,	5797,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrVIII	6400	7546	6400	7546	+	COS8	YHL048W		6400,	7546,	Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins  regulation suggests a potential role in the unfolded protein response
chrVIII	8350	10213	8350	10213	-	ARN2	YHL047C		8350,	10213,	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates  responsible for uptake of iron bound to the siderophore triacetylfusarinine C
chrVIII	9980	10307	9980	10307	+	YHL046W-A	YHL046W-A		9980,	10307,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	11922	12285	11922	12285	-	PAU13	YHL046C		11922,	12285,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions  expression is induced after ethanol shock
chrVIII	12501	12849	12501	12849	+	YHL045W	YHL045W		12501,	12849,	Putative protein of unknown function  not an essential gene
chrVIII	13564	14272	13564	14272	+	YHL044W	YHL044W		13564,	14272,	Putative integral membrane protein, member of DUP240 gene family  green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
chrVIII	14900	15413	14900	15413	+	ECM34	YHL043W		14900,	15413,	Putative protein of unknown function  member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrVIII	15666	16119	15666	16119	+	YHL042W	YHL042W		15666,	16119,	Putative protein of unknown function  member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrVIII	17391	17841	17391	17841	+	YHL041W	YHL041W		17391,	17841,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrVIII	19087	20971	19087	20971	-	ARN1	YHL040C		19087,	20971,	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates  responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
chrVIII	21782	23540	21782	23540	+	EFM1	YHL039W		21782,	23540,	Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p)  SET-domain family member  predicted involvement in ribosome biogenesis  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrVIII	23616	25509	23616	25509	-	CBP2	YHL038C		23616,	25509,	Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing  also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
chrVIII	25777	26179	25777	26179	-	YHL037C	YHL037C		25777,	26179,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	26240	27881	26240	27881	+	MUP3	YHL036W		26240,	27881,	Low affinity methionine permease, similar to Mup1p
chrVIII	27977	32756	27977	32756	-	VMR1	YHL035C		27977,	32756,	Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity  ATP-binding cassette (ABC) family member involved in drug transport  potential Cdc28p substrate  induced under respiratory conditions
chrVIII	33175	33637	33175	33637	+	YHL034W-A	YHL034W-A		33175,	33637,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	33192	34077	33192	34077	-	SBP1	YHL034C		33192,	34077,	Putative RNA binding protein  involved in translational repression and found in cytoplasmic P bodies  found associated with small nucleolar RNAs snR10 and snR11
chrVIII	35254	36025	35254	36025	-	RPL8A	YHL033C		35254,	36025,	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein  mutation results in decreased amounts of free 60S subunits
chrVIII	36378	38508	36378	38508	-	GUT1	YHL032C		36378,	38508,	Glycerol kinase, converts glycerol to glycerol-3-phosphate  glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p  derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
chrVIII	38814	39486	38814	39486	-	GOS1	YHL031C		38814,	39486,	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
chrVIII	39073	39535	39073	39535	+	YHL030W-A	YHL030W-A		39073,	39535,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene GOS1/YHL031C
chrVIII	40083	45690	40083	45690	+	ECM29	YHL030W		40083,	45690,	Scaffold protein that assists in association of the proteasome core particle with the regulatory particle  degraded by the mature proteasome after assembly  contains HEAT-like repeats
chrVIII	45928	47968	45928	47968	-	OCA5	YHL029C		45928,	47968,	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
chrVIII	48762	50580	48762	50580	+	WSC4	YHL028W		48762,	50580,	ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane  may also have a role in the stress response but has only partial functional overlap with WSC1-3
chrVIII	51110	52988	51110	52988	+	RIM101	YHL027W		51110,	52988,	Transcriptional repressor involved in response to pH and in cell wall construction  required for alkaline pH-stimulated haploid invasive growth and sporulation  activated by proteolytic processing  similar to A. nidulans PacC
chrVIII	53218	54166	53218	54166	-	YHL026C	YHL026C		53218,	54166,	Putative protein of unknown function  transcriptionally regulated by Upc2p via an upstream sterol response element  YHL026C is not an essential gene  in 2005 the start site was moved 141 nt upstream (see Locus History)
chrVIII	54850	55849	54850	55849	+	SNF6	YHL025W		54850,	55849,	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation  functions interdependently in transcriptional activation with Snf2p and Snf5p
chrVIII	56648	58790	56648	58790	+	RIM4	YHL024W		56648,	58790,	Putative RNA-binding protein required for the expression of early and middle sporulation genes
chrVIII	59122	62563	59122	62563	-	NPR3	YHL023C		59122,	62563,	Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation  subunit of SEA (Seh1-associated) complex  null mutant displays delayed meiotic DNA replication and double-strand break repair
chrVIII	62960	64157	62960	64157	-	SPO11	YHL022C		62960,	64157,	Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction  required for homologous chromosome pairing and synaptonemal complex formation
chrVIII	64461	65859	64461	65859	-	AIM17	YHL021C		64461,	65859,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  null mutant displays reduced frequency of mitochondrial genome loss
chrVIII	66241	67456	66241	67456	-	OPI1	YHL020C		66241,	67456,	Transcriptional regulator of a variety of genes  phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes  involved in telomere maintenance
chrVIII	67710	68304	67710	68304	+	YHL019W-A	YHL019W-A		67710,	68304,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene APM2/YHL019C
chrVIII	67730	69548	67730	69548	-	APM2	YHL019C		67730,	69548,	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex  involved in vesicular transport
chrVIII	69707	70070	69707	70070	+	YHL018W	YHL018W		69707,	70070,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
chrVIII	70275	71874	70275	71874	+	YHL017W	YHL017W		70275,	71874,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles
chrVIII	72036	74244	72036	74244	-	DUR3	YHL016C		72036,	74244,	Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
chrVIII	74698	74782	74698	74782	+	YHL015W-A	YHL015W-A		74698,	74782,	Putative protein of unknown function
chrVIII	75411	75777	75411	75777	+	RPS20	YHL015W		75411,	75777,	Protein component of the small (40S) ribosomal subunit  overproduction suppresses mutations affecting RNA polymerase III-dependent transcription  has similarity to E. coli S10 and rat S20 ribosomal proteins
chrVIII	76096	77314	76096	77314	-	YLF2	YHL014C		76096,	77314,	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVIII	77429	78353	77429	78353	-	OTU2	YHL013C		77429,	78353,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases  shows cytoplasmic localization
chrVIII	78935	80417	78935	80417	+	YHL012W	YHL012W		78935,	80417,	Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase
chrVIII	80653	81616	80653	81616	-	PRS3	YHL011C		80653,	81616,	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis  one of five related enzymes, which are active as heteromultimeric complexes
chrVIII	81963	83721	81963	83721	-	ETP1	YHL010C		81963,	83721,	Putative protein of unknown function that is required for growth on ethanol  contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
chrVIII	84067	85060	84067	85060	-	YAP3	YHL009C		84067,	85060,	Basic leucine zipper (bZIP) transcription factor
chrVIII	85908	91318	85908	91318	+	YHL009W-B	YHL009W-B		85908,86995,	86994,91318,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVIII	85908	87150	85908	87150	+	YHL009W-A	YHL009W-A		85908,	87150,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVIII	92626	94510	92626	94510	-	YHL008C	YHL008C		92626,	94510,	Putative protein of unknown function, may be involved in the uptake of chloride ions  does not appear to be involved in monocarboxylic acid transport  green fluorescent protein (GFP)-fusion protein localizes to the vacuole
chrVIII	95117	97937	95117	97937	-	STE20	YHL007C		95117,	97937,	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family  involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake  GBB motif binds Ste4p
chrVIII	97731	98085	97731	98085	+	YHL006W-A	YHL006W-A		97731,	98085,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	98342	98795	98342	98795	-	SHU1	YHL006C		98342,	98795,	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation  associates with Shu2p, Psy3p, and Csm2p
chrVIII	98827	99220	98827	99220	-	YHL005C	YHL005C		98827,	99220,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YHL004W
chrVIII	99218	100403	99218	100403	+	MRP4	YHL004W		99218,	100403,	Mitochondrial ribosomal protein of the small subunit
chrVIII	100647	101883	100647	101883	-	LAG1	YHL003C		100647,	101883,	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
chrVIII	102586	103075	102586	103075	-	YHL002C-A	YHL002C-A		102586,	103075,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	102611	103970	102611	103970	+	HSE1	YHL002W		102611,	103970,	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
chrVIII	104276	105091	104276	105091	+	RPL14B	YHL001W		104276,104803,	104405,105091,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
chrVIII	106054	107368	106054	107368	+	OSH7	YHR001W		106054,	107368,	Member of an oxysterol-binding protein family with seven members in S. cerevisiae  family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
chrVIII	107825	108122	107825	108122	+	QCR10	YHR001W-A		107825,107894,	107831,108122,	Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
chrVIII	108811	109885	108811	109885	+	LEU5	YHR002W		108811,	109885,	Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix  homolog of human Graves disease protein  does not encode an isozyme of Leu4p, as first hypothesized
chrVIII	110027	111317	110027	111317	-	YHR003C	YHR003C		110027,	111317,	Protein of unknown function, localized to the mitochondrial outer membrane
chrVIII	111753	113094	111753	113094	-	NEM1	YHR004C		111753,	113094,	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme  regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation  homolog of the human protein Dullard
chrVIII	113498	114917	113498	114917	-	GPA1	YHR005C		113498,	114917,	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors  negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response  activates Vps34p at the endosome
chrVIII	115619	115901	115619	115901	-	TIM10	YHR005C-A		115619,	115901,	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
chrVIII	117813	119439	117813	119439	+	STP2	YHR006W		117813,	119439,	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids  activates transcription of amino acid permease genes
chrVIII	120090	121683	120090	121683	-	ERG11	YHR007C		120090,	121683,	Lanosterol 14-alpha-demethylase  catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway  member of the cytochrome P450 family  associated and coordinately regulated with the P450 reductase Ncp1p
chrVIII	122549	122765	122549	122765	-	YHR007C-A	YHR007C-A		122549,	122765,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrVIII	122888	123590	122888	123590	-	SOD2	YHR008C		122888,	123590,	Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity  phosphorylated
chrVIII	124108	125680	124108	125680	-	YHR009C	YHR009C		124108,	125680,	Putative oxidoreductase involved in late endosome to Golgi transport  physical and genetical interactions with Btn2p  null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele  similar to human FOXRED1
chrVIII	126520	127492	126520	127492	+	RPL27A	YHR010W		126520,127112,	126551,127492,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
chrVIII	127779	129120	127779	129120	+	DIA4	YHR011W		127779,	129120,	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
chrVIII	129480	130448	129480	130448	+	VPS29	YHR012W		129480,129647,	129528,130448,	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport  forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
chrVIII	130729	131446	130729	131446	-	ARD1	YHR013C		130729,	131446,	Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p)  acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation  human Ard1p levels are elevated in cancer cells
chrVIII	132046	132922	132046	132922	+	SPO13	YHR014W		132046,	132922,	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
chrVIII	134553	136533	134553	136533	+	MIP6	YHR015W		134553,	136533,	Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
chrVIII	136880	138455	136880	138455	-	YSC84	YHR016C		136880,138408,	138240,138455,	Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches  activity stimulated by Las17p  contains SH3 domain similar to Rvs167p
chrVIII	138693	139851	138693	139851	+	YSC83	YHR017W		138693,	139851,	Non-essential mitochondrial protein of unknown function  mRNA induced during meiosis, peaking between mid to late prophase of meiosis I  similar to S. douglasii YSD83
chrVIII	140010	141402	140010	141402	-	ARG4	YHR018C		140010,	141402,	Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
chrVIII	141893	143558	141893	143558	-	DED81	YHR019C		141893,	143558,	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
chrVIII	143995	146062	143995	146062	+	YHR020W	YHR020W		143995,	146062,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  has similarity to proline-tRNA ligase  YHR020W is an essential gene
chrVIII	147870	148669	147870	148669	-	RPS27B	YHR021C		147870,148666,	148116,148669,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
chrVIII	149224	149680	149224	149680	+	ECM12	YHR021W-A		149224,	149680,	Putative protein of unknown function  may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
chrVIII	149574	150345	149574	150345	-	YHR022C	YHR022C		149574,	150345,	Putative protein of unknown function  YHR022C is not an essential gene
chrVIII	151216	151306	151216	151306	-	YHR022C-A	YHR022C-A		151216,	151306,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVIII	151665	157452	151665	157452	+	MYO1	YHR023W		151665,	157452,	Type II myosin heavy chain, required for wild-type cytokinesis and cell separation  localizes to the actomyosin ring  binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
chrVIII	157743	159192	157743	159192	-	MAS2	YHR024C		157743,	159192,	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
chrVIII	159437	160511	159437	160511	+	THR1	YHR025W		159437,	160511,	Homoserine kinase, conserved protein required for threonine biosynthesis  expression is regulated by the GCN4-mediated general amino acid control pathway
chrVIII	160843	161485	160843	161485	+	VMA16	YHR026W		160843,	161485,	Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole  one of three proteolipid subunits of the V0 domain
chrVIII	161729	164711	161729	164711	-	RPN1	YHR027C		161729,	164711,	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome  may participate in the recognition of several ligands of the proteasome  contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions
chrVIII	164977	167434	164977	167434	-	DAP2	YHR028C		164977,	167434,	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor  localizes to the vacuolar membrane  similar to Ste13p
chrVIII	167351	167672	167351	167672	+	YHR028W-A	YHR028W-A		167351,	167672,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	167676	168561	167676	168561	-	YHI9	YHR029C		167676,	168561,	Protein of unknown function  null mutant is defective in unfolded protein response  possibly involved in a membrane regulation metabolic pathway  member of the PhzF superfamily, though most likely not involved in phenazine production
chrVIII	168889	170344	168889	170344	-	SLT2	YHR030C		168889,	170344,	Serine/threonine MAP kinase  involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock  required for mitophagy and pexophagy  affects recruitment of mitochondria to the phagophore assembly site (PAS)  regulated by the PKC1-mediated signaling pathway
chrVIII	170798	172970	170798	172970	-	RRM3	YHR031C		170798,	172970,	DNA helicase involved in rDNA replication and Ty1 transposition  relieves replication fork pauses at telomeric regions  structurally and functionally related to Pif1p
chrVIII	173343	175089	173343	175089	+	ERC1	YHR032W		173343,	175089,	Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily  overproduction confers ethionine resistance and accumulation of S-adenosylmethionine
chrVIII	175194	175374	175194	175374	+	YHR032W-A	YHR032W-A		175194,	175374,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YHR032C-A
chrVIII	175274	175394	175274	175394	-	YHR032C-A	YHR032C-A		175274,	175394,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YHR032W-A
chrVIII	175547	176819	175547	176819	+	YHR033W	YHR033W		175547,	176819,	Putative protein of unknown function  epitope-tagged protein localizes to the cytoplasm
chrVIII	176964	177999	176964	177999	-	PIH1	YHR034C		176964,	177999,	Protein of unresolved function  may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)
chrVIII	178218	180111	178218	180111	+	YHR035W	YHR035W		178218,	180111,	Putative protein of unknown function  not an essential gene
chrVIII	180344	181760	180344	181760	+	BRL1	YHR036W		180344,	181760,	Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1  homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
chrVIII	181976	183704	181976	183704	+	PUT2	YHR037W		181976,	183704,	Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source  deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
chrVIII	184065	184758	184065	184758	+	RRF1	YHR038W		184065,	184758,	Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
chrVIII	184874	186809	184874	186809	-	MSC7	YHR039C		184874,	186809,	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
chrVIII	187172	187679	187172	187679	-	VMA10	YHR039C-A		187172,187676,	187514,187679,	Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system  involved in vacuolar acidification
chrVIII	187923	189024	187923	189024	+	BCD1	YHR040W		187923,	189024,	Essential protein required for the accumulation of box C/D snoRNA
chrVIII	189130	189864	189130	189864	-	SRB2	YHR041C		189130,189850,	189749,189864,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  general transcription factor involved in telomere maintenance
chrVIII	190542	192618	190542	192618	+	NCP1	YHR042W		190542,	192618,	NADP-cytochrome P450 reductase  involved in ergosterol biosynthesis  associated and coordinately regulated with Erg11p
chrVIII	192804	193545	192804	193545	-	DOG2	YHR043C		192804,	193545,	2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
chrVIII	194067	194808	194067	194808	-	DOG1	YHR044C		194067,	194808,	2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases  confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
chrVIII	195550	197233	195550	197233	+	YHR045W	YHR045W		195550,	197233,	Putative protein of unknown function  possible role in iron metabolism and/or amino acid and carbohydrate metabolism  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
chrVIII	197397	198285	197397	198285	-	INM1	YHR046C		197397,	198285,	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling  INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
chrVIII	198739	201310	198739	201310	-	AAP1	YHR047C		198739,	201310,	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
chrVIII	204606	206151	204606	206151	+	YHK8	YHR048W		204606,	206151,	Presumed antiporter of the DHA1 family of multidrug resistance transporters  contains 12 predicted transmembrane spans  expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
chrVIII	206461	207193	206461	207193	+	FSH1	YHR049W		206461,	207193,	Putative serine hydrolase that localizes to both the nucleus and cytoplasm  sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2
chrVIII	207233	207530	207233	207530	-	YHR049C-A	YHR049C-A		207233,	207530,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	207653	209303	207653	209303	+	SMF2	YHR050W		207653,	209303,	Divalent metal ion transporter involved in manganese homeostasis  has broad specificity for di-valent and tri-valent metals  post-translationally regulated by levels of metal ions  member of the Nramp family of metal transport proteins
chrVIII	209474	209645	209474	209645	+	YHR050W-A	YHR050W-A		209474,	209645,	Protein of unknown function  identified by expression profiling and mass spectrometry
chrVIII	209704	210151	209704	210151	+	COX6	YHR051W		209704,	210151,	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  expression is regulated by oxygen levels
chrVIII	210847	211978	210847	211978	+	CIC1	YHR052W		210847,	211978,	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity  also copurifies with 66S pre-ribosomal particles
chrVIII	212509	212704	212509	212704	+	YHR052W-A	YHR052W-A		212509,	212704,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps CUP1-1
chrVIII	212534	212720	212534	212720	-	CUP1-1	YHR053C		212534,	212720,	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium  locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
chrVIII	213184	214249	213184	214249	-	YHR054C	YHR054C		213184,	214249,	Putative protein of unknown function
chrVIII	214507	214702	214507	214702	+	YHR054W-A	YHR054W-A		214507,	214702,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps CUP1-2
chrVIII	214532	214718	214532	214718	-	CUP1-2	YHR055C		214532,	214718,	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium  locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
chrVIII	215182	217834	215182	217834	-	RSC30	YHR056C		215182,	217834,	Component of the RSC chromatin remodeling complex  non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response  highly similar to Rsc3p  null mutants are osmosensitive
chrVIII	217405	217840	217405	217840	+	YHR056W-A	YHR056W-A		217405,	217840,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	218225	218843	218225	218843	-	CPR2	YHR057C		218225,	218843,	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  has a potential role in the secretory pathway
chrVIII	218996	219884	218996	219884	-	MED6	YHR058C		218996,	219884,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation
chrVIII	220107	220500	220107	220500	+	FYV4	YHR059W		220107,	220500,	Protein of unknown function, required for survival upon exposure to K1 killer toxin
chrVIII	220724	221270	220724	221270	+	VMA22	YHR060W		220724,	221270,	Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex  functions in the assembly of the V-ATPase  localized to the yeast endoplasmic reticulum (ER)
chrVIII	221533	222478	221533	222478	-	GIC1	YHR061C		221533,	222478,	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
chrVIII	222876	223758	222876	223758	-	RPP1	YHR062C		222876,	223758,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
chrVIII	224029	225169	224029	225169	-	PAN5	YHR063C		224029,	225169,	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
chrVIII	225441	225777	225441	225777	+	YHR063W-A	YHR063W-A		225441,	225777,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	225524	227141	225524	227141	-	SSZ1	YHR064C		225524,	227141,	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit  also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5  binds ATP
chrVIII	227531	229037	227531	229037	-	RRP3	YHR065C		227531,	229037,	Protein involved in rRNA processing  required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA  homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
chrVIII	229334	230696	229334	230696	+	SSF1	YHR066W		229334,	230696,	Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation  functionally redundant with Ssf2p  member of the Brix family
chrVIII	230969	231812	230969	231812	+	HTD2	YHR067W		230969,	231812,	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
chrVIII	232132	233296	232132	233296	+	DYS1	YHR068W		232132,	233296,	Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis  triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels  tetrameric
chrVIII	233578	234658	233578	234658	-	RRP4	YHR069C		233578,	234658,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  predicted to contain RNA binding domains  has similarity to human hRrp4p (EXOSC2)
chrVIII	234873	235236	234873	235236	-	YHR069C-A	YHR069C-A		234873,	235236,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	234880	236380	234880	236380	+	TRM5	YHR070W		234880,	236380,	tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting  highly conserved across Archaea, Bacteria, and Eukarya
chrVIII	236101	236512	236101	236512	-	YHR070C-A	YHR070C-A		236101,	236512,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene TRM5/YHR070W
chrVIII	237003	237693	237003	237693	+	PCL5	YHR071W		237003,	237693,	Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
chrVIII	238909	239230	238909	239230	-	YHR071C-A	YHR071C-A		238909,	239230,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF ERG7/YHR072W
chrVIII	239097	241293	239097	241293	+	ERG7	YHR072W		239097,	241293,	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
chrVIII	241663	241840	241663	241840	+	NOP10	YHR072W-A		241663,	241840,	Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA
chrVIII	242581	245572	242581	245572	+	OSH3	YHR073W		242581,	245572,	Member of an oxysterol-binding protein family with seven members in S. cerevisiae  family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
chrVIII	242867	243044	242867	243044	+	YHR073W-A	YHR073W-A		242867,	243044,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF YHR073W  identified by expression profiling and mass spectrometry
chrVIII	245421	245502	245421	245502	-	YHR073C-B	YHR073C-B		245421,	245502,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF YHR073W  identified by expression profiling and mass spectrometry
chrVIII	246192	248337	246192	248337	+	QNS1	YHR074W		246192,	248337,	Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
chrVIII	248438	249641	248438	249641	-	PPE1	YHR075C		248438,	249641,	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit  also identified as a small subunit mitochondrial ribosomal protein
chrVIII	251100	252225	251100	252225	+	PTC7	YHR076W		251100,251248,	251155,252225,	Type 2C protein phosphatase (PP2C)  alternatively spliced to create two mRNA isoforms  protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
chrVIII	252373	255756	252373	255756	-	NMD2	YHR077C		252373,255750,	255637,255756,	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway  interacts with Nam7p and Upf3p  involved in telomere maintenance
chrVIII	256359	258018	256359	258018	+	YHR078W	YHR078W		256359,	258018,	High osmolarity-regulated gene of unknown function
chrVIII	258243	261591	258243	261591	-	IRE1	YHR079C		258243,	261591,	Serine-threonine kinase and endoribonuclease  transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing  Kar2p binds inactive Ire1p and releases from it upon ER stress
chrVIII	262191	262553	262191	262553	-	SAE3	YHR079C-A		262191,262440,	262354,262553,	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p  proposed to be an assembly factor for Dmc1p
chrVIII	262800	266838	262800	266838	-	YHR080C	YHR080C		262800,	266838,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrVIII	267537	268092	267537	268092	+	LRP1	YHR081W		267537,	268092,	Nuclear exosome-associated nucleic acid binding protein  involved in RNA processing, surveillance, degradation, tethering, and export  homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
chrVIII	268458	271548	268458	271548	-	KSP1	YHR082C		268458,	271548,	Ser/thr protein kinase  nuclear translocation required for haploid filamentous growth  regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p  overproduction causes allele-specific suppression of prp20-10
chrVIII	272626	273616	272626	273616	+	SAM35	YHR083W		272626,	273616,	Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
chrVIII	274173	276240	274173	276240	+	STE12	YHR084W		274173,	276240,	Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways  cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
chrVIII	276763	277768	276763	277768	+	IPI1	YHR085W		276763,	277768,	Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA  Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
chrVIII	278152	279724	278152	279724	+	NAM8	YHR086W		278152,	279724,	RNA binding protein, component of the U1 snRNP protein  mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA  Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2  the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
chrVIII	280230	280392	280230	280392	+	YHR086W-A	YHR086W-A		280230,	280392,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrVIII	280819	281155	280819	281155	+	RTC3	YHR087W		280819,	281155,	Protein of unknown function involved in RNA metabolism  has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1)  null mutation suppresses cdc13-1 temperature sensitivity
chrVIII	281494	282382	281494	282382	+	RPF1	YHR088W		281494,	282382,	Nucleolar protein involved in the assembly and export of the large ribosomal subunit  constituent of 66S pre-ribosomal particles  contains a sigma(70)-like motif, which is thought to bind RNA
chrVIII	282680	283298	282680	283298	-	GAR1	YHR089C		282680,	283298,	Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
chrVIII	283776	284625	283776	284625	-	YNG2	YHR090C		283776,	284625,	Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A  has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5
chrVIII	284838	286770	284838	286770	-	MSR1	YHR091C		284838,	286770,	Mitochondrial arginyl-tRNA synthetase
chrVIII	287080	288811	287080	288811	-	HXT4	YHR092C		287080,	288811,	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
chrVIII	289141	289690	289141	289690	+	AHT1	YHR093W		289141,	289690,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
chrVIII	290912	292625	290912	292625	-	HXT1	YHR094C		290912,	292625,	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
chrVIII	292942	293437	292942	293437	+	YHR095W	YHR095W		292942,	293437,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	294668	296447	294668	296447	-	HXT5	YHR096C		294668,	296447,	Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
chrVIII	297384	298609	297384	298609	-	YHR097C	YHR097C		297384,298484,	298360,298609,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
chrVIII	299144	301934	299144	301934	-	SFB3	YHR098C		299144,	301934,	Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport  homologous to Sec24p and Sfb2p
chrVIII	302760	313995	302760	313995	+	TRA1	YHR099W		302760,	313995,	Subunit of SAGA and NuA4 histone acetyltransferase complexes  interacts with acidic activators (e.g., Gal4p) which leads to transcription activation  similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
chrVIII	314115	314673	314115	314673	-	GEP4	YHR100C		314115,	314673,	Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis  null mutant is sensitive to tunicamycin, DTT
chrVIII	314873	315968	314873	315968	-	BIG1	YHR101C		314873,315858,	315771,315968,	Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
chrVIII	316571	319814	316571	319814	+	KIC1	YHR102W		316571,	319814,	Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall  physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
chrVIII	320413	322972	320413	322972	+	SBE22	YHR103W		320413,	322972,	Protein involved in the transport of cell wall components from the Golgi to the cell surface  similar in structure and functionally redundant with Sbe2p  involved in bud growth
chrVIII	323408	324392	323408	324392	+	GRE3	YHR104W		323408,	324392,	Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism  stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals)  regulated by the HOG pathway
chrVIII	324765	325410	324765	325410	+	YPT35	YHR105W		324765,	325410,	Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
chrVIII	325597	326626	325597	326626	+	TRR2	YHR106W		325597,	326626,	Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p  contains active-site motif (CAVC) present in prokaryotic orthologs  binds NADPH and FAD
chrVIII	326812	328036	326812	328036	-	CDC12	YHR107C		326812,	328036,	Component of the septin ring of the mother-bud neck that is required for cytokinesis  septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
chrVIII	328302	330060	328302	330060	+	GGA2	YHR108W		328302,	330060,	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi  binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization  has homology to gamma-adaptin
chrVIII	330309	332067	330309	332067	+	CTM1	YHR109W		330309,	332067,	Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol  not required for normal respiratory growth
chrVIII	332281	332920	332281	332920	+	ERP5	YHR110W		332281,	332920,	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
chrVIII	333071	334394	333071	334394	+	UBA4	YHR111W		333071,	334394,	Protein that activates Urm1p before its conjugation to proteins (urmylation)  also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p  receives sulfur from Tum1p
chrVIII	334526	335663	334526	335663	-	YHR112C	YHR112C		334526,	335663,	Protein of unknown function  localizes to the cytoplasm and nucleus  overexpression affects protein trafficking through the endocytic pathway
chrVIII	336336	337809	336336	337809	+	YHR113W	YHR113W		336336,	337809,	Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole  CVT pathway cargo protein  cleaves unblocked N-terminal acidic amino acids from peptide substrates  forms a 12-subunit homo-oligomer  M18 metalloprotease family
chrVIII	338082	339984	338082	339984	+	BZZ1	YHR114W		338082,	339984,	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
chrVIII	340108	341359	340108	341359	-	DMA1	YHR115C		340108,	341359,	Protein involved in ubiquitin ligation  plays a role in regulating spindle position and orientation  functionally redundant with Dma2p  orthologous to human RNF8 protein, also has sequence similarity to human Chfr.
chrVIII	341664	342120	341664	342120	+	COX23	YHR116W		341664,	342120,	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression  homologous to Cox17p  contains twin cysteine-x9-cysteine motifs
chrVIII	342348	344268	342348	344268	+	TOM71	YHR117W		342348,	344268,	Mitochondrial outer membrane protein with similarity to Tom70p  probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins
chrVIII	344320	345628	344320	345628	-	ORC6	YHR118C		344320,	345628,	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing  phosphorylated by Cdc28p
chrVIII	346042	349285	346042	349285	+	SET1	YHR119W		346042,	349285,	Histone methyltransferase, subunit of the COMPASS (Set1C) complex  COMPASS methylates histone H3K4  Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway  modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination  required in transcriptional silencing near telomeres and at silent mating type loci  has a SET domain
chrVIII	349573	352453	349573	352453	+	MSH1	YHR120W		349573,	352453,	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches  has homology to E. coli MutS  transcription is induced during meiosis
chrVIII	352755	353319	352755	353319	+	LSM12	YHR121W		352755,	353319,	Protein of unknown function that may function in RNA processing  interacts with Pbp1p and Pbp4p and associates with ribosomes  contains an RNA-binding LSM domain and an AD domain  GFP-fusion protein is induced by the DNA-damaging agent MMS
chrVIII	353624	354320	353624	354320	+	YHR122W	YHR122W		353624,	354320,	Protein of unknown function required for establishment of sister chromatid cohesion  synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment  YHR122W is an essential gene
chrVIII	354814	356081	354814	356081	+	EPT1	YHR123W		354814,354955,	354864,356081,	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase  not essential for viability
chrVIII	356560	358444	356560	358444	+	NDT80	YHR124W		356560,	358444,	Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination  activates middle sporulation genes  competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
chrVIII	358857	359163	358857	359163	+	YHR125W	YHR125W		358857,	359163,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	359701	360181	359701	360181	-	ANS1	YHR126C		359701,	360181,	Putative protein of unknown function  transcription dependent upon Azf1p
chrVIII	360912	361644	360912	361644	+	YHR127W	YHR127W		360912,	361644,	Protein of unknown function  localizes to the nucleus  required for asymmetric localization of Kar9p during mitosis
chrVIII	362114	362765	362114	362765	+	FUR1	YHR128W		362114,	362765,	Uracil phosphoribosyltransferase, synthesizes UMP from uracil  involved in the pyrimidine salvage pathway
chrVIII	362998	364153	362998	364153	-	ARP1	YHR129C		362998,	364153,	Actin-related protein of the dynactin complex  required for spindle orientation and nuclear migration  putative ortholog of mammalian centractin
chrVIII	364964	365300	364964	365300	-	YHR130C	YHR130C		364964,	365300,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	365339	367892	365339	367892	-	YHR131C	YHR131C		365339,	367892,	Putative protein of unknown function  GFP-fusion protein localizes to the cytoplasm  overexpression causes cell cycle delay or arrest  contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
chrVIII	367746	367992	367746	367992	+	YHR131W-A	YHR131W-A		367746,	367992,	Dubious open reading frame unlikely to encode a protein  partially overlaps the uncharacterized ORF YHR131C
chrVIII	368501	369794	368501	369794	-	ECM14	YHR132C		368501,	369794,	Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly
chrVIII	370053	370449	370053	370449	+	IGO2	YHR132W-A		370053,	370449,	Protein required for initiation of G0 program  prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway  phosphorylated by Rim15p  GFP protein localizes to the cytoplasm and nucleus  similar to Igo1p
chrVIII	370721	371597	370721	371597	-	NSG1	YHR133C		370721,	371597,	Protein involved in regulation of sterol biosynthesis  specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis  homolog of mammalian INSIG proteins
chrVIII	371748	372558	371748	372558	+	WSS1	YHR134W		371748,	372558,	Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters  interacts genetically with SMT3  UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
chrVIII	372693	374310	372693	374310	-	YCK1	YHR135C		372693,	374310,	Palmitoylated plasma membrane-bound casein kinase I isoform  shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking  provides an essential function overlapping with that of Yck2p
chrVIII	374653	375100	374653	375100	-	SPL2	YHR136C		374653,	375100,	Protein with similarity to cyclin-dependent kinase inhibitors  downregulates low-affinity phosphate transport during phosphate limitation  overproduction suppresses a plc1 null mutation  GFP-fusion protein localizes to the cytoplasm
chrVIII	375708	377250	375708	377250	+	ARO9	YHR137W		375708,	377250,	Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
chrVIII	375737	376388	375737	376388	-	YHR137C-A	YHR137C-A		375737,	376388,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps verified gene ARO9/YHR137W  identified by gene-trapping, expression analysis, and genome-wide homology searching
chrVIII	377354	377699	377354	377699	-	YHR138C	YHR138C		377354,	377699,	Putative protein of unknown function  has similarity to Pbi2p  double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
chrVIII	378218	379199	378218	379199	-	SPS100	YHR139C		378218,	379199,	Protein required for spore wall maturation  expressed during sporulation  may be a component of the spore wall  expression also induced in cells treated with the mycotoxin patulin
chrVIII	380107	380419	380107	380419	-	YHR139C-A	YHR139C-A		380107,	380419,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	380571	381291	380571	381291	+	YHR140W	YHR140W		380571,	381291,	Putative integral membrane protein of unknown function
chrVIII	381989	382751	381989	382751	-	RPL42B	YHR141C		381989,382747,	382306,382751,	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44  required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
chrVIII	383537	384488	383537	384488	+	CHS7	YHR142W		383537,	384488,	Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
chrVIII	385509	386487	385509	386487	+	DSE2	YHR143W		385509,	386487,	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother  expression is repressed by cAMP
chrVIII	387232	387445	387232	387445	+	RPC10	YHR143W-A		387232,	387445,	RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III
chrVIII	387787	388726	387787	388726	-	DCD1	YHR144C		387787,	388726,	Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis  expression is NOT cell cycle regulated
chrVIII	388980	389337	388980	389337	-	YHR145C	YHR145C		388980,	389337,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	390299	391697	390299	391697	+	CRP1	YHR146W		390299,	391697,	Protein that binds to cruciform DNA structures
chrVIII	392638	393283	392638	393283	-	MRPL6	YHR147C		392638,	393283,	Mitochondrial ribosomal protein of the large subunit
chrVIII	393533	394085	393533	394085	+	IMP3	YHR148W		393533,	394085,	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
chrVIII	394454	396659	394454	396659	-	SKG6	YHR149C		394454,	396659,	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery  potential Cdc28p substrate  Skg6p interacts with Zds1p and Zds2p
chrVIII	397250	398990	397250	398990	+	PEX28	YHR150W		397250,	398990,	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution  genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
chrVIII	399267	400848	399267	400848	-	MTC6	YHR151C		399267,	400848,	Protein of unknown function  mtc6 is synthetically sick with cdc13-1
chrVIII	401433	401955	401433	401955	+	SPO12	YHR152W		401433,	401955,	Nucleolar protein of unknown function, positive regulator of mitotic exit  involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
chrVIII	402085	402682	402085	402682	-	SPO16	YHR153C		402085,	402682,	Meiosis-specific protein involved in synaptonemal complex assembly  implicated in regulation of crossover formation  required for sporulation
chrVIII	402965	406178	402965	406178	+	RTT107	YHR154W		402965,	406178,	Protein implicated in Mms22-dependent DNA repair during S phase  involved in recruiting the SMC5/6 complex to double-strand breaks  DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs  interacts with Mms22p and Slx4p  has four BRCT domains  has a role in regulation of Ty1 transposition
chrVIII	407102	410789	407102	410789	+	YSP1	YHR155W		407102,	410789,	Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone
chrVIII	411383	412406	411383	412406	-	LIN1	YHR156C		411383,	412406,	Non-essential component of U5 snRNP  nuclear protein  physically interacts with Irr1p of cohesin complex  may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
chrVIII	412906	413455	412906	413455	+	REC104	YHR157W		412906,	413455,	Protein involved in early stages of meiotic recombination  required for meiotic crossing over  forms a complex with Rec102p and Spo11p necessary during the initiation of recombination
chrVIII	413684	417179	413684	417179	-	KEL1	YHR158C		413684,	417179,	Protein required for proper cell fusion and cell morphology  functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p  localizes to regions of polarized growth  potential Cdc28p substrate
chrVIII	417548	419063	417548	419063	+	YHR159W	YHR159W		417548,	419063,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  potential Cdc28p substrate  null mutant is sensitive to expression of the top1-T722A allele
chrVIII	419220	420072	419220	420072	-	PEX18	YHR160C		419220,	420072,	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2  interacts with Pex7p  partially redundant with Pex21p
chrVIII	420372	422286	420372	422286	-	YAP1801	YHR161C		420372,	422286,	Protein involved in clathrin cage assembly  binds Pan1p and clathrin  homologous to Yap1802p, member of the AP180 protein family
chrVIII	423071	423461	423071	423461	+	YHR162W	YHR162W		423071,	423461,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
chrVIII	423723	424473	423723	424473	+	SOL3	YHR163W		423723,	424473,	6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway  weak multicopy suppressor of los1-1 mutation  homologous to Sol2p and Sol1p
chrVIII	424609	429178	424609	429178	-	DNA2	YHR164C		424609,	429178,	Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities  required for Okazaki fragment processing  involved in DNA repair  cell-cycle dependent localization
chrVIII	429706	436948	429706	436948	-	PRP8	YHR165C		429706,	436948,	Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing  mutations of human Prp8 cause retinitis pigmentosa
chrVIII	436646	436958	436646	436958	+	YHR165W-A	YHR165W-A		436646,	436958,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	437169	439050	437169	439050	-	CDC23	YHR166C		437169,	439050,	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
chrVIII	439341	440127	439341	440127	+	THP2	YHR167W		439341,	440127,	Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export  involved in telomere maintenance
chrVIII	440376	441933	440376	441933	+	MTG2	YHR168W		440376,	441933,	Putative GTPase, member of the Obg family  peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit  required for mitochondrial translation, possibly via a role in ribosome assembly
chrVIII	442180	443476	442180	443476	+	DBP8	YHR169W		442180,	443476,	ATPase, putative RNA helicase of the DEAD-box family  component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit  ATPase activity stimulated by association with Esf2p
chrVIII	443827	445384	443827	445384	+	NMD3	YHR170W		443827,	445384,	Protein involved in nuclear export of the large ribosomal subunit  acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
chrVIII	445712	447605	445712	447605	+	ATG7	YHR171W		445712,	447605,	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes  mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
chrVIII	448334	450806	448334	450806	+	SPC97	YHR172W		448334,	450806,	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex  interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
chrVIII	450814	451153	450814	451153	-	YHR173C	YHR173C		450814,	451153,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	451326	452640	451326	452640	+	ENO2	YHR174W		451326,	452640,	Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis  expression is induced in response to glucose
chrVIII	452871	453441	452871	453441	+	CTR2	YHR175W		452871,	453441,	Putative low-affinity copper transporter of the vacuolar membrane  mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation
chrVIII	453557	453707	453557	453707	+	YHR175W-A	YHR175W-A		453557,	453707,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrVIII	454228	455527	454228	455527	+	FMO1	YHR176W		454228,	455527,	Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane  catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
chrVIII	456590	457952	456590	457952	+	YHR177W	YHR177W		456590,	457952,	Putative protein of unknown function  overexpression causes a cell cycle delay or arrest
chrVIII	459298	461530	459298	461530	+	STB5	YHR178W		459298,	461530,	Transcription factor, involved in regulating multidrug resistance and oxidative stress response  forms a heterodimer with Pdr1p  contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
chrVIII	462501	463704	462501	463704	+	OYE2	YHR179W		462501,	463704,	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties  may be involved in sterol metabolism, oxidative stress response, and programmed cell death
chrVIII	465177	465669	465177	465669	+	YHR180W	YHR180W		465177,	465669,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrVIII	466931	467114	466931	467114	+	YHR180W-A	YHR180W-A		466931,	467114,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
chrVIII	466957	467062	466957	467062	-	YHR180C-B	YHR180C-B		466957,	467062,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the dubious ORF YHR180W-A
chrVIII	467227	467914	467227	467914	+	SVP26	YHR181W		467227,	467914,	Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport  may also function to promote retention of proteins in the early Golgi compartment
chrVIII	468218	470576	468218	470576	+	YHR182W	YHR182W		468218,	470576,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm
chrVIII	470938	471412	470938	471412	-	YHR182C-A	YHR182C-A		470938,	471412,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	470959	472429	470959	472429	+	GND1	YHR183W		470959,	472429,	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway  required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
chrVIII	472743	474459	472743	474459	+	SSP1	YHR184W		472743,	474459,	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation  transcription is induced midway through meiosis
chrVIII	474626	475340	474626	475340	-	PFS1	YHR185C		474626,	475340,	Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II  not required for meiotic recombination or meiotic chromosome segregation
chrVIII	475998	480672	475998	480672	-	KOG1	YHR186C		475998,	480672,	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p  contains four HEAT repeats and seven WD-40 repeats  may act as a scaffold protein to couple TOR and its effectors
chrVIII	480989	481919	480989	481919	+	IKI1	YHR187W		480989,	481919,	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA  iki1 mutations confer resistance to the K. lactis toxin zymocin
chrVIII	482004	483837	482004	483837	-	GPI16	YHR188C		482004,	483837,	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins  human PIG-Tp homolog
chrVIII	484027	484600	484027	484600	+	PTH1	YHR189W		484027,	484600,	One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases  dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium
chrVIII	484844	486179	484844	486179	+	ERG9	YHR190W		484844,	486179,	Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
chrVIII	486229	486631	486229	486631	-	CTF8	YHR191C		486229,	486631,	Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
chrVIII	486825	487662	486825	487662	+	YHR192W	YHR192W		486825,	487662,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
chrVIII	487711	488236	487711	488236	-	EGD2	YHR193C		487711,	488236,	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
chrVIII	488652	489027	488652	489027	-	YHR193C-A	YHR193C-A		488652,	489027,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps verified ORF MDM31
chrVIII	488656	490396	488656	490396	+	MDM31	YHR194W		488656,	490396,	Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance  interacts genetically with MMM1, MDM10, MDM12, and MDM34
chrVIII	490746	491712	490746	491712	+	NVJ1	YHR195W		490746,	491712,	Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
chrVIII	491930	493658	491930	493658	+	UTP9	YHR196W		491930,	493658,	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
chrVIII	493895	496187	493895	496187	+	RIX1	YHR197W		493895,	496187,	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA  Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
chrVIII	496314	497280	496314	497280	-	AIM18	YHR198C		496314,	497280,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  null mutant displays elevated frequency of mitochondrial genome loss
chrVIII	497489	498422	497489	498422	-	AIM46	YHR199C		497489,	498422,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  null mutant displays elevated frequency of mitochondrial genome loss
chrVIII	498570	498859	498570	498859	-	NBL1	YHR199C-A		498570,498786,	498719,498859,	Subunit of the conserved chromosomal passenger complex (CPC  Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates mitotic chromosome segregation  not required for the kinase activity of the complex  mediates the interaction of Sli15p and Bir1p
chrVIII	499078	499885	499078	499885	+	RPN10	YHR200W		499078,	499885,	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome  N-terminus plays a role in maintaining the structural integrity of the RP  binds selectively to polyubiquitin chains  homolog of the mammalian S5a protein
chrVIII	499949	501143	499949	501143	-	PPX1	YHR201C		499949,	501143,	Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues  located in the cytosol, plasma membrane, and mitochondrial matrix
chrVIII	502387	504196	502387	504196	+	YHR202W	YHR202W		502387,	504196,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
chrVIII	504475	505530	504475	505530	-	RPS4B	YHR203C		504475,505516,	505247,505530,	Protein component of the small (40S) ribosomal subunit  identical to Rps4Ap and has similarity to rat S4 ribosomal protein
chrVIII	506318	508709	506318	508709	+	MNL1	YHR204W		506318,	508709,	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum  in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
chrVIII	509362	511837	509362	511837	+	SCH9	YHR205W		509362,	511837,	Protein kinase involved in transcriptional activation of osmostress-responsive genes  regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway  involved in life span regulation  homologous to mammalian Akt/PKB
chrVIII	512731	514600	512731	514600	+	SKN7	YHR206W		512731,	514600,	Nuclear response regulator and transcription factor  physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets  part of a branched two-component signaling system  required for optimal induction of heat-shock genes in response to oxidative stress  involved in osmoregulation
chrVIII	514904	516485	514904	516485	-	SET5	YHR207C		514904,	516485,	Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements  deletion enhances replication of positive-strand RNA virus
chrVIII	517531	518713	517531	518713	+	BAT1	YHR208W		517531,	518713,	Mitochondrial branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA biosynthesis  homolog of murine ECA39  highly expressed during logarithmic phase and repressed during stationary phase
chrVIII	519436	520312	519436	520312	+	CRG1	YHR209W		519436,	520312,	mRNA binding protein and putative S-adenosylmethionine-dependent methyltransferase  mediates cantharidin resistance
chrVIII	520711	521737	520711	521737	-	YHR210C	YHR210C		520711,	521737,	Putative protein of unknown function  non-essential gene  highly expressed under anaeorbic conditions  sequence similarity to aldose 1-epimerases such as GAL10
chrVIII	525391	528619	525391	528619	+	FLO5	YHR211W		525391,	528619,	Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile  similar to Flo1p
chrVIII	537758	538094	537758	538094	-	YHR212C	YHR212C		537758,	538094,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	538741	538945	538741	538945	+	YHR212W-A	YHR212W-A		538741,	538945,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVIII	539150	539747	539150	539747	+	YHR213W	YHR213W		539150,	539747,	Possible pseudogene  has similarity to Flo1p, which is a lectin-like protein involved in flocculation
chrVIII	540548	540782	540548	540782	+	YHR213W-A	YHR213W-A		540548,	540782,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVIII	540799	541099	540799	541099	+	YHR213W-B	YHR213W-B		540799,	541099,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVIII	541650	542262	541650	542262	+	YHR214W	YHR214W		541650,	542262,	Putative protein of unknown function  predicted to be a glycosylphosphatidylinositol-modified (GPI) protein
chrVIII	543007	543493	543007	543493	+	YHR214W-A	YHR214W-A		543007,	543493,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  similar to the fungal specific protein encoded by YAR068W  induced by zinc deficiency
chrVIII	543963	549346	543963	549346	-	YHR214C-B	YHR214C-B		543963,547930,	547929,549346,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrVIII	547909	549346	547909	549346	-	YHR214C-C	YHR214C-C		547909,	549346,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrVIII	550647	550941	550647	550941	-	YHR214C-D	YHR214C-D		550647,	550941,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVIII	551199	551499	551199	551499	-	YHR214C-E	YHR214C-E		551199,	551499,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrVIII	552098	553502	552098	553502	+	PHO12	YHR215W		552098,	553502,	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway  nearly identical to Pho11p  upregulated by phosphate starvation
chrVIII	554395	555967	554395	555967	+	IMD2	YHR216W		554395,	555967,	Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio
chrVIII	556580	557042	556580	557042	-	YHR217C	YHR217C		556580,	557042,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  located in the telomeric region TEL08R.
chrVIII	558013	559924	558013	559924	+	YHR218W	YHR218W		558013,558714,	558615,559924,	Helicase-like protein encoded within the telomeric Y' element
chrVIII	559931	560249	559931	560249	+	YHR218W-A	YHR218W-A		559931,	560249,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrVIII	560172	562047	560172	562047	+	YHR219W	YHR219W		560172,	562047,	Putative protein of unknown function with similarity to helicases  located in the telomere region on the right arm of chromosome VIII
chrVIII	561198	561681	561198	561681	-	YHR219C-A	YHR219C-A		561198,	561681,	Dubious open reading frame unlikely to encode a functional protein  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrX	465	6130	465	6130	-	YJL225C	YJL225C		465,4969,	4581,6130,	Putative protein of unknown function  similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors
chrX	828	1311	828	1311	+	YJL225W-A	YJL225W-A		828,	1311,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the uncharacterized gene YJL225C
chrX	8775	9138	8775	9138	-	PAU1	YJL223C		8775,	9138,	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme  identical to Pau14p
chrX	9345	9483	9345	9483	+	YJL222W-B	YJL222W-B		9345,	9483,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrX	9451	9679	9451	9679	+	YJL222W-A	YJL222W-A		9451,	9679,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrX	11474	16124	11474	16124	+	VTH2	YJL222W		11474,	16124,	Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
chrX	16766	18536	16766	18536	-	IMA4	YJL221C		16766,	18536,	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides  member of IMA isomaltase family  not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose
chrX	18242	18695	18242	18695	+	YJL220W	YJL220W		18242,	18695,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YJL221C/FSP2
chrX	19496	21200	19496	21200	+	HXT9	YJL219W		19496,	21200,	Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
chrX	21972	22563	21972	22563	+	YJL218W	YJL218W		21972,	22563,	Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases  induced by oleate in an OAF1/PIP2-dependent manner  promoter contains an oleate response element consensus sequence  non-essential gene
chrX	23132	23729	23132	23729	+	REE1	YJL217W		23132,	23729,	Cytoplasmic protein involved in the regulation of enolase (ENO1)  mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p)  mRNA expression is also regulated by the cell cycle
chrX	24340	26086	24340	26086	-	IMA5	YJL216C		24340,	26086,	Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose  member of the IMA isomaltase family  not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose
chrX	26411	26771	26411	26771	-	YJL215C	YJL215C		26411,	26771,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrX	26886	28596	26886	28596	+	HXT8	YJL214W		26886,	28596,	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
chrX	32162	33158	32162	33158	+	YJL213W	YJL213W		32162,	33158,	Protein of unknown function that may interact with ribosomes  periodically expressed during the yeast metabolic cycle  phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
chrX	33849	36249	33849	36249	-	OPT1	YJL212C		33849,	36249,	Proton-coupled oligopeptide transporter of the plasma membrane  also transports glutathione and phytochelatin  member of the OPT family
chrX	36756	37200	36756	37200	-	YJL211C	YJL211C		36756,	37200,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YJL210W/PEX2
chrX	36918	37734	36918	37734	+	PEX2	YJL210W		36918,	37734,	RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
chrX	38004	39969	38004	39969	+	CBP1	YJL209W		38004,	39969,	Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation  found in a complex at the inner membrane along with Pet309p
chrX	40193	41183	40193	41183	-	NUC1	YJL208C		40193,	41183,	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities  has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
chrX	41388	47433	41388	47433	-	LAA1	YJL207C		41388,	47433,	AP-1 accessory protein  colocalizes with clathrin to the late-Golgi apparatus  involved in TGN-endosome transport  physically interacts with AP-1  similar to the mammalian p200  may interact with ribosomes  YJL207C is a non-essential gene
chrX	47658	49935	47658	49935	-	YJL206C	YJL206C		47658,	49935,	Putative protein of unknown function  similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family  mRNA is weakly cell cycle regulated, peaking in S phase  induced rapidly upon MMS treatment
chrX	50138	50443	50138	50443	-	NCE101	YJL205C		50138,50411,	50268,50443,	Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
chrX	50628	53151	50628	53151	-	RCY1	YJL204C		50628,	53151,	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis  localized to sites of polarized growth
chrX	53340	54183	53340	54183	+	PRP21	YJL203W		53340,	54183,	Subunit of the SF3a splicing factor complex, required for spliceosome assembly
chrX	53942	54290	53942	54290	-	YJL202C	YJL202C		53942,	54290,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex
chrX	54378	56178	54378	56178	+	ECM25	YJL201W		54378,	56178,	Non-essential protein of unknown function  promoter contains a consensus binding sequence for factor Abf1p
chrX	56443	58813	56443	58813	-	ACO2	YJL200C		56443,	58813,	Putative mitochondrial aconitase isozyme  similarity to Aco1p, an aconitase required for the TCA cycle  expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
chrX	59855	60182	59855	60182	-	MBB1	YJL199C		59855,	60182,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  protein detected in large-scale protein-protein interaction studies
chrX	60843	63489	60843	63489	+	PHO90	YJL198W		60843,	63489,	Low-affinity phosphate transporter  deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality  transcription independent of Pi and Pho4p activity  overexpression results in vigorous growth
chrX	63804	67569	63804	67569	+	UBP12	YJL197W		63804,	67569,	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
chrX	65804	66086	65804	66086	-	YJL197C-A	YJL197C-A		65804,	66086,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene YJL197C/UBP12
chrX	67849	68782	67849	68782	-	ELO1	YJL196C		67849,	68782,	Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
chrX	69240	69942	69240	69942	-	YJL195C	YJL195C		69240,	69942,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YJL194W/CDC6
chrX	69337	70879	69337	70879	+	CDC6	YJL194W		69337,	70879,	Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association  homologous to S. pombe Cdc18p
chrX	71365	72574	71365	72574	+	YJL193W	YJL193W		71365,	72574,	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis  similar to YOR307C/SLY41  deletion mutant has a respiratory growth defect
chrX	72709	73414	72709	73414	-	SOP4	YJL192C		72709,	73414,	ER-membrane protein  suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
chrX	73786	74611	73786	74611	+	RPS14B	YJL191W		73786,74204,	73796,74611,	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing  mutations confer cryptopleurine resistance  nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins
chrX	74909	75302	74909	75302	-	RPS22A	YJL190C		74909,	75302,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
chrX	75932	76474	75932	76474	+	RPL39	YJL189W		75932,76324,	75938,76474,	Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein  required for ribosome biogenesis  loss of both Rpl31p and Rpl39p confers lethality  also exhibits genetic interactions with SIS1 and PAB1
chrX	76201	76510	76201	76510	-	BUD19	YJL188C		76201,	76510,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  88% of ORF overlaps the verified gene RPL39  diploid mutant displays a weak budding pattern phenotype in a systematic assay
chrX	76802	79262	76802	79262	-	SWE1	YJL187C		76802,	79262,	Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity  localizes to the nucleus and to the daughter side of the mother-bud neck  homolog of S. pombe Wee1p  potential Cdc28p substrate
chrX	80154	81915	80154	81915	+	MNN5	YJL186W		80154,	81915,	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
chrX	82094	82976	82094	82976	-	YJL185C	YJL185C		82094,	82976,	Putative protein of unknown function  mRNA is weakly cell cycle regulated, peaking in G2 phase  YJL185C is a non-essential gene
chrX	83447	83819	83447	83819	+	GON7	YJL184W		83447,	83819,	Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p  EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription  implicated in osmotic stress response
chrX	84067	85336	84067	85336	+	MNN11	YJL183W		84067,	85336,	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone  has homology to Mnn10p
chrX	85434	85752	85434	85752	-	YJL182C	YJL182C		85434,	85752,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps uncharacterized ORF YJL181W
chrX	85659	87495	85659	87495	+	YJL181W	YJL181W		85659,	87495,	Putative protein of unknown function  expression is cell-cycle regulated as shown by microarray analysis  potential regulatory target of Mbp1p, which binds to the YJL181W promoter region
chrX	87582	88560	87582	88560	-	ATP12	YJL180C		87582,	88560,	Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase  mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
chrX	88786	89116	88786	89116	+	PFD1	YJL179W		88786,	89116,	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it  involved in the biogenesis of actin and of alpha- and gamma-tubulin
chrX	89281	90097	89281	90097	-	ATG27	YJL178C		89281,	90097,	Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway  may be involved in membrane delivery to the phagophore assembly site
chrX	90785	91657	90785	91657	+	RPL17B	YJL177W		90785,91411,	91094,91657,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
chrX	92052	94530	92052	94530	-	SWI3	YJL176C		92052,	94530,	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes  required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
chrX	94048	94561	94048	94561	+	YJL175W	YJL175W		94048,	94561,	Dubious open reading frame unlikely to encode a functional protein  deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium  overlaps gene for SWI3 transcription factor
chrX	95091	95922	95091	95922	+	KRE9	YJL174W		95091,	95922,	Glycoprotein involved in cell wall beta-glucan assembly  null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
chrX	96160	96529	96160	96529	-	RFA3	YJL173C		96160,	96529,	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
chrX	97736	99467	97736	99467	+	CPS1	YJL172W		97736,	99467,	Vacuolar carboxypeptidase yscS  expression is induced under low-nitrogen conditions
chrX	99703	100894	99703	100894	-	YJL171C	YJL171C		99703,	100894,	GPI-anchored cell wall protein of unknown function  induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis  sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
chrX	101149	101779	101149	101779	-	ASG7	YJL170C		101149,	101779,	Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell  specific to a-cells and induced by alpha-factor
chrX	102098	102467	102098	102467	+	YJL169W	YJL169W		102098,	102467,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YJL168C/SET2
chrX	102226	104428	102226	104428	-	SET2	YJL168C		102226,	104428,	Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3  associates with the C-terminal domain of Rpo21p  histone methylation activity is regulated by phosphorylation status of Rpo21p
chrX	105013	106072	105013	106072	+	ERG20	YJL167W		105013,	106072,	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities  catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
chrX	106433	106718	106433	106718	+	QCR8	YJL166W		106433,	106718,	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain  oriented facing the intermembrane space  expression is regulated by Abf1p and Cpf1p
chrX	106893	109461	106893	109461	-	HAL5	YJL165C		106893,	109461,	Putative protein kinase  overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters
chrX	109965	111159	109965	111159	-	TPK1	YJL164C		109965,	111159,	cAMP-dependent protein kinase catalytic subunit  promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway  inhibited by regulatory subunit Bcy1p in the absence of cAMP  partially redundant with Tpk2p and Tpk3p
chrX	111665	113333	111665	113333	-	YJL163C	YJL163C		111665,	113333,	Putative protein of unknown function
chrX	113877	115629	113877	115629	-	JJJ2	YJL162C		113877,	115629,	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
chrX	117244	117787	117244	117787	+	FMP33	YJL161W		117244,	117787,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrX	117961	118825	117961	118825	-	YJL160C	YJL160C		117961,	118825,	Putative protein of unknown function  member of the PIR (proteins with internal repeats) family of cell wall proteins  non-essential gene that is required for sporulation  mRNA is weakly cell cycle regulated, peaking in mitosis
chrX	120448	121690	120448	121690	+	HSP150	YJL159W		120448,	121690,	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges  required for cell wall stability  induced by heat shock, oxidative stress, and nitrogen limitation
chrX	122264	122948	122264	122948	-	CIS3	YJL158C		122264,	122948,	Mannose-containing glycoprotein constituent of the cell wall  member of the PIR (proteins with internal repeats) family
chrX	123835	126328	123835	126328	-	FAR1	YJL157C		123835,	126328,	Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone  also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating  potential Cdc28p substrate
chrX	126603	126825	126603	126825	+	YJL156W-A	YJL156W-A		126603,	126825,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrX	126852	128952	126852	128952	-	SSY5	YJL156C		126852,	128952,	Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)  contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p
chrX	129284	130643	129284	130643	-	FBP26	YJL155C		129284,	130643,	Fructose-2,6-bisphosphatase, required for glucose metabolism
chrX	131100	133935	131100	133935	-	VPS35	YJL154C		131100,	133935,	Endosomal subunit of membrane-associated retromer complex required for retrograde transport  receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval
chrX	134331	135933	134331	135933	-	INO1	YJL153C		134331,	135933,	Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids  transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
chrX	136173	136533	136173	136533	+	YJL152W	YJL152W		136173,	136533,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	136371	136773	136371	136773	-	SNA3	YJL151C		136371,	136773,	Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
chrX	137122	137425	137122	137425	+	YJL150W	YJL150W		137122,	137425,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	137378	139370	137378	139370	+	DAS1	YJL149W		137378,	139370,	Putative SCF ubiquitin ligase F-box protein  interacts physically with both Cdc53p and Skp1 and genetically with CDC34  similar to putative F-box protein YDR131C
chrX	140436	141138	140436	141138	+	RPA34	YJL148W		140436,	141138,	RNA polymerase I subunit A34.5
chrX	141418	142567	141418	142567	-	YJL147C	YJL147C		141418,	142567,	Mitochondrial protein of unknown function  homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction  expression induced by calcium shortage  YJL147W is a non-essential gene
chrX	143291	144701	143291	144701	+	IDS2	YJL146W		143291,	144701,	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions  found in growing cells and degraded during sporulation
chrX	145159	146044	145159	146044	+	SFH5	YJL145W		145159,	146044,	Non-classical phosphatidylinositol transfer protein (PITP)  exhibits PI- but not PC-transfer activity  localizes to the peripheral endoplasmic reticulum, cytosol and microsomes  similar to Sec14p
chrX	146358	146673	146358	146673	+	YJL144W	YJL144W		146358,	146673,	Cytoplasmic hydrophilin with a role in dessication resistance  expression induced by osmotic stress, starvation and during stationary phase  GFP-fusion protein is induced by the DNA-damaging agent MMS
chrX	147100	147577	147100	147577	+	TIM17	YJL143W		147100,	147577,	Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  with Tim23p, contributes to the architecture and function of the import channel  may link the import motor to the core TIM23 complex
chrX	147818	148211	147818	148211	-	IRC9	YJL142C		147818,	148211,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene YJL141C  null mutant displays increased levels of spontaneous Rad52p foci
chrX	147966	150390	147966	150390	-	YAK1	YJL141C		147966,	150390,	Serine-threonine protein kinase  component of a glucose-sensing system that inhibits growth in response to glucose availability  upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p  nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
chrX	150960	151626	150960	151626	+	RPB4	YJL140W		150960,	151626,	RNA polymerase II subunit B32  forms two subunit dissociable complex with Rpb7p  involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions  also involved in translation initiation
chrX	151712	152999	151712	152999	-	YUR1	YJL139C		151712,	152999,	Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation  located in the Golgi apparatus
chrX	153503	154691	153503	154691	-	TIF2	YJL138C		153503,	154691,	Translation initiation factor eIF4A, identical to Tif1p  DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding  forms a dumbbell structure of two compact domains connected by a linker  interacts with eIF4G
chrX	154984	156127	154984	156127	-	GLG2	YJL137C		154984,	156127,	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside  similar to mammalian glycogenin
chrX	156168	156252	156168	156252	+	YJL136W-A	YJL136W-A		156168,	156252,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified by SAGE
chrX	156549	157273	156549	157273	-	RPS21B	YJL136C		156549,157249,	156789,157273,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
chrX	157876	158194	157876	158194	+	YJL135W	YJL135W		157876,	158194,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified genes YJL134W/LCB3
chrX	158187	159417	158187	159417	+	LCB3	YJL134W		158187,	159417,	Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids
chrX	159622	159847	159622	159847	-	YJL133C-A	YJL133C-A		159622,	159847,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrX	160618	161563	160618	161563	+	MRS3	YJL133W		160618,	161563,	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane  mitochondrial carrier family member, similar to and functionally redundant with Mrs4p  active under low-iron conditions  may transport other cations
chrX	161913	164166	161913	164166	+	YJL132W	YJL132W		161913,	164166,	Putative protein of unknown function  localizes to the membrane fraction  possible Zap1p-regulated target gene induced by zinc deficiency  YJL132W is a non-essential gene
chrX	164277	165348	164277	165348	-	AIM23	YJL131C		164277,	165348,	Putative protein of unknown function  the authentic non-tagged protein is detected in highly purified mitochondria  null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
chrX	165722	172367	165722	172367	-	URA2	YJL130C		165722,	172367,	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines  both activities are subject to feedback inhibition by UTP
chrX	173598	177306	173598	177306	-	TRK1	YJL129C		173598,	177306,	Component of the Trk1p-Trk2p potassium transport system  180 kDa high affinity potassium transporter  phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
chrX	178096	180103	178096	180103	-	PBS2	YJL128C		178096,	180103,	MAP kinase kinase of the HOG signaling pathway  activated under severe osmotic stress  mitophagy-specific regulator  plays a role in regulating Ty1 transposition
chrX	180193	180310	180193	180310	+	YJL127W-A	YJL127W-A		180193,	180310,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrX	181550	181709	181550	181709	-	YJL127C-B	YJL127C-B		181550,	181709,	Putative protein of unknown function  identified based on homology to the filamentous fungus, Ashbya gossypii
chrX	182297	184220	182297	184220	-	SPT10	YJL127C		182297,	184220,	Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
chrX	184500	185424	184500	185424	+	NIT2	YJL126W		184500,	185424,	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor  nitrilase superfamily member
chrX	185527	186679	185527	186679	-	GCD14	YJL125C		185527,	186679,	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met  first identified as a negative regulator of GCN4 expression
chrX	187125	187644	187125	187644	-	LSM1	YJL124C		187125,	187644,	Lsm (Like Sm) protein  forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
chrX	188003	189440	188003	189440	-	MTC1	YJL123C		188003,	189440,	Protein of unknown function that may interact with ribosomes  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi)  mtc1 is synthetically lethal with cdc13-1
chrX	189715	190243	189715	190243	+	ALB1	YJL122W		189715,	190243,	Shuttling pre-60S factor  involved in the biogenesis of ribosomal large subunit  interacts directly with Arx1p  responsible for Tif6p recycling defects in absence of Rei1p
chrX	190373	191090	190373	191090	-	RPE1	YJL121C		190373,	191090,	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway  mutants are sensitive to oxidative stress
chrX	191021	191345	191021	191345	+	YJL120W	YJL120W		191021,	191345,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YJL121C/RPE1  deletion confers sensitivity to GSAO
chrX	191571	191895	191571	191895	-	YJL119C	YJL119C		191571,	191895,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	191638	192298	191638	192298	+	YJL118W	YJL118W		191638,	192298,	Putative protein of unknown function  may interact with ribosomes, based on co-purification experiments  YJL18W is a non-essential gene  deletion enhances the toxicity of heterologously expressed human alpha-synuclein
chrX	192530	193466	192530	193466	+	PHO86	YJL117W		192530,	193466,	Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
chrX	193859	194873	193859	194873	-	NCA3	YJL116C		193859,	194873,	Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase  member of the SUN family  expression induced in cells treated with the mycotoxin patulin
chrX	196286	197126	196286	197126	+	ASF1	YJL115W		196286,	197126,	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed  plays a role in regulating Ty1 transposition
chrX	197914	198595	197914	198595	+	YJL114W	YJL114W		197914,	198595,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrX	198677	203325	198677	203325	+	YJL113W	YJL113W		198677,198999,	198998,203325,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrX	205304	207449	205304	207449	+	MDV1	YJL112W		205304,	207449,	Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission  interacts with Fis1p and with the dynamin-related GTPase Dnm1p  contains WD repeats
chrX	207876	209529	207876	209529	+	CCT7	YJL111W		207876,	209529,	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo  mutant has increased aneuploidy tolerance
chrX	209921	211577	209921	211577	-	GZF3	YJL110C		209921,	211577,	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding  function requires a repressive carbon source  dimerizes with Dal80p and binds to Tor1p
chrX	211999	217309	211999	217309	-	UTP10	YJL109C		211999,	217309,	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA  mutant has increased aneuploidy tolerance
chrX	217704	218856	217704	218856	-	PRM10	YJL108C		217704,	218856,	Pheromone-regulated protein, proposed to be involved in mating  predicted to have 5 transmembrane segments  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrX	218852	220016	218852	220016	-	YJL107C	YJL107C		218852,	220016,	Putative protein of unknown function  expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent  YJL107C and adjacent ORF, YJL108C are merged in related fungi
chrX	221389	223327	221389	223327	+	IME2	YJL106W		221389,	223327,	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p  IME2 expression is positively regulated by Ime1p
chrX	225054	226737	225054	226737	+	SET4	YJL105W		225054,	226737,	Protein of unknown function, contains a SET domain
chrX	227326	227776	227326	227776	+	PAM16	YJL104W		227326,	227776,	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity  contains a J-like domain
chrX	229024	230881	229024	230881	-	GSM1	YJL103C		229024,	230881,	Putative zinc cluster protein of unknown function  proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
chrX	231300	233760	231300	233760	+	MEF2	YJL102W		231300,	233760,	Mitochondrial elongation factor involved in translational elongation
chrX	234319	236356	234319	236356	-	GSH1	YJL101C		234319,	236356,	Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis  expression induced by oxidants, cadmium, and mercury
chrX	237262	239086	237262	239086	+	LSB6	YJL100W		237262,	239086,	Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
chrX	239413	241654	239413	241654	+	CHS6	YJL099W		239413,	241654,	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
chrX	242081	245258	242081	245258	+	SAP185	YJL098W		242081,	245258,	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function  member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
chrX	245590	246244	245590	246244	+	PHS1	YJL097W		245590,	246244,	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids  evolutionarily conserved, similar to mammalian PTPLA and PTPLB  involved in sphingolipid biosynthesis and protein trafficking
chrX	246489	246975	246489	246975	+	MRPL49	YJL096W		246489,	246975,	Mitochondrial ribosomal protein of the large subunit
chrX	247254	251691	247254	251691	+	BCK1	YJL095W		247254,	251691,	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity  upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
chrX	251820	254442	251820	254442	-	KHA1	YJL094C		251820,	254442,	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
chrX	254736	256812	254736	256812	-	TOK1	YJL093C		254736,	256812,	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium  carboxy tail functions to prevent inner gate closures  target of K1 toxin
chrX	257422	260947	257422	260947	+	SRS2	YJL092W		257422,	260947,	DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II  blocks trinucleotide repeat expansion  affects genome stability
chrX	261079	262552	261079	262552	-	GWT1	YJL091C		261079,	262552,	Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
chrX	262756	265051	262756	265051	-	DPB11	YJL090C		262756,	265051,	Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins  checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p  ortholog of human TopBP1
chrX	265925	268415	265925	268415	+	SIP4	YJL089W		265925,	268415,	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes  involved in the positive regulation of gluconeogenesis  regulated by Snf1p protein kinase  localized to the nucleus
chrX	268798	269815	268798	269815	+	ARG3	YJL088W		268798,	269815,	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
chrX	270001	272485	270001	272485	-	TRL1	YJL087C		270001,	272485,	tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR  has phosphodiesterase, polynucleotide kinase, and ligase activities  localized at the inner nuclear envelope and partially to polysomes
chrX	272477	272846	272477	272846	-	YJL086C	YJL086C		272477,	272846,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
chrX	272826	274698	272826	274698	+	EXO70	YJL085W		272826,	274698,	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis  acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding
chrX	274861	278002	274861	278002	-	ALY2	YJL084C		274861,	278002,	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p  interacts with AP-1 subunit Apl4p  phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p  promotes endocytosis of plasma membrane proteins
chrX	278840	280655	278840	280655	+	TAX4	YJL083W		278840,	280655,	EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy  Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p  Irs4p and Tax4p are involved in localizing Atg17p to the PAS
chrX	281184	283380	281184	283380	+	IML2	YJL082W		281184,	283380,	Protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrX	283801	285271	283801	285271	-	ARP4	YJL081C		283801,	285271,	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
chrX	285557	289226	285557	289226	-	SCP160	YJL080C		285557,	289226,	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
chrX	289874	290774	289874	290774	-	PRY1	YJL079C		289874,	290774,	Protein of unknown function
chrX	291335	293981	291335	293981	-	PRY3	YJL078C		291335,	293981,	Cell wall protein with a role in mating efficiency  expression of full-length transcript is daughter cell-specific  in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
chrX	294046	294145	294046	294145	+	YJL077W-B	YJL077W-B		294046,	294145,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrX	294665	295061	294665	295061	-	ICS3	YJL077C		294665,	295061,	Protein of unknown function  may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2
chrX	294798	294885	294798	294885	+	YJL077W-A	YJL077W-A		294798,	294885,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene YJL077C/ICS3
chrX	295244	298814	295244	298814	+	NET1	YJL076W		295244,	298814,	Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit  stimulates transcription by RNA polymerase I and regulates nucleolar structure
chrX	298459	298876	298459	298876	-	APQ13	YJL075C		298459,	298876,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  85% of ORF overlaps the verified gene NET1  null mutant is sensitive to sorbate
chrX	299156	302849	299156	302849	-	SMC3	YJL074C		299156,	302849,	Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells  also required, with Rec8p, for cohesion and recombination during meiosis  phylogenetically conserved SMC chromosomal ATPase family member
chrX	303180	305118	303180	305118	+	JEM1	YJL073W		303180,	305118,	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane  exhibits genetic interactions with KAR2
chrX	305220	305862	305220	305862	-	PSF2	YJL072C		305220,	305862,	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
chrX	306131	307856	306131	307856	+	ARG2	YJL071W		306131,	307856,	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine  forms a complex with Arg5,6p
chrX	307970	310637	307970	310637	-	YJL070C	YJL070C		307970,	310637,	Putative protein of unknown function with similarity to AMP deaminases  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  YJL070C is a non-essential gene
chrX	310921	312706	310921	312706	-	UTP18	YJL069C		310921,	312706,	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
chrX	313015	313915	313015	313915	-	YJL068C	YJL068C		313015,	313915,	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase  may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione  similar to human esterase D
chrX	314083	314434	314083	314434	+	YJL067W	YJL067W		314083,	314434,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	314113	314872	314113	314872	-	MPM1	YJL066C		314113,	314872,	Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
chrX	315053	315557	315053	315557	-	DLS1	YJL065C		315053,	315557,	Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p  involved in inheritance of telomeric silencing
chrX	315174	315570	315174	315570	+	YJL064W	YJL064W		315174,	315570,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene YJL065C/DLS1
chrX	315758	316475	315758	316475	-	MRPL8	YJL063C		315758,	316475,	Mitochondrial ribosomal protein of the large subunit
chrX	316722	316980	316722	316980	+	COA3	YJL062W-A		316722,	316980,	Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
chrX	317283	319776	317283	319776	+	LAS21	YJL062W		317283,	319776,	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure  mutations affect cell wall integrity
chrX	320015	322157	320015	322157	+	NUP82	YJL061W		320015,	322157,	Nucleoporin, subunit of the nuclear pore complex (NPC)  forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC
chrX	323385	324720	323385	324720	+	BNA3	YJL060W		323385,	324720,	Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine  potential Cdc28p substrate
chrX	324963	326190	324963	326190	+	YHC3	YJL059W		324963,	326190,	Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis  homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
chrX	326241	327873	326241	327873	-	BIT61	YJL058C		326241,	327873,	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity
chrX	328117	330121	328117	330121	-	IKS1	YJL057C		328117,	330121,	Putative serine/threonine kinase  expression is induced during mild heat stress  deletion mutants are hypersensitive to copper sulphate and resistant to sorbate  interacts with an N-terminal fragment of Sst2p
chrX	330430	333073	330430	333073	-	ZAP1	YJL056C		330430,	333073,	Zinc-regulated transcription factor  binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc  regulates its own transcription  contains seven zinc-finger domains
chrX	333356	334094	333356	334094	+	YJL055W	YJL055W		333356,	334094,	Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues  deletion mutants are sensitive to HAP and AHA  overexpression confers resistance to 5-FOA and 5-FU
chrX	334264	335701	334264	335701	+	TIM54	YJL054W		334264,	335701,	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
chrX	335897	337037	335897	337037	+	PEP8	YJL053W		335897,	337037,	Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p  essential for endosome-to-Golgi retrograde protein transport
chrX	337883	338003	337883	338003	-	YJL052C-A	YJL052C-A		337883,	338003,	Putative protein of unknown function, identified based on comparison to related yeast species
chrX	338270	339269	338270	339269	+	TDH1	YJL052W		338270,	339269,	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis  tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate  detected in the cytoplasm and cell wall
chrX	339786	342255	339786	342255	+	IRC8	YJL051W		339786,	342255,	Bud tip localized protein of unknown function  mRNA is targeted to the bud by a She2p dependent transport system  mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase  null mutant displays increased levels of spontaneous Rad52p foc
chrX	342521	345743	342521	345743	+	MTR4	YJL050W		342521,	345743,	ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes  has a KOW domain that shows RNA binding activity
chrX	345972	347325	345972	347325	+	YJL049W	YJL049W		345972,	347325,	Putative protein of unknown function  YJL049W is a non-essential gene
chrX	347446	348637	347446	348637	-	UBX6	YJL048C		347446,	348637,	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
chrX	349043	349178	349043	349178	-	YJL047C-A	YJL047C-A		349043,	349178,	Putative protein of unknown function
chrX	349579	352108	349579	352108	-	RTT101	YJL047C		349579,	352108,	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression  implicated in Mms22-dependent DNA repair  involved with Mms1p in nonfunctional rRNA decay  modified by the ubiquitin-like protein, Rub1p
chrX	352385	353615	352385	353615	+	AIM22	YJL046W		352385,	353615,	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p  similar to E. coli LplA  null mutant displays reduced frequency of mitochondrial genome loss
chrX	356023	357928	356023	357928	+	YJL045W	YJL045W		356023,	357928,	Minor succinate dehydrogenase isozyme  homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone  induced during the diauxic shift in a Cat8p-dependent manner
chrX	358299	359676	358299	359676	-	GYP6	YJL044C		358299,	359676,	GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p  involved in vesicle mediated protein transport
chrX	360129	360903	360129	360903	+	YJL043W	YJL043W		360129,	360903,	Putative protein of unknown function  YJL043W is a non-essential gene
chrX	361248	365445	361248	365445	+	MHP1	YJL042W		361248,	365445,	Microtubule-associated protein involved in assembly and stabilization of microtubules  overproduction results in cell cycle arrest at G2 phase  similar to Drosophila protein MAP and to mammalian MAP4 proteins
chrX	365783	368373	365783	368373	+	NSP1	YJL041W		365783,365902,	365784,368373,	Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes
chrX	368747	373799	368747	373799	-	NUP192	YJL039C		368747,	373799,	Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
chrX	375114	375774	375114	375774	-	LOH1	YJL038C		375114,	375774,	Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly  induced during sporulation  repressed during vegetative growth by Sum1p and Hst1p  sequence similar to IRC1
chrX	376661	377336	376661	377336	+	IRC18	YJL037W		376661,	377336,	Putative protein of unknown function  expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures  similar to adjacent ORF, YJL038C  null mutant displays increased levels of spontaneous Rad52p foci
chrX	378824	380096	378824	380096	+	SNX4	YJL036W		378824,	380096,	Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport  contains a PX phosphoinositide-binding domain  forms complexes with Snx41p and with Atg20p
chrX	380248	381001	380248	381001	-	TAD2	YJL035C		380248,	381001,	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
chrX	381326	383375	381326	383375	+	KAR2	YJL034W		381326,	383375,	ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins  regulates the unfolded protein response via interaction with Ire1p
chrX	383836	386149	383836	386149	+	HCA4	YJL033W		383836,	386149,	Putative nucleolar DEAD box RNA helicase  high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
chrX	386347	386662	386347	386662	+	YJL032W	YJL032W		386347,	386662,	Dubious open reading frame unlikely to encode a functional protein  overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
chrX	386367	387438	386367	387438	-	BET4	YJL031C		386367,387435,	387348,387438,	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi  provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
chrX	387656	388247	387656	388247	+	MAD2	YJL030W		387656,	388247,	Component of the spindle-assembly checkpoint complex  delays the onset of anaphase in cells with defects in mitotic spindle assembly  forms a complex with Mad1p  regulates APC/C activity during prometaphase and metaphase of meiosis I
chrX	388384	390853	388384	390853	-	VPS53	YJL029C		388384,	390853,	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi  required for vacuolar protein sorting
chrX	391310	391646	391310	391646	+	YJL028W	YJL028W		391310,	391646,	Protein of unknown function  may interact with ribosomes, based on co-purification experiments
chrX	391832	392249	391832	392249	-	YJL027C	YJL027C		391832,	392249,	Putative protein of unknown function
chrX	392403	393603	392403	393603	+	RNR2	YJL026W		392403,	393603,	Ribonucleotide-diphosphate reductase (RNR), small subunit  the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
chrX	393065	393287	393065	393287	-	YJL026C-A	YJL026C-A		393065,	393287,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene YJL026W/RNR2
chrX	393966	395511	393966	395511	+	RRN7	YJL025W		393966,	395511,	Component of the core factor (CF) rDNA transcription factor complex  CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
chrX	395930	396592	395930	396592	-	APS3	YJL024C		395930,396570,	396493,396592,	Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting  related to the sigma subunit of the mammalian clathrin AP-3 complex  suppressor of loss of casein kinase 1 function
chrX	397354	398398	397354	398398	-	PET130	YJL023C		397354,	398398,	Protein required for respiratory growth  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrX	398108	398417	398108	398417	+	YJL022W	YJL022W		398108,	398417,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene PET130
chrX	398936	402410	398936	402410	-	BBC1	YJL020C		398936,	402410,	Protein possibly involved in assembly of actin patches  interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p  localized predominantly to cortical actin patches
chrX	400980	401238	400980	401238	+	YJL020W-A	YJL020W-A		400980,	401238,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene YJL020C/BBC1
chrX	402896	404945	402896	404945	+	MPS3	YJL019W		402896,	404945,	Nuclear envelope protein required for SPB duplication and nuclear fusion  localizes to the SPB half bridge and at telomeres during meiosis  required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement
chrX	405587	407273	405587	407273	+	YJL016W	YJL016W		405587,	407273,	Putative protein of unknown function  GFP-fusion protein localizes to the cytoplasm  conserved in closely related Saccharomyces species
chrX	407141	407426	407141	407426	-	YJL015C	YJL015C		407141,	407426,	Dubious open reading frame unlikely to encode a functional protein  expression if heat-inducible  located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
chrX	407557	409162	407557	409162	+	CCT3	YJL014W		407557,	409162,	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
chrX	409492	411040	409492	411040	-	MAD3	YJL013C		409492,	411040,	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly  pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
chrX	411233	413399	411233	413399	-	VTC4	YJL012C		411233,	413399,	Vacuolar membrane polyphosphate polymerase  subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole  regulates membrane trafficking  role in non-autophagic vacuolar fusion
chrX	414284	414770	414284	414770	-	RPC17	YJL011C		414284,	414770,	RNA polymerase III subunit C17  physically interacts with C31, C11, and TFIIIB70  may be involved in the recruitment of pol III by the preinitiation complex
chrX	417561	419562	417561	419562	-	NOP9	YJL010C		417561,	419562,	Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit  also part of pre-40S ribosome and required for its export into cytoplasm  binds RNA and contains pumilio domain
chrX	419854	420181	419854	420181	+	YJL009W	YJL009W		419854,	420181,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
chrX	419956	421663	419956	421663	-	CCT8	YJL008C		419956,	421663,	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
chrX	422697	423012	422697	423012	-	YJL007C	YJL007C		422697,	423012,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	423137	424109	423137	424109	-	CTK2	YJL006C		423137,	424109,	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity
chrX	425156	431237	425156	431237	+	CYR1	YJL005W		425156,	431237,	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling  the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
chrX	431588	432200	431588	432200	-	SYS1	YJL004C		431588,	432200,	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi  multicopy suppressor of ypt6 null mutation
chrX	432643	433000	432643	433000	+	COX16	YJL003W		432643,	433000,	Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase
chrX	433220	434651	433220	434651	-	OST1	YJL002C		433220,	434651,	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
chrX	435162	435926	435162	435926	+	PRE3	YJL001W		435162,435343,	435227,435926,	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
chrX	436801	438610	436801	438610	+	AVT1	YJR001W		436801,	438610,	Vacuolar transporter, imports large neutral amino acids into the vacuole  member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
chrX	438864	440646	438864	440646	+	MPP10	YJR002W		438864,	440646,	Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability  similar to human Mpp10p
chrX	440993	442553	440993	442553	-	YJR003C	YJR003C		440993,	442553,	Putative protein of unknown function  detected in highly purified mitochondria in high-throughput studies  predicted to be involved in ribosome biogenesis
chrX	442908	444861	442908	444861	-	SAG1	YJR004C		442908,	444861,	Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
chrX	445922	448025	445922	448025	+	APL1	YJR005W		445922,	448025,	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2)  involved in vesicle mediated transport  similar to mammalian beta-chain of the clathrin associated protein complex
chrX	448476	448758	448476	448758	-	YJR005C-A	YJR005C-A		448476,	448758,	Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene
chrX	449201	450665	449201	450665	+	POL31	YJR006W		449201,	450665,	DNA polymerase III (delta) subunit, essential for cell viability  involved in DNA replication and DNA repair
chrX	451019	451934	451019	451934	+	SUI2	YJR007W		451019,	451934,	Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon  phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
chrX	452429	453446	452429	453446	+	YJR008W	YJR008W		452429,	453446,	Putative protein of unknown function  expression repressed by inosine and choline in an Opi1p-dependent manner  expression induced by mild heat-stress on a non-fermentable carbon source.
chrX	453682	454681	453682	454681	-	TDH2	YJR009C		453682,	454681,	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis  tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate  detected in the cytoplasm and cell wall
chrX	456238	457774	456238	457774	+	MET3	YJR010W		456238,	457774,	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
chrX	458076	458361	458076	458361	-	SPC1	YJR010C-A		458076,	458361,	Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex
chrX	458640	459426	458640	459426	-	YJR011C	YJR011C		458640,	459426,	Putative protein of unknown function  GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
chrX	459794	460418	459794	460418	-	YJR012C	YJR012C		459794,	460418,	Essential protein of unknown function  proposed involvement in transport based on mass spectrometry analysis of copurifying proteins  partially overlaps neighboring ORF, GPI14/YJR013W
chrX	460381	461593	460381	461593	+	GPI14	YJR013W		460381,	461593,	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function  homolog of mammalian PIG-M
chrX	461828	462425	461828	462425	+	TMA22	YJR014W		461828,	462425,	Protein of unknown function  associates with ribosomes and has a putative RNA binding domain  interacts with Tma20p  similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1
chrX	462720	464253	462720	464253	+	YJR015W	YJR015W		462720,	464253,	Putative protein of unknown function  localizes to the endoplasmic reticulum and cytoplasm  predicted to encode a membrane transporter based on phylogenetic analysis  YJR015W is a non-essential gene
chrX	464450	466208	464450	466208	-	ILV3	YJR016C		464450,	466208,	Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
chrX	466520	467033	466520	467033	-	ESS1	YJR017C		466520,	467033,	Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline  regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
chrX	466785	467148	466785	467148	+	YJR018W	YJR018W		466785,	467148,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	467231	468281	467231	468281	-	TES1	YJR019C		467231,	468281,	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis  conserved protein also found in human peroxisomes  TES1 mRNA levels increase during growth on fatty acids
chrX	468000	468333	468000	468333	+	YJR020W	YJR020W		468000,	468333,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	468554	469579	468554	469579	-	REC107	YJR021C		468554,469263,	469183,469579,	Protein involved in early stages of meiotic recombination  involved in coordination between the initiation of recombination and the first division of meiosis  part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
chrX	469783	470113	469783	470113	+	LSM8	YJR022W		469783,	470113,	Lsm (Like Sm) protein  forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
chrX	469803	470205	469803	470205	-	YJR023C	YJR023C		469803,	470205,	Putative protein of unknown function  open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
chrX	470229	470964	470229	470964	-	MDE1	YJR024C		470229,	470964,	5'-methylthioribulose-1-phosphate dehydratase  acts in the methionine salvage pathway  potential Smt3p sumoylation substrate  expression downregulated by caspofungin and deletion mutant is caspofungin resistant
chrX	471137	471671	471137	471671	-	BNA1	YJR025C		471137,	471671,	3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine  expression regulated by Hst1p
chrX	472759	478028	472759	478028	+	YJR027W	YJR027W		472759,474062,	474061,478028,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrX	472759	474082	472759	474082	+	YJR026W	YJR026W		472759,	474082,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrX	478343	483612	478343	483612	+	YJR029W	YJR029W		478343,479645,	479644,483612,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrX	478343	479666	478343	479666	+	YJR028W	YJR028W		478343,	479666,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrX	483958	486196	483958	486196	-	YJR030C	YJR030C		483958,	486196,	Putative protein of unknown function  expression repressed in carbon limited vs carbon replete chemostat cultures  YJR030C is a non-essential gene
chrX	486585	490812	486585	490812	-	GEA1	YJR031C		486585,	490812,	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization  similar to but not functionally redundant with Gea2p
chrX	491080	492262	491080	492262	+	CPR7	YJR032W		491080,	492262,	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  binds to Hsp82p and contributes to chaperone activity
chrX	492377	496451	492377	496451	-	RAV1	YJR033C		492377,	496451,	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme  required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins  potential Cdc28p substrate
chrX	496682	497009	496682	497009	+	PET191	YJR034W		496682,	497009,	Protein required for assembly of cytochrome c oxidase  exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space  contains a twin Cx9C motif
chrX	497354	500612	497354	500612	+	RAD26	YJR035W		497354,	500612,	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions  recruitment to DNA lesions is dependent on an elongating RNA polymerase II  homolog of human CSB protein
chrX	500712	503391	500712	503391	-	HUL4	YJR036C		500712,	503391,	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
chrX	503101	503485	503101	503485	+	YJR037W	YJR037W		503101,	503485,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene HUL4/YJR036C  deletion mutant has decreased spore survival in Drosophila feces
chrX	503709	504072	503709	504072	-	YJR038C	YJR038C		503709,	504072,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	503935	507301	503935	507301	+	YJR039W	YJR039W		503935,	507301,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrX	507745	510085	507745	510085	+	GEF1	YJR040W		507745,	510085,	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis  highly homologous to vertebrate voltage-gated chloride channels
chrX	510238	513763	510238	513763	-	URB2	YJR041C		510238,	513763,	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
chrX	514054	516289	514054	516289	+	NUP85	YJR042W		514054,	516289,	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)  required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking  the Nup84 subcomplex has a role in transcription elongation
chrX	516460	517513	516460	517513	-	POL32	YJR043C		516460,	517513,	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication  required for error-prone DNA synthesis in the presence of DNA damage and processivity  interacts with Hys2p, PCNA (Pol30p), and Pol1p
chrX	518762	519185	518762	519185	-	VPS55	YJR044C		518762,	519185,	Late endosomal protein involved in late endosome to vacuole trafficking  functional homolog of human obesity receptor gene-related protein (OB-RGRP)
chrX	519637	521602	519637	521602	-	SSC1	YJR045C		519637,	521602,	Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  involved in protein translocation and folding  subunit of SceI endonuclease
chrX	522047	523862	522047	523862	+	TAH11	YJR046W		522047,	523862,	DNA replication licensing factor, required for pre-replication complex assembly
chrX	524907	525381	524907	525381	-	ANB1	YJR047C		524907,	525381,	Translation elongation factor eIF-5A, previously thought to function in translation initiation  similar to and functionally redundant with Hyp2p  undergoes an essential hypusination modification  expressed under anaerobic conditions
chrX	526334	526664	526334	526664	+	CYC1	YJR048W		526334,	526664,	Cytochrome c, isoform 1  electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
chrX	526883	528476	526883	528476	-	UTR1	YJR049C		526883,	528476,	ATP-NADH kinase  phosphorylates both NAD and NADH  active as a hexamer  enhances the activity of ferric reductase (Fre1p)
chrX	528696	529404	528696	529404	+	ISY1	YJR050W		528696,	529404,	Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity  isy1 syf2 cells have defective spindles
chrX	529860	531366	529860	531366	+	OSM1	YJR051W		529860,	531366,	Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions  mutations cause osmotic sensitivity
chrX	532061	533759	532061	533759	+	RAD7	YJR052W		532061,	533759,	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair  subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
chrX	534026	535751	534026	535751	+	BFA1	YJR053W		534026,	535751,	Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
chrX	536055	537549	536055	537549	+	YJR054W	YJR054W		536055,	537549,	Vacuolar protein of unknown function  potential Cdc28p substrate
chrX	538771	539266	538771	539266	+	HIT1	YJR055W		538771,	539266,	Protein of unknown function, required for growth at high temperature
chrX	541791	542502	541791	542502	-	YJR056C	YJR056C		541791,	542502,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrX	544061	544712	544061	544712	+	CDC8	YJR057W		544061,	544712,	Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides  converts dTMP to dTDP and dUMP to dUTP  essential for mitotic and meiotic DNA replication  homologous to S. pombe Tmp1p
chrX	544731	545175	544731	545175	-	APS2	YJR058C		544731,	545175,	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane  related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
chrX	545786	548243	545786	548243	+	PTK2	YJR059W		545786,	548243,	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane  enhances spermine uptake
chrX	548758	549814	548758	549814	+	CBF1	YJR060W		548758,	549814,	Dual function helix-loop-helix protein  binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI)  affects nucleosome positioning at this motif  associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression  associates with kinetochore proteins and required for efficient chromosome segregation
chrX	550510	553318	550510	553318	+	YJR061W	YJR061W		550510,	553318,	Putative protein of unknown function  non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation  transcription repressed by Rm101p
chrX	553475	554849	553475	554849	-	NTA1	YJR062C		553475,	554849,	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
chrX	555194	555572	555194	555572	+	RPA12	YJR063W		555194,	555572,	RNA polymerase I subunit A12.2  contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
chrX	555913	557602	555913	557602	+	CCT5	YJR064W		555913,	557602,	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
chrX	557808	559158	557808	559158	-	ARP3	YJR065C		557808,	559158,	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches  involved in endocytosis and membrane growth and polarity
chrX	559415	566828	559415	566828	+	TOR1	YJR066W		559415,	566828,	PIK-related protein kinase and rapamycin target  subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy  involved in meiosis
chrX	567018	567444	567018	567444	-	YAE1	YJR067C		567018,	567444,	Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions
chrX	567642	568704	567642	568704	+	RFC2	YJR068W		567642,	568704,	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
chrX	568805	569399	568805	569399	-	HAM1	YJR069C		568805,	569399,	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools  mutant is sensitive to the base analog 6-N-hydroxylaminopurine
chrX	569620	570598	569620	570598	-	LIA1	YJR070C		569620,	570598,	Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation  binds to and is required for the modification of Hyp2p (eIF5A)  complements S. pombe mmd1 mutants defective in mitochondrial positioning
chrX	570404	570773	570404	570773	+	YJR071W	YJR071W		570404,	570773,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	570966	572124	570966	572124	-	NPA3	YJR072C		570966,	572124,	Essential, conserved, cytoplasmic ATPase  phosphorylated by the Pcl1p-Pho85p kinase complex
chrX	572314	572935	572314	572935	-	OPI3	YJR073C		572314,	572935,	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
chrX	573094	573751	573094	573751	+	MOG1	YJR074W		573094,	573751,	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
chrX	573980	575171	573980	575171	+	HOC1	YJR075W		573980,	575171,	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis  subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p  identified as a suppressor of a cell lysis sensitive pkc1-371 allele
chrX	575353	576601	575353	576601	-	CDC11	YJR076C		575353,	576601,	Component of the septin ring of the mother-bud neck that is required for cytokinesis  septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
chrX	577254	578190	577254	578190	-	MIR1	YJR077C		577254,	578190,	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria  functionally redundant with Pic2p but more abundant than Pic2p under normal conditions  phosphorylated
chrX	578859	580221	578859	580221	+	BNA2	YJR078W		578859,	580221,	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine  interacts genetically with telomere capping gene CDC13  regulated by Hst1p and Aftp
chrX	580204	581239	580204	581239	+	YJR079W	YJR079W		580204,581052,	580347,581239,	Putative protein of unknown function  mutation results in impaired mitochondrial respiration
chrX	580431	581616	580431	581616	-	AIM24	YJR080C		580431,	581616,	Protein of unknown function  the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies  null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
chrX	581913	582255	581913	582255	-	EAF6	YJR082C		581913,	582255,	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
chrX	582607	583537	582607	583537	-	ACF4	YJR083C		582607,	583537,	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization  potential Cdc28p substrate
chrX	583732	585004	583732	585004	+	CSN12	YJR084W		583732,	585004,	Protein that forms a complex with Thp3p  may have a role in transcription elongation and/or mRNA splicing  identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome
chrX	585119	585437	585119	585437	-	YJR085C	YJR085C		585119,	585437,	Putative protein of unknown function  GFP-fusion protein is induced in response to the DNA-damaging agent MMS  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrX	586067	586400	586067	586400	+	STE18	YJR086W		586067,	586400,	G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling  C-terminus is palmitoylated and farnesylated, which are required for normal signaling
chrX	586399	586750	586399	586750	+	YJR087W	YJR087W		586399,	586750,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  partially overlaps the verified genes STE18 and ECM2
chrX	586494	587373	586494	587373	-	EMC2	YJR088C		586494,	587373,	Member of a transmembrane complex required for efficient folding of proteins in the ER  null mutant displays induction of the unfolded protein response
chrX	587717	590582	587717	590582	+	BIR1	YJR089W		587717,	590582,	Subunit of chromosomal passenger complex (CPC  Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation  required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension
chrX	590871	594327	590871	594327	-	GRR1	YJR090C		590871,	594327,	F-box protein component of the SCF ubiquitin-ligase complex  involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
chrX	595060	598336	595060	598336	-	JSN1	YJR091C		595060,	598336,	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins  involved in localizing the Arp2/3 complex to mitochondria  overexpression causes increased sensitivity to benomyl
chrX	598734	603078	598734	603078	+	BUD4	YJR092W		598734,	603078,	Involved in bud-site selection and required for the axial budding pattern  localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding  required for the formation of a double septin ring, and generally for the organization of septin structures  potential Cdc28p substrate
chrX	603219	604203	603219	604203	-	FIP1	YJR093C		603219,	604203,	Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity  bridging factor that links Pap1p and the CPF complex via Yth1p
chrX	604568	605651	604568	605651	-	IME1	YJR094C		604568,	605651,	Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
chrX	608304	608858	608304	608858	+	RPL43B	YJR094W-A		608304,608581,	608306,608858,	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
chrX	609772	610741	609772	610741	+	SFC1	YJR095W		609772,	610741,	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion  required for ethanol and acetate utilization
chrX	611194	612043	611194	612043	+	YJR096W	YJR096W		611194,	612043,	Putative xylose and arabinose reductase  member of the aldo-keto reductase (AKR) family  GFP-fusion protein is induced in response to the DNA-damaging agent MMS
chrX	612412	612931	612412	612931	+	JJJ3	YJR097W		612412,	612931,	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
chrX	613185	615156	613185	615156	-	YJR098C	YJR098C		613185,	615156,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrX	615575	616286	615575	616286	+	YUH1	YJR099W		615575,	616286,	Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin  hydrolyzes the peptide bond at the C-terminus of ubiquitin  also the major processing enzyme for the ubiquitin-like protein Rub1p
chrX	616350	617334	616350	617334	-	AIM25	YJR100C		616350,	617334,	Putative protein of unknown function  non-tagged protein is detected in purified mitochondria in high-throughput studies  similar to murine NOR1  null mutant is viable and displays elevated frequency of mitochondrial genome loss
chrX	618233	619034	618233	619034	+	RSM26	YJR101W		618233,	619034,	Mitochondrial ribosomal protein of the small subunit
chrX	619156	619765	619156	619765	-	VPS25	YJR102C		619156,	619765,	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
chrX	620753	622490	620753	622490	+	URA8	YJR103W		620753,	622490,	Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines  involved in phospholipid biosynthesis
chrX	622549	623014	622549	623014	-	SOD1	YJR104C		622549,	623014,	Cytosolic copper-zinc superoxide dismutase  some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
chrX	623580	624603	623580	624603	+	ADO1	YJR105W		623580,	624603,	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet)  may be involved in recycling adenosine produced through the methyl cycle
chrX	624837	627015	624837	627015	+	ECM27	YJR106W		624837,	627015,	Putative protein of unknown function  may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B  null mutants have increased plasmid loss  displays a two-hybrid interaction with Pdr5p
chrX	627339	628326	627339	628326	+	YJR107W	YJR107W		627339,	628326,	Putative protein of unknown function  has sequence or structural similarity to lipases
chrX	628711	629083	628711	629083	+	ABM1	YJR108W		628711,	629083,	Protein of unknown function, required for normal microtubule organization
chrX	629584	632941	629584	632941	-	CPA2	YJR109C		629584,	632941,	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
chrX	633614	635681	633614	635681	+	YMR1	YJR110W		633614,	635681,	Phosphatidylinositol 3-phosphate (PI3P) phosphatase  involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport  has similarity to the conserved myotubularin dual specificity phosphatase family
chrX	635854	636706	635854	636706	-	YJR111C	YJR111C		635854,	636706,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
chrX	637029	637635	637029	637635	+	NNF1	YJR112W		637029,	637635,	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules  required for accurate chromosome segregation
chrX	637789	638168	637789	638168	+	YJR112W-A	YJR112W-A		637789,637858,	637809,638168,	Putative protein of unknown function  identified based on homology to Ashbya gossypii
chrX	638231	638975	638231	638975	-	RSM7	YJR113C		638231,	638975,	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
chrX	638658	639051	638658	639051	+	YJR114W	YJR114W		638658,	639051,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF RSM7/YJR113C
chrX	639941	640451	639941	640451	+	YJR115W	YJR115W		639941,	640451,	Putative protein of unknown function
chrX	640824	641664	640824	641664	+	YJR116W	YJR116W		640824,	641664,	Putative protein of unknown function  null mutant is sensitive to expression of the top1-T722A allele
chrX	642006	643368	642006	643368	+	STE24	YJR117W		642006,	643368,	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing  contains multiple transmembrane spans
chrX	643489	644101	643489	644101	-	ILM1	YJR118C		643489,	644101,	Protein of unknown function  may be involved in mitochondrial DNA maintenance  required for slowed DNA synthesis-induced filamentous growth
chrX	644303	646490	644303	646490	-	JHD2	YJR119C		644303,	646490,	JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4)  removes methyl groups specifically added by Set1p methyltransferase  protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
chrX	647125	647476	647125	647476	+	YJR120W	YJR120W		647125,	647476,	Protein of unknown function  essential for growth under anaerobic conditions  mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
chrX	647606	649142	647606	649142	+	ATP2	YJR121W		647606,	649142,	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis  phosphorylated
chrX	649775	651269	649775	651269	+	IBA57	YJR122W		649775,	651269,	Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins  activates the radical-SAM family members Bio2p and Lip5p  interacts with Ccr4p in the two-hybrid system
chrX	651900	652578	651900	652578	+	RPS5	YJR123W		651900,	652578,	Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins  phosphorylated in vivo  essential for viability  has similarity to E. coli S7 and rat S5 ribosomal proteins
chrX	652891	654238	652891	654238	-	YJR124C	YJR124C		652891,	654238,	Putative protein of unknown function  expression induced under calcium shortage
chrX	654736	655963	654736	655963	-	ENT3	YJR125C		654736,	655963,	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes  associates with the clathrin adaptor Gga2p
chrX	656253	658689	656253	658689	-	VPS70	YJR126C		656253,	658689,	Protein of unknown function involved in vacuolar protein sorting
chrX	658916	663059	658916	663059	-	RSF2	YJR127C		658916,	663059,	Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions
chrX	662920	663280	662920	663280	+	YJR128W	YJR128W		662920,	663280,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF RSF2
chrX	663999	665019	663999	665019	-	YJR129C	YJR129C		663999,	665019,	Putative protein of unknown function  predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrX	665217	667137	665217	667137	-	STR2	YJR130C		665217,	667137,	Cystathionine gamma-synthase, converts cysteine into cystathionine
chrX	667643	669293	667643	669293	+	MNS1	YJR131W		667643,	669293,	Alpha-1,2-mannosidase involved in ER quality control  catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis  integral to ER membrane
chrX	669521	672668	669521	672668	+	NMD5	YJR132W		669521,	672668,	Karyopherin, a carrier protein involved in nuclear import of proteins  importin beta homolog
chrX	672990	673620	672990	673620	+	XPT1	YJR133W		672990,	673620,	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
chrX	673728	675852	673728	675852	-	SGM1	YJR134C		673728,	675852,	Protein of unknown function, required for wild-type growth rate on galactose and mannose  localizes to COPI coated vesicles and the Golgi apparatus
chrX	676058	676778	676058	676778	-	MCM22	YJR135C		676058,	676778,	Protein involved in minichromosome maintenance  component of the kinetochore  binds to centromeric DNA in a Ctf19p-dependent manner
chrX	676970	677234	676970	677234	+	TIM8	YJR135W-A		676970,	677234,	Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion  homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
chrX	677440	678706	677440	678706	-	TTI2	YJR136C		677440,	678706,	Putative protein of unknown function  subunit of the ASTRA complex which is part of the chromatin remodeling machinery  similar to S. pombe Tti2p  may interact with Rsm23p  GFP-fusion protein localizes to the cytoplasm
chrX	678956	683285	678956	683285	-	MET5	YJR137C		678956,	683285,	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
chrX	684566	689321	684566	689321	+	IML1	YJR138W		684566,	689321,	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole  has an N-terminal CDC48-like domain and a C-terminal DEP domain  central region is readily accessible to proteases
chrX	689444	690524	689444	690524	-	HOM6	YJR139C		689444,	690524,	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis  enzyme has nucleotide-binding, dimerization and catalytic regions
chrX	690749	695696	690749	695696	-	HIR3	YJR140C		690749,	695696,	Subunit of the HIR complex  a nucleosome assembly complex involved in regulation of histone gene transcription  involved in position-dependent gene silencing and nucleosome reassembly  ortholog of human CABIN1 protein
chrX	690960	691110	690960	691110	+	YJR140W-A	YJR140W-A		690960,	691110,	Dubious open reading frame  completely overlaps the verified gene HIR3  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrX	695905	696949	695905	696949	+	YJR141W	YJR141W		695905,	696949,	Essential protein of unknown function
chrX	697140	698169	697140	698169	+	YJR142W	YJR142W		697140,	698169,	Putative protein of unknown function  GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis  synthetic lethal with PH085 deletion  plays a role in restricting Ty1 transposition
chrX	698325	700614	698325	700614	-	PMT4	YJR143C		698325,	700614,	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues  appears to form homodimers in vivo and does not complex with other Pmt proteins  target for new antifungals
chrX	700881	701691	700881	701691	+	MGM101	YJR144W		700881,	701691,	Protein involved in mitochondrial genome maintenance  component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
chrX	702026	703068	702026	703068	-	RPS4A	YJR145C		702026,703054,	702798,703068,	Protein component of the small (40S) ribosomal subunit  mutation affects 20S pre-rRNA processing  identical to Rps4Bp and has similarity to rat S4 ribosomal protein
chrX	703884	704238	703884	704238	+	YJR146W	YJR146W		703884,	704238,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene HMS2
chrX	704195	705272	704195	705272	+	HMS2	YJR147W		704195,	705272,	Protein with similarity to heat shock transcription factors  overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
chrX	705743	706874	705743	706874	+	BAT2	YJR148W		705743,	706874,	Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism  homolog of murine ECA39  highly expressed during stationary phase and repressed during logarithmic phase
chrX	707159	708374	707159	708374	+	YJR149W	YJR149W		707159,	708374,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrX	708810	709707	708810	709707	-	DAN1	YJR150C		708810,	709707,	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p  expressed under anaerobic conditions, completely repressed during aerobic growth
chrX	712254	715740	712254	715740	-	DAN4	YJR151C		712254,	715740,	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p  expressed under anaerobic conditions, completely repressed during aerobic growth
chrX	717579	717630	717579	717630	+	YJR151W-A	YJR151W-A		717579,	717630,	Putative protein of unknown function  identified by fungal homology and RT-PCR  predicted to have a role in transcription based on computational "guilt by association" analysis
chrX	719665	721297	719665	721297	+	DAL5	YJR152W		719665,	721297,	Allantoate permease  ureidosuccinate permease  also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate  expression is constitutive but sensitive to nitrogen catabolite repression
chrX	722814	723900	722814	723900	+	PGU1	YJR153W		722814,	723900,	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
chrX	725783	726824	725783	726824	+	YJR154W	YJR154W		725783,	726824,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrX	727404	728271	727404	728271	+	AAD10	YJR155W		727404,	728271,	Putative aryl-alcohol dehydrogenase  similar to P. chrysosporium aryl-alcohol dehydrogenase  mutational analysis has not yet revealed a physiological role
chrX	728573	729596	728573	729596	-	THI11	YJR156C		728573,	729596,	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP)  member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
chrX	730514	730877	730514	730877	+	YJR157W	YJR157W		730514,	730877,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrX	732439	734143	732439	734143	+	HXT16	YJR158W		732439,	734143,	Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose
chrX	736043	737117	736043	737117	+	SOR1	YJR159W		736043,	737117,	Sorbitol dehydrogenase  expression is induced in the presence of sorbitol or xylose
chrX	738007	739816	738007	739816	-	MPH3	YJR160C		738007,	739816,	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose  identical to Mph2p  encoded in a subtelomeric position in a region likely to have undergone duplication
chrX	742847	743999	742847	743999	-	COS5	YJR161C		742847,	743999,	Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrX	744910	745261	744910	745261	-	YJR162C	YJR162C		744910,	745261,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXI	450	798	450	798	+	YKL225W	YKL225W		450,	798,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXI	1809	2181	1809	2181	-	PAU16	YKL224C		1809,	2181,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
chrXI	2388	2721	2388	2721	+	YKL223W	YKL223W		2388,	2721,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXI	3502	5620	3502	5620	-	YKL222C	YKL222C		3502,	5620,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  similar to transcriptional regulators from the zinc cluster (binuclear cluster) family  null mutant is sensitive to caffeine
chrXI	6106	7528	6106	7528	+	MCH2	YKL221W		6106,	7528,	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane  mutant is not deficient in monocarboxylate transport
chrXI	9090	11226	9090	11226	-	FRE2	YKL220C		9090,	11226,	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters  expression induced by low iron levels but not by low copper levels
chrXI	14484	15708	14484	15708	+	COS9	YKL219W		14484,	15708,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrXI	17358	18339	17358	18339	-	SRY1	YKL218C		17358,	18339,	3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia  required in the presence of hydroxyaspartate  highly similar to mouse serine racemase (Srr) but has no serine racemase activity
chrXI	22233	24084	22233	24084	+	JEN1	YKL217W		22233,	24084,	Monocarboxylate/proton symporter of the plasma membrane  transport activity is dependent on the pH gradient across the membrane  mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates  expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
chrXI	25214	26159	25214	26159	+	URA1	YKL216W		25214,	26159,	Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
chrXI	26826	30687	26826	30687	-	OXP1	YKL215C		26826,	30687,	5-oxoprolinase  enzyme is ATP-dependent and functions as a dimer  similar to mouse Oplah gene  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXI	31081	31693	31081	31693	-	YRA2	YKL214C		31081,	31693,	Member of the REF (RNA and export factor binding proteins) family  when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
chrXI	31959	34107	31959	34107	-	DOA1	YKL213C		31959,	34107,	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration  also promotes efficient NHEJ in postdiauxic/stationary phase
chrXI	34542	36414	34542	36414	+	SAC1	YKL212W		34542,	36414,	Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P  transmembrane protein localizes to ER and Golgi  involved in protein trafficking and processing, secretion, and cell wall maintenance
chrXI	36698	38153	36698	38153	-	TRP3	YKL211C		36698,	38153,	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
chrXI	39162	42237	39162	42237	+	UBA1	YKL210W		39162,	42237,	Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability
chrXI	42422	46295	42422	46295	-	STE6	YKL209C		42422,	46295,	Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport  contains 12 transmembrane domains and two ATP binding domains  expressed only in MATa cells
chrXI	47156	47972	47156	47972	+	CBT1	YKL208W		47156,	47972,	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts  may also have a role in 3' end processing of the COB pre-mRNA  displays genetic interaction with cell cycle-regulated kinase Dbf2p
chrXI	48193	48955	48193	48955	+	AIM27	YKL207W		48193,	48955,	Member of a transmembrane complex required for efficient folding of proteins in the ER  required for respiratory growth  null mutant displays induction of the unfolded protein response
chrXI	49005	49809	49005	49809	-	ADD66	YKL206C		49005,	49809,	Protein involved in 20S proteasome assembly  forms a heterodimer with Pba1p that binds to proteasome precursors  similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
chrXI	50050	53353	50050	53353	+	LOS1	YKL205W		50050,	53353,	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
chrXI	53703	55602	53703	55602	+	EAP1	YKL204W		53703,	55602,	eIF4E-associated protein, competes with eIF4G for binding to eIF4E  inhibits cap-dependent translation  functions independently of eIF4E to maintain genetic stability  plays a role in cell growth, implicated in the TOR signaling cascade
chrXI	55934	63359	55934	63359	-	TOR2	YKL203C		55934,	63359,	PIK-related protein kinase and rapamycin target  subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton  involved in meiosis
chrXI	63820	64402	63820	64402	+	YKL202W	YKL202W		63820,	64402,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXI	63929	67466	63929	67466	-	MNN4	YKL201C		63929,	67466,	Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides  expression increases in late-logarithmic and stationary growth phases
chrXI	68231	70220	68231	70220	-	PTK1	YKL198C		68231,	70220,	Putative serine/threonine protein kinase that regulates spermine uptake  involved in polyamine transport  possible mitochondrial protein
chrXI	70733	73865	70733	73865	-	PEX1	YKL197C		70733,	73865,	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol  induced by oleic acid and upregulated during anaerobiosis
chrXI	74931	75534	74931	75534	-	YKT6	YKL196C		74931,	75534,	Vesicle membrane protein (v-SNARE) with acyltransferase activity  involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion  membrane localization due to prenylation at the carboxy-terminus
chrXI	75820	77032	75820	77032	+	MIA40	YKL195W		75820,	77032,	Essential protein of the mitochondrial intermembrane space (IMS)  promotes retention of newly imported proteins  may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins
chrXI	77257	78646	77257	78646	-	MST1	YKL194C		77257,	78646,	Mitochondrial threonyl-tRNA synthetase
chrXI	78865	79882	78865	79882	-	SDS22	YKL193C		78865,	79882,	Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis
chrXI	80159	80537	80159	80537	-	ACP1	YKL192C		80159,	80537,	Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid  activated by phosphopantetheinylation catalyzed by Ppt2p
chrXI	81034	82639	81034	82639	+	DPH2	YKL191W		81034,	82639,	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p)  may act in a complex with Dph1p and Kti11p
chrXI	82946	83550	82946	83550	+	CNB1	YKL190W		82946,83074,	82998,83550,	Calcineurin B  the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
chrXI	84703	85903	84703	85903	+	HYM1	YKL189W		84703,	85903,	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
chrXI	86224	88786	86224	88786	-	PXA2	YKL188C		86224,	88786,	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes  similarity to human adrenoleukodystrophy transporter and ALD-related proteins
chrXI	89283	91536	89283	91536	-	YKL187C	YKL187C		89283,	91536,	Putative protein of unknown function  the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
chrXI	92743	93298	92743	93298	-	MTR2	YKL186C		92743,	93298,	mRNA transport regulator, essential nuclear protein  Mex67p and Mtr2p form a mRNA export complex which binds to RNA
chrXI	94498	96265	94498	96265	+	ASH1	YKL185W		94498,	96265,	Zinc-finger inhibitor of HO transcription  mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression  potential Cdc28p substrate
chrXI	96756	98157	96756	98157	+	SPE1	YKL184W		96756,	98157,	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis  degraded in a proteasome-dependent manner in the presence of excess polyamines  deletion decreases lifespan, and increases necrotic cell death and ROS generation
chrXI	98394	98607	98394	98607	-	YKL183C-A	YKL183C-A		98394,	98607,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXI	98720	99641	98720	99641	+	LOT5	YKL183W		98720,	99641,	Protein of unknown function  gene expression increases in cultures shifted to a lower temperature
chrXI	100670	106826	100670	106826	+	FAS1	YKL182W		100670,	106826,	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids  contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
chrXI	107315	108599	107315	108599	+	PRS1	YKL181W		107315,	108599,	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis  one of five related enzymes, which are active as heteromultimeric complexes
chrXI	109268	110129	109268	110129	+	RPL17A	YKL180W		109268,109883,	109577,110129,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins  copurifies with the Dam1 complex (aka DASH complex)
chrXI	110463	112503	110463	112503	-	COY1	YKL179C		110463,	112503,	Golgi membrane protein with similarity to mammalian CASP  genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
chrXI	113214	114627	113214	114627	-	STE3	YKL178C		113214,	114627,	Receptor for a factor pheromone, couples to MAP kinase cascade to mediate pheromone response  transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane  GPCR
chrXI	114355	114694	114355	114694	+	YKL177W	YKL177W		114355,	114694,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene STE3
chrXI	115499	117986	115499	117986	-	LST4	YKL176C		115499,	117986,	Protein possibly involved in a post-Golgi secretory pathway  required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
chrXI	118792	120304	118792	120304	+	ZRT3	YKL175W		118792,	120304,	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed  transcription is induced under conditions of zinc deficiency
chrXI	120379	122236	120379	122236	-	TPO5	YKL174C		120379,	122236,	Protein involved in excretion of putrescine and spermidine  putative polyamine transporter in the Golgi or post-Golgi vesicles
chrXI	122516	125543	122516	125543	+	SNU114	YKL173W		122516,	125543,	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome  binds directly to U5 snRNA  proposed to be involved in conformational changes of the spliceosome  similarity to ribosomal translocation factor EF-2
chrXI	125758	127042	125758	127042	+	EBP2	YKL172W		125758,	127042,	Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus  constituent of 66S pre-ribosomal particles
chrXI	127474	130261	127474	130261	+	NNK1	YKL171W		127474,	130261,	Protein kinase  implicated in proteasome function  interacts with TORC1, Ure2 and Gdh2  overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3  epitope-tagged protein localizes to the cytoplasm
chrXI	130633	131050	130633	131050	+	MRPL38	YKL170W		130633,	131050,	Mitochondrial ribosomal protein of the large subunit  appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
chrXI	130684	131068	130684	131068	-	YKL169C	YKL169C		130684,	131068,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene MRPL38
chrXI	131287	133462	131287	133462	-	KKQ8	YKL168C		131287,	133462,	Putative serine/threonine protein kinase with unknown cellular role
chrXI	133720	134134	133720	134134	-	MRP49	YKL167C		133720,	134134,	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
chrXI	134508	135705	134508	135705	-	TPK3	YKL166C		134508,	135705,	cAMP-dependent protein kinase catalytic subunit  promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway  partially redundant with Tpk1p and Tpk2p  localizes to P-bodies during stationary phase
chrXI	135789	136023	135789	136023	-	YKL165C-A	YKL165C-A		135789,	136023,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXI	137931	140691	137931	140691	-	MCD4	YKL165C		137931,	140691,	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis  multimembrane-spanning protein that localizes to the endoplasmic reticulum  highly conserved among eukaryotes
chrXI	141793	142819	141793	142819	-	PIR1	YKL164C		141793,	142819,	O-glycosylated protein required for cell wall stability  attached to the cell wall via beta-1,3-glucan  mediates mitochondrial translocation of Apn1p  expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
chrXI	144400	145378	144400	145378	+	PIR3	YKL163W		144400,	145378,	O-glycosylated covalently-bound cell wall protein required for cell wall stability  expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
chrXI	145921	146074	145921	146074	-	YKL162C-A	YKL162C-A		145921,	146074,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXI	147629	148838	147629	148838	-	YKL162C	YKL162C		147629,	148838,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
chrXI	149385	150687	149385	150687	-	KDX1	YKL161C		149385,	150687,	Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway  interacts with numerous components in the mating pheromone and CWI MAPK pathways  associates with Rlm1p
chrXI	153268	153706	153268	153706	+	ELF1	YKL160W		153268,	153706,	Transcription elongation factor that contains a conserved zinc finger domain  implicated in the maintenance of proper chromatin structure in actively transcribed regions  deletion inhibits Brome mosaic virus (BMV) gene expression
chrXI	153815	154451	153815	154451	-	RCN1	YKL159C		153815,	154451,	Protein involved in calcineurin regulation during calcium signaling  has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
chrXI	154990	158232	154990	158232	+	APE2	YKL157W		154990,155654,	155271,158232,	Aminopeptidase yscII  may have a role in obtaining leucine from dipeptide substrates  sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W
chrXI	158612	159212	158612	159212	+	RPS27A	YKL156W		158612,158966,	158615,159212,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein
chrXI	158974	159091	158974	159091	-	YKL156C-A	YKL156C-A		158974,	159091,	Dubious open reading frame unlikely to encode a protein  completely overlaps the verified gene RPS27A  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXI	159455	161342	159455	161342	-	RSM22	YKL155C		159455,	161342,	Mitochondrial ribosomal protein of the small subunit  also predicted to be an S-adenosylmethionine-dependent methyltransferase
chrXI	161600	162335	161600	162335	+	SRP102	YKL154W		161600,	162335,	Signal recognition particle (SRP) receptor beta subunit  involved in SRP-dependent protein targeting  anchors the alpha subunit, Srp101p to the ER membrane
chrXI	163599	164109	163599	164109	+	YKL153W	YKL153W		163599,	164109,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
chrXI	163641	164385	163641	164385	-	GPM1	YKL152C		163641,	164385,	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
chrXI	164916	165930	164916	165930	-	YKL151C	YKL151C		164916,	165930,	Putative protein of unknown function  YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXI	166543	167452	166543	167452	+	MCR1	YKL150W		166543,	167452,	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
chrXI	167611	168829	167611	168829	-	DBR1	YKL149C		167611,	168829,	RNA lariat debranching enzyme, involved in intron turnover  required for efficient Ty1 transposition
chrXI	169206	171129	169206	171129	-	SDH1	YKL148C		169206,	171129,	Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
chrXI	171550	172168	171550	172168	-	YKL147C	YKL147C		171550,	172168,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  partially overlaps the verified gene AVT3
chrXI	171782	173861	171782	173861	+	AVT3	YKL146W		171782,	173861,	Vacuolar transporter, exports large neutral amino acids from the vacuole  member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
chrXI	174212	175616	174212	175616	+	RPT1	YKL145W		174212,	175616,	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates  required for optimal CDC20 transcription  interacts with Rpn12p and Ubr1p  mutant has aneuploidy tolerance
chrXI	174957	175050	174957	175050	+	YKL145W-A	YKL145W-A		174957,	175050,	Dubious open reading frame, unlikely to encode a protein  completely overlaps the verified essential gene RPT1  identified by expression profiling and mass spectrometry
chrXI	175842	176481	175842	176481	-	RPC25	YKL144C		175842,	176481,	RNA polymerase III subunit C25, required for transcription initiation  forms a heterodimer with Rpc17p  paralog of Rpb7p
chrXI	176780	178172	176780	178172	+	LTV1	YKL143W		176780,	178172,	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p  required for ribosomal small subunit export from nucleus  required for growth at low temperature
chrXI	178514	179174	178514	179174	+	MRP8	YKL142W		178514,	179174,	Protein of unknown function  undergoes sumoylation  transcription induced under cell wall stress  protein levels are reduced under anaerobic conditions  originally thought to be a mitochondrial ribosomal protein based on sequence analysis
chrXI	179666	180263	179666	180263	+	SDH3	YKL141W		179666,	180263,	Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
chrXI	180778	182425	180778	182425	+	TGL1	YKL140W		180778,	182425,	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis  localized to lipid particle membranes
chrXI	182957	184544	182957	184544	+	CTK1	YKL139W		182957,	184544,	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I)  phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity  similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
chrXI	184802	185012	184802	185012	-	HSK3	YKL138C-A		184802,	185012,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  is transferred to the kinetochore prior to mitosis
chrXI	185285	185681	185285	185681	-	MRPL31	YKL138C		185285,	185681,	Mitochondrial ribosomal protein of the large subunit
chrXI	185956	186292	185956	186292	+	CMC1	YKL137W		185956,	186292,	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex  contains a twin CX9C motif
chrXI	186415	186814	186415	186814	+	YKL136W	YKL136W		186415,	186814,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF APL2/YKL135C
chrXI	186459	188640	186459	188640	-	APL2	YKL135C		186459,	188640,	Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex  binds clathrin  involved in clathrin-dependent Golgi protein sorting
chrXI	189123	191442	189123	191442	-	OCT1	YKL134C		189123,	191442,	Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p)  may contribute to mitochondrial iron homeostasis
chrXI	191678	193070	191678	193070	-	YKL133C	YKL133C		191678,	193070,	Putative protein of unknown function  has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
chrXI	193573	194866	193573	194866	-	RMA1	YKL132C		193573,	194866,	Putative dihydrofolate synthetase  has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXI	194477	194999	194477	194999	+	YKL131W	YKL131W		194477,	194999,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXI	195287	196028	195287	196028	-	SHE2	YKL130C		195287,	196028,	RNA-binding protein that binds specific mRNAs and interacts with She3p  part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
chrXI	196348	200167	196348	200167	-	MYO3	YKL129C		196348,	200167,	One of two type I myosins  localizes to actin cortical patches  deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
chrXI	200883	201771	200883	201771	-	PMU1	YKL128C		200883,	201771,	Putative phosphomutase, contains a region homologous to the active site of phosphomutases  overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
chrXI	203540	205253	203540	205253	+	PGM1	YKL127W		203540,	205253,	Phosphoglucomutase, minor isoform  catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
chrXI	205706	207749	205706	207749	+	YPK1	YKL126W		205706,	207749,	Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p  mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways  homolog of mammalian kinase SGK
chrXI	208246	210130	208246	210130	+	RRN3	YKL125W		208246,	210130,	Protein required for transcription of rDNA by RNA polymerase I  transcription factor independent of DNA template  involved in recruitment of RNA polymerase I to rDNA
chrXI	210592	212332	210592	212332	+	SSH4	YKL124W		210592,	212332,	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body  identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
chrXI	212042	212423	212042	212423	+	YKL123W	YKL123W		212042,	212423,	Dubious open reading frame, unlikely to encode a protein  partially overlaps the verified gene SSH4
chrXI	212494	212998	212494	212998	-	SRP21	YKL122C		212494,	212998,	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane  not found in mammalian SRP  forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
chrXI	214141	216700	214141	216700	+	DGR2	YKL121W		214141,	216700,	Protein of unknown function  null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
chrXI	217343	218318	217343	218318	+	OAC1	YKL120W		217343,	218318,	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate  member of the mitochondrial carrier family
chrXI	218569	219217	218569	219217	-	VPH2	YKL119C		218569,	219217,	Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex  functions in the assembly of the V-ATPase  localized to the endoplasmic reticulum (ER)
chrXI	219125	219437	219125	219437	+	YKL118W	YKL118W		219125,	219437,	Dubious open reading frame, unlikely to encode a protein  partially overlaps the verified gene VPH2
chrXI	220323	220974	220323	220974	+	SBA1	YKL117W		220323,	220974,	Co-chaperone that binds to and regulates Hsp90 family chaperones  important for pp60v-src activity in yeast  homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
chrXI	221343	222900	221343	222900	-	PRR1	YKL116C		221343,	222900,	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
chrXI	222892	223285	222892	223285	-	YKL115C	YKL115C		222892,	223285,	Dubious open reading frame, unlikely to encode a protein  partially overlaps the verified gene PRR1
chrXI	223351	224455	223351	224455	-	APN1	YKL114C		223351,	224455,	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents  also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
chrXI	224726	225875	224726	225875	-	RAD27	YKL113C		224726,	225875,	5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair  member of the S. pombe RAD2/FEN1 family
chrXI	226569	228765	226569	228765	+	ABF1	YKL112W		226569,	228765,	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
chrXI	228463	228799	228463	228799	-	YKL111C	YKL111C		228463,	228799,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  partially overlaps the verified essential gene ABF1
chrXI	228938	229880	228938	229880	-	KTI12	YKL110C		228938,	229880,	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA  involved in sensitivity to G1 arrest induced by zymocin  interacts with chromatin throughout the genome  also interacts with Cdc19p
chrXI	232226	233891	232226	233891	+	HAP4	YKL109W		232226,	233891,	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression  provides the principal activation function of the complex
chrXI	234425	235787	234425	235787	+	SLD2	YKL108W		234425,	235787,	Single-stranded DNA origin-binding and annealing protein  required for the initiation of DNA replication  phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation  component of the preloading complex  required for the S phase checkpoint
chrXI	236140	237070	236140	237070	+	YKL107W	YKL107W		236140,	237070,	Putative protein of unknown function  proposed to be a palmitoylated membrane protein
chrXI	237146	237266	237146	237266	-	YKL106C-A	YKL106C-A		237146,	237266,	Putative protein of unknown function  identified by homology to uncharacterized proteins in other fungi
chrXI	237535	238891	237535	238891	+	AAT1	YKL106W		237535,	238891,	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
chrXI	239184	242583	239184	242583	-	YKL105C	YKL105C		239184,	242583,	Putative protein of unknown function  similar to A. gossypii SEG gene which is important for stabilizing eisosomes
chrXI	243219	245373	243219	245373	-	GFA1	YKL104C		243219,	245373,	Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
chrXI	246137	247682	246137	247682	-	LAP4	YKL103C		246137,	247682,	Vacuolar aminopeptidase yscI  zinc metalloproteinase that belongs to the peptidase family M18  often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
chrXI	248061	248367	248061	248367	-	YKL102C	YKL102C		248061,	248367,	Dubious open reading frame unlikely to encode a functional protein  deletion confers sensitivity to citric acid  predicted protein would include a thiol-disulfide oxidoreductase active site
chrXI	248919	253476	248919	253476	+	HSL1	YKL101W		248919,	253476,	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints  associates with the assembled septin filament  required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
chrXI	253696	255460	253696	255460	-	YKL100C	YKL100C		253696,	255460,	Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases  YKL100C is not an essential gene
chrXI	254158	254248	254158	254248	+	YKL100W-A	YKL100W-A		254158,	254248,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXI	255719	256472	255719	256472	-	UTP11	YKL099C		255719,	256472,	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
chrXI	256769	257843	256769	257843	+	MTC2	YKL098W		256769,	257843,	Protein of unknown function  mtc2 is synthetically sick with cdc13-1
chrXI	258502	258913	258502	258913	-	YKL097C	YKL097C		258502,	258913,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species
chrXI	259072	259222	259072	259222	-	YKL096C-B	YKL096C-B		259072,	259222,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXI	259252	259531	259252	259531	+	CWP2	YKL096W-A		259252,	259531,	Covalently linked cell wall mannoprotein, major constituent of the cell wall  plays a role in stabilizing the cell wall  involved in low pH resistance  precursor is GPI-anchored
chrXI	261131	261851	261131	261851	+	CWP1	YKL096W		261131,	261851,	Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond  required for propionic acid resistance
chrXI	262276	263113	262276	263113	+	YJU2	YKL095W		262276,	263113,	Essential protein required for pre-mRNA splicing  associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic reaction of splicing
chrXI	263348	264290	263348	264290	+	YJU3	YKL094W		263348,	264290,	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
chrXI	264788	265808	264788	265808	+	MBR1	YKL093W		264788,	265808,	Protein involved in mitochondrial functions and stress response  overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
chrXI	266144	269459	266144	269459	-	BUD2	YKL092C		266144,	269459,	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns  mutants exhibit random budding in all cell types
chrXI	269717	270650	269717	270650	-	YKL091C	YKL091C		269717,	270650,	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism  localizes to the nucleus  contains a CRAL/TRIO domain and binds several lipids in a large-scale study
chrXI	271877	273209	271877	273209	+	CUE2	YKL090W		271877,	273209,	Protein of unknown function  has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
chrXI	273393	275043	273393	275043	+	MIF2	YKL089W		273393,	275043,	Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p
chrXI	275282	276998	275282	276998	+	CAB3	YKL088W		275282,	276998,	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC  Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis  null mutant lethality is complemented by E. coli coaBC
chrXI	277188	277863	277188	277863	-	CYT2	YKL087C		277188,	277863,	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase  links heme covalently to apocytochrome c1
chrXI	278280	278664	278280	278664	+	SRX1	YKL086W		278280,	278664,	Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants  conserved in higher eukaryotes
chrXI	279122	280127	279122	280127	+	MDH1	YKL085W		279122,	280127,	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate  involved in the tricarboxylic acid (TCA) cycle  phosphorylated
chrXI	280508	280859	280508	280859	+	HOT13	YKL084W		280508,	280859,	Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins  binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
chrXI	280920	281535	280920	281535	+	YKL083W	YKL083W		280920,	281535,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  partially overlaps the verified essential gene RRP14
chrXI	281024	282329	281024	282329	-	RRP14	YKL082C		281024,	282329,	Essential protein, constituent of 66S pre-ribosomal particles  interacts with proteins involved in ribosomal biogenesis and cell polarity  member of the SURF-6 family
chrXI	282890	284455	282890	284455	+	TEF4	YKL081W		282890,283421,	283095,284455,	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex
chrXI	285029	286208	285029	286208	+	VMA5	YKL080W		285029,	286208,	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system  required for the V1 domain to assemble onto the vacuolar membrane
chrXI	286602	288573	286602	288573	+	SMY1	YKL079W		286602,	288573,	Protein that interacts with Myo2p, proposed to be involved in exocytosis  N-terminal domain is related to the motor domain of kinesins
chrXI	288844	291052	288844	291052	+	DHR2	YKL078W		288844,	291052,	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
chrXI	291452	292631	291452	292631	+	YKL077W	YKL077W		291452,	292631,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole
chrXI	292837	293221	292837	293221	-	PSY1	YKL076C		292837,	293221,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  69% of ORF overlaps the uncharacterized ORF YKL075C
chrXI	292955	294308	292955	294308	-	YKL075C	YKL075C		292955,	294308,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  proposed to be involved in resistance to streptozotocin and camptothecin
chrXI	294609	296193	294609	296193	-	MUD2	YKL074C		294609,	296193,	Protein involved in early pre-mRNA splicing  component of the pre-mRNA-U1 snRNP complex, the commitment complex  interacts with Msl5p/BBP splicing factor and Sub2p  similar to metazoan splicing factor U2AF65
chrXI	296429	299075	296429	299075	+	LHS1	YKL073W		296429,	299075,	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding  nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p  regulated by the unfolded protein response pathway
chrXI	299581	301882	299581	301882	+	STB6	YKL072W		299581,	301882,	Protein that binds Sin3p in a two-hybrid assay
chrXI	305113	305884	305113	305884	+	YKL071W	YKL071W		305113,	305884,	Putative protein of unknown function  expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXI	306210	306720	306210	306720	+	YKL070W	YKL070W		306210,	306720,	Putative protein of unknown function  expression induced in cells treated with mycotoxins patulin or citrinin  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXI	307284	307827	307284	307827	+	YKL069W	YKL069W		307284,	307827,	Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage  has a role in protection against oxidative stress
chrXI	309205	309442	309205	309442	+	YKL068W-A	YKL068W-A		309205,	309442,	Putative protein of unknown function  identified by homology to Ashbya gossypii
chrXI	310198	313078	310198	313078	+	NUP100	YKL068W		310198,	313078,	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore  contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p  homologous to Nup116p
chrXI	314811	315273	314811	315273	+	YNK1	YKL067W		314811,	315273,	Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
chrXI	315280	315724	315280	315724	+	YKL066W	YKL066W		315280,	315724,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  partially overlaps the verified gene YNK1
chrXI	315953	316175	315953	316175	+	YKL065W-A	YKL065W-A		315953,	316175,	Putative protein of unknown function
chrXI	316436	317057	316436	317057	-	YET1	YKL065C		316436,	317057,	Endoplasmic reticulum transmembrane protein  may interact with ribosomes, based on co-purification experiments  homolog of human BAP31 protein
chrXI	317763	320673	317763	320673	+	MNR2	YKL064W		317763,	320673,	Vacuolar membrane protein required for magnesium homeostasis  putative magnesium transporter  has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
chrXI	321014	321518	321014	321518	-	YKL063C	YKL063C		321014,	321518,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the Golgi
chrXI	323227	325120	323227	325120	+	MSN4	YKL062W		323227,	325120,	Transcriptional activator related to Msn2p  activated in stress conditions, which results in translocation from the cytoplasm to the nucleus  binds DNA at stress response elements of responsive genes, inducing gene expression
chrXI	325770	326112	325770	326112	+	BLI1	YKL061W		325770,	326112,	Putative protein of unknown function  likely member of BLOC complex involved in endosomal cargo sorting  green fluorescent protein (GFP)-fusion protein localizes to the endosome
chrXI	326407	327487	326407	327487	-	FBA1	YKL060C		326407,	327487,	Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis  catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P  locates to mitochondrial outer surface upon oxidative stress
chrXI	328117	329443	328117	329443	-	MPE1	YKL059C		328117,	329443,	Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
chrXI	330165	330534	330165	330534	+	TOA2	YKL058W		330165,	330534,	TFIIA small subunit  involved in transcriptional activation, acts as antirepressor or as coactivator  homologous to smallest subunit of human and Drosophila TFIIA
chrXI	330855	333969	330855	333969	-	NUP120	YKL057C		330855,	333969,	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)  required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p  the Nup84 subcomplex has a role in transcription elongation
chrXI	334411	334915	334411	334915	-	TMA19	YKL056C		334411,	334915,	Protein that associates with ribosomes  homolog of translationally controlled tumor protein  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
chrXI	335320	336157	335320	336157	-	OAR1	YKL055C		335320,	336157,	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p
chrXI	336536	338753	336536	338753	-	DEF1	YKL054C		336536,	338753,	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex  mutant is deficient in Zip1p loading onto chromosomes during meiosis
chrXI	339181	339442	339181	339442	-	MDM35	YKL053C-A		339181,	339442,	Mitochondrial intermembrane space protein  mutation affects mitochondrial distribution and morphology  contains twin cysteine-x9-cysteine motifs
chrXI	339571	339946	339571	339946	+	YKL053W	YKL053W		339571,	339946,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF ASK1
chrXI	339667	340546	339667	340546	-	ASK1	YKL052C		339667,	340546,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  phosphorylated during the cell cycle by cyclin-dependent kinases
chrXI	341311	342373	341311	342373	+	SFK1	YKL051W		341311,	342373,	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
chrXI	342851	345620	342851	345620	-	YKL050C	YKL050C		342851,	345620,	Protein of unknown function  the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
chrXI	346074	346764	346074	346764	-	CSE4	YKL049C		346074,	346764,	Centromere protein that resembles histone H3, required for proper kinetochore function  homolog of human CENP-A  levels are regulated by E3 ubiquitin ligase Psh1p
chrXI	347213	349136	347213	349136	-	ELM1	YKL048C		347213,	349136,	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis  required for the regulation of other kinases  forms part of the bud neck ring
chrXI	349462	351013	349462	351013	+	YKL047W	YKL047W		349462,	351013,	Putative protein of unknown function, predicted to be palmitoylated  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXI	351274	352624	351274	352624	-	DCW1	YKL046C		351274,	352624,	Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation homologous to Dfg5p
chrXI	353492	355079	353492	355079	+	PRI2	YKL045W		353492,	355079,	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
chrXI	356321	356642	356321	356642	+	YKL044W	YKL044W		356321,	356642,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXI	356747	357848	356747	357848	+	PHD1	YKL043W		356747,	357848,	Transcriptional activator that enhances pseudohyphal growth  physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets  regulates expression of FLO11, an adhesin required for pseudohyphal filament formation  similar to StuA, an A. nidulans developmental regulator  potential Cdc28p substrate
chrXI	358474	359566	358474	359566	+	SPC42	YKL042W		358474,	359566,	Central plaque component of spindle pole body (SPB)  involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
chrXI	360142	360817	360142	360817	+	VPS24	YKL041W		360142,	360817,	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III)  forms an ESCRT-III subcomplex with Did4p  involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
chrXI	361057	361828	361057	361828	-	NFU1	YKL040C		361057,	361828,	Protein involved in iron metabolism in mitochondria  similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
chrXI	362621	364193	362621	364193	+	PTM1	YKL039W		362621,	364193,	Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p
chrXI	365604	369117	365604	369117	+	RGT1	YKL038W		365604,	369117,	Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose  binds to promoters and acts both as a transcriptional activator and repressor
chrXI	369364	369721	369364	369721	+	AIM26	YKL037W		369364,	369721,	Putative protein of unknown function  null mutant is viable and displays elevated frequency of mitochondrial genome loss  null mutation confers sensitivity to tunicamycin and DTT
chrXI	369527	369920	369527	369920	-	YKL036C	YKL036C		369527,	369920,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
chrXI	369890	371390	369890	371390	+	UGP1	YKL035W		369890,	371390,	UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p
chrXI	371828	374105	371828	374105	+	TUL1	YKL034W		371828,	374105,	Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes
chrXI	374504	375215	374504	375215	+	YKL033W-A	YKL033W-A		374504,	375215,	Putative protein of unknown function  similar to uncharacterized proteins from other fungi
chrXI	375455	378572	375455	378572	+	TTI1	YKL033W		375455,	378572,	Putative protein of unknown function  subunit of the ASTRA complex which is part of the chromatin remodeling machinery  similar to S. pombe Tti1p  detected in highly purified mitochondria in high-throughput studies
chrXI	380064	381858	380064	381858	-	IXR1	YKL032C		380064,	381858,	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA  mediates aerobic transcriptional repression of COX5b
chrXI	382071	382485	382071	382485	+	YKL031W	YKL031W		382071,	382485,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species
chrXI	382497	383103	382497	383103	+	YKL030W	YKL030W		382497,	383103,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  partially overlaps the verified gene MAE1
chrXI	382715	384725	382715	384725	-	MAE1	YKL029C		382715,	384725,	Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
chrXI	385757	387206	385757	387206	+	TFA1	YKL028W		385757,	387206,	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
chrXI	387561	388905	387561	388905	+	YKL027W	YKL027W		387561,	388905,	Protein of unknown function, localized to the mitochondrial outer membrane
chrXI	389379	389883	389379	389883	-	GPX1	YKL026C		389379,	389883,	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
chrXI	390239	392279	390239	392279	-	PAN3	YKL025C		390239,	392279,	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
chrXI	392525	393140	392525	393140	-	URA6	YKL024C		392525,	393140,	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
chrXI	393145	393373	393145	393373	-	YKL023C-A	YKL023C-A		393145,	393373,	Putative protein of unknown function
chrXI	393720	394554	393720	394554	+	YKL023W	YKL023W		393720,	394554,	Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXI	394725	397248	394725	397248	-	CDC16	YKL022C		394725,	397248,	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition  required for sporulation
chrXI	397343	398750	397343	398750	-	MAK11	YKL021C		397343,	398750,	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis  essential for cell growth and replication of killer M1 dsRNA virus  contains four beta-transducin repeats
chrXI	398831	402080	398831	402080	-	SPT23	YKL020C		398831,	402080,	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p  inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
chrXI	402567	403518	402567	403518	+	RAM2	YKL019W		402567,	403518,	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif  essential protein required for membrane localization of Ras proteins and a-factor
chrXI	403579	403879	403579	403879	-	YKL018C-A	YKL018C-A		403579,	403879,	Putative protein of unknown function  identified by homology  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXI	404101	405091	404101	405091	+	SWD2	YKL018W		404101,	405091,	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing  subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
chrXI	405189	407241	405189	407241	-	HCS1	YKL017C		405189,	407241,	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis  contains single-stranded DNA stimulated ATPase and dATPase activities  replication protein A stimulates helicase and ATPase activities
chrXI	407464	407989	407464	407989	-	ATP7	YKL016C		407464,	407989,	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
chrXI	408543	411483	408543	411483	+	PUT3	YKL015W		408543,	411483,	Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state  has a Zn(2)-Cys(6) binuclear cluster domain
chrXI	411618	416913	411618	416913	-	URB1	YKL014C		411618,	416913,	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle  proposed to be involved in the biogenesis of the 60S ribosomal subunit
chrXI	417507	418023	417507	418023	-	ARC19	YKL013C		417507,	418023,	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
chrXI	418309	420061	418309	420061	+	PRP40	YKL012W		418309,	420061,	U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
chrXI	420154	421216	420154	421216	-	CCE1	YKL011C		420154,	421216,	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
chrXI	421423	425875	421423	425875	-	UFD4	YKL010C		421423,	425875,	Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome  cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
chrXI	426241	426952	426241	426952	+	MRT4	YKL009W		426241,	426952,	Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
chrXI	427294	428551	427294	428551	-	LAC1	YKL008C		427294,	428551,	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
chrXI	429301	430108	429301	430108	+	CAP1	YKL007W		429301,	430108,	Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization  localized predominantly to cortical actin patches
chrXI	430197	430632	430197	430632	-	SFT1	YKL006C-A		430197,430596,	430455,430632,	Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
chrXI	431905	432720	431905	432720	+	RPL14A	YKL006W		431905,432432,	432034,432720,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein  rpl14a csh5 double null mutant exhibits synthetic slow growth
chrXI	433092	434877	433092	434877	-	BYE1	YKL005C		433092,	434877,	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
chrXI	435579	436785	435579	436785	+	AUR1	YKL004W		435579,	436785,	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis  can mutate to confer aureobasidin A resistance
chrXI	437096	437492	437096	437492	-	MRP17	YKL003C		437096,	437492,	Mitochondrial ribosomal protein of the small subunit  MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
chrXI	437777	438544	437777	438544	+	DID4	YKL002W		437777,437905,	437837,438544,	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
chrXI	438776	439385	438776	439385	-	MET14	YKL001C		438776,	439385,	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
chrXI	440607	442722	440607	442722	-	VPS1	YKR001C		440607,	442722,	Dynamin-like GTPase required for vacuolar sorting  also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
chrXI	443231	444938	443231	444938	+	PAP1	YKR002W		443231,	444938,	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export  may also polyadenylate rRNAs
chrXI	445380	446727	445380	446727	+	OSH6	YKR003W		445380,	446727,	Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability  GFP-fusion protein localizes to the cell periphery
chrXI	446798	448036	446798	448036	-	ECM9	YKR004C		446798,447810,	447706,448036,	Non-essential protein of unknown function
chrXI	448520	450167	448520	450167	-	YKR005C	YKR005C		448520,450020,	449951,450167,	Putative protein of unknown function
chrXI	450422	451217	450422	451217	-	MRPL13	YKR006C		450422,	451217,	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
chrXI	451433	451988	451433	451988	+	MEH1	YKR007W		451433,	451988,	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p  loss results in a defect in vacuolar acidification
chrXI	452200	454078	452200	454078	+	RSC4	YKR008W		452200,	454078,	Component of the RSC chromatin remodeling complex  found in close proximity to nucleosomal DNA  displaced from the surface of nucleosomal DNA after chromatin remodeling  acetylated (K25) by Gcn5p, altering replication stress tolerance  contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
chrXI	454351	457054	454351	457054	-	FOX2	YKR009C		454351,	457054,	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway  has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
chrXI	458923	461239	458923	461239	-	TOF2	YKR010C		458923,	461239,	Protein required for rDNA silencing and mitotic rDNA condensation  stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation  required for condensin recruitment to the replication fork barrier site
chrXI	461634	462696	461634	462696	-	YKR011C	YKR011C		461634,	462696,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus
chrXI	463738	464116	463738	464116	-	YKR012C	YKR012C		463738,	464116,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene PRY2
chrXI	463958	464948	463958	464948	+	PRY2	YKR013W		463958,	464948,	Protein of unknown function
chrXI	465366	466071	465366	466071	-	YPT52	YKR014C		465366,	466071,	Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5  required for vacuolar protein sorting and endocytosis
chrXI	466960	468667	466960	468667	-	YKR015C	YKR015C		466960,	468667,	Putative protein of unknown function
chrXI	469716	471339	469716	471339	+	FCJ1	YKR016W		469716,	471339,	Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions  impairs oligomerization of F1F0-ATP synthase  null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance
chrXI	471693	473349	471693	473349	-	YKR017C	YKR017C		471693,	473349,	Putative protein of unknown function  contains a RING finger motif
chrXI	473722	475900	473722	475900	-	YKR018C	YKR018C		473722,	475900,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
chrXI	476215	478063	476215	478063	-	IRS4	YKR019C		476215,	478063,	EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy  Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p  Irs4p and Tax4p are involved in localizing Atg17p to the PAS
chrXI	478337	478832	478337	478832	+	VPS51	YKR020W		478337,	478832,	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi  links the (VFT/GARP) complex to the SNARE Tlg1p
chrXI	479233	481981	479233	481981	+	ALY1	YKR021W		479233,	481981,	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p  interacts with AP-1 subunit Apl4p  may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets
chrXI	482170	483139	482170	483139	-	NTR2	YKR022C		482170,	483139,	Essential protein that forms a dimer with Ntr1p  also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
chrXI	483418	485011	483418	485011	+	YKR023W	YKR023W		483418,	485011,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXI	485143	487372	485143	487372	-	DBP7	YKR024C		485143,	487372,	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis  essential for growth under anaerobic conditions
chrXI	487769	488618	487769	488618	+	RPC37	YKR025W		487769,	488618,	RNA polymerase III subunit C37
chrXI	488737	489655	488737	489655	-	GCN3	YKR026C		488737,	489655,	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2  activity subsequently regulated by phosphorylated eIF2  first identified as a positive regulator of GCN4 expression
chrXI	491363	493661	491363	493661	+	BCH2	YKR027W		491363,	493661,	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
chrXI	494256	497358	494256	497358	+	SAP190	YKR028W		494256,	497358,	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function  member of a family of similar proteins including Sap4p, Sap155p, and Sap185p
chrXI	497577	499833	497577	499833	-	SET3	YKR029C		497577,	499833,	Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes  necessary for efficient transcription by RNAPII  one of two yeast proteins that contains both SET and PHD domains
chrXI	500281	501103	500281	501103	+	GMH1	YKR030W		500281,	501103,	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p  required for localization of Gea2p  computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
chrXI	501343	506395	501343	506395	-	SPO14	YKR031C		501343,	506395,	Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid  involved in Sec14p-independent secretion  required for meiosis and spore formation  differently regulated in secretion and meiosis
chrXI	506516	506831	506516	506831	+	YKR032W	YKR032W		506516,	506831,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXI	506878	507304	506878	507304	-	YKR033C	YKR033C		506878,	507304,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene DAL80
chrXI	506897	507707	506897	507707	+	DAL80	YKR034W		506897,	507707,	Negative regulator of genes in multiple nitrogen degradation pathways  expression is regulated by nitrogen levels and by Gln3p  member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
chrXI	507919	508561	507919	508561	-	OPI8	YKR035C		507919,	508561,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene DID2/YKR035W-A
chrXI	507938	508553	507938	508553	+	DID2	YKR035W-A		507938,	508553,	Class E protein of the vacuolar protein-sorting (Vps) pathway  binds Vps4p and directs it to dissociate ESCRT-III complexes  forms a functional and physical complex with Ist1p  human ortholog may be altered in breast tumors
chrXI	508701	510633	508701	510633	-	CAF4	YKR036C		508701,	510633,	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p  also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
chrXI	510909	511797	510909	511797	-	SPC34	YKR037C		510909,	511797,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  also localized to nuclear side of spindle pole body
chrXI	511998	513159	511998	513159	-	KAE1	YKR038C		511998,	513159,	Highly conserved ATPase of HSP70/DnaK family  component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p  EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
chrXI	515062	516871	515062	516871	+	GAP1	YKR039W		515062,	516871,	General amino acid permease  Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed
chrXI	518062	518566	518062	518566	-	YKR040C	YKR040C		518062,	518566,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YKR041W
chrXI	518197	518950	518197	518950	+	YKR041W	YKR041W		518197,	518950,	Protein of unknown function  localizes to the mitotic spindle  overexpression of YKR041W affects endocytic protein trafficking
chrXI	519526	520624	519526	520624	+	UTH1	YKR042W		519526,	520624,	Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy  involved in the oxidative stress response, life span during starvation, and cell death
chrXI	520896	521712	520896	521712	-	YKR043C	YKR043C		520896,	521712,	Sedoheptulose bisphosphatase involved in riboneogenesis  dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate  facilitates the conversion of glycolytic intermediates to pentose phosphate units  also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels  GFP-fusion protein localizes to the cytoplasm and nucleus
chrXI	522014	523346	522014	523346	+	UIP5	YKR044W		522014,	523346,	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
chrXI	523417	523969	523417	523969	-	YKR045C	YKR045C		523417,	523969,	Putative protein of unknown function  epitope-tagged protein localizes to the cytoplasm
chrXI	524222	525074	524222	525074	-	PET10	YKR046C		524222,	525074,	Protein of unknown function that co-purifies with lipid particles  expression pattern suggests a role in respiratory growth  computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
chrXI	525256	525562	525256	525562	+	YKR047W	YKR047W		525256,	525562,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene NAP1
chrXI	525386	526640	525386	526640	-	NAP1	YKR048C		525386,	526640,	Protein that interacts with mitotic cyclin Clb2p  required for the regulation of microtubule dynamics during mitosis  controls bud morphogenesis  involved in the transport of H2A and H2B histones to the nucleus  phosphorylated by CK2
chrXI	526829	527231	526829	527231	-	FMP46	YKR049C		526829,	527231,	Putative redox protein containing a thioredoxin fold  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXI	527814	530484	527814	530484	+	TRK2	YKR050W		527814,	530484,	Component of the Trk1p-Trk2p potassium transport system
chrXI	530945	532202	530945	532202	+	YKR051W	YKR051W		530945,	532202,	Putative protein of unknown function
chrXI	532549	533464	532549	533464	-	MRS4	YKR052C		532549,	533464,	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane  mitochondrial carrier family member, similar to and functionally redundant with Mrs3p  active under low-iron conditions  may transport other cations
chrXI	534066	535281	534066	535281	-	YSR3	YKR053C		534066,	535281,	Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism  has similarity to Lcb3p
chrXI	535646	547925	535646	547925	-	DYN1	YKR054C		535646,	547925,	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation  involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
chrXI	548215	549091	548215	549091	+	RHO4	YKR055W		548215,	549091,	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
chrXI	549447	551367	549447	551367	+	TRM2	YKR056W		549447,	551367,	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation  endo-exonuclease with a role in DNA repair
chrXI	551656	552242	551656	552242	+	RPS21A	YKR057W		551656,552002,	551680,552242,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein
chrXI	552769	554620	552769	554620	+	GLG1	YKR058W		552769,	554620,	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside  similar to mammalian glycogenin
chrXI	554986	556174	554986	556174	+	TIF1	YKR059W		554986,	556174,	Translation initiation factor eIF4A, identical to Tif2p  DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding  forms a dumbbell structure of two compact domains connected by a linker  interacts with eIF4G
chrXI	556517	557342	556517	557342	+	UTP30	YKR060W		556517,	557342,	Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
chrXI	557676	558954	557676	558954	+	KTR2	YKR061W		557676,	558954,	Mannosyltransferase involved in N-linked protein glycosylation  member of the KRE2/MNT1 mannosyltransferase family
chrXI	559665	560652	559665	560652	+	TFA2	YKR062W		559665,	560652,	TFIIE small subunit, involved in RNA polymerase II transcription initiation
chrXI	560788	562297	560788	562297	-	LAS1	YKR063C		560788,	562297,	Essential nuclear protein possibly involved in bud formation and morphogenesis  mutants require the SSD1-v allele for viability
chrXI	562546	565138	562546	565138	+	OAF3	YKR064W		562546,	565138,	Zinc cluster protein  regulates transcription in response to oleate levels  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXI	565298	565892	565298	565892	-	PAM17	YKR065C		565298,	565892,	Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex
chrXI	566112	567198	566112	567198	-	CCP1	YKR066C		566112,	567198,	Mitochondrial cytochrome-c peroxidase  degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
chrXI	567917	570149	567917	570149	+	GPT2	YKR067W		567917,	570149,	Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER  involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
chrXI	570327	570909	570327	570909	-	BET3	YKR068C		570327,	570909,	Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles  component of the TRAPP (transport protein particle) complex
chrXI	571611	573393	571611	573393	+	MET1	YKR069W		571611,	573393,	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase  required for sulfate assimilation and methionine biosynthesis
chrXI	573573	574632	573573	574632	+	YKR070W	YKR070W		573573,	574632,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXI	574933	575980	574933	575980	-	DRE2	YKR071C		574933,	575980,	Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery  contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p  ortholog of human Ciapin1
chrXI	576434	578123	576434	578123	-	SIS2	YKR072C		576434,	578123,	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC  Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
chrXI	578186	578507	578186	578507	-	YKR073C	YKR073C		578186,	578507,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXI	579208	579676	579208	579676	+	AIM29	YKR074W		579208,	579676,	Putative protein of unknown function  epitope-tagged protein localizes to the cytoplasm  YKR074W is not an essential gene  null mutant displays elevated frequency of mitochondrial genome loss
chrXI	579826	580750	579826	580750	-	YKR075C	YKR075C		579826,	580750,	Protein of unknown function  similar to YOR062Cp and Reg1p  expression regulated by glucose and Rgt1p  GFP-fusion protein is induced in response to the DNA-damaging agent MMS
chrXI	580211	580481	580211	580481	+	YKR075W-A	YKR075W-A		580211,	580481,	Dubious open reading frame unlikely to encode a protein  completely overlaps the uncharacterized gene YKR075W  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXI	582282	583395	582282	583395	+	ECM4	YKR076W		582282,	583395,	Omega class glutathione transferase  not essential  similar to Ygr154cp  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXI	583652	584744	583652	584744	+	MSA2	YKR077W		583652,	584744,	Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters  ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
chrXI	584951	586709	584951	586709	+	YKR078W	YKR078W		584951,	586709,	Cytoplasmic protein of unknown function, has similarity to Vps5p  potential Cdc28p substrate  contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
chrXI	586788	589305	586788	589305	-	TRZ1	YKR079C		586788,	589305,	tRNA 3'-end processing endonuclease tRNase Z  also localized to mitochondria and interacts genetically with Rex2 exonuclease  homolog of the human candidate prostate cancer susceptibility gene ELAC2
chrXI	590394	591357	590394	591357	+	MTD1	YKR080W		590394,	591357,	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units  expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
chrXI	591505	592540	591505	592540	-	RPF2	YKR081C		591505,	592540,	Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit  interacts with ribosomal protein L11  localizes predominantly to the nucleolus  constituent of 66S pre-ribosomal particles
chrXI	592824	596298	592824	596298	+	NUP133	YKR082W		592824,	596298,	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)  localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p  required also for transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
chrXI	596420	596822	596420	596822	-	DAD2	YKR083C		596420,	596822,	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation  is transferred to the kinetochore prior to mitosis
chrXI	597054	598890	597054	598890	-	HBS1	YKR084C		597054,	598890,	GTPase with similarity to translation release factors  together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled  genetically implicated in mRNA no-go decay
chrXI	599093	599681	599093	599681	-	MRPL20	YKR085C		599093,	599681,	Mitochondrial ribosomal protein of the large subunit
chrXI	599856	603072	599856	603072	+	PRP16	YKR086W		599856,	603072,	DEAH-box RNA helicase involved in second catalytic step of splicing  exhibits ATP-dependent RNA unwinding activity  mediates the release of Yju2p and Cwc25p in the second step  in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step
chrXI	603194	604232	603194	604232	-	OMA1	YKR087C		603194,	604232,	Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins  member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
chrXI	604404	605418	604404	605418	-	TVP38	YKR088C		604404,	605418,	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p  required for asymmetric localization of Kar9p during mitosis  GFP-fusion protein localizes to the cytoplasm in a punctate pattern
chrXI	605632	608365	605632	608365	-	TGL4	YKR089C		605632,	608365,	Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2  catalyzes acyl-CoA dependent acylation of LPA to PA  required with Tgl3p for timely bud formation  phosphorylated and activated by Cdc28p
chrXI	608945	611066	608945	611066	+	PXL1	YKR090W		608945,	611066,	LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p  has similarity to metazoan paxillin
chrXI	611524	612265	611524	612265	+	SRL3	YKR091W		611524,	612265,	Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation  potential Cdc28p substrate
chrXI	612664	613885	612664	613885	-	SRP40	YKR092C		612664,	613885,	Nucleolar, serine-rich protein with a role in preribosome assembly or transport  may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs)  immunologically and structurally to rat Nopp140
chrXI	615729	617535	615729	617535	+	PTR2	YKR093W		615729,	617535,	Integral membrane peptide transporter, mediates transport of di- and tri-peptides  conserved protein that contains 12 transmembrane domains  PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
chrXI	617995	618750	617995	618750	-	RPL40B	YKR094C		617995,618742,	618374,618750,	Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40  ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
chrXI	619804	625432	619804	625432	+	MLP1	YKR095W		619804,	625432,	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior  involved with Tel1p in telomere length control  involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
chrXI	625863	626205	625863	626205	+	PCC1	YKR095W-A		625863,625976,	625901,626205,	Component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p  EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
chrXI	626792	630380	626792	630380	+	YKR096W	YKR096W		626792,	630380,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm  predicted to contain a PINc domain
chrXI	631151	632801	631151	632801	+	PCK1	YKR097W		631151,	632801,	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
chrXI	633025	635179	633025	635179	-	UBP11	YKR098C		633025,	635179,	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
chrXI	635850	638286	635850	638286	+	BAS1	YKR099W		635850,	638286,	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways  also involved in regulation of meiotic recombination at specific genes
chrXI	638900	639968	638900	639968	-	SKG1	YKR100C		638900,	639968,	Transmembrane protein with a role in cell wall polymer composition  localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
chrXI	640539	642504	640539	642504	+	SIR1	YKR101W		640539,	642504,	Protein involved in repression of transcription at the silent mating-type loci HML and HMR  recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain  binds to centromeric chromatin
chrXI	646355	649865	646355	649865	+	FLO10	YKR102W		646355,	649865,	Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
chrXI	653079	656736	653079	656736	+	NFT1	YKR103W		653079,	656736,	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily  adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
chrXI	656835	657756	656835	657756	+	YKR104W	YKR104W		656835,	657756,	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily  contains a stop codon in S288C  adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
chrXI	658715	660464	658715	660464	-	VBA5	YKR105C		658715,	660464,	Putative transporter of the Major Facilitator Superfamily (MFS)  proposed role as a basic amino acid permease based on phylogeny
chrXI	661441	663289	661441	663289	+	YKR106W	YKR106W		661441,	663289,	Proton:glutathione antiporter localized to the vacuolar and plasma membranes  expressed at a very low level  almost identical to paralog Gex1p  potential role in resistance to oxidative stress and modulation of the PKA pathway
chrXII	584	4301	584	4301	-	YLL067C	YLL067C		584,4014,	3915,4301,	Putative protein of unknown function with similarity to helicases
chrXII	842	1325	842	1325	+	YLL067W-A	YLL067W-A		842,	1325,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps YLL067C
chrXII	5604	5775	5604	5775	+	YLL066W-B	YLL066W-B		5604,	5775,	Putative protein of unknown function  overexpression causes a cell cycle delay or arrest
chrXII	6119	9836	6119	9836	-	YLL066C	YLL066C		6119,9549,	9450,9836,	Putative protein of unknown function with similarity to helicases  YLL066C is not an essential gene
chrXII	6485	6968	6485	6968	+	YLL066W-A	YLL066W-A		6485,	6968,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the uncharacterized ORF YLL066C
chrXII	11725	12076	11725	12076	+	YLL065W	YLL065W		11725,	12076,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps chromosome XII telomeric element core sequences
chrXII	13082	13445	13082	13445	-	PAU18	YLL064C		13082,	13445,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions  identical to Pau6p
chrXII	14647	16072	14647	16072	-	AYT1	YLL063C		14647,	16072,	Acetyltransferase  catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
chrXII	16638	17613	16638	17613	-	MHT1	YLL062C		16638,	17613,	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
chrXII	17955	19707	17955	19707	+	MMP1	YLL061W		17955,	19707,	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source  has similarity to S-adenosylmethionine permease Sam3p
chrXII	21137	21839	21137	21839	-	GTT2	YLL060C		21137,	21839,	Glutathione S-transferase capable of homodimerization  functional overlap with Gtt2p, Grx1p, and Grx2p
chrXII	22473	22980	22473	22980	-	YLL059C	YLL059C		22473,	22980,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	23568	25296	23568	25296	+	YLL058W	YLL058W		23568,	25296,	Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism  YLL058W is not an essential gene
chrXII	25755	26994	25755	26994	-	JLP1	YLL057C		25755,	26994,	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source  contains sequence that resembles a J domain (typified by the E. coli DnaJ protein)  induced by sulphur starvation
chrXII	27408	28305	27408	28305	-	YLL056C	YLL056C		27408,	28305,	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR)  expression is induced in cells treated with the mycotoxin patulin
chrXII	30108	31704	30108	31704	+	YCT1	YLL055W		30108,	31704,	High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  YCT1 is not an essential gene
chrXII	32672	35204	32672	35204	-	YLL054C	YLL054C		32672,	35204,	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation  YLL054C is not an essential gene
chrXII	35502	35961	35502	35961	-	YLL053C	YLL053C		35502,	35961,	Putative protein  in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
chrXII	35911	36361	35911	36361	-	AQY2	YLL052C		35911,	36361,	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance  disrupted by a stop codon in many S. cerevisiae strains
chrXII	37332	39471	37332	39471	-	FRE6	YLL051C		37332,	39471,	Putative ferric reductase with similarity to Fre2p  expression induced by low iron levels
chrXII	39803	40414	39803	40414	-	COF1	YLL050C		39803,40400,	40221,40414,	Cofilin, promotes actin filament depolarization in a pH-dependent manner  binds both actin monomers and filaments and severs filaments  thought to be regulated by phosphorylation at SER4  ubiquitous and essential in eukaryotes
chrXII	40665	41205	40665	41205	+	LDB18	YLL049W		40665,	41205,	Component of the dynactin complex, which is required for dynein activity  null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye  has homology to mammalian dynactin subunit p24
chrXII	41279	46265	41279	46265	-	YBT1	YLL048C		41279,	46265,	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport  similar to mammalian bile transporters
chrXII	46671	47055	46671	47055	+	YLL047W	YLL047W		46671,	47055,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene RNP1
chrXII	46713	47463	46713	47463	-	RNP1	YLL046C		46713,	47463,	Ribonucleoprotein that contains two RNA recognition motifs (RRM)
chrXII	47858	48629	47858	48629	-	RPL8B	YLL045C		47858,	48629,	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein  mutation results in decreased amounts of free 60S subunits
chrXII	48215	48662	48215	48662	+	YLL044W	YLL044W		48215,	48662,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
chrXII	49937	51947	49937	51947	+	FPS1	YLL043W		49937,	51947,	Plasma membrane channel, member of major intrinsic protein (MIP) family  involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite  phosphorylated by Hog1p MAPK under acetate stress
chrXII	52086	52590	52086	52590	-	ATG10	YLL042C		52086,	52590,	Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
chrXII	53130	53931	53130	53931	-	SDH2	YLL041C		53130,	53931,	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
chrXII	54210	63645	54210	63645	-	VPS13	YLL040C		54210,	63645,	Protein of unknown function  heterooligomeric or homooligomeric complex  peripherally associated with membranes  homologous to human COH1  involved in sporulation, vacuolar protein sorting and protein-Golgi retention
chrXII	64061	65207	64061	65207	-	UBI4	YLL039C		64061,	65207,	Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system  essential for the cellular stress response  encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
chrXII	65774	66518	65774	66518	-	ENT4	YLL038C		65774,	66518,	Protein of unknown function, contains an N-terminal epsin-like domain  proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
chrXII	66561	66942	66561	66942	+	YLL037W	YLL037W		66561,	66942,	Dubious open reading frame unlikely to encode a functional protein  overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
chrXII	66744	68256	66744	68256	-	PRP19	YLL036C		66744,	68256,	Splicing factor associated with the spliceosome  contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
chrXII	68579	70478	68579	70478	+	GRC3	YLL035W		68579,	70478,	Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I  required for cell growth  mRNA is cell-cycle regulated
chrXII	70632	73146	70632	73146	-	RIX7	YLL034C		70632,	73146,	Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus  distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
chrXII	73408	74101	73408	74101	+	IRC19	YLL033W		73408,	74101,	Putative protein of unknown function  YLL033W is not an essential gene but mutant is defective in spore formation  null mutant displays increased levels of spontaneous Rad52p foci
chrXII	74269	76747	74269	76747	-	YLL032C	YLL032C		74269,	76747,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YLL032C is not an essential gene
chrXII	77151	80205	77151	80205	-	GPI13	YLL031C		77151,	80205,	ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor  similar to human PIG-O protein
chrXII	80355	80697	80355	80697	-	RRT7	YLL030C		80355,	80697,	Identified in a screen for mutants with increased levels of rDNA transcription  dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	81460	83710	81460	83710	+	FRA1	YLL029W		81460,	83710,	Protein involved in negative regulation of transcription of iron regulon  forms an iron independent complex with Fra2p, Grx3p, and Grx4p  cytosolic  mutant fails to repress transcription of iron regulon and is defective in spore formation
chrXII	84803	86564	84803	86564	+	TPO1	YLL028W		84803,	86564,	Polyamine transporter that recognizes spermine, putrescine, and spermidine  catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH  phosphorylation enhances activity and sorting to the plasma membrane
chrXII	87402	88155	87402	88155	+	ISA1	YLL027W		87402,	88155,	Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency  depletion reduces growth on nonfermentable carbon sources
chrXII	88622	91349	88622	91349	+	HSP104	YLL026W		88622,	91349,	Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins  responsive to stresses including: heat, ethanol, and sodium arsenite  involved in [PSI+] propagation
chrXII	94746	95121	94746	95121	+	PAU17	YLL025W		94746,	95121,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions  YLL025W is not an essential gene
chrXII	95565	97485	95565	97485	-	SSA2	YLL024C		95565,	97485,	ATP binding protein involved in protein folding and vacuolar import of proteins  member of heat shock protein 70 (HSP70) family  associated with the chaperonin-containing T-complex  present in the cytoplasm, vacuolar membrane and cell wall  98% identical with Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
chrXII	97996	98836	97996	98836	-	POM33	YLL023C		97996,	98836,	Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization  highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p
chrXII	99043	100201	99043	100201	-	HIF1	YLL022C		99043,	100201,	Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus  has a role in telomeric silencing
chrXII	100946	105347	100946	105347	+	SPA2	YLL021W		100946,	105347,	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth  acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components  potential Cdc28p substrate
chrXII	105555	105861	105555	105861	-	YLL020C	YLL020C		105555,	105861,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene KNS1
chrXII	105685	107899	105685	107899	-	KNS1	YLL019C		105685,	107899,	Nonessential putative protein kinase of unknown cellular role  member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
chrXII	106907	107000	106907	107000	+	YLL019W-A	YLL019W-A		106907,	107000,	Dubious open reading frame unlikely to encode a protein  completely overlaps the verified gene KNS1
chrXII	108675	108972	108675	108972	-	COX19	YLL018C-A		108675,	108972,	Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space  putative copper metallochaperone that delivers copper to cytochrome c oxidase  contains twin cysteine-x9-cysteine motifs
chrXII	109901	111575	109901	111575	-	DPS1	YLL018C		109901,	111575,	Aspartyl-tRNA synthetase, primarily cytoplasmic  homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp)  class II aminoacyl tRNA synthetase  binding to its own mRNA may confer autoregulation
chrXII	116431	121111	116431	121111	+	BPT1	YLL015W		116431,	121111,	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
chrXII	121321	121648	121321	121648	+	EMC6	YLL014W		121321,	121648,	Member of a transmembrane complex required for efficient folding of proteins in the ER  null mutant displays induction of the unfolded protein response
chrXII	122074	124714	122074	124714	-	PUF3	YLL013C		122074,	124714,	Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement  also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
chrXII	125533	127255	125533	127255	+	YEH1	YLL012W		125533,	127255,	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis  localized to lipid particle membranes
chrXII	127522	128992	127522	128992	+	SOF1	YLL011W		127522,	128992,	Essential protein required for biogenesis of 40S (small) ribosomal subunit  has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
chrXII	129329	130613	129329	130613	-	PSR1	YLL010C		129329,	130613,	Plasma membrane associated protein phosphatase involved in the general stress response  required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
chrXII	131204	131414	131204	131414	-	COX17	YLL009C		131204,	131414,	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase  contains twin cysteine-x9-cysteine motifs
chrXII	131728	133987	131728	133987	+	DRS1	YLL008W		131728,	133987,	Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits  constituent of 66S pre-ribosomal particles
chrXII	134301	136299	134301	136299	-	YLL007C	YLL007C		134301,	136299,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YLL007C is not an essential gene
chrXII	136344	136521	136344	136521	+	YLL006W-A	YLL006W-A		136344,	136521,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXII	136585	137866	136585	137866	+	MMM1	YLL006W		136585,	137866,	ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
chrXII	137939	140546	137939	140546	-	SPO75	YLL005C		137939,	140546,	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation  dispensable for both nuclear divisions during meiosis
chrXII	141072	142923	141072	142923	+	ORC3	YLL004W		141072,	142923,	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
chrXII	143200	146041	143200	146041	+	SFI1	YLL003W		143200,	146041,	Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C
chrXII	146290	147601	146290	147601	+	RTT109	YLL002W		146290,	147601,	Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase  acetylates H3-K56 and H3-K9  involved in non-homologous end joining and in regulation of Ty1 transposition  interacts physically with Vps75p
chrXII	147889	150163	147889	150163	+	DNM1	YLL001W		147889,	150163,	Dynamin-related GTPase required for mitochondrial fission and morphology  assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur  also participates in endocytosis and regulating peroxisome abundance
chrXII	151388	153977	151388	153977	-	YLR001C	YLR001C		151388,	153977,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  predicted to be palmitoylated
chrXII	154342	156334	154342	156334	-	NOC3	YLR002C		154342,	156334,	Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport  also binds to chromatin to promote the association of DNA replication factors and replication initiation
chrXII	156854	157730	156854	157730	-	CMS1	YLR003C		156854,	157730,	Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit  overexpression rescues supressor mutant of mcm10  null mutant is viable
chrXII	157933	159505	157933	159505	-	THI73	YLR004C		157933,	159505,	Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine  substrate of Dbf2p/Mob1p kinase  transcription is altered if mitochondrial dysfunction occurs
chrXII	160048	161434	160048	161434	+	SSL1	YLR005W		160048,	161434,	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair  interacts with Tfb4p
chrXII	161754	163893	161754	163893	-	SSK1	YLR006C		161754,	163893,	Cytoplasmic response regulator  part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism  required for mitophagy  dephosphorylated form is degraded by the ubiquitin-proteasome system  potential Cdc28p substrate
chrXII	164391	165402	164391	165402	+	NSE1	YLR007W		164391,	165402,	Essential subunit of the Mms21-Smc5-Smc6 complex  nuclear protein required for DNA repair and growth  has a nonstructural role in the maintenance of chromosomes
chrXII	165576	166083	165576	166083	-	PAM18	YLR008C		165576,	166083,	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import  inhibited by Pam16p
chrXII	166536	167136	166536	167136	+	RLP24	YLR009W		166536,	167136,	Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
chrXII	167319	167802	167319	167802	-	TEN1	YLR010C		167319,	167802,	Protein that regulates telomeric length  protects telomeric ends in a complex with Cdc13p and Stn1p
chrXII	169102	169678	169102	169678	+	LOT6	YLR011W		169102,	169678,	FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification  expression elevated at low temperature  sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
chrXII	169981	170281	169981	170281	-	YLR012C	YLR012C		169981,	170281,	Putative protein of unknown function  YLR012C is not an essential gene
chrXII	171338	171764	171338	171764	+	GAT3	YLR013W		171338,	171764,	Protein containing GATA family zinc finger motifs
chrXII	172267	174982	172267	174982	-	PPR1	YLR014C		172267,	174982,	Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis  activity may be modulated by interaction with Tup1p
chrXII	175226	176744	175226	176744	+	BRE2	YLR015W		175226,	176744,	Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres  has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p  similar to trithorax-group protein ASH2L
chrXII	176801	177416	176801	177416	-	PML1	YLR016C		176801,	177416,	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs  acts in the same pathway as Pml39p and Mlp1p
chrXII	177607	178621	177607	178621	+	MEU1	YLR017W		177607,	178621,	Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway  affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity  regulates ADH2 gene expression
chrXII	178706	179606	178706	179606	-	POM34	YLR018C		178706,	179606,	Integral membrane protein of the nuclear pore  has an important role in maintaining the architecture of the pore complex
chrXII	180287	181481	180287	181481	+	PSR2	YLR019W		180287,	181481,	Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response  required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
chrXII	181788	183405	181788	183405	-	YEH2	YLR020C		181788,	183405,	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane  involved in sterol metabolism
chrXII	183622	184162	183622	184162	+	IRC25	YLR021W		183622,	184162,	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome  may regulate formation of proteasome isoforms with alternative subunits under different conditions
chrXII	184173	184926	184173	184926	-	SDO1	YLR022C		184173,	184926,	Essential protein involved in 60S ribosome maturation  ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome  highly conserved across archae and eukaryotes
chrXII	185497	187129	185497	187129	-	IZH3	YLR023C		185497,	187129,	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency  deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
chrXII	187662	193281	187662	193281	-	UBR2	YLR024C		187662,	193281,	Cytoplasmic ubiquitin-protein ligase (E3)  required for ubiquitylation of Rpn4p  mediates formation of a Mub1p-Ubr2p-Rad6p complex
chrXII	194451	195174	194451	195174	+	SNF7	YLR025W		194451,	195174,	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III)  involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway  recruited from the cytoplasm to endosomal membranes
chrXII	195449	196472	195449	196472	-	SED5	YLR026C		195449,	196472,	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
chrXII	196828	198085	196828	198085	-	AAT2	YLR027C		196828,	198085,	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism  localizes to peroxisomes in oleate-grown cells
chrXII	199539	201315	199539	201315	-	ADE16	YLR028C		199539,	201315,	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p  ade16 ade17 mutants require adenine and histidine
chrXII	201975	202590	201975	202590	-	RPL15A	YLR029C		201975,	202590,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein  binds to 5.8 S rRNA
chrXII	203289	204081	203289	204081	+	YLR030W	YLR030W		203289,	204081,	Putative protein of unknown function
chrXII	204224	204785	204224	204785	+	YLR031W	YLR031W		204224,	204785,	Putative protein of unknown function
chrXII	204990	208500	204990	208500	+	RAD5	YLR032W		204990,	208500,	DNA helicase proposed to promote replication fork regression during postreplication repair by template switching  RING finger containing ubiquitin ligase  stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p
chrXII	208760	210269	208760	210269	+	RSC58	YLR033W		208760,	210269,	Component of the RSC chromatin remodeling complex  RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion  involved in telomere maintenance
chrXII	210511	211933	210511	211933	-	SMF3	YLR034C		210511,	211933,	Putative divalent metal ion transporter involved in iron homeostasis  transcriptionally regulated by metal ions  member of the Nramp family of metal transport proteins
chrXII	212368	214456	212368	214456	-	MLH2	YLR035C		212368,	214456,	Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination  forms a complex with Mlh1p
chrXII	215439	218907	215439	218907	-	YLR035C-A	YLR035C-A		215439,	218907,	Retrotransposon TYA Gag and TYB Pol genes  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  YLR035C-A is part of a mutant retrotransposon
chrXII	221520	222132	221520	222132	-	YLR036C	YLR036C		221520,	222132,	Putative protein of unknown function predicted to have transmembrane domains  interacts with HSP90 by yeast two-hybrid analysis  YLR036C is not an essential protein
chrXII	222684	223059	222684	223059	-	PAU23	YLR037C		222684,	223059,	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p  member of the seripauperin multigene family encoded mainly in subtelomeric regions  expressed under anaerobic conditions, completely repressed during aerobic growth
chrXII	224920	225172	224920	225172	-	COX12	YLR038C		224920,	225172,	Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  required for assembly of cytochrome c oxidase but not required for activity after assembly  phosphorylated
chrXII	225425	228596	225425	228596	-	RIC1	YLR039C		225425,	228596,	Protein involved in retrograde transport to the cis-Golgi network  forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p  involved in transcription of rRNA and ribosomal protein genes
chrXII	228907	229582	228907	229582	-	YLR040C	YLR040C		228907,	229582,	Putative protein of unknown function  localizes to the cell wall  predicted to be a GPI-attached protein  upregulated by Mcm1p-Alpha1p transcription factor  partially overlaps the dubious ORF YLR041W  YLR040C is not essential
chrXII	229376	229697	229376	229697	+	YLR041W	YLR041W		229376,	229697,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YLR040C
chrXII	229965	230451	229965	230451	-	YLR042C	YLR042C		229965,	230451,	Protein of unknown function  localizes to the cytoplasm  YLL042C is not an essential gene
chrXII	231701	232013	231701	232013	-	TRX1	YLR043C		231701,	232013,	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
chrXII	232389	234081	232389	234081	-	PDC1	YLR044C		232389,	234081,	Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde  subject to glucose-, ethanol-, and autoregulation  involved in amino acid catabolism
chrXII	235036	237703	235036	237703	-	STU2	YLR045C		235036,	237703,	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family  regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment  interacts with spindle pole body component Spc72p
chrXII	238000	238813	238000	238813	-	YLR046C	YLR046C		238000,	238813,	Putative membrane protein  member of the fungal lipid-translocating exporter (LTE) family of proteins  transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
chrXII	239346	241407	239346	241407	-	FRE8	YLR047C		239346,	241407,	Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis  deletion mutant has iron deficiency/accumulation growth defects  expression increased in the absence of copper-responsive transcription factor Mac1p
chrXII	242231	243349	242231	243349	+	RPS0B	YLR048W		242231,242680,	242321,243349,	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap  required for maturation of 18S rRNA along with Rps0Ap  deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
chrXII	243885	245172	243885	245172	-	YLR049C	YLR049C		243885,	245172,	Putative protein of unknown function
chrXII	245586	246072	245586	246072	-	YLR050C	YLR050C		245586,	246072,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  YLR050C is not an essential gene
chrXII	246323	246977	246323	246977	-	FCF2	YLR051C		246323,	246977,	Essential nucleolar protein involved in the early steps of 35S rRNA processing  interacts with Faf1p  member of a transcriptionally co-regulated set of genes called the RRB regulon
chrXII	247200	247953	247200	247953	+	IES3	YLR052W		247200,	247953,	Subunit of the INO80 chromatin remodeling complex
chrXII	248099	248426	248099	248426	-	YLR053C	YLR053C		248099,	248426,	Putative protein of unknown function
chrXII	248716	250978	248716	250978	-	OSW2	YLR054C		248716,250947,	250860,250978,	Protein of unknown function proposed to be involved in the assembly of the spore wall
chrXII	251271	253080	251271	253080	-	SPT8	YLR055C		251271,	253080,	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
chrXII	253860	254958	253860	254958	+	ERG3	YLR056W		253860,	254958,	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis  mutants are viable, but cannot grow on non-fermentable carbon sources
chrXII	255305	257855	255305	257855	+	YLR057W	YLR057W		255305,	257855,	Putative protein of unknown function  YLR050W is not an essential gene
chrXII	257991	259401	257991	259401	-	SHM2	YLR058C		257991,	259401,	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate  major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
chrXII	259737	260547	259737	260547	-	REX2	YLR059C		259737,	260547,	3'-5' RNA exonuclease  involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA  localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants  RNase D exonuclease
chrXII	260978	262766	260978	262766	+	FRS1	YLR060W		260978,	262766,	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme  able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
chrXII	263193	263948	263193	263948	+	RPL22A	YLR061W		263193,263594,	263205,263948,	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
chrXII	263576	263954	263576	263954	-	BUD28	YLR062C		263576,	263954,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  98% of ORF overlaps the verified gene RPL22A  diploid mutant displays a weak budding pattern phenotype in a systematic assay
chrXII	264156	265254	264156	265254	+	YLR063W	YLR063W		264156,	265254,	Putative S-adenosylmethionine-dependent methyltransferase  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YLR063W is not an essential gene
chrXII	265455	266277	265455	266277	+	PER33	YLR064W		265455,	266277,	Protein that localizes to the endoplasmic reticulum with some nuclear pore complex association  deletion extends chronological lifespan  highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p
chrXII	266372	266918	266372	266918	-	YLR065C	YLR065C		266372,	266918,	Putative protein of unknown function  YLR065C is not an essential gene
chrXII	267168	267723	267168	267723	+	SPC3	YLR066W		267168,	267723,	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway  homologous to mammalian SPC22/23
chrXII	267812	270710	267812	270710	-	PET309	YLR067C		267812,	270710,	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts  localizes to the mitochondrial inner membrane  contains seven pentatricopeptide repeats (PPRs)
chrXII	271007	271463	271007	271463	+	FYV7	YLR068W		271007,	271463,	Essential protein required for maturation of 18S rRNA  required for survival upon exposure to K1 killer toxin
chrXII	271629	273915	271629	273915	-	MEF1	YLR069C		271629,	273915,	Mitochondrial elongation factor involved in translational elongation
chrXII	274140	275211	274140	275211	-	XYL2	YLR070C		274140,	275211,	Xylitol dehydrogenase, converts xylitol to D-xylulose  expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae  null mutant has cell wall defect
chrXII	275377	278626	275377	278626	-	RGR1	YLR071C		275377,	278626,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  required for glucose repression, HO repression, RME1 repression and sporulation
chrXII	278861	280943	278861	280943	+	YLR072W	YLR072W		278861,	280943,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern  YLR072W is not an esssential gene
chrXII	281018	281621	281018	281621	-	RFU1	YLR073C		281018,	281621,	Protein that inhibits Doa4p deubiquitinating activity  contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p  GFP-fusion protein localizes to endosomes
chrXII	281955	282456	281955	282456	-	BUD20	YLR074C		281955,	282456,	Protein involved in bud-site selection  diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
chrXII	282926	283592	282926	283592	+	RPL10	YLR075W		282926,	283592,	Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits  regulates translation initiation  has similarity to rat L10 ribosomal protein and to members of the QM gene family
chrXII	283184	283607	283184	283607	-	YLR076C	YLR076C		283184,	283607,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
chrXII	283871	285623	283871	285623	+	FMP25	YLR077W		283871,	285623,	Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex)  mRNA is targeted to mitochondria
chrXII	285735	286559	285735	286559	-	BOS1	YLR078C		285735,286556,	286467,286559,	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
chrXII	286819	287674	286819	287674	+	SIC1	YLR079W		286819,	287674,	Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity  phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover  functional homolog of mammalian Kip1
chrXII	287915	289250	287915	289250	+	EMP46	YLR080W		287915,	289250,	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
chrXII	290211	291936	290211	291936	+	GAL2	YLR081W		290211,	291936,	Galactose permease, required for utilization of galactose  also able to transport glucose
chrXII	292393	293572	292393	293572	-	SRL2	YLR082C		292393,	293572,	Protein of unknown function  overexpression suppresses the lethality caused by a rad53 null mutation
chrXII	294090	296094	294090	296094	-	EMP70	YLR083C		294090,	296094,	Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting  similar to Tmn2p and Tmn3p  member of Transmembrane Nine family of proteins with 9 transmembrane segments
chrXII	296588	300251	296588	300251	-	RAX2	YLR084C		296588,	300251,	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding  localization requires Rax1p  RAX2 mRNA stability is regulated by Mpt5p
chrXII	300672	301989	300672	301989	-	ARP6	YLR085C		300672,	301989,	Actin-related protein that binds nucleosomes  a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
chrXII	302242	306499	302242	306499	+	SMC4	YLR086W		302242,	306499,	Subunit of the condensin complex  reorganizes chromosomes during cell division  forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity  required for tRNA gene clustering at the nucleolus  potential Cdc28p substrate
chrXII	306854	315731	306854	315731	-	CSF1	YLR087C		306854,	315731,	Protein required for fermentation at low temperature  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXII	316106	317951	316106	317951	+	GAA1	YLR088W		316106,	317951,	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
chrXII	318236	320015	318236	320015	-	ALT1	YLR089C		318236,	320015,	Alanine transaminase (glutamic pyruvic transaminase)  involved in alanine biosynthetic and catabolic processes  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXII	320700	322080	320700	322080	+	XDJ1	YLR090W		320700,	322080,	Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXII	322296	323178	322296	323178	+	GEP5	YLR091W		322296,	323178,	Protein of unknown function, required for mitochondrial genome maintenance  detected in highly purified mitochondria in high-throughput studies  null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
chrXII	323543	326225	323543	326225	+	SUL2	YLR092W		323543,	326225,	High affinity sulfate permease  sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
chrXII	326512	327415	326512	327415	-	NYV1	YLR093C		326512,327399,	327258,327415,	v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion  inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
chrXII	327729	329238	327729	329238	-	GIS3	YLR094C		327729,	329238,	Protein of unknown function
chrXII	329676	332115	329676	332115	-	IOC2	YLR095C		329676,	332115,	Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
chrXII	332589	336033	332589	336033	+	KIN2	YLR096W		332589,	336033,	Serine/threonine protein kinase involved in regulation of exocytosis  localizes to the cytoplasmic face of the plasma membrane  closely related to Kin1p
chrXII	336230	337265	336230	337265	-	HRT3	YLR097C		336230,	337265,	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity  identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
chrXII	337526	339473	337526	339473	-	CHA4	YLR098C		337526,	339473,	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1)  Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
chrXII	339743	340928	339743	340928	-	ICT1	YLR099C		339743,	340928,	Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress  null displays increased sensitivity to Calcofluor white  highly expressed during organic solvent stress
chrXII	341324	341588	341324	341588	+	YLR099W-A	YLR099W-A		341324,	341588,	Putative protein of unknown function
chrXII	341809	342853	341809	342853	+	ERG27	YLR100W		341809,	342853,	3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis  mutants are sterol auxotrophs
chrXII	342565	342961	342565	342961	-	YLR101C	YLR101C		342565,	342961,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified, essential ORF ERG27/YLR100W
chrXII	342969	343767	342969	343767	-	APC9	YLR102C		342969,	343767,	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
chrXII	343988	345941	343988	345941	-	CDC45	YLR103C		343988,	345941,	DNA replication initiation factor  recruited to MCM pre-RC complexes at replication origins  promotes release of MCM from Mcm10p, recruits elongation machinery  mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
chrXII	346584	346980	346584	346980	+	LCL2	YLR104W		346584,	346980,	Putative protein of unknown function  mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan  genetic interactions suggest a role in ER-associated protein degradation (ERAD)
chrXII	347046	348180	347046	348180	-	SEN2	YLR105C		347046,	348180,	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p  Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
chrXII	349005	363738	349005	363738	-	MDN1	YLR106C		349005,	363738,	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p)  acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
chrXII	364115	365330	364115	365330	+	REX3	YLR107W		364115,	365330,	RNA exonuclease  required for maturation of the RNA component of RNase MRP  functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA  member of RNase D family of exonucleases
chrXII	366666	368124	366666	368124	-	YLR108C	YLR108C		366666,	368124,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus  YLR108C is not an esssential gene
chrXII	368780	369311	368780	369311	+	AHP1	YLR109W		368780,	369311,	Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage  function in vivo requires covalent conjugation to Urm1p
chrXII	369696	370098	369696	370098	-	CCW12	YLR110C		369696,	370098,	Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall  localizes to periphery of small buds, septum region of larger buds, and shmoo tip
chrXII	370390	370723	370390	370723	+	YLR111W	YLR111W		370390,	370723,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	370790	371210	370790	371210	+	YLR112W	YLR112W		370790,	371210,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	371619	372927	371619	372927	+	HOG1	YLR113W		371619,	372927,	Mitogen-activated protein kinase involved in osmoregulation  acts via three independent osmosensors  mitophagy-specific regulator  mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters  localization regulated by Ptp2p and Ptp3p
chrXII	374943	377238	374943	377238	-	AVL9	YLR114C		374943,	377238,	Conserved protein involved in exocytic transport from the Golgi  mutation is synthetically lethal with apl2 vps1 double mutation  member of a protein superfamily with orthologs in diverse organisms
chrXII	377984	380564	377984	380564	+	CFT2	YLR115W		377984,	380564,	Subunit of the mRNA cleavage and polyadenlylation factor (CPF)  required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
chrXII	380821	382252	380821	382252	+	MSL5	YLR116W		380821,	382252,	Component of the commitment complex, which defines the first step in the splicing pathway  essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends  also involved in nuclear retention of pre-mRNA
chrXII	382470	384534	382470	384534	-	CLF1	YLR117C		382470,	384534,	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs  homolog of Drosophila crooked neck protein  interacts with U1 snRNP proteins
chrXII	384724	385408	384724	385408	-	YLR118C	YLR118C		384724,	385408,	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
chrXII	385533	386175	385533	386175	+	SRN2	YLR119W		385533,	386175,	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome  suppressor of rna1-1 mutation  may be involved in RNA export from nucleus
chrXII	386510	388220	386510	388220	-	YPS1	YLR120C		386510,	388220,	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance  attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
chrXII	388671	388773	388671	388773	+	YLR120W-A	YLR120W-A		388671,	388773,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the verified ORF YLR121C
chrXII	388743	390270	388743	390270	-	YPS3	YLR121C		388743,	390270,	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance  attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
chrXII	390953	391331	390953	391331	-	YLR122C	YLR122C		390953,	391331,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YLR123C
chrXII	391077	391407	391077	391407	-	YLR123C	YLR123C		391077,	391407,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YLR122C  contains characteristic aminoacyl-tRNA motif
chrXII	391599	391944	391599	391944	+	YLR124W	YLR124W		391599,	391944,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	393483	393894	393483	393894	+	YLR125W	YLR125W		393483,	393894,	Putative protein of unknown function  mutant has decreased Ty3 transposition  YLR125W is not an essential gene
chrXII	394764	395520	394764	395520	-	YLR126C	YLR126C		394764,	395520,	Putative protein of unknown function with similarity to glutamine amidotransferase proteins  has Aft1p-binding motif in the promoter  may be involved in copper and iron homeostasis  YLR126C is not an essential protein
chrXII	395757	398319	395757	398319	-	APC2	YLR127C		395757,	398319,	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition  component of the catalytic core of the APC/C  has similarity to cullin Cdc53p
chrXII	398529	399433	398529	399433	+	DCN1	YLR128W		398529,398626,	398532,399433,	Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation  contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
chrXII	399656	402488	399656	402488	+	DIP2	YLR129W		399656,	402488,	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
chrXII	402793	404062	402793	404062	-	ZRT2	YLR130C		402793,	404062,	Low-affinity zinc transporter of the plasma membrane  transcription is induced under low-zinc conditions by the Zap1p transcription factor
chrXII	404509	406822	404509	406822	-	ACE2	YLR131C		404509,	406822,	Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation
chrXII	407282	408155	407282	408155	-	YLR132C	YLR132C		407282,	408155,	Essential protein of unknown function  fluorescent protein (GFP or YFP)-tagged protein localizes to mitochondria, cytoplasm and nucleus
chrXII	408444	410193	408444	410193	+	CKI1	YLR133W		408444,	410193,	Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway)  exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
chrXII	410722	412414	410722	412414	+	PDC5	YLR134W		410722,	412414,	Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
chrXII	413280	415527	413280	415527	+	SLX4	YLR135W		413280,	415527,	Endonuclease involved in processing DNA during recombination and repair  cleaves branched structures in a complex with Slx1p  involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing
chrXII	415800	416658	415800	416658	-	TIS11	YLR136C		415800,	416658,	mRNA-binding protein expressed during iron starvation  binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation  involved in iron homeostasis
chrXII	417005	418109	417005	418109	+	YLR137W	YLR137W		417005,	418109,	Protein lysine methyltransferase  monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b  member of the seven beta-strand methyltransferase superfamily  orthologs only found among fungal species
chrXII	418436	421394	418436	421394	+	NHA1	YLR138W		418436,	421394,	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane  required for alkali cation tolerance at acidic pH
chrXII	421541	423473	421541	423473	-	SLS1	YLR139C		421541,	423473,	Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes  may facilitate delivery of mRNA to membrane-bound translation machinery
chrXII	423473	423800	423473	423800	+	YLR140W	YLR140W		423473,	423800,	Dubious open reading frame unlikely to encode a functional protein  overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
chrXII	423682	424774	423682	424774	+	RRN5	YLR141W		423682,	424774,	Protein involved in transcription of rDNA by RNA polymerase I  transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
chrXII	425185	426616	425185	426616	+	PUT1	YLR142W		425185,	426616,	Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source  PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
chrXII	427328	429386	427328	429386	+	YLR143W	YLR143W		427328,	429386,	Putative protein of unknown function  green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm  YLR143W is not an essential gene
chrXII	429676	432016	429676	432016	-	ACF2	YLR144C		429676,	432016,	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation  may have a role in cortical actin cytoskeleton assembly
chrXII	432167	432773	432167	432773	+	RMP1	YLR145W		432167,	432773,	Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs  unlike most subunits, not shared between RNase MRP and nuclear RNase P
chrXII	432822	433725	432822	433725	-	SPE4	YLR146C		432822,	433725,	Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
chrXII	433869	434058	433869	434058	+	YLR146W-A	YLR146W-A		433869,	434058,	Putative protein of unknown function
chrXII	434157	434463	434157	434463	-	SMD3	YLR147C		434157,	434463,	Core Sm protein Sm D3  part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs  homolog of human Sm D3
chrXII	434640	437397	434640	437397	+	PEP3	YLR148W		434640,	437397,	Component of CORVET tethering complex  vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
chrXII	437630	439823	437630	439823	-	YLR149C	YLR149C		437630,	439823,	Putative protein of unknown function  overexpression causes a cell cycle delay or arrest  null mutation results in a decrease in plasma membrane electron transport  YLR149C is not an essential gene
chrXII	440369	440456	440369	440456	-	YLR149C-A	YLR149C-A		440369,	440456,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	440466	441288	440466	441288	+	STM1	YLR150W		440466,	441288,	Protein required for optimal translation under nutrient stress  perturbs association of Yef3p with ribosomes  involved in TOR signaling  binds G4 quadruplex and purine motif triplex nucleic acid  helps maintain telomere structure
chrXII	441714	442737	441714	442737	-	PCD1	YLR151C		441714,	442737,	Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids
chrXII	442957	444688	442957	444688	-	YLR152C	YLR152C		442957,	444688,	Putative protein of unknown function  YLR152C is not an essential gene
chrXII	445523	447575	445523	447575	-	ACS2	YLR153C		445523,	447575,	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation  mutants affect global transcription  required for growth on glucose  expressed under anaerobic conditions
chrXII	447981	448314	447981	448314	-	RNH203	YLR154C		447981,	448314,	Ribonuclease H2 subunit, required for RNase H2 activity  related to human AGS3 that causes Aicardi-Goutieres syndrome
chrXII	452437	452623	452437	452623	+	YLR154W-A	YLR154W-A		452437,	452623,	Dubious open reading frame unlikely to encode a protein  encoded within the the 25S rRNA gene on the opposite strand
chrXII	454391	454556	454391	454556	+	YLR154W-B	YLR154W-B		454391,	454556,	Dubious open reading frame unlikely to encode a protein  encoded within the the 25S rRNA gene on the opposite strand
chrXII	454695	455070	454695	455070	+	TAR1	YLR154W-C		454695,	455070,	Mitochondrial protein potentially involved in regulation of respiratory metabolism  interacts genetically with RPO41 and physically with Coq5p  encoded within the 25S rRNA gene on the opposite strand
chrXII	455432	455636	455432	455636	+	YLR154W-E	YLR154W-E		455432,	455636,	Dubious open reading frame unlikely to encode a protein  encoded within the the 35S rRNA gene on the opposite strand
chrXII	455882	456023	455882	456023	+	YLR154W-F	YLR154W-F		455882,	456023,	Dubious open reading frame unlikely to encode a protein  encoded within the the 35S rRNA gene on the opposite strand
chrXII	462521	462671	462521	462671	-	YLR154C-G	YLR154C-G		462521,	462671,	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR  this ORF is contained within RDN25-2 and RDN37-2
chrXII	468826	468958	468826	468958	-	YLR154C-H	YLR154C-H		468826,	468958,	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR  this ORF partially overlaps RND5-2
chrXII	469316	470405	469316	470405	-	ASP3-1	YLR155C		469316,	470405,	Cell-wall L-asparaginase II involved in asparagine catabolism  expression induced during nitrogen starvation  ORF contains a short non-coding RNA that enhances expression of full-length gene  reference strain S288C has four copies of ASP3
chrXII	472112	472457	472112	472457	+	YLR156W	YLR156W		472112,	472457,	Putative protein of unknown function  exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis
chrXII	472478	472610	472478	472610	-	YLR156C-A	YLR156C-A		472478,	472610,	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR  this ORF partially overlaps RND5-3
chrXII	472968	474057	472968	474057	-	ASP3-2	YLR157C		472968,	474057,	Cell-wall L-asparaginase II involved in asparagine catabolism  expression induced during nitrogen starvation  ORF contains a short non-coding RNA that enhances expression of full-length gene  reference strain S288C has four copies of ASP3
chrXII	475763	475976	475763	475976	+	YLR157W-D	YLR157W-D		475763,	475976,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXII	476332	481601	476332	481601	-	YLR157C-B	YLR157C-B		476332,480296,	480295,481601,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXII	480278	481601	480278	481601	-	YLR157C-A	YLR157C-A		480278,	481601,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXII	481872	482037	481872	482037	+	YLR157W-E	YLR157W-E		481872,	482037,	Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching  partially overlaps a Ty1 element
chrXII	482058	482190	482058	482190	-	YLR157C-C	YLR157C-C		482058,	482190,	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR  this ORF partially overlaps RND5-4
chrXII	482548	483637	482548	483637	-	ASP3-3	YLR158C		482548,	483637,	Cell-wall L-asparaginase II involved in asparagine catabolism  expression induced during nitrogen starvation  ORF contains a short non-coding RNA that enhances expression of full-length gene  reference strain S288C has four copies of ASP3
chrXII	485344	485689	485344	485689	+	YLR159W	YLR159W		485344,	485689,	Putative protein of unknown function  YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12
chrXII	485710	485842	485710	485842	-	YLR159C-A	YLR159C-A		485710,	485842,	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR  this ORF partially overlaps RND5-5
chrXII	486200	487289	486200	487289	-	ASP3-4	YLR160C		486200,	487289,	Cell-wall L-asparaginase II involved in asparagine catabolism  expression induced during nitrogen starvation  ORF contains a short non-coding RNA that enhances expression of full-length gene  reference strain S288C has four copies of ASP3
chrXII	488996	489341	488996	489341	+	YLR161W	YLR161W		488996,	489341,	Putative protein of unknown function  YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12
chrXII	489572	489929	489572	489929	+	YLR162W	YLR162W		489572,	489929,	Putative protein of unknown function  overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride
chrXII	490405	490594	490405	490594	+	RRT15	YLR162W-A		490405,	490594,	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR  identified in a screen for mutants with decreased levels of rDNA transcription
chrXII	491865	493254	491865	493254	-	MAS1	YLR163C		491865,	493254,	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
chrXII	492811	492925	492811	492925	+	YLR163W-A	YLR163W-A		492811,	492925,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
chrXII	493882	494389	493882	494389	+	YLR164W	YLR164W		493882,	494389,	Mitochondrial inner membrane protein of unknown function  similar to Tim18p and Sdh4p  expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
chrXII	494493	495258	494493	495258	-	PUS5	YLR165C		494493,	495258,	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA  not essential for viability
chrXII	495428	498044	495428	498044	-	SEC10	YLR166C		495428,	498044,	Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
chrXII	498946	499405	498946	499405	+	RPS31	YLR167W		498946,	499405,	Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin  ubiquitin may facilitate assembly of the ribosomal protein into ribosomes  interacts genetically with translation factor eIF2B
chrXII	499577	500270	499577	500270	-	UPS2	YLR168C		499577,	500270,	Mitochondrial intermembrane space protein involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels  null has defects in mitochondrial morphology  similar to Ups1p, Ups3p and to human PRELI
chrXII	500334	500688	500334	500688	+	YLR169W	YLR169W		500334,	500688,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	500578	501049	500578	501049	-	APS1	YLR170C		500578,	501049,	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network  homolog of the sigma subunit of the mammalian clathrin AP-1 complex
chrXII	500732	501122	500732	501122	+	YLR171W	YLR171W		500732,	501122,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	501259	502162	501259	502162	-	DPH5	YLR172C		501259,	502162,	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p)  not essential for viability  GFP-Dph5p fusion protein localizes to the cytoplasm
chrXII	502420	504247	502420	504247	+	YLR173W	YLR173W		502420,	504247,	Putative protein of unknown function
chrXII	504590	505829	504590	505829	+	IDP2	YLR174W		504590,	505829,	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate  levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
chrXII	506133	507585	506133	507585	+	CBF5	YLR175W		506133,	507585,	Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2  mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
chrXII	507796	510232	507796	510232	-	RFX1	YLR176C		507796,	510232,	Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters  involved in DNA damage and replication checkpoint pathway  similar to a family of mammalian DNA binding RFX1-4 proteins
chrXII	511053	512940	511053	512940	+	YLR177W	YLR177W		511053,	512940,	Putative protein of unknown function  phosphorylated by Dbf2p-Mob1p in vitro  some strains contain microsatellite polymophisms at this locus  YLR177W is not an essential gene
chrXII	513161	513821	513161	513821	-	TFS1	YLR178C		513161,	513821,	Protein that interacts with and inhibits carboxypeptidase Y and Ira2p  phosphatidylethanolamine-binding protein (PEBP) family member  targets to vacuolar membranes during stationary phase  acetylated by NatB N-terminal acetyltransferase
chrXII	514107	514713	514107	514713	-	YLR179C	YLR179C		514107,	514713,	Protein of unknown function with similarity to Tfs1p  transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance  GFP-tagged protein localizes to the cytoplasm and nucleus
chrXII	515261	516410	515261	516410	+	SAM1	YLR180W		515261,	516410,	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine  one of two differentially regulated isozymes (Sam1p and Sam2p)
chrXII	516677	517670	516677	517670	-	VTA1	YLR181C		516677,	517670,	Multivesicular body (MVB) protein involved in endosomal protein sorting  regulates Vps4p activity by promoting its oligomerization  has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain
chrXII	517939	520351	517939	520351	+	SWI6	YLR182W		517939,	520351,	Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition  involved in meiotic gene expression  cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization
chrXII	520542	522012	520542	522012	-	TOS4	YLR183C		520542,	522012,	Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin  target of SBF transcription factor  expression is periodic and peaks in G1  similar to PLM2
chrXII	522105	522453	522105	522453	+	YLR184W	YLR184W		522105,	522453,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	522662	523288	522662	523288	+	RPL37A	YLR185W		522662,523028,	522669,523288,	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
chrXII	523631	524390	523631	524390	+	EMG1	YLR186W		523631,	524390,	Member of the alpha/beta knot fold methyltransferase superfamily  required for maturation of 18S rRNA and for 40S ribosome production  interacts with RNA and with S-adenosylmethionine  associates with spindle/microtubules  forms homodimers
chrXII	524864	527945	524864	527945	+	SKG3	YLR187W		524864,	527945,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck  potential Cdc28p substrate  similar to Caf120p and Skg4p
chrXII	528299	530387	528299	530387	+	MDL1	YLR188W		528299,	530387,	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
chrXII	530796	534393	530796	534393	-	ATG26	YLR189C		530796,	534393,	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids  in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
chrXII	535213	536689	535213	536689	+	MMR1	YLR190W		535213,	536689,	Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud  interacts with Myo2p to mediate mitochondrial distribution to buds  mRNA is targeted to the bud via the transport system involving She2p
chrXII	537271	538432	537271	538432	+	PEX13	YLR191W		537271,	538432,	Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
chrXII	538791	539589	538791	539589	-	HCR1	YLR192C		538791,	539589,	Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA  binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
chrXII	540008	540536	540008	540536	-	UPS1	YLR193C		540008,	540536,	Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology  ortholog of human PRELI
chrXII	540808	541573	540808	541573	-	YLR194C	YLR194C		540808,	541573,	Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor  expression is upregulated in response to cell wall stress
chrXII	541936	543304	541936	543304	-	NMT1	YLR195C		541936,	543304,	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
chrXII	543967	545698	543967	545698	+	PWP1	YLR196W		543967,	545698,	Protein with WD-40 repeats involved in rRNA processing  associates with trans-acting ribosome biogenesis factors  similar to beta-transducin superfamily
chrXII	546096	547611	546096	547611	+	NOP56	YLR197W		546096,	547611,	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation  overexpression causes spindle orientation defects
chrXII	547285	547645	547285	547645	-	YLR198C	YLR198C		547285,	547645,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene SIK1/YLR197W
chrXII	547852	548769	547852	548769	-	PBA1	YLR199C		547852,548763,	548677,548769,	Protein involved in 20S proteasome assembly  forms a heterodimer with Add66p that binds to proteasome precursors  similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
chrXII	549011	549356	549011	549356	+	YKE2	YLR200W		549011,	549356,	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
chrXII	549510	550293	549510	550293	-	COQ9	YLR201C		549510,	550293,	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth  localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
chrXII	550193	550636	550193	550636	-	YLR202C	YLR202C		550193,550574,	550458,550636,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YLR201C  ORF contains a putative intron
chrXII	550649	551960	550649	551960	-	MSS51	YLR203C		550649,	551960,	Specific translational activator for the mitochondrial COX1 mRNA  loosely associated with the matrix face of the mitochondrial inner membrane  influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase
chrXII	552269	552605	552269	552605	+	QRI5	YLR204W		552269,	552605,	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA  may have an additional role in translation of COX1 mRNA
chrXII	552723	553677	552723	553677	-	HMX1	YLR205C		552723,	553677,	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response  expression is regulated by AFT1 and oxidative stress  relocates to the perinuclear region in the presence of oxidants
chrXII	554577	556419	554577	556419	+	ENT2	YLR206W		554577,	556419,	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p  contains clathrin-binding motif at C-terminus
chrXII	556787	559289	556787	559289	+	HRD3	YLR207W		556787,	559289,	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
chrXII	559550	560444	559550	560444	+	SEC13	YLR208W		559550,	560444,	Component of the Nup84 nuclear pore sub-complex, the Sec13p-Sec31p complex of the COPII vesicle coat, and the SEA (Seh1-associated) complex  required for vesicle formation in ER to Golgi transport and nuclear pore complex organization  the Nup84 subcomplex has a role in transcription elongation
chrXII	560796	561732	560796	561732	-	PNP1	YLR209C		560796,	561732,	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides  involved in the nicotinamide riboside salvage pathway
chrXII	562007	563390	562007	563390	+	CLB4	YLR210W		562007,	563390,	B-type cyclin involved in cell cycle progression  activates Cdc28p to promote the G2/M transition  may be involved in DNA replication and spindle assembly  accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
chrXII	563791	564531	563791	564531	-	YLR211C	YLR211C		563791,564513,	564454,564531,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YLR211C is not an essential gene  ORF contains an intron
chrXII	564859	566281	564859	566281	-	TUB4	YLR212C		564859,	566281,	Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
chrXII	566653	567922	566653	567922	-	CRR1	YLR213C		566653,	567922,	Putative glycoside hydrolase of the spore wall envelope  required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers  expressed during sporulation
chrXII	568566	570627	568566	570627	+	FRE1	YLR214W		568566,	570627,	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters  expression induced by low copper and iron levels
chrXII	570775	571858	570775	571858	-	CDC123	YLR215C		570775,	571858,	Protein involved in nutritional control of the cell cycle  regulates abundance of the translation initiation factor eIF2  ortholog of human D123 protein
chrXII	572095	573211	572095	573211	-	CPR6	YLR216C		572095,	573211,	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  binds to Hsp82p and contributes to chaperone activity
chrXII	572908	573232	572908	573232	+	YLR217W	YLR217W		572908,	573232,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene CPR6
chrXII	573465	573918	573465	573918	-	COA4	YLR218C		573465,	573918,	Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability  localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system  interacts genetically with CYC1 and with cytochrome c oxidase assembly factors
chrXII	574150	576337	574150	576337	+	MSC3	YLR219W		574150,	576337,	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery  msc3 mutants are defective in directing meiotic recombination events to homologous chromatids  potential Cdc28p substrate
chrXII	576824	577793	576824	577793	+	CCC1	YLR220W		576824,	577793,	Putative vacuolar Fe2+/Mn2+ transporter  suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation
chrXII	578361	579024	578361	579024	-	RSA3	YLR221C		578361,	579024,	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits  binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
chrXII	579317	581771	579317	581771	-	UTP13	YLR222C		579317,	581771,	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
chrXII	582005	582236	582005	582236	-	YLR222C-A	YLR222C-A		582005,	582236,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene IFH1
chrXII	582232	585490	582232	585490	-	IFH1	YLR223C		582232,	585490,	Coactivator that regulates transcription of ribosomal protein (RP) genes  recruited to RP gene promoters during optimal growth conditions via Fhl1p  subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
chrXII	586463	587573	586463	587573	+	YLR224W	YLR224W		586463,	587573,	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism  readily monoubiquitinated in vitro by SCF-Ubc4 complexes  YLR224W is not an essential gene
chrXII	587694	588918	587694	588918	-	YLR225C	YLR225C		587694,	588918,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YLR225C is not an essential gene
chrXII	589353	590541	589353	590541	+	BUR2	YLR226W		589353,	590541,	Cyclin for the Sgv1p (Bur1p) protein kinase  Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
chrXII	590561	592043	590561	592043	-	ADY4	YLR227C		590561,	592043,	Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
chrXII	593437	598706	593437	598706	+	YLR227W-B	YLR227W-B		593437,594743,	594742,598706,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXII	593437	594760	593437	594760	+	YLR227W-A	YLR227W-A		593437,	594760,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXII	600018	602463	600018	602463	-	ECM22	YLR228C		600018,	602463,	Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes  contains Zn[2]-Cys[6] binuclear cluster  homologous to Upc2p  relocates from intracellular membranes to perinuclear foci on sterol depletion
chrXII	604211	604787	604211	604787	-	CDC42	YLR229C		604211,	604787,	Small rho-like GTPase, essential for establishment and maintenance of cell polarity  mutants have defects in the organization of actin and septins
chrXII	604573	604879	604573	604879	+	YLR230W	YLR230W		604573,	604879,	Dubious open reading frame unlikely to encode a functional protein  overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
chrXII	605757	607119	605757	607119	-	BNA5	YLR231C		605757,	607119,	Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine  expression regulated by Hst1p
chrXII	606829	607177	606829	607177	+	YLR232W	YLR232W		606829,	607177,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene BNA5
chrXII	607424	609524	607424	609524	-	EST1	YLR233C		607424,	609524,	TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase  has G-quadruplex promoting activity that is required for telomere elongation  possible role in activating telomere-bound Est2p-TLC1-RNA
chrXII	609782	611753	609782	611753	+	TOP3	YLR234W		609782,	611753,	DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
chrXII	611531	611930	611531	611930	-	YLR235C	YLR235C		611531,	611930,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene TOP3
chrXII	611793	612117	611793	612117	-	YLR236C	YLR236C		611793,	612117,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	612366	614163	612366	614163	+	THI7	YLR237W		612366,	614163,	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters  mutation of human ortholog causes thiamine-responsive megaloblastic anemia
chrXII	614754	616191	614754	616191	+	FAR10	YLR238W		614754,	616191,	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway  interacts with Far3p, Far7p, Far8p, Far9p, and Far11p  potential Cdc28p substrate
chrXII	616331	617318	616331	617318	-	LIP2	YLR239C		616331,	617318,	Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
chrXII	617532	620160	617532	620160	+	VPS34	YLR240W		617532,	620160,	Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate  forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting  activated by the GTP-bound form of Gpa1p
chrXII	620472	622821	620472	622821	+	YLR241W	YLR241W		620472,	622821,	Putative protein of unknown function, may be involved in detoxification
chrXII	622917	623883	622917	623883	-	ARV1	YLR242C		622917,	623883,	Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen  required for normal intracellular sterol distribution  human ARV1 required for normal cholesterol and bile acid homeostasis  similar to Nup120p
chrXII	624202	625021	624202	625021	+	YLR243W	YLR243W		624202,	625021,	Putative protein of unknown function  YLR243W is an essential gene
chrXII	625167	626331	625167	626331	-	MAP1	YLR244C		625167,	626331,	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides  function is partially redundant with that of Map2p
chrXII	626501	626930	626501	626930	-	CDD1	YLR245C		626501,	626930,	Cytidine deaminase  catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm
chrXII	627117	628197	627117	628197	+	ERF2	YLR246W		627117,	628197,	Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage  mutants partially mislocalize Ras2p to the vacuole
chrXII	628683	633354	628683	633354	-	IRC20	YLR247C		628683,	633354,	Putative helicase  localizes to the mitochondrion and the nucleus  YLR247C is not an essential gene  null mutant displays increased levels of spontaneous Rad52p foci
chrXII	634251	636084	634251	636084	+	RCK2	YLR248W		634251,	636084,	Protein kinase involved in the response to oxidative and osmotic stress  identified as suppressor of S. pombe cell cycle checkpoint mutations  similar to CaM (calmodulin) kinases
chrXII	636779	639914	636779	639914	+	YEF3	YLR249W		636779,	639914,	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex  contains two ABC cassettes  binds and hydrolyzes ATP
chrXII	640316	641021	640316	641021	+	SSP120	YLR250W		640316,	641021,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrXII	641463	642057	641463	642057	+	SYM1	YLR251W		641463,	642057,	Protein required for ethanol metabolism  induced by heat shock and localized to the inner mitochondrial membrane  homologous to mammalian peroxisomal membrane protein Mpv17
chrXII	641956	642262	641956	642262	+	YLR252W	YLR252W		641956,	642262,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
chrXII	642626	644336	642626	644336	+	YLR253W	YLR253W		642626,	644336,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  transcription is periodic during the metabolic cycle  YLR253W is not an essential gene
chrXII	644403	644973	644403	644973	-	NDL1	YLR254C		644403,	644973,	Homolog of nuclear distribution factor NudE, NUDEL  interacts with Pac1p and regulates dynein targeting to microtubule plus ends
chrXII	645599	645953	645599	645953	-	YLR255C	YLR255C		645599,	645953,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	646414	650923	646414	650923	+	HAP1	YLR256W		646414,	650923,	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen  the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
chrXII	651116	652439	651116	652439	+	YLR256W-A	YLR256W-A		651116,	652439,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXII	658825	659791	658825	659791	+	YLR257W	YLR257W		658825,	659791,	Putative protein of unknown function
chrXII	660715	662833	660715	662833	+	GSY2	YLR258W		660715,	662833,	Glycogen synthase, similar to Gsy1p  expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase  activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
chrXII	663283	665002	663283	665002	-	HSP60	YLR259C		663283,	665002,	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly  prevents aggregation and mediates protein refolding after heat shock  role in mtDNA transmission  phosphorylated
chrXII	665843	667907	665843	667907	+	LCB5	YLR260W		665843,	667907,	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
chrXII	668236	668563	668236	668563	-	VPS63	YLR261C		668236,	668563,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  98% of ORF overlaps the verified gene YPT6  deletion causes a vacuolar protein sorting defect
chrXII	668243	668891	668243	668891	-	YPT6	YLR262C		668243,	668891,	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y  has similarity to the human GTPase, Rab6
chrXII	669467	669662	669467	669662	-	TMA7	YLR262C-A		669467,	669662,	Protein of unknown that associates with ribosomes  null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
chrXII	670339	672823	670339	672823	+	RED1	YLR263W		670339,	672823,	Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division  critical for coupling checkpoint signaling to SC formation  interacts with Hop1p, Mec3p and Ddc1p
chrXII	673130	673334	673130	673334	+	RPS28B	YLR264W		673130,	673334,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein
chrXII	673827	673944	673827	673944	-	YLR264C-A	YLR264C-A		673827,	673944,	Putative protein of unknown function
chrXII	674426	675455	674426	675455	-	NEJ1	YLR265C		674426,	675455,	Protein involved in regulation of nonhomologous end joining  interacts with DNA ligase IV components Dnl4p and Lif1p  repressed by MAT heterozygosity  regulates cellular distribution of Lif1p
chrXII	675618	677724	675618	677724	-	PDR8	YLR266C		675618,	677724,	Transcription factor  targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
chrXII	678211	679924	678211	679924	+	BOP2	YLR267W		678211,	679924,	Protein of unknown function
chrXII	680199	680844	680199	680844	+	SEC22	YLR268W		680199,	680844,	R-SNARE protein  assembles into SNARE complex with Bet1p, Bos1p and Sed5p  cycles between the ER and Golgi complex  involved in anterograde and retrograde transport between the ER and Golgi  synaptobrevin homolog
chrXII	680865	681216	680865	681216	-	YLR269C	YLR269C		680865,	681216,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	681185	682238	681185	682238	+	DCS1	YLR270W		681185,	682238,	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif  interacts with neutral trehalase Nth1p
chrXII	682736	683561	682736	683561	+	YLR271W	YLR271W		682736,	683561,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
chrXII	683671	687202	683671	687202	-	YCS4	YLR272C		683671,	687202,	Subunit of the condensin complex  required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus
chrXII	689082	691029	689082	691029	-	PIG1	YLR273C		689082,	691029,	Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
chrXII	691554	693882	691554	693882	+	MCM5	YLR274W		691554,	693882,	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
chrXII	694377	694800	694377	694800	+	SMD2	YLR275W		694377,694472,	694382,694800,	Core Sm protein Sm D2  part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs  homolog of human Sm D2
chrXII	695045	696830	695045	696830	-	DBP9	YLR276C		695045,	696830,	ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
chrXII	697155	699495	697155	699495	-	YSH1	YLR277C		697155,	699495,	Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex  required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs
chrXII	699998	704024	699998	704024	-	YLR278C	YLR278C		699998,	704024,	Zinc-cluster protein  GFP-fusion protein localizes to the nucleus  mutant shows moderate growth defect on caffeine  has a prion-domain like fragment that increases frequency of [URE3]  YLR278C is not an essential gene
chrXII	704308	704698	704308	704698	+	YLR279W	YLR279W		704308,	704698,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	704482	704833	704482	704833	-	YLR280C	YLR280C		704482,	704833,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	704492	704960	704492	704960	-	YLR281C	YLR281C		704492,	704960,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria  YLR281C is not an essential gene
chrXII	705070	705412	705070	705412	-	YLR282C	YLR282C		705070,	705412,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  deletion mutation confers an increase in Ty1 transposition
chrXII	705185	706130	705185	706130	+	YLR283W	YLR283W		705185,	706130,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria  YLR283W is not an essential gene
chrXII	706197	707040	706197	707040	-	ECI1	YLR284C		706197,	707040,	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
chrXII	707359	708145	707359	708145	+	NNT1	YLR285W		707359,	708145,	Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
chrXII	708167	708338	708167	708338	-	YLR285C-A	YLR285C-A		708167,	708338,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXII	708447	710136	708447	710136	-	CTS1	YLR286C		708447,	710136,	Endochitinase, required for cell separation after mitosis  transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
chrXII	708561	708696	708561	708696	+	YLR286W-A	YLR286W-A		708561,	708696,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene CTS1
chrXII	710990	712058	710990	712058	-	YLR287C	YLR287C		710990,	712058,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YLR287C is not an essential gene
chrXII	712536	713158	712536	713158	-	RPS30A	YLR287C-A		712536,713155,	712725,713158,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
chrXII	713479	714904	713479	714904	-	MEC3	YLR288C		713479,	714904,	DNA damage and meiotic pachytene checkpoint protein  subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex  homolog of human and S. pombe Hus1
chrXII	715088	717026	715088	717026	+	GUF1	YLR289W		715088,	717026,	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes  important for translation under temperature and nutrient stress  may have a role in translational fidelity  similar to bacterial LepA elongation factor
chrXII	717144	717978	717144	717978	-	YLR290C	YLR290C		717144,	717978,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  YLR290C is not an essential gene
chrXII	718316	719462	718316	719462	-	GCD7	YLR291C		718316,	719462,	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2  activity subsequently regulated by phosphorylated eIF2  first identified as a negative regulator of GCN4 expression
chrXII	719788	720370	719788	720370	-	SEC72	YLR292C		719788,	720370,	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)  with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
chrXII	720770	721430	720770	721430	-	GSP1	YLR293C		720770,	721430,	Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport  regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p  yeast Gsp2p homolog
chrXII	721700	722030	721700	722030	-	YLR294C	YLR294C		721700,	722030,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene ATP14
chrXII	721998	722373	721998	722373	-	ATP14	YLR295C		721998,	722373,	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
chrXII	722977	723304	722977	723304	+	YLR296W	YLR296W		722977,	723304,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	724043	724433	724043	724433	+	YLR297W	YLR297W		724043,	724433,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole  YLR297W is not an essential gene  induced by treatment with 8-methoxypsoralen and UVA irradiation
chrXII	724720	725416	724720	725416	-	YHC1	YLR298C		724720,	725416,	Component of the U1 snRNP complex required for pre-mRNA splicing  putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
chrXII	726068	728051	726068	728051	+	ECM38	YLR299W		726068,	728051,	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme  involved in detoxification of electrophilic xenobiotics  expression induced mainly by nitrogen starvation
chrXII	727910	728003	727910	728003	-	YLR299C-A	YLR299C-A		727910,	728003,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene ECM38
chrXII	728954	730301	728954	730301	+	EXG1	YLR300W		728954,	730301,	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly  exists as three differentially glycosylated isoenzymes
chrXII	730824	731559	730824	731559	+	YLR301W	YLR301W		730824,	731559,	Protein of unknown function that interacts with Sec72p and Hrr25p
chrXII	732190	732553	732190	732553	-	YLR302C	YLR302C		732190,	732553,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	732541	733876	732541	733876	+	MET17	YLR303W		732541,	733876,	Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
chrXII	735211	737548	735211	737548	-	ACO1	YLR304C		735211,	737548,	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance  phosphorylated  component of the mitochondrial nucleoid  mutation leads to glutamate auxotrophy
chrXII	738160	743863	738160	743863	-	STT4	YLR305C		738160,	743863,	Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway  required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
chrXII	744150	744851	744150	744851	+	UBC12	YLR306W		744150,744287,	744153,744851,	Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins  related to E2 ubiquitin-conjugating enzymes
chrXII	745619	746525	745619	746525	+	CDA1	YLR307W		745619,	746525,	Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan  required for proper rigidity of the ascospore wall
chrXII	746847	747111	746847	747111	-	YLR307C-A	YLR307C-A		746847,	747111,	Putative protein of unknown function
chrXII	747936	748875	747936	748875	+	CDA2	YLR308W		747936,	748875,	Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan  required for proper rigidity of the ascospore wall
chrXII	749033	751769	749033	751769	-	IMH1	YLR309C		749033,	751769,	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
chrXII	752223	756993	752223	756993	-	CDC25	YLR310C		752223,	756993,	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor)  indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP  required for progression through G1
chrXII	757264	757612	757264	757612	-	YLR311C	YLR311C		757264,	757612,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	757636	758833	757636	758833	-	YLR312C	YLR312C		757636,	758833,	Putative protein of unknown function
chrXII	759479	760241	759479	760241	+	MRPL15	YLR312W-A		759479,	760241,	Mitochondrial ribosomal protein of the large subunit
chrXII	760749	762342	760749	762342	-	SPH1	YLR313C		760749,	762342,	Protein involved in shmoo formation and bipolar bud site selection  homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
chrXII	762574	764137	762574	764137	-	CDC3	YLR314C		762574,	764137,	Component of the septin ring of the mother-bud neck that is required for cytokinesis  septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
chrXII	764807	765269	764807	765269	+	NKP2	YLR315W		764807,	765269,	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
chrXII	765265	766358	765265	766358	-	TAD3	YLR316C		765265,766129,766249,	766073,766181,766358,	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
chrXII	765654	766089	765654	766089	+	YLR317W	YLR317W		765654,	766089,	Dubious open reading frame  may be part of a bicistronic transcript with NKP2/YLR315W  overlaps the verified ORF TAD3/YLR316C
chrXII	766541	769196	766541	769196	+	EST2	YLR318W		766541,	769196,	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function  mutations in human homolog are associated with aplastic anemia
chrXII	769317	771684	769317	771684	-	BUD6	YLR319C		769317,	771684,	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth  isolated as bipolar budding mutant  potential Cdc28p substrate
chrXII	771939	776304	771939	776304	+	MMS22	YLR320W		771939,	776304,	Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks  required for accurate meiotic chromosome segregation
chrXII	776583	777864	776583	777864	-	SFH1	YLR321C		776583,	777864,	Component of the RSC chromatin remodeling complex  essential gene required for cell cycle progression and maintenance of proper ploidy  phosphorylated in the G1 phase of the cell cycle  Snf5p paralog
chrXII	777627	777942	777627	777942	+	VPS65	YLR322W		777627,	777942,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  75% of ORF overlaps the verified gene SFH1  deletion causes a vacuolar protein sorting defect and blocks anaerobic growth
chrXII	778172	778952	778172	778952	-	CWC24	YLR323C		778172,	778952,	Essential protein, component of a complex containing Cef1p  has similarity to S. pombe Cwf24p
chrXII	779214	780786	779214	780786	+	PEX30	YLR324W		779214,	780786,	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number  partially functionally redundant with Pex31p  genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
chrXII	781142	781379	781142	781379	-	RPL38	YLR325C		781142,	781379,	Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
chrXII	782173	782896	782173	782896	+	YLR326W	YLR326W		782173,	782896,	Putative protein of unknown function, predicted to be palmitoylated
chrXII	783126	783387	783126	783387	-	TMA10	YLR327C		783126,	783387,	Protein of unknown function that associates with ribosomes  putative homolog of the F1F0-ATPase synthase regulator Stf2p
chrXII	784912	786118	784912	786118	+	NMA1	YLR328W		784912,	786118,	Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
chrXII	786441	787333	786441	787333	+	REC102	YLR329W		786441,786712,	786615,787333,	Protein involved in early stages of meiotic recombination  required for chromosome synapsis  forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
chrXII	787663	789679	787663	789679	+	CHS5	YLR330W		787663,	789679,	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
chrXII	790668	791046	790668	791046	-	JIP3	YLR331C		790668,	791046,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  98% of ORF overlaps the verified gene MID2
chrXII	790675	791806	790675	791806	+	MID2	YLR332W		790675,	791806,	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway  interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
chrXII	795572	795899	795572	795899	-	RPS25B	YLR333C		795572,	795899,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
chrXII	796697	797078	796697	797078	-	YLR334C	YLR334C		796697,	797078,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
chrXII	797429	799592	797429	799592	+	NUP2	YLR335W		797429,	799592,	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels  also has a role in chromatin organization
chrXII	799696	802396	799696	802396	-	SGD1	YLR336C		799696,	802396,	Essential nuclear protein, required for biogenesis of the small ribosomal subunit  has a possible role in the osmoregulatory glycerol response  putative homolog of human NOM1 which is implicated in acute myeloid leukemia
chrXII	802652	805106	802652	805106	-	VRP1	YLR337C		802652,	805106,	Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis  related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
chrXII	804345	805203	804345	805203	+	OPI9	YLR338W		804345,	805203,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF VRP1/YLR337C
chrXII	805783	806335	805783	806335	-	YLR339C	YLR339C		805783,	806335,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the essential gene RPP0
chrXII	805886	806825	805886	806825	+	RPP0	YLR340W		805886,	806825,	Conserved ribosomal protein P0 of the ribosomal stalk, which is involved in interaction between translational elongation factors and the ribosome  similar to rat P0, human P0, and E. coli L10e  phosphorylated on serine 302
chrXII	807384	808818	807384	808818	+	SPO77	YLR341W		807384,	808818,	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation  dispensable for both nuclear divisions during meiosis
chrXII	809996	815627	809996	815627	+	FKS1	YLR342W		809996,	815627,	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p  binds to regulatory subunit Rho1p  involved in cell wall synthesis and maintenance  localizes to sites of cell wall remodeling
chrXII	815809	815983	815809	815983	+	YLR342W-A	YLR342W-A		815809,	815983,	Putative protein of unknown function
chrXII	816093	817761	816093	817761	+	GAS2	YLR343W		816093,	817761,	1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly  has similarity to Gas1p
chrXII	819311	820142	819311	820142	+	RPL26A	YLR344W		819311,819777,	819330,820142,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins  binds to 5.8S rRNA
chrXII	820510	822040	820510	822040	+	YLR345W	YLR345W		820510,	822040,	Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate  mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex  YLR345W is not an essential gene
chrXII	822286	822592	822286	822592	-	YLR346C	YLR346C		822286,	822592,	Putative protein of unknown function found in mitochondria  expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p  YLR346C is not an essential gene
chrXII	823827	826413	823827	826413	-	KAP95	YLR347C		823827,	826413,	Karyopherin beta, forms a complex with Srp1p/Kap60p  interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex  regulates PC biosynthesis  GDP-to-GTP exchange factor for Gsp1p
chrXII	824788	824929	824788	824929	+	YLR347W-A	YLR347W-A		824788,	824929,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified ORF KAP95/YLR347C
chrXII	826976	827873	826976	827873	-	DIC1	YLR348C		826976,	827873,	Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
chrXII	827520	828027	827520	828027	+	YLR349W	YLR349W		827520,	828027,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified ORF DIC1/YLR348C
chrXII	828729	829380	828729	829380	+	ORM2	YLR350W		828729,	829380,	Evolutionarily conserved protein, similar to Orm1p, required for resistance to agents that induce unfolded protein response  Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
chrXII	829488	830364	829488	830364	-	NIT3	YLR351C		829488,	830364,	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor  nitrilase superfamily member
chrXII	831115	833539	831115	833539	+	YLR352W	YLR352W		831115,	833539,	Putative protein of unknown function with similarity to F-box proteins  interacts with Skp1p and Cdc53p  YLR352W is not an essential gene
chrXII	834351	836163	834351	836163	+	BUD8	YLR353W		834351,	836163,	Protein involved in bud-site selection  diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
chrXII	836349	837357	836349	837357	-	TAL1	YLR354C		836349,	837357,	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway  converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
chrXII	838065	839253	838065	839253	-	ILV5	YLR355C		838065,	839253,	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein  involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA  found in mitochondrial nucleoids
chrXII	840320	840914	840320	840914	+	ATG33	YLR356W		840320,	840914,	Mitochondrial mitophagy-specific protein  required primarily for mitophagy induced at the post-log phase  not required for other types of selective autophagy or macroautophagy  conserved within fungi, but not in higher eukaryotes
chrXII	841330	844000	841330	844000	+	RSC2	YLR357W		841330,	844000,	Component of the RSC chromatin remodeling complex  required for expression of mid-late sporulation-specific genes  involved in telomere maintenance
chrXII	843486	844050	843486	844050	-	YLR358C	YLR358C		843486,	844050,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF RSC2/YLR357W
chrXII	844281	845730	844281	845730	+	ADE13	YLR359W		844281,	845730,	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway  expression is repressed by adenine and activated by Bas1p and Pho2p  mutations in human ortholog ADSL cause adenylosuccinase deficiency
chrXII	846102	847422	846102	847422	+	VPS38	YLR360W		846102,	847422,	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting  binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity
chrXII	847387	849124	847387	849124	-	DCR2	YLR361C		847387,	849124,	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p  dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
chrXII	849382	849679	849382	849679	-	YLR361C-A	YLR361C-A		849382,	849679,	Putative protein of unknown function
chrXII	849865	852019	849865	852019	+	STE11	YLR362W		849865,	852019,	Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p  regulated by Ste20p and Ste50p
chrXII	852494	853151	852494	853151	-	NMD4	YLR363C		852494,	853151,	Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway
chrXII	853460	853718	853460	853718	+	YLR363W-A	YLR363W-A		853460,	853718,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus
chrXII	854061	854391	854061	854391	+	GRX8	YLR364W		854061,	854391,	Glutaredoxin that employs a dithiol mechanism of catalysis  monomeric  activity is low and null mutation does not affect sensitivity to oxidative stress  GFP-fusion protein localizes to the cytoplasm  expression strongly induced by arsenic
chrXII	855198	855531	855198	855531	+	YLR365W	YLR365W		855198,	855531,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps dubious gene YLR364C-A  YLR365W is not an essential gene
chrXII	855522	855645	855522	855645	-	YLR364C-A	YLR364C-A		855522,	855645,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YLR366W
chrXII	855537	855843	855537	855843	+	YLR366W	YLR366W		855537,	855843,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YLR364C-A
chrXII	856441	857317	856441	857317	+	RPS22B	YLR367W		856441,857057,	856574,857317,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
chrXII	857539	859336	857539	859336	+	MDM30	YLR368W		857539,	859336,	F-box component of an SCF ubiquitin protein ligase complex  associates with and is required for Fzo1p ubiquitination and for mitochondria fusion  stimulates nuclear export of specific mRNAs  promotes ubiquitin-mediated degradation of Gal4p in some strains
chrXII	859551	861525	859551	861525	+	SSQ1	YLR369W		859551,	861525,	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
chrXII	861717	862254	861717	862254	-	ARC18	YLR370C		861717,	862254,	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
chrXII	862713	866784	862713	866784	+	ROM2	YLR371W		862713,	866784,	GDP/GTP exchange factor (GEF) for Rho1p and Rho2p  mutations are synthetically lethal with mutations in rom1, which also encodes a GEF
chrXII	867353	868391	867353	868391	+	SUR4	YLR372W		867353,	868391,	Elongase, involved in fatty acid and sphingolipid biosynthesis  synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers  involved in regulation of sphingolipid biosynthesis
chrXII	868661	871367	868661	871367	-	VID22	YLR373C		868661,	871367,	Glycosylated integral membrane protein localized to the plasma membrane  plays a role in fructose-1,6-bisphosphatase (FBPase) degradation  involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
chrXII	871452	871842	871452	871842	-	YLR374C	YLR374C		871452,	871842,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF STP3/YLR375W
chrXII	871696	872728	871696	872728	+	STP3	YLR375W		871696,	872728,	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
chrXII	872825	873554	872825	873554	-	PSY3	YLR376C		872825,	873554,	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair  deletion results in a mutator phenotype  deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
chrXII	873745	874792	873745	874792	-	FBP1	YLR377C		873745,	874792,	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism  undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions  interacts with Vid30p
chrXII	875735	877178	875735	877178	-	SEC61	YLR378C		875735,	877178,	Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p)  forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER  with Sec63 complex allows SRP-independent protein import into ER
chrXII	876921	877296	876921	877296	+	YLR379W	YLR379W		876921,	877296,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the essential ORF SEC61/YLR378C
chrXII	878281	879508	878281	879508	+	CSR1	YLR380W		878281,	879508,	Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions  interacts specifically with thioredoxin peroxidase  may have a role in oxidative stress resistance
chrXII	879722	881924	879722	881924	+	CTF3	YLR381W		879722,	881924,	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p  may bind the kinetochore to spindle microtubules
chrXII	882066	884751	882066	884751	-	NAM2	YLR382C		882066,	884751,	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns  indirectly required for mitochondrial genome maintenance
chrXII	885287	888632	885287	888632	+	SMC6	YLR383W		885287,	888632,	Protein involved in structural maintenance of chromosomes  essential subunit of Mms21-Smc5-Smc6 complex  required for growth, DNA repair, interchromosomal and sister chromatid recombination  homologous to S. pombe rad18
chrXII	888850	892900	888850	892900	-	IKI3	YLR384C		888850,	892900,	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA  maintains structural integrity of Elongator  homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
chrXII	892991	893390	892991	893390	-	SWC7	YLR385C		892991,	893390,	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
chrXII	893627	896270	893627	896270	+	VAC14	YLR386W		893627,	896270,	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity  interacts with Fig4p  activator of Fab1p
chrXII	896373	897672	896373	897672	-	REH1	YLR387C		896373,	897672,	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles  similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation  contains dispersed C2H2 zinc finger domains
chrXII	898650	898821	898650	898821	+	RPS29A	YLR388W		898650,	898821,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
chrXII	899576	902660	899576	902660	-	STE23	YLR389C		899576,	902660,	Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form  expressed in both haploids and diploids  member of the insulin-degrading enzyme family
chrXII	903065	903404	903065	903404	+	ECM19	YLR390W		903065,	903404,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXII	903723	904440	903723	904440	+	CCW14	YLR390W-A		903723,	904440,	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
chrXII	904748	906305	904748	906305	-	ART10	YLR392C		904748,	906305,	Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p  overexpression confers resistance to arsenite  green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm  non-essential gene
chrXII	907078	907918	907078	907918	+	ATP10	YLR393W		907078,	907918,	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
chrXII	907949	909398	907949	909398	+	CST9	YLR394W		907949,	909398,	SUMO E3 ligase  required for synaptonemal complex formation  localizes to synapsis initiation sites on meiotic chromosomes  potential Cdc28p substrate
chrXII	909728	909965	909728	909965	-	COX8	YLR395C		909728,	909965,	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
chrXII	910234	912310	910234	912310	-	VPS33	YLR396C		910234,	912310,	ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex  essential for protein sorting, vesicle docking and fusion at the vacuole
chrXII	912549	914892	912549	914892	-	AFG2	YLR397C		912549,	914892,	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex  is essential for pre-60S maturation and release of several preribosome maturation factors  may be involved in degradation of aberrant mRNAs
chrXII	915155	919019	915155	919019	-	SKI2	YLR398C		915155,	919019,	Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome  null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
chrXII	919535	921596	919535	921596	-	BDF1	YLR399C		919535,	921596,	Protein involved in transcription initiation at TATA-containing promoters  associates with the basal transcription factor TFIID  contains two bromodomains  corresponds to the C-terminal region of mammalian TAF1  redundant with Bdf2p
chrXII	920868	920973	920868	920973	+	YLR399W-A	YLR399W-A		920868,	920973,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the characterized ORF BDF1/YLR399C
chrXII	922062	922536	922062	922536	+	YLR400W	YLR400W		922062,	922536,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	922441	924448	922441	924448	-	DUS3	YLR401C		922441,	924448,	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p  contains a consensus oleate response element (ORE) in its promoter region
chrXII	924888	925080	924888	925080	+	YLR402W	YLR402W		924888,	925080,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	925567	927619	925567	927619	+	SFP1	YLR403W		925567,	927619,	Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size  regulated by TORC1 and Mrs6p  can form the [ISP+] prion
chrXII	928742	929600	928742	929600	+	FLD1	YLR404W		928742,	929600,	Seipin protein involved in lipid droplet morphology, number, and size  proposed to be involved in lipid metabolism  related to the human BSCL2 which is associated with lipodystrophy
chrXII	929788	930892	929788	930892	+	DUS4	YLR405W		929788,	930892,	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
chrXII	931064	931755	931064	931755	-	RPL31B	YLR406C		931064,931698,	931349,931755,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein  associates with the karyopherin Sxm1p  loss of both Rpl31p and Rpl39p confers lethality
chrXII	932205	932355	932205	932355	-	YLR406C-A	YLR406C-A		932205,	932355,	Putative protein of unknown function
chrXII	932966	933653	932966	933653	+	YLR407W	YLR407W		932966,	933653,	Putative protein of unknown function  null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
chrXII	933884	934253	933884	934253	-	BLS1	YLR408C		933884,	934253,	Putative protein of unknown function  likely member of BLOC complex involved in endosomal cargo sorting  green fluorescent protein (GFP)-fusion protein localizes to the endosome  YLR408C is not an essential gene
chrXII	934413	937233	934413	937233	-	UTP21	YLR409C		934413,	937233,	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit  synthetic defect with STI1 Hsp90 cochaperone  human homolog linked to glaucoma
chrXII	937540	940981	937540	940981	+	VIP1	YLR410W		937540,	940981,	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase  IP7 production is important for phosphate signaling  involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1
chrXII	941482	946796	941482	946796	+	YLR410W-B	YLR410W-B		941482,942776,	942775,946796,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXII	941482	942799	941482	942799	+	YLR410W-A	YLR410W-A		941482,	942799,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXII	947252	947978	947252	947978	+	CTR3	YLR411W		947252,	947978,	High-affinity copper transporter of the plasma membrane, acts as a trimer  gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
chrXII	948367	949192	948367	949192	+	BER1	YLR412W		948367,	949192,	Protein involved in microtubule-related processes, N-acetylation  GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS  YLR412W is not an essential gene  similar to Arabidopsis SRR1 gene
chrXII	950266	950473	950266	950473	-	YLR412C-A	YLR412C-A		950266,	950473,	Putative protein of unknown function
chrXII	951155	953183	951155	953183	+	YLR413W	YLR413W		951155,	953183,	Putative protein of unknown function  YLR413W is not an essential gene
chrXII	953352	954144	953352	954144	-	PUN1	YLR414C		953352,	954144,	Plasma membrane protein with a role in cell wall integrity  co-localizes with Sur7p in punctate membrane patches  null mutant displays decreased thermotolerance  transcription induced upon cell wall damage and metal ion stress
chrXII	954258	954597	954258	954597	-	YLR415C	YLR415C		954258,	954597,	Putative protein of unknown function  YLR415C is not an essential gene
chrXII	954490	954889	954490	954889	-	YLR416C	YLR416C		954490,	954889,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	955009	956710	955009	956710	+	VPS36	YLR417W		955009,	956710,	Component of the ESCRT-II complex  contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
chrXII	956913	958095	956913	958095	-	CDC73	YLR418C		956913,	958095,	Component of the Paf1p complex  binds to and modulates the activity of RNA polymerases I and II  required for expression of certain genes, modification of some histones, and telomere maintenance  involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
chrXII	958427	962735	958427	962735	+	YLR419W	YLR419W		958427,	962735,	Putative helicase with limited sequence similarity to human Rb protein  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  YLR419W is not an essential gene
chrXII	963784	964879	963784	964879	+	URA4	YLR420W		963784,	964879,	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
chrXII	965089	965560	965089	965560	-	RPN13	YLR421C		965089,	965560,	Subunit of the 19S regulatory particle of the 26S proteasome lid  acts as a ubiquitin receptor for the proteasome  null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability
chrXII	965896	971695	965896	971695	+	YLR422W	YLR422W		965896,	971695,	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors)  interacts with Ino4p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
chrXII	971916	973170	971916	973170	-	ATG17	YLR423C		971916,	973170,	Scaffold protein responsible for phagophore assembly site organization  regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p  stimulates Atg1p kinase activity  human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells
chrXII	973394	975521	973394	975521	+	SPP382	YLR424W		973394,	975521,	Essential protein that forms a dimer with Ntr2p  also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly  found also in a multisubunit complex with the splicing factor Clf1p  suppressor of prp38-1 mutation
chrXII	982893	986817	982893	986817	+	TUS1	YLR425W		982893,	986817,	Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway  multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation  potential Cdc28p substrate
chrXII	987061	988113	987061	988113	+	YLR426W	YLR426W		987061,987212,	987141,988113,	Putative protein of unknown function  detected in highly purified mitochondria in high-throughput studies  proposed to be involved in resistance to mechlorethamine and streptozotocin  null mutant sensitive to expression of top1-T722A allele
chrXII	988427	990440	988427	990440	+	MAG2	YLR427W		988427,	990440,	Cytoplasmic protein of unknown function  induced in response to mycotoxin patulin  ubiquitinated protein similar to the human ring finger motif protein RNF10  predicted to be involved in repair of alkylated DNA due to interaction with MAG1
chrXII	990616	990961	990616	990961	-	YLR428C	YLR428C		990616,	990961,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF CRN1
chrXII	990776	992732	990776	992732	+	CRN1	YLR429W		990776,	992732,	Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity  plays a role in regulation of actin patch assembly
chrXII	993433	1000129	993433	1000129	+	SEN1	YLR430W		993433,	1000129,	Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs  homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis
chrXII	1000341	1001703	1000341	1001703	-	ATG23	YLR431C		1000341,	1001703,	Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy  cycles between the phagophore assembly site (PAS) and non-PAS locations  forms a complex with Atg9p and Atg27p
chrXII	1002556	1004128	1002556	1004128	+	IMD3	YLR432W		1002556,	1004128,	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
chrXII	1004346	1006008	1004346	1006008	-	CNA1	YLR433C		1004346,	1006008,	Calcineurin A  one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
chrXII	1006024	1006408	1006024	1006408	-	YLR434C	YLR434C		1006024,	1006408,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF TSR2/YLR435W
chrXII	1006377	1006995	1006377	1006995	+	TSR2	YLR435W		1006377,	1006995,	Protein with a potential role in pre-rRNA processing
chrXII	1007420	1011245	1007420	1011245	-	ECM30	YLR436C		1007420,	1011245,	Putative protein of unknown function  may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects  (GFP)-fusion protein localizes to the cytoplasm
chrXII	1011621	1012023	1011621	1012023	-	DIF1	YLR437C		1011621,	1012023,	Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits  phosphorylated by Dun1p in response to DNA damage and degraded  N-terminal half has similarity to S. pombe Spd1 protein
chrXII	1012458	1012686	1012458	1012686	-	YLR437C-A	YLR437C-A		1012458,	1012686,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF CAR2/YLR438W
chrXII	1012500	1013775	1012500	1013775	+	CAR2	YLR438W		1012500,	1013775,	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process  not nitrogen catabolite repression sensitive
chrXII	1013908	1014178	1013908	1014178	-	LSM3	YLR438C-A		1013908,	1014178,	Lsm (Like Sm) protein  part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay  nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
chrXII	1014490	1015450	1014490	1015450	+	MRPL4	YLR439W		1014490,	1015450,	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein  located at the ribosomal tunnel exit
chrXII	1015567	1017697	1015567	1017697	-	SEC39	YLR440C		1015567,	1017697,	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p  proposed to be involved in protein secretion  localizes to the ER and nuclear envelope
chrXII	1018140	1018908	1018140	1018908	-	RPS1A	YLR441C		1018140,	1018908,	Ribosomal protein 10 (rp10) of the small (40S) subunit  nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
chrXII	1019314	1022251	1019314	1022251	-	SIR3	YLR442C		1019314,	1022251,	Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state  required for spreading of silenced chromatin  recruited to chromatin through interaction with Rap1p
chrXII	1022624	1023971	1022624	1023971	+	ECM7	YLR443W		1022624,	1023971,	Non-essential putative integral membrane protein with a role in calcium uptake  mutant has cell wall defects and Ca+ uptake deficiencies  transcription is induced under conditions of zinc deficiency
chrXII	1023685	1023988	1023685	1023988	-	YLR444C	YLR444C		1023685,	1023988,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXII	1024188	1024837	1024188	1024837	+	YLR445W	YLR445W		1024188,1024654,	1024572,1024837,	Putative protein of unknown function  transcription is regulated by Ume6p and induced in response to alpha factor
chrXII	1025213	1026515	1025213	1026515	+	YLR446W	YLR446W		1025213,	1026515,	Putative protein of unknown function with similarity to hexokinases  transcript is upregulated during sporulation and the unfolded protein response  YLR446W is not an essential gene
chrXII	1026855	1027893	1026855	1027893	-	VMA6	YLR447C		1026855,	1027893,	Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system  stabilizes VO subunits  required for V1 domain assembly on the vacuolar membrane
chrXII	1028853	1029768	1028853	1029768	+	RPL6B	YLR448W		1028853,1029252,	1028868,1029768,	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein  binds to 5.8S rRNA
chrXII	1030833	1032012	1030833	1032012	+	FPR4	YLR449W		1030833,	1032012,	Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus  catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
chrXII	1032626	1035764	1032626	1035764	+	HMG2	YLR450W		1032626,	1035764,	One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis  overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks
chrXII	1036092	1038753	1036092	1038753	+	LEU3	YLR451W		1036092,	1038753,	Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation  positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis
chrXII	1039269	1041366	1039269	1041366	-	SST2	YLR452C		1039269,	1041366,	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone  also required to prevent receptor-independent signaling of the mating pathway  member of the RGS (regulator of G-protein signaling) family
chrXII	1041798	1042986	1041798	1042986	-	RIF2	YLR453C		1041798,	1042986,	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing  deletion results in telomere elongation
chrXII	1043997	1051884	1043997	1051884	+	FMP27	YLR454W		1043997,	1051884,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXII	1053628	1054543	1053628	1054543	+	YLR455W	YLR455W		1053628,	1054543,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus  deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
chrXII	1055069	1055684	1055069	1055684	+	YLR456W	YLR456W		1055069,	1055684,	Putative protein of unknown function  null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
chrXII	1055811	1056771	1055811	1056771	-	NBP1	YLR457C		1055811,	1056771,	Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication  essential for bipolar spindle formation  component of the Mps2p-Bbp1p complex
chrXII	1056454	1056835	1056454	1056835	+	YLR458W	YLR458W		1056454,	1056835,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  overlaps 5' end of essential NBP1 gene required for mitosis
chrXII	1057333	1058518	1057333	1058518	+	GAB1	YLR459W		1057333,	1058518,	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins  may have a role in recognition of the attachment signal or of the lipid portion of GPI
chrXII	1059756	1060887	1059756	1060887	-	YLR460C	YLR460C		1059756,	1060887,	Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb  possibly up-regulated by iodine
chrXII	1062918	1063281	1062918	1063281	+	PAU4	YLR461W		1062918,	1063281,	Member of the seripauperin multigene family encoded mainly in subtelomeric regions  active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
chrXII	1065955	1066564	1065955	1066564	+	YLR462W	YLR462W		1065955,	1066564,	Putative protein of unknown function with similarity to helicases  YLR462W is within the telomere on the right arm of chromosome XII
chrXII	1066264	1066816	1066264	1066816	-	YLR463C	YLR463C		1066264,	1066816,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the uncharacterized ORFs YLR462W and YLR464W
chrXII	1066571	1067501	1066571	1067501	+	YLR464W	YLR464W		1066571,1067363,	1067084,1067501,	Putative protein of unknown function  intron is predicted but not detected experimentally  YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C
chrXII	1067044	1067353	1067044	1067353	-	BSC3	YLR465C		1067044,	1067353,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4
chrXII	1067086	1071235	1067086	1071235	+	YRF1-4	YLR466W		1067086,	1071235,	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1  potentially phosphorylated by Cdc28p
chrXII	1070386	1070869	1070386	1070869	-	YLR466C-A	YLR466C-A		1070386,	1070869,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YRF1-4/YLR466W
chrXII	1071593	1071710	1071593	1071710	-	YLR466C-B	YLR466C-B		1071593,	1071710,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXII	1072507	1077898	1072507	1077898	+	YRF1-5	YLR467W		1072507,	1077898,	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1  potentially phosphorylated by Cdc28p
chrXII	1077049	1077532	1077049	1077532	-	YLR467C-A	YLR467C-A		1077049,	1077532,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF YRF1-4/YLR466W
chrXIII	460	4684	460	4684	-	YML133C	YML133C		460,3890,	3791,4684,	Putative protein of unknown function with similarity to helicases  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  YML133C contains an intron
chrXIII	826	1309	826	1309	+	YML133W-B	YML133W-B		826,	1309,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the uncharacterized ORF YML133C
chrXIII	1609	2185	1609	2185	+	YML133W-A	YML133W-A		1609,	2185,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the uncharacterized ORF YML133C
chrXIII	7243	8383	7243	8383	+	COS3	YML132W		7243,	8383,	Protein involved in salt resistance  interacts with sodium:hydrogen antiporter Nha1p  member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrXIII	10197	11295	10197	11295	+	YML131W	YML131W		10197,	11295,	Putative protein of unknown function with similarity to medium chain dehydrogenase/reductases  expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals  GFP-fusion protein localizes to the cytoplasm
chrXIII	11482	13174	11482	13174	-	ERO1	YML130C		11482,	13174,	Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
chrXIII	14540	14753	14540	14753	-	COX14	YML129C		14540,	14753,	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV)  associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
chrXIII	15134	16676	15134	16676	-	MSC1	YML128C		15134,	16676,	Protein of unknown function  mutant is defective in directing meiotic recombination events to homologous chromatids  the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
chrXIII	17063	18809	17063	18809	+	RSC9	YML127W		17063,	18809,	Component of the RSC chromatin remodeling complex  DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
chrXIII	19059	20535	19059	20535	-	ERG13	YML126C		19059,	20535,	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA  involved in the second step in mevalonate biosynthesis
chrXIII	20760	21699	20760	21699	-	PGA3	YML125C		20760,	21699,	Putative cytochrome b5 reductase, localized to the plasma membrane  may be involved in regulation of lifespan  required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking
chrXIII	22047	23683	22047	23683	-	TUB3	YML124C		22047,23658,	23360,23683,	Alpha-tubulin  associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules  expressed at lower level than Tub1p
chrXIII	24036	25800	24036	25800	-	PHO84	YML123C		24036,	25800,	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter  regulated by Pho4p and Spt7p  mutation confers resistance to arsenate  exit from the ER during maturation requires Pho86p
chrXIII	26037	26418	26037	26418	-	YML122C	YML122C		26037,	26418,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIII	26929	27862	26929	27862	+	GTR1	YML121W		26929,	27862,	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle  component of GSE complex, which is required for sorting of Gap1p  involved in phosphate transport and telomeric silencing  similar to human RagA and RagB
chrXIII	28265	29807	28265	29807	-	NDI1	YML120C		28265,	29807,	NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I  phosphorylated  homolog of human AMID
chrXIII	30610	31684	30610	31684	+	YML119W	YML119W		30610,	31684,	Putative protein of unknown function  YML119W is not an essential gene  potential Cdc28p substrate
chrXIII	32333	33851	32333	33851	+	NGL3	YML118W		32333,	33851,	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p  similar to Ngl1p and Ngl2p
chrXIII	34242	37647	34242	37647	+	NAB6	YML117W		34242,	37647,	Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies  deletion mutants display increased sensitivity to some cell wall disrupting agents  expression negatively regulated by cAMP
chrXIII	37471	37774	37471	37774	+	YML116W-A	YML116W-A		37471,	37774,	Putative protein of unknown function
chrXIII	38195	39824	38195	39824	+	ATR1	YML116W		38195,	39824,	Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide
chrXIII	40186	41794	40186	41794	-	VAN1	YML115C		40186,	41794,	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis  mutants are vanadate-resistant
chrXIII	42042	43575	42042	43575	-	TAF8	YML114C		42042,	43575,	TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
chrXIII	44044	44791	44044	44791	+	DAT1	YML113W		44044,	44791,	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts  Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding  not essential for viability
chrXIII	45062	45953	45062	45953	+	CTK3	YML112W		45062,	45953,	Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity
chrXIII	46941	49704	46941	49704	+	BUL2	YML111W		46941,	49704,	Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
chrXIII	50030	50954	50030	50954	-	COQ5	YML110C		50030,	50954,	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis  localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
chrXIII	51639	54468	51639	54468	+	ZDS2	YML109W		51639,	54468,	Protein with a role in regulating Swe1p-dependent polarized growth  interacts with Cdc55p  interacts with silencing proteins at the telomere  implicated in the mitotic exit network through regulation of Cdc14p localization  paralog of Zds1p
chrXIII	54792	55110	54792	55110	+	YML108W	YML108W		54792,	55110,	Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YML108W is not an essential gene
chrXIII	55264	56269	55264	56269	-	PML39	YML107C		55264,	56269,	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p  anchored to nuclear pore complex via Mlp1p and Mlp2p  found with the subset of nuclear pores farthest from the nucleolus  may interact with ribosomes
chrXIII	56772	57453	56772	57453	+	URA5	YML106W		56772,	57453,	Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate  minor OPRTase encoded by URA10
chrXIII	57865	58687	57865	58687	-	SEC65	YML105C		57865,	58687,	Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER  interacts with Srp54p  homolog of mammalian SRP19
chrXIII	58938	62322	58938	62322	-	MDM1	YML104C		58938,	62322,	Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds  contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
chrXIII	62581	67549	62581	67549	-	NUP188	YML103C		62581,	67549,	Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
chrXIII	68293	69700	68293	69700	+	CAC2	YML102W		68293,	69700,	Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
chrXIII	69408	69726	69408	69726	-	YML101C-A	YML101C-A		69408,	69726,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	69734	70088	69734	70088	-	CUE4	YML101C		69734,	70088,	Protein of unknown function  has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
chrXIII	70137	70311	70137	70311	+	YML100W-A	YML100W-A		70137,	70311,	Putative protein of unknown function  identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXIII	70623	73920	70623	73920	+	TSL1	YML100W		70623,	73920,	Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, similar to Tps3p and may share function  mutant has aneuploidy tolerance
chrXIII	74228	74558	74228	74558	+	YML099W-A	YML099W-A		74228,	74558,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF ARG81/YML099C
chrXIII	74397	77040	74397	77040	-	ARG81	YML099C		74397,	77040,	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes  acts with Arg80p and Arg82p
chrXIII	77266	77770	77266	77770	+	TAF13	YML098W		77266,	77770,	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
chrXIII	78334	79690	78334	79690	-	VPS9	YML097C		78334,	79690,	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport  specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors  binds ubiquitin
chrXIII	79908	81486	79908	81486	+	YML096W	YML096W		79908,	81486,	Putative protein of unknown function with similarity to asparagine synthetases  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YML096W is not an essential gene and partially overlaps the verified gene RAD10
chrXIII	81480	82113	81480	82113	-	RAD10	YML095C		81480,	82113,	Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair  subunit of Nucleotide Excision Repair Factor 1 (NEF1)  homolog of human ERCC1 protein
chrXIII	82218	82620	82218	82620	-	YML094C-A	YML094C-A		82218,	82620,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene GIM5/YML094W  deletion confers sensitivity to GSAO
chrXIII	82274	82849	82274	82849	+	GIM5	YML094W		82274,82373,	82290,82849,	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
chrXIII	83089	85789	83089	85789	+	UTP14	YML093W		83089,	85789,	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
chrXIII	85986	86739	85986	86739	-	PRE8	YML092C		85986,	86739,	Alpha 2 subunit of the 20S proteasome
chrXIII	87122	90731	87122	90731	-	RPM2	YML091C		87122,	90731,	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation  distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
chrXIII	90743	91130	90743	91130	+	YML090W	YML090W		90743,	91130,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YML089C  exhibits growth defect on a non-fermentable (respiratory) carbon source
chrXIII	91040	91409	91040	91409	-	YML089C	YML089C		91040,	91409,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  expression induced by calcium shortage
chrXIII	92234	94241	92234	94241	+	UFO1	YML088W		92234,	94241,	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex  binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
chrXIII	94430	95369	94430	95369	-	AIM33	YML087C		94430,	95369,	Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4  null mutant displays reduced frequency of mitochondrial genome loss
chrXIII	95790	97371	95790	97371	-	ALO1	YML086C		95790,	97371,	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
chrXIII	97940	99400	97940	99400	-	TUB1	YML085C		97940,99375,	99259,99400,	Alpha-tubulin  associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
chrXIII	99488	99797	99488	99797	+	YML084W	YML084W		99488,	99797,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIII	99793	101050	99793	101050	-	YML083C	YML083C		99793,	101050,	Putative protein of unknown function  transcriptionally regulated by Upc2p via an upstream sterol response element  strong increase in transcript abundance during anaerobic growth compared to aerobic growth  cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
chrXIII	101861	103811	101861	103811	+	YML082W	YML082W		101861,	103811,	Putative protein predicted to have carbon-sulfur lyase activity  transcriptionally regulated by Upc2p via an upstream sterol response element  green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm  YML082W is not an essential gene
chrXIII	103982	104162	103982	104162	-	ATP18	YML081C-A		103982,	104162,	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis  termed subunit I or subunit j  does not correspond to known ATP synthase subunits in other organisms
chrXIII	104776	108532	104776	108532	+	YML081W	YML081W		104776,	108532,	DNA-binding protein, putative transcription factor  green fluorescent protein (GFP)-fusion protein localizes to the nucleus  null mutant is sensitive to expression of the top1-T722A allele  not an essential gene
chrXIII	108805	110077	108805	110077	+	DUS1	YML080W		108805,	110077,	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p  modifies pre-tRNA(Phe) at U17
chrXIII	110246	110852	110246	110852	+	YML079W	YML079W		110246,	110852,	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin)  localizes to the nucleus and cytoplasm
chrXIII	111001	111550	111001	111550	+	CPR3	YML078W		111001,	111550,	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  involved in protein refolding after import into mitochondria
chrXIII	111864	112344	111864	112344	+	BET5	YML077W		111864,	112344,	Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
chrXIII	112512	115347	112512	115347	-	WAR1	YML076C		112512,	115347,	Homodimeric Zn2Cys6 zinc finger transcription factor  binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
chrXIII	115733	118898	115733	118898	-	HMG1	YML075C		115733,	118898,	One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis  localizes to the nuclear envelope  overproduction induces the formation of karmellae
chrXIII	120088	121324	120088	121324	-	FPR3	YML074C		120088,	121324,	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase)  FK506 binding protein  phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
chrXIII	123226	124172	123226	124172	-	RPL6A	YML073C		123226,124157,	123742,124172,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein  binds to 5.8S rRNA
chrXIII	124729	129367	124729	129367	-	TCB3	YML072C		124729,	129367,	Lipid-binding protein, localized to the bud via specific mRNA transport  non-tagged protein detected in a phosphorylated state in mitochondria  GFP-fusion protein localizes to the cell periphery  C-termini of Tcb1p, Tcb2p and Tcb3p interact
chrXIII	129748	131572	129748	131572	-	COG8	YML071C		129748,	131572,	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrXIII	133474	135229	133474	135229	+	DAK1	YML070W		133474,	135229,	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA)  involved in stress adaptation
chrXIII	135499	137158	135499	137158	+	POB3	YML069W		135499,	137158,	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases
chrXIII	137549	138944	137549	138944	+	ITT1	YML068W		137549,	138944,	Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
chrXIII	139062	140214	139062	140214	-	ERV41	YML067C		139062,140183,	140090,140214,	Protein localized to COPII-coated vesicles, forms a complex with Erv46p  involved in the membrane fusion stage of transport  has homology to human ERGIC2 (PTX1) protein
chrXIII	140423	141533	140423	141533	-	SMA2	YML066C		140423,	141533,	Meiosis-specific prospore membrane protein  required to produce bending force necessary for proper assembly of the prospore membrane during sporulation
chrXIII	142209	144954	142209	144954	+	ORC1	YML065W		142209,	144954,	Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing  exhibits ATPase activity
chrXIII	145138	145876	145138	145876	-	TEM1	YML064C		145138,	145876,	GTP-binding protein of the ras superfamily involved in termination of M-phase  controls actomyosin and septin dynamics during cytokinesis
chrXIII	146481	147249	146481	147249	+	RPS1B	YML063W		146481,	147249,	Ribosomal protein 10 (rp10) of the small (40S) subunit  nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
chrXIII	147504	148683	147504	148683	-	MFT1	YML062C		147504,	148683,	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination  involved in telomere maintenance
chrXIII	148952	151532	148952	151532	-	PIF1	YML061C		148952,	151532,	DNA helicase  exists in a nuclear form that acts as a catalytic inhibitor of telomerase  and as a mitochondrial form involved in repair and recombination of mitochondrial DNA  mutations affect zinc and iron homeostasis
chrXIII	151870	153001	151870	153001	+	OGG1	YML060W		151870,	153001,	Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
chrXIII	153218	158258	153218	158258	-	NTE1	YML059C		153218,	158258,	Serine esterase, homolog of human neuropathy target esterase (NTE)  Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
chrXIII	158759	158966	158759	158966	+	HUG1	YML058W-A		158759,	158966,	Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage
chrXIII	159382	159697	159382	159697	+	SML1	YML058W		159382,	159697,	Ribonucleotide reductase inhibitor involved in regulating dNTP production  regulated by Mec1p and Rad53p during DNA damage and S phase
chrXIII	160022	160412	160022	160412	-	YML057C-A	YML057C-A		160022,	160412,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene CMP2/YML057W
chrXIII	160179	161994	160179	161994	+	CMP2	YML057W		160179,	161994,	Calcineurin A  one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
chrXIII	162193	164176	162193	164176	-	IMD4	YML056C		162193,163716,	163308,164176,	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
chrXIII	164789	165326	164789	165326	+	SPC2	YML055W		164789,	165326,	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway  homologous to mammalian SPC25
chrXIII	165532	167308	165532	167308	-	CYB2	YML054C		165532,	167308,	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization  expression is repressed by glucose and anaerobic conditions
chrXIII	167622	167781	167622	167781	-	YML054C-A	YML054C-A		167622,	167781,	Putative protein of unknown function
chrXIII	169115	169754	169115	169754	-	YML053C	YML053C		169115,	169754,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus  overexpression causes a cell cycle delay or arrest  YML053C is not an essential gene
chrXIII	170401	171310	170401	171310	+	SUR7	YML052W		170401,	171310,	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches)  component of eisosomes  associated with endocytosis, along with Pil1p and Lsp1p  sporulation and plasma membrane sphingolipid content are altered in mutants
chrXIII	171593	172901	171593	172901	+	GAL80	YML051W		171593,	172901,	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose  inhibits transcriptional activation by Gal4p  inhibition relieved by Gal3p or Gal1p binding
chrXIII	173138	174074	173138	174074	+	AIM32	YML050W		173138,	174074,	Putative protein of unknown function  null mutant is viable and displays elevated frequency of mitochondrial genome loss
chrXIII	174219	178305	174219	178305	-	RSE1	YML049C		174219,	178305,	Protein involved in pre-mRNA splicing  component of the pre-spliceosome  associates with U2 snRNA  involved in ER to Golgi transport
chrXIII	178425	179637	178425	179637	+	GSF2	YML048W		178425,	179637,	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p  involved in glucose-dependent repression
chrXIII	179892	180258	179892	180258	+	YML047W-A	YML047W-A		179892,	180258,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	180016	181075	180016	181075	-	PRM6	YML047C		180016,	181075,	Pheromone-regulated protein, predicted to have 2 transmembrane segments  regulated by Ste12p during mating
chrXIII	181473	183363	181473	183363	+	PRP39	YML046W		181473,	183363,	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
chrXIII	184460	189729	184460	189729	+	YML045W	YML045W		184460,185766,	185765,189729,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXIII	184460	185783	184460	185783	+	YML045W-A	YML045W-A		184460,	185783,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXIII	190243	191767	190243	191767	-	RRN11	YML043C		190243,	191767,	Component of the core factor (CF) rDNA transcription factor complex  CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
chrXIII	192787	194800	192787	194800	+	CAT2	YML042W		192787,	194800,	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
chrXIII	194912	195755	194912	195755	-	VPS71	YML041C		194912,	195755,	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A  required for vacuolar protein sorting
chrXIII	196627	201896	196627	201896	+	YML039W	YML039W		196627,197933,	197932,201896,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXIII	196627	197950	196627	197950	+	YML040W	YML040W		196627,	197950,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXIII	202774	204103	202774	204103	-	YMD8	YML038C		202774,	204103,	Putative nucleotide sugar transporter, has similarity to Vrg4p
chrXIII	204385	205408	204385	205408	-	YML037C	YML037C		204385,	205408,	Putative protein of unknown function with some characteristics of a transcriptional activator  may be a target of Dbf2p-Mob1p kinase  GFP-fusion protein co-localizes with clathrin-coated vesicles  YML037C is not an essential gene
chrXIII	205641	206293	205641	206293	+	CGI121	YML036W		205641,206203,	206097,206293,	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p  EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription  Cgi121p is dispensable for tRNA modification
chrXIII	206427	208860	206427	208860	-	AMD1	YML035C		206427,	208860,	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia  may be involved in regulation of intracellular adenine nucleotide pools
chrXIII	209427	209826	209427	209826	-	YML034C-A	YML034C-A		209427,	209826,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	209524	212155	209524	212155	+	SRC1	YML034W		209524,211570,	211444,212155,	Inner nuclear membrane protein  functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors  SRC1 produces 2 splice variant proteins with different functions  alternative splicing of SRC1 pre-mRNA is promoted by Hub1p  mutant has aneuploidy tolerance
chrXIII	212514	213930	212514	213930	-	RAD52	YML032C		212514,	213930,	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA  anneals complementary single-stranded DNA  involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
chrXIII	214085	214421	214085	214421	-	YML031C-A	YML031C-A		214085,	214421,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF NDC1/YML031W  questionable ORF from MIPS
chrXIII	214188	216156	214188	216156	+	NDC1	YML031W		214188,	216156,	Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication  required for meiosis II
chrXIII	216434	216914	216434	216914	+	AIM31	YML030W		216434,	216914,	Putative protein of unknown function  GFP-fusion protein localizes to mitochondria  may interact with respiratory chain complexes III or IV  null mutant is viable and displays reduced frequency of mitochondrial genome loss
chrXIII	217361	219878	217361	219878	+	USA1	YML029W		217361,	219878,	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization  involved in ER-associated protein degradation (ERAD)  interacts with the U1 snRNP-specific protein, Snp1p
chrXIII	220137	220728	220137	220728	+	TSA1	YML028W		220137,	220728,	Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant  self-associates to form a high-molecular weight chaperone complex under oxidative stress  deletion results in mutator phenotype
chrXIII	221405	222563	221405	222563	+	YOX1	YML027W		221405,	222563,	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase  expression is cell cycle-regulated  potential Cdc28p substrate
chrXIII	222986	223828	222986	223828	-	RPS18B	YML026C		222986,223781,	223380,223828,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
chrXIII	224405	225365	224405	225365	-	YML6	YML025C		224405,225338,	225239,225365,	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein  essential for viability, unlike most other mitoribosomal proteins
chrXIII	225888	226697	225888	226697	+	RPS17A	YML024W		225888,226289,	225891,226697,	Ribosomal protein 51 (rp51) of the small (40s) subunit  nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
chrXIII	226993	228664	226993	228664	-	NSE5	YML023C		226993,	228664,	Essential subunit of the Mms21-Smc5-Smc6 complex  required for cell viability and DNA repair
chrXIII	228936	229500	228936	229500	+	APT1	YML022W		228936,	229500,	Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate  involved in the salvage pathway of purine nucleotide biosynthesis
chrXIII	229733	230813	229733	230813	-	UNG1	YML021C		229733,	230813,	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
chrXIII	231148	233143	231148	233143	+	YML020W	YML020W		231148,	233143,	Putative protein of unknown function
chrXIII	233456	234455	233456	234455	+	OST6	YML019W		233456,	234455,	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins  similar to and partially functionally redundant with Ost3p
chrXIII	234770	235952	234770	235952	-	YML018C	YML018C		234770,	235952,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole  physical interaction with Atg27p suggests a possible role in autophagy  YML018C is not an essential gene
chrXIII	236587	238731	236587	238731	+	PSP2	YML017W		236587,236953,	236591,238731,	Asn rich cytoplasmic protein that contains RGG motifs  high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha)  possible role in mitochondrial mRNA splicing
chrXIII	239457	241536	239457	241536	-	PPZ1	YML016C		239457,	241536,	Serine/threonine protein phosphatase Z, isoform of Ppz2p  involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
chrXIII	241988	243029	241988	243029	-	TAF11	YML015C		241988,	243029,	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
chrXIII	243224	244064	243224	244064	+	TRM9	YML014W		243224,	244064,	tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p  deletion confers resistance to zymocin
chrXIII	244148	245903	244148	245903	+	UBX2	YML013W		244148,	245903,	Protein involved in ER-associated protein degradation  proposed to coordinate the assembly of proteins involved in ERAD  contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain
chrXIII	245536	245914	245536	245914	-	YML012C-A	YML012C-A		245536,	245914,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene SEL1
chrXIII	246115	246751	246115	246751	+	ERV25	YML012W		246115,	246751,	Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
chrXIII	246894	247428	246894	247428	-	RAD33	YML011C		246894,	247428,	Protein involved in nucleotide excision repair  green fluorescent protein (GFP)-fusion protein localizes to the nucleus
chrXIII	247676	250868	247676	250868	+	SPT5	YML010W		247676,	250868,	Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing  forms a complex with Spt4p  contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p
chrXIII	250434	250911	250434	250911	+	YML009W-B	YML009W-B		250434,	250911,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data  deletion mutation confers an increase in Ty1 transposition
chrXIII	250674	251001	250674	251001	-	YML009C-A	YML009C-A		250674,	251001,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	251303	251516	251303	251516	-	MRPL39	YML009C		251303,	251516,	Mitochondrial ribosomal protein of the large subunit
chrXIII	251838	252990	251838	252990	-	ERG6	YML008C		251838,	252990,	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24  localized to both lipid particles and mitochondrial outer membrane
chrXIII	253161	253272	253161	253272	-	YML007C-A	YML007C-A		253161,	253272,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria
chrXIII	253847	255800	253847	255800	+	YAP1	YML007W		253847,	255800,	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance  activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus  mediates resistance to cadmium
chrXIII	256091	258416	256091	258416	-	GIS4	YML006C		256091,	258416,	CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
chrXIII	260220	261609	260220	261609	+	TRM12	YML005W		260220,	261609,	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family  required for wybutosine formation in phenylalanine-accepting tRNA
chrXIII	261704	262685	261704	262685	-	GLO1	YML004C		261704,	262685,	Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione  expression regulated by methylglyoxal levels and osmotic stress
chrXIII	263482	264355	263482	264355	+	YML003W	YML003W		263482,	264355,	Putative protein of unknown function
chrXIII	264540	266754	264540	266754	+	YML002W	YML002W		264540,	266754,	Putative protein of unknown function  expression induced by heat and by calcium shortage
chrXIII	267173	267800	267173	267800	+	YPT7	YML001W		267173,	267800,	Rab family GTPase  GTP-binding protein of the rab family  required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
chrXIII	269018	271136	269018	271136	-	CDC5	YMR001C		269018,	271136,	Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis  has similarity to Xenopus Plx1 and S. pombe Plo1p  possible Cdc28p substrate
chrXIII	271346	271577	271346	271577	-	YMR001C-A	YMR001C-A		271346,	271577,	Putative protein of unknown function
chrXIII	272192	272663	272192	272663	+	MIC17	YMR002W		272192,	272663,	Mitochondrial intermembrane space protein, required for normal oxygen consumption  contains twin cysteine-x9-cysteine motifs
chrXIII	273117	273714	273117	273714	+	AIM34	YMR003W		273117,	273714,	Protein of unknown function  GFP-fusion protein localizes to the mitochondria  null mutant is viable and displays reduced frequency of mitochondrial genome loss
chrXIII	274016	275552	274016	275552	+	MVP1	YMR004W		274016,	275552,	Protein required for sorting proteins to the vacuole  overproduction of Mvp1p suppresses several dominant VPS1 mutations  Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole
chrXIII	276044	277211	276044	277211	+	TAF4	YMR005W		276044,	277211,	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation  potential Cdc28p substrate
chrXIII	277560	279681	277560	279681	-	PLB2	YMR006C		277560,	279681,	Phospholipase B (lysophospholipase) involved in phospholipid metabolism  displays transacylase activity in vitro  overproduction confers resistance to lysophosphatidylcholine
chrXIII	279959	280340	279959	280340	+	YMR007W	YMR007W		279959,	280340,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIII	280589	282584	280589	282584	-	PLB1	YMR008C		280589,	282584,	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
chrXIII	284101	284641	284101	284641	+	ADI1	YMR009W		284101,	284641,	Acireductone dioxygenease involved in the methionine salvage pathway  ortholog of human MTCBP-1  transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage  ADI1 mRNA is induced in heat shock conditions
chrXIII	285099	286317	285099	286317	+	YMR010W	YMR010W		285099,	286317,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YMR010W is not an essential gene  YMR010W mRNA is transcribed with ADI1
chrXIII	288078	289704	288078	289704	+	HXT2	YMR011W		288078,	289704,	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
chrXIII	291133	294967	291133	294967	+	CLU1	YMR012W		291133,	294967,	eIF3 component of unknown function  deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
chrXIII	295178	296738	295178	296738	-	SEC59	YMR013C		295178,	296738,	Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis  required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
chrXIII	296470	296620	296470	296620	-	YMR013C-A	YMR013C-A		296470,	296620,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF SEC59/YML013C
chrXIII	298310	298391	298310	298391	+	YMR013W-A	YMR013W-A		298310,	298391,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the characterized snoRNA gene snR73
chrXIII	298867	300427	298867	300427	+	BUD22	YMR014W		298867,	300427,	Protein required for 18S rRNA maturation and small ribosomal subunit biogenesis  cosediments with pre-ribosomal particles  mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern
chrXIII	300868	302485	300868	302485	-	ERG5	YMR015C		300868,	302485,	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis  may be a target of azole antifungal drugs
chrXIII	303235	305593	303235	305593	-	SOK2	YMR016C		303235,	305593,	Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway  negatively regulates pseudohyphal differentiation  homologous to several transcription factors
chrXIII	307488	308682	307488	308682	+	SPO20	YMR017W		307488,	308682,	Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation  similar to but not functionally redundant with Sec9p  SNAP-25 homolog
chrXIII	310207	311752	310207	311752	+	YMR018W	YMR018W		310207,	311752,	Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein)  transcription increases during colony development similar to genes involved in peroxisome biogenesis  YMR018W is not an essential gene
chrXIII	312155	315005	312155	315005	+	STB4	YMR019W		312155,	315005,	Protein that binds Sin3p in a two-hybrid assay  contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins  computational analysis suggests a role in regulation of expression of genes encoding transporters
chrXIII	315376	316903	315376	316903	+	FMS1	YMR020W		315376,	316903,	Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A  also involved in pantothenic acid biosynthesis
chrXIII	317164	318418	317164	318418	-	MAC1	YMR021C		317164,	318418,	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
chrXIII	318679	319177	318679	319177	+	UBC7	YMR022W		318679,	319177,	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway  requires Cue1p for recruitment to the ER membrane  proposed to be involved in chromatin assembly
chrXIII	319436	321017	319436	321017	-	MSS1	YMR023C		319436,	321017,	Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs  similar to human GTPBP3
chrXIII	321874	323047	321874	323047	+	MRPL3	YMR024W		321874,	323047,	Mitochondrial ribosomal protein of the large subunit
chrXIII	323299	324187	323299	324187	+	CSI1	YMR025W		323299,	324187,	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin)  involved in adaptation to pheromone signaling
chrXIII	324235	325435	324235	325435	-	PEX12	YMR026C		324235,	325435,	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import  forms translocation subcomplex with Pex2p and Pex10p  mutations in human homolog cause peroxisomal disorder
chrXIII	325876	327289	325876	327289	+	YMR027W	YMR027W		325876,	327289,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm  YMR027W is not an essential gene
chrXIII	327481	328582	327481	328582	+	TAP42	YMR028W		327481,	328582,	Essential protein involved in the TOR signaling pathway  physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
chrXIII	328659	330231	328659	330231	-	FAR8	YMR029C		328659,	330231,	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway  interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
chrXIII	330792	331923	330792	331923	+	RSF1	YMR030W		330792,	331923,	Protein required for respiratory growth  localized to both the nucleus and mitochondrion  may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
chrXIII	332211	334743	332211	334743	-	YMR031C	YMR031C		332211,	334743,	Component of the eisosome that is required for proper eisosome assembly  similarity to Ykl050cp and Uso1p  the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
chrXIII	334708	335035	334708	335035	+	YMR031W-A	YMR031W-A		334708,	335035,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  null mutant displays shortened telomeres  partially overlaps the uncharacterized ORF YMR031C
chrXIII	335297	337307	335297	337307	+	HOF1	YMR032W		335297,	337307,	Bud neck-localized, SH3 domain-containing protein required for cytokinesis  regulates actomyosin ring dynamics and septin localization  interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
chrXIII	337312	337603	337312	337603	+	YMR030W-A	YMR030W-A		337312,	337603,	Putative protein of unknown function
chrXIII	337787	339277	337787	339277	+	ARP9	YMR033W		337787,337903,	337817,339277,	Component of both the SWI/SNF and RSC chromatin remodeling complexes  actin-related protein involved in transcriptional regulation
chrXIII	339417	340722	339417	340722	-	YMR034C	YMR034C		339417,	340722,	Putative transporter, member of the SLC10 carrier family  identified in a transposon mutagenesis screen as a gene involved in azole resistance  YMR034C is not an essential gene
chrXIII	341141	341675	341141	341675	+	IMP2	YMR035W		341141,	341675,	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space  complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
chrXIII	341855	343520	341855	343520	-	MIH1	YMR036C		341855,	343520,	Protein tyrosine phosphatase involved in cell cycle control  regulates the phosphorylation state of Cdc28p  homolog of S. pombe cdc25
chrXIII	344402	346517	344402	346517	-	MSN2	YMR037C		344402,	346517,	Transcriptional activator related to Msn4p  activated in stress conditions, which results in translocation from the cytoplasm to the nucleus  binds DNA at stress response elements of responsive genes, inducing gene expression
chrXIII	347510	348260	347510	348260	-	CCS1	YMR038C		347510,	348260,	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection  Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
chrXIII	348643	349522	348643	349522	-	SUB1	YMR039C		348643,	349522,	Transcriptional coactivator, facilitates elongation through factors that modify RNAP II  role in peroxide resistance involving Rad2p  role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes
chrXIII	350380	350863	350380	350863	+	YET2	YMR040W		350380,	350863,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  homolog of human BAP31 protein
chrXIII	350965	351973	350965	351973	-	ARA2	YMR041C		350965,	351973,	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone  similar to plant L-galactose dehydrogenase
chrXIII	352602	353136	352602	353136	+	ARG80	YMR042W		352602,	353136,	Transcription factor involved in regulation of arginine-responsive genes  acts with Arg81p and Arg82p
chrXIII	353870	354731	353870	354731	+	MCM1	YMR043W		353870,	354731,	Transcription factor involved in cell-type-specific transcription and pheromone response  plays a central role in the formation of both repressor and activator complexes
chrXIII	355383	356811	355383	356811	+	IOC4	YMR044W		355383,	356811,	Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif
chrXIII	357358	362627	357358	362627	-	YMR045C	YMR045C		357358,361322,	361321,362627,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXIII	361304	362627	361304	362627	-	YMR046C	YMR046C		361304,	362627,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXIII	362701	362830	362701	362830	+	YMR046W-A	YMR046W-A		362701,	362830,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	363363	366705	363363	366705	-	NUP116	YMR047C		363363,	366705,	Subunit of the Nup82 subcomplex of the nuclear pore complex  localized to both sides of the pore  contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p  homologous to Nup100p
chrXIII	366980	367934	366980	367934	+	CSM3	YMR048W		366980,	367934,	Replication fork associated factor, required for stable replication fork pausing  component of the DNA replication checkpoint pathway  required for accurate chromosome segregation during meiosis
chrXIII	368093	370517	368093	370517	-	ERB1	YMR049C		368093,	370517,	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit  required for maturation of the 25S and 5.8S ribosomal RNAs  homologous to mammalian Bop1
chrXIII	373056	378325	373056	378325	-	YMR050C	YMR050C		373056,377020,	377019,378325,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXIII	377002	378325	377002	378325	-	YMR051C	YMR051C		377002,	378325,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXIII	379585	380200	379585	380200	+	FAR3	YMR052W		379585,	380200,	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway  interacts with Far7p, Far8p, Far9p, Far10p, and Far11p  localizes to the endoplasmic reticulum
chrXIII	380068	380434	380068	380434	-	YMR052C-A	YMR052C-A		380068,	380434,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	380345	382898	380345	382898	-	STB2	YMR053C		380345,	382898,	Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
chrXIII	383302	385975	383302	385975	+	STV1	YMR054W		383302,	385975,	Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p)  Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
chrXIII	386100	387021	386100	387021	-	BUB2	YMR055C		386100,	387021,	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
chrXIII	387314	388244	387314	388244	-	AAC1	YMR056C		387314,	388244,	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP  phosphorylated  Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
chrXIII	388358	388730	388358	388730	-	YMR057C	YMR057C		388358,	388730,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF AAC1
chrXIII	388821	390732	388821	390732	+	FET3	YMR058W		388821,	390732,	Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
chrXIII	391098	391485	391098	391485	+	SEN15	YMR059W		391098,	391485,	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
chrXIII	391531	392515	391531	392515	-	SAM37	YMR060C		391531,	392515,	Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion  contributes to SAM complex stability
chrXIII	392754	394788	392754	394788	+	RNA14	YMR061W		392754,	394788,	Cleavage and polyadenylation factor I (CF I) component  involved in cleavage and polyadenylation of mRNA 3' ends  bridges interaction between Rna15p and Hrp1p in the CF I complex  mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
chrXIII	395053	396379	395053	396379	-	ARG7	YMR062C		395053,	396379,	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis  also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
chrXIII	397076	397796	397076	397796	+	RIM9	YMR063W		397076,	397796,	Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH  has similarity to A. nidulans PalI  putative membrane protein
chrXIII	397902	399459	397902	399459	+	AEP1	YMR064W		397902,	399459,	Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
chrXIII	399701	401216	399701	401216	+	KAR5	YMR065W		399701,	401216,	Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p  expression of the gene is regulated by pheromone
chrXIII	401540	404237	401540	404237	+	SOV1	YMR066W		401540,	404237,	Mitochondrial protein of unknown function
chrXIII	404322	405573	404322	405573	-	UBX4	YMR067C		404322,	405573,	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
chrXIII	406303	407584	406303	407584	+	AVO2	YMR068W		406303,	407584,	Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
chrXIII	407708	408566	407708	408566	+	NAT4	YMR069W		407708,	408566,	N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
chrXIII	409153	410626	409153	410626	+	MOT3	YMR070W		409153,	410626,	Nuclear transcription factor with two Cys2-His2 zinc fingers  involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes  can form the [MOT3+] prion
chrXIII	410761	411265	410761	411265	-	TVP18	YMR071C		410761,	411265,	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p  may interact with ribosomes, based on co-purification experiments
chrXIII	411568	412120	411568	412120	+	ABF2	YMR072W		411568,	412120,	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family  activity may be regulated by protein kinase A phosphorylation
chrXIII	412267	412873	412267	412873	-	IRC21	YMR073C		412267,	412873,	Putative protein of unknown function  may be involved in resistance to carboplatin and cisplatin  null mutant displays increase in spontaneous Rad52p foci  contains a lipid-binding domain and binds cardiolipin in a large-scale study
chrXIII	413035	413473	413035	413473	-	YMR074C	YMR074C		413035,	413473,	Protein with homology to human PDCD5, which is involved in programmed cell death  N-terminal region forms a conserved triple-helix bundle structure  overexpression promotes H2O2-induced apoptosis  YMR074C is not an essential gene
chrXIII	413981	416036	413981	416036	+	RCO1	YMR075W		413981,	416036,	Essential subunit of the histone deacetylase Rpd3S complex  interacts with Eaf3p
chrXIII	415687	416053	415687	416053	-	YMR075C-A	YMR075C-A		415687,	416053,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF RCO1/YMR075W
chrXIII	416195	420029	416195	420029	-	PDS5	YMR076C		416195,	420029,	Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold  also required during meiosis
chrXIII	421483	422149	421483	422149	-	VPS20	YMR077C		421483,	422149,	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen  cytoplasmic protein recruited to endosomal membranes
chrXIII	422502	424728	422502	424728	-	CTF18	YMR078C		422502,	424728,	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion  may have overlapping functions with Rad24p in the DNA damage replication checkpoint
chrXIII	424988	426059	424988	426059	+	SEC14	YMR079W		424988,425153,	424997,426059,	Phosphatidylinositol/phosphatidylcholine transfer protein  involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR  functionally homologous to mammalian PITPs
chrXIII	426711	429627	426711	429627	-	NAM7	YMR080C		426711,	429627,	ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay  required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies  involved in telomere maintenance
chrXIII	430078	431095	430078	431095	-	ISF1	YMR081C		430078,	431095,	Serine-rich, hydrophilic protein with similarity to Mbr1p  overexpression suppresses growth defects of hap2, hap3, and hap4 mutants  expression is under glucose control  cotranscribed with NAM7 in a cyp1 mutant
chrXIII	431768	432125	431768	432125	-	YMR082C	YMR082C		431768,	432125,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	434787	435915	434787	435915	+	ADH3	YMR083W		434787,	435915,	Mitochondrial alcohol dehydrogenase isozyme III  involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
chrXIII	436627	437416	436627	437416	+	YMR084W	YMR084W		436627,	437416,	Putative protein of unknown function  YMR084W and adjacent ORF YMR085W are merged in related strains
chrXIII	437490	438789	437490	438789	+	YMR085W	YMR085W		437490,	438789,	Putative protein of unknown function  YMR085W and adjacent ORF YMR084W are merged in related strains
chrXIII	439207	442090	439207	442090	+	YMR086W	YMR086W		439207,	442090,	Component of the eisosome with unknown function  may interact with ribosomes, based on co-purification experiments  GFP-fusion protein localizes to the cell periphery  expression is repressed by cAMP  similar to A. gossypii SEG gene which is important for stabilizing eisosomes
chrXIII	442025	442364	442025	442364	-	YMR086C-A	YMR086C-A		442025,	442364,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	442526	443381	442526	443381	+	YMR087W	YMR087W		442526,	443381,	Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose  may have a role in tRNA splicing  contains an A1pp domain
chrXIII	443413	445102	443413	445102	-	VBA1	YMR088C		443413,	445102,	Permease of basic amino acids in the vacuolar membrane
chrXIII	445608	448086	445608	448086	-	YTA12	YMR089C		445608,	448086,	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
chrXIII	449244	449928	449244	449928	+	YMR090W	YMR090W		449244,	449928,	Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases  GFP-fusion protein localizes to the cytoplasm  up-regulated in response to the fungicide mancozeb  not essential for viability
chrXIII	450057	451365	450057	451365	-	NPL6	YMR091C		450057,	451365,	Component of the RSC chromatin remodeling complex  interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions  involved in nuclear protein import and maintenance of proper telomere length
chrXIII	451631	453479	451631	453479	-	AIP1	YMR092C		451631,	453479,	Actin cortical patch component, interacts with the actin depolymerizing factor cofilin  required to restrict cofilin localization to cortical patches  contains WD repeats
chrXIII	454014	455556	454014	455556	+	UTP15	YMR093W		454014,	455556,	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
chrXIII	455824	457261	455824	457261	+	CTF13	YMR094W		455824,	457261,	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
chrXIII	457284	457959	457284	457959	-	SNO1	YMR095C		457284,	457959,	Protein of unconfirmed function, involved in pyridoxine metabolism  expression is induced during stationary phase  forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
chrXIII	458407	459301	458407	459301	+	SNZ1	YMR096W		458407,	459301,	Protein involved in vitamin B6 biosynthesis  member of a stationary phase-induced gene family  coregulated with SNO1  interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
chrXIII	459423	460527	459423	460527	-	MTG1	YMR097C		459423,	460527,	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
chrXIII	460770	462609	460770	462609	-	ATP25	YMR098C		460770,	462609,	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation  YMR098C is not an essential gene
chrXIII	463933	464827	463933	464827	-	YMR099C	YMR099C		463933,	464827,	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism  GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
chrXIII	466299	468162	466299	468162	+	MUB1	YMR100W		466299,	468162,	MYND domain-containing protein required for ubiquitination and turnover of Rpn4p  interacts with Ubr2p (E3) and indirectly with Rad6p (E2)  short-lived protein degraded in a Ubr2p/Rad6p dependent manner  similar to the A. nidulans samB gene
chrXIII	468444	469476	468444	469476	-	SRT1	YMR101C		468444,	469476,	Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units  as opposed to Rer2p which synthesizes shorter-chain dolichols)  localizes to lipid bodies  transcription is induced during stationary phase
chrXIII	469847	472352	469847	472352	-	YMR102C	YMR102C		469847,	472352,	Protein of unknown function  transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance  mutant shows increased resistance to azoles  YMR102C is not an essential gene
chrXIII	472901	473264	472901	473264	-	YMR103C	YMR103C		472901,	473264,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIII	473419	475453	473419	475453	-	YPK2	YMR104C		473419,	475453,	Protein kinase with similarity to serine/threonine protein kinase Ypk1p  functionally redundant with YPK1 at the genetic level  participates in a signaling pathway required for optimal cell wall integrity  homolog of mammalian kinase SGK
chrXIII	475896	477606	475896	477606	-	PGM2	YMR105C		475896,	477606,	Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism  functions as the acceptor for a Glc-phosphotransferase
chrXIII	478063	478258	478063	478258	+	YMR105W-A	YMR105W-A		478063,	478258,	Putative protein of unknown function
chrXIII	478300	480190	478300	480190	-	YKU80	YMR106C		478300,	480190,	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect  relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
chrXIII	483013	483361	483013	483361	+	SPG4	YMR107W		483013,	483361,	Protein required for survival at high temperature during stationary phase  not required for growth on nonfermentable carbon sources
chrXIII	484083	486147	484083	486147	+	ILV2	YMR108W		484083,	486147,	Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria  expression of the gene is under general amino acid control
chrXIII	486586	490246	486586	490246	+	MYO5	YMR109W		486586,	490246,	One of two type I myosins  contains proline-rich tail homology 2 (TH2) and SH3 domains  MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
chrXIII	490393	491992	490393	491992	-	HFD1	YMR110C		490393,	491992,	Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles  has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
chrXIII	492403	493792	492403	493792	-	YMR111C	YMR111C		492403,	493792,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus  YMR111C is not an essential gene
chrXIII	494099	494495	494099	494495	-	MED11	YMR112C		494099,	494495,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential protein
chrXIII	494998	496282	494998	496282	+	FOL3	YMR113W		494998,	496282,	Dihydrofolate synthetase, involved in folic acid biosynthesis  catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
chrXIII	496342	497449	496342	497449	-	YMR114C	YMR114C		496342,	497449,	Protein of unknown function  may interact with ribosomes, based on co-purification experiments  green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm  YMR114C is not an essential gene
chrXIII	497703	499209	497703	499209	+	MGR3	YMR115W		497703,	499209,	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins  forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis  required for growth of cells lacking mtDNA
chrXIII	499455	500688	499455	500688	-	ASC1	YMR116C		499455,500151,	499878,500688,	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p  ortholog of RACK1 that inhibits translation  core component of the small (40S) ribosomal subunit  represses Gcn4p in the absence of amino acid starvation
chrXIII	501249	501891	501249	501891	-	SPC24	YMR117C		501249,	501891,	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p)  involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
chrXIII	502143	502734	502143	502734	-	YMR118C	YMR118C		502143,	502734,	Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit  YMR118C is not an essential gene
chrXIII	505332	507207	505332	507207	+	ASI1	YMR119W		505332,	507207,	Putative integral membrane E3 ubiquitin ligase  acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
chrXIII	506995	507370	506995	507370	+	YMR119W-A	YMR119W-A		506995,	507370,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	507501	509280	507501	509280	-	ADE17	YMR120C		507501,	509280,	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p  ade16 ade17 mutants require adenine and histidine
chrXIII	509733	510348	509733	510348	-	RPL15B	YMR121C		509733,	510348,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein  binds to 5.8 S rRNA
chrXIII	510700	511075	510700	511075	-	YMR122C	YMR122C		510700,	511075,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	511314	511569	511314	511569	+	YMR122W-A	YMR122W-A		511314,	511569,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
chrXIII	513592	513961	513592	513961	+	PKR1	YMR123W		513592,	513961,	V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0)
chrXIII	514455	517287	514455	517287	+	YMR124W	YMR124W		514455,	517287,	Protein of unknown function  GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck  interacts with Crm1p in two-hybrid assay  YMR124W is not an essential gene  predicted to have a role in organelle organization
chrXIII	517538	520446	517538	520446	+	STO1	YMR125W		517538,517885,	517563,520446,	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm  also involved in nuclear mRNA degradation and telomere maintenance  orthologous to mammalian CBP80
chrXIII	520760	521789	520760	521789	-	DLT1	YMR126C		520760,	521789,	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
chrXIII	522328	523345	522328	523345	-	SAS2	YMR127C		522328,	523345,	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing  member of the MYSTacetyltransferase family
chrXIII	523695	527499	523695	527499	+	ECM16	YMR128W		523695,	527499,	Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
chrXIII	527803	531817	527803	531817	+	POM152	YMR129W		527803,	531817,	Nuclear pore membrane glycoprotein  may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase
chrXIII	532118	533027	532118	533027	+	YMR130W	YMR130W		532118,	533027,	Putative protein of unknown function  YMR130W is not an essential gene
chrXIII	533162	534698	533162	534698	-	RRB1	YMR131C		533162,	534698,	Essential nuclear protein involved in early steps of ribosome biogenesis  physically interacts with the ribosomal protein Rpl3p
chrXIII	534943	535570	534943	535570	-	JLP2	YMR132C		534943,	535570,	Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
chrXIII	536206	537609	536206	537609	+	REC114	YMR133W		536206,537564,	537448,537609,	Protein involved in early stages of meiotic recombination  possibly involved in the coordination of recombination and meiotic division  mutations lead to premature initiation of the first meiotic division
chrXIII	537837	538551	537837	538551	+	YMR134W	YMR134W		537837,	538551,	Protein of unknown function that may be involved in iron metabolism  mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p  shows localization to the ER  highly conserved in ascomycetes
chrXIII	538688	540056	538688	540056	-	GID8	YMR135C		538688,	540056,	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase  contains LisH and CTLH domains, like Vid30p  dosage-dependent regulator of START
chrXIII	539910	540444	539910	540444	+	YMR135W-A	YMR135W-A		539910,	540444,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	541198	542881	541198	542881	+	GAT2	YMR136W		541198,	542881,	Protein containing GATA family zinc finger motifs  similar to Gln3p and Dal80p  expression repressed by leucine
chrXIII	542977	544963	542977	544963	-	PSO2	YMR137C		542977,	544963,	Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives  induced by UV-irradiation
chrXIII	545154	545730	545154	545730	+	CIN4	YMR138W		545154,	545730,	GTP-binding protein involved in beta-tubulin (Tub2p) folding  isolated as mutant with increased chromosome loss and sensitivity to benomyl  regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
chrXIII	546124	547237	546124	547237	+	RIM11	YMR139W		546124,	547237,	Protein kinase required for signal transduction during entry into meiosis  promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p  shares similarity with mammalian glycogen synthase kinase 3-beta
chrXIII	547713	549183	547713	549183	+	SIP5	YMR140W		547713,	549183,	Protein of unknown function  interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase
chrXIII	549735	550044	549735	550044	-	YMR141C	YMR141C		549735,	550044,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	550205	551207	550205	551207	-	RPL13B	YMR142C		550205,551203,	550801,551207,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap  not essential for viability  has similarity to rat L13 ribosomal protein
chrXIII	550910	551135	550910	551135	+	YMR141W-A	YMR141W-A		550910,	551135,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene RPL13B/YMR142C
chrXIII	551927	552903	551927	552903	+	RPS16A	YMR143W		551927,552495,	551951,552903,	Protein component of the small (40S) ribosomal subunit  identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
chrXIII	553361	554390	553361	554390	+	YMR144W	YMR144W		553361,	554390,	Putative protein of unknown function  localized to the nucleus  YMR144W is not an essential gene
chrXIII	554792	556475	554792	556475	-	NDE1	YMR145C		554792,	556475,	Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH  Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
chrXIII	557480	558524	557480	558524	-	TIF34	YMR146C		557480,	558524,	eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation  stimulates rate of ribosomal scanning during translation reinitiation
chrXIII	559198	559870	559198	559870	+	YMR147W	YMR147W		559198,	559870,	Putative protein of unknown function
chrXIII	560365	560812	560365	560812	+	OSW5	YMR148W		560365,	560812,	Protein of unknown function that may play a role in spore wall assembly  predicted to contain an N-terminal transmembrane domain  osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
chrXIII	560995	561856	560995	561856	+	SWP1	YMR149W		560995,	561856,	Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
chrXIII	561955	562528	561955	562528	-	IMP1	YMR150C		561955,	562528,	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space  complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
chrXIII	562505	562943	562505	562943	+	YIM2	YMR151W		562505,	562943,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  5% of ORF overlaps the verified gene IMP1
chrXIII	563095	564193	563095	564193	+	YIM1	YMR152W		563095,	564193,	Protein of unknown function  null mutant displays sensitivity to DNA damaging agents  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIII	564434	565862	564434	565862	+	NUP53	YMR153W		564434,	565862,	Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex
chrXIII	565573	565909	565573	565909	-	YMR153C-A	YMR153C-A		565573,	565909,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene NUP53
chrXIII	565998	568182	565998	568182	-	RIM13	YMR154C		565998,	568182,	Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH  has similarity to A. nidulans palB
chrXIII	568550	570194	568550	570194	+	YMR155W	YMR155W		568550,	570194,	Putative protein of unknown function  identified as interacting with Hsp82p in a high-throughput two-hybrid screen
chrXIII	570299	571016	570299	571016	-	TPP1	YMR156C		570299,	571016,	DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks  has similarity to the l-2-haloacid dehalogenase superfamily
chrXIII	571276	572044	571276	572044	-	AIM36	YMR157C		571276,	572044,	Protein of unknown function  null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss  the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
chrXIII	572247	572715	572247	572715	+	MRPS8	YMR158W		572247,	572715,	Mitochondrial ribosomal protein of the small subunit
chrXIII	573193	573331	573193	573331	-	YMR158C-A	YMR158C-A		573193,	573331,	Putative protein of unknown function, may contain a lipid attachment site  YMR158C-A is not an essential gene
chrXIII	574470	574791	574470	574791	+	YMR158W-B	YMR158W-B		574470,	574791,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene ATG16/YMR159C
chrXIII	574475	574928	574475	574928	-	ATG16	YMR159C		574475,	574928,	Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy
chrXIII	575065	577516	575065	577516	+	YMR160W	YMR160W		575065,	577516,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole  mutant has enhanced sensitivity to overexpression of mutant huntingtin  YMR160W is not an essential gene
chrXIII	577717	578392	577717	578392	+	HLJ1	YMR161W		577717,	578392,	Co-chaperone for Hsp40p, anchored in the ER membrane  with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates  similar to E. coli DnaJ
chrXIII	578950	583921	578950	583921	-	DNF3	YMR162C		578950,	583921,	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles  localizes to the trans-Golgi network  likely involved in protein transport  type 4 P-type ATPase
chrXIII	584270	586388	584270	586388	-	INP2	YMR163C		584270,	586388,	Peroxisome-specific receptor important for peroxisome inheritance  co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo  physically interacts with the myosin V motor Myo2p  INP2 is not an essential gene
chrXIII	587273	589550	587273	589550	-	MSS11	YMR164C		587273,	589550,	Transcription factor involved in regulation of invasive growth and starch degradation  controls the activation of MUC1 and STA2 in response to nutritional signals
chrXIII	590039	592628	590039	592628	-	PAH1	YMR165C		590039,	592628,	Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol, responsible for de novo lipid synthesis and formation of lipid droplets  homologous to mammalian lipin 1
chrXIII	593366	594473	593366	594473	-	YMR166C	YMR166C		593366,	594473,	Predicted transporter of the mitochondrial inner membrane  has similarity to human mitochondrial ATP-Mg/Pi carriers  YMR166C is not an essential gene
chrXIII	594885	597195	594885	597195	+	MLH1	YMR167W		594885,	597195,	Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis  forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair  human homolog is associated with hereditary non-polyposis colon cancer
chrXIII	597331	599158	597331	599158	-	CEP3	YMR168C		597331,	599158,	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere  contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
chrXIII	599351	600872	599351	600872	-	ALD3	YMR169C		599351,	600872,	Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis  uses NAD+ as the preferred coenzyme  very similar to Ald2p  expression is induced by stress and repressed by glucose
chrXIII	601561	603082	601561	603082	-	ALD2	YMR170C		601561,	603082,	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis  uses NAD+ as the preferred coenzyme  expression is stress induced and glucose repressed  very similar to Ald3p
chrXIII	603867	605520	603867	605520	-	EAR1	YMR171C		603867,	605520,	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body  mRNA is targeted to the bud via the mRNA transport system involving She2p
chrXIII	605980	608140	605980	608140	+	HOT1	YMR172W		605980,	608140,	Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity  targets Hog1p to osmostress responsive promoters  has similarity to Msn1p and Gcr1p
chrXIII	607827	608211	607827	608211	-	YMR172C-A	YMR172C-A		607827,	608211,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIII	608688	609981	608688	609981	+	DDR48	YMR173W		608688,	609981,	DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions  contains multiple repeats of the amino acid sequence NNNDSYGS
chrXIII	608896	610081	608896	610081	+	YMR173W-A	YMR173W-A		608896,	610081,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene DDR48/YML173W
chrXIII	610158	610365	610158	610365	-	PAI3	YMR174C		610158,	610365,	Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction  intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
chrXIII	611015	611255	611015	611255	+	SIP18	YMR175W		611015,	611255,	Phospholipid-binding hydrophilin with a role in dessication resistance  expression is induced by osmotic stress
chrXIII	611313	611508	611313	611508	+	YMR175W-A	YMR175W-A		611313,	611508,	Putative protein of unknown function
chrXIII	611739	615975	611739	615975	+	ECM5	YMR176W		611739,	615975,	Non-essential protein of unknown function, contains ATP/GTP-binding site motif A  null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks
chrXIII	616565	618098	616565	618098	+	MMT1	YMR177W		616565,	618098,	Putative metal transporter involved in mitochondrial iron accumulation  closely related to Mmt2p
chrXIII	618478	619303	618478	619303	+	YMR178W	YMR178W		618478,	619303,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS  YMR178W is not an essential gene
chrXIII	619857	622134	619857	622134	+	SPT21	YMR179W		619857,	622134,	Protein with a role in transcriptional silencing  required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci  functionally related to Spt10p
chrXIII	622250	623213	622250	623213	-	CTL1	YMR180C		622250,	623213,	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
chrXIII	623615	624080	623615	624080	-	YMR181C	YMR181C		623615,	624080,	Protein of unknown function  mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C  mRNA is destroyed by nonsense-mediated decay (NMD)  YMR181C is not an essential gene
chrXIII	624531	625167	624531	625167	-	RGM1	YMR182C		624531,	625167,	Putative transcriptional repressor with proline-rich zinc fingers  overproduction impairs cell growth
chrXIII	625810	625897	625810	625897	+	YMR182W-A	YMR182W-A		625810,	625897,	Putative protein of unknown function
chrXIII	626920	627808	626920	627808	-	SSO2	YMR183C		626920,	627808,	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane  syntaxin homolog that is functionally redundant with Sso1p
chrXIII	628188	628785	628188	628785	+	ADD37	YMR184W		628188,	628785,	Protein of unknown function involved in ER-associated protein degradation  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS  YMR184W is not an essential gene
chrXIII	629024	631970	629024	631970	+	YMR185W	YMR185W		629024,	631970,	Putative protein of unknown function  conflicting evidence on whether null mutant is viable with elongated buds, or inviable
chrXIII	632354	634472	632354	634472	+	HSC82	YMR186W		632354,	634472,	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential  expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
chrXIII	634688	635984	634688	635984	-	YMR187C	YMR187C		634688,	635984,	Putative protein of unknown function  YMR187C is not an essential gene
chrXIII	636290	637004	636290	637004	-	MRPS17	YMR188C		636290,	637004,	Mitochondrial ribosomal protein of the small subunit
chrXIII	637499	640604	637499	640604	+	GCV2	YMR189W		637499,	640604,	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF  expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
chrXIII	640914	645258	640914	645258	-	SGS1	YMR190C		640914,	645258,	Nucleolar DNA helicase of the RecQ family  involved in genome integrity maintenance  regulates chromosome synapsis and meiotic joint molecule/crossover formation  potential role as repressor of a subset of rapamycin responsive genes  rapidly lost in response to rapamycin in Rrd1p-dependent manner  similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes
chrXIII	645655	646777	645655	646777	+	SPG5	YMR191W		645655,	646777,	Protein required for survival at high temperature during stationary phase  not required for growth on nonfermentable carbon sources
chrXIII	647117	649280	647117	649280	+	GYL1	YMR192W		647117,	649280,	Putative GTPase activating protein (GAP) with a role in exocytosis  stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth  interacts with Gyp5p, Rvs161p, and Rvs167p  involved in recruiting Rvs167p to the bud tip during polarized growth
chrXIII	650035	650812	650035	650812	+	MRPL24	YMR193W		650035,	650812,	Mitochondrial ribosomal protein of the large subunit
chrXIII	651071	651458	651071	651458	-	YMR193C-A	YMR193C-A		651071,	651458,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	651144	651910	651144	651910	+	RPL36A	YMR194W		651144,651623,	651160,651910,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein  binds to 5.8 S rRNA
chrXIII	652593	652887	652593	652887	-	CMC4	YMR194C-B		652593,652847,	652775,652887,	Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system  contains twin cysteine-x(9)-cysteine motifs
chrXIII	652911	653136	652911	653136	-	YMR194C-A	YMR194C-A		652911,	653136,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	654033	654417	654033	654417	+	ICY1	YMR195W		654033,	654417,	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA  mutants have an invasive growth defect with elongated morphology  induced by amino acid starvation
chrXIII	655075	658342	655075	658342	+	YMR196W	YMR196W		655075,	658342,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YMR196W is not an essential gene
chrXIII	658544	659198	658544	659198	-	VTI1	YMR197C		658544,	659198,	Protein involved in cis-Golgi membrane traffic  v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p  required for multiple vacuolar sorting pathways
chrXIII	659744	661529	659744	661529	+	CIK1	YMR198W		659744,	661529,	Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role  has similarity to Vik1p
chrXIII	662643	664284	662643	664284	+	CLN1	YMR199W		662643,	664284,	G1 cyclin involved in regulation of the cell cycle  activates Cdc28p kinase to promote the G1 to S phase transition  late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
chrXIII	664751	665522	664751	665522	+	ROT1	YMR200W		664751,	665522,	Molecular chaperone involved in protein folding in the ER  mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations
chrXIII	665844	667044	665844	667044	-	RAD14	YMR201C		665844,667017,	666933,667044,	Protein that recognizes and binds damaged DNA during nucleotide excision repair  subunit of Nucleotide Excision Repair Factor 1 (NEF1)  contains zinc finger motif  homolog of human XPA protein
chrXIII	667536	668205	667536	668205	+	ERG2	YMR202W		667536,	668205,	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
chrXIII	668491	669655	668491	669655	+	TOM40	YMR203W		668491,	669655,	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins  constitutes the core element of the protein conducting pore
chrXIII	670062	671325	670062	671325	-	INP1	YMR204C		670062,	671325,	Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance  recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane
chrXIII	671886	674766	671886	674766	-	PFK2	YMR205C		671886,	674766,	Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
chrXIII	675895	676837	675895	676837	+	YMR206W	YMR206W		675895,	676837,	Putative protein of unknown function  YMR206W is not an essential gene
chrXIII	677192	683564	677192	683564	-	HFA1	YMR207C		677192,	683564,	Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis
chrXIII	684466	685798	684466	685798	+	ERG12	YMR208W		684466,	685798,	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
chrXIII	685910	687284	685910	687284	-	YMR209C	YMR209C		685910,	687284,	Putative S-adenosylmethionine-dependent methyltransferase  YMR209C is not an essential gene
chrXIII	687515	688865	687515	688865	+	YMR210W	YMR210W		687515,	688865,	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis  may be involved in lipid metabolism and detoxification
chrXIII	689082	690510	689082	690510	+	DML1	YMR211W		689082,	690510,	Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
chrXIII	690694	693043	690694	693043	-	EFR3	YMR212C		690694,	693043,	Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane  exhibits synthetic lethal genetic interactions with PHO85  has sequence similarity to the Drosophila rolling blackout (RBO) gene
chrXIII	693380	695153	693380	695153	+	CEF1	YMR213W		693380,	695153,	Essential splicing factor  associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
chrXIII	695349	696483	695349	696483	+	SCJ1	YMR214W		695349,	696483,	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
chrXIII	696795	698370	696795	698370	+	GAS3	YMR215W		696795,	698370,	Low abundance, possibly inactive member of the GAS family of GPI-containing proteins  putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members  localizes to the cell wall  mRNA induced during sporulation
chrXIII	698810	701039	698810	701039	-	SKY1	YMR216C		698810,	701039,	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis  similar to human SRPK1
chrXIII	701789	703367	701789	703367	+	GUA1	YMR217W		701789,	703367,	GMP synthase  highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP)  transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation  reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA
chrXIII	703578	706887	703578	706887	-	TRS130	YMR218C		703578,	706887,	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion  involved in ER to Golgi membrane traffic  mutation activates transcription of OCH1
chrXIII	707132	712109	707132	712109	+	ESC1	YMR219W		707132,	712109,	Protein localized to the nuclear periphery, involved in telomeric silencing  interacts with PAD4-domain of Sir4p
chrXIII	712315	713671	712315	713671	+	ERG8	YMR220W		712315,	713671,	Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
chrXIII	713930	715445	713930	715445	-	YMR221C	YMR221C		713930,	715445,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies  physical interaction with Atg27p suggests a possible role in autophagy
chrXIII	715637	716309	715637	716309	-	FSH2	YMR222C		715637,	716309,	Putative serine hydrolase that localizes to the cytoplasm  sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
chrXIII	716714	718130	716714	718130	+	UBP8	YMR223W		716714,	718130,	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex  required for SAGA-mediated deubiquitination of histone H2B
chrXIII	718574	720653	718574	720653	-	MRE11	YMR224C		718574,	720653,	Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function  widely conserved
chrXIII	720959	721403	720959	721403	-	MRPL44	YMR225C		720959,721345,	721198,721403,	Mitochondrial ribosomal protein of the large subunit
chrXIII	721592	722396	721592	722396	-	YMR226C	YMR226C		721592,	722396,	NADP(+)-dependent dehydrogenase  acts on serine, L-allo-threonine, and other 3-hydroxy acids  green fluorescent protein fusion protein localizes to the cytoplasm and nucleus  may interact with ribosomes, based on co-purification experiments
chrXIII	722612	724385	722612	724385	-	TAF7	YMR227C		722612,	724385,	TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
chrXIII	724625	725651	724625	725651	+	MTF1	YMR228W		724625,	725651,	Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
chrXIII	725933	731123	725933	731123	-	RRP5	YMR229C		725933,	731123,	RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs  component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
chrXIII	732413	733141	732413	733141	+	RPS10B	YMR230W		732413,732875,	732465,733141,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
chrXIII	733267	733456	733267	733456	+	YMR230W-A	YMR230W-A		733267,	733456,	Putative protein of unknown function
chrXIII	733544	736634	733544	736634	+	PEP5	YMR231W		733544,	736634,	Component of CORVET tethering complex  peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis  interacts with Pep7p
chrXIII	736925	738959	736925	738959	+	FUS2	YMR232W		736925,	738959,	Cytoplasmic protein localized to the shmoo tip  required for the alignment of parental nuclei before nuclear fusion during mating
chrXIII	739184	739865	739184	739865	+	TRI1	YMR233W		739184,	739865,	Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus
chrXIII	740265	741312	740265	741312	+	RNH1	YMR234W		740265,	741312,	Ribonuclease H1  able to bind double-stranded RNAs and RNA-DNA hybrids  associates with RNAse polymerase I  the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
chrXIII	741511	742735	741511	742735	-	RNA1	YMR235C		741511,	742735,	GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
chrXIII	742970	743444	742970	743444	+	TAF9	YMR236W		742970,	743444,	Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
chrXIII	743748	745923	743748	745923	+	BCH1	YMR237W		743748,	745923,	Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane  may interact with ribosomes
chrXIII	746352	747729	746352	747729	+	DFG5	YMR238W		746352,	747729,	Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
chrXIII	748261	749677	748261	749677	-	RNT1	YMR239C		748261,	749677,	RNAase III  involved in rDNA transcription and rRNA processing  also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end  involved in polyadenylation-independent transcription termination
chrXIII	749929	751240	749929	751240	-	CUS1	YMR240C		749929,	751240,	Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
chrXIII	751960	752905	751960	752905	+	YHM2	YMR241W		751960,	752905,	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents  also associates with mt nucleoids and has a role in replication and segregation of the mt genome
chrXIII	753224	754220	753224	754220	-	RPL20A	YMR242C		753224,754219,	753742,754220,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein
chrXIII	754296	754386	754296	754386	+	YMR242W-A	YMR242W-A		754296,	754386,	Putative protein of unknown function
chrXIII	754837	756166	754837	756166	-	ZRC1	YMR243C		754837,	756166,	Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage  also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
chrXIII	757249	758317	757249	758317	+	YMR244W	YMR244W		757249,	758317,	Putative protein of unknown function
chrXIII	758516	758831	758516	758831	-	YMR244C-A	YMR244C-A		758516,	758831,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS  YMR244C-A is not an essential gene
chrXIII	758562	759183	758562	759183	+	YMR245W	YMR245W		758562,	759183,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	759806	761891	759806	761891	+	FAA4	YMR246W		759806,	761891,	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths  functions in long chain fatty acid import  important for survival during stationary phase  localized to lipid particles
chrXIII	763350	768039	763350	768039	-	RKR1	YMR247C		763350,	768039,	RING domain E3 ubiquitin ligase  involved in the ubiquitin-mediated degradation of non-stop proteins  functional connections to chromatin modification  nuclear protein that also co-localizes with ribosomes  homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
chrXIII	769282	769426	769282	769426	+	YMR247W-A	YMR247W-A		769282,	769426,	Putative protein of unknown function
chrXIII	770800	772558	770800	772558	+	GAD1	YMR250W		770800,	772558,	Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism  involved in response to oxidative stress
chrXIII	772914	774015	772914	774015	+	GTO3	YMR251W		772914,	774015,	Omega class glutathione transferase  putative cytosolic localization
chrXIII	774751	774931	774751	774931	+	HOR7	YMR251W-A		774751,	774931,	Protein of unknown function  overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p  transcription is induced under hyperosmotic stress and repressed by alpha factor
chrXIII	775314	775719	775314	775719	-	YMR252C	YMR252C		775314,	775719,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria  YMR252C is not an essential gene
chrXIII	775945	777190	775945	777190	-	YMR253C	YMR253C		775945,	777190,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern  YMR253C is not an essential gene
chrXIII	777614	777923	777614	777923	-	YMR254C	YMR254C		777614,	777923,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIII	778000	778567	778000	778567	+	GFD1	YMR255W		778000,	778567,	Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
chrXIII	778944	779127	778944	779127	-	COX7	YMR256C		778944,	779127,	Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
chrXIII	779628	782031	779628	782031	-	PET111	YMR257C		779628,	782031,	Mitochondrial translational activator specific for the COX2 mRNA  located in the mitochondrial inner membrane
chrXIII	782619	784281	782619	784281	-	YMR258C	YMR258C		782619,	784281,	GTPase inhibitor with similarity to F-box proteins  inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP  involved in regulating intracellular trafficking  physically interacts with Skp1p
chrXIII	784620	788883	784620	788883	-	YMR259C	YMR259C		784620,	788883,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YMR259C is not an essential gene
chrXIII	789377	789839	789377	789839	-	TIF11	YMR260C		789377,	789839,	Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon  C-terminus associates with Fun12p (eIF5B)  N terminus interacts with eIF2 and eIF3
chrXIII	790204	793369	790204	793369	-	TPS3	YMR261C		790204,	793369,	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose  expression is induced by stress conditions and repressed by the Ras-cAMP pathway
chrXIII	793725	794667	793725	794667	+	YMR262W	YMR262W		793725,	794667,	Protein of unknown function  interacts weakly with Knr4p  YMR262W is not an essential gene
chrXIII	794918	795524	794918	795524	+	SAP30	YMR263W		794918,	795524,	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci  involved in telomere maintenance
chrXIII	795804	796416	795804	796416	+	CUE1	YMR264W		795804,	796416,	Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation  contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination
chrXIII	796539	797925	796539	797925	-	YMR265C	YMR265C		796539,	797925,	Putative protein of unknown function
chrXIII	798517	801379	798517	801379	+	RSN1	YMR266W		798517,	801379,	Membrane protein of unknown function  overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane
chrXIII	801771	802704	801771	802704	+	PPA2	YMR267W		801771,	802704,	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
chrXIII	802887	804222	802887	804222	-	PRP24	YMR268C		802887,	804222,	Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
chrXIII	804455	805091	804455	805091	+	TMA23	YMR269W		804455,	805091,	Nucleolar protein implicated in ribosome biogenesis  deletion extends chronological lifespan
chrXIII	805325	806423	805325	806423	-	RRN9	YMR270C		805325,	806423,	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
chrXIII	806864	807548	806864	807548	-	URA10	YMR271C		806864,	807548,	Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate  major OPRTase encoded by URA5
chrXIII	809622	810777	809622	810777	-	SCS7	YMR272C		809622,	810777,	Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
chrXIII	810465	810579	810465	810579	+	YMR272W-A	YMR272W-A		810465,	810579,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene SCS7/YMR272C
chrXIII	811088	811196	811088	811196	+	YMR272W-B	YMR272W-B		811088,	811196,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXIII	811232	813980	811232	813980	-	ZDS1	YMR273C		811232,	813980,	Protein with a role in regulating Swe1p-dependent polarized growth  interacts with silencing proteins at the telomere  has a role in Bcy1p localization  implicated in mRNA nuclear export  involved in mitotic exit through Cdc14p regulation
chrXIII	814363	815311	814363	815311	-	RCE1	YMR274C		814363,	815311,	Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
chrXIII	815650	818581	815650	818581	-	BUL1	YMR275C		815650,	818581,	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases
chrXIII	818826	819948	818826	819948	+	DSK2	YMR276W		818826,	819948,	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome
chrXIII	820255	822454	820255	822454	+	FCP1	YMR277W		820255,	822454,	Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
chrXIII	822762	824631	822762	824631	+	PGM3	YMR278W		822762,	824631,	Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate  transcription induced in response to stress  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  non-essential
chrXIII	824728	826351	824728	826351	-	YMR279C	YMR279C		824728,	826351,	Putative boron transporter involved in boron efflux and resistance  overexpression mutant but not null mutant displays boron tolerance phenotype  identified as a heat-induced gene in a high-throughout screen  YMR279C is not an essential gene  paralog of the efflux pump ATR1
chrXIII	827027	831329	827027	831329	-	CAT8	YMR280C		827027,	831329,	Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
chrXIII	832338	833253	832338	833253	+	GPI12	YMR281W		832338,	833253,	ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate  functional homolog of human PIG-Lp
chrXIII	833355	835098	833355	835098	-	AEP2	YMR282C		833355,	835098,	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA  exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
chrXIII	835325	836867	835325	836867	-	RIT1	YMR283C		835325,	836867,	2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
chrXIII	838186	839995	838186	839995	+	YKU70	YMR284W		838186,	839995,	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect  relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
chrXIII	840143	841691	840143	841691	-	NGL2	YMR285C		840143,	841691,	Protein involved in 5.8S rRNA processing  Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E  similar to Ngl1p and Ngl3p
chrXIII	841941	842202	841941	842202	+	MRPL33	YMR286W		841941,	842202,	Mitochondrial ribosomal protein of the large subunit
chrXIII	842435	845345	842435	845345	-	DSS1	YMR287C		842435,	845345,	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p  the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
chrXIII	845570	848486	845570	848486	+	HSH155	YMR288W		845570,	848486,	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation  similarity to the mammalian U2 snRNP-associated splicing factor SAP155
chrXIII	848684	849809	848684	849809	+	ABZ2	YMR289W		848684,	849809,	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis  involved in folic acid biosynthesis
chrXIII	850073	851591	850073	851591	-	HAS1	YMR290C		850073,	851591,	ATP-dependent RNA helicase  localizes to both the nuclear periphery and nucleolus  highly enriched in nuclear pore complex fractions  constituent of 66S pre-ribosomal particles
chrXIII	851421	851769	851421	851769	+	YMR290W-A	YMR290W-A		851421,	851769,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
chrXIII	852629	854390	852629	854390	+	YMR291W	YMR291W		852629,	854390,	Putative kinase of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  null mutant is sensitive to expression of the top1-T722A allele  not an essential gene
chrXIII	854794	855293	854794	855293	+	GOT1	YMR292W		854794,854898,	854816,855293,	Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi  involved in secretory transport but not directly required for aspects of transport assayed in vitro  may influence membrane composition
chrXIII	855398	856793	855398	856793	-	HER2	YMR293C		855398,	856793,	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex  involved in the formation of Q-tRNAQ  required for remodeling of ER caused by Hmg2p overexpression  similar to bacterial GatA glutamyl-tRNA amidotransferase
chrXIII	856965	858087	856965	858087	+	JNM1	YMR294W		856965,	858087,	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p  required for proper nuclear migration and spindle partitioning during mitotic anaphase B
chrXIII	858208	858568	858208	858568	+	YMR294W-A	YMR294W-A		858208,	858568,	Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C  deletion causes sensitivity to unfolded protein response-inducing agents
chrXIII	858296	858890	858296	858890	-	YMR295C	YMR295C		858296,	858890,	Protein of unknown function that associates with ribosomes  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud  YMR295C is not an essential gene
chrXIII	859214	860891	859214	860891	-	LCB1	YMR296C		859214,	860891,	Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
chrXIII	861921	863520	861921	863520	+	PRC1	YMR297W		861921,	863520,	Vacuolar carboxypeptidase Y (proteinase C  CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole  member of the serine carboxypeptidase family
chrXIII	863818	864271	863818	864271	+	LIP1	YMR298W		863818,	864271,	Ceramide synthase subunit  single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
chrXIII	864411	865350	864411	865350	-	DYN3	YMR299C		864411,	865350,	Dynein light intermediate chain (LIC)  localizes with dynein, null mutant is defective in nuclear migration
chrXIII	865558	867091	865558	867091	-	ADE4	YMR300C		865558,	867091,	Phosphoribosylpyrophosphate amidotransferase (PRPPAT  amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
chrXIII	867554	869627	867554	869627	-	ATM1	YMR301C		867554,	869627,	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
chrXIII	870072	872625	870072	872625	-	YME2	YMR302C		870072,	872625,	Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number  mutants exhibit an increased rate of mitochondrial DNA escape  shows some sequence similarity to exonucleases
chrXIII	873290	874337	873290	874337	-	ADH2	YMR303C		873290,	874337,	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde  involved in the production of certain carboxylate esters  regulated by ADR1
chrXIII	874986	878679	874986	878679	+	UBP15	YMR304W		874986,	878679,	Ubiquitin-specific protease involved in protein deubiquitination  catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences  physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p
chrXIII	878779	879130	878779	879130	-	YMR304C-A	YMR304C-A		878779,	879130,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene SCW10
chrXIII	879062	880232	879062	880232	-	SCW10	YMR305C		879062,	880232,	Cell wall protein with similarity to glucanases  may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
chrXIII	881158	886516	881158	886516	+	FKS3	YMR306W		881158,	886516,	Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIII	886182	886572	886182	886572	-	YMR306C-A	YMR306C-A		886182,	886572,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	887002	888682	887002	888682	+	GAS1	YMR307W		887002,	888682,	Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing  localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor  also found at the nuclear periphery
chrXIII	887730	887925	887730	887925	-	YMR307C-A	YMR307C-A		887730,	887925,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene GAS1/YMR307W
chrXIII	888951	892221	888951	892221	-	PSE1	YMR308C		888951,	892221,	Karyopherin/importin that interacts with the nuclear pore complex  acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
chrXIII	892987	895426	892987	895426	-	NIP1	YMR309C		892987,	895426,	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
chrXIII	895715	896669	895715	896669	-	YMR310C	YMR310C		895715,	896669,	Putative protein of unknown function  predicted to be involved in ribosome biogenesis  green fluorescent protein (GFP)-fusion protein localizes to the nucleus  YMR310C is not an essential gene
chrXIII	896913	897603	896913	897603	-	GLC8	YMR311C		896913,	897603,	Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation  proposed to regulate Glc7p activity via conformational alteration  ortholog of the mammalian protein phosphatase inhibitor 2
chrXIII	898404	899226	898404	899226	+	ELP6	YMR312W		898404,	899226,	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA  required for Elongator structural integrity
chrXIII	899378	901307	899378	901307	-	TGL3	YMR313C		899378,	901307,	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity  responsible for all the triacylglycerol lipase activity of the lipid particle  required with Tgl4p for timely bud formation
chrXIII	901708	902413	901708	902413	+	PRE5	YMR314W		901708,	902413,	Alpha 6 subunit of the 20S proteasome
chrXIII	902799	903849	902799	903849	+	YMR315W	YMR315W		902799,	903849,	Protein with NADP(H) oxidoreductase activity  transcription is regulated by Stb5p in response to NADPH depletion induced by diamide  promoter contains a putative Stb5p binding site
chrXIII	904285	904393	904285	904393	+	YMR315W-A	YMR315W-A		904285,	904393,	Putative protein of unknown function
chrXIII	904824	905835	904824	905835	+	DIA1	YMR316W		904824,	905835,	Protein of unknown function, involved in invasive and pseudohyphal growth  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrXIII	905661	905973	905661	905973	-	YMR316C-A	YMR316C-A		905661,	905973,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene DIA1/YMR316W
chrXIII	907320	907629	907320	907629	-	YMR316C-B	YMR316C-B		907320,	907629,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIII	907363	910786	907363	910786	+	YMR317W	YMR317W		907363,	910786,	Putative protein of unknown function with some similarity to sialidase from Trypanosoma  YMR317W is not an essential gene
chrXIII	911060	912143	911060	912143	-	ADH6	YMR318C		911060,	912143,	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity  member of the cinnamyl family of alcohol dehydrogenases  may be involved in fusel alcohol synthesis or in aldehyde tolerance
chrXIII	912879	914538	912879	914538	-	FET4	YMR319C		912879,	914538,	Low-affinity Fe(II) transporter of the plasma membrane
chrXIII	916745	917051	916745	917051	+	YMR320W	YMR320W		916745,	917051,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIII	917578	917896	917578	917896	-	YMR321C	YMR321C		917578,	917896,	Putative protein of unknown function  proposed to be a palmitoylated membrane protein
chrXIII	918365	919079	918365	919079	-	SNO4	YMR322C		918365,	919079,	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p  DJ-1/ThiJ/PfpI superfamily member  predicted involvement in pyridoxine metabolism  induced by mild heat stress and copper deprivation
chrXIII	920087	921401	920087	921401	+	ERR3	YMR323W		920087,	921401,	Protein of unknown function, has similarity to enolases
chrXIII	922201	922444	922201	922444	-	YMR324C	YMR324C		922201,	922444,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  transcription is AZF1 dependent in glycerol-lactate medium and SLT2 dependent in response to the lipid hydroperoxides
chrXIII	922640	923015	922640	923015	+	PAU19	YMR325W		922640,	923015,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
chrXIII	923493	923802	923493	923802	-	YMR326C	YMR326C		923493,	923802,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the telomere on the right arm of chromosome 13
chrXIV	370	6098	370	6098	-	YRF1-6	YNL339C		370,6079,	5931,6098,	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1  potentially phosphorylated by Cdc28p
chrXIV	733	1216	733	1216	+	YNL339W-B	YNL339W-B		733,	1216,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXIV	1516	2092	1516	2092	+	YNL339W-A	YNL339W-A		1516,	2092,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXIV	6560	6719	6560	6719	+	YNL338W	YNL338W		6560,	6719,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
chrXIV	7164	7419	7164	7419	+	YNL337W	YNL337W		7164,	7419,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	8329	9475	8329	9475	+	COS1	YNL336W		8329,	9475,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrXIV	11451	12129	11451	12129	+	DDI3	YNL335W		11451,	12129,	Protein of unknown function  expression is induced over 100-fold by DNA damage  induction decreased in rad6 and rad18 mutants
chrXIV	12207	12876	12207	12876	-	SNO2	YNL334C		12207,	12876,	Protein of unknown function, nearly identical to Sno3p  expression is induced before the diauxic shift and also in the absence of thiamin
chrXIV	13266	14163	13266	14163	+	SNZ2	YNL333W		13266,	14163,	Member of a stationary phase-induced gene family  transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner  forms a coregulated gene pair with SNO2  interacts with Thi11p
chrXIV	14831	15854	14831	15854	+	THI12	YNL332W		14831,	15854,	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP)  member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
chrXIV	16117	17248	16117	17248	-	AAD14	YNL331C		16117,	17248,	Putative aryl-alcohol dehydrogenase  similar to P. chrysosporium aryl-alcohol dehydrogenase  mutational analysis has not yet revealed a physiological role
chrXIV	18000	19302	18000	19302	-	RPD3	YNL330C		18000,	19302,	Histone deacetylase  regulates transcription, silencing, and other processes by influencing chromatin remodeling  forms at least two different complexes which have distinct functions and members
chrXIV	19540	22633	19540	22633	-	PEX6	YNL329C		19540,	22633,	AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol
chrXIV	22833	23274	22833	23274	-	MDJ2	YNL328C		22833,	23274,	Constituent of the mitochondrial import motor associated with the presequence translocase  function overlaps with that of Pam18p  stimulates the ATPase activity of Ssc1p to drive mitochondrial import  contains a J domain
chrXIV	24047	27173	24047	27173	+	EGT2	YNL327W		24047,	27173,	Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
chrXIV	27336	28347	27336	28347	-	PFA3	YNL326C		27336,	28347,	Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion  contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain  autoacylates  required for vacuolar integrity under stress conditions
chrXIV	28738	31378	28738	31378	-	FIG4	YNL325C		28738,	31378,	Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase  required for efficient mating and response to osmotic shock  physically associates with and regulated by Vac14p  contains a SAC1-like domain
chrXIV	31049	31445	31049	31445	+	YNL324W	YNL324W		31049,	31445,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIV	31943	33188	31943	33188	+	LEM3	YNL323W		31943,	33188,	Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p  involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
chrXIV	33293	34235	33293	34235	-	KRE1	YNL322C		33293,	34235,	Cell wall glycoprotein involved in beta-glucan assembly  serves as a K1 killer toxin membrane receptor
chrXIV	34695	37422	34695	37422	+	VNX1	YNL321W		34695,	37422,	Calcium/H+ antiporter localized to the endoplasmic reticulum membrane  member of the calcium exchanger (CAX) family  potential Cdc28p substrate
chrXIV	37699	38554	37699	38554	+	YNL320W	YNL320W		37699,	38554,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	38641	39082	38641	39082	+	YNL319W	YNL319W		38641,	39082,	Dubious open reading frame unlikely to encode a protein  partially overlaps the verified gene HXT14
chrXIV	38706	40329	38706	40329	-	HXT14	YNL318C		38706,	40329,	Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	40618	42016	40618	42016	+	PFS2	YNL317W		40618,	42016,	Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex  plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
chrXIV	42070	43075	42070	43075	-	PHA2	YNL316C		42070,	43075,	Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
chrXIV	43323	44280	43323	44280	-	ATP11	YNL315C		43323,	44280,	Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
chrXIV	44446	45214	44446	45214	+	DAL82	YNL314W		44446,	45214,	Positive regulator of allophanate inducible genes  binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate  contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
chrXIV	45307	48022	45307	48022	-	EMW1	YNL313C		45307,	48022,	Essential conserved protein with a role in maintaining cell wall integrity  contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region  conditional mutant is suppressed by overexpression of GFA1
chrXIV	48286	49216	48286	49216	+	RFA2	YNL312W		48286,48401,	48293,49216,	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
chrXIV	49396	51688	49396	51688	-	SKP2	YNL311C		49396,	51688,	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex  involved in regulating protein levels of sulfur metabolism enzymes  may interact with ribosomes, based on co-purification experiments
chrXIV	51906	52431	51906	52431	-	ZIM17	YNL310C		51906,	52431,	Heat shock protein with a zinc finger motif  essential for protein import into mitochondria  may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
chrXIV	52661	53924	52661	53924	+	STB1	YNL309W		52661,	53924,	Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro  unphosphorylated form binds Swi6p and binding is required for Stb1p function  expression is cell-cycle regulated
chrXIV	54121	55897	54121	55897	-	KRI1	YNL308C		54121,	55897,	Essential nucleolar protein required for 40S ribosome biogenesis  physically and functionally interacts with Krr1p
chrXIV	56445	57573	56445	57573	-	MCK1	YNL307C		56445,	57573,	Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis  related to mammalian glycogen synthase kinases of the GSK-3 family
chrXIV	58154	58808	58154	58808	+	MRPS18	YNL306W		58154,	58808,	Mitochondrial ribosomal protein of the small subunit  essential for viability, unlike most other mitoribosomal proteins
chrXIV	58897	59791	58897	59791	-	YNL305C	YNL305C		58897,	59791,	Protein involved in apoptosis  variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family  reported to promote apoptosis under some conditions and to inhibit it in others  localizes to ER and vacuole  may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling  translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
chrXIV	60296	61550	60296	61550	+	YPT11	YNL304W		60296,	61550,	Rab family GTPase that interacts with the C-terminal tail domain of Myo2p  mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
chrXIV	61509	61857	61509	61857	+	YNL303W	YNL303W		61509,	61857,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	61957	62943	61957	62943	-	RPS19B	YNL302C		61957,62923,	62372,62943,	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles  mutations in human RPS19 are associated with Diamond Blackfan anemia  nearly identical to Rps19Ap
chrXIV	63569	64562	63569	64562	-	RPL18B	YNL301C		63569,64450,	64018,64562,	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
chrXIV	65743	66052	65743	66052	+	TOS6	YNL300W		65743,	66052,	Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase  depletion increases resistance to lactic acid
chrXIV	66516	68445	66516	68445	+	TRF5	YNL299W		66516,	68445,	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex  catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors  overlapping but non-redundant functions with Pap2p
chrXIV	68914	71443	68914	71443	+	CLA4	YNL298W		68914,	71443,	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p  involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation  phosphorylates Cdc3p and Cdc10p
chrXIV	71672	76583	71672	76583	-	MON2	YNL297C		71672,	76583,	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome  member of the Sec7p family of proteins
chrXIV	76272	76587	76272	76587	+	YNL296W	YNL296W		76272,	76587,	Dubious open reading frame unlikely to encode a functional protein  deletion adversely affects sporulation  deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog
chrXIV	76945	78520	76945	78520	+	YNL295W	YNL295W		76945,	78520,	Putative protein of unknown function
chrXIV	78658	80260	78658	80260	-	RIM21	YNL294C		78658,	80260,	Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response  has similarity to A. nidulans PalH
chrXIV	80639	82541	80639	82541	+	MSB3	YNL293W		80639,	82541,	GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization  similar to Msb4p  both Msb3p and Msb4p localize to sites of polarized growth
chrXIV	82805	84017	82805	84017	+	PUS4	YNL292W		82805,	84017,	Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs  PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
chrXIV	84168	85815	84168	85815	-	MID1	YNL291C		84168,	85815,	N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone  interacts with Cch1p  forms an oligomer
chrXIV	86217	87240	86217	87240	+	RFC3	YNL290W		86217,	87240,	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
chrXIV	87896	88736	87896	88736	+	PCL1	YNL289W		87896,	88736,	Cyclin, interacts with cyclin-dependent kinase Pho85p  member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle  localizes to sites of polarized cell growth
chrXIV	90302	91424	90302	91424	+	CAF40	YNL288W		90302,	91424,	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation  binds Cdc39p
chrXIV	91993	94801	91993	94801	+	SEC21	YNL287W		91993,	94801,	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat  involved in ER to Golgi transport of selective cargo
chrXIV	95222	96080	95222	96080	+	CUS2	YNL286W		95222,	96080,	Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding  contains two RNA recognition motifs (RRMs)
chrXIV	96172	96544	96172	96544	+	YNL285W	YNL285W		96172,	96544,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIV	96963	102232	96963	102232	-	YNL284C-B	YNL284C-B		96963,100927,	100926,102232,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXIV	100909	102232	100909	102232	-	YNL284C-A	YNL284C-A		100909,	102232,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXIV	103133	104102	103133	104102	-	MRPL10	YNL284C		103133,	104102,	Mitochondrial ribosomal protein of the large subunit  appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
chrXIV	105183	106695	105183	106695	-	WSC2	YNL283C		105183,	106695,	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock  secretory pathway Wsc2p is required for the arrest of secretion response
chrXIV	107686	108274	107686	108274	+	POP3	YNL282W		107686,	108274,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
chrXIV	108466	108928	108466	108928	+	HCH1	YNL281W		108466,	108928,	Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity  originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation  GFP-fusion protein localizes to the cytoplasm and nucleus
chrXIV	109094	110411	109094	110411	-	ERG24	YNL280C		109094,	110411,	C-14 sterol reductase, acts in ergosterol biosynthesis  mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
chrXIV	110916	112902	110916	112902	+	PRM1	YNL279W		110916,	112902,	Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating  predicted to have 5 transmembrane segments and a coiled coil domain  localizes to the shmoo tip  regulated by Ste12p
chrXIV	113270	116453	113270	116453	+	CAF120	YNL278W		113270,	116453,	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
chrXIV	116678	116867	116678	116867	+	YNL277W-A	YNL277W-A		116678,	116867,	Putative protein of unknown function
chrXIV	117348	118809	117348	118809	+	MET2	YNL277W		117348,	118809,	L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
chrXIV	118430	118826	118430	118826	-	YNL276C	YNL276C		118430,	118826,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene MET2/YNL277W
chrXIV	119267	120998	119267	120998	+	BOR1	YNL275W		119267,	120998,	Boron efflux transporter of the plasma membrane  binds HCO3-, I-, Br-, NO3- and Cl-  has similarity to the characterized boron efflux transporter A. thaliana BOR1
chrXIV	121117	122170	121117	122170	-	GOR1	YNL274C		121117,	122170,	Glyoxylate reductase  null mutation results in increased biomass after diauxic shift  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	122882	126599	122882	126599	+	TOF1	YNL273W		122882,	126599,	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA  interacts with the MCM helicase
chrXIV	126804	129084	126804	129084	-	SEC2	YNL272C		126804,	129084,	Guanyl-nucleotide exchange factor for the small G-protein Sec4p  essential for post-Golgi vesicle transport and for autophagy  associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
chrXIV	129521	135383	129521	135383	-	BNI1	YNL271C		129521,	135383,	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
chrXIV	135939	137661	135939	137661	-	ALP1	YNL270C		135939,	137661,	Arginine transporter  expression is normally very low and it is unclear what conditions would induce significant expression
chrXIV	137698	138094	137698	138094	+	BSC4	YNL269W		137698,	138094,	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression  readthrough is increased upon depletion of Sup35p
chrXIV	138549	140385	138549	140385	+	LYP1	YNL268W		138549,	140385,	Lysine permease  one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
chrXIV	140877	144078	140877	144078	+	PIK1	YNL267W		140877,	144078,	Phosphatidylinositol 4-kinase  catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate  may control cytokinesis through the actin cytoskeleton
chrXIV	144244	144664	144244	144664	+	YNL266W	YNL266W		144244,	144664,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF IST1/YNL265C
chrXIV	144279	145281	144279	145281	-	IST1	YNL265C		144279,145254,	145149,145281,	Protein with a positive role in the multivesicular body sorting pathway  functions and forms a complex with Did2p  recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III  also interacts with Vps4p
chrXIV	145562	146615	145562	146615	-	PDR17	YNL264C		145562,	146615,	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
chrXIV	146895	147840	146895	147840	-	YIF1	YNL263C		146895,	147840,	Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi  interacts with Yip1p and Yos1p  localizes to the Golgi, the ER, and COPII vesicles  homolog of human YIPF3
chrXIV	148211	154880	148211	154880	+	POL2	YNL262W		148211,	154880,	Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity  also involved in DNA synthesis during DNA repair  interacts extensively with Mrc1p
chrXIV	155099	156539	155099	156539	+	ORC5	YNL261W		155099,	156539,	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
chrXIV	156858	157455	156858	157455	-	YNL260C	YNL260C		156858,	157455,	Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers  essential gene with defects in anaerobic and filamentous growth  localizes to the nucleus and cytoplasm
chrXIV	157643	157865	157643	157865	-	ATX1	YNL259C		157643,	157865,	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
chrXIV	158108	160373	158108	160373	-	DSL1	YNL258C		158108,	160373,	Peripheral membrane protein needed for Golgi-to-ER retrograde traffic  forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p  component of the ER target site that interacts with coatomer  interacts with Cin5p
chrXIV	160630	164320	160630	164320	-	SIP3	YNL257C		160630,	164320,	Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif  potential Cdc28p substrate
chrXIV	164622	167097	164622	167097	+	FOL1	YNL256W		164622,	167097,	Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
chrXIV	167328	167790	167328	167790	-	GIS2	YNL255C		167328,	167790,	Translational activator for mRNAs with internal ribosome entry sites  associates with polysomes and binds to a specific subset of mRNAs  ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
chrXIV	168042	169248	168042	169248	-	RTC4	YNL254C		168042,	169248,	Protein of unknown function  null mutation suppresses cdc13-1 temperature sensitivity  (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrXIV	170017	171286	170017	171286	+	TEX1	YNL253W		170017,	171286,	Protein involved in mRNA export, component of the transcription export (TREX) complex
chrXIV	171440	172286	171440	172286	-	MRPL17	YNL252C		171440,	172286,	Mitochondrial ribosomal protein of the large subunit
chrXIV	172587	174315	172587	174315	-	NRD1	YNL251C		172587,	174315,	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p)  complex mediates termination of snoRNAs and cryptic unstable transcripts (CUTs)  interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5  H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites  required for 3' end maturation of nonpolyadenylated RNAs
chrXIV	175409	179348	175409	179348	+	RAD50	YNL250W		175409,	179348,	Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
chrXIV	179393	181022	179393	181022	-	MPA43	YNL249C		179393,	181022,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	181360	182608	181360	182608	-	RPA49	YNL248C		181360,	182608,	RNA polymerase I subunit A49
chrXIV	182874	185178	182874	185178	+	YNL247W	YNL247W		182874,	185178,	Cysteinyl-tRNA synthetase  may interact with ribosomes, based on co-purification experiments
chrXIV	185459	186349	185459	186349	+	VPS75	YNL246W		185459,185586,	185491,186349,	NAP family histone chaperone  binds to histones and Rtt109p, stimulating histone acetyltransferase activity  possesses nucleosome assembly activity in vitro  proposed role in vacuolar protein sorting and in double-strand break repair
chrXIV	186345	186885	186345	186885	-	CWC25	YNL245C		186345,	186885,	Splicing factor required for the first step of pre-mRNA splicing  binding to the spliceosome requires Prp2p and Yju2p  heat-stable protein  has similarity to S. pombe Cwf25p
chrXIV	187169	187496	187169	187496	-	SUI1	YNL244C		187169,	187496,	Translation initiation factor eIF1  component of a complex involved in recognition of the initiator codon  modulates translation accuracy at the initiation phase
chrXIV	188050	190957	188050	190957	+	SLA2	YNL243W		188050,	190957,	Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization  adaptor protein that links actin to clathrin and endocytosis  present in the actin cortical patch of the emerging bud tip  dimer in vivo
chrXIV	191323	196102	191323	196102	+	ATG2	YNL242W		191323,	196102,	Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway  involved in Atg9p cycling between the phagophore assembly site and mitochondria
chrXIV	196425	197943	196425	197943	-	ZWF1	YNL241C		196425,	197943,	Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway  involved in adapting to oxidatve stress  homolog of the human G6PD which is deficient in patients with hemolytic anemia
chrXIV	198501	199977	198501	199977	-	NAR1	YNL240C		198501,	199977,	Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress  homologous to human Narf
chrXIV	200568	201933	200568	201933	+	LAP3	YNL239W		200568,	201933,	Cysteine aminopeptidase with homocysteine-thiolactonase activity  protects cells against homocysteine toxicity  has bleomycin hydrolase activity in vitro  transcription is regulated by galactose via Gal4p  orthologous to human BLMH
chrXIV	202427	204872	202427	204872	+	KEX2	YNL238W		202427,	204872,	Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
chrXIV	205187	206567	205187	206567	+	YTP1	YNL237W		205187,	206567,	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
chrXIV	206929	209854	206929	209854	+	SIN4	YNL236W		206929,	209854,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  contributes to both postive and negative transcriptional regulation  dispensible for basal transcription
chrXIV	209547	209979	209547	209979	-	YNL235C	YNL235C		209547,	209979,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
chrXIV	210232	211513	210232	211513	+	YNL234W	YNL234W		210232,	211513,	Protein of unknown function with similarity to globins  has a functional heme-binding domain  mutant has aneuploidy tolerance  transcription induced by stress conditions  may be involved in glucose signaling or metabolism  regulated by Rgt1
chrXIV	211921	214600	211921	214600	+	BNI4	YNL233W		211921,	214600,	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
chrXIV	214922	215801	214922	215801	+	CSL4	YNL232W		214922,	215801,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  predicted to contain an S1 RNA binding domain  has similarity to human hCsl4p (EXOSC1)
chrXIV	215986	217042	215986	217042	-	PDR16	YNL231C		215986,	217042,	Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
chrXIV	217522	218662	217522	218662	-	ELA1	YNL230C		217522,	218662,	Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21  subunit of the Elongin-Cullin-Socs (ECS) ligase complex
chrXIV	219136	220201	219136	220201	-	URE2	YNL229C		219136,	220201,	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source  has glutathione peroxidase activity and can mutate to acquire GST activity  altered form creates [URE3] prion
chrXIV	220644	221421	220644	221421	+	YNL228W	YNL228W		220644,	221421,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  almost completely overlaps ORF YNL227C/JJJ1
chrXIV	220658	222431	220658	222431	-	JJJ1	YNL227C		220658,	222431,	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis  associated with the cytosolic large ribosomal subunit  contains a J-domain  mutation causes defects in fluid-phase endocytosis
chrXIV	222238	222649	222238	222649	+	YNL226W	YNL226W		222238,	222649,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene JJJ1/YNL227C
chrXIV	222723	224469	222723	224469	-	CNM67	YNL225C		222723,	224469,	Component of the spindle pole body outer plaque  required for spindle orientation and mitotic nuclear migration
chrXIV	224795	227099	224795	227099	-	SQS1	YNL224C		224795,	227099,	Stimulates the ATPase and helicase activities of Prp43p  acts with Prp43p to stimulate 18s rRNA maturation by Nob1p  overexpression antagonizes the suppression of splicing defects by spp382 mutants  component of pre-ribosomal particles
chrXIV	227369	228854	227369	228854	+	ATG4	YNL223W		227369,	228854,	Conserved cysteine protease required for autophagy  cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation
chrXIV	229093	229714	229093	229714	+	SSU72	YNL222W		229093,	229714,	Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p  exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain  affects start site selection in vivo
chrXIV	231067	233695	231067	233695	-	POP1	YNL221C		231067,	233695,	Subunit of both RNase MRP and nuclear RNase P  RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs  binds to the RPR1 RNA subunit in RNase P
chrXIV	234412	235714	234412	235714	+	ADE12	YNL220W		234412,	235714,	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis  exhibits binding to single-stranded autonomously replicating (ARS) core sequence
chrXIV	235995	237663	235995	237663	-	ALG9	YNL219C		235995,	237663,	Mannosyltransferase, involved in N-linked glycosylation  catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides  mutation of the human ortholog causes type 1 congenital disorders of glycosylation
chrXIV	238237	240001	238237	240001	+	MGS1	YNL218W		238237,	240001,	Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome  interacts functionally with DNA polymerase delta  homolog of human Werner helicase interacting protein (WHIP)
chrXIV	240330	241311	240330	241311	+	YNL217W	YNL217W		240330,	241311,	Putative protein of unknown function  weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases  (GFP)-fusion protein localizes to the vacuole  null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
chrXIV	241688	244172	241688	244172	+	RAP1	YNL216W		241688,	244172,	DNA-binding protein involved in either activation or repression of transcription, depending on binding site context  also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
chrXIV	244467	245430	244467	245430	+	IES2	YNL215W		244467,	245430,	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions  essential for growth under anaerobic conditions
chrXIV	245616	246216	245616	246216	+	PEX17	YNL214W		245616,	246216,	Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins  required for peroxisome biogenesis
chrXIV	246459	247104	246459	247104	-	RRG9	YNL213C		246459,	247104,	Protein of unknown function  null mutant lacks mitochondrial DNA and cannot grow on glycerol  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	247460	249809	247460	249809	+	VID27	YNL212W		247460,	249809,	Cytoplasmic protein of unknown function  possibly involved in vacuolar protein degradation  not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase)  null mutants exhibit normal growth
chrXIV	250054	250315	250054	250315	-	YNL211C	YNL211C		250054,	250315,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria  YNL211C is not an essential gene
chrXIV	250930	251743	250930	251743	+	MER1	YNL210W		250930,	251743,	Protein with RNA-binding motifs required for meiosis-specific mRNA splicing  required for chromosome pairing and meiotic recombination  Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22
chrXIV	252058	253900	252058	253900	+	SSB2	YNL209W		252058,	253900,	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p  may be involved in the folding of newly-synthesized polypeptide chains  member of the HSP70 family  homolog of SSB1
chrXIV	254417	255017	254417	255017	+	YNL208W	YNL208W		254417,	255017,	Protein of unknown function  may interact with ribosomes, based on co-purification experiments  authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies  potential orthologs found in other fungi
chrXIV	255352	256630	255352	256630	+	RIO2	YNL207W		255352,	256630,	Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA  has similarity to Rio1p
chrXIV	256787	258155	256787	258155	-	RTT106	YNL206C		256787,	258155,	Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions  affects transcriptional elongation  has a role in regulation of Ty1 transposition
chrXIV	258154	258577	258154	258577	-	YNL205C	YNL205C		258154,	258577,	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIV	258374	259277	258374	259277	-	SPS18	YNL204C		258374,	259277,	Protein of unknown function, contains a putative zinc-binding domain  expressed during sporulation
chrXIV	259438	260050	259438	260050	-	YNL203C	YNL203C		259438,	260050,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIV	259577	260456	259577	260456	+	SPS19	YNL202W		259577,	260456,	Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation  homodimeric enzyme required for growth and sporulation on petroselineate medium  expression induced during late sporulation and in the presence of oleate
chrXIV	260626	263203	260626	263203	-	PSY2	YNL201C		260626,	263203,	Subunit of protein phosphatase PP4 complex  active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases  regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair  Pph3p and Psy2p localize to foci on meiotic chromosomes  putative homolog of mammalian R3
chrXIV	263712	264453	263712	264453	-	YNL200C	YNL200C		263712,	264453,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	264925	266530	264925	266530	-	GCR2	YNL199C		264925,	266530,	Transcriptional activator of genes involved in glycolysis  interacts and functions with the DNA-binding protein Gcr1p
chrXIV	266513	266816	266513	266816	-	YNL198C	YNL198C		266513,	266816,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	267607	269593	267607	269593	-	WHI3	YNL197C		267607,	269593,	RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci  cytoplasmic retention factor for Cdc28p and associated cyclins  regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
chrXIV	270274	271171	270274	271171	-	SLZ1	YNL196C		270274,	271171,	Sporulation-specific protein with a leucine zipper motif
chrXIV	271522	272308	271522	272308	-	YNL195C	YNL195C		271522,	272308,	Putative protein of unknown function  shares a promoter with YNL194C  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	272709	273615	272709	273615	-	YNL194C	YNL194C		272709,	273615,	Integral membrane protein required for sporulation and plasma membrane sphingolipid content  has sequence similarity to SUR7 and FMP45  GFP-fusion protein is induced in response to the DNA-damaging agent MMS
chrXIV	274367	276044	274367	276044	+	YNL193W	YNL193W		274367,	276044,	Putative protein of unknown function  exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
chrXIV	276501	279897	276501	279897	+	CHS1	YNL192W		276501,	279897,	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin  required for repairing the chitin septum during cytokinesis  transcription activated by mating factor
chrXIV	280431	281505	280431	281505	+	DUG3	YNL191W		280431,	281505,	Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
chrXIV	282394	283009	282394	283009	+	YNL190W	YNL190W		282394,	283009,	Cell wall protein of unknown function  proposed role as a hydrophilin induced by osmotic stress  contains a putative GPI-attachment site
chrXIV	284259	285888	284259	285888	+	SRP1	YNL189W		284259,	285888,	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import  may also play a role in regulation of protein degradation
chrXIV	286307	287609	286307	287609	+	KAR1	YNL188W		286307,	287609,	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
chrXIV	287993	289067	287993	289067	+	SWT21	YNL187W		287993,	289067,	Protein involved in mRNA splicing  contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p  interacts genetically with Prp40p and Tgs1p  contains WD40 repeats
chrXIV	289497	291876	289497	291876	+	UBP10	YNL186W		289497,	291876,	Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties  may regulate silencing by acting on Sir4p  involved in posttranscriptionally regulating Gap1p and possibly other transporters  primarily located in the nucleus
chrXIV	292192	292669	292192	292669	-	MRPL19	YNL185C		292192,	292669,	Mitochondrial ribosomal protein of the large subunit
chrXIV	292556	292883	292556	292883	-	YNL184C	YNL184C		292556,	292883,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	293136	295509	293136	295509	-	NPR1	YNL183C		293136,	295509,	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation  phosphorylates Aly2p
chrXIV	295959	297627	295959	297627	-	IPI3	YNL182C		295959,	297627,	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA  highly conserved and contains WD40 motifs  Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
chrXIV	298334	299558	298334	299558	+	YNL181W	YNL181W		298334,	299558,	Putative oxidoreductase  required for cell viability
chrXIV	299653	300649	299653	300649	-	RHO5	YNL180C		299653,	300649,	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
chrXIV	300665	301103	300665	301103	-	YNL179C	YNL179C		300665,	301103,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  deletion in cyr1 mutant results in loss of stress resistance
chrXIV	302679	303402	302679	303402	+	RPS3	YNL178W		302679,	303402,	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity  essential for viability  has similarity to E. coli S3 and rat S3 ribosomal proteins
chrXIV	303685	304615	303685	304615	-	MRPL22	YNL177C		303685,	304615,	Mitochondrial ribosomal protein of the large subunit
chrXIV	305069	306980	305069	306980	-	YNL176C	YNL176C		305069,	306980,	Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p  null mutant is sensitive to expression of the top1-T722A allele
chrXIV	307400	308612	307400	308612	-	NOP13	YNL175C		307400,	308612,	Nucleolar protein found in preribosomal complexes  contains an RNA recognition motif (RRM)
chrXIV	308073	308646	308073	308646	+	YNL174W	YNL174W		308073,	308646,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene NOP13/YNL175C
chrXIV	308956	310057	308956	310057	-	MDG1	YNL173C		308956,	310057,	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway  overproduction suppresses bem1 mutations
chrXIV	310635	315882	310635	315882	+	APC1	YNL172W		310635,	315882,	Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition  component of the platform domain of the APC/C, based on structural analysis
chrXIV	315628	315997	315628	315997	-	YNL171C	YNL171C		315628,	315997,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIV	315977	316373	315977	316373	+	YNL170W	YNL170W		315977,	316373,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIV	316168	317671	316168	317671	-	PSD1	YNL169C		316168,	317671,	Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
chrXIV	318029	318809	318029	318809	-	FMP41	YNL168C		318029,	318809,	Putative protein of unknown function  GFP-fusion protein is induced in response to the DNA-damaging agent MMS  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	319415	321359	319415	321359	-	SKO1	YNL167C		319415,	321359,	Basic leucine zipper transcription factor of the ATF/CREB family  forms a complex with Tup1p and Cyc8p to both activate and repress transcription  cytosolic and nuclear protein involved in osmotic and oxidative stress responses
chrXIV	322218	323565	322218	323565	-	BNI5	YNL166C		322218,	323565,	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
chrXIV	323831	325052	323831	325052	+	YNL165W	YNL165W		323831,	325052,	Putative protein of unknown function  YNL165W is not an essential gene
chrXIV	325264	326320	325264	326320	-	IBD2	YNL164C		325264,	326320,	Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p
chrXIV	326740	330073	326740	330073	-	RIA1	YNL163C		326740,	330073,	Cytoplasmic GTPase involved in biogenesis of the 60S ribosome  has similarity to translation elongation factor 2 (Eft1p and Eft2p)
chrXIV	330328	330547	330328	330547	+	YNL162W-A	YNL162W-A		330328,	330547,	Putative protein of unknown function  identified by homology
chrXIV	331321	332154	331321	332154	+	RPL42A	YNL162W		331321,331837,	331325,332154,	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
chrXIV	332596	334867	332596	334867	+	CBK1	YNL161W		332596,	334867,	Serine/threonine protein kinase that regulates cell morphogenesis pathways, including cell wall biosynthesis, mating projection morphology, bipolar bud site selection  regulates SRL1 mRNA localization via phosphorylation of substrate Ssd1p
chrXIV	336544	337609	336544	337609	+	YGP1	YNL160W		336544,	337609,	Cell wall-related secretory glycoprotein  induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase  may be involved in adaptation prior to stationary phase entry  has similarity to Sps100p
chrXIV	338477	339347	338477	339347	-	ASI2	YNL159C		338477,	339347,	Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
chrXIV	339611	340208	339611	340208	+	PGA1	YNL158W		339611,	340208,	Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p  required for maturation of Gas1p and Pho8p  has synthetic genetic interations with secretory pathway genes
chrXIV	340351	340858	340351	340858	+	IGO1	YNL157W		340351,	340858,	Protein required for initiation of G0 program  prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway  phosphorylated by Rim15p  GFP protein localizes to the cytoplasm and nucleus  similar to Igo2p
chrXIV	341068	341968	341068	341968	-	NSG2	YNL156C		341068,	341968,	Protein involved in regulation of sterol biosynthesis  specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis  homolog of mammalian INSIG proteins
chrXIV	342515	343340	342515	343340	+	YNL155W	YNL155W		342515,	343340,	Putative protein of unknown function  contains a DHHC domain and an AN1-type zinc finger  predicted to have thiol-disulfide oxidoreductase active site  transcriptionally regulated by Rpn4p along with proteasome subunit genes  putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic
chrXIV	343635	345276	343635	345276	-	YCK2	YNL154C		343635,	345276,	Palmitoylated plasma membrane-bound casein kinase I isoform  shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking  provides an essential function overlapping with that of Yck1p
chrXIV	345668	346058	345668	346058	-	GIM3	YNL153C		345668,	346058,	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
chrXIV	346312	347542	346312	347542	+	INN1	YNL152W		346312,	347542,	Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis  C2 domain, a membrane targeting module, is required for function
chrXIV	347765	348521	347765	348521	-	RPC31	YNL151C		347765,	348521,	RNA polymerase III subunit C31
chrXIV	349250	349658	349250	349658	+	YNL150W	YNL150W		349250,	349658,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
chrXIV	349366	349756	349366	349756	-	PGA2	YNL149C		349366,	349756,	Essential protein required for maturation of Gas1p and Pho8p  involved in protein trafficking  GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network  null mutants have a cell separation defect
chrXIV	349906	350671	349906	350671	-	ALF1	YNL148C		349906,	350671,	Alpha-tubulin folding protein, similar to mammalian cofactor B  Alf1p-GFP localizes to cytoplasmic microtubules  required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
chrXIV	350939	351383	350939	351383	+	LSM7	YNL147W		350939,351053,	350957,351383,	Lsm (Like Sm) protein  part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay  nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
chrXIV	351385	351580	351385	351580	-	YNL146C-A	YNL146C-A		351385,	351580,	Putative protein of unknown function
chrXIV	351714	352017	351714	352017	+	YNL146W	YNL146W		351714,	352017,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  YNL146W is not an essential gene
chrXIV	352413	352530	352413	352530	+	MFA2	YNL145W		352413,	352530,	Mating pheromone a-factor, made by a cells  interacts with alpha cells to induce cell cycle arrest and other responses leading to mating  biogenesis involves C-terminal modification, N-terminal proteolysis, and export  also encoded by MFA1
chrXIV	352819	355042	352819	355042	-	YNL144C	YNL144C		352819,	355042,	Putative protein of unknown function  non-tagged protein is detected in highly purified mitochondria in high-throughput studies  contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study
chrXIV	353060	353144	353060	353144	+	YNL144W-A	YNL144W-A		353060,	353144,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized gene YNL144C
chrXIV	356793	357186	356793	357186	-	YNL143C	YNL143C		356793,	357186,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	357452	358952	357452	358952	+	MEP2	YNL142W		357452,	358952,	Ammonium permease involved in regulation of pseudohyphal growth  belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+)  expression is under the nitrogen catabolite repression regulation
chrXIV	359595	360639	359595	360639	+	AAH1	YNL141W		359595,	360639,	Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine  involved in purine salvage  transcriptionally regulated by nutrient levels and growth phase  Aah1p degraded upon entry into quiescence via SCF and the proteasome
chrXIV	360916	361486	360916	361486	-	YNL140C	YNL140C		360916,	361486,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene THO2/YNL139C
chrXIV	360923	365717	360923	365717	-	THO2	YNL139C		360923,	365717,	Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination  required for LacZ RNA expression from certain plasmids
chrXIV	366032	366412	366032	366412	+	YSF3	YNL138W-A		366032,366157,	366035,366412,	Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b
chrXIV	366740	368321	366740	368321	+	SRV2	YNL138W		366740,	368321,	CAP (cyclase-associated protein) subunit of adenylyl cyclase complex  N-terminus binds adenylyl cyclase and facilitates activation by RAS  C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
chrXIV	368594	370055	368594	370055	-	NAM9	YNL137C		368594,	370055,	Mitochondrial ribosomal component of the small subunit
chrXIV	370367	371645	370367	371645	+	EAF7	YNL136W		370367,	371645,	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
chrXIV	371881	372226	371881	372226	-	FPR1	YNL135C		371881,	372226,	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin  also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
chrXIV	372450	373581	372450	373581	-	YNL134C	YNL134C		372450,	373581,	Putative protein of unknown function with similarity to dehydrogenases from other model organisms  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
chrXIV	374170	374692	374170	374692	-	FYV6	YNL133C		374170,	374692,	Protein of unknown function, required for survival upon exposure to K1 killer toxin  proposed to regulate double-strand break repair via non-homologous end-joining
chrXIV	375320	378491	375320	378491	+	KRE33	YNL132W		375320,	378491,	Essential protein, required for biogenesis of the small ribosomal subunit  heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
chrXIV	378766	379225	378766	379225	+	TOM22	YNL131W		378766,	379225,	Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins  acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
chrXIV	379557	380831	379557	380831	-	CPT1	YNL130C		379557,380781,	380689,380831,	Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
chrXIV	381244	381391	381244	381391	-	DGR1	YNL130C-A		381244,	381391,	Protein of unknown function  dgr1 null mutant is resistant to 2-deoxy-D-glucose
chrXIV	381479	382202	381479	382202	+	NRK1	YNL129W		381479,	382202,	Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
chrXIV	382358	383663	382358	383663	+	TEP1	YNL128W		382358,	383663,	Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway  plays a role in normal sporulation
chrXIV	383986	386848	383986	386848	+	FAR11	YNL127W		383986,	386848,	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway  interacts with Far3p, Far7p, Far8p, Far9p, and Far10p  has similarity to the N- and C-termini of N. crassa HAM-2
chrXIV	387226	389767	387226	389767	+	SPC98	YNL126W		387226,	389767,	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex  interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
chrXIV	390145	392167	390145	392167	-	ESBP6	YNL125C		390145,	392167,	Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
chrXIV	392891	394370	392891	394370	+	NAF1	YNL124W		392891,	394370,	RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p  similar to Gar1p
chrXIV	394684	397678	394684	397678	+	NMA111	YNL123W		394684,	397678,	Serine protease and general molecular chaperone  involved in response to heat stress and promotion of apoptosis  may contribute to lipid homeostasis  sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
chrXIV	398022	398370	398022	398370	-	YNL122C	YNL122C		398022,	398370,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria  YNL122C is not an essential gene
chrXIV	398683	400537	398683	400537	-	TOM70	YNL121C		398683,	400537,	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins  acts as a receptor for incoming precursor proteins
chrXIV	401032	401518	401032	401518	-	YNL120C	YNL120C		401032,	401518,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
chrXIV	401039	402521	401039	402521	+	NCS2	YNL119W		401039,	402521,	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs  has a role in urmylation and in invasive and pseudohyphal growth  inhibits replication of Brome mosaic virus in S. cerevisiae
chrXIV	402651	405564	402651	405564	-	DCP2	YNL118C		402651,	405564,	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation  member of the Nudix hydrolase family
chrXIV	406357	408022	406357	408022	+	MLS1	YNL117W		406357,	408022,	Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources  expression is subject to carbon catabolite repression  localizes in peroxisomes during growth in oleic acid medium
chrXIV	408340	409909	408340	409909	+	DMA2	YNL116W		408340,	409909,	Protein involved in ubiquitination  plays a role in regulating spindle position and orientation  functionally redundant with Dma1p  orthologous to human RNF8 protein, also has sequence similarity to human Chfr
chrXIV	410118	412053	410118	412053	-	YNL115C	YNL115C		410118,	412053,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria  YNL115C is not an essential gene
chrXIV	412683	413055	412683	413055	-	YNL114C	YNL114C		412683,	413055,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
chrXIV	412770	413199	412770	413199	+	RPC19	YNL113W		412770,	413199,	RNA polymerase subunit AC19, common to RNA polymerases I and III
chrXIV	413638	416281	413638	416281	+	DBP2	YNL112W		413638,415913,	414911,416281,	Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
chrXIV	416939	417302	416939	417302	-	CYB5	YNL111C		416939,	417302,	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways  acts as an electron donor to support sterol C5-6 desaturation
chrXIV	417825	418488	417825	418488	-	NOP15	YNL110C		417825,	418488,	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis  localizes to both nucleolus and cytoplasm
chrXIV	418963	419509	418963	419509	+	YNL109W	YNL109W		418963,	419509,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YNL108C
chrXIV	419013	419826	419013	419826	-	YNL108C	YNL108C		419013,	419826,	Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes  null mutant shows alterations in glucose metabolism  GFP-fusion protein localizes to the cytoplasm and nucleus
chrXIV	420097	420778	420097	420778	+	YAF9	YNL107W		420097,	420778,	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres  interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
chrXIV	420943	424495	420943	424495	-	INP52	YNL106C		420943,	424495,	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI  involved in endocytosis  hyperosmotic stress causes translocation to actin patches  synaptojanin-like protein with a Sac1 domain
chrXIV	424154	424583	424154	424583	+	RRT16	YNL105W		424154,	424583,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene INP52  identified in a screen for mutants with decreased levels of rDNA transcription
chrXIV	424894	426754	424894	426754	-	LEU4	YNL104C		424894,	426754,	Alpha-isopropylmalate synthase (2-isopropylmalate synthase)  the main isozyme responsible for the first step in the leucine biosynthesis pathway
chrXIV	426718	426808	426718	426808	+	YNL103W-A	YNL103W-A		426718,	426808,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene MET4/YNL104C
chrXIV	427734	429753	427734	429753	+	MET4	YNL103W		427734,	429753,	Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
chrXIV	430086	434493	430086	434493	+	POL1	YNL102W		430086,	434493,	Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
chrXIV	434998	437140	434998	437140	+	AVT4	YNL101W		434998,	437140,	Vacuolar transporter, exports large neutral amino acids from the vacuole  member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
chrXIV	437612	438317	437612	438317	+	AIM37	YNL100W		437612,	438317,	Putative protein of unknown function  non-tagged protein is detected in purified mitochondria  null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome loss
chrXIV	438566	439283	438566	439283	-	OCA1	YNL099C		438566,	439283,	Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
chrXIV	439601	440570	439601	440570	-	RAS2	YNL098C		439601,	440570,	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth  farnesylation and palmitoylation required for activity and localization to plasma membrane  homolog of mammalian Ras proto-oncogenes
chrXIV	440796	440919	440796	440919	-	YNL097C-B	YNL097C-B		440796,	440919,	Putative protein of unknown function
chrXIV	441365	442358	441365	442358	-	PHO23	YNL097C		441365,	442358,	Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5  affects termination of snoRNAs and cryptic unstable transcripts (CUTs)  C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
chrXIV	441430	441586	441430	441586	+	YNL097W-A	YNL097W-A		441430,	441586,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene PHO23/YNL097C
chrXIV	443397	444315	443397	444315	-	RPS7B	YNL096C		443397,444171,	443826,444315,	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap  interacts with Kti11p  deletion causes hypersensitivity to zymocin  has similarity to rat S7 and Xenopus S8 ribosomal proteins
chrXIV	444911	446840	444911	446840	-	YNL095C	YNL095C		444911,	446840,	Putative protein of unknown function predicted to contain a transmembrane domain  YNL095C is not an essential gene
chrXIV	447610	449374	447610	449374	+	APP1	YNL094W		447610,	449374,	Protein of unknown function, interacts with Rvs161p and Rvs167p  computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
chrXIV	449867	450530	449867	450530	+	YPT53	YNL093W		449867,	450530,	Rab family GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5  required for vacuolar protein sorting and endocytosis
chrXIV	450870	452073	450870	452073	+	YNL092W	YNL092W		450870,	452073,	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family  YNL092W is not an essential gene
chrXIV	452407	456130	452407	456130	+	NST1	YNL091W		452407,	456130,	Protein of unknown function, mediates sensitivity to salt stress  interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
chrXIV	456564	457143	456564	457143	+	RHO2	YNL090W		456564,	457143,	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
chrXIV	456692	457169	456692	457169	-	YNL089C	YNL089C		456692,	457169,	Dubious open reading frame unlikely to encode a functional protein  almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
chrXIV	457703	461990	457703	461990	+	TOP2	YNL088W		457703,	461990,	Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA  cleaves complementary strands  localizes to axial cores in meiosis
chrXIV	462410	465947	462410	465947	+	TCB2	YNL087W		462410,	465947,	Bud-specific protein with a potential role in membrane trafficking  GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole  contains 3 calcium and lipid binding domains  mRNA is targeted to the bud
chrXIV	466333	466642	466333	466642	+	SNN1	YNL086W		466333,	466642,	Putative protein of unknown function  likely member of BLOC complex involved in endosomal cargo sorting  green fluorescent protein (GFP)-fusion protein localizes to endosomes
chrXIV	467130	469623	467130	469623	+	MKT1	YNL085W		467130,	469623,	Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO  involved in propagation of M2 dsRNA satellite of L-A virus  allelic variation affects mitochondrial genome stability, drug resistance, and more
chrXIV	470052	471102	470052	471102	-	END3	YNL084C		470052,	471102,	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis  forms a complex with Sla1p and Pan1p
chrXIV	471376	472861	471376	472861	+	SAL1	YNL083W		471376,	472861,	ADP/ATP transporter  member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs  transport activity of either Sal1p or Pet9p is critical for viability  polymorphic in different S. cerevisiae strains
chrXIV	473390	476012	473390	476012	+	PMS1	YNL082W		473390,	476012,	ATP-binding protein required for mismatch repair in mitosis and meiosis  functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
chrXIV	476187	476619	476187	476619	-	SWS2	YNL081C		476187,	476619,	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein  participates in controlling sporulation efficiency
chrXIV	476931	478032	476931	478032	-	EOS1	YNL080C		476931,	478032,	Protein involved in N-glycosylation  deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1  YNL080C is not an essential gene
chrXIV	478565	479165	478565	479165	-	TPM1	YNL079C		478565,	479165,	Major isoform of tropomyosin  binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles  acetylated by the NatB complex and acetylated form binds actin most efficiently
chrXIV	479767	480991	479767	480991	+	NIS1	YNL078W		479767,	480991,	Protein localized in the bud neck at G2/M phase  physically interacts with septins  possibly involved in a mitotic signaling network
chrXIV	481390	482977	481390	482977	+	APJ1	YNL077W		481390,	482977,	Putative chaperone of the HSP40 (DNAJ) family  overexpression interferes with propagation of the [Psi+] prion  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	483555	485310	483555	485310	+	MKS1	YNL076W		483555,	485310,	Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation  involved in retrograde (RTG) mitochondria-to-nucleus signaling
chrXIV	485606	486479	485606	486479	+	IMP4	YNL075W		485606,	486479,	Component of the SSU processome, which is required for pre-18S rRNA processing  interacts with Mpp10p  member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
chrXIV	486765	488124	486765	488124	-	MLF3	YNL074C		486765,	488124,	Serine-rich protein of unknown function, predicted to be palmitoylated  overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
chrXIV	488385	490116	488385	490116	+	MSK1	YNL073W		488385,	490116,	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
chrXIV	490316	491240	490316	491240	+	RNH201	YNL072W		490316,	491240,	Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication  homolog of RNAse HI  related to human AGS4 which causes Aicardi-Goutieres syndrome
chrXIV	491522	492971	491522	492971	+	LAT1	YNL071W		491522,	492971,	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
chrXIV	493365	493548	493365	493548	+	TOM7	YNL070W		493365,	493548,	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins  promotes assembly and stability of the TOM complex
chrXIV	493955	495001	493955	495001	-	RPL16B	YNL069C		493955,494973,	494524,495001,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA  has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins  transcriptionally regulated by Rap1p
chrXIV	495700	498289	495700	498289	-	FKH2	YNL068C		495700,	498289,	Forkhead family transcription factor with a major role in the expression of G2/M phase genes  positively regulates transcriptional elongation  negative role in chromatin silencing at HML and HMR  substrate of the Cdc28p/Clb5p kinase
chrXIV	498537	498684	498537	498684	+	YNL067W-A	YNL067W-A		498537,	498684,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	499416	499557	499416	499557	+	YNL067W-B	YNL067W-B		499416,	499557,	Putative protein of unknown function
chrXIV	499680	500256	499680	500256	+	RPL9B	YNL067W		499680,	500256,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins
chrXIV	501514	502777	501514	502777	+	SUN4	YNL066W		501514,	502777,	Cell wall protein related to glucanases, possibly involved in cell wall septation  member of the SUN family
chrXIV	503723	505484	503723	505484	+	AQR1	YNL065W		503723,	505484,	Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine  involved in the excretion of excess amino acids
chrXIV	505867	507097	505867	507097	-	YDJ1	YNL064C		505867,	507097,	Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions  involved in protein translocation across membranes  member of the DnaJ family
chrXIV	507757	508702	507757	508702	+	MTQ1	YNL063W		507757,	508702,	S-adenosylmethionine-dependent methyltransferase  methylates translational release factor Mrf1p  similar to E.coli PrmC  is not an essential gene
chrXIV	508775	510212	508775	510212	-	GCD10	YNL062C		508775,	510212,	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met  first identified as a negative regulator of GCN4 expression
chrXIV	510539	512396	510539	512396	+	NOP2	YNL061W		510539,	512396,	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis  localized to the nucleolus  constituent of 66S pre-ribosomal particles
chrXIV	512667	514935	512667	514935	-	ARP5	YNL059C		512667,	514935,	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
chrXIV	515762	516713	515762	516713	-	YNL058C	YNL058C		515762,	516713,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole  YNL058C is not an essential gene
chrXIV	516402	516735	516402	516735	+	YNL057W	YNL057W		516402,	516735,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	517248	517842	517248	517842	+	OCA2	YNL056W		517248,	517842,	Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YNL056W is not an essential gene
chrXIV	517993	518845	517993	518845	-	POR1	YNL055C		517993,	518845,	Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability  phosphorylated
chrXIV	519455	520778	519455	520778	+	YNL054W-A	YNL054W-A		519455,	520778,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXIV	526085	529583	526085	529583	+	VAC7	YNL054W		526085,	529583,	Integral vacuolar membrane protein involved in vacuole inheritance and morphology  activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
chrXIV	529941	531411	529941	531411	+	MSG5	YNL053W		529941,	531411,	Dual-specificity protein phosphatase  exists in 2 isoforms  required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone  regulates and is regulated by Slt2p  dephosphorylates Fus3p
chrXIV	531724	532186	531724	532186	+	COX5A	YNL052W		531724,	532186,	Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain  predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
chrXIV	532658	533870	532658	533870	+	COG5	YNL051W		532658,	533870,	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrXIV	534078	534982	534078	534982	-	YNL050C	YNL050C		534078,534965,	534874,534982,	Putative protein of unknown function  YNL050c is not an essential gene
chrXIV	535280	537911	535280	537911	-	SFB2	YNL049C		535280,	537911,	Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport  homologous to Sec24p and Sfb3p
chrXIV	538172	539819	538172	539819	+	ALG11	YNL048W		538172,	539819,	Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER
chrXIV	539910	541881	539910	541881	-	SLM2	YNL047C		539910,	541881,	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p  acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress  phosphorylated by the TORC2 complex
chrXIV	542303	542822	542303	542822	+	YNL046W	YNL046W		542303,	542822,	Putative protein of unknown function  expression depends on Swi5p  GFP-fusion protein localizes to the endoplasmic reticulum  deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
chrXIV	542962	544978	542962	544978	+	LAP2	YNL045W		542962,	544978,	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
chrXIV	545267	545877	545267	545877	+	YIP3	YNL044W		545267,545370,	545291,545877,	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport  interacts with members of the Rab GTPase family and Yip1p  also interacts with Rtn1p
chrXIV	545588	545909	545588	545909	-	YNL043C	YNL043C		545588,	545909,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YIP3/YNL044W
chrXIV	547112	547370	547112	547370	+	YNL042W-B	YNL042W-B		547112,	547370,	Putative protein of unknown function
chrXIV	548099	549290	548099	549290	+	BOP3	YNL042W		548099,	549290,	Protein of unknown function, potential Cdc28p substrate  overproduction confers resistance to methylmercury
chrXIV	549467	551987	549467	551987	-	COG6	YNL041C		549467,	551987,	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrXIV	553379	554750	553379	554750	+	YNL040W	YNL040W		553379,	554750,	Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YNL040W is not an essential gene
chrXIV	555047	556832	555047	556832	+	BDP1	YNL039W		555047,	556832,	Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
chrXIV	557019	557783	557019	557783	+	GPI15	YNL038W		557019,557684,	557610,557783,	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors  homologous to the human PIG-H protein
chrXIV	557919	559002	557919	559002	-	IDH1	YNL037C		557919,	559002,	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
chrXIV	559813	560479	559813	560479	+	NCE103	YNL036W		559813,	560479,	Carbonic anhydrase  poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions  involved in non-classical protein export pathway
chrXIV	568521	569691	568521	569691	-	YNL035C	YNL035C		568521,	569691,	Putative protein of unknown function with similarity to proteins containing WD-40 domains  green fluorescent protein (GFP)-fusion protein localizes to the nucleus  YNL035C is not an essential gene
chrXIV	570476	572315	570476	572315	+	YNL034W	YNL034W		570476,	572315,	Putative protein of unknown function  YNL034W is not an essential gene
chrXIV	572998	573853	572998	573853	+	YNL033W	YNL033W		572998,	573853,	Putative protein of unknown function
chrXIV	574505	575351	574505	575351	+	SIW14	YNL032W		574505,	575351,	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis  localized to the cytoplasm
chrXIV	575639	576050	575639	576050	-	HHT2	YNL031C		575639,	576050,	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing  one of two identical histone H3 proteins (see HHT1)  regulated by acetylation, methylation, and phosphorylation
chrXIV	576726	577038	576726	577038	+	HHF2	YNL030W		576726,	577038,	Histone H4, core histone protein required for chromatin assembly and chromosome function  one of two identical histone proteins (see also HHF1)  contributes to telomeric silencing  N-terminal domain involved in maintaining genomic integrity
chrXIV	577204	578773	577204	578773	-	KTR5	YNL029C		577204,	578773,	Putative mannosyltransferase involved in protein glycosylation  member of the KRE2/MNT1 mannosyltransferase family
chrXIV	578678	578996	578678	578996	+	YNL028W	YNL028W		578678,	578996,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXIV	579579	581616	579579	581616	+	CRZ1	YNL027W		579579,	581616,	Transcription factor that activates transcription of genes involved in stress response  nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
chrXIV	581919	583374	581919	583374	+	SAM50	YNL026W		581919,	583374,	Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion  homologous to bacterial Omp85
chrXIV	584319	585291	584319	585291	-	SSN8	YNL025C		584319,	585291,	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain  involved in glucose repression and telomere maintenance
chrXIV	586601	586820	586601	586820	-	KSH1	YNL024C-A		586601,	586820,	Essential protein suggested to function early in the secretory pathway  inviability is suppressed by overexpression of Golgi protein Tvp23p  ortholog of human Kish
chrXIV	587106	587847	587106	587847	-	YNL024C	YNL024C		587106,	587847,	Putative protein of unknown function with seven beta-strand methyltransferase motif  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YNL024C is not an essential gene
chrXIV	588262	591160	588262	591160	-	FAP1	YNL023C		588262,	591160,	Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding  accumulates in the nucleus upon treatment of cells with rapamycin  has similarity to D. melanogaster shuttle craft and human NFX1
chrXIV	591426	592899	591426	592899	-	YNL022C	YNL022C		591426,	592899,	Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W  green fluorescent protein (GFP)-fusion protein localizes to the nucleus  predicted to be involved in ribosome biogenesis
chrXIV	593226	595347	593226	595347	+	HDA1	YNL021W		593226,	595347,	Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p  Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer  deletion increases histone H2B, H3 and H4 acetylation
chrXIV	595622	597539	595622	597539	-	ARK1	YNL020C		595622,	597539,	Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton  involved in control of endocytosis
chrXIV	598375	599230	598375	599230	-	YNL019C	YNL019C		598375,	599230,	Putative protein of unknown function
chrXIV	599935	601774	599935	601774	-	YNL018C	YNL018C		599935,	601774,	Putative protein of unknown function
chrXIV	602137	602476	602137	602476	-	YNL017C	YNL017C		602137,	602476,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the tRNA ORF tI(AAU)N2
chrXIV	602906	604268	602906	604268	+	PUB1	YNL016W		602906,	604268,	Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs  component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly
chrXIV	605383	605611	605383	605611	+	PBI2	YNL015W		605383,	605611,	Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance  with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
chrXIV	606318	609453	606318	609453	+	HEF3	YNL014W		606318,	609453,	Translational elongation factor EF-3  paralog of YEF3 and member of the ABC superfamily  stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome  normally expressed in zinc deficient cells
chrXIV	609132	609510	609132	609510	-	YNL013C	YNL013C		609132,	609510,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF HEF3/YNL014W
chrXIV	609685	611665	609685	611665	+	SPO1	YNL012W		609685,609874,	609790,611665,	Meiosis-specific prospore protein  required for meiotic spindle pole body duplication and separation  required to produce bending force necessary for proper prospore membrane assembly during sporulation  has similarity to phospholipase B
chrXIV	611835	613170	611835	613170	-	YNL011C	YNL011C		611835,	613170,	Putative protein of unknown function  YNL011C is not an essential gene
chrXIV	613634	614360	613634	614360	+	YNL010W	YNL010W		613634,	614360,	Putative protein of unknown function with similarity to phosphoserine phosphatases  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  homozygous diploid mutant shows an increase in glycogen accumulation
chrXIV	614820	616083	614820	616083	+	IDP3	YNL009W		614820,	616083,	Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids
chrXIV	616210	618241	616210	618241	-	ASI3	YNL008C		616210,	618241,	Putative integral membrane E3 ubiquitin ligase  acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
chrXIV	618506	619565	618506	619565	-	SIS1	YNL007C		618506,	619565,	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p  not functionally redundant with Ydj1p due to due to substrate specificity  shares similarity with bacterial DnaJ proteins
chrXIV	620066	620978	620066	620978	+	LST8	YNL006W		620066,	620978,	Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface  component of the TOR signaling pathway  associates with both Tor1p and Tor2p  contains a WD-repeat
chrXIV	621312	622428	621312	622428	-	MRP7	YNL005C		621312,	622428,	Mitochondrial ribosomal protein of the large subunit
chrXIV	622914	624621	622914	624621	+	HRB1	YNL004W		622914,623286,	622944,624621,	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm  similar to Gbp2p and Npl3p
chrXIV	624974	625829	624974	625829	-	PET8	YNL003C		624974,	625829,	S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family  required for biotin biosynthesis and respiratory growth
chrXIV	626173	627142	626173	627142	-	RLP7	YNL002C		626173,	627142,	Nucleolar protein with similarity to large ribosomal subunit L7 proteins  constituent of 66S pre-ribosomal particles  plays an essential role in processing of precursors to the large ribosomal subunit RNAs
chrXIV	627455	628616	627455	628616	+	DOM34	YNL001W		627455,	628616,	Protein that, with binding partner Hbs1p, facilitates ribosomal subunit dissociation when translation is stalled  required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity  Pelota ortholog
chrXIV	629621	631061	629621	631061	-	CIT1	YNR001C		629621,	631061,	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate  the rate-limiting enzyme of the TCA cycle  nuclear encoded mitochondrial protein
chrXIV	631262	631481	631262	631481	+	YNR001W-A	YNR001W-A		631262,	631481,	Dubious open reading frame unlikely to encode a functional protein  identified by homology
chrXIV	633007	633856	633007	633856	-	ATO2	YNR002C		633007,	633856,	Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies  phosphorylated in mitochondria  member of the TC 9.B.33 YaaH family  homolog of Ady2p and Y. lipolytica Gpr1p
chrXIV	634343	635297	634343	635297	-	RPC34	YNR003C		634343,	635297,	RNA polymerase III subunit C34  interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
chrXIV	634419	634518	634419	634518	+	YNR003W-A	YNR003W-A		634419,	634518,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene RPC34/YNR003C
chrXIV	635942	636383	635942	636383	+	SWM2	YNR004W		635942,	636383,	Putative protein of unknown function  haploid disruptant exhibits cold-sensitive growth and elongated buds
chrXIV	636930	637335	636930	637335	-	YNR005C	YNR005C		636930,	637335,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXIV	636985	638854	636985	638854	+	VPS27	YNR006W		636985,	638854,	Endosomal protein that forms a complex with Hse1p  required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation  has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
chrXIV	639181	640114	639181	640114	-	ATG3	YNR007C		639181,	640114,	E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway  plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt
chrXIV	640395	642381	640395	642381	+	LRO1	YNR008W		640395,	642381,	Acyltransferase that catalyzes diacylglycerol esterification  one of several acyltransferases that contribute to triglyceride synthesis  putative homolog of human lecithin cholesterol acyltransferase
chrXIV	642689	643439	642689	643439	+	NRM1	YNR009W		642689,	643439,	Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression  Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
chrXIV	643743	644193	643743	644193	+	CSE2	YNR010W		643743,	644193,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  component of the Middle domain of mediator  required for regulation of RNA polymerase II activity
chrXIV	644319	646950	644319	646950	-	PRP2	YNR011C		644319,	646950,	RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing  orthologous to human protein DHX16
chrXIV	647431	648937	647431	648937	+	URK1	YNR012W		647431,	648937,	Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP  involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
chrXIV	649027	651712	649027	651712	-	PHO91	YNR013C		649027,	651712,	Low-affinity phosphate transporter of the vacuolar membrane  deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality  transcription independent of Pi and Pho4p activity  overexpression results in vigorous growth
chrXIV	652464	653103	652464	653103	+	YNR014W	YNR014W		652464,	653103,	Putative protein of unknown function  expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
chrXIV	653386	654541	653386	654541	+	SMM1	YNR015W		653386,	654541,	Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p  modifies uridine residues at position 20 of cytoplasmic tRNAs
chrXIV	654672	661374	654672	661374	-	ACC1	YNR016C		654672,	661374,	Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA  required for de novo biosynthesis of long-chain fatty acids
chrXIV	662912	663581	662912	663581	+	TIM23	YNR017W		662912,	663581,	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  involved in protein import into mitochondrial matrix and inner membrane  with Tim17p, contributes to architecture and function of the import channel
chrXIV	664269	664944	664269	664944	+	AIM38	YNR018W		664269,	664944,	Putative protein of unknown function  non-tagged protein is detected in purified mitochondria  may interact with respiratory chain complex IV  null mutant is viable and displays reduced frequency of mitochondrial genome loss
chrXIV	665338	667267	665338	667267	+	ARE2	YNR019W		665338,	667267,	Acyl-CoA:sterol acyltransferase, isozyme of Are1p  endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
chrXIV	667409	668222	667409	668222	-	ATP23	YNR020C		667409,	668222,	Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p  has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex
chrXIV	668376	669591	668376	669591	+	YNR021W	YNR021W		668376,	669591,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum  YNR021W is not an essential gene
chrXIV	669773	670193	669773	670193	-	MRPL50	YNR022C		669773,	670193,	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
chrXIV	670417	672118	670417	672118	+	SNF12	YNR023W		670417,	672118,	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation  homolog of Rsc6p subunit of the RSC chromatin remodeling complex  deletion mutants are temperature-sensitive
chrXIV	672408	672969	672408	672969	+	MPP6	YNR024W		672408,	672969,	Nuclear exosome-associated RNA binding protein  involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA)  copurifies with ribosomes
chrXIV	672701	673061	672701	673061	-	YNR025C	YNR025C		672701,	673061,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase
chrXIV	673273	674689	673273	674689	-	SEC12	YNR026C		673273,	674689,	Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP  required for the initiation of COPII vesicle formation in ER to Golgi transport  glycosylated integral membrane protein of the ER
chrXIV	674922	675876	674922	675876	+	BUD17	YNR027W		674922,	675876,	Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism  involved in bud-site selection  diploid mutants display a random rather than a bipolar budding pattern  similarity to yeast BUD16 and human pyridoxal kinase (PDXK)
chrXIV	676176	677103	676176	677103	+	CPR8	YNR028W		676176,	677103,	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues  similarity to Cpr4p suggests a potential role in the secretory pathway
chrXIV	677198	678488	677198	678488	-	YNR029C	YNR029C		677198,	678488,	Putative protein of unknown function, deletion confers reduced fitness in saline
chrXIV	678798	680454	678798	680454	+	ALG12	YNR030W		678798,	680454,	Alpha-1,6-mannosyltransferase localized to the ER  responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
chrXIV	680693	685433	680693	685433	-	SSK2	YNR031C		680693,	685433,	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway  interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p  also mediates actin cytoskeleton recovery from osmotic stress
chrXIV	686009	687116	686009	687116	+	PPG1	YNR032W		686009,	687116,	Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation  interacts with Tap42p, which binds to and regulates other protein phosphatases
chrXIV	687242	687464	687242	687464	-	HUB1	YNR032C-A		687242,	687464,	Ubiquitin-like protein modifier  promotes alternative splicing of SRC1 pre-mRNA  binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog  mechanism of Hub1p adduct formation not yet clear
chrXIV	687634	689998	687634	689998	+	ABZ1	YNR033W		687634,	689998,	Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB  required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis
chrXIV	690320	691286	690320	691286	+	SOL1	YNR034W		690320,	691286,	Protein with a possible role in tRNA export  shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity  homologous to Sol2p, Sol3p, and Sol4p
chrXIV	692560	692857	692560	692857	+	YNR034W-A	YNR034W-A		692560,	692857,	Putative protein of unknown function  expression is regulated by Msn2p/Msn4p
chrXIV	693018	694047	693018	694047	-	ARC35	YNR035C		693018,	694047,	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches  required for cortical localization of calmodulin
chrXIV	694360	694822	694360	694822	-	MRPS12	YNR036C		694360,	694822,	Mitochondrial protein  may interact with ribosomes based on co-purification experiments  similar to E. coli and human mitochondrial S12 ribosomal proteins
chrXIV	695051	695327	695051	695327	-	RSM19	YNR037C		695051,	695327,	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
chrXIV	695594	697484	695594	697484	+	DBP6	YNR038W		695594,	697484,	Essential protein involved in ribosome biogenesis  putative ATP-dependent RNA helicase of the DEAD-box protein family
chrXIV	697613	699431	697613	699431	-	ZRG17	YNR039C		697613,	699431,	Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency  mutant phenotype suggests a role in uptake of zinc
chrXIV	699689	700460	699689	700460	+	YNR040W	YNR040W		699689,	700460,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	700540	701659	700540	701659	-	COQ2	YNR041C		700540,	701659,	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
chrXIV	701237	701666	701237	701666	+	YNR042W	YNR042W		701237,	701666,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps verified gene COQ2
chrXIV	701894	703085	701894	703085	+	MVD1	YNR043W		701894,	703085,	Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol  acts as a homodimer
chrXIV	703698	705876	703698	705876	+	AGA1	YNR044W		703698,	705876,	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
chrXIV	706138	707608	706138	707608	+	PET494	YNR045W		706138,	707608,	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p  located in the mitochondrial inner membrane
chrXIV	707787	708195	707787	708195	+	TRM112	YNR046W		707787,	708195,	Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p  subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP  deletion confers resistance to zymocin
chrXIV	708522	711204	708522	711204	+	FPK1	YNR047W		708522,	711204,	Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p  phosphorylates and inhibits upstream inhibitory kinase, Ypk1p  localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane
chrXIV	711629	712811	711629	712811	+	YNR048W	YNR048W		711629,	712811,	Protein that interacts specifically in vivo with phospholipid translocase (flippase) Dnf3p  similar to Cdc50p, which is an essential interaction partner of the flippase Drs2p
chrXIV	713022	713655	713022	713655	-	MSO1	YNR049C		713022,	713655,	Probable component of the secretory vesicle docking complex, acts at a late step in secretion  shows genetic and physical interactions with Sec1p  required for prospore membrane formation during sporulation
chrXIV	714047	715388	714047	715388	-	LYS9	YNR050C		714047,	715388,	Saccharopine dehydrogenase (NADP+, L-glutamate-forming)  catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway  exhibits genetic and physical interactions with TRM112
chrXIV	716779	718327	716779	718327	-	BRE5	YNR051C		716779,	718327,	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments  null is sensitive to brefeldin A
chrXIV	719345	720647	719345	720647	-	POP2	YNR052C		719345,	720647,	RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
chrXIV	721119	723112	721119	723112	-	NOG2	YNR053C		721119,722302,	721770,723112,	Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
chrXIV	723355	724306	723355	724306	-	ESF2	YNR054C		723355,	724306,	Essential nucleolar protein involved in pre-18S rRNA processing  binds to RNA and stimulates ATPase activity of Dbp8  involved in assembly of the small subunit (SSU) processome
chrXIV	728425	730186	728425	730186	-	HOL1	YNR055C		728425,	730186,	Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters  mutations in membrane-spanning domains permit cation and histidinol uptake
chrXIV	731617	733303	731617	733303	-	BIO5	YNR056C		731617,	733303,	Putative transmembrane protein involved in the biotin biosynthesis pathway  responsible for uptake of 7-keto 8-aminopelargonic acid  BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
chrXIV	733355	734069	733355	734069	-	BIO4	YNR057C		733355,	734069,	Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway  BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis  expression appears to be repressed at low iron levels
chrXIV	734290	735733	734290	735733	+	BIO3	YNR058W		734290,	735733,	7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway  BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
chrXIV	736802	738545	736802	738545	+	MNT4	YNR059W		736802,	738545,	Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation
chrXIV	739950	742110	739950	742110	+	FRE4	YNR060W		739950,	742110,	Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters  expression induced by low iron levels
chrXIV	742880	743540	742880	743540	-	YNR061C	YNR061C		742880,	743540,	Putative protein of unknown function
chrXIV	744359	745343	744359	745343	-	YNR062C	YNR062C		744359,	745343,	Putative membrane protein of unknown function
chrXIV	746942	748766	746942	748766	+	YNR063W	YNR063W		746942,	748766,	Putative zinc-cluster protein of unknown function
chrXIV	749135	750008	749135	750008	-	YNR064C	YNR064C		749135,	750008,	Epoxide hydrolase, member of the alpha/beta hydrolase fold family  may have a role in detoxification of epoxides
chrXIV	750349	753700	750349	753700	-	YNR065C	YNR065C		750349,	753700,	Protein of unknown function  protein-protein interactions suggest a possible role in actin patch formation  YNR065C is not an essential gene
chrXIV	753724	755035	753724	755035	-	YNR066C	YNR066C		753724,	755035,	Putative membrane-localized protein of unknown function
chrXIV	755745	759099	755745	759099	-	DSE4	YNR067C		755745,	759099,	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
chrXIV	760066	760885	760066	760885	-	YNR068C	YNR068C		760066,	760885,	Putative protein of unknown function
chrXIV	761122	762592	761122	762592	-	BSC5	YNR069C		761122,	762592,	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
chrXIV	765374	769376	765374	769376	+	PDR18	YNR070W		765374,	769376,	Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXIV	770439	771468	770439	771468	-	YNR071C	YNR071C		770439,	771468,	Putative protein of unknown function
chrXIV	772656	774351	772656	774351	+	HXT17	YNR072W		772656,	774351,	Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
chrXIV	774791	776300	774791	776300	-	YNR073C	YNR073C		774791,	776300,	Putative mannitol dehydrogenase
chrXIV	777601	778738	777601	778738	-	AIF1	YNR074C		777601,	778738,	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
chrXIV	779915	781040	779915	781040	+	COS10	YNR075W		779915,	781040,	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
chrXIV	781510	781603	781510	781603	-	YNR075C-A	YNR075C-A		781510,	781603,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXIV	781917	782280	781917	782280	+	PAU6	YNR076W		781917,	782280,	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme  identical to Pau18p
chrXIV	783286	783541	783286	783541	-	YNR077C	YNR077C		783286,	783541,	Protein of unknown function, abundance changes with carbon source
chrXV	584	740	584	740	+	YOL166W-A	YOL166W-A		584,	740,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	999	1338	999	1338	-	YOL166C	YOL166C		999,	1338,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	1646	2078	1646	2078	-	AAD15	YOL165C		1646,	2078,	Putative aryl-alcohol dehydrogenase  similar to P. chrysosporium aryl-alcohol dehydrogenase  mutational analysis has not yet revealed a physiological role
chrXV	4129	4312	4129	4312	+	YOL164W-A	YOL164W-A		4129,	4312,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXV	6174	8115	6174	8115	+	BDS1	YOL164W		6174,	8115,	Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources
chrXV	9596	10106	9596	10106	+	YOL163W	YOL163W		9596,	10106,	Putative protein of unknown function  member of the Dal5p subfamily of the major facilitator family
chrXV	10118	10766	10118	10766	+	YOL162W	YOL162W		10118,	10766,	Putative protein of unknown function  member of the Dal5p subfamily of the major facilitator family
chrXV	11548	11911	11548	11911	-	PAU20	YOL161C		11548,	11911,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions  expression induced by low temperature and also by anaerobic conditions  induced during alcoholic fermentation
chrXV	14312	14654	14312	14654	+	YOL160W	YOL160W		14312,	14654,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXV	15232	15505	15232	15505	-	YOL159C-A	YOL159C-A		15232,	15505,	Protein of unknown function  overexpression affects endocytic protein trafficking  identified by sequence comparison with hemiascomycetous yeast species
chrXV	17280	17796	17280	17796	-	YOL159C	YOL159C		17280,	17796,	Soluble protein of unknown function  deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
chrXV	19490	21311	19490	21311	-	ENB1	YOL158C		19490,	21311,	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation  member of the major facilitator superfamily  expression is regulated by Rcs1p and affected by chloroquine treatment
chrXV	22524	24294	22524	24294	-	IMA2	YOL157C		22524,	24294,	Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose  member of IMA isomaltase family  not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose
chrXV	25272	26976	25272	26976	+	HXT11	YOL156W		25272,	26976,	Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
chrXV	27083	27218	27083	27218	+	YOL155W-A	YOL155W-A		27083,	27218,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXV	28702	31606	28702	31606	-	HPF1	YOL155C		28702,	31606,	Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
chrXV	34657	35407	34657	35407	+	ZPS1	YOL154W		34657,	35407,	Putative GPI-anchored protein  transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
chrXV	40747	42610	40747	42610	+	FRE7	YOL152W		40747,	42610,	Putative ferric reductase with similarity to Fre2p  expression induced by low copper levels
chrXV	43693	44722	43693	44722	+	GRE2	YOL151W		43693,	44722,	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase)  stress induced (osmotic, ionic, oxidative, heat shock and heavy metals)  regulated by the HOG pathway
chrXV	44472	44784	44472	44784	-	YOL150C	YOL150C		44472,	44784,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	44937	45633	44937	45633	+	DCP1	YOL149W		44937,	45633,	Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation  enhances the activity of catalytic subunit Dcp2p  regulated by DEAD box protein Dhh1p
chrXV	45759	47574	45759	47574	-	SPT20	YOL148C		45759,	47574,	Subunit of the SAGA transcriptional regulatory complex  involved in maintaining the integrity of the complex  mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
chrXV	47932	48643	47932	48643	-	PEX11	YOL147C		47932,	48643,	Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature  localization regulated by phosphorylation  transcription regulated by Adr1p and Pip2p-Oaf1p
chrXV	48863	49448	48863	49448	+	PSF3	YOL146W		48863,	49448,	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
chrXV	49554	52788	49554	52788	-	CTR9	YOL145C		49554,	52788,	Component of the Paf1p complex  binds to and modulates the activity of RNA polymerases I and II  required for expression of a subset of genes, including cyclin genes  contains TPR repeats  possibly involved in transcription elongation as a component of the PAF complex
chrXV	53097	54552	53097	54552	+	NOP8	YOL144W		53097,	54552,	Nucleolar protein required for 60S ribosomal subunit biogenesis
chrXV	54594	55104	54594	55104	-	RIB4	YOL143C		54594,	55104,	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase)  catalyzes synthesis of immediate precursor to riboflavin
chrXV	55557	56280	55557	56280	+	RRP40	YOL142W		55557,	56280,	Exosome non-catalytic core component  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  predicted to contain both S1 and KH RNA binding domains  has similarity to human hRrp40p (EXOSC3)
chrXV	56451	58539	56451	58539	+	PPM2	YOL141W		56451,	58539,	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation  required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA  similarity to Ppm1p
chrXV	58758	60030	58758	60030	+	ARG8	YOL140W		58758,	60030,	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
chrXV	60382	61024	60382	61024	-	CDC33	YOL139C		60382,	61024,	Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E  the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)
chrXV	61324	65350	61324	65350	-	RTC1	YOL138C		61324,	65350,	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole  null mutation suppresses cdc13-1 temperature sensitivity  has N-terminal WD-40 repeats and a C-terminal RING motif
chrXV	65620	67114	65620	67114	+	BSC6	YOL137W		65620,	67114,	Protein of unknown function containing 8 putative transmembrane seqments  ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
chrXV	67560	68754	67560	68754	-	PFK27	YOL136C		67560,	68754,	6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate  inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
chrXV	69375	70044	69375	70044	-	MED7	YOL135C		69375,	70044,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation
chrXV	70155	70545	70155	70545	-	YOL134C	YOL134C		70155,	70545,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
chrXV	70324	70690	70324	70690	+	HRT1	YOL133W		70324,	70690,	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF)  required for Gic2p, Far1p, Sic1p and Cln2p degradation  may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
chrXV	71299	72715	71299	72715	+	GAS4	YOL132W		71299,	72715,	1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly  has similarity to Gas1p  localizes to the cell wall
chrXV	73030	73357	73030	73357	+	YOL131W	YOL131W		73030,	73357,	Putative protein of unknown function
chrXV	74399	76979	74399	76979	+	ALR1	YOL130W		74399,	76979,	Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration  overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
chrXV	77559	78114	77559	78114	+	VPS68	YOL129W		77559,	78114,	Vacuolar membrane protein of unknown function involved in vacuolar protein sorting  also detected in the mitochondria
chrXV	78351	79479	78351	79479	-	YGK3	YOL128C		78351,	79479,	Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family  GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
chrXV	80347	81190	80347	81190	+	RPL25	YOL127W		80347,80774,	80360,81190,	Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins  binds to 25S rRNA via a conserved C-terminal motif
chrXV	81786	82920	81786	82920	-	MDH2	YOL126C		81786,	82920,	Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate  involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds  interacts with Pck1p and Fbp1
chrXV	83833	85264	83833	85264	+	TRM13	YOL125W		83833,	85264,	2'-O-methyltransferase responsible for modification of tRNA at position 4  C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
chrXV	85455	86757	85455	86757	-	TRM11	YOL124C		85455,	86757,	Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs  contains a THUMP domain and a methyltransferase domain
chrXV	87843	89448	87843	89448	+	HRP1	YOL123W		87843,	89448,	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends  RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
chrXV	89691	91419	89691	91419	-	SMF1	YOL122C		89691,	91419,	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals  post-translationally regulated by levels of metal ions  member of the Nramp family of metal transport proteins
chrXV	92025	92850	92025	92850	-	RPS19A	YOL121C		92025,92830,	92440,92850,	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles  mutations in human RPS19 are associated with Diamond Blackfan anemia  nearly identical to Rps19Bp
chrXV	93394	94402	93394	94402	-	RPL18A	YOL120C		93394,94290,	93843,94402,	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein  intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
chrXV	94855	96361	94855	96361	-	MCH4	YOL119C		94855,	96361,	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane  mutant is not deficient in monocarboxylate transport
chrXV	96607	96916	96607	96916	-	YOL118C	YOL118C		96607,	96916,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	97550	99488	97550	99488	+	RRI2	YOL117W		97550,	99488,	Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases  plays a role in the mating pheromone response
chrXV	99808	100957	99808	100957	+	MSN1	YOL116W		99808,	100957,	Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress  localizes to the nucleus
chrXV	101474	103229	101474	103229	+	PAP2	YOL115W		101474,	103229,	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex  catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors  overlapping but non-redundant functions with Trf5p
chrXV	103316	103925	103316	103925	-	YOL114C	YOL114C		103316,	103925,	Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination  YOL114C is not an essential gene
chrXV	104325	106293	104325	106293	+	SKM1	YOL113W		104325,	106293,	Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p  involved in down-regulation of sterol uptake  proposed to be a downstream effector of Cdc42p during polarized growth
chrXV	106709	108188	106709	108188	+	MSB4	YOL112W		106709,	108188,	GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p  msb3 msb4 double mutation causes defects in secretion and actin organization
chrXV	108257	108896	108257	108896	-	MDY2	YOL111C		108257,	108896,	Protein with a role in insertion of tail-anchored proteins into the ER membrane  forms a complex with Get4p  required for efficient mating  involved in shmoo formation and nuclear migration in the pre-zygote  associates with ribosomes
chrXV	109175	109889	109175	109889	+	SHR5	YOL110W		109175,	109889,	Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage  palmitoylation is required for Ras2p membrane localization
chrXV	110296	110638	110296	110638	+	ZEO1	YOL109W		110296,	110638,	Peripheral membrane protein of the plasma membrane that interacts with Mid2p  regulates the cell integrity pathway mediated by Pkc1p and Slt2p  the authentic protein is detected in a phosphorylated state in highly purified mitochondria
chrXV	111430	111886	111430	111886	-	INO4	YOL108C		111430,	111886,	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis  forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
chrXV	112101	113130	112101	113130	+	YOL107W	YOL107W		112101,	113130,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles  YOL107W is not an essential protein
chrXV	113225	113579	113225	113579	+	YOL106W	YOL106W		113225,	113579,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	114137	115808	114137	115808	-	WSC3	YOL105C		114137,	115808,	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity  involved in the response to heat shock and other stressors  regulates 1,3-beta-glucan synthesis
chrXV	116395	117454	116395	117454	-	NDJ1	YOL104C		116395,	117454,	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
chrXV	117999	123268	117999	123268	+	YOL103W-B	YOL103W-B		117999,119305,	119304,123268,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXV	117999	119322	117999	119322	+	YOL103W-A	YOL103W-A		117999,	119322,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXV	124000	125830	124000	125830	+	ITR2	YOL103W		124000,	125830,	Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily  expressed constitutively
chrXV	125996	126689	125996	126689	-	TPT1	YOL102C		125996,	126689,	tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
chrXV	126981	127920	126981	127920	-	IZH4	YOL101C		126981,	127920,	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels  deletion reduces sensitivity to excess zinc  possible role in sterol metabolism
chrXV	129236	132482	129236	132482	+	PKH2	YOL100W		129236,	132482,	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis  activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity  redundant with Pkh1p
chrXV	132016	132508	132016	132508	-	YOL099C	YOL099C		132016,	132508,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene PKH2/YOL100W  may interact with ribosomes
chrXV	132724	135838	132724	135838	-	YOL098C	YOL098C		132724,	135838,	Putative metalloprotease
chrXV	136219	136405	136219	136405	+	YOL097W-A	YOL097W-A		136219,	136405,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXV	136526	137825	136526	137825	-	WRS1	YOL097C		136526,	137825,	Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
chrXV	138106	139045	138106	139045	-	COQ3	YOL096C		138106,	139045,	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis  component of a mitochondrial ubiquinone-synthesizing complex  phosphoprotein
chrXV	139226	141347	139226	141347	-	HMI1	YOL095C		139226,	141347,	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome  not required for mitochondrial transcription  has homology to E. coli helicase uvrD
chrXV	141583	142555	141583	142555	-	RFC4	YOL094C		141583,	142555,	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
chrXV	142814	143696	142814	143696	+	TRM10	YOL093W		142814,	143696,	tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs
chrXV	144203	145130	144203	145130	+	YOL092W	YOL092W		144203,	145130,	Putative protein of unknown function  predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W
chrXV	145333	147163	145333	147163	+	SPO21	YOL091W		145333,	147163,	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
chrXV	147381	150276	147381	150276	+	MSH2	YOL090W		147381,	150276,	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process  contains a Walker ATP-binding motif required for repair activity  Msh2p-Msh6p binds to and hydrolyzes ATP
chrXV	150397	153490	150397	153490	-	HAL9	YOL089C		150397,	153490,	Putative transcription factor containing a zinc finger  overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression
chrXV	153911	154745	153911	154745	-	MPD2	YOL088C		153911,	154745,	Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity  overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions  undergoes oxidation by Ero1p
chrXV	155286	158637	155286	158637	-	YOL087C	YOL087C		155286,	158637,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
chrXV	159172	159445	159172	159445	+	YOL086W-A	YOL086W-A		159172,	159445,	Putative protein of unknown function  mutant in a srs2 mutant background displays MMS hypersensitivity  ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability
chrXV	159547	160594	159547	160594	-	ADH1	YOL086C		159547,	160594,	Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers  required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
chrXV	161578	161791	161578	161791	+	YOL085W-A	YOL085W-A		161578,	161791,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORF YOL085C
chrXV	161672	162014	161672	162014	-	YOL085C	YOL085C		161672,	162014,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the dubious gene YOL085W-A
chrXV	162355	165331	162355	165331	+	PHM7	YOL084W		162355,	165331,	Protein of unknown function, expression is regulated by phosphate levels  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
chrXV	165713	166952	165713	166952	+	ATG34	YOL083W		165713,	166952,	Receptor protein involved in selective autophagy during starvation  specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p)  Atg19p paralog
chrXV	166460	166601	166460	166601	-	YOL083C-A	YOL083C-A		166460,	166601,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  identified by expression profiling and mass spectrometry
chrXV	168726	169974	168726	169974	+	ATG19	YOL082W		168726,	169974,	Receptor protein specific for the cytoplasm-to-vacuole targeting (Cvt) pathway  delivers cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
chrXV	171069	180309	171069	180309	+	IRA2	YOL081W		171069,	180309,	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
chrXV	180557	181427	180557	181427	-	REX4	YOL080C		180557,	181427,	Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
chrXV	181056	181455	181056	181455	+	YOL079W	YOL079W		181056,	181455,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	181681	185212	181681	185212	+	AVO1	YOL078W		181681,	185212,	Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
chrXV	185437	185644	185437	185644	+	ATP19	YOL077W-A		185437,	185644,	Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis  associated only with the dimeric form of ATP synthase
chrXV	185847	186723	185847	186723	-	BRX1	YOL077C		185847,	186723,	Nucleolar protein, constituent of 66S pre-ribosomal particles  depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits  possesses a sigma(70)-like RNA-binding motif
chrXV	187023	189414	187023	189414	+	MDM20	YOL076W		187023,	189414,	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences  involved in mitochondrial inheritance and actin assembly
chrXV	189657	193542	189657	193542	-	YOL075C	YOL075C		189657,	193542,	Putative ABC transporter
chrXV	193831	194800	193831	194800	-	YOL073C	YOL073C		193831,	194800,	Putative protein of unknown function
chrXV	194969	196337	194969	196337	+	THP1	YOL072W		194969,	196337,	Nuclear pore-associated protein  component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus  involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP  contains a PAM domain implicated in protein-protein binding
chrXV	196506	196995	196506	196995	+	EMI5	YOL071W		196506,	196995,	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction  required for FAD cofactor attachment to Sdh1p  mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
chrXV	197219	198725	197219	198725	-	NBA1	YOL070C		197219,	198725,	Protein of unknown function, localizes to the bud neck and cytoplasm  interacts with Nap1p  may interact with ribosomes, based on co-purification experiments  potential Cdc28p substrate
chrXV	198941	200297	198941	200297	+	NUF2	YOL069W		198941,	200297,	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p)  involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
chrXV	200367	201879	200367	201879	-	HST1	YOL068C		200367,	201879,	NAD(+)-dependent histone deacetylase  essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression  non-essential subunit of the Set3C deacetylase complex  involved in telomere maintenance
chrXV	201984	202518	201984	202518	-	RTG1	YOL067C		201984,	202518,	Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
chrXV	202695	204471	202695	204471	-	RIB2	YOL066C		202695,	204471,	Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity  the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
chrXV	204730	205885	204730	205885	-	INP54	YOL065C		204730,	205885,	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail  lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
chrXV	206102	207176	206102	207176	-	MET22	YOL064C		206102,	207176,	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis  dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
chrXV	207391	210265	207391	210265	-	CRT10	YOL063C		207391,	210265,	Protein involved in transcriptional regulation of RNR2 and RNR3  expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea  N-terminal region has a leucine repeat and a WD40 repeat
chrXV	210519	211995	210519	211995	-	APM4	YOL062C		210519,	211995,	Mu2-like subunit of the clathrin associated protein complex (AP-2)  involved in vesicle transport
chrXV	212243	213734	212243	213734	+	PRS5	YOL061W		212243,	213734,	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis  one of five related enzymes, which are active as heteromultimeric complexes
chrXV	214016	216137	214016	216137	-	MAM3	YOL060C		214016,	216137,	Protein required for normal mitochondrial morphology, has similarity to hemolysins
chrXV	217125	218448	217125	218448	+	GPD2	YOL059W		217125,	218448,	NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions  located in cytosol and mitochondria
chrXV	219210	220473	219210	220473	+	ARG1	YOL058W		219210,	220473,	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway  potential Cdc28p substrate
chrXV	220766	222902	220766	222902	+	YOL057W	YOL057W		220766,	222902,	Dipeptidyl-peptidase III  cleaves dipeptides from the amino terminus of target proteins  highly active on synthetic substrate Arg-Arg-2-naphthylamide  mammalian ortholog may be a biomarker for some cancers
chrXV	223267	224179	223267	224179	+	GPM3	YOL056W		223267,	224179,	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis  may be non-functional derivative of a gene duplication event
chrXV	224419	226075	224419	226075	-	THI20	YOL055C		224419,	226075,	Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities  involved in thiamine biosynthesis and degradation  in a gene family with THI21 and THI22  HMP-P kinase activity redundant with Thi21p
chrXV	228613	229834	228613	229834	+	PSH1	YOL054W		228613,	229834,	E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin  ubiquitylation of Cse4p may be antagonized by Scm3p
chrXV	230084	231272	230084	231272	+	AIM39	YOL053W		230084,	231272,	Putative protein of unknown function  null mutant displays elevated frequency of mitochondrial genome loss
chrXV	231569	231755	231569	231755	-	DDR2	YOL052C-A		231569,	231755,	Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
chrXV	232445	233636	232445	233636	-	SPE2	YOL052C		232445,	233636,	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine  cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
chrXV	234939	238185	234939	238185	+	GAL11	YOL051W		234939,	238185,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  affects transcription by acting as target of activators and repressors  forms part of the tail domain of mediator
chrXV	237881	238202	237881	238202	-	YOL050C	YOL050C		237881,	238202,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps verified gene GAL11  deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
chrXV	238618	240094	238618	240094	+	GSH2	YOL049W		238618,	240094,	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine  induced by oxidative stress and heat shock
chrXV	240203	241310	240203	241310	-	RRT8	YOL048C		240203,241025,	240947,241310,	Putative protein of unknown function  identified in a screen for mutants with increased levels of rDNA transcription  green fluorescent protein (GFP)-fusion protein localizes to lipid particles
chrXV	241613	242747	241613	242747	-	YOL047C	YOL047C		241613,242504,	242441,242747,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrXV	243465	244140	243465	244140	-	YOL046C	YOL046C		243465,	244140,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data almost completely overlaps the verified gene PSK2/YOL045W
chrXV	243496	246802	243496	246802	+	PSK2	YOL045W		243496,	246802,	One of two (see also PSK1) PAS domain containing S/T protein kinases  regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)
chrXV	247149	248301	247149	248301	+	PEX15	YOL044W		247149,	248301,	Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
chrXV	248391	249534	248391	249534	-	NTG2	YOL043C		248391,	249534,	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus  sumoylated
chrXV	249824	250916	249824	250916	+	NGL1	YOL042W		249824,	250916,	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXV	251266	252646	251266	252646	-	NOP12	YOL041C		251266,	252646,	Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit  contains an RNA recognition motif (RRM)  binds to Ebp2  similar to Nop13p and Nsr1p
chrXV	253148	253577	253148	253577	-	RPS15	YOL040C		253148,	253577,	Protein component of the small (40S) ribosomal subunit  has similarity to E. coli S19 and rat S15 ribosomal proteins
chrXV	254296	254617	254296	254617	+	RPP2A	YOL039W		254296,	254617,	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome  regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
chrXV	254925	255021	254925	255021	-	YOL038C-A	YOL038C-A		254925,	255021,	Putative protein of unknown function  identified by SAGE analysis
chrXV	255336	256101	255336	256101	+	PRE6	YOL038W		255336,	256101,	Alpha 4 subunit of the 20S proteasome  may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform  GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
chrXV	256665	257019	256665	257019	-	YOL037C	YOL037C		256665,	257019,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YOL036W
chrXV	256744	259030	256744	259030	+	YOL036W	YOL036W		256744,	259030,	Protein of unknown function  potential Cdc28p substrate
chrXV	258802	259105	258802	259105	-	YOL035C	YOL035C		258802,	259105,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	259922	263204	259922	263204	+	SMC5	YOL034W		259922,	263204,	Structural maintenance of chromosomes (SMC) protein  essential subunit of the Mms21-Smc5-Smc6 complex  required for growth and DNA repair  S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
chrXV	263474	265085	263474	265085	+	MSE1	YOL033W		263474,	265085,	Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated
chrXV	265428	266169	265428	266169	+	OPI10	YOL032W		265428,	266169,	Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
chrXV	266263	267529	266263	267529	-	SIL1	YOL031C		266263,	267529,	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER  homolog of Yarrowia lipolytica SLS1  GrpE-like protein
chrXV	268186	269641	268186	269641	+	GAS5	YOL030W		268186,	269641,	1,3-beta-glucanosyltransferase, has similarity to Gas1p  localizes to the cell wall
chrXV	269814	270420	269814	270420	-	YOL029C	YOL029C		269814,	270420,	Putative protein of unknown function  identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
chrXV	270632	271370	270632	271370	-	YAP7	YOL028C		270632,	271370,	Putative basic leucine zipper (bZIP) transcription factor
chrXV	272002	273724	272002	273724	-	MDM38	YOL027C		272002,	273724,	Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes  roles in protein export and K+/H+ exchange  human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
chrXV	274011	274353	274011	274353	-	MIM1	YOL026C		274011,	274353,	Mitochondrial outer membrane protein, involved in the insertion of TOM (translocase of outer membrane) complex components into the membrane and required for assembly of the TOM complex  mutants display impaired mitochondrial protein import
chrXV	274956	276939	274956	276939	+	LAG2	YOL025W		274956,	276939,	Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p  longevity determinant that is preferentially expressed in young cells  similar to mammalian Cand1
chrXV	277085	277604	277085	277604	+	YOL024W	YOL024W		277085,	277604,	Putative protein of unknown function  predicted to have thiol-disulfide oxidoreductase active site
chrXV	278055	280086	278055	280086	+	IFM1	YOL023W		278055,	280086,	Mitochondrial translation initiation factor 2
chrXV	280271	281498	280271	281498	-	TSR4	YOL022C		280271,	281498,	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA  essential gene in S288C background but not in CEN.PK2
chrXV	282420	285426	282420	285426	-	DIS3	YOL021C		282420,	285426,	Exosome core complex catalytic subunit  possesses both endonuclease and 3'-5' exonuclease activity  involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm  has similarity to E. coli RNase R and to human DIS3
chrXV	286171	287950	286171	287950	+	TAT2	YOL020W		286171,	287950,	High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
chrXV	288419	288572	288419	288572	+	YOL019W-A	YOL019W-A		288419,	288572,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	288897	290553	288897	290553	+	YOL019W	YOL019W		288897,	290553,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
chrXV	290880	292074	290880	292074	-	TLG2	YOL018C		290880,	292074,	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi  binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation  homologous to mammalian SNARE protein syntaxin 16 (Sx16)
chrXV	292528	294673	292528	294673	+	ESC8	YOL017W		292528,	294673,	Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex
chrXV	294776	296120	294776	296120	-	CMK2	YOL016C		294776,	296120,	Calmodulin-dependent protein kinase  may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
chrXV	297077	298838	297077	298838	+	IRC10	YOL015W		297077,	298838,	Putative protein of unknown function  null mutant displays increased levels of spontaneous Rad52p foci
chrXV	299692	300067	299692	300067	+	YOL014W	YOL014W		299692,	300067,	Putative protein of unknown function
chrXV	300689	300980	300689	300980	+	YOL013W-B	YOL013W-B		300689,	300980,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the long terminal repeat (LTR) of a Ty1 element
chrXV	301046	301238	301046	301238	+	YOL013W-A	YOL013W-A		301046,	301238,	Putative protein of unknown function  identified by SAGE
chrXV	301379	303035	301379	303035	-	HRD1	YOL013C		301379,	303035,	Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins  genetically linked to the unfolded protein response (UPR)  regulated through association with Hrd3p  contains an H2 ring finger
chrXV	303578	303983	303578	303983	-	HTZ1	YOL012C		303578,	303983,	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex  involved in transcriptional regulation through prevention of the spread of silent heterochromatin
chrXV	305348	307409	305348	307409	+	PLB3	YOL011W		305348,	307409,	Phospholipase B (lysophospholipase) involved in phospholipid metabolism  hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
chrXV	307937	309041	307937	309041	+	RCL1	YOL010W		307937,	309041,	Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly  stimulates Bms1p GTPase and U3 binding activity  similar to RNA cyclase-like proteins but no activity detected
chrXV	309323	310139	309323	310139	-	MDM12	YOL009C		309323,	310139,	Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells  component of the ERMES complex that links the ER to mitochondria  may influence import and assembly of outer membrane beta-barrel proteins
chrXV	310311	310935	310311	310935	+	COQ10	YOL008W		310311,	310935,	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration  START domain protein with homologs in bacteria and eukaryotes
chrXV	311341	312367	311341	312367	-	CSI2	YOL007C		311341,	312367,	Protein of unknown function  green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole  YOL007C is not an essential gene
chrXV	313077	315387	313077	315387	-	TOP1	YOL006C		313077,	315387,	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone  relaxes both positively and negatively supercoiled DNA  functions in replication, transcription, and recombination
chrXV	315812	316175	315812	316175	-	RPB11	YOL005C		315812,	316175,	RNA polymerase II subunit B12.5  part of central core  similar to Rpc19p and bacterial alpha subunit
chrXV	316937	321548	316937	321548	+	SIN3	YOL004W		316937,	321548,	Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis  involved in the maintenance of chromosomal integrity
chrXV	321857	322994	321857	322994	-	PFA4	YOL003C		321857,	322994,	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site  required for modification of Chs3p  member of the DHHC family of putative palmitoyltransferases
chrXV	323410	324364	323410	324364	-	IZH2	YOL002C		323410,	324364,	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis  transcription regulated by Zap1p, zinc and fatty acid levels  similar to mammalian adiponectins  deletion increases sensitivity to elevated zinc
chrXV	325248	326130	325248	326130	+	PHO80	YOL001W		325248,	326130,	Cyclin, interacts with cyclin-dependent kinase Pho85p  regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
chrXV	326831	329033	326831	329033	+	RRP6	YOR001W		326831,	329033,	Nuclear exosome exonuclease component  has 3'-5' exonuclease activity  involved in RNA processing, maturation, surveillance, degradation, tethering, and export  has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10)  mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
chrXV	329416	331051	329416	331051	+	ALG6	YOR002W		329416,	331051,	Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation  mutations in human ortholog are associated with disease
chrXV	331454	332891	331454	332891	+	YSP3	YOR003W		331454,	332891,	Putative precursor to the subtilisin-like protease III
chrXV	333591	334356	333591	334356	+	UTP23	YOR004W		333591,	334356,	Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis  has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
chrXV	334508	337343	334508	337343	-	DNL4	YOR005C		334508,	337343,	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p  involved in meiosis, not essential for vegetative growth
chrXV	337679	338621	337679	338621	-	TSR3	YOR006C		337679,	338621,	Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrXV	338937	339978	338937	339978	-	SGT2	YOR007C		338937,	339978,	Glutamine-rich cytoplasmic protein that serves as a scaffold for binding Get4/5p and other proteins required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane  has similarity to human cochaperone SGT
chrXV	341277	342414	341277	342414	-	SLG1	YOR008C		341277,	342414,	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway  involved in maintenance of cell wall integrity  required for mitophagy  involved in organization of the actin cytoskeleton  secretory pathway Wsc1p is required for the arrest of secretion response
chrXV	342856	343081	342856	343081	-	YOR008C-A	YOR008C-A		342856,	343081,	Putative protein of unknown function, includes a potential transmembrane domain  deletion results in slightly lengthened telomeres
chrXV	343928	344030	343928	344030	+	YOR008W-B	YOR008W-B		343928,	344030,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXV	344334	345798	344334	345798	+	TIR4	YOR009W		344334,	345798,	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins  expressed under anaerobic conditions and required for anaerobic growth  transcription is also induced by cold shock
chrXV	346194	346950	346194	346950	-	TIR2	YOR010C		346194,	346950,	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins  transcription is induced by cold shock and anaerobiosis
chrXV	349678	353863	349678	353863	+	AUS1	YOR011W		349678,	353863,	Plasma membrane sterol transporter of the ATP-binding cassette family  required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane  activity is stimulated by phosphatidylserine  sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
chrXV	355651	355858	355651	355858	+	YOR011W-A	YOR011W-A		355651,	355858,	Putative protein of unknown function
chrXV	356542	356956	356542	356956	+	YOR012W	YOR012W		356542,	356956,	Putative protein of unknown function
chrXV	356750	357221	356750	357221	+	IRC11	YOR013W		356750,	357221,	Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized gene YOR012C  null mutant displays increased levels of spontaneous Rad52 foci
chrXV	357673	359947	357673	359947	+	RTS1	YOR014W		357673,	359947,	B-type regulatory subunit of protein phosphatase 2A (PP2A)  Rts1p and Cdc55p are alternative regulatory subunits for PP2A  PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere  highly enriched at centromeres in absence of Cdc55p  homolog of the mammalian B' subunit of PP2A
chrXV	359992	360352	359992	360352	+	YOR015W	YOR015W		359992,	360352,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	360460	361084	360460	361084	-	ERP4	YOR016C		360460,	361084,	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
chrXV	361411	363814	361411	363814	+	PET127	YOR017W		361411,	363814,	Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane
chrXV	364368	366882	364368	366882	+	ROD1	YOR018W		364368,	366882,	Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs  overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium  proposed to regulate the endocytosis of plasma membrane proteins
chrXV	368126	370319	368126	370319	+	YOR019W	YOR019W		368126,	370319,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
chrXV	370523	370844	370523	370844	-	HSP10	YOR020C		370523,	370844,	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin  involved in protein folding and sorting in the mitochondria  10 kD heat shock protein with similarity to E. coli groES
chrXV	371684	371957	371684	371957	+	YOR020W-A	YOR020W-A		371684,	371957,	Putative protein of unknown function, conserved in A. gossypii  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXV	372797	373439	372797	373439	-	YOR021C	YOR021C		372797,	373439,	Putative protein of unknown function  YOR021C is not an essential gene  predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
chrXV	373709	375857	373709	375857	-	YOR022C	YOR022C		373709,	375857,	Protein with similarity to bovine phospholipase A1  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXV	376011	377712	376011	377712	-	AHC1	YOR023C		376011,	377712,	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
chrXV	377846	378170	377846	378170	+	YOR024W	YOR024W		377846,	378170,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXV	378218	379562	378218	379562	+	HST3	YOR025W		378218,	379562,	Member of the Sir2 family of NAD(+)-dependent protein deacetylases  involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
chrXV	379780	380806	379780	380806	+	BUB3	YOR026W		379780,	380806,	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores  forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
chrXV	381052	382822	381052	382822	+	STI1	YOR027W		381052,	382822,	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity  interacts with Hsp90 chaperones and inhibits their ATPase activity  homolog of mammalian Hop
chrXV	383532	384420	383532	384420	-	CIN5	YOR028C		383532,	384420,	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family  physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets  mediates pleiotropic drug resistance and salt tolerance  nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions
chrXV	384599	384935	384599	384935	+	YOR029W	YOR029W		384599,	384935,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	386824	388684	386824	388684	+	DFG16	YOR030W		386824,	388684,	Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation  required for accumulation of processed Rim101p
chrXV	389212	389422	389212	389422	+	CRS5	YOR031W		389212,	389422,	Copper-binding metallothionein, required for wild-type copper resistance
chrXV	389770	391075	389770	391075	-	HMS1	YOR032C		389770,	391075,	Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors  overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
chrXV	392175	392376	392175	392376	+	YOR032W-A	YOR032W-A		392175,	392376,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	392415	394524	392415	394524	-	EXO1	YOR033C		392415,	394524,	5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair  member of the Rad2p nuclease family, with conserved N and I nuclease domains
chrXV	394836	397086	394836	397086	-	AKR2	YOR034C		394836,	397086,	Ankyrin repeat-containing protein similar to Akr1p  member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain  possibly involved in constitutive endocytosis of Ste3p
chrXV	397425	397668	397425	397668	-	YOR034C-A	YOR034C-A		397425,	397668,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXV	397734	400104	397734	400104	-	SHE4	YOR035C		397734,	400104,	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function  involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
chrXV	400347	401214	400347	401214	+	PEP12	YOR036W		400347,	401214,	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole  controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment  syntaxin
chrXV	401554	402655	401554	402655	+	CYC2	YOR037W		401554,	402655,	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space  exhibits redox activity in vitro  likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
chrXV	402760	405388	402760	405388	-	HIR2	YOR038C		402760,	405388,	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription  recruits Swi-Snf complexes to histone gene promoters  promotes heterochromatic gene silencing with Asf1p
chrXV	405767	406544	405767	406544	+	CKB2	YOR039W		405767,	406544,	Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation  CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
chrXV	407063	407921	407063	407921	+	GLO4	YOR040W		407063,	407921,	Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
chrXV	408357	408789	408357	408789	-	YOR041C	YOR041C		408357,	408789,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  85% of ORF overlaps the uncharacterized gene CUE5  deletion in cyr1 mutant results in loss of stress resistance
chrXV	408424	409660	408424	409660	+	CUE5	YOR042W		408424,	409660,	Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrXV	410869	412330	410869	412330	+	WHI2	YOR043W		410869,	412330,	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation  regulates growth during the diauxic shift  negative regulator of G1 cyclin expression
chrXV	413006	413480	413006	413480	+	IRC23	YOR044W		413006,	413480,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion localizes to the ER  null mutant displays increased levels of spontaneous Rad52p foci
chrXV	413851	414037	413851	414037	+	TOM6	YOR045W		413851,	414037,	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins  promotes assembly and stability of the TOM complex
chrXV	414458	415907	414458	415907	-	DBP5	YOR046C		414458,	415907,	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family  involved in mRNA export from the nucleus  involved in translation termination  ATP/ADP cycling is regulated by Gle1p and Nup159p
chrXV	416346	417681	416346	417681	-	STD1	YOR047C		416346,	417681,	Protein involved in control of glucose-regulated gene expression  interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p  regulator of transcription factor Rgt1p  interactions with Pma1p appear to propagate [GAR+]
chrXV	418629	421650	418629	421650	-	RAT1	YOR048C		418629,	421650,	Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
chrXV	422667	423732	422667	423732	-	RSB1	YOR049C		422667,	423732,	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation  putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
chrXV	424269	424617	424269	424617	-	YOR050C	YOR050C		424269,	424617,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  null mutation is viable
chrXV	424845	426084	424845	426084	-	ETT1	YOR051C		424845,	426084,	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts  deletion increases stop codon readthrough
chrXV	426771	427224	426771	427224	-	YOR052C	YOR052C		426771,	427224,	Nuclear protein of unknown function  expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid  transcriptionally regulated by Rpn4p along with proteasome subunit genes  putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic
chrXV	427816	428158	427816	428158	+	YOR053W	YOR053W		427816,	428158,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene VHS3/YOR054C
chrXV	427832	429857	427832	429857	-	VHS3	YOR054C		427832,	429857,	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC  Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
chrXV	429477	429912	429477	429912	+	YOR055W	YOR055W		429477,	429912,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	430246	431626	430246	431626	-	NOB1	YOR056C		430246,	431626,	Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits  required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA
chrXV	432185	433373	432185	433373	+	SGT1	YOR057W		432185,	433373,	Cochaperone protein  regulates activity of adenylyl cyclase Cyr1p  involved in kinetochore complex assembly  associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex  acts as a linker between Skp1p and HSP90 complexes
chrXV	433687	436345	433687	436345	-	ASE1	YOR058C		433687,	436345,	Mitotic spindle midzone localized microtubule-associated protein (MAP) family member  required for spindle elongation and stabilization  undergoes cell cycle-regulated degradation by anaphase promoting complex  potential Cdc28p substrate
chrXV	438905	440258	438905	440258	-	YOR059C	YOR059C		438905,	440258,	Lipid particle protein of unknown function  contains a putative lipase serine active site  induced by transcription factor RPN4
chrXV	440389	441163	440389	441163	-	YOR060C	YOR060C		440389,	441163,	Protein with a role in chromosomal DNA replication  interacts with Sld3p and reduces its affinity for Cdc45p  deletion mutant has aberrant mitochondria
chrXV	441533	442553	441533	442553	+	CKA2	YOR061W		441533,	442553,	Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation  CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
chrXV	442724	443531	442724	443531	-	YOR062C	YOR062C		442724,	443531,	Protein of unknown function  similar to YKR075Cp and Reg1p  expression regulated by glucose and Rgt1p  GFP-fusion protein is induced in response to the DNA-damaging agent MMS
chrXV	444685	445849	444685	445849	+	RPL3	YOR063W		444685,	445849,	Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins  involved in the replication and maintenance of killer double stranded RNA virus
chrXV	446078	446738	446078	446738	-	YNG1	YOR064C		446078,	446738,	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3  contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
chrXV	447438	448368	447438	448368	+	CYT1	YOR065W		447438,	448368,	Cytochrome c1, component of the mitochondrial respiratory chain  expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
chrXV	449435	451325	449435	451325	+	MSA1	YOR066W		449435,	451325,	Activator of G1-specific transcription factors, MBF and SBF  involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation  localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
chrXV	451728	453462	451728	453462	-	ALG8	YOR067C		451728,	453462,	Glucosyl transferase, involved in N-linked glycosylation  adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis  similar to Alg6p
chrXV	453767	455795	453767	455795	+	VPS5	YOR069W		453767,	455795,	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus  structural component of the retromer membrane coat complex  forms a retromer subcomplex with Vps17p
chrXV	453868	454213	453868	454213	-	VAM10	YOR068C		453868,	454213,	Protein involved in vacuole morphogenesis  acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
chrXV	455906	457820	455906	457820	-	GYP1	YOR070C		455906,	457820,	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro)  involved in vesicle docking and fusion
chrXV	459479	461276	459479	461276	-	NRT1	YOR071C		459479,	461276,	High-affinity nicotinamide riboside transporter  also transports thiamine with low affinity  shares sequence similarity with Thi7p and Thi72p  proposed to be involved in 5-fluorocytosine sensitivity
chrXV	461501	461816	461501	461816	+	YOR072W	YOR072W		461501,	461816,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the dubious gene YOR072W-A  diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
chrXV	461790	462039	461790	462039	+	YOR072W-A	YOR072W-A		461790,	462039,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YOR072W  originally identified by fungal homology and RT-PCR
chrXV	464468	464630	464468	464630	+	YOR072W-B	YOR072W-B		464468,	464630,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXV	464770	466543	464770	466543	+	SGO1	YOR073W		464770,	466543,	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes  protects centromeric Rec8p at meiosis I  required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
chrXV	466674	467589	466674	467589	-	CDC21	YOR074C		466674,	467589,	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides  expression is induced at G1/S
chrXV	467389	467623	467389	467623	+	YOR073W-A	YOR073W-A		467389,	467623,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially/completely overlaps the verified ORF CDC21/YOR074C  identified by RT-PCR
chrXV	468211	469252	468211	469252	+	UFE1	YOR075W		468211,	469252,	t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion  forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
chrXV	469376	471620	469376	471620	-	SKI7	YOR076C		469376,	471620,	Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation  eRF3-like domain targets nonstop mRNA for degradation  null mutants have superkiller phenotype
chrXV	471898	472597	471898	472597	+	RTS2	YOR077W		471898,	472597,	Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
chrXV	472724	473369	472724	473369	+	BUD21	YOR078W		472724,	473369,	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA  originally isolated as bud-site selection mutant that displays a random budding pattern
chrXV	473474	474416	473474	474416	-	ATX2	YOR079C		473474,	474416,	Golgi membrane protein involved in manganese homeostasis  overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
chrXV	474593	476792	474593	476792	+	DIA2	YOR080W		474593,	476792,	Origin-binding F-box protein  forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p  plays a role in DNA replication  plays a role in transcription  required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning  involved in invasive and pseudohyphal growth
chrXV	476938	479188	476938	479188	-	TGL5	YOR081C		476938,	479188,	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity  involved in triacylglycerol mobilization  localizes to lipid particles  potential Cdc28p substrate
chrXV	479295	479637	479295	479637	-	YOR082C	YOR082C		479295,	479637,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the verified gene YOR083W
chrXV	479532	480420	479532	480420	+	WHI5	YOR083W		479532,	480420,	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1  phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5  periodically expressed in G1
chrXV	480586	481750	480586	481750	+	LPX1	YOR084W		480586,	481750,	Oleic acid-inducible, peroxisomal matrix localized lipase  transcriptionally activated by Yrm1p along with genes involved in multidrug resistance  peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
chrXV	482032	483085	482032	483085	+	OST3	YOR085W		482032,	483085,	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins  Ost3p is important for N-glycosylation of a subset of proteins
chrXV	483218	486779	483218	486779	-	TCB1	YOR086C		483218,	486779,	Lipid-binding protein containing three calcium and lipid binding domains  non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery  C-termini of Tcb1p, Tcb2p and Tcb3p interact
chrXV	487706	489734	487706	489734	+	YVC1	YOR087W		487706,	489734,	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
chrXV	490195	490828	490195	490828	-	VPS21	YOR089C		490195,	490828,	Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases  localized in endocytic intermediates  detected in mitochondria  geranylgeranylation required for membrane association  mammalian Rab5 homolog
chrXV	491122	492841	491122	492841	-	PTC5	YOR090C		491122,	492841,	Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit  acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
chrXV	493432	494470	493432	494470	+	TMA46	YOR091W		493432,	494470,	Protein of unknown function that associates with translating ribosomes  interacts with GTPase Rbg1p
chrXV	495126	496968	495126	496968	+	ECM3	YOR092W		495126,	496968,	Non-essential protein of unknown function  involved in signal transduction and the genotoxic response  induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
chrXV	497505	502452	497505	502452	-	YOR093C	YOR093C		497505,	502452,	Putative protein of unknown function  deletion causes sensitivity to unfolded protein response-inducing agents
chrXV	502794	503346	502794	503346	+	ARF3	YOR094W		502794,	503346,	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity  also has mRNA binding activity
chrXV	503551	504328	503551	504328	-	RKI1	YOR095C		503551,	504328,	Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway  participates in pyridoxine biosynthesis
chrXV	505793	506767	505793	506767	+	RPS7A	YOR096W		505793,506338,	505937,506767,	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp  interacts with Kti11p  deletion causes hypersensitivity to zymocin  has similarity to rat S7 and Xenopus S8 ribosomal proteins
chrXV	506977	507505	506977	507505	-	YOR097C	YOR097C		506977,	507505,	Putative protein of unknown function  identified as interacting with Hsp82p in a high-throughput two-hybrid screen  YOR097C is not an essential gene
chrXV	507947	511178	507947	511178	-	NUP1	YOR098C		507947,	511178,	Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC  potential Cdc28p substrate
chrXV	511824	513006	511824	513006	+	KTR1	YOR099W		511824,	513006,	Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation  type II membrane protein  member of the KRE2/MNT1 mannosyltransferase family
chrXV	513294	514278	513294	514278	-	CRC1	YOR100C		513294,	514278,	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
chrXV	515243	516173	515243	516173	+	RAS1	YOR101W		515243,	516173,	GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation  localized to the plasma membrane  homolog of mammalian RAS proto-oncogenes
chrXV	516422	516773	516422	516773	+	YOR102W	YOR102W		516422,	516773,	Dubious open reading frame, unlikely to encode a functional protein  extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex
chrXV	516448	516841	516448	516841	-	OST2	YOR103C		516448,	516841,	Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
chrXV	517641	518490	517641	518490	+	PIN2	YOR104W		517641,	518490,	Protein that induces appearance of [PIN+] prion when overproduced  predicted to be palmitoylated
chrXV	518194	518521	518194	518521	+	YOR105W	YOR105W		518194,	518521,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	519120	519972	519120	519972	+	VAM3	YOR106W		519120,	519972,	Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking  mediates docking/fusion of late transport intermediates with the vacuole  has an acidic di-leucine sorting signal and C-terminal transmembrane region
chrXV	521352	522282	521352	522282	+	RGS2	YOR107W		521352,	522282,	Negative regulator of glucose-induced cAMP signaling  directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
chrXV	523026	524841	523026	524841	+	LEU9	YOR108W		523026,	524841,	Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway  the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
chrXV	524604	524814	524604	524814	-	YOR108C-A	YOR108C-A		524604,	524814,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	525277	528601	525277	528601	+	INP53	YOR109W		525277,	528601,	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols  involved in trans Golgi network-to-early endosome pathway  hyperosmotic stress causes translocation to actin patches  contains Sac1 and 5-ptase domains
chrXV	528940	530248	528940	530248	+	TFC7	YOR110W		528940,	530248,	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC)  part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes
chrXV	530428	531127	530428	531127	+	YOR111W	YOR111W		530428,	531127,	Putative protein of unknown function
chrXV	531507	533793	531507	533793	+	CEX1	YOR112W		531507,	533793,	Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway  interacts with nuclear pore component Nup116p  copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
chrXV	534074	536819	534074	536819	+	AZF1	YOR113W		534074,	536819,	Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose  genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
chrXV	537569	538454	537569	538454	+	YOR114W	YOR114W		537569,	538454,	Putative protein of unknown function  null mutant is viable
chrXV	538658	539465	538658	539465	-	TRS33	YOR115C		538658,	539465,	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion  involved in endoplasmic reticulum (ER) to Golgi membrane traffic
chrXV	539762	544145	539762	544145	-	RPO31	YOR116C		539762,	544145,	RNA polymerase III largest subunit C160, part of core enzyme  similar to bacterial beta-prime subunit and to RPA190 and RPO21
chrXV	545028	546333	545028	546333	+	RPT5	YOR117W		545028,	546333,	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates  recruited to the GAL1-10 promoter region upon induction of transcription  similar to human TBP1
chrXV	546856	548560	546856	548560	+	RTC5	YOR118W		546856,	548560,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  null mutation suppresses cdc13-1 temperature sensitivity
chrXV	548791	550246	548791	550246	-	RIO1	YOR119C		548791,	550246,	Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
chrXV	551113	552052	551113	552052	+	GCY1	YOR120W		551113,	552052,	Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism  also has mRNA binding activity  member of the aldo-keto reductase (AKR) family
chrXV	551797	552103	551797	552103	-	YOR121C	YOR121C		551797,	552103,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  open reading frame overlaps the verified gene GCY1/YOR120W
chrXV	552297	552887	552297	552887	-	PFY1	YOR122C		552297,552874,	552665,552887,	Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions  involved in cytoskeleton organization  required for normal timing of actin polymerization in response to thermal stress
chrXV	553175	554570	553175	554570	-	LEO1	YOR123C		553175,	554570,	Component of the Paf1 complex  which associates with RNA polymerase II and is involved in histone methylation  plays a role in regulating Ty1 transposition  involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
chrXV	554823	558642	554823	558642	-	UBP2	YOR124C		554823,	558642,	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins  interacts with Rsp5p and is required for MVB sorting of membrane proteins  can cleave polyubiquitin and has isopeptidase activity
chrXV	559029	559731	559029	559731	-	CAT5	YOR125C		559029,	559731,	Protein required for ubiquinone (Coenzyme Q) biosynthesis  localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes  required for gluconeogenic gene activation
chrXV	559960	560677	559960	560677	-	IAH1	YOR126C		559960,	560677,	Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
chrXV	561169	564193	561169	564193	+	RGA1	YOR127W		561169,	564193,	GTPase-activating protein for the polarity-establishment protein Cdc42p  implicated in control of septin organization, pheromone response, and haploid invasive growth
chrXV	564475	566191	564475	566191	-	ADE2	YOR128C		564475,	566191,	Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway  red pigment accumulates in mutant cells deprived of adenine
chrXV	566876	569558	566876	569558	-	AFI1	YOR129C		566876,	569558,	Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p  participates in polarity development and maintenance of a normal haploid budding pattern  interacts with Cnm7p
chrXV	569928	570807	569928	570807	-	ORT1	YOR130C		569928,	570807,	Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis  human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
chrXV	572181	572838	572181	572838	-	YOR131C	YOR131C		572181,	572838,	Putative protein of unknown function  non-essential gene  overexpression causes a cell cycle delay or arrest
chrXV	573174	574830	573174	574830	+	VPS17	YOR132W		573174,	574830,	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport  peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation
chrXV	575097	577626	575097	577626	+	EFT1	YOR133W		575097,	577626,	Elongation factor 2 (EF-2), also encoded by EFT2  catalyzes ribosomal translocation during protein synthesis  contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
chrXV	578563	579793	578563	579793	+	BAG7	YOR134W		578563,	579793,	Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis  structurally and functionally related to Sac7p
chrXV	580158	580500	580158	580500	-	IRC14	YOR135C		580158,	580500,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YOR136W  null mutant displays increased levels of spontaneous Rad52 foci
chrXV	580249	581359	580249	581359	+	IDH2	YOR136W		580249,	581359,	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle  phosphorylated
chrXV	581812	583681	581812	583681	-	SIA1	YOR137C		581812,	583681,	Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
chrXV	584308	586324	584308	586324	-	RUP1	YOR138C		584308,	586324,	Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase  has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p  contains an UBA domain
chrXV	586949	587342	586949	587342	-	YOR139C	YOR139C		586949,	587342,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF SFL1/YOR140W
chrXV	586980	589281	586980	589281	+	SFL1	YOR140W		586980,	589281,	Transcriptional repressor and activator  involved in repression of flocculation-related genes, and activation of stress responsive genes  negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
chrXV	589941	592587	589941	592587	-	ARP8	YOR141C		589941,	592587,	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes  has mRNA binding activity
chrXV	593056	594046	593056	594046	+	LSC1	YOR142W		593056,	594046,	Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate  phosphorylated
chrXV	595111	600380	595111	600380	+	YOR142W-B	YOR142W-B		595111,596417,	596416,600380,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXV	595111	596434	595111	596434	+	YOR142W-A	YOR142W-A		595111,	596434,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXV	601382	602342	601382	602342	-	THI80	YOR143C		601382,	602342,	Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
chrXV	602716	605092	602716	605092	-	ELG1	YOR144C		602716,	605092,	Subunit of an alternative replication factor C complex important for DNA replication and genome integrity  suppresses spontaneous DNA damage  involved in homologous recombination-mediated repair and telomere homeostasis
chrXV	605346	606171	605346	606171	-	PNO1	YOR145C		605346,	606171,	Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis  contains a KH domain
chrXV	605872	606178	605872	606178	+	YOR146W	YOR146W		605872,	606178,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  open reading frame overlaps the verified gene PNO1/YOR145C
chrXV	606606	608475	606606	608475	+	MDM32	YOR147W		606606,	608475,	Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance  interacts genetically with MMM1, MDM10, MDM12, and MDM34
chrXV	608639	609197	608639	609197	-	SPP2	YOR148C		608639,	609197,	Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation  interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
chrXV	609837	611388	609837	611388	-	SMP3	YOR149C		609837,	611388,	Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis  required for addition of the fourth, side branching mannose to the GPI core structure
chrXV	611998	612490	611998	612490	+	MRPL23	YOR150W		611998,	612490,	Mitochondrial ribosomal protein of the large subunit
chrXV	612996	616671	612996	616671	-	RPB2	YOR151C		612996,	616671,	RNA polymerase II second largest subunit B150, part of central core  similar to bacterial beta subunit
chrXV	617517	618288	617517	618288	-	YOR152C	YOR152C		617517,	618288,	Putative protein of unknown function  YOR152C is not an essential gene
chrXV	619839	624375	619839	624375	+	PDR5	YOR153W		619839,	624375,	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p  also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
chrXV	624728	626492	624728	626492	+	SLP1	YOR154W		624728,	626492,	Integral membrane protein of unknown function  member of the SUN-like family of proteins  genetic interactions suggest a role in folding of ER membrane proteins
chrXV	626627	627980	626627	627980	-	ISN1	YOR155C		626627,	627980,	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
chrXV	628359	630540	628359	630540	-	NFI1	YOR156C		628359,	630540,	SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins  primary E3 ligase for Sir4p  sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring  promotes telomere anchoring to the nuclear envelope  involved in maintenance of proper telomere length
chrXV	630965	631751	630965	631751	-	PUP1	YOR157C		630965,	631751,	Beta 2 subunit of the 20S proteasome  endopeptidase with trypsin-like activity that cleaves after basic residues  synthesized as a proprotein before being proteolytically processed for assembly into 20S particle  human homolog is subunit Z
chrXV	632163	633120	632163	633120	+	PET123	YOR158W		632163,	633120,	Mitochondrial ribosomal protein of the small subunit  PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
chrXV	633281	633566	633281	633566	-	SME1	YOR159C		633281,	633566,	Core Sm protein Sm E  part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs  homolog of human Sm E
chrXV	633838	636757	633838	636757	+	MTR10	YOR160W		633838,	636757,	Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export  promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p  required for retrograde import of mature tRNAs
chrXV	636938	638558	636938	638558	-	PNS1	YOR161C		636938,	638558,	Protein of unknown function  has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
chrXV	637573	637654	637573	637654	+	YOR161W-A	YOR161W-A		637573,	637654,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	637974	638235	637974	638235	+	YOR161W-B	YOR161W-B		637974,	638235,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	639120	639267	639120	639267	-	YOR161C-C	YOR161C-C		639120,	639267,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	639559	641992	639559	641992	-	YRR1	YOR162C		639559,	641992,	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance  paralog of Yrm1p, acting on an overlapping set of target genes
chrXV	642740	643307	642740	643307	+	DDP1	YOR163W		642740,	643307,	Polyphosphate phosphatase  hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates  has high specificity for diadenosine hexa- and pentaphosphates  exhibits endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs  member of the MutT family of nucleotide hydrolases
chrXV	643393	644332	643393	644332	-	GET4	YOR164C		643393,	644332,	Protein with a role in insertion of tail-anchored proteins into the ER membrane  forms a complex with Mdy2p  highly conserved across species and homologous to human gene C7orf20
chrXV	644565	646896	644565	646896	+	SEY1	YOR165W		644565,	646896,	GTPase with a role in ER morphology  interacts physically and genetically with Yop1p and Rtn1p  possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia  homolog of Arabidopsis RHD3
chrXV	647125	648502	647125	648502	-	SWT1	YOR166C		647125,	648502,	RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs  interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II  contains a PIN (PilT N terminus) domain
chrXV	648803	649007	648803	649007	-	RPS28A	YOR167C		648803,	649007,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein
chrXV	649302	651732	649302	651732	+	GLN4	YOR168W		649302,	651732,	Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu)  N-terminal domain proposed to be involved in enzyme-tRNA interactions
chrXV	651375	651840	651375	651840	-	YOR169C	YOR169C		651375,	651840,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  open reading frame overlaps the verified gene GLN4/YOR168W
chrXV	651857	652163	651857	652163	+	YOR170W	YOR170W		651857,	652163,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene LCB4
chrXV	652009	653884	652009	653884	-	LCB4	YOR171C		652009,	653884,	Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
chrXV	654209	656570	654209	656570	+	YRM1	YOR172W		654209,	656570,	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance  paralog of Yrr1p, acting on an overlapping set of target genes
chrXV	657263	658325	657263	658325	+	DCS2	YOR173W		657263,	658325,	Non-essential, stress induced regulatory protein  modulates m7G-oligoribonucleotide metabolism  inhibits Dcs1p  regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway  mutant has increased aneuploidy tolerance
chrXV	658746	659601	658746	659601	+	MED4	YOR174W		658746,	659601,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation
chrXV	659814	661674	659814	661674	-	ALE1	YOR175C		659814,	661674,	Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases  key component of Lands cycle  may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
chrXV	662400	663582	662400	663582	+	HEM15	YOR176W		662400,	663582,	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
chrXV	665784	667179	665784	667179	-	MPC54	YOR177C		665784,	667179,	Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane  potential Cdc28p substrate
chrXV	667859	670241	667859	670241	-	GAC1	YOR178C		667859,	670241,	Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
chrXV	671844	672411	671844	672411	-	SYC1	YOR179C		671844,	672411,	Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
chrXV	674351	675167	674351	675167	-	DCI1	YOR180C		674351,	675167,	Peroxisomal protein  identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed
chrXV	675938	677840	675938	677840	+	LAS17	YOR181W		675938,	677840,	Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments  localizes with the Arp2/3 complex to actin patches  homolog of the human Wiskott-Aldrich syndrome protein (WASP)
chrXV	678190	678793	678190	678793	-	RPS30B	YOR182C		678190,678790,	678379,678793,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein
chrXV	678871	679261	678871	679261	+	FYV12	YOR183W		678871,	679261,	Protein of unknown function, required for survival upon exposure to K1 killer toxin
chrXV	679356	680544	679356	680544	+	SER1	YOR184W		679356,	680544,	3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis  regulated by the general control of amino acid biosynthesis mediated by Gcn4p
chrXV	681443	682106	681443	682106	-	GSP2	YOR185C		681443,	682106,	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport  interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas)  Gsp1p homolog that is not required for viability
chrXV	683110	683545	683110	683545	+	YOR186W	YOR186W		683110,	683545,	Putative protein of unknown function  proper regulation of expression during heat stress is sphingolipid-dependent
chrXV	683328	683538	683328	683538	-	YOR186C-A	YOR186C-A		683328,	683538,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	684029	685343	684029	685343	+	TUF1	YOR187W		684029,	685343,	Mitochondrial translation elongation factor Tu  comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
chrXV	685766	689180	685766	689180	+	MSB1	YOR188W		685766,	689180,	Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate  multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4
chrXV	689623	689974	689623	689974	+	IES4	YOR189W		689623,	689974,	Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway  proposed to link chromatin remodeling to replication checkpoint responses
chrXV	690694	692032	690694	692032	+	SPR1	YOR190W		690694,	692032,	Sporulation-specific exo-1,3-beta-glucanase  contributes to ascospore thermoresistance
chrXV	692474	697334	692474	697334	+	ULS1	YOR191W		692474,	697334,	RING finger protein involved in proteolytic control of sumoylated substrates  interacts with SUMO (Smt3p)  member of the SWI/SNF family of DNA-dependent ATPases  plays a role in antagonizing silencing during mating-type switching
chrXV	698767	700567	698767	700567	-	THI72	YOR192C		698767,	700567,	Transporter of thiamine or related compound  shares sequence similarity with Thi7p
chrXV	703987	704224	703987	704224	-	YOR192C-C	YOR192C-C		703987,	704224,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXV	704418	709732	704418	709732	-	YOR192C-B	YOR192C-B		704418,708439,	708438,709732,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXV	708415	709732	708415	709732	-	YOR192C-A	YOR192C-A		708415,	709732,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXV	710445	711576	710445	711576	+	PEX27	YOR193W		710445,	711576,	Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
chrXV	711682	712543	711682	712543	-	TOA1	YOR194C		711682,	712543,	TFIIA large subunit  involved in transcriptional activation, acts as antirepressor or as coactivator  homologous to largest and second largest subunits of human and Drosophila TFIIA
chrXV	712865	715331	712865	715331	+	SLK19	YOR195W		712865,	715331,	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis  component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase  potential Cdc28p substrate
chrXV	715592	716837	715592	716837	-	LIP5	YOR196C		715592,	716837,	Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
chrXV	717085	718384	717085	718384	+	MCA1	YOR197W		717085,	718384,	Putative cysteine protease similar to mammalian caspases  involved in regulation of apoptosis upon H2O2 treatment  contributes to clearance of insoluble protein aggregates during normal growth  may be involved in cell cycle progression
chrXV	718652	720065	718652	720065	-	BFR1	YOR198C		718652,	720065,	Component of mRNP complexes associated with polyribosomes  implicated in secretion and nuclear segregation  multicopy suppressor of BFA (Brefeldin A) sensitivity
chrXV	720180	720510	720180	720510	+	YOR199W	YOR199W		720180,	720510,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXV	720416	720815	720416	720815	+	YOR200W	YOR200W		720416,	720815,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF MRM1/YOR201c
chrXV	720469	721708	720469	721708	-	MRM1	YOR201C		720469,	721708,	Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA
chrXV	721945	722608	721945	722608	+	HIS3	YOR202W		721945,	722608,	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis  mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts  transcription is regulated by general amino acid control via Gcn4p
chrXV	722564	722918	722564	722918	+	YOR203W	YOR203W		722564,	722918,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps 5' end of essential DED1 gene required for translation initiation
chrXV	722910	724725	722910	724725	+	DED1	YOR204W		722910,	724725,	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs  mutations in human DEAD-box DBY are a frequent cause of male infertility
chrXV	725563	727234	725563	727234	-	GEP3	YOR205C		725563,	727234,	Protein of unknown function  null mutant is defective in respiration and interacts synthetically with prohibitin (phb1)  the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
chrXV	727511	729644	727511	729644	+	NOC2	YOR206W		727511,	729644,	Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes  both complexes mediate intranuclear transport of ribosomal precursors
chrXV	730007	733457	730007	733457	-	RET1	YOR207C		730007,	733457,	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
chrXV	733924	736177	733924	736177	+	PTP2	YOR208W		733924,	736177,	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing  dephosporylates Hog1p MAPK and regulates its localization  localized to the nucleus
chrXV	736436	737726	736436	737726	-	NPT1	YOR209C		736436,	737726,	Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis  required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci  localized to the nucleus
chrXV	738319	738532	738319	738532	+	RPB10	YOR210W		738319,	738532,	RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
chrXV	738923	741569	738923	741569	-	MGM1	YOR211C		738923,	741569,	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p  required for mt morphology and genome maintenance  exists as long and short form with different distributions  homolog of human OPA1 involved in autosomal dominant optic atrophy
chrXV	742909	744181	742909	744181	+	STE4	YOR212W		742909,	744181,	G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling  may recruit Rho1p to the polarized growth site during mating  contains WD40 repeats
chrXV	744534	745281	744534	745281	-	SAS5	YOR213C		744534,	745281,	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing  stimulates Sas2p HAT activity
chrXV	745592	746303	745592	746303	-	YOR214C	YOR214C		745592,	746303,	Putative protein of unknown function  YOR214C is not an essential gene
chrXV	746724	747282	746724	747282	-	AIM41	YOR215C		746724,	747282,	Putative protein of unknown function  the authentic protein is detected in highly purified mitochondria in high-throughput studies  null mutant displays reduced frequency of mitochondrial genome loss
chrXV	747524	748979	747524	748979	-	RUD3	YOR216C		747524,	748979,	Golgi matrix protein involved in the structural organization of the cis-Golgi  interacts genetically with COG3 and USO1
chrXV	749300	751886	749300	751886	+	RFC1	YOR217W		749300,	751886,	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
chrXV	751475	751895	751475	751895	-	YOR218C	YOR218C		751475,	751895,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  open reading frame overlaps the verified gene RFC1/YOR217W
chrXV	752213	755009	752213	755009	-	STE13	YOR219C		752213,	755009,	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
chrXV	755327	756125	755327	756125	+	RCN2	YOR220W		755327,	756125,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS  phosphorylated in response to alpha factor
chrXV	756475	757558	756475	757558	-	MCT1	YOR221C		756475,	757558,	Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
chrXV	758329	759253	758329	759253	+	ODC2	YOR222W		758329,	759253,	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
chrXV	759781	760660	759781	760660	+	YOR223W	YOR223W		759781,	760660,	Protein of unknown function found in the ER and vacuole lumen  overexpression of YOR223W affects endocytic protein trafficking
chrXV	760824	761265	760824	761265	-	RPB8	YOR224C		760824,	761265,	RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
chrXV	761391	761721	761391	761721	+	YOR225W	YOR225W		761391,	761721,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	761613	762084	761613	762084	-	ISU2	YOR226C		761613,	762084,	Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly  isu1 isu2 double mutant is inviable
chrXV	762824	766565	762824	766565	+	HER1	YOR227W		762824,	766565,	Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p  may interact with ribosomes, based on co-purification experiments
chrXV	766868	767777	766868	767777	-	YOR228C	YOR228C		766868,	767777,	Protein of unknown function, localized to the mitochondrial outer membrane
chrXV	768408	769812	768408	769812	+	WTM2	YOR229W		768408,	769812,	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes  involved in response to replication stress  contains WD repeats
chrXV	770799	772113	770799	772113	+	WTM1	YOR230W		770799,	772113,	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes  required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p  contains WD repeats
chrXV	772600	774127	772600	774127	+	MKK1	YOR231W		772600,	774127,	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity  upon activation by Bck1p phosphorylates downstream target, Slt2p  functionally redundant with Mkk2p
chrXV	773162	773363	773162	773363	-	YOR231C-A	YOR231C-A		773162,	773363,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	774572	775259	774572	775259	+	MGE1	YOR232W		774572,	775259,	Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding  also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins  homolog of E. coli GrpE
chrXV	775845	778248	775845	778248	+	KIN4	YOR233W		775845,	778248,	Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated  localized asymmetrically to mother cell cortex, spindle pole body and bud neck
chrXV	778554	779405	778554	779405	-	RPL33B	YOR234C		778554,779386,	778859,779405,	Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a  rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
chrXV	779869	780184	779869	780184	+	IRC13	YOR235W		779869,	780184,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  null mutant displays increased levels of spontaneous Rad52 foci
chrXV	780905	781541	780905	781541	+	DFR1	YOR236W		780905,	781541,	Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
chrXV	781993	783298	781993	783298	+	HES1	YOR237W		781993,	783298,	Protein implicated in the regulation of ergosterol biosynthesis  one of a seven member gene family with a common essential function and non-essential unique functions  similar to human oxysterol binding protein (OSBP)
chrXV	783676	784588	783676	784588	+	YOR238W	YOR238W		783676,	784588,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXV	784856	786744	784856	786744	+	ABP140	YOR239W		784856,785688,	785687,786744,	AdoMet-dependent tRNA methyltransferase and actin binding protein  C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif  N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables  N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
chrXV	786994	788641	786994	788641	+	MET7	YOR241W		786994,	788641,	Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA
chrXV	788741	789857	788741	789857	-	SSP2	YOR242C		788741,	789857,	Sporulation specific protein that localizes to the spore wall  required for sporulation at a point after meiosis II and during spore wall formation  SSP2 expression is induced midway in meiosis
chrXV	790210	792241	790210	792241	-	PUS7	YOR243C		790210,	792241,	Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr)  conserved in archaea, vertebrates, and some bacteria
chrXV	792530	793868	792530	793868	+	ESA1	YOR244W		792530,	793868,	Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail  required for cell cycle progression and transcriptional silencing at the rDNA locus
chrXV	794075	795332	794075	795332	-	DGA1	YOR245C		794075,	795332,	Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
chrXV	795800	796793	795800	796793	-	YOR246C	YOR246C		795800,	796793,	Protein with similarity to oxidoreductases, found in lipid particles  required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
chrXV	797675	798308	797675	798308	+	SRL1	YOR247W		797675,	798308,	Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins  has a high serine-threonine content  expression is induced in cell wall mutants
chrXV	798012	798315	798012	798315	+	YOR248W	YOR248W		798012,	798315,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	798673	800731	798673	800731	-	APC5	YOR249C		798673,	800731,	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition  component of the platform domain of the APC/C, based on structural analysis
chrXV	800969	802307	800969	802307	-	CLP1	YOR250C		800969,	802307,	Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
chrXV	802549	803464	802549	803464	-	TUM1	YOR251C		802549,	803464,	Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs  also stimulates sulfur transfer by Nfs1p  may be mitochondrially localized
chrXV	803666	804203	803666	804203	+	TMA16	YOR252W		803666,	804203,	Protein of unknown function that associates with ribosomes
chrXV	804376	804907	804376	804907	+	NAT5	YOR253W		804376,	804907,	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p)  N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
chrXV	805031	807023	805031	807023	-	SEC63	YOR254C		805031,	807023,	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)  with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
chrXV	807270	808107	807270	808107	+	OSW1	YOR255W		807270,	808107,	Protein involved in sporulation  required for the construction of the outer spore wall layers  required for proper localization of Spo14p
chrXV	808253	810683	808253	810683	-	TRE2	YOR256C		808253,	810683,	Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p  has similarity to transferrin receptors  inviability of null mutant in systematic studies is due to proximity to CDC31
chrXV	811007	811493	811007	811493	+	CDC31	YOR257W		811007,	811493,	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II  homolog of mammalian centrin  binds multiubiquitinated proteins and is involved in proteasomal protein degradation
chrXV	811670	812324	811670	812324	+	HNT3	YOR258W		811670,	812324,	DNA 5' AMP hydrolase involved in DNA repair  member of the histidine triad (HIT) superfamily of nucleotide-binding proteins  homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia
chrXV	812394	813708	812394	813708	-	RPT4	YOR259C		812394,	813708,	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates  contributes preferentially to ERAD  required for spindle pole body duplication  mainly nuclear localization
chrXV	813983	815720	813983	815720	+	GCD1	YOR260W		813983,	815720,	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2  activity subsequently regulated by phosphorylated eIF2  first identified as a negative regulator of GCN4 expression
chrXV	815914	816931	815914	816931	-	RPN8	YOR261C		815914,	816931,	Essential, non-ATPase regulatory subunit of the 26S proteasome  has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
chrXV	817291	818335	817291	818335	+	YOR262W	YOR262W		817291,	818335,	Protein of unknown function required for establishment of sister chromatid cohesion  contains an ATP/GTP binding site motif  similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B
chrXV	818756	819164	818756	819164	-	YOR263C	YOR263C		818756,	819164,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF DES3/YOR264W
chrXV	818865	820158	818865	820158	+	DSE3	YOR264W		818865,	820158,	Daughter cell-specific protein, may help establish daughter fate
chrXV	820453	820774	820453	820774	+	RBL2	YOR265W		820453,	820774,	Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin  proposed to be involved the folding of beta-tubulin  similar to mouse beta-tubulin cofactor A
chrXV	821022	822294	821022	822294	+	PNT1	YOR266W		821022,	822294,	Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p  deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
chrXV	822587	824867	822587	824867	-	HRK1	YOR267C		822587,	824867,	Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism  plays a role in ion homeostasis
chrXV	825533	825932	825533	825932	-	YOR268C	YOR268C		825533,	825932,	Putative protein of unknown function  sporulation is abnormal in homozygous diploid  YOR268C is not an essential gene
chrXV	826384	827869	826384	827869	+	PAC1	YOR269W		826384,	827869,	Protein involved in nuclear migration, part of the dynein/dynactin pathway  targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex  synthetic lethal with bni1  homolog of human LIS1
chrXV	828051	830574	828051	830574	-	VPH1	YOR270C		828051,	830574,	Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p)  Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
chrXV	831058	832042	831058	832042	-	FSF1	YOR271C		831058,	832042,	Putative protein, predicted to be an alpha-isopropylmalate carrier  belongs to the sideroblastic-associated protein family  non-tagged protein is detected in purified mitochondria  likely to play a role in iron homeostasis
chrXV	832812	834195	832812	834195	+	YTM1	YOR272W		832812,	834195,	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit  has seven C-terminal WD repeats
chrXV	834451	836431	834451	836431	-	TPO4	YOR273C		834451,	836431,	Polyamine transport protein, recognizes spermine, putrescine, and spermidine  localizes to the plasma membrane  member of the major facilitator superfamily
chrXV	837673	838960	837673	838960	+	MOD5	YOR274W		837673,	838960,	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs  gene is nuclear and encodes two isozymic forms
chrXV	839083	841069	839083	841069	-	RIM20	YOR275C		839083,	841069,	Protein involved in proteolytic activation of Rim101p in response to alkaline pH  PalA/AIP1/Alix family member  interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
chrXV	841332	841818	841332	841818	+	CAF20	YOR276W		841332,	841818,	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
chrXV	841514	841823	841514	841823	-	YOR277C	YOR277C		841514,	841823,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  almost completely overlaps the verified gene CAF20
chrXV	842816	843644	842816	843644	+	HEM4	YOR278W		842816,	843644,	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis  deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
chrXV	843697	844630	843697	844630	-	RFM1	YOR279C		843697,	844630,	DNA-binding protein required for vegetative repression of middle sporulation genes  specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p  involved in telomere maintenance
chrXV	844991	845792	844991	845792	-	FSH3	YOR280C		844991,	845792,	Putative serine hydrolase  likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation  sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2
chrXV	846268	847129	846268	847129	-	PLP2	YOR281C		846268,	847129,	Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding  has similarity to phosducins  null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP
chrXV	846999	847320	846999	847320	+	YOR282W	YOR282W		846999,	847320,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps essential, verified gene PLP2/YOR281C
chrXV	847452	848145	847452	848145	+	YOR283W	YOR283W		847452,	848145,	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase  YOR283W is not an essential gene
chrXV	848477	849209	848477	849209	+	HUA2	YOR284W		848477,	849209,	Cytoplasmic protein of unknown function  computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
chrXV	849634	850054	849634	850054	+	RDL1	YOR285W		849634,	850054,	Protein of unknown function containing a rhodanese-like domain  localized to the mitochondrial outer membrane
chrXV	850279	850729	850279	850729	+	RDL2	YOR286W		850279,	850729,	Protein with rhodanese activity  contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p  overexpression causes a cell cycle delay  null mutant displays elevated frequency of mitochondrial genome loss
chrXV	850936	851839	850936	851839	-	RRP36	YOR287C		850936,	851839,	Component of 90S preribosomes  involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
chrXV	852120	853077	852120	853077	-	MPD1	YOR288C		852120,	853077,	Member of the protein disulfide isomerase (PDI) family  interacts with and inhibits the chaperone activity of Cne1p  MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
chrXV	853356	854112	853356	854112	+	YOR289W	YOR289W		853356,	854112,	Putative protein of unknown function  transcription induced by the unfolded protein response  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrXV	855146	860258	855146	860258	-	SNF2	YOR290C		855146,	860258,	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation  contains DNA-stimulated ATPase activity  functions interdependently in transcriptional activation with Snf5p and Snf6p
chrXV	861174	865593	861174	865593	+	YPK9	YOR291W		861174,	865593,	Vacuolar protein with a possible role in sequestering heavy metals  has similarity to the type V P-type ATPase Spf1p  homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
chrXV	865652	866582	865652	866582	-	YOR292C	YOR292C		865652,	866582,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the vacuole  YOR292C is not an essential gene
chrXV	867097	867852	867097	867852	+	RPS10A	YOR293W		867097,867586,	867149,867852,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
chrXV	867997	868147	867997	868147	-	YOR293C-A	YOR293C-A		867997,	868147,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXV	868339	868951	868339	868951	+	RRS1	YOR294W		868339,	868951,	Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis  mouse homolog shows altered expression in Huntington's disease model mice
chrXV	869207	869894	869207	869894	+	UAF30	YOR295W		869207,	869894,	Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4  deletion decreases cellular growth rate
chrXV	870201	874071	870201	874071	+	YOR296W	YOR296W		870201,	874071,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  expressed during copper starvation  YOR296W is not an essential gene
chrXV	874742	875321	874742	875321	-	TIM18	YOR297C		874742,	875321,	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane  may mediate assembly or stability of the complex
chrXV	875598	877038	875598	877038	+	MUM3	YOR298W		875598,	877038,	Protein of unknown function involved in the organization of the outer spore wall layers  has similarity to the tafazzins superfamily of acyltransferases
chrXV	877229	877685	877229	877685	-	MBF1	YOR298C-A		877229,	877685,	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p  suppressor of frameshift mutations
chrXV	878434	880675	878434	880675	+	BUD7	YOR299W		878434,	880675,	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
chrXV	880574	880883	880574	880883	+	YOR300W	YOR300W		880574,	880883,	Dubious open reading frame, unlikely to encode a protein  overlaps with verified gene BUD7/YOR299W  mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
chrXV	880964	882272	880964	882272	+	RAX1	YOR301W		880964,	882272,	Protein involved in bud site selection during bipolar budding  localization requires Rax2p  has similarity to members of the insulin-related peptide superfamily
chrXV	882764	882842	882764	882842	+	YOR302W	YOR302W		882764,	882842,	CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
chrXV	882898	884134	882898	884134	+	CPA1	YOR303W		882898,	884134,	Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor  translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
chrXV	884513	887876	884513	887876	+	ISW2	YOR304W		884513,	887876,	ATP-dependent DNA translocase involved in chromatin remodeling  ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
chrXV	888519	888750	888519	888750	-	YOR304C-A	YOR304C-A		888519,	888750,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
chrXV	889021	889750	889021	889750	+	RRG7	YOR305W		889021,	889750,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion  deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)  YOR305W is not an essential gene
chrXV	889866	891432	889866	891432	-	MCH5	YOR306C		889866,	891432,	Plasma membrane riboflavin transporter  facilitates the uptake of vitamin B2  required for FAD-dependent processes  sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
chrXV	892730	894092	892730	894092	-	SLY41	YOR307C		892730,	894092,	Protein involved in ER-to-Golgi transport
chrXV	894623	896387	894623	896387	-	SNU66	YOR308C		894623,	896387,	Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome  also required for pre-5S rRNA processing and may act in concert with Rnh70p  has homology to human SART-1
chrXV	896697	897078	896697	897078	-	YOR309C	YOR309C		896697,	897078,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene NOP58
chrXV	896824	898360	896824	898360	-	NOP58	YOR310C		896824,	898360,	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis  component of the small subunit processome complex, which is required for processing of pre-18S rRNA
chrXV	899055	899928	899055	899928	-	DGK1	YOR311C		899055,	899928,	Diacylglycerol kinase, localized to the endoplasmic reticulum (ER)  overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation  contains a CTP transferase domain
chrXV	900249	901194	900249	901194	-	RPL20B	YOR312C		900249,901193,	900767,901194,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
chrXV	901857	902874	901857	902874	-	SPS4	YOR313C		901857,	902874,	Protein whose expression is induced during sporulation  not required for sporulation  heterologous expression in E. coli induces the SOS response that senses DNA damage
chrXV	903042	903372	903042	903372	+	YOR314W	YOR314W		903042,	903372,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXV	904457	904568	904457	904568	+	YOR314W-A	YOR314W-A		904457,	904568,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXV	904759	905800	904759	905800	+	SFG1	YOR315W		904759,	905800,	Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth  may act together with Phd1p  potential Cdc28p substrate
chrXV	906235	907555	906235	907555	-	COT1	YOR316C		906235,	907555,	Vacuolar transporter that mediates zinc transport into the vacuole  overexpression confers resistance to cobalt and rhodium
chrXV	907725	907935	907725	907935	-	YOR316C-A	YOR316C-A		907725,	907935,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXV	909342	911445	909342	911445	+	FAA1	YOR317W		909342,	911445,	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths  functions in long chain fatty acid import  accounts for most acyl-CoA synthetase activity  localized to lipid particles
chrXV	911783	912436	911783	912436	-	YOR318C	YOR318C		911783,912432,	912085,912436,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
chrXV	912821	913463	912821	913463	+	HSH49	YOR319W		912821,	913463,	U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49  proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p  contains two RNA recognition motifs (RRM)
chrXV	913618	915094	913618	915094	-	GNT1	YOR320C		913618,	915094,	N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
chrXV	916029	918291	916029	918291	+	PMT3	YOR321W		916029,	918291,	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues  acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions  target for new antifungals
chrXV	918605	921062	918605	921062	-	LDB19	YOR322C		918605,	921062,	Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target  localization changes in response to nutrient levels  null mutant has reduced affinity for alcian blue dye
chrXV	921534	922905	921534	922905	-	PRO2	YOR323C		921534,	922905,	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
chrXV	923231	925040	923231	925040	-	FRT1	YOR324C		923231,	925040,	Tail-anchored ER membrane protein that is a substrate of the phosphatase calcineurin  interacts with homolog Frt2p  promotes cell growth in stress conditions, possibly via a role in posttranslational translocation
chrXV	924576	925050	924576	925050	+	YOR325W	YOR325W		924576,	925050,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF FRT1
chrXV	925720	930445	925720	930445	+	MYO2	YOR326W		925720,	930445,	One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos  required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
chrXV	930733	931081	930733	931081	-	SNC2	YOR327C		930733,	931081,	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane  member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
chrXV	931802	936497	931802	936497	+	PDR10	YOR328W		931802,	936497,	ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network  regulated by Pdr1p and Pdr3p
chrXV	936730	939349	936730	939349	-	SCD5	YOR329C		936730,	939349,	Protein required for normal actin organization and endocytosis  targeting subunit for protein phosphatase type 1  undergoes Crm1p-dependent nuclear-cytoplasmic shuttling  multicopy suppressor of clathrin deficiency
chrXV	939347	939557	939347	939557	+	YOR329W-A	YOR329W-A		939347,	939557,	Dubious open reading frame unlikely to encode a functional protein  identified by fungal homology and RT-PCR
chrXV	939620	943385	939620	943385	-	MIP1	YOR330C		939620,	943385,	Catalytic subunit of the mitochondrial DNA polymerase  conserved C-terminal segment is required for the maintenance of mitochondrial genome  related to human POLG, which has been associated with mitochondrial diseases
chrXV	943564	944122	943564	944122	-	YOR331C	YOR331C		943564,	944122,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  open reading frame overlaps the verified gene VMA4/YOR332W
chrXV	943655	944357	943655	944357	+	VMA4	YOR332W		943655,	944357,	Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system  required for the V1 domain to assemble onto the vacuolar membrane
chrXV	944540	944957	944540	944957	-	YOR333C	YOR333C		944540,	944957,	Dubious open reading frame, unlikely to encode a functional protein  overlaps 5' end of MRS2 gene required for respiratory growth
chrXV	944595	946008	944595	946008	+	MRS2	YOR334W		944595,	946008,	Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
chrXV	946232	949109	946232	949109	-	ALA1	YOR335C		946232,	949109,	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis  point mutation (cdc64-1 allele) causes cell cycle arrest at G1  lethality of null mutation is functionally complemented by human homolog
chrXV	946567	946648	946567	946648	+	YOR335W-A	YOR335W-A		946567,	946648,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene ALA1/YOR335C
chrXV	949772	953870	949772	953870	+	KRE5	YOR336W		949772,	953870,	Protein required for beta-1,6 glucan biosynthesis  mutations result in aberrant morphology and severe growth defects
chrXV	954343	956623	954343	956623	+	TEA1	YOR337W		954343,	956623,	Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription  C6 zinc cluster DNA-binding protein
chrXV	956897	957989	956897	957989	+	YOR338W	YOR338W		956897,	957989,	Putative protein of unknown function  YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p  identified as being required for sporulation in a high-throughput mutant screen
chrXV	958361	958832	958361	958832	-	UBC11	YOR339C		958361,	958832,	Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2  unlike E2-C, not required for the degradation of mitotic cyclin Clb2
chrXV	959201	960182	959201	960182	-	RPA43	YOR340C		959201,	960182,	RNA polymerase I subunit A43
chrXV	960986	965981	960986	965981	+	RPA190	YOR341W		960986,	965981,	RNA polymerase I largest subunit A190
chrXV	966665	967625	966665	967625	-	YOR342C	YOR342C		966665,	967625,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
chrXV	968147	968474	968147	968474	-	YOR343C	YOR343C		968147,	968474,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXV	970577	975891	970577	975891	+	YOR343W-B	YOR343W-B		970577,971872,	971871,975891,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXV	970577	971894	970577	971894	+	YOR343W-A	YOR343W-A		970577,	971894,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXV	977193	978069	977193	978069	-	TYE7	YOR344C		977193,	978069,	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif  binds E-boxes of glycolytic genes and contributes to their activation  may function as a transcriptional activator in Ty1-mediated gene expression
chrXV	981811	982162	981811	982162	-	YOR345C	YOR345C		981811,	982162,	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data  overlaps the verified gene REV1  null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
chrXV	981827	984785	981827	984785	+	REV1	YOR346W		981827,	984785,	Deoxycytidyl transferase  involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS)  forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p
chrXV	984941	986462	984941	986462	-	PYK2	YOR347C		984941,	986462,	Pyruvate kinase that appears to be modulated by phosphorylation  PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
chrXV	986898	988782	986898	988782	-	PUT4	YOR348C		986898,	988782,	Proline permease, required for high-affinity transport of proline  also transports the toxic proline analog azetidine-2-carboxylate (AzC)  PUT4 transcription is repressed in ammonia-grown cells
chrXV	989788	992833	989788	992833	+	CIN1	YOR349W		989788,	992833,	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding  isolated as mutant with increased chromosome loss and sensitivity to benomyl
chrXV	992863	994855	992863	994855	-	MNE1	YOR350C		992863,	994855,	Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
chrXV	995017	996511	995017	996511	-	MEK1	YOR351C		995017,	996511,	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
chrXV	997212	998244	997212	998244	+	YOR352W	YOR352W		997212,	998244,	Putative protein of unknown function  expression levels regulated by Arg5,6p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
chrXV	998452	1000828	998452	1000828	-	SOG2	YOR353C		998452,	1000828,	Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
chrXV	1001146	1003225	1001146	1003225	-	MSC6	YOR354C		1001146,	1003225,	Protein of unknown function  mutant is defective in directing meiotic recombination events to homologous chromatids  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXV	1005136	1006705	1005136	1006705	+	GDS1	YOR355W		1005136,	1006705,	Protein of unknown function, required for growth on glycerol as a carbon source  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXV	1007220	1009116	1007220	1009116	+	YOR356W	YOR356W		1007220,	1009116,	Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH)  found in a large supramolecular complex with other mitochondrial dehydrogenases  may have a role in oxidative stress response
chrXV	1009223	1009712	1009223	1009712	-	SNX3	YOR357C		1009223,	1009712,	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment  contains a PX domain and sequence similarity to human Snx3p
chrXV	1010160	1010889	1010160	1010889	+	HAP5	YOR358W		1010160,	1010889,	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression  required for assembly and DNA binding activity of the complex
chrXV	1011188	1012760	1011188	1012760	+	VTS1	YOR359W		1011188,	1012760,	Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein  shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic  stimulates Dna2p endonuclease activity  contains a SAM domain
chrXV	1013240	1014821	1013240	1014821	-	PDE2	YOR360C		1013240,	1014821,	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
chrXV	1015360	1017652	1015360	1017652	-	PRT1	YOR361C		1015360,	1017652,	eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation  part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
chrXV	1017879	1018746	1017879	1018746	-	PRE10	YOR362C		1017879,	1018746,	Alpha 7 subunit of the 20S proteasome
chrXV	1020221	1023212	1020221	1023212	-	PIP2	YOR363C		1020221,	1023212,	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes
chrXV	1023370	1023739	1023370	1023739	+	YOR364W	YOR364W		1023370,	1023739,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YOR365C
chrXV	1023460	1025572	1023460	1025572	-	YOR365C	YOR365C		1023460,	1025572,	Putative protein of unknown function  YOR365C is not an essential protein
chrXV	1025255	1025609	1025255	1025609	+	YOR366W	YOR366W		1025255,	1025609,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YOR365C
chrXV	1026006	1026609	1026006	1026609	+	SCP1	YOR367W		1026006,	1026609,	Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments  originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
chrXV	1026842	1028048	1026842	1028048	+	RAD17	YOR368W		1026842,	1028048,	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints  with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA  homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
chrXV	1028193	1028625	1028193	1028625	-	RPS12	YOR369C		1028193,	1028625,	Protein component of the small (40S) ribosomal subunit  has similarity to rat ribosomal protein S12
chrXV	1029182	1030994	1029182	1030994	-	MRS6	YOR370C		1029182,	1030994,	Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)  sequence similarity to mammalian choroideraemia gene
chrXV	1031488	1034182	1031488	1034182	-	GPB1	YOR371C		1031488,	1034182,	Multistep regulator of cAMP-PKA signaling  inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency  promotes ubiquitin-dependent proteolysis of Ira2p  regulated by G-alpha protein Gpa2p  homolog of Gpb2p
chrXV	1034806	1036471	1034806	1036471	-	NDD1	YOR372C		1034806,	1036471,	Transcriptional activator essential for nuclear division  localized to the nucleus  essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
chrXV	1036833	1039389	1036833	1039389	+	NUD1	YOR373W		1036833,	1039389,	Component of the spindle pole body outer plaque, required for exit from mitosis
chrXV	1039839	1041399	1039839	1041399	+	ALD4	YOR374W		1039839,	1041399,	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate  phosphorylated  activity is K+ dependent  utilizes NADP+ or NAD+ equally as coenzymes  expression is glucose repressed
chrXV	1041677	1043042	1041677	1043042	-	GDH1	YOR375C		1041677,	1043042,	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate  rate of alpha-ketoglutarate utilization differs from Gdh3p  expression regulated by nitrogen and carbon sources
chrXV	1043190	1043559	1043190	1043559	+	YOR376W	YOR376W		1043190,	1043559,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YOR376W is not an essential gene.
chrXV	1045195	1045351	1045195	1045351	+	YOR376W-A	YOR376W-A		1045195,	1045351,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXV	1046225	1047803	1046225	1047803	+	ATF1	YOR377W		1046225,	1047803,	Alcohol acetyltransferase with potential roles in lipid and sterol metabolism  responsible for the major part of volatile acetate ester production during fermentation
chrXV	1049510	1051058	1049510	1051058	+	YOR378W	YOR378W		1049510,	1051058,	Putative paralog of ATR1, but not required for boron tolerance  member of the DHA2 family of drug:H+ antiporters  YOR378W is not an essential gene
chrXV	1050725	1051064	1050725	1051064	-	YOR379C	YOR379C		1050725,	1051064,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized ORF YOR378W
chrXV	1051289	1052930	1051289	1052930	+	RDR1	YOR380W		1051289,	1052930,	Transcriptional repressor involved in the control of multidrug resistance  negatively regulates expression of the PDR5 gene  member of the Gal4p family of zinc cluster proteins
chrXV	1055544	1057680	1055544	1057680	+	FRE3	YOR381W		1055544,	1057680,	Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters  expression induced by low iron levels
chrXV	1058422	1058590	1058422	1058590	+	YOR381W-A	YOR381W-A		1058422,	1058590,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXV	1059530	1059992	1059530	1059992	+	FIT2	YOR382W		1059530,	1059992,	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
chrXV	1060440	1061055	1060440	1061055	-	FIT3	YOR383C		1060440,	1061055,	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
chrXV	1061563	1063648	1061563	1063648	+	FRE5	YOR384W		1061563,	1063648,	Putative ferric reductase with similarity to Fre2p  expression induced by low iron levels  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXV	1065042	1065915	1065042	1065915	+	YOR385W	YOR385W		1065042,	1065915,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YOR385W is not an essential gene
chrXV	1066838	1068536	1066838	1068536	+	PHR1	YOR386W		1066838,	1068536,	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light  induced by DNA damage  regulated by transcriptional repressor Rph1p
chrXV	1069620	1070241	1069620	1070241	-	YOR387C	YOR387C		1069620,	1070241,	Putative protein of unknown function  regulated by the metal-responsive Aft1p transcription factor  highly inducible in zinc-depleted conditions  localizes to the soluble fraction
chrXV	1071792	1072923	1071792	1072923	-	FDH1	YOR388C		1071792,	1072923,	NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
chrXV	1074212	1076087	1074212	1076087	+	YOR389W	YOR389W		1074212,	1076087,	Putative protein of unknown function  expression regulated by copper levels
chrXV	1076783	1077911	1076783	1077911	+	YOR390W	YOR390W		1076783,	1077911,	Putative protein of unknown function
chrXV	1078544	1079258	1078544	1079258	-	HSP33	YOR391C		1078544,	1079258,	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p  member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
chrXV	1079281	1079725	1079281	1079725	+	YOR392W	YOR392W		1079281,	1079725,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  gene expression induced by heat
chrXV	1080275	1081589	1080275	1081589	+	ERR1	YOR393W		1080275,	1081589,	Protein of unknown function, has similarity to enolases
chrXV	1082717	1083212	1082717	1083212	+	PAU21	YOR394W		1082717,	1083212,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions  identical to Pau22p  encodes 2 proteins that are translated from 2 different start codons
chrXV	1084201	1084369	1084201	1084369	-	YOR394C-A	YOR394C-A		1084201,	1084369,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXV	1085472	1090863	1085472	1090863	+	YRF1-8	YOR396W		1085472,	1090863,	One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1)
chrXV	1090014	1090497	1090014	1090497	-	YOR396C-A	YOR396C-A		1090014,	1090497,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	279	6007	279	6007	-	YRF1-7	YPL283C		279,5988,	5840,6007,	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1  potentially phosphorylated by Cdc28p
chrXVI	642	1125	642	1125	+	YPL283W-B	YPL283W-B		642,	1125,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	1425	2001	1425	2001	+	YPL283W-A	YPL283W-A		1425,	2001,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	7932	8427	7932	8427	-	PAU22	YPL282C		7932,	8427,	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions  identical to Pau21p  encodes 2 proteins that are translated from 2 different start codons
chrXVI	9556	10870	9556	10870	-	ERR2	YPL281C		9556,	10870,	Protein of unknown function, has similarity to enolases
chrXVI	11886	12600	11886	12600	+	HSP32	YPL280W		11886,	12600,	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p  member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
chrXVI	13227	14355	13227	14355	-	YPL279C	YPL279C		13227,	14355,	Putative protein of unknown function
chrXVI	15052	15355	15052	15355	-	YPL278C	YPL278C		15052,	15355,	Putative protein of unknown function  gene expression regulated by copper levels
chrXVI	15404	16868	15404	16868	-	YPL277C	YPL277C		15404,	16868,	Putative protein of unknown function  localized to the membranes  gene expression regulated by copper levels
chrXVI	22937	24701	22937	24701	+	SAM3	YPL274W		22937,	24701,	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source  has similarity to S-methylmethionine permease Mmp1p
chrXVI	25086	26064	25086	26064	+	SAM4	YPL273W		25086,	26064,	S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
chrXVI	26610	28164	26610	28164	-	YPL272C	YPL272C		26610,	28164,	Putative protein of unknown function  gene expression induced in response to ketoconazole  YPL272C is not an essential gene
chrXVI	30078	30267	30078	30267	+	ATP15	YPL271W		30078,	30267,	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis  phosphorylated
chrXVI	30481	32803	30481	32803	+	MDL2	YPL270W		30481,	32803,	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature  similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
chrXVI	33012	34947	33012	34947	+	KAR9	YPL269W		33012,	34947,	Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
chrXVI	35235	37845	35235	37845	+	PLC1	YPL268W		35235,	37845,	Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG)  involved in regulating many cellular processes
chrXVI	38168	38798	38168	38798	+	ACM1	YPL267W		38168,	38798,	Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins  associates with Cdh1p, Bmh1p and Bmh2p  cell cycle regulated protein
chrXVI	39120	40077	39120	40077	+	DIM1	YPL266W		39120,	40077,	Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
chrXVI	41042	42869	41042	42869	+	DIP5	YPL265W		41042,	42869,	Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate  also a transporter for Gln, Asn, Ser, Ala, and Gly
chrXVI	43282	44344	43282	44344	-	YPL264C	YPL264C		43282,	44344,	Putative membrane protein of unknown function  physically interacts with Hsp82p  YPL264C is not an essential gene
chrXVI	44550	46506	44550	46506	-	KEL3	YPL263C		44550,	46506,	Cytoplasmic protein of unknown function
chrXVI	47335	48802	47335	48802	+	FUM1	YPL262W		47335,	48802,	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle  cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt  phosphorylated in mitochondria
chrXVI	48995	49304	48995	49304	-	YPL261C	YPL261C		48995,	49304,	Dubious open reading frame unlikely to encode a protein  partially overlaps the uncharacterized ORF YPL260W
chrXVI	49302	50958	49302	50958	+	YPL260W	YPL260W		49302,	50958,	Putative substrate of cAMP-dependent protein kinase (PKA)  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  YPL260W is not an essential gene
chrXVI	51243	52671	51243	52671	-	APM1	YPL259C		51243,	52671,	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1)  binds clathrin  involved in clathrin-dependent Golgi protein sorting
chrXVI	53497	55153	53497	55153	-	THI21	YPL258C		53497,	55153,	Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis  member of a gene family with THI20 and THI22  Thi20p also has this activity
chrXVI	56747	62016	56747	62016	+	YPL257W-B	YPL257W-B		56747,58053,	58052,62016,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXVI	56747	58070	56747	58070	+	YPL257W-A	YPL257W-A		56747,	58070,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXVI	63278	63860	63278	63860	+	YPL257W	YPL257W		63278,	63860,	Putative protein of unknown function  homozygous diploid deletion strain exhibits low budding index  physically interacts with Hsp82p  YPL257W is not an essential gene
chrXVI	64976	66614	64976	66614	-	CLN2	YPL256C		64976,	66614,	G1 cyclin involved in regulation of the cell cycle  activates Cdc28p kinase to promote the G1 to S phase transition  late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
chrXVI	67724	68882	67724	68882	+	BBP1	YPL255W		67724,	68882,	Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery  forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p  required for mitotic functions of Cdc5p
chrXVI	69484	70951	69484	70951	+	HFI1	YPL254W		69484,	70951,	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
chrXVI	71062	73006	71062	73006	-	VIK1	YPL253C		71062,	73006,	Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes  required for sister chromatid cohesion  has similarity to Cik1p
chrXVI	73362	73881	73362	73881	-	YAH1	YPL252C		73362,	73881,	Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins  involved in heme A biosynthesis  homologous to human adrenodoxin
chrXVI	73624	73927	73624	73927	+	YPL251W	YPL251W		73624,	73927,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
chrXVI	74308	74719	74308	74719	-	ICY2	YPL250C		74308,	74719,	Protein of unknown function  mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source  potential Cdc28p substrate
chrXVI	75698	76239	75698	76239	-	RPL36B	YPL249C-A		75698,76223,	75985,76239,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein  binds to 5.8 S rRNA
chrXVI	75701	75989	75701	75989	+	YPL250W-A	YPL250W-A		75701,	75989,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  almost completely overlaps the verified ORF RPL36B/YPL249C-A  identified by fungal homology and RT-PCR
chrXVI	76668	79353	76668	79353	-	GYP5	YPL249C		76668,	79353,	GTPase-activating protein (GAP) for yeast Rab family members  involved in ER to Golgi trafficking  exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p  interacts with Gyl1p, Rvs161p and Rvs167p  involved in recruiting Rvs167p to the bud tip during polarized growth
chrXVI	79710	82356	79710	82356	-	GAL4	YPL248C		79710,	82356,	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose  repressed by Gal80p and activated by Gal3p
chrXVI	82624	84196	82624	84196	-	YPL247C	YPL247C		82624,	84196,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus  similar to the petunia WD repeat protein an11  overexpression causes a cell cycle delay or arrest
chrXVI	84508	85297	84508	85297	-	RBD2	YPL246C		84508,	85297,	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
chrXVI	85585	86950	85585	86950	+	YPL245W	YPL245W		85585,	86950,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
chrXVI	87013	88033	87013	88033	-	HUT1	YPL244C		87013,	88033,	Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
chrXVI	88516	90316	88516	90316	+	SRP68	YPL243W		88516,	90316,	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
chrXVI	90621	95109	90621	95109	-	IQG1	YPL242C		90621,	95109,	Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family
chrXVI	95371	96258	95371	96258	-	CIN2	YPL241C		95371,96233,	96153,96258,	GTPase-activating protein (GAP) for Cin4p  tubulin folding factor C involved in beta-tubulin (Tub2p) folding  mutants display increased chromosome loss and benomyl sensitivity  deletion complemented by human GAP, retinitis pigmentosa 2
chrXVI	96495	98625	96495	98625	-	HSP82	YPL240C		96495,	98625,	Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p  docks with Tom70p for mitochondrial preprotein delivery  promotes telomerase DNA binding and nucleotide addition  interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
chrXVI	99483	100086	99483	100086	+	YAR1	YPL239W		99483,	100086,	Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress  expression repressed by heat shock
chrXVI	100473	100863	100473	100863	-	YPL238C	YPL238C		100473,	100863,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  partially overlaps 5' end of the verified essential gene SUI3/YPL237W
chrXVI	100495	101353	100495	101353	+	SUI3	YPL237W		100495,	101353,	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon  proposed to be involved in mRNA binding
chrXVI	101607	102702	101607	102702	-	YPL236C	YPL236C		101607,	102702,	
chrXVI	103231	104647	103231	104647	+	RVB2	YPL235W		103231,	104647,	Essential protein involved in transcription regulation  component of chromatin remodeling complexes  required for assembly and function of the INO80 complex  also referred to as reptin  member of the RUVB-like protein family
chrXVI	104945	105440	104945	105440	-	VMA11	YPL234C		104945,	105440,	Vacuolar ATPase V0 domain subunit c', involved in proton transport activity  hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments  N and C termini are in the vacuolar lumen
chrXVI	106171	106822	106171	106822	+	NSL1	YPL233W		106171,	106822,	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules  required for accurate chromosome segregation
chrXVI	107274	108147	107274	108147	+	SSO1	YPL232W		107274,	108147,	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation  forms a complex with Sec9p that binds v-SNARE Snc2p  syntaxin homolog  functionally redundant with Sso2p
chrXVI	108651	114315	108651	114315	+	FAS2	YPL231W		108651,	114315,	Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids  contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
chrXVI	115311	116487	115311	116487	+	USV1	YPL230W		115311,	116487,	Putative transcription factor containing a C2H2 zinc finger  mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis
chrXVI	117066	117687	117066	117687	+	YPL229W	YPL229W		117066,	117687,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YPL229W is not an essential gene
chrXVI	118381	120031	118381	120031	+	CET1	YPL228W		118381,	120031,	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA  the mammalian enzyme is a single bifunctional polypeptide
chrXVI	120162	121167	120162	121167	-	ALG5	YPL227C		120162,	121167,	UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
chrXVI	121766	125357	121766	125357	+	NEW1	YPL226W		121766,	125357,	ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit  Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction
chrXVI	126005	126446	126005	126446	+	YPL225W	YPL225W		126005,	126446,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXVI	126633	128088	126633	128088	-	MMT2	YPL224C		126633,	128088,	Putative metal transporter involved in mitochondrial iron accumulation  closely related to Mmt1p
chrXVI	128631	129138	128631	129138	-	GRE1	YPL223C		128631,	129138,	Hydrophilin of unknown function  stress induced (osmotic, ionic, oxidative, heat shock and heavy metals)  regulated by the HOG pathway
chrXVI	130161	132228	130161	132228	+	FMP40	YPL222W		130161,	132228,	Putative protein of unknown function  proposed to be involved in responding to environmental stresses  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXVI	131869	132115	131869	132115	-	YPL222C-A	YPL222C-A		131869,	132115,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	133042	135424	133042	135424	+	FLC1	YPL221W		133042,	135424,	Putative FAD transporter  required for uptake of FAD into endoplasmic reticulum  involved in cell wall maintenance
chrXVI	135789	136443	135789	136443	+	RPL1A	YPL220W		135789,	136443,	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins  rpl1a rpl1b double null mutation is lethal
chrXVI	136749	138228	136749	138228	+	PCL8	YPL219W		136749,	138228,	Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
chrXVI	138697	139409	138697	139409	+	SAR1	YPL218W		138697,138864,	138725,139409,	GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles  required for transport vesicle formation during ER to Golgi protein transport
chrXVI	139619	143171	139619	143171	-	BMS1	YPL217C		139619,	143171,	GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2  interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities  has similarity to Tsr1p
chrXVI	143820	147129	143820	147129	+	YPL216W	YPL216W		143820,	147129,	Putative protein of unknown function  YPL216W is not an essential gene
chrXVI	147415	148423	147415	148423	+	CBP3	YPL215W		147415,	148423,	Mitochondrial protein required for assembly of cytochrome bc1 complex  forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA  Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
chrXVI	148568	150191	148568	150191	-	THI6	YPL214C		148568,	150191,	Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis  GFP-fusion protein localizes to the cytoplasm in a punctate pattern
chrXVI	150613	151330	150613	151330	+	LEA1	YPL213W		150613,	151330,	Component of U2 snRNP  disruption causes reduced U2 snRNP levels  physically interacts with Msl1p  putative homolog of human U2A' snRNP protein
chrXVI	151514	153149	151514	153149	-	PUS1	YPL212C		151514,	153149,	tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA  nuclear protein that appears to be involved in tRNA export  also acts on U2 snRNA
chrXVI	153494	154040	153494	154040	+	NIP7	YPL211W		153494,	154040,	Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles  physically interacts with Nop8p and the exosome subunit Rrp43p
chrXVI	154289	156212	154289	156212	-	SRP72	YPL210C		154289,	156212,	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
chrXVI	156489	157593	156489	157593	-	IPL1	YPL209C		156489,	157593,	Aurora kinase subunit of the conserved chromosomal passenger complex (CPC  Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments  helps maintain condensed chromosomes during anaphase and early telophase
chrXVI	157841	159593	157841	159593	+	RKM1	YPL208W		157841,	159593,	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)
chrXVI	159908	162341	159908	162341	+	TYW1	YPL207W		159908,	162341,	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
chrXVI	162631	163597	162631	163597	-	PGC1	YPL206C		162631,	163597,	Phosphatidyl Glycerol phospholipase C  regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism  contains glycerophosphodiester phosphodiesterase motifs
chrXVI	163921	164266	163921	164266	-	YPL205C	YPL205C		163921,	164266,	Hypothetical protein  deletion of locus affects telomere length
chrXVI	164275	165760	164275	165760	+	HRR25	YPL204W		164275,	165760,	Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation  binds the CTD of RNA pol II  homolog of mammalian casein kinase 1delta (CK1delta)
chrXVI	166255	167398	166255	167398	+	TPK2	YPL203W		166255,	167398,	cAMP-dependent protein kinase catalytic subunit  promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway  partially redundant with Tpk1p and Tpk3p  localizes to P-bodies during stationary phase
chrXVI	168087	169338	168087	169338	-	AFT2	YPL202C		168087,	169338,	Iron-regulated transcriptional activator  activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress  similar to Aft1p
chrXVI	169769	171155	169769	171155	-	YIG1	YPL201C		169769,	171155,	Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production  localizes to the nucleus and cytosol
chrXVI	171483	171954	171483	171954	+	CSM4	YPL200W		171483,	171954,	Protein required for accurate chromosome segregation during meiosis  involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
chrXVI	172032	172755	172032	172755	-	YPL199C	YPL199C		172032,	172755,	Putative protein of unknown function, predicted to be palmitoylated
chrXVI	173151	174702	173151	174702	+	RPL7B	YPL198W		173151,173571,174072,	173162,173665,174702,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins  contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
chrXVI	174342	174756	174342	174756	-	YPL197C	YPL197C		174342,	174756,	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data  partially overlaps the ribosomal gene RPB7B
chrXVI	175042	175864	175042	175864	+	OXR1	YPL196W		175042,	175864,	Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide  member of a conserved family of proteins found in eukaryotes
chrXVI	176222	179021	176222	179021	+	APL5	YPL195W		176222,	179021,	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3)  functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
chrXVI	179276	181115	179276	181115	+	DDC1	YPL194W		179276,	181115,	DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates  potential Cdc28p substrate
chrXVI	181402	182548	181402	182548	+	RSA1	YPL193W		181402,	182548,	Protein involved in the assembly of 60S ribosomal subunits  functionally interacts with Dbp6p  functions in a late nucleoplasmic step of the assembly
chrXVI	182654	183056	182654	183056	-	PRM3	YPL192C		182654,	183056,	Pheromone-regulated protein required for nuclear envelope fusion during karyogamy  localizes to the outer face of the nuclear membrane  interacts with Kar5p at the spindle pole body
chrXVI	183596	184679	183596	184679	-	YPL191C	YPL191C		183596,	184679,	Putative protein of unknown function  diploid deletion strain exhibits high budding index  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXVI	185316	187725	185316	187725	-	NAB3	YPL190C		185316,	187725,	Single stranded RNA binding protein  acidic ribonucleoprotein  required for termination of non-poly(A) transcripts and efficient splicing  interacts with Nrd1p
chrXVI	188306	188513	188306	188513	-	COA2	YPL189C-A		188306,	188513,	Cytochrome oxidase assembly factor  null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity  functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
chrXVI	189153	190983	189153	190983	+	GUP2	YPL189W		189153,	190983,	Probable membrane protein with a possible role in proton symport of glycerol  member of the MBOAT family of putative membrane-bound O-acyltransferases  Gup1p homolog
chrXVI	191405	192650	191405	192650	+	POS5	YPL188W		191405,	192650,	Mitochondrial NADH kinase, phosphorylates NADH  also phosphorylates NAD(+) with lower specificity  required for the response to oxidative stress
chrXVI	193647	194145	193647	194145	+	MF(ALPHA)1	YPL187W		193647,	194145,	Mating pheromone alpha-factor, made by alpha cells  interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating  also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
chrXVI	194511	195426	194511	195426	-	UIP4	YPL186C		194511,	195426,	Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates  detected in a phosphorylated state in the mitochondrial outer membrane  also detected in ER and nuclear envelope
chrXVI	195252	195648	195252	195648	+	YPL185W	YPL185W		195252,	195648,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene UIP4/YPL186C
chrXVI	195949	197788	195949	197788	-	MRN1	YPL184C		195949,	197788,	RNA-binding protein proposed to be involved in translational regulation  binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES)
chrXVI	199094	199376	199094	199376	+	RTC6	YPL183W-A		199094,	199376,	Protein involved translation  mutants have defects in biogenesis of nuclear ribosomes  sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein encoded in the nucleus
chrXVI	199494	202536	199494	202536	-	RTT10	YPL183C		199494,	202536,	Cytoplasmic protein with a role in regulation of Ty1 transposition
chrXVI	203305	203689	203305	203689	-	YPL182C	YPL182C		203305,	203689,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene CTI6/YPL181W
chrXVI	203420	204941	203420	204941	+	CTI6	YPL181W		203420,	204941,	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter  contains a PHD finger domain
chrXVI	205247	207647	205247	207647	+	TCO89	YPL180W		205247,	207647,	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability  cooperates with Ssd1p in the maintenance of cellular integrity  deletion strains are hypersensitive to rapamycin
chrXVI	208156	209806	208156	209806	+	PPQ1	YPL179W		208156,	209806,	Putative protein serine/threonine phosphatase  null mutation enhances efficiency of translational suppressors
chrXVI	212157	212784	212157	212784	+	CBC2	YPL178W		212157,	212784,	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex  interacts with Npl3p, possibly to package mRNA for export from the nucleus  contains an RNA-binding motif
chrXVI	213041	213962	213041	213962	-	CUP9	YPL177C		213041,	213962,	Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter  imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
chrXVI	216011	218363	216011	218363	-	TRE1	YPL176C		216011,	218363,	Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p  function is redundant with that of Tre2p  has similarity to transferrin receptors
chrXVI	218629	220088	218629	220088	+	SPT14	YPL175W		218629,218746,	218646,220088,	UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
chrXVI	220166	222773	220166	222773	-	NIP100	YPL174C		220166,	222773,	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells  putative ortholog of mammalian p150(glued)
chrXVI	223142	224036	223142	224036	+	MRPL40	YPL173W		223142,	224036,	Mitochondrial ribosomal protein of the large subunit
chrXVI	224352	225741	224352	225741	-	COX10	YPL172C		224352,	225741,	Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity  human ortholog is associated with mitochondrial disorders
chrXVI	226168	227371	226168	227371	-	OYE3	YPL171C		226168,	227371,	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties  has potential roles in oxidative stress response and programmed cell death
chrXVI	228313	228772	228313	228772	+	DAP1	YPL170W		228313,	228772,	Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p  damage response protein, related to mammalian membrane progesterone receptors  mutations lead to defects in telomeres, mitochondria, and sterol synthesis
chrXVI	229038	230838	229038	230838	-	MEX67	YPL169C		229038,	230838,	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore  ortholog of human TAP
chrXVI	231216	232509	231216	232509	+	YPL168W	YPL168W		231216,	232509,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion  expression may be cell cycle-regulated
chrXVI	232592	237107	232592	237107	-	REV3	YPL167C		232592,	237107,	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair  required for mutagenesis induced by DNA damage  involved in double-strand break repair
chrXVI	237337	237979	237337	237979	+	ATG29	YPL166W		237337,	237979,	Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS)  interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p  not conserved
chrXVI	237955	239077	237955	239077	-	SET6	YPL165C		237955,	239077,	SET domain protein of unknown function  deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
chrXVI	239349	241497	239349	241497	-	MLH3	YPL164C		239349,	241497,	Protein involved in DNA mismatch repair and crossing-over during meiotic recombination  forms a complex with Mlh1p  mammalian homolog is implicated mammalian microsatellite instability
chrXVI	241917	242700	241917	242700	-	SVS1	YPL163C		241917,	242700,	Cell wall and vacuolar protein, required for wild-type resistance to vanadate
chrXVI	243205	244027	243205	244027	-	YPL162C	YPL162C		243205,	244027,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
chrXVI	244318	246220	244318	246220	-	BEM4	YPL161C		244318,	246220,	Protein involved in establishment of cell polarity and bud emergence  interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p  involved in maintenance of proper telomere length
chrXVI	246989	250262	246989	250262	+	CDC60	YPL160W		246989,	250262,	Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
chrXVI	250906	251668	250906	251668	-	PET20	YPL159C		250906,	251668,	Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
chrXVI	252033	254310	252033	254310	-	AIM44	YPL158C		252033,	254310,	Protein of unknown function  GFP-fusion protein localizes to the bud neck  transcription is regulated by Swi5p  null mutant displays elevated frequency of mitochondrial genome loss
chrXVI	254813	255761	254813	255761	+	TGS1	YPL157W		254813,	255761,	Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G  also required for nucleolar assembly and splicing of meiotic pre-mRNAs
chrXVI	255912	256767	255912	256767	-	PRM4	YPL156C		255912,	256767,	Pheromone-regulated protein proposed to be involved in mating  predicted to have 1 transmembrane segment  transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
chrXVI	257215	259336	257215	259336	-	KIP2	YPL155C		257215,	259336,	Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end  Kip2p levels are controlled during the cell cycle
chrXVI	259713	260931	259713	260931	-	PEP4	YPL154C		259713,	260931,	Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases  important for protein turnover after oxidative damage  synthesized as a zymogen, self-activates
chrXVI	261726	264192	261726	264192	-	RAD53	YPL153C		261726,	264192,	Protein kinase, required for cell-cycle arrest in response to DNA damage  activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p  also interacts with ARS1 and plays a role in initiation of DNA replication
chrXVI	264601	264700	264601	264700	+	YPL152W-A	YPL152W-A		264601,	264700,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	265027	266104	265027	266104	+	RRD2	YPL152W		265027,	266104,	Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase  regulates G1 phase progression, the osmoresponse, microtubule dynamics  subunit of the Tap42p-Pph21p-Rrd2p complex
chrXVI	266179	267535	266179	267535	-	PRP46	YPL151C		266179,	267535,	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
chrXVI	268187	270893	268187	270893	+	YPL150W	YPL150W		268187,	270893,	Putative protein kinase of unknown cellular role  binds phosphatidylinositols and cardiolipin in a large-scale study
chrXVI	271309	272194	271309	272194	+	ATG5	YPL149W		271309,	272194,	Conserved protein involved in autophagy and the Cvt pathway  undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation  conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
chrXVI	272293	272815	272293	272815	-	PPT2	YPL148C		272293,	272815,	Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
chrXVI	273254	275867	273254	275867	+	PXA1	YPL147W		273254,	275867,	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes  similarity to human adrenoleukodystrophy transporter and ALD-related proteins
chrXVI	276161	277529	276161	277529	-	NOP53	YPL146C		276161,	277529,	Nucleolar protein  involved in biogenesis of the 60S subunit of the ribosome  interacts with rRNA processing factors Cbf5p and Nop2p  null mutant is viable but growth is severely impaired
chrXVI	278394	279699	278394	279699	-	KES1	YPL145C		278394,	279699,	Member of the oxysterol binding protein family, which includes seven yeast homologs  involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
chrXVI	280479	280926	280479	280926	+	POC4	YPL144W		280479,	280926,	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome  may regulate formation of proteasome isoforms with alternative subunits under different conditions
chrXVI	282121	282970	282121	282970	+	RPL33A	YPL143W		282121,282665,	282140,282970,	N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a  rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
chrXVI	282685	283003	282685	283003	-	YPL142C	YPL142C		282685,	283003,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
chrXVI	283463	286061	283463	286061	-	FRK1	YPL141C		283463,	286061,	Putative protein kinase  similar to Kin4p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3
chrXVI	287513	289034	287513	289034	-	MKK2	YPL140C		287513,	289034,	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity  upon activation by Bck1p phosphorylates downstream target, Slt2p  functionally redundant with Mkk1p
chrXVI	289668	291051	289668	291051	-	UME1	YPL139C		289668,	291051,	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif  homologous with Wtm1p, Wtm2p
chrXVI	291365	292427	291365	292427	-	SPP1	YPL138C		291365,	292427,	Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing  interacts with Orc2p  PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
chrXVI	292816	296647	292816	296647	-	GIP3	YPL137C		292816,	296647,	Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation  may interact with ribosomes, based on co-purification experiments
chrXVI	296285	296654	296285	296654	+	YPL136W	YPL136W		296285,	296654,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the verified gene GIP3/YPL137C
chrXVI	297552	298050	297552	298050	+	ISU1	YPL135W		297552,	298050,	Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p)  isu1 isu2 double mutant is inviable
chrXVI	297677	297851	297677	297851	-	YPL135C-A	YPL135C-A		297677,	297851,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	298570	299503	298570	299503	-	ODC1	YPL134C		298570,	299503,	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism  suppresses, in multicopy, an fmc1 null mutation
chrXVI	299887	301228	299887	301228	-	RDS2	YPL133C		299887,	301228,	Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes  member of the zinc cluster family of proteins  confers resistance to ketoconazole
chrXVI	301715	302618	301715	302618	+	COX11	YPL132W		301715,	302618,	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase  association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
chrXVI	303120	304014	303120	304014	+	RPL5	YPL131W		303120,	304014,	Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins  binds 5S rRNA and is required for 60S subunit assembly
chrXVI	304386	305058	304386	305058	+	SPO19	YPL130W		304386,	305058,	Meiosis-specific prospore protein  required to produce bending force necessary for proper assembly of the prospore membrane during sporulation  identified as a weak high-copy suppressor of the spo1-1 ts mutation
chrXVI	305297	306137	305297	306137	+	TAF14	YPL129W		305297,305411,	305306,306137,	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification  contains a YEATS domain
chrXVI	306532	308221	306532	308221	-	TBF1	YPL128C		306532,	308221,	Telobox-containing general regulatory factor  binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation  binds majority of snoRNA gene promoters, required for full snoRNA expression
chrXVI	308827	309604	308827	309604	-	HHO1	YPL127C		308827,	309604,	Histone H1, a linker histone required for nucleosome packaging at restricted sites  suppresses DNA repair involving homologous recombination  not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
chrXVI	310209	312900	310209	312900	+	NAN1	YPL126W		310209,	312900,	U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA  required for the biogenesis of18S rRNA
chrXVI	313387	316486	313387	316486	+	KAP120	YPL125W		313387,	316486,	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
chrXVI	316754	317516	316754	317516	+	SPC29	YPL124W		316754,	317516,	Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p  required for SPB duplication
chrXVI	317640	318945	317640	318945	-	RNY1	YPL123C		317640,	318945,	Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress  promotes apoptosis under stress conditions and this function is independent of its catalytic activity
chrXVI	319225	320767	319225	320767	-	TFB2	YPL122C		319225,	320767,	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
chrXVI	320961	321630	320961	321630	-	MEI5	YPL121C		320961,	321630,	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p  proposed to be an assembly factor for Dmc1p
chrXVI	322070	323744	322070	323744	+	VPS30	YPL120W		322070,	323744,	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II  Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting  ortholog of the higher eukaryotic gene Beclin 1
chrXVI	324023	324287	324023	324287	-	YPL119C-A	YPL119C-A		324023,	324287,	Putative protein of unknown function  identified by expression profiling and mass spectrometry
chrXVI	324410	326264	324410	326264	-	DBP1	YPL119C		324410,	326264,	Putative ATP-dependent RNA helicase of the DEAD-box protein family  mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
chrXVI	326627	327662	326627	327662	+	MRP51	YPL118W		326627,	327662,	Mitochondrial ribosomal protein of the small subunit  MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
chrXVI	327863	328730	327863	328730	-	IDI1	YPL117C		327863,	328730,	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway  required for viability
chrXVI	329605	331699	329605	331699	+	HOS3	YPL116W		329605,	331699,	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B  similar to Hda1p, Rpd3p, Hos1p, and Hos2p  deletion results in increased histone acetylation at rDNA repeats
chrXVI	332099	335486	332099	335486	-	BEM3	YPL115C		332099,	335486,	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization  targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
chrXVI	335947	336367	335947	336367	+	YPL114W	YPL114W		335947,	336367,	Dubious open reading frame, unlikely to encode a functional protein  largely overlaps ORF YPL113C  diploid deletion in BY4743 strain background exhibits high budding index
chrXVI	335952	337143	335952	337143	-	YPL113C	YPL113C		335952,	337143,	Glyoxylate reductase  acts on glyoxylate and hydroxypyruvate substrates  YPL113C is not an essential gene
chrXVI	337435	338620	337435	338620	-	PEX25	YPL112C		337435,	338620,	Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
chrXVI	339943	340945	339943	340945	+	CAR1	YPL111W		339943,	340945,	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression  disruption enhances freeze tolerance
chrXVI	341067	344739	341067	344739	-	GDE1	YPL110C		341067,	344739,	Glycerophosphocholine (GroPCho) phosphodiesterase  hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis  may interact with ribosomes
chrXVI	345263	347389	345263	347389	-	YPL109C	YPL109C		345263,345596,	345444,347389,	Putative protein of unknown function  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXVI	348445	348952	348445	348952	+	YPL108W	YPL108W		348445,	348952,	Cytoplasmic protein of unknown function  non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism  GFP-fusion protein is induced in response to the DNA-damaging agent MMS
chrXVI	349118	349865	349118	349865	+	YPL107W	YPL107W		349118,	349865,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to mitochondria  YPL107W is not an essential gene
chrXVI	350193	352275	350193	352275	-	SSE1	YPL106C		350193,	352275,	ATPase that is a component of the heat shock protein Hsp90 chaperone complex  binds unfolded proteins  member of the heat shock protein 70 (HSP70) family  localized to the cytoplasm
chrXVI	352862	355412	352862	355412	-	SYH1	YPL105C		352862,	355412,	Protein of unknown function that influences nuclear pore distribution  co-purifies with ribosomes  contains a GYF domain, which bind proline-rich sequences  deletion extends chronological lifespan
chrXVI	355699	357676	355699	357676	+	MSD1	YPL104W		355699,	357676,	Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA  yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene
chrXVI	357999	359406	357999	359406	-	FMP30	YPL103C		357999,	359406,	Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels  proposed to be involved in N-acylethanolamine metabolism  related to mammalian N-acylPE-specific phospholipase D
chrXVI	360002	360305	360002	360305	-	YPL102C	YPL102C		360002,	360305,	Dubious open reading frame, not conserved in closely related Saccharomyces species  deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4
chrXVI	360208	361579	360208	361579	+	ELP4	YPL101W		360208,	361579,	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA  required for Elongator structural integrity
chrXVI	361871	363362	361871	363362	+	ATG21	YPL100W		361871,	363362,	Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway  binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate  WD-40 repeat protein
chrXVI	363519	364068	363519	364068	-	AIM43	YPL099C		363519,	364068,	Protein of unknown function  the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies  null mutant displays elevated frequency of mitochondrial genome loss
chrXVI	364385	364727	364385	364727	-	MGR2	YPL098C		364385,	364727,	Protein required for growth of cells lacking the mitochondrial genome
chrXVI	364951	366430	364951	366430	+	MSY1	YPL097W		364951,	366430,	Mitochondrial tyrosyl-tRNA synthetase
chrXVI	366528	366735	366528	366735	-	ERI1	YPL096C-A		366528,	366735,	Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER  component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis  probable homolog of mammalian PIG-Y protein
chrXVI	366926	368018	366926	368018	+	PNG1	YPL096W		366926,	368018,	Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation  localizes to the cytoplasm and nucleus  activity is enhanced by interaction with Rad23p
chrXVI	368070	369441	368070	369441	-	EEB1	YPL095C		368070,	369441,	Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation  possesses short-chain esterase activity  may be involved in lipid metabolism and detoxification
chrXVI	369838	370663	369838	370663	-	SEC62	YPL094C		369838,	370663,	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)  with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
chrXVI	370977	372921	370977	372921	+	NOG1	YPL093W		370977,	372921,	Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis  constituent of 66S pre-ribosomal particles  member of the ODN family of nucleolar G-proteins
chrXVI	373792	375169	373792	375169	+	SSU1	YPL092W		373792,	375169,	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux  major facilitator superfamily protein
chrXVI	375501	376953	375501	376953	+	GLR1	YPL091W		375501,	376953,	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione  mitochondrial but not cytosolic form has a role in resistance to hyperoxia
chrXVI	377290	378395	377290	378395	-	RPS6A	YPL090C		377290,378389,	377995,378395,	Protein component of the small (40S) ribosomal subunit  identical to Rps6Bp and has similarity to rat S6 ribosomal protein
chrXVI	379119	381150	379119	381150	-	RLM1	YPL089C		379119,	381150,	MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity  phosphorylated and activated by the MAP-kinase Slt2p
chrXVI	381964	382993	381964	382993	+	YPL088W	YPL088W		381964,	382993,	Putative aryl alcohol dehydrogenase  transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
chrXVI	383454	384408	383454	384408	+	YDC1	YPL087W		383454,	384408,	Alkaline dihydroceramidase, involved in sphingolipid metabolism  preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine  has a minor reverse activity
chrXVI	384772	386446	384772	386446	-	ELP3	YPL086C		384772,	386446,	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA  exhibits histone acetyltransferase activity that is directed to histones H3 and H4  disruption confers resistance to K. lactis zymotoxin
chrXVI	387066	393654	387066	393654	+	SEC16	YPL085W		387066,	393654,	COPII vesicle coat protein required for ER transport vesicle budding  Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes  interacts with Sec23p, Sec24p and Sec31p
chrXVI	394037	396572	394037	396572	+	BRO1	YPL084W		394037,	396572,	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
chrXVI	396701	398105	396701	398105	-	SEN54	YPL083C		396701,	398105,	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
chrXVI	398479	404083	398479	404083	-	MOT1	YPL082C		398479,	404083,	Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
chrXVI	404949	406044	404949	406044	+	RPS9A	YPL081W		404949,405457,	404956,406044,	Protein component of the small (40S) ribosomal subunit  nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
chrXVI	406171	406498	406171	406498	-	YPL080C	YPL080C		406171,	406498,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXVI	406635	407539	406635	407539	+	RPL21B	YPL079W		406635,407067,	406646,407539,	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
chrXVI	408009	408744	408009	408744	-	ATP4	YPL078C		408009,	408744,	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis  contributes to the oligomerization of the complex  phosphorylated
chrXVI	409367	410090	409367	410090	-	YPL077C	YPL077C		409367,	410090,	Putative protein of unknown function  regulates PIS1 expression  mutant displays spore wall assembly defect in ether sensitivity screen  YPL077C is not an essential gene
chrXVI	410442	411285	410442	411285	+	GPI2	YPL076W		410442,	411285,	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors  homologous to the human PIG-C protein
chrXVI	412253	415362	412253	415362	+	GCR1	YPL075W		412253,413012,	412261,415362,	Transcriptional activator of genes involved in glycolysis  DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
chrXVI	415762	418027	415762	418027	+	YTA6	YPL074W		415762,	418027,	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells
chrXVI	418498	418984	418498	418984	-	YPL073C	YPL073C		418498,	418984,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps with verified gene UBP16/YPL072W  may interact with ribosome based on co-purification experiments
chrXVI	418511	420011	418511	420011	+	UBP16	YPL072W		418511,	420011,	Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
chrXVI	420047	420518	420047	420518	-	YPL071C	YPL071C		420047,	420518,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrXVI	420947	422786	420947	422786	+	MUK1	YPL070W		420947,	422786,	Cytoplasmic protein of unknown function containing a Vps9 domain  computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
chrXVI	422884	423892	422884	423892	-	BTS1	YPL069C		422884,	423892,	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
chrXVI	424214	425096	424214	425096	-	YPL068C	YPL068C		424214,	425096,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS
chrXVI	425250	425847	425250	425847	-	YPL067C	YPL067C		425250,	425847,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm  YPL067C is not an essential gene
chrXVI	426232	427672	426232	427672	+	YPL066W	YPL066W		426232,	427672,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm  null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
chrXVI	427926	428655	427926	428655	+	VPS28	YPL065W		427926,	428655,	Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome  conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
chrXVI	428710	429616	428710	429616	-	CWC27	YPL064C		428710,	429616,	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing  has similarity to S. pombe Cwf27p
chrXVI	429938	431369	429938	431369	+	TIM50	YPL063W		429938,	431369,	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)  acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex  may control the gating of the Tim23p-Tim17p channel
chrXVI	431894	432299	431894	432299	+	YPL062W	YPL062W		431894,	432299,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YPL062W is not an essential gene  homozygous diploid mutant shows a decrease in glycogen accumulation
chrXVI	432587	434090	432587	434090	+	ALD6	YPL061W		432587,	434090,	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme  required for conversion of acetaldehyde to acetate  constitutively expressed  locates to the mitochondrial outer surface upon oxidative stress
chrXVI	434522	435764	434522	435764	+	MFM1	YPL060W		434522,	435764,	Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential  indirectly affects splicing of group II introns  functionally and structurally related to Mrs2p
chrXVI	444578	445031	444578	445031	+	GRX5	YPL059W		444578,	445031,	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase  mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers  monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
chrXVI	445841	450377	445841	450377	-	PDR12	YPL058C		445841,	450377,	Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance  induced by sorbate and benzoate and regulated by War1p  mutants exhibit sorbate hypersensitivity
chrXVI	451908	453057	451908	453057	-	SUR1	YPL057C		451908,	453057,	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p  function in sphingolipid biosynthesis is overlapping with that of Csh1p
chrXVI	453429	453735	453429	453735	-	LCL1	YPL056C		453429,	453735,	Putative protein of unknown function  deletion mutant is fluconazole resistant and has long chronological lifespan
chrXVI	453991	454990	453991	454990	-	LGE1	YPL055C		453991,	454990,	Protein of unknown function  null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
chrXVI	455758	456664	455758	456664	+	LEE1	YPL054W		455758,	456664,	Zinc-finger protein of unknown function
chrXVI	457117	458458	457117	458458	-	KTR6	YPL053C		457117,	458458,	Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway  member of the KRE2/MNT1 mannosyltransferase family
chrXVI	458798	459678	458798	459678	+	OAZ1	YPL052W		458798,459006,	459005,459678,	Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation  ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated
chrXVI	459962	460559	459962	460559	+	ARL3	YPL051W		459962,	460559,	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi  similar to ADP-ribosylation factor
chrXVI	460778	461966	460778	461966	-	MNN9	YPL050C		460778,	461966,	Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone  forms a separate complex with Van1p that is also involved in backbone elongation
chrXVI	462480	463839	462480	463839	-	DIG1	YPL049C		462480,	463839,	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway  related regulators Dig1p and Dig2p bind to Ste12p
chrXVI	464400	465648	464400	465648	+	CAM1	YPL048W		464400,	465648,	Nuclear protein required for transcription of MXR1  binds the MXR1 promoter in the presence of other nuclear factors  binds calcium and phospholipids  has similarity to translational cofactor EF-1 gamma
chrXVI	465961	466261	465961	466261	+	SGF11	YPL047W		465961,	466261,	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
chrXVI	466643	466943	466643	466943	-	ELC1	YPL046C		466643,	466943,	Elongin C, involved in transcription elongation as a heterodimer with Ela1p  forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis  plays a role in global genomic repair
chrXVI	467259	469656	467259	469656	+	VPS16	YPL045W		467259,	469656,	Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex  part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
chrXVI	469925	470474	469925	470474	-	YPL044C	YPL044C		469925,	470474,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene NOP4/YPL043W
chrXVI	469938	471996	469938	471996	+	NOP4	YPL043W		469938,	471996,	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis  constituent of 66S pre-ribosomal particles  contains four RNA recognition motifs (RRMs)
chrXVI	473039	474707	473039	474707	-	SSN3	YPL042C		473039,	474707,	Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme  involved in phosphorylation of the RNA polymerase II C-terminal domain  involved in glucose repression
chrXVI	475117	475741	475117	475741	-	YPL041C	YPL041C		475117,	475741,	Protein of unknown function involved in maintenance of proper telomere length
chrXVI	475992	479001	475992	479001	-	ISM1	YPL040C		475992,	479001,	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
chrXVI	479224	480175	479224	480175	+	YPL039W	YPL039W		479224,	480175,	Putative protein of unknown function  YPL039W is not an essential gene
chrXVI	480181	480373	480181	480373	+	YPL038W-A	YPL038W-A		480181,	480373,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXVI	480534	481068	480534	481068	+	MET31	YPL038W		480534,	481068,	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p
chrXVI	481427	481901	481427	481901	-	EGD1	YPL037C		481427,	481901,	Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes  enhances DNA binding of the Gal4p activator  homolog of human BTF3b
chrXVI	482842	485686	482842	485686	+	PMA2	YPL036W		482842,	485686,	Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell  regulator of cytoplasmic pH and plasma membrane potential
chrXVI	486563	486911	486563	486911	-	YPL035C	YPL035C		486563,	486911,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the uncharacterized gene YPL034W  YPL035C is not an essential gene
chrXVI	486711	487209	486711	487209	+	YPL034W	YPL034W		486711,	487209,	Putative protein of unknown function  YPL034W is not essential gene
chrXVI	487361	488207	487361	488207	-	SRL4	YPL033C		487361,	488207,	Protein of unknown function  involved in regulation of dNTP production  null mutant suppresses the lethality of lcd1 and rad53 mutations  expression is induced by Kar4p
chrXVI	488886	491364	488886	491364	-	SVL3	YPL032C		488886,	491364,	Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function  green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
chrXVI	492017	493037	492017	493037	-	PHO85	YPL031C		492017,493020,	492918,493037,	Cyclin-dependent kinase, with ten cyclin partners  involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
chrXVI	493542	495246	493542	495246	+	TRM44	YPL030W		493542,	495246,	tRNA(Ser) Um(44) 2'-O-methyltransferase  involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA)  conserved among metazoans and fungi but there does not appear to be a homolog in plants  TRM44 is a non-essential gene
chrXVI	495505	497719	495505	497719	+	SUV3	YPL029W		495505,	497719,	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p  the degradosome associates with the ribosome and mediates RNA turnover  also required during splicing of the COX1 AI5_beta intron
chrXVI	498095	499292	498095	499292	+	ERG10	YPL028W		498095,	499292,	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA  involved in the first step in mevalonate biosynthesis
chrXVI	499664	500402	499664	500402	+	SMA1	YPL027W		499664,	500402,	Protein of unknown function involved in the assembly of the prospore membrane during sporulation  interacts with Spo14p
chrXVI	500674	502183	500674	502183	-	SKS1	YPL026C		500674,	502183,	Putative serine/threonine protein kinase  involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
chrXVI	502472	503030	502472	503030	-	YPL025C	YPL025C		502472,	503030,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXVI	503516	504242	503516	504242	+	RMI1	YPL024W		503516,	504242,	Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex  stimulates superhelical relaxing and ssDNA binding activities of Top3p  involved in response to DNA damage  null mutants display increased rates of recombination and delayed S phase
chrXVI	504338	506312	504338	506312	-	MET12	YPL023C		504338,	506312,	Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro  null mutant has no phenotype and is prototrophic for methionine  MET13 encodes major isozyme of MTHFR
chrXVI	506696	509999	506696	509999	+	RAD1	YPL022W		506696,	509999,	Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair  subunit of Nucleotide Excision Repair Factor 1 (NEF1)  homolog of human XPF protein
chrXVI	511100	511664	511100	511664	+	ECM23	YPL021W		511100,	511664,	Non-essential protein of unconfirmed function  affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth  homologous to Srd1p
chrXVI	512312	514178	512312	514178	-	ULP1	YPL020C		512312,	514178,	Protease that specifically cleaves Smt3p protein conjugates  required for cell cycle progression  associates with nucleoporins and may interact with septin rings during telophase  sequestered to the nucleolus under stress conditions
chrXVI	514510	517018	514510	517018	-	VTC3	YPL019C		514510,	517018,	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
chrXVI	517650	518760	517650	518760	+	CTF19	YPL018W		517650,	518760,	Outer kinetochore protein, required for accurate mitotic chromosome segregation  component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
chrXVI	518733	520233	518733	520233	-	IRC15	YPL017C		518733,	520233,	Microtubule associated protein  regulates microtubule dynamics  required for accurate meiotic chromosome segregation  null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
chrXVI	521013	524958	521013	524958	+	SWI1	YPL016W		521013,	524958,	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes  required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2  can form the prion [SWI+]
chrXVI	525809	526883	525809	526883	-	HST2	YPL015C		525809,	526883,	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases  modulates nucleolar (rDNA) and telomeric silencing  possesses NAD(+)-dependent histone deacetylase activity in vitro
chrXVI	527546	528692	527546	528692	+	YPL014W	YPL014W		527546,	528692,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
chrXVI	528984	529350	528984	529350	-	MRPS16	YPL013C		528984,	529350,	Mitochondrial ribosomal protein of the small subunit
chrXVI	529722	533409	529722	533409	+	RRP12	YPL012W		529722,	533409,	Protein required for export of the ribosomal subunits  associates with the RNA components of the pre-ribosomes  has a role in nuclear import in association with Pse1p  contains HEAT-repeats
chrXVI	533641	534703	533641	534703	-	TAF3	YPL011C		533641,	534703,	TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
chrXVI	535017	535587	535017	535587	+	RET3	YPL010W		535017,	535587,	Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles  involved in retrograde transport between Golgi and ER
chrXVI	535819	538936	535819	538936	-	TAE2	YPL009C		535819,	538936,	Protein of unknown function, involved in protein translation  may interact with ribosomes, based on co-purification experiments  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXVI	539384	541970	539384	541970	+	CHL1	YPL008W		539384,	541970,	Probable DNA helicase involved in sister-chromatid cohesion and genome integrity  interacts with ECO1 and CTF18  mutants are defective in silencing, rDNA recombination, aging and the heat shock response  FANCJ-like helicase family member
chrXVI	542081	543848	542081	543848	-	TFC8	YPL007C		542081,	543848,	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC)  part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes  linker between TauB and TauA domains  human homolog is TFIIIC-90
chrXVI	544630	548143	544630	548143	+	NCR1	YPL006W		544630,	548143,	Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism  glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
chrXVI	548485	550306	548485	550306	+	AEP3	YPL005W		548485,	550306,	Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation  localized to the matrix face of the mitochondrial inner membrane  stabilizes the bicistronic AAP1-ATP6 mRNA
chrXVI	550631	551657	550631	551657	-	LSP1	YPL004C		550631,	551657,	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p  null mutants show activation of Pkc1p/Ypk1p stress resistance pathways  member of the BAR domain family
chrXVI	552019	553408	552019	553408	+	ULA1	YPL003W		552019,	553408,	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
chrXVI	553626	554328	553626	554328	-	SNF8	YPL002C		553626,	554328,	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome  appears to be functionally related to SNF7  involved in glucose derepression
chrXVI	554604	555729	554604	555729	+	HAT1	YPL001W		554604,	555729,	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4  involved in telomeric silencing and DNA double-strand break repair
chrXVI	556376	557837	556376	557837	+	CIT3	YPR001W		556376,	557837,	Dual specificity mitochondrial citrate and methylcitrate synthase  catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
chrXVI	558384	559935	558384	559935	+	PDH1	YPR002W		558384,	559935,	Mitochondrial protein that participates in respiration, induced by diauxic shift  homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
chrXVI	560568	560766	560568	560766	-	YPR002C-A	YPR002C-A		560568,	560766,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  completely overlaps the Ty1 long terminal repeat, YPRWdelta12
chrXVI	561503	563768	561503	563768	-	YPR003C	YPR003C		561503,	563768,	Putative sulfate permease  physically interacts with Hsp82p  green fluorescent protein (GFP)-fusion protein localizes to the ER  YPR003C is not an essential gene
chrXVI	564006	565041	564006	565041	-	AIM45	YPR004C		564006,	565041,	Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha  interacts with frataxin, Yfh1p  null mutant displays elevated frequency of mitochondrial genome loss  may have a role in oxidative stress response
chrXVI	565786	566671	565786	566671	-	HAL1	YPR005C		565786,	566671,	Cytoplasmic protein involved in halotolerance  decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux  expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
chrXVI	567268	568996	567268	568996	-	ICL2	YPR006C		567268,	568996,	2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate  ICL2 transcription is repressed by glucose and induced by ethanol
chrXVI	569335	571378	569335	571378	-	REC8	YPR007C		569335,	571378,	Meiosis-specific component of sister chromatid cohesion complex  maintains cohesion between sister chromatids during meiosis I  maintains cohesion between centromeres of sister chromatids until meiosis II  homolog of S. pombe Rec8p
chrXVI	573017	575102	573017	575102	+	HAA1	YPR008W		573017,	575102,	Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins  involved in adaptation to weak acid stress
chrXVI	576551	577358	576551	577358	+	SUT2	YPR009W		576551,	577358,	Putative transcription factor  multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway  highly similar to Sut1p
chrXVI	577584	581196	577584	581196	-	RPA135	YPR010C		577584,	581196,	RNA polymerase I second largest subunit A135
chrXVI	582372	582734	582372	582734	-	YPR010C-A	YPR010C-A		582372,582701,	582558,582734,	Putative protein of unknown function  conserved among Saccharomyces sensu stricto species
chrXVI	583061	584042	583061	584042	-	YPR011C	YPR011C		583061,	584042,	Putative transporter, member of the mitochondrial carrier family  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXVI	584308	584563	584308	584563	+	YPR012W	YPR012W		584308,	584563,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YPR012W is not an essential gene
chrXVI	584631	585585	584631	585585	-	YPR013C	YPR013C		584631,	585585,	Putative zinc finger protein  YPR013C is not an essential gene
chrXVI	587188	587518	587188	587518	-	YPR014C	YPR014C		587188,	587518,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  YPR014C is not an essential gene
chrXVI	590282	591026	590282	591026	-	YPR015C	YPR015C		590282,	591026,	Putative protein of unknown function  overexpression causes a cell cycle delay or arrest
chrXVI	592331	593069	592331	593069	-	TIF6	YPR016C		592331,	593069,	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6)  may be involved in the biogenesis and or stability of 60S ribosomal subunits
chrXVI	593095	593356	593095	593356	+	YPR016W-A	YPR016W-A		593095,	593356,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXVI	593485	593917	593485	593917	-	DSS4	YPR017C		593485,	593917,	Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway  binds zinc, found both on membranes and in the cytosol
chrXVI	594475	596296	594475	596296	+	RLF2	YPR018W		594475,	596296,	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA  involved in the maintenance of transcriptionally silent chromatin
chrXVI	596749	599551	596749	599551	+	MCM4	YPR019W		596749,	599551,	Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication  forms an Mcm4p-6p-7p subcomplex  shows nuclear accumulation in G1  homolog of S. pombe Cdc21p
chrXVI	599869	600217	599869	600217	+	ATP20	YPR020W		599869,	600217,	Subunit g of the mitochondrial F1F0 ATP synthase  reversibly phosphorylated on two residues  unphosphorylated form is required for dimerization of the ATP synthase complex
chrXVI	600648	603357	600648	603357	-	AGC1	YPR021C		600648,	603357,	Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger  involved in nitrogen metabolism and nitrogen compound biosynthesis
chrXVI	603910	607312	603910	607312	-	YPR022C	YPR022C		603910,	607312,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
chrXVI	608825	610031	608825	610031	-	EAF3	YPR023C		608825,	610031,	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3  plays a role in regulating Ty1 transposition
chrXVI	610480	612724	610480	612724	+	YME1	YPR024W		610480,	612724,	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products  mutation causes an elevated rate of mitochondrial turnover
chrXVI	613376	614558	613376	614558	-	CCL1	YPR025C		613376,	614558,	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
chrXVI	615378	619014	615378	619014	+	ATH1	YPR026W		615378,	619014,	Acid trehalase required for utilization of extracellular trehalose
chrXVI	620424	621258	620424	621258	-	YPR027C	YPR027C		620424,	621258,	Putative protein of unknown function
chrXVI	623526	624202	623526	624202	+	YOP1	YPR028W		623526,623710,	623577,624202,	Membrane protein that interacts with Yip1p to mediate membrane traffic  interacts with Sey1p to maintain ER morphology  overexpression leads to cell death and accumulation of internal cell membranes
chrXVI	624468	626967	624468	626967	-	APL4	YPR029C		624468,	626967,	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex  binds clathrin  involved in vesicle mediated transport
chrXVI	627879	631245	627879	631245	+	CSR2	YPR030W		627879,	631245,	Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins  overproduction suppresses chs5 spa2 lethality at high temp  ubiquitinated by Rsp5p, deubiquitinated by Ubp2p
chrXVI	631514	633761	631514	633761	+	NTO1	YPR031W		631514,	633761,	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3  contains PHD finger domain that interacts with methylated histone H3
chrXVI	634122	637224	634122	637224	+	SRO7	YPR032W		634122,	637224,	Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p  involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane  homolog of Sro77p and Drosophila lgl tumor suppressor
chrXVI	637378	639019	637378	639019	-	HTS1	YPR033C		637378,	639019,	Cytoplasmic and mitochondrial histidine tRNA synthetase  efficient mitochondrial localization requires both a presequence and an amino-terminal sequence  mutations in human ortholog HARS2 are associated with Perrault syndrome
chrXVI	639524	640958	639524	640958	+	ARP7	YPR034W		639524,	640958,	Component of both the SWI/SNF and RSC chromatin remodeling complexes  actin-related protein involved in transcriptional regulation
chrXVI	642207	643320	642207	643320	+	GLN1	YPR035W		642207,	643320,	Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia  with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia  expression regulated by nitrogen source and by amino acid limitation
chrXVI	643835	645272	643835	645272	+	VMA13	YPR036W		643835,	645272,	Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system  serves as an activator or a structural stabilizer of the V-ATPase
chrXVI	645949	646153	645949	646153	+	YPR036W-A	YPR036W-A		645949,	646153,	Protein of unknown function  transcription is regulated by Pdr1p
chrXVI	646447	647038	646447	647038	-	ERV2	YPR037C		646447,	647038,	Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
chrXVI	646835	647195	646835	647195	+	IRC16	YPR038W		646835,	647195,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene YPR037C  null mutant displays increased levels of spontaneous Rad52p foci
chrXVI	647011	647347	647011	647347	+	YPR039W	YPR039W		647011,	647347,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
chrXVI	647304	648375	647304	648375	+	TIP41	YPR040W		647304,	648375,	Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A  component of the TOR (target of rapamycin) signaling pathway
chrXVI	648703	649921	648703	649921	+	TIF5	YPR041W		648703,	649921,	Translation initiation factor eIF5  functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
chrXVI	650434	653662	650434	653662	-	PUF2	YPR042C		650434,	653662,	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity  preferentially binds mRNAs encoding membrane-associated proteins
chrXVI	654165	654847	654165	654847	+	RPL43A	YPR043W		654165,654570,	654167,654847,	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein  null mutation confers a dominant lethal phenotype
chrXVI	654523	654877	654523	654877	-	OPI11	YPR044C		654523,	654877,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene RPL43A/YPR043W  deletion confers sensitivity to GSAO
chrXVI	655139	656552	655139	656552	-	THP3	YPR045C		655139,	656552,	Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation  possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
chrXVI	656798	657344	656798	657344	+	MCM16	YPR046W		656798,	657344,	Protein involved in kinetochore-microtubule mediated chromosome segregation  binds to centromere DNA
chrXVI	657528	658938	657528	658938	+	MSF1	YPR047W		657528,	658938,	Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer  similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase
chrXVI	659181	661053	659181	661053	+	TAH18	YPR048W		659181,	661053,	Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery  transfers electrons from NADPH to the Fe-S cluster of Dre2p  plays a pro-death role under oxidative stress
chrXVI	661136	664673	661136	664673	-	ATG11	YPR049C		661136,	664673,	Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway  directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles  required for recruiting other proteins to the (PAS)
chrXVI	664952	665366	664952	665366	-	YPR050C	YPR050C		664952,	665366,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene MAK3/YPR051W
chrXVI	664959	665490	664959	665490	+	MAK3	YPR051W		664959,	665490,	Catalytic subunit of N-terminal acetyltransferase of the NatC type  required for replication of dsRNA virus
chrXVI	665692	665974	665692	665974	-	NHP6A	YPR052C		665692,	665974,	High-mobility group (HMG) protein that binds to and remodels nucleosomes  involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes  functionally redundant with Nhp6Bp  homologous to mammalian HMGB1 and HMGB2
chrXVI	665787	666243	665787	666243	-	YPR053C	YPR053C		665787,	666243,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified gene NHP6A/YPR052C
chrXVI	666279	667446	666279	667446	+	SMK1	YPR054W		666279,	667446,	Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers  negatively regulates activity of the glucan synthase subunit Gsc2p
chrXVI	667675	670873	667675	670873	+	SEC8	YPR055W		667675,	670873,	Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
chrXVI	671125	672142	671125	672142	+	TFB4	YPR056W		671125,	672142,	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH  interacts with Ssl1p
chrXVI	672470	673496	672470	673496	+	BRR1	YPR057W		672470,	673496,	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis  in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed
chrXVI	673750	674674	673750	674674	+	YMC1	YPR058W		673750,	674674,	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis  member of the mitochondrial carrier (MCF) family  has similarity with Ymc2p
chrXVI	674313	674700	674313	674700	-	YPR059C	YPR059C		674313,	674700,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene YMC1/YPR058W
chrXVI	674860	675631	674860	675631	-	ARO7	YPR060C		674860,	675631,	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
chrXVI	675976	676882	675976	676882	-	JID1	YPR061C		675976,	676882,	Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain  inhibits replication of Brome mosaic virus in S. cerevisiae
chrXVI	677164	677641	677164	677641	+	FCY1	YPR062W		677164,	677641,	Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil  of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
chrXVI	677811	678320	677811	678320	-	YPR063C	YPR063C		677811,678279,	678193,678320,	ER-localized protein of unknown function
chrXVI	678950	679370	678950	679370	+	YPR064W	YPR064W		678950,	679370,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXVI	679692	680799	679692	680799	+	ROX1	YPR065W		679692,	680799,	Heme-dependent repressor of hypoxic genes  contains an HMG domain that is responsible for DNA bending activity
chrXVI	681212	682112	681212	682112	+	UBA3	YPR066W		681212,	682112,	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation  GFP-fusion protein localizes to the cytoplasm in a punctate pattern
chrXVI	682219	682777	682219	682777	+	ISA2	YPR067W		682219,	682777,	Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
chrXVI	682940	684353	682940	684353	-	HOS1	YPR068C		682940,	684353,	Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset  has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p  interacts with the Tup1p-Ssn6p corepressor complex
chrXVI	684555	685437	684555	685437	-	SPE3	YPR069C		684555,	685437,	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid  spermidine is required for growth of wild-type cells
chrXVI	685897	687598	685897	687598	+	MED1	YPR070W		685897,	687598,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  essential for transcriptional regulation
chrXVI	688171	688807	688171	688807	+	YPR071W	YPR071W		688171,	688807,	Putative membrane protein  YPR071W is not an essential gene
chrXVI	690106	691789	690106	691789	+	NOT5	YPR072W		690106,	691789,	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
chrXVI	691932	692418	691932	692418	-	LTP1	YPR073C		691932,	692418,	Protein phosphotyrosine phosphatase of unknown cellular role  activated by adenine
chrXVI	692795	694838	692795	694838	-	TKL1	YPR074C		692795,	694838,	Transketolase, similar to Tkl2p  catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway  needed for synthesis of aromatic amino acids
chrXVI	695017	695188	695017	695188	+	YPR074W-A	YPR074W-A		695017,	695188,	Hypothetical protein identified by homology
chrXVI	695736	696819	695736	696819	-	OPY2	YPR075C		695736,	696819,	Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway  interacts with Ste50p  overproduction blocks cell cycle arrest in the presence of mating pheromone
chrXVI	696475	696850	696475	696850	+	YPR076W	YPR076W		696475,	696850,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXVI	697130	697502	697130	697502	-	YPR077C	YPR077C		697130,	697502,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  expression increased by deletion of NAP1
chrXVI	697146	698265	697146	698265	-	YPR078C	YPR078C		697146,	698265,	Putative protein of unknown function  possible role in DNA metabolism and/or in genome stability  expression is heat-inducible
chrXVI	698868	700014	698868	700014	+	MRL1	YPR079W		698868,	700014,	Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases
chrXVI	700593	701970	700593	701970	+	TEF1	YPR080W		700593,	701970,	Translational elongation factor EF-1 alpha  also encoded by TEF2  functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes  may also have a role in tRNA re-export from the nucleus
chrXVI	702113	703970	702113	703970	-	GRS2	YPR081C		702113,	703970,	Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase  cannot substitute for Grs1p  possible pseudogene that is expressed at very low levels
chrXVI	704224	704656	704224	704656	-	DIB1	YPR082C		704224,	704656,	17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
chrXVI	704853	706593	704853	706593	+	MDM36	YPR083W		704853,	706593,	Mitochondrial protein required for normal mitochondrial morphology and inheritance  proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission
chrXVI	706971	708342	706971	708342	+	YPR084W	YPR084W		706971,	708342,	Putative protein of unknown function
chrXVI	708496	709828	708496	709828	-	ASA1	YPR085C		708496,	709828,	Putative protein of unknown function  subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery
chrXVI	710100	711138	710100	711138	+	SUA7	YPR086W		710100,	711138,	Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
chrXVI	711353	711674	711353	711674	+	VPS69	YPR087W		711353,	711674,	Dubious open reading frame, unlikely to encode a protein  not conserved in closely related Saccharomyces species  85% of ORF overlaps the verified gene SRP54  deletion causes a vacuolar protein sorting defect
chrXVI	711402	713028	711402	713028	-	SRP54	YPR088C		711402,	713028,	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54)  contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor  contains GTPase domain
chrXVI	713274	715941	713274	715941	+	YPR089W	YPR089W		713274,	715941,	Protein of unknown function  exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
chrXVI	716155	718468	716155	718468	-	YPR091C	YPR091C		716155,	718468,	Putative protein of unknown function  may interact with ribosomes, based on co-purification experiments  GFP-fusion protein localizes to the ER  contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
chrXVI	718378	718684	718378	718684	+	YPR092W	YPR092W		718378,	718684,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXVI	719557	720424	719557	720424	-	ASR1	YPR093C		719557,	720424,	Ubiquitin ligase that modifies and regulates RNA Pol II  involved in a putative alcohol-responsive signaling pathway  accumulates in the nucleus under alcohol stress  contains a Ring/PHD finger domain similar to the mammalian rA9 protein
chrXVI	720636	720960	720636	720960	+	RDS3	YPR094W		720636,	720960,	Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
chrXVI	721036	724717	721036	724717	-	SYT1	YPR095C		721036,	724717,	Guanine nucleotide exchange factor (GEF) for Arf proteins  promotes activation of Arl1p, which recruits Imh1p to the Golgi  involved in vesicular transport  member of the Sec7-domain family  contains a PH domain
chrXVI	724841	725144	724841	725144	-	YPR096C	YPR096C		724841,	725144,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
chrXVI	725393	728615	725393	728615	+	YPR097W	YPR097W		725393,	728615,	Protein that contains a Phox homology (PX) domain and binds phosphoinositides  the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
chrXVI	728946	729528	728946	729528	-	YPR098C	YPR098C		728946,729481,	729385,729528,	Protein of unknown function, localized to the mitochondrial outer membrane
chrXVI	729756	730113	729756	730113	-	YPR099C	YPR099C		729756,	730113,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene MRPL51/YPR100W
chrXVI	729790	730213	729790	730213	+	MRPL51	YPR100W		729790,	730213,	Mitochondrial ribosomal protein of the large subunit
chrXVI	730491	731019	730491	731019	+	SNT309	YPR101W		730491,	731019,	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs  interacts physically and genetically with Prp19p
chrXVI	731223	731748	731223	731748	-	RPL11A	YPR102C		731223,	731748,	Protein of the large 60S ribosomal subunit, nearly identical to Rpl11Bp but expressed at twice the level  involved in ribosomal assembly  depletion causes degradation of 60S proteins and RNA  similar to E. coli L5 and rat L11
chrXVI	732348	733212	732348	733212	+	PRE2	YPR103W		732348,	733212,	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
chrXVI	733622	736433	733622	736433	-	FHL1	YPR104C		733622,	736433,	Regulator of ribosomal protein transcription  has forkhead associated domain that binds phosphorylated proteins  also has forkhead DNA-binding domain but does not bind DNA in vitro  suppresses RNA pol III and splicing factor prp4 mutants
chrXVI	736983	739569	736983	739569	-	COG4	YPR105C		736983,	739569,	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
chrXVI	740060	741392	740060	741392	+	ISR1	YPR106W		740060,	741392,	Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
chrXVI	741437	742064	741437	742064	-	YTH1	YPR107C		741437,	742064,	Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers  required for pre-mRNA 3'-end processing and polyadenylation
chrXVI	742453	743743	742453	743743	+	RPN7	YPR108W		742453,	743743,	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
chrXVI	744174	744387	744174	744387	+	YPR108W-A	YPR108W-A		744174,	744387,	Putative protein of unknown function  identified by fungal homology and RT-PCR
chrXVI	744688	745573	744688	745573	+	YPR109W	YPR109W		744688,	745573,	Predicted membrane protein  dipoid deletion strain has high budding index
chrXVI	745827	746835	745827	746835	-	RPC40	YPR110C		745827,	746835,	RNA polymerase subunit AC40, common to RNA polymerase I and III
chrXVI	747305	749000	747305	749000	+	DBF20	YPR111W		747305,	749000,	Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins  necessary for the execution of cytokinesis
chrXVI	749255	751919	749255	751919	-	MRD1	YPR112C		749255,	751919,	Essential conserved protein that is part of the 90S preribosome  required for production of 18S rRNA and small ribosomal subunit  contains five consensus RNA-binding domains
chrXVI	752256	752919	752256	752919	+	PIS1	YPR113W		752256,	752919,	Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
chrXVI	753300	754248	753300	754248	+	YPR114W	YPR114W		753300,	754248,	Putative protein of unknown function
chrXVI	754876	758128	754876	758128	+	RGC1	YPR115W		754876,	758128,	Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator  paralogous to Ask10p  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
chrXVI	758647	759481	758647	759481	+	RRG8	YPR116W		758647,	759481,	Putative protein of unknown function, required for mitochondrial genome maintenance  null mutation results in a decrease in plasma membrane electron transport
chrXVI	760024	767494	760024	767494	+	YPR117W	YPR117W		760024,	767494,	Putative protein of unknown function
chrXVI	767751	768987	767751	768987	+	MRI1	YPR118W		767751,	768987,	5'-methylthioribose-1-phosphate isomerase  catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
chrXVI	771652	773128	771652	773128	+	CLB2	YPR119W		771652,	773128,	B-type cyclin involved in cell cycle progression  activates Cdc28p to promote the transition from G2 to M phase  accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
chrXVI	773874	775182	773874	775182	-	CLB5	YPR120C		773874,	775182,	B-type cyclin involved in DNA replication during S phase  activates Cdc28p to promote initiation of DNA synthesis  functions in formation of mitotic spindles along with Clb3p and Clb4p  most abundant during late G1 phase
chrXVI	778582	780301	778582	780301	+	THI22	YPR121W		778582,	780301,	Protein with similarity to hydroxymethylpyrimidine phosphate kinases  member of a gene family with THI20 and THI21  not required for thiamine biosynthesis
chrXVI	782044	785671	782044	785671	+	AXL1	YPR122W		782044,	785671,	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone  required for axial budding pattern of haploid cells
chrXVI	786140	786575	786140	786575	-	YPR123C	YPR123C		786140,	786575,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially/completely overlaps the verified ORF CTR
chrXVI	786207	787428	786207	787428	+	CTR1	YPR124W		786207,	787428,	High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions  transcriptionally induced at low copper levels and degraded at high copper levels
chrXVI	787960	789325	787960	789325	+	YLH47	YPR125W		787960,	789325,	Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth  homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
chrXVI	789076	789385	789076	789385	-	YPR126C	YPR126C		789076,	789385,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXVI	790082	791120	790082	791120	+	YPR127W	YPR127W		790082,	791120,	Protein of unknown function, differentially expressed during alcoholic fermentation  expression activated by transcription factor YRM1/YOR172W  green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
chrXVI	791217	792204	791217	792204	-	ANT1	YPR128C		791217,	792204,	Peroxisomal adenine nucleotide transporter  involved in beta-oxidation of medium-chain fatty acid  required for peroxisome proliferation
chrXVI	792686	793736	792686	793736	+	SCD6	YPR129W		792686,	793736,	Protein containing an Lsm domain  negatively regulates translation initiation via 48S preinitiation complex assembly  may bind RNA and have a role in RNA processing  overproduction suppresses null mutation in clathrin heavy chain gene CHC1
chrXVI	793373	793781	793373	793781	-	YPR130C	YPR130C		793373,	793781,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXVI	793910	794498	793910	794498	-	NAT3	YPR131C		793910,	794498,	Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
chrXVI	794964	795767	794964	795767	+	RPS23B	YPR132W		794964,795394,	795029,795767,	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy  nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins  deletion of both RPS23A and RPS23B is lethal
chrXVI	795977	797210	795977	797210	-	SPN1	YPR133C		795977,	797210,	Protein involved in RNA polymerase II transcription  interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors  central domain highly conserved throughout eukaryotes  mutations confer an Spt- phenotype
chrXVI	797556	797709	797556	797709	+	TOM5	YPR133W-A		797556,	797709,	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins  involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
chrXVI	798050	798857	798050	798857	+	MSS18	YPR134W		798050,	798857,	Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron  mss18 mutations block cleavage of 5' exon - intron junction  phenotype of intronless strain suggests additional functions
chrXVI	799233	802017	799233	802017	+	CTF4	YPR135W		799233,	802017,	Chromatin-associated protein, required for sister chromatid cohesion  interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
chrXVI	802324	802837	802324	802837	-	YPR136C	YPR136C		802324,	802837,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps verified ORF RRP9
chrXVI	802358	804080	802358	804080	+	RRP9	YPR137W		802358,	804080,	Protein involved in pre-rRNA processing, associated with U3 snRNP  component of small ribosomal subunit (SSU) processosome  ortholog of the human U3-55k protein
chrXVI	805000	810269	805000	810269	-	YPR137C-B	YPR137C-B		805000,808964,	808963,810269,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXVI	808946	810269	808946	810269	-	YPR137C-A	YPR137C-A		808946,	810269,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXVI	810983	812453	810983	812453	-	MEP3	YPR138C		810983,	812453,	Ammonium permease of high capacity and low affinity  belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+)  expression is under the nitrogen catabolite repression regulation ammonia permease
chrXVI	813155	814058	813155	814058	-	VPS66	YPR139C		813155,	814058,	Cytoplasmic protein of unknown function involved in vacuolar protein sorting
chrXVI	814390	815536	814390	815536	+	TAZ1	YPR140W		814390,	815536,	Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes  may remodel acyl groups of cardiolipin in the inner membrane  human ortholog tafazzin is implicated in Barth syndrome
chrXVI	815733	817923	815733	817923	-	KAR3	YPR141C		815733,	817923,	Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating  potential Cdc28p substrate
chrXVI	818129	818693	818129	818693	-	YPR142C	YPR142C		818129,	818693,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
chrXVI	818322	819075	818322	819075	+	RRP15	YPR143W		818322,	819075,	Nucleolar protein, constituent of pre-60S ribosomal particles  required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
chrXVI	819764	821423	819764	821423	-	NOC4	YPR144C		819764,	821423,	Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
chrXVI	822619	824338	822619	824338	+	ASN1	YPR145W		822619,	824338,	Asparagine synthetase, isozyme of Asn2p  catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
chrXVI	824689	824926	824689	824926	-	YPR145C-A	YPR145C-A		824689,	824926,	Putative protein of unknown function
chrXVI	825346	825676	825346	825676	-	YPR146C	YPR146C		825346,	825676,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXVI	825644	826559	825644	826559	-	YPR147C	YPR147C		825644,	826559,	Putative protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
chrXVI	826832	828140	826832	828140	-	YPR148C	YPR148C		826832,	828140,	Protein of unknown function that may interact with ribosomes, based on co-purification experiments  green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
chrXVI	829917	830439	829917	830439	+	NCE102	YPR149W		829917,	830439,	Protein of unknown function  contains transmembrane domains  involved in secretion of proteins that lack classical secretory signal sequences  component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
chrXVI	830998	831520	830998	831520	+	YPR150W	YPR150W		830998,	831520,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the verified gene SUE1/YPR151C
chrXVI	831054	831675	831054	831675	-	SUE1	YPR151C		831054,	831675,	Mitochondrial protein required for degradation of unstable forms of cytochrome c
chrXVI	832060	833458	832060	833458	-	URN1	YPR152C		832060,	833458,	Putative protein of unknown function containing WW and FF domains  overexpression causes accumulation of cells in G1 phase
chrXVI	833688	834245	833688	834245	+	YPR153W	YPR153W		833688,833827,	833693,834245,	Putative protein of unknown function
chrXVI	834564	835212	834564	835212	+	PIN3	YPR154W		834564,	835212,	Protein that induces appearance of [PIN+] prion when overproduced
chrXVI	835562	837413	835562	837413	-	NCA2	YPR155C		835562,	837413,	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase  functions with Nca3p
chrXVI	837908	839777	837908	839777	-	TPO3	YPR156C		837908,	839777,	Polyamine transport protein specific for spermine  localizes to the plasma membrane  member of the major facilitator superfamily
chrXVI	841265	842669	841265	842669	+	YPR157W	YPR157W		841265,	842669,	Putative protein of unknown function  induced by treatment with 8-methoxypsoralen and UVA irradiation  null mutant is sensitive to expression of the top1-T722A allele
chrXVI	843261	844020	843261	844020	+	CUR1	YPR158W		843261,	844020,	Protein of unknown function involved in destabilization of [URE3] prions  similar in sequence to Btn2p
chrXVI	844708	849980	844708	849980	+	YPR158W-B	YPR158W-B		844708,846014,	846013,849980,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXVI	844708	846031	844708	846031	+	YPR158W-A	YPR158W-A		844708,	846031,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXVI	850988	856257	850988	856257	-	YPR158C-D	YPR158C-D		850988,854952,	854951,856257,	Retrotransposon TYA Gag and TYB Pol genes  transcribed/translated as one unit  polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN)  similar to retroviral genes
chrXVI	854934	856257	854934	856257	-	YPR158C-C	YPR158C-C		854934,	856257,	Retrotransposon TYA Gag gene co-transcribed with TYB Pol  translated as TYA or TYA-TYB polyprotein  Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs)  similar to retroviral Gag
chrXVI	857582	859745	857582	859745	+	KRE6	YPR159W		857582,	859745,	Type II integral membrane protein required for beta-1,6 glucan biosynthesis  putative beta-glucan synthase  localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles  functionally redundant with Skn1p
chrXVI	860313	860415	860313	860415	-	YPR159C-A	YPR159C-A		860313,	860415,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	861305	864014	861305	864014	+	GPH1	YPR160W		861305,	864014,	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
chrXVI	861933	862014	861933	862014	+	YPR160W-A	YPR160W-A		861933,	862014,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  identified by expression profiling and mass spectrometry
chrXVI	862576	862861	862576	862861	-	YPR160C-A	YPR160C-A		862576,	862861,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
chrXVI	864448	866422	864448	866422	-	SGV1	YPR161C		864448,	866422,	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation  phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p  regulated by Cak1p  similar to metazoan CDK9 proteins
chrXVI	866714	868304	866714	868304	-	ORC4	YPR162C		866714,	868304,	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
chrXVI	868644	869955	868644	869955	-	TIF3	YPR163C		868644,	869955,	Translation initiation factor eIF-4B, has RNA annealing activity  contains an RNA recognition motif and binds to single-stranded RNA
chrXVI	870702	874926	870702	874926	+	MMS1	YPR164W		870702,	874926,	Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks  regulates Ty1 transposition  involved with Rtt101p in nonfunctional rRNA decay
chrXVI	875367	875997	875367	875997	+	RHO1	YPR165W		875367,	875997,	GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity  regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
chrXVI	876281	876629	876281	876629	-	MRP2	YPR166C		876281,	876629,	Mitochondrial ribosomal protein of the small subunit
chrXVI	876846	877632	876846	877632	-	MET16	YPR167C		876846,	877632,	3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
chrXVI	878075	878549	878075	878549	+	NUT2	YPR168W		878075,	878549,	Subunit of the RNA polymerase II mediator complex  associates with core polymerase subunits to form the RNA polymerase II holoenzyme  required for transcriptional activation and has a role in basal transcription
chrXVI	878689	880168	878689	880168	+	JIP5	YPR169W		878689,	880168,	Essential protein required for biogenesis of the large ribosomal subunit  interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation  similar to WDR55, a human WD repeat protein
chrXVI	882982	883318	882982	883318	-	YPR170C	YPR170C		882982,	883318,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
chrXVI	883238	883595	883238	883595	+	YPR170W-B	YPR170W-B		883238,883486,	883387,883595,	Putative protein of unknown function, conserved in fungi  partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
chrXVI	883238	883457	883238	883457	+	YPR169W-A	YPR169W-A		883238,	883457,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
chrXVI	883377	883563	883377	883563	+	YPR170W-A	YPR170W-A		883377,	883563,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data  identified by expression profiling and mass spectrometry
chrXVI	883827	885558	883827	885558	+	BSP1	YPR171W		883827,	885558,	Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
chrXVI	885795	886398	885795	886398	+	YPR172W	YPR172W		885795,	886398,	Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
chrXVI	886523	887837	886523	887837	-	VPS4	YPR173C		886523,	887837,	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release  ATPase activity is activated by Vta1p  regulates cellular sterol metabolism
chrXVI	888042	888708	888042	888708	-	YPR174C	YPR174C		888042,	888708,	Protein of unknown function  green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery  potential Cdc28p substrate  binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study
chrXVI	888973	891043	888973	891043	+	DPB2	YPR175W		888973,	891043,	Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication  expression peaks at the G1/S phase boundary  potential Cdc28p substrate
chrXVI	891100	892078	891100	892078	-	BET2	YPR176C		891100,	892078,	Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi  provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
chrXVI	892312	892684	892312	892684	-	YPR177C	YPR177C		892312,	892684,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data  partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
chrXVI	892331	893729	892331	893729	+	PRP4	YPR178W		892331,	893729,	Splicing factor, component of the U4/U6-U5 snRNP complex
chrXVI	893796	895764	893796	895764	-	HDA3	YPR179C		893796,	895764,	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer  required for the activity of the complex  has similarity to Hda2p
chrXVI	895960	897004	895960	897004	+	AOS1	YPR180W		895960,	897004,	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p  activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting  essential for viability
chrXVI	897360	899667	897360	899667	-	SEC23	YPR181C		897360,	899667,	GTPase-activating protein, stimulates the GTPase activity of Sar1p  component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport
chrXVI	900193	900454	900193	900454	+	SMX3	YPR182W		900193,	900454,	Core Sm protein Sm F  part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs  homolog of human Sm F
chrXVI	900754	901558	900754	901558	+	DPM1	YPR183W		900754,	901558,	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man  required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
chrXVI	902043	906654	902043	906654	+	GDB1	YPR184W		902043,	906654,	Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation  phosphorylated in mitochondria  activity is inhibited by Igd1p
chrXVI	907217	909434	907217	909434	+	ATG13	YPR185W		907217,	909434,	Regulatory subunit of the Atg1p signaling complex  stimulates Atg1p kinase activity  required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway  involved in Atg9p, Atg23p, and Atg27p cycling
chrXVI	909732	911022	909732	911022	-	PZF1	YPR186C		909732,	911022,	Transcription factor IIIA (TFIIIA)  essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III  not involved in transcription of other RNAP III genes  nine conserved zinc fingers  may also bind 5S rRNA
chrXVI	911256	911800	911256	911800	+	RPO26	YPR187W		911256,911352,	911276,911800,	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III  part of central core  similar to bacterial omega subunit
chrXVI	911987	912479	911987	912479	-	MLC2	YPR188C		911987,	912479,	Regulatory light chain for the type II myosin, Myo1p  binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p  involved in the disassembly of the Myo1p ring
chrXVI	912663	916962	912663	916962	+	SKI3	YPR189W		912663,	916962,	Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome  null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
chrXVI	917076	919041	917076	919041	-	RPC82	YPR190C		917076,	919041,	RNA polymerase III subunit C82
chrXVI	919380	920487	919380	920487	+	QCR2	YPR191W		919380,	920487,	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain  phosphorylated  transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
chrXVI	921859	922777	921859	922777	+	AQY1	YPR192W		921859,	922777,	Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled  may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
chrXVI	922908	923379	922908	923379	-	HPA2	YPR193C		922908,	923379,	Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p  acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
chrXVI	924303	926937	924303	926937	-	OPT2	YPR194C		924303,	926937,	Oligopeptide transporter  member of the OPT family, with potential orthologs in S. pombe and C. albicans  also plays a role in formation of mature vacuoles
chrXVI	927964	928294	927964	928294	-	YPR195C	YPR195C		927964,	928294,	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
chrXVI	931375	932788	931375	932788	+	YPR196W	YPR196W		931375,	932788,	Putative maltose activator
chrXVI	933897	934461	933897	934461	-	YPR197C	YPR197C		933897,	934461,	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
chrXVI	934033	935665	934033	935665	+	SGE1	YPR198W		934033,	935665,	Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease  partial multicopy suppressor of gal11 mutations
chrXVI	938147	939032	938147	939032	-	ARR1	YPR199C		938147,	939032,	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
chrXVI	939278	939671	939278	939671	-	ARR2	YPR200C		939278,	939671,	Arsenate reductase required for arsenate resistance  converts arsenate to arsenite which can then be exported from cells by Arr3p
chrXVI	939921	941136	939921	941136	+	ARR3	YPR201W		939921,	941136,	Plasma membrane metalloid/H+ antiporter  transports arsenite and antimonite  required for resistance to arsenic compounds  transcription is activated by Arr1p in the presence of arsenite
chrXVI	943031	943896	943031	943896	+	YPR202W	YPR202W		943031,943198,	943050,943896,	Putative protein of unknown function with similarity to telomere-encoded helicases  YPR202W is not an essential gene  transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
chrXVI	943879	944188	943879	944188	+	YPR203W	YPR203W		943879,	944188,	Putative protein of unknown function
chrXVI	944602	947701	944602	947701	+	YPR204W	YPR204W		944602,	947701,	Helicase-like protein encoded within the telomeric Y' element
chrXVI	946855	947338	946855	947338	-	YPR204C-A	YPR204C-A		946855,	947338,	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
