# Table S10: GO terms enriched in the genes with highest DM scores in individual 18 (genotype NA18523) in LCLs. Enrichment performed using GORILLA. N - total number of genes, B - total number of genes associated with a specific GO term, n - number of genes in the top of the user's input list, b - number of genes in the intersection. GO Term Description P-value FDR q-value Enrichment N B n b Genes GO:0044085 cellular component biogenesis 3.97E-05 4.59E-01 3.56 6191 48 579 16 "[LTV1 - ltv1 homolog (s. cerevisiae), ZNF622 - zinc finger protein 622, RPS16 - ribosomal protein s16, GTF3A - general transcription factor iiia, CEBPZ - ccaat/enhancer binding protein (c/ebp), zeta, PEX11A - peroxisomal biogenesis factor 11 alpha, RPF2 - ribosome production factor 2 homolog (s. cerevisiae), PWP1 - pwp1 homolog (s. cerevisiae), BOP1 - block of proliferation 1, NIP7 - nip7, nucleolar pre-rrna processing protein, PAK1IP1 - pak1 interacting protein 1, ARRDC1 - arrestin domain containing 1, RPS28 - ribosomal protein s28, TGS1 - trimethylguanosine synthase 1, URB2 - urb2 ribosome biogenesis 2 homolog (s. cerevisiae), SURF6 - surfeit 6]" GO:0016070 RNA metabolic process 8.95E-05 5.18E-01 1.45 6191 797 649 121 "[EXOSC5 - exosome component 5, HSF1 - heat shock transcription factor 1, SYF2 - syf2 pre-mrna-splicing factor, HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PLD6 - phospholipase d family, member 6, DRAP1 - dr1-associated protein 1 (negative cofactor 2 alpha), BOP1 - block of proliferation 1, PCBP1 - poly(rc) binding protein 1, ZFP36L2 - zfp36 ring finger protein-like 2, GTF2A2 - general transcription factor iia, 2, 12kda, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), UTP20 - utp20, small subunit (ssu) processome component, homolog (yeast), GTF2A1 - general transcription factor iia, 1, 19/37kda, NELFB - negative elongation factor complex member b, GTF3A - general transcription factor iiia, RPUSD1 - rna pseudouridylate synthase domain containing 1, KTI12 - kti12 homolog, chromatin associated (s. cerevisiae), TAF6L - taf6-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, TP53RK - tp53 regulating kinase, ZC3H8 - zinc finger ccch-type containing 8, DCAF13 - ddb1 and cul4 associated factor 13, EXOSC6 - exosome component 6, USPL1 - ubiquitin specific peptidase like 1, CSTF2T - cleavage stimulation factor, 3' pre-rna, subunit 2, 64kda, tau variant, POLR3K - polymerase (rna) iii (dna directed) polypeptide k, 12.3 kda, WDR18 - wd repeat domain 18, NR1D1 - nuclear receptor subfamily 1, group d, member 1, TAF9 - taf9 rna polymerase ii, tata box binding protein (tbp)-associated factor, 32kda, SNRPB2 - small nuclear ribonucleoprotein polypeptide b, BMS1 - bms1 ribosome biogenesis factor, TAF7 - taf7 rna polymerase ii, tata box binding protein (tbp)-associated factor, 55kda, RPP21 - ribonuclease p/mrp 21kda subunit, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, TAF4B - taf4b rna polymerase ii, tata box binding protein (tbp)-associated factor, 105kda, SNRPE - small nuclear ribonucleoprotein polypeptide e, SNORA43 - small nucleolar rna, h/aca box 43, QTRT1 - queuine trna-ribosyltransferase 1, EIF4A3 - eukaryotic translation initiation factor 4a3, NABP2 - nucleic acid binding protein 2, HARS - histidyl-trna synthetase, BCDIN3D - bcdin3 domain containing, CTU1 - cytosolic thiouridylase subunit 1, TAF12 - taf12 rna polymerase ii, tata box binding protein (tbp)-associated factor, 20kda, TAF13 - taf13 rna polymerase ii, tata box binding protein (tbp)-associated factor, 18kda, RBM15B - rna binding motif protein 15b, BAZ2A - bromodomain adjacent to zinc finger domain, 2a, IMP4 - imp4, u3 small nucleolar ribonucleoprotein, homolog (yeast), SNORA9 - small nucleolar rna, h/aca box 9, CDK9 - cyclin-dependent kinase 9, LSM5 - lsm5 homolog, u6 small nuclear rna associated (s. cerevisiae), POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, CDK7 - cyclin-dependent kinase 7, LCMT2 - leucine carboxyl methyltransferase 2, LSM1 - lsm1 homolog, u6 small nuclear rna associated (s. cerevisiae), E2F1 - e2f transcription factor 1, SNORD60 - small nucleolar rna, c/d box 60, TSEN54 - tsen54 trna splicing endonuclease subunit, PWP1 - pwp1 homolog (s. cerevisiae), CTIF - cbp80/20-dependent translation initiation factor, NOP10 - nop10 ribonucleoprotein, MOCS3 - molybdenum cofactor synthesis 3, SNRNP25 - small nuclear ribonucleoprotein 25kda (u11/u12), ELAC1 - elac ribonuclease z 1, TCEANC2 - transcription elongation factor a (sii) n-terminal and central domain containing 2, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, YBEY - ybey metallopeptidase (putative), PARS2 - prolyl-trna synthetase 2, mitochondrial (putative), SNORD4A - small nucleolar rna, c/d box 4a, SNORD68 - small nucleolar rna, c/d box 68, WDR4 - wd repeat domain 4, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, C9orf156 - chromosome 9 open reading frame 156, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), TAF5L - taf5-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, RPL19 - ribosomal protein l19, ZBTB1 - zinc finger and btb domain containing 1, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), EAF1 - ell associated factor 1, RPF2 - ribosome production factor 2 homolog (s. cerevisiae), FAM207A - family with sequence similarity 207, member a, TFB2M - transcription factor b2, mitochondrial, SUPV3L1 - suppressor of var1, 3-like 1 (s. cerevisiae), SIRT7 - sirtuin 7, UBL5 - ubiquitin-like 5, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, MAZ - myc-associated zinc finger protein (purine-binding transcription factor), UTP3 - utp3, small subunit (ssu) processome component, homolog (s. cerevisiae), TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), MRPL12 - mitochondrial ribosomal protein l12, TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), FASTKD5 - fast kinase domains 5, DDX51 - dead (asp-glu-ala-asp) box polypeptide 51, ZCRB1 - zinc finger cchc-type and rna binding motif 1, RPL38 - ribosomal protein l38, AURKAIP1 - aurora kinase a interacting protein 1, RPL28 - ribosomal protein l28, SF3B14 - splicing factor 3b, 14 kda subunit, NPM3 - nucleophosmin/nucleoplasmin 3, JUN - jun proto-oncogene, RPS16 - ribosomal protein s16, RNASEK - ribonuclease, rnase k, RPS18 - ribosomal protein s18, TFDP1 - transcription factor dp-1, NFIL3 - nuclear factor, interleukin 3 regulated, C10orf2 - chromosome 10 open reading frame 2, XRN2 - 5'-3' exoribonuclease 2, TRPT1 - trna phosphotransferase 1, TGS1 - trimethylguanosine synthase 1, PHRF1 - phd and ring finger domains 1, KIAA0391 - kiaa0391, MTERF - mitochondrial transcription termination factor, U2AF2 - u2 small nuclear rna auxiliary factor 2, ZNF830 - zinc finger protein 830, TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), SFSWAP - splicing factor, suppressor of white-apricot homolog (drosophila), BRF2 - brf2, rna polymerase iii transcription initiation factor 50 kda subunit, EXOSC4 - exosome component 4, SNORD3A - small nucleolar rna, c/d box 3a, RPS28 - ribosomal protein s28, GTF3C4 - general transcription factor iiic, polypeptide 4, 90kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2]" GO:0043414 macromolecule methylation 1.55E-04 5.97E-01 2.34 6191 108 687 28 "[WDR4 - wd repeat domain 4, WDR82 - wd repeat domain 82, C9orf156 - chromosome 9 open reading frame 156, PLD6 - phospholipase d family, member 6, TFB2M - transcription factor b2, mitochondrial, BCDIN3D - bcdin3 domain containing, SIRT7 - sirtuin 7, TGS1 - trimethylguanosine synthase 1, WDR5B - wd repeat domain 5b, RBM15B - rna binding motif protein 15b, BAZ2A - bromodomain adjacent to zinc finger domain, 2a, SETD8 - set domain containing (lysine methyltransferase) 8, RLF - rearranged l-myc fusion, KIAA0391 - kiaa0391, METTL12 - methyltransferase like 12, FAM173A - family with sequence similarity 173, member a, TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), TET2 - tet methylcytosine dioxygenase 2, BEND3 - ben domain containing 3, TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), LCMT2 - leucine carboxyl methyltransferase 2, PRMT3 - protein arginine methyltransferase 3, FAM173B - family with sequence similarity 173, member b, PWP1 - pwp1 homolog (s. cerevisiae), C6orf211 - chromosome 6 open reading frame 211, CARM1 - coactivator-associated arginine methyltransferase 1, CBLL1 - cbl proto-oncogene-like 1, e3 ubiquitin protein ligase, MGMT - o-6-methylguanine-dna methyltransferase]" GO:0006351 "transcription, DNA-templated" 2.19E-04 6.32E-01 1.98 6191 173 670 37 "[TAF9 - taf9 rna polymerase ii, tata box binding protein (tbp)-associated factor, 32kda, TAF7 - taf7 rna polymerase ii, tata box binding protein (tbp)-associated factor, 55kda, TAF4B - taf4b rna polymerase ii, tata box binding protein (tbp)-associated factor, 105kda, HSF1 - heat shock transcription factor 1, TAF5L - taf5-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, JUN - jun proto-oncogene, TEFM - transcription elongation factor, mitochondrial, NPM3 - nucleophosmin/nucleoplasmin 3, ZBTB1 - zinc finger and btb domain containing 1, EAF1 - ell associated factor 1, TFDP1 - transcription factor dp-1, DRAP1 - dr1-associated protein 1 (negative cofactor 2 alpha), TFB2M - transcription factor b2, mitochondrial, NFIL3 - nuclear factor, interleukin 3 regulated, NABP2 - nucleic acid binding protein 2, C10orf2 - chromosome 10 open reading frame 2, SIRT7 - sirtuin 7, GTF2A2 - general transcription factor iia, 2, 12kda, TAF12 - taf12 rna polymerase ii, tata box binding protein (tbp)-associated factor, 20kda, TAF13 - taf13 rna polymerase ii, tata box binding protein (tbp)-associated factor, 18kda, NELFB - negative elongation factor complex member b, GTF2A1 - general transcription factor iia, 1, 19/37kda, BAZ2A - bromodomain adjacent to zinc finger domain, 2a, PHRF1 - phd and ring finger domains 1, CDK9 - cyclin-dependent kinase 9, POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, CDK7 - cyclin-dependent kinase 7, GTF3A - general transcription factor iiia, MRPL12 - mitochondrial ribosomal protein l12, E2F1 - e2f transcription factor 1, PWP1 - pwp1 homolog (s. cerevisiae), ZC3H8 - zinc finger ccch-type containing 8, GTF3C4 - general transcription factor iiic, polypeptide 4, 90kda, TCEANC2 - transcription elongation factor a (sii) n-terminal and central domain containing 2, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, USPL1 - ubiquitin specific peptidase like 1, POLR3K - polymerase (rna) iii (dna directed) polypeptide k, 12.3 kda]" GO:0097659 nucleic acid-templated transcription 2.43E-04 5.62E-01 1.96 6191 174 670 37 "[TAF9 - taf9 rna polymerase ii, tata box binding protein (tbp)-associated factor, 32kda, TAF7 - taf7 rna polymerase ii, tata box binding protein (tbp)-associated factor, 55kda, TAF4B - taf4b rna polymerase ii, tata box binding protein (tbp)-associated factor, 105kda, HSF1 - heat shock transcription factor 1, TAF5L - taf5-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, NPM3 - nucleophosmin/nucleoplasmin 3, TEFM - transcription elongation factor, mitochondrial, JUN - jun proto-oncogene, ZBTB1 - zinc finger and btb domain containing 1, EAF1 - ell associated factor 1, TFDP1 - transcription factor dp-1, DRAP1 - dr1-associated protein 1 (negative cofactor 2 alpha), TFB2M - transcription factor b2, mitochondrial, NFIL3 - nuclear factor, interleukin 3 regulated, NABP2 - nucleic acid binding protein 2, C10orf2 - chromosome 10 open reading frame 2, SIRT7 - sirtuin 7, GTF2A2 - general transcription factor iia, 2, 12kda, TAF12 - taf12 rna polymerase ii, tata box binding protein (tbp)-associated factor, 20kda, TAF13 - taf13 rna polymerase ii, tata box binding protein (tbp)-associated factor, 18kda, GTF2A1 - general transcription factor iia, 1, 19/37kda, NELFB - negative elongation factor complex member b, BAZ2A - bromodomain adjacent to zinc finger domain, 2a, PHRF1 - phd and ring finger domains 1, CDK9 - cyclin-dependent kinase 9, POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, CDK7 - cyclin-dependent kinase 7, GTF3A - general transcription factor iiia, MRPL12 - mitochondrial ribosomal protein l12, E2F1 - e2f transcription factor 1, PWP1 - pwp1 homolog (s. cerevisiae), ZC3H8 - zinc finger ccch-type containing 8, GTF3C4 - general transcription factor iiic, polypeptide 4, 90kda, TCEANC2 - transcription elongation factor a (sii) n-terminal and central domain containing 2, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, USPL1 - ubiquitin specific peptidase like 1, POLR3K - polymerase (rna) iii (dna directed) polypeptide k, 12.3 kda]" GO:0006390 mitochondrial transcription 2.70E-04 5.20E-01 5.84 6191 7 908 6 "[TFB2M - transcription factor b2, mitochondrial, POLRMT - polymerase (rna) mitochondrial (dna directed), C10orf2 - chromosome 10 open reading frame 2, TEFM - transcription elongation factor, mitochondrial, SLC25A33 - solute carrier family 25 (pyrimidine nucleotide carrier), member 33, MRPL12 - mitochondrial ribosomal protein l12]" GO:0034660 ncRNA metabolic process 2.80E-04 4.62E-01 1.72 6191 309 641 55 "[WDR4 - wd repeat domain 4, EXOSC5 - exosome component 5, C9orf156 - chromosome 9 open reading frame 156, PLD6 - phospholipase d family, member 6, RPF2 - ribosome production factor 2 homolog (s. cerevisiae), FAM207A - family with sequence similarity 207, member a, TFB2M - transcription factor b2, mitochondrial, BOP1 - block of proliferation 1, SIRT7 - sirtuin 7, GTF2A2 - general transcription factor iia, 2, 12kda, UTP20 - utp20, small subunit (ssu) processome component, homolog (yeast), GTF2A1 - general transcription factor iia, 1, 19/37kda, UTP3 - utp3, small subunit (ssu) processome component, homolog (s. cerevisiae), TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), GTF3A - general transcription factor iiia, TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), RPUSD1 - rna pseudouridylate synthase domain containing 1, KTI12 - kti12 homolog, chromatin associated (s. cerevisiae), DDX51 - dead (asp-glu-ala-asp) box polypeptide 51, TP53RK - tp53 regulating kinase, ZC3H8 - zinc finger ccch-type containing 8, DCAF13 - ddb1 and cul4 associated factor 13, EXOSC6 - exosome component 6, USPL1 - ubiquitin specific peptidase like 1, WDR18 - wd repeat domain 18, TAF9 - taf9 rna polymerase ii, tata box binding protein (tbp)-associated factor, 32kda, BMS1 - bms1 ribosome biogenesis factor, RPP21 - ribonuclease p/mrp 21kda subunit, NPM3 - nucleophosmin/nucleoplasmin 3, RPS16 - ribosomal protein s16, QTRT1 - queuine trna-ribosyltransferase 1, EIF4A3 - eukaryotic translation initiation factor 4a3, NABP2 - nucleic acid binding protein 2, XRN2 - 5'-3' exoribonuclease 2, TRPT1 - trna phosphotransferase 1, HARS - histidyl-trna synthetase, BCDIN3D - bcdin3 domain containing, CTU1 - cytosolic thiouridylase subunit 1, TAF13 - taf13 rna polymerase ii, tata box binding protein (tbp)-associated factor, 18kda, IMP4 - imp4, u3 small nucleolar ribonucleoprotein, homolog (yeast), KIAA0391 - kiaa0391, CDK9 - cyclin-dependent kinase 9, POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, CDK7 - cyclin-dependent kinase 7, TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), LCMT2 - leucine carboxyl methyltransferase 2, TSEN54 - tsen54 trna splicing endonuclease subunit, EXOSC4 - exosome component 4, NOP10 - nop10 ribonucleoprotein, MOCS3 - molybdenum cofactor synthesis 3, RPS28 - ribosomal protein s28, GTF3C4 - general transcription factor iiic, polypeptide 4, 90kda, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, YBEY - ybey metallopeptidase (putative), PARS2 - prolyl-trna synthetase 2, mitochondrial (putative)]" GO:0001738 morphogenesis of a polarized epithelium 2.88E-04 4.16E-01 93.8 6191 3 44 2 "[ACTG1 - actin, gamma 1, LAMA5 - laminin, alpha 5]" GO:0090304 nucleic acid metabolic process 2.93E-04 3.77E-01 1.35 6191 1087 652 154 "[EXOSC5 - exosome component 5, RTEL1 - regulator of telomere elongation helicase 1, HSF1 - heat shock transcription factor 1, SYF2 - syf2 pre-mrna-splicing factor, ORC1 - origin recognition complex, subunit 1, HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PLD6 - phospholipase d family, member 6, DRAP1 - dr1-associated protein 1 (negative cofactor 2 alpha), BOP1 - block of proliferation 1, PCBP1 - poly(rc) binding protein 1, ZFP36L2 - zfp36 ring finger protein-like 2, GTF2A2 - general transcription factor iia, 2, 12kda, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), UTP20 - utp20, small subunit (ssu) processome component, homolog (yeast), GTF2A1 - general transcription factor iia, 1, 19/37kda, NELFB - negative elongation factor complex member b, KRBA2 - krab-a domain containing 2, GTF3A - general transcription factor iiia, RPUSD1 - rna pseudouridylate synthase domain containing 1, KTI12 - kti12 homolog, chromatin associated (s. cerevisiae), RCHY1 - ring finger and chy zinc finger domain containing 1, e3 ubiquitin protein ligase, TAF6L - taf6-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, OTUB1 - otu domain, ubiquitin aldehyde binding 1, TP53RK - tp53 regulating kinase, ZC3H8 - zinc finger ccch-type containing 8, DCAF13 - ddb1 and cul4 associated factor 13, EXOSC6 - exosome component 6, USPL1 - ubiquitin specific peptidase like 1, CSTF2T - cleavage stimulation factor, 3' pre-rna, subunit 2, 64kda, tau variant, POLR3K - polymerase (rna) iii (dna directed) polypeptide k, 12.3 kda, WDR18 - wd repeat domain 18, NR1D1 - nuclear receptor subfamily 1, group d, member 1, TAF9 - taf9 rna polymerase ii, tata box binding protein (tbp)-associated factor, 32kda, SNRPB2 - small nuclear ribonucleoprotein polypeptide b, BMS1 - bms1 ribosome biogenesis factor, TAF7 - taf7 rna polymerase ii, tata box binding protein (tbp)-associated factor, 55kda, RPP21 - ribonuclease p/mrp 21kda subunit, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, TAF4B - taf4b rna polymerase ii, tata box binding protein (tbp)-associated factor, 105kda, SNRPE - small nuclear ribonucleoprotein polypeptide e, MCMBP - minichromosome maintenance complex binding protein, SNORA43 - small nucleolar rna, h/aca box 43, JMY - junction mediating and regulatory protein, p53 cofactor, NTHL1 - nth endonuclease iii-like 1 (e. coli), QTRT1 - queuine trna-ribosyltransferase 1, EIF4A3 - eukaryotic translation initiation factor 4a3, NABP2 - nucleic acid binding protein 2, HUS1 - hus1 checkpoint homolog (s. pombe), HARS - histidyl-trna synthetase, BCDIN3D - bcdin3 domain containing, CTU1 - cytosolic thiouridylase subunit 1, TAF12 - taf12 rna polymerase ii, tata box binding protein (tbp)-associated factor, 20kda, TAF13 - taf13 rna polymerase ii, tata box binding protein (tbp)-associated factor, 18kda, RBM15B - rna binding motif protein 15b, BAZ2A - bromodomain adjacent to zinc finger domain, 2a, IMP4 - imp4, u3 small nucleolar ribonucleoprotein, homolog (yeast), SNORA9 - small nucleolar rna, h/aca box 9, CDK9 - cyclin-dependent kinase 9, LSM5 - lsm5 homolog, u6 small nuclear rna associated (s. cerevisiae), POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, CDK7 - cyclin-dependent kinase 7, TET2 - tet methylcytosine dioxygenase 2, EME2 - essential meiotic structure-specific endonuclease subunit 2, LCMT2 - leucine carboxyl methyltransferase 2, LSM1 - lsm1 homolog, u6 small nuclear rna associated (s. cerevisiae), E2F1 - e2f transcription factor 1, SNORD60 - small nucleolar rna, c/d box 60, TSEN54 - tsen54 trna splicing endonuclease subunit, PWP1 - pwp1 homolog (s. cerevisiae), CTIF - cbp80/20-dependent translation initiation factor, NOP10 - nop10 ribonucleoprotein, SNRNP25 - small nuclear ribonucleoprotein 25kda (u11/u12), MOCS3 - molybdenum cofactor synthesis 3, ELAC1 - elac ribonuclease z 1, TCEANC2 - transcription elongation factor a (sii) n-terminal and central domain containing 2, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, MGMT - o-6-methylguanine-dna methyltransferase, YBEY - ybey metallopeptidase (putative), PARS2 - prolyl-trna synthetase 2, mitochondrial (putative), SNORD4A - small nucleolar rna, c/d box 4a, SNORD68 - small nucleolar rna, c/d box 68, WDR4 - wd repeat domain 4, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, C9orf156 - chromosome 9 open reading frame 156, MAGOH - mago-nashi homolog, proliferation-associated (drosophila), TAF5L - taf5-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, RPL19 - ribosomal protein l19, ZBTB1 - zinc finger and btb domain containing 1, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), EAF1 - ell associated factor 1, SMC3 - structural maintenance of chromosomes 3, RPF2 - ribosome production factor 2 homolog (s. cerevisiae), FAM207A - family with sequence similarity 207, member a, TFB2M - transcription factor b2, mitochondrial, SUPV3L1 - suppressor of var1, 3-like 1 (s. cerevisiae), FANCF - fanconi anemia, complementation group f, SIRT7 - sirtuin 7, SIRT1 - sirtuin 1, UBL5 - ubiquitin-like 5, C19orf40 - chromosome 19 open reading frame 40, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ZBTB48 - zinc finger and btb domain containing 48, MAZ - myc-associated zinc finger protein (purine-binding transcription factor), UTP3 - utp3, small subunit (ssu) processome component, homolog (s. cerevisiae), TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), MRPL12 - mitochondrial ribosomal protein l12, TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), FASTKD5 - fast kinase domains 5, ZCRB1 - zinc finger cchc-type and rna binding motif 1, DDX51 - dead (asp-glu-ala-asp) box polypeptide 51, RPL38 - ribosomal protein l38, RTFDC1 - replication termination factor 2 domain containing 1, RAD9A - rad9 homolog a (s. pombe), AURKAIP1 - aurora kinase a interacting protein 1, RPL28 - ribosomal protein l28, LONP1 - lon peptidase 1, mitochondrial, SF3B14 - splicing factor 3b, 14 kda subunit, GRWD1 - glutamate-rich wd repeat containing 1, NPM3 - nucleophosmin/nucleoplasmin 3, JUN - jun proto-oncogene, UBE2B - ubiquitin-conjugating enzyme e2b, RPS16 - ribosomal protein s16, RNASEK - ribonuclease, rnase k, RPS18 - ribosomal protein s18, TFDP1 - transcription factor dp-1, NFIL3 - nuclear factor, interleukin 3 regulated, C10orf2 - chromosome 10 open reading frame 2, RHNO1 - rad9-hus1-rad1 interacting nuclear orphan 1, TRPT1 - trna phosphotransferase 1, XRN2 - 5'-3' exoribonuclease 2, SESN2 - sestrin 2, TGS1 - trimethylguanosine synthase 1, CDK2AP1 - cyclin-dependent kinase 2 associated protein 1, POLE4 - polymerase (dna-directed), epsilon 4, accessory subunit, PHRF1 - phd and ring finger domains 1, KIAA0391 - kiaa0391, U2AF2 - u2 small nuclear rna auxiliary factor 2, MTERF - mitochondrial transcription termination factor, ZNF830 - zinc finger protein 830, TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), BEND3 - ben domain containing 3, SFSWAP - splicing factor, suppressor of white-apricot homolog (drosophila), BRF2 - brf2, rna polymerase iii transcription initiation factor 50 kda subunit, EXOSC4 - exosome component 4, XRCC3 - x-ray repair complementing defective repair in chinese hamster cells 3, RBX1 - ring-box 1, e3 ubiquitin protein ligase, COPS7A - cop9 signalosome subunit 7a, SNORD3A - small nucleolar rna, c/d box 3a, UBE2V2 - ubiquitin-conjugating enzyme e2 variant 2, RPS28 - ribosomal protein s28, GTF3C4 - general transcription factor iiic, polypeptide 4, 90kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2, PNKP - polynucleotide kinase 3'-phosphatase, UBE2N - ubiquitin-conjugating enzyme e2n]" GO:0005981 regulation of glycogen catabolic process 3.27E-04 3.78E-01 87.82 6191 3 47 2 "[PPP1R3D - protein phosphatase 1, regulatory subunit 3d, PPP1R3B - protein phosphatase 1, regulatory subunit 3b]" GO:0022613 ribonucleoprotein complex biogenesis 3.34E-04 3.51E-01 3.33 6191 45 579 14 "[LTV1 - ltv1 homolog (s. cerevisiae), RPS16 - ribosomal protein s16, ZNF622 - zinc finger protein 622, GTF3A - general transcription factor iiia, CEBPZ - ccaat/enhancer binding protein (c/ebp), zeta, RPF2 - ribosome production factor 2 homolog (s. cerevisiae), PWP1 - pwp1 homolog (s. cerevisiae), BOP1 - block of proliferation 1, NIP7 - nip7, nucleolar pre-rrna processing protein, PAK1IP1 - pak1 interacting protein 1, RPS28 - ribosomal protein s28, TGS1 - trimethylguanosine synthase 1, URB2 - urb2 ribosome biogenesis 2 homolog (s. cerevisiae), SURF6 - surfeit 6]" GO:0046483 heterocycle metabolic process 5.08E-04 4.89E-01 1.27 6191 1361 734 205 "[POP1 - processing of precursor 1, ribonuclease p/mrp subunit (s. cerevisiae), EXOSC5 - exosome component 5, HSF1 - heat shock transcription factor 1, SCD5 - stearoyl-coa desaturase 5, THEM4 - thioesterase superfamily member 4, HNRNPA0 - heterogeneous nuclear ribonucleoprotein a0, PLD6 - phospholipase d family, member 6, COX10 - cytochrome c oxidase assembly homolog 10 (yeast), ZFP36L2 - zfp36 ring finger protein-like 2, PMM2 - phosphomannomutase 2, DDX12P - dead/h (asp-glu-ala-asp/his) box polypeptide 12, pseudogene, PMM1 - phosphomannomutase 1, CWC22 - cwc22 spliceosome-associated protein homolog (s. cerevisiae), ENO1 - enolase 1, (alpha), RLF - rearranged l-myc fusion, ALYREF - aly/ref export factor, OTUB1 - otu domain, ubiquitin aldehyde binding 1, BLVRA - biliverdin reductase a, ZC3H8 - zinc finger ccch-type containing 8, EXOSC6 - exosome component 6, USPL1 - ubiquitin specific peptidase like 1, NR1D1 - nuclear receptor subfamily 1, group d, member 1, SNRPB2 - small nuclear ribonucleoprotein polypeptide b, RPP21 - ribonuclease p/mrp 21kda subunit, SNRPD2 - small nuclear ribonucleoprotein d2 polypeptide 16.5kda, SNRPE - small nuclear ribonucleoprotein polypeptide e, MCMBP - minichromosome maintenance complex binding protein, QTRT1 - queuine trna-ribosyltransferase 1, NABP2 - nucleic acid binding protein 2, HUS1 - hus1 checkpoint homolog (s. pombe), RBM15B - rna binding motif protein 15b, IMP4 - imp4, u3 small nucleolar ribonucleoprotein, homolog (yeast), LSM5 - lsm5 homolog, u6 small nuclear rna associated (s. cerevisiae), POLR2L - polymerase (rna) ii (dna directed) polypeptide l, 7.6kda, C1QBP - complement component 1, q subcomponent binding protein, TET2 - tet methylcytosine dioxygenase 2, ADK - adenosine kinase, MUT - methylmalonyl coa mutase, EME2 - essential meiotic structure-specific endonuclease subunit 2, MVD - mevalonate (diphospho) decarboxylase, SNORD60 - small nucleolar rna, c/d box 60, GNAI3 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 3, E2F1 - e2f transcription factor 1, NOP10 - nop10 ribonucleoprotein, FZR1 - fizzy/cell division cycle 20 related 1 (drosophila), ELAC1 - elac ribonuclease z 1, TCEANC2 - transcription elongation factor a (sii) n-terminal and central domain containing 2, POLR2E - polymerase (rna) ii (dna directed) polypeptide e, 25kda, SNORD4A - small nucleolar rna, c/d box 4a, SNORD68 - small nucleolar rna, c/d box 68, TYMP - thymidine phosphorylase, CSTF1 - cleavage stimulation factor, 3' pre-rna, subunit 1, 50kda, RPL19 - ribosomal protein l19, RPF2 - ribosome production factor 2 homolog (s. cerevisiae), SUPV3L1 - suppressor of var1, 3-like 1 (s. cerevisiae), FANCF - fanconi anemia, complementation group f, UBL5 - ubiquitin-like 5, C19orf40 - chromosome 19 open reading frame 40, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ZBTB48 - zinc finger and btb domain containing 48, HK2 - hexokinase 2, TSR3 - tsr3, 20s rrna accumulation, homolog (s. cerevisiae), UTP3 - utp3, small subunit (ssu) processome component, homolog (s. cerevisiae), MRPL12 - mitochondrial ribosomal protein l12, TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), FASTKD5 - fast kinase domains 5, DDX51 - dead (asp-glu-ala-asp) box polypeptide 51, EXTL2 - exostosin-like glycosyltransferase 2, RPL38 - ribosomal protein l38, ABCB6 - atp-binding cassette, sub-family b (mdr/tap), member 6, AURKAIP1 - aurora kinase a interacting protein 1, CBLL1 - cbl proto-oncogene-like 1, e3 ubiquitin protein ligase, RPL28 - ribosomal protein l28, LONP1 - lon peptidase 1, mitochondrial, ALOX5 - arachidonate 5-lipoxygenase, NPM3 - nucleophosmin/nucleoplasmin 3, TEFM - transcription elongation factor, mitochondrial, LIAS - lipoic acid synthetase, JUN - jun proto-oncogene, MACROD1 - macro domain containing 1, UBE2B - ubiquitin-conjugating enzyme e2b, RPS16 - ribosomal protein s16, BUD13 - bud13 homolog (s. cerevisiae), ERH - enhancer of rudimentary homolog (drosophila), RPS18 - ribosomal protein s18, UCKL1 - uridine-cytidine kinase 1-like 1, CDK2AP1 - cyclin-dependent kinase 2 associated protein 1, SNIP1 - smad nuclear interacting protein 1, MTERF - mitochondrial transcription termination factor, ZNF830 - zinc finger protein 830, RBX1 - ring-box 1, e3 ubiquitin protein ligase, SRD5A1 - steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1), RPS28 - ribosomal protein s28, UBE2V2 - ubiquitin-conjugating enzyme e2 variant 2, GTF3C4 - general transcription factor iiic, polypeptide 4, 90kda, CD2BP2 - cd2 (cytoplasmic tail) binding protein 2, UBE2N - ubiquitin-conjugating enzyme e2n, PAICS - phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, RTEL1 - regulator of telomere elongation helicase 1, SYF2 - syf2 pre-mrna-splicing factor, ORC1 - origin recognition complex, subunit 1, PNPO - pyridoxamine 5'-phosphate oxidase, DRAP1 - dr1-associated protein 1 (negative cofactor 2 alpha), DNPH1 - 2'-deoxynucleoside 5'-phosphate n-hydrolase 1, BOP1 - block of proliferation 1, PCBP1 - poly(rc) binding protein 1, PCCB - propionyl coa carboxylase, beta polypeptide, GTF2A2 - general transcription factor iia, 2, 12kda, UTP20 - utp20, small subunit (ssu) processome component, homolog (yeast), GTF2A1 - general transcription factor iia, 1, 19/37kda, NELFB - negative elongation factor complex member b, KRBA2 - krab-a domain containing 2, GTF3A - general transcription factor iiia, RPUSD1 - rna pseudouridylate synthase domain containing 1, RCHY1 - ring finger and chy zinc finger domain containing 1, e3 ubiquitin protein ligase, KTI12 - kti12 homolog, chromatin associated (s. cerevisiae), TAF6L - taf6-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, SMG6 - smg6 nonsense mediated mrna decay factor, RAB23 - rab23, member ras oncogene family, TP53RK - tp53 regulating kinase, DCAF13 - ddb1 and cul4 associated factor 13, POLR3K - polymerase (rna) iii (dna directed) polypeptide k, 12.3 kda, CSTF2T - cleavage stimulation factor, 3' pre-rna, subunit 2, 64kda, tau variant, WDR18 - wd repeat domain 18, TAF9 - taf9 rna polymerase ii, tata box binding protein (tbp)-associated factor, 32kda, BMS1 - bms1 ribosome biogenesis factor, TAF7 - taf7 rna polymerase ii, tata box binding protein (tbp)-associated factor, 55kda, SCD - stearoyl-coa desaturase (delta-9-desaturase), TAF4B - taf4b rna polymerase ii, tata box binding protein (tbp)-associated factor, 105kda, SNORA43 - small nucleolar rna, h/aca box 43, PDHB - pyruvate dehydrogenase (lipoamide) beta, CTU2 - cytosolic thiouridylase subunit 2 homolog (s. pombe), JMY - junction mediating and regulatory protein, p53 cofactor, NTHL1 - nth endonuclease iii-like 1 (e. coli), EIF4A3 - eukaryotic translation initiation factor 4a3, RHOA - ras homolog family member a, HARS - histidyl-trna synthetase, BCDIN3D - bcdin3 domain containing, CTU1 - cytosolic thiouridylase subunit 1, TAF12 - taf12 rna polymerase ii, tata box binding protein (tbp)-associated factor, 20kda, TAF13 - taf13 rna polymerase ii, tata box binding protein (tbp)-associated factor, 18kda, BAZ2A - bromodomain adjacent to zinc finger domain, 2a, SNORA9 - small nucleolar rna, h/aca box 9, CDK9 - cyclin-dependent kinase 9, CDK7 - cyclin-dependent kinase 7, LCMT2 - leucine carboxyl methyltransferase 2, LSM1 - lsm1 homolog, u6 small nuclear rna associated (s. cerevisiae), TSEN54 - tsen54 trna splicing endonuclease subunit, PWP1 - pwp1 homolog (s. cerevisiae), CTIF - cbp80/20-dependent translation initiation factor, MOCS3 - molybdenum cofactor synthesis 3, SNRNP25 - small nuclear ribonucleoprotein 25kda (u11/u12), MGMT - o-6-methylguanine-dna methyltransferase, YBEY - ybey metallopeptidase (putative), PARS2 - prolyl-trna synthetase 2, mitochondrial (putative), WDR4 - wd repeat domain 4, UCK1 - uridine-cytidine kinase 1, C9orf156 - chromosome 9 open reading frame 156, RRP9 - ribosomal rna processing 9, small subunit (ssu) processome component, homolog (yeast), MAGOH - mago-nashi homolog, proliferation-associated (drosophila), TAF5L - taf5-like rna polymerase ii, p300/cbp-associated factor (pcaf)-associated factor, 65kda, ZBTB1 - zinc finger and btb domain containing 1, PRPF4 - prp4 pre-mrna processing factor 4 homolog (yeast), EAF1 - ell associated factor 1, SMC3 - structural maintenance of chromosomes 3, NME3 - nme/nm23 nucleoside diphosphate kinase 3, FAM207A - family with sequence similarity 207, member a, TFB2M - transcription factor b2, mitochondrial, SIRT7 - sirtuin 7, SIRT1 - sirtuin 1, ENPP4 - ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative), MAZ - myc-associated zinc finger protein (purine-binding transcription factor), ATP5J - atp synthase, h+ transporting, mitochondrial fo complex, subunit f6, ZCRB1 - zinc finger cchc-type and rna binding motif 1, ATP5E - atp synthase, h+ transporting, mitochondrial f1 complex, epsilon subunit, RTFDC1 - replication termination factor 2 domain containing 1, SLC26A2 - solute carrier family 26 (anion exchanger), member 2, RAD9A - rad9 homolog a (s. pombe), NT5C - 5', 3'-nucleotidase, cytosolic, SF3B14 - splicing factor 3b, 14 kda subunit, GRWD1 - glutamate-rich wd repeat containing 1, GPX1 - glutathione peroxidase 1, RNASEK - ribonuclease, rnase k, TFDP1 - transcription factor dp-1, NFIL3 - nuclear factor, interleukin 3 regulated, C10orf2 - chromosome 10 open reading frame 2, RHNO1 - rad9-hus1-rad1 interacting nuclear orphan 1, XRN2 - 5'-3' exoribonuclease 2, TRPT1 - trna phosphotransferase 1, DHFR - dihydrofolate reductase, SESN2 - sestrin 2, TGS1 - trimethylguanosine synthase 1, POLE4 - polymerase (dna-directed), epsilon 4, accessory subunit, PHRF1 - phd and ring finger domains 1, KIAA0391 - kiaa0391, U2AF2 - u2 small nuclear rna auxiliary factor 2, TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), BEND3 - ben domain containing 3, SFSWAP - splicing factor, suppressor of white-apricot homolog (drosophila), EXOSC4 - exosome component 4, BRF2 - brf2, rna polymerase iii transcription initiation factor 50 kda subunit, XRCC3 - x-ray repair complementing defective repair in chinese hamster cells 3, COPS7A - cop9 signalosome subunit 7a, SNORD3A - small nucleolar rna, c/d box 3a, PNKP - polynucleotide kinase 3'-phosphatase]" GO:0032259 methylation 5.25E-04 4.67E-01 2.13 6191 127 687 30 "[WDR4 - wd repeat domain 4, WDR82 - wd repeat domain 82, C9orf156 - chromosome 9 open reading frame 156, PLD6 - phospholipase d family, member 6, TFB2M - transcription factor b2, mitochondrial, BCDIN3D - bcdin3 domain containing, COMTD1 - catechol-o-methyltransferase domain containing 1, TGS1 - trimethylguanosine synthase 1, SIRT7 - sirtuin 7, WDR5B - wd repeat domain 5b, RBM15B - rna binding motif protein 15b, BAZ2A - bromodomain adjacent to zinc finger domain, 2a, SETD8 - set domain containing (lysine methyltransferase) 8, RLF - rearranged l-myc fusion, KIAA0391 - kiaa0391, METTL12 - methyltransferase like 12, FAM173A - family with sequence similarity 173, member a, TRMT13 - trna methyltransferase 13 homolog (s. cerevisiae), TET2 - tet methylcytosine dioxygenase 2, BEND3 - ben domain containing 3, TRMT61A - trna methyltransferase 61 homolog a (s. cerevisiae), LCMT2 - leucine carboxyl methyltransferase 2, PRMT3 - protein arginine methyltransferase 3, FAM173B - family with sequence similarity 173, member b, C6orf211 - chromosome 6 open reading frame 211, PWP1 - pwp1 homolog (s. cerevisiae), CARM1 - coactivator-associated arginine methyltransferase 1, METTL23 - methyltransferase like 23, CBLL1 - cbl proto-oncogene-like 1, e3 ubiquitin protein ligase, MGMT - o-6-methylguanine-dna methyltransferase]" GO:0044262 cellular carbohydrate metabolic process 6.18E-04 5.11E-01 11.55 6191 57 47 5 "[PPP1R3D - protein phosphatase 1, regulatory subunit 3d, GNPTG - n-acetylglucosamine-1-phosphate transferase, gamma subunit, B3GNT9 - udp-glcnac:betagal beta-1,3-n-acetylglucosaminyltransferase 9, HK2 - hexokinase 2, PPP1R3B - protein phosphatase 1, regulatory subunit 3b]" GO:0018023 peptidyl-lysine trimethylation 7.39E-04 5.70E-01 5.63 6191 18 428 7 "[FAM173B - family with sequence similarity 173, member b, PWP1 - pwp1 homolog (s. cerevisiae), WDR82 - wd repeat domain 82, METTL12 - methyltransferase like 12, FAM173A - family with sequence similarity 173, member a, TET2 - tet methylcytosine dioxygenase 2, BEND3 - ben domain containing 3]"