Supplemental Table S11: Functional enrichments for sex-specific eQTL genes that match murine fold
change gene orthologs.
Term: Functional annotation.
P.value: The nominal p-value
Adjusted.P.value: the FDR
Odds.Ratio: The odds ratio
Genes: The genes associated with the functional annotation
source: The source of the functional annotation
nge: The number of genes associated with the functional annotation

Term	P.value	Adjusted.P.value	Odds.Ratio	Genes	source	nge
Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor Homo sapiens R-HSA-156988	9.85663123962352e-05	0.01675627310736	15.4858691444057	JAG2;NOTCH3;ADAM10;UBA52	Reactome_2016	4
CD40 receptor complex (GO:0035631)	0.000920697445580595	0.0410631060728945	14.7819660014782	CD40;CHUK;BIRC2	GO_Cellular_Component_2018	3
integral component of mitochondrial outer membrane (GO:0031307)	0.000532093570642798	0.0395522887511147	10.3239127629372	PINK1;MFN1;MUL1;SLC25A44	GO_Cellular_Component_2018	4
Pink/Parkin Mediated Mitophagy Homo sapiens R-HSA-5205685	0.000640936291312615	0.049031626285415	9.85464400098546	PINK1;MFN1;UBA52;ATG12	Reactome_2016	4
Mitophagy Homo sapiens R-HSA-5205647	0.000640936291312615	0.0466967869384905	9.85464400098546	PINK1;MFN1;UBA52;ATG12	Reactome_2016	4
intrinsic component of mitochondrial outer membrane (GO:0031306)	0.000640936291312615	0.0357321982406783	9.85464400098546	PINK1;MFN1;MUL1;SLC25A44	GO_Cellular_Component_2018	4
Gap-filling DNA repair synthesis and ligation in GG-NER Homo sapiens R-HSA-5696397	0.000764662284385022	0.0487472206295452	9.42618121833392	PCNA;POLE2;POLK;UBA52	Reactome_2016	4
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade Homo sapiens P00032	0.000171567789985297	0.00960779623917664	9.34492103541725	RPS6KA4;IGF2;MAPK1;FOS;SOS2	Panther_2016	5
Canonical  and Non-canonical Notch signaling WP3845	0.0014299466327709	0.0482096293334188	8.0297099267289	JAG2;NOTCH3;CHUK;ADAM10	WikiPathways_2019_Human	4
Thyroid cancer	0.000558051151974579	0.0132215196006285	7.32439756830001	RET;CCDC6;MAPK1;KRAS;POLK	KEGG_2019_Human	5
beta-Alanine metabolism	0.00241933362240447	0.0372577377850289	6.99361832328001	CARNS1;ABAT;MLYCD;ALDH9A1	KEGG_2019_Human	4
Dual Incision in GG-NER Homo sapiens R-HSA-5696400	0.00071521266252136	0.0497397897117128	6.94878743659231	PCNA;PARP1;POLE2;POLK;UBA52	Reactome_2016	5
Propanoate metabolism	0.00272523596843002	0.036494464272889	6.77506775067751	SUCLA2;PCCA;ABAT;MLYCD	KEGG_2019_Human	4
B cell activation Homo sapiens P00010	8.22093665510686e-05	0.00920744905371968	6.65620691294632	VAV3;CHUK;PLCG2;MAPK1;PTPN6;FOS;SOS2	Panther_2016	7
Complex I biogenesis Homo sapiens R-HSA-6799198	0.000271104221094446	0.0276526305516335	6.63680106188817	NDUFB8;NDUFA11;NDUFA3;NDUFA10;NDUFAB1;NDUFC1	Reactome_2016	6
Base excision repair	0.00305661344786128	0.0362091131515875	6.56976266732364	PCNA;PARP1;POLE2;MUTYH	KEGG_2019_Human	4
TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway WP2036	0.00101003671687514	0.0476737330365065	6.45244547683572	CASP7;CHUK;CCL2;MAPK1;BIRC2	WikiPathways_2019_Human	5
mitochondrial ATP synthesis coupled electron transport (GO:0042775)	3.70483619704078e-06	0.00945288955674954	6.37653435357883	NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;COX6B1	GO_Biological_Process_2018	10
mitochondrial respiratory chain complex I (GO:0005747)	0.0003385113267408	0.0377440129315992	6.37653435357883	NDUFB8;NDUFA11;NDUFA3;NDUFA10;NDUFAB1;NDUFC1	GO_Cellular_Component_2018	6
respiratory electron transport chain (GO:0022904)	1.27677274116775e-06	0.00651537129817902	6.34261661765554	NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;PPARGC1A;COX6B1	GO_Biological_Process_2018	11
mitochondrial large ribosomal subunit (GO:0005762)	0.000376793239040173	0.0336099569223834	6.25390869293308	MRPL51;MRPL19;MRPL39;MRPL45;MRPL44;MRPL55	GO_Cellular_Component_2018	6
Respiratory electron transport Homo sapiens R-HSA-611105	5.08862428577826e-06	0.00259519838574691	6.15915250061591	NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;COX6B1	Reactome_2016	10
B cell receptor signaling pathway	4.80759746671889e-05	0.0024679000329157	6.10710332455437	VAV3;CHUK;PLCG2;MAPK1;PTPN6;KRAS;FOS;SOS2	KEGG_2019_Human	8
T cell receptor signaling pathway	1.7521737234727e-05	0.00134917376707398	5.36639029756634	VAV3;TEC;CHUK;LCK;MAPK1;PTPN6;KRAS;FOS;CD247;SOS2	KEGG_2019_Human	10
Th1 and Th2 cell differentiation	5.0720011211627e-05	0.00223168049331159	5.30222693531283	JAG2;NOTCH3;CHUK;LCK;IFNGR2;MAPK1;STAT6;FOS;CD247	KEGG_2019_Human	9
T cell activation Homo sapiens P00053	0.000393765894401964	0.0147005933910066	5.19731224709507	VAV3;CHUK;LCK;MAPK1;FOS;CD247;SOS2	Panther_2016	7
cellular response to oxidative stress (GO:0034599)	9.3201666974001e-06	0.0158536035522776	5.18439967008366	RAD52;PINK1;CHUK;PARP1;TXNRD2;MAPK1;ATP13A2;FOS;MAPT;PPARGC1A;SIRT2	GO_Biological_Process_2018	11
Mitochondrial translation initiation Homo sapiens R-HSA-5368286	0.000160049011328994	0.022261362484851	5.16195638146858	MRPL1;MRPL51;MRPL19;MRPL39;MRPL45;MRPS18C;MRPL44;MRPL55	Reactome_2016	8
Mitochondrial translation termination Homo sapiens R-HSA-5419276	0.000160049011328994	0.0204062489444467	5.16195638146858	MRPL1;MRPL51;MRPL19;MRPL39;MRPL45;MRPS18C;MRPL44;MRPL55	Reactome_2016	8
Mitochondrial translation elongation Homo sapiens R-HSA-5389840	0.000160049011328994	0.0188365374871816	5.16195638146858	MRPL1;MRPL51;MRPL19;MRPL39;MRPL45;MRPS18C;MRPL44;MRPL55	Reactome_2016	8
Endometrial cancer WP4155	0.00106120425580008	0.0455353098852399	5.16195638146858	MAPK1;KRAS;POLK;FOS;SOS2;FGFR2	WikiPathways_2019_Human	6
mitochondrial translation (GO:0032543)	2.90613460662941e-05	0.0370750122440748	5.06547121545982	MRPL1;MRPL51;MRPL19;MRPL39;IARS2;MRPL45;EARS2;MRPS18C;MRPL44;MRPL55	GO_Biological_Process_2018	10
Central carbon metabolism in cancer	0.00125094888356625	0.0226642503610826	5.00312695434647	RET;SLC7A5;FLT3;MAPK1;KRAS;FGFR2	KEGG_2019_Human	6
Oncostatin M Signaling Pathway WP2374	0.00125094888356625	0.0492039894202724	5.00312695434647	CASP7;CCL2;MAPK1;KRAS;FOS;LDLR	WikiPathways_2019_Human	6
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Homo sapiens R-HSA-163200	3.41321417694683e-05	0.00870369615121443	4.97252678948808	NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;COX6B1	Reactome_2016	10
Non-small cell lung cancer	0.00135503176217211	0.0231860990416117	4.92732200049273	PLCG2;MAPK1;KRAS;POLK;STK4;SOS2	KEGG_2019_Human	6
Non-small cell lung cancer WP4255	0.00135503176217211	0.0491980762880952	4.92732200049273	PLCG2;MAPK1;KRAS;POLK;STK4;SOS2	WikiPathways_2019_Human	6
nuclear periphery (GO:0034399)	0.000590242798907048	0.0376068983303634	4.86415120561462	NCOR2;AHCTF1;CENPF;DNMT3A;MAPT;PHB2;IPO5	GO_Cellular_Component_2018	7
Cell surface interactions at the vascular wall Homo sapiens R-HSA-202733	0.000105440814808145	0.0161324446656462	4.82975126780971	SLC7A5;CXADR;SLC16A1;ITGA3;LCK;SIRPA;SLC3A2;PTPN6;KRAS	Reactome_2016	9
Mitochondrial translation Homo sapiens R-HSA-5368287	0.000258613964695062	0.0282628118559604	4.81782595603734	MRPL1;MRPL51;MRPL19;MRPL39;MRPL45;MRPS18C;MRPL44;MRPL55	Reactome_2016	8
Electron Transport Chain (OXPHOS system in mitochondria) WP111	0.000122696653743255	0.014478205141704	4.73596968979399	NDUFB8;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;COX6B1	WikiPathways_2019_Human	9
Adipogenesis WP236	2.97705417250712e-05	0.0140516956942336	4.58619970815093	NCOR2;FOXC2;EGR2;PTGIS;LMNA;CISD1;STAT6;NR3C1;PCK1;PPARGC1A;AGT	WikiPathways_2019_Human	11
Parkinson disease	1.31758157945681e-05	0.00135271708824232	4.58032749341578	NDUFB8;PINK1;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;PPIF;UQCRFS1;NDUFC1;SDHD;COX6B1	KEGG_2019_Human	12
SUMO E3 ligases SUMOylate target proteins Homo sapiens R-HSA-3108232	0.000402079878191946	0.0361871890372752	4.516711833785	TOP2A;RAD52;PCNA;PARP1;NUP50;NSMCE1;NUP35;AAAS	Reactome_2016	8
Oxidative phosphorylation	3.67979371397914e-05	0.00226675292781115	4.48275159443324	ATP6V1A;NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;COX6B1	KEGG_2019_Human	11
Alzheimer disease	3.67309601166308e-06	0.000565656785796114	4.43747127529755	NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;ADAM10;NDUFC1;SDHD;COX6B1;CASP7;NDUFAB1;UQCRFS1;MAPK1;MAPT	KEGG_2019_Human	14
SUMOylation Homo sapiens R-HSA-2990846	0.000565955678401106	0.0481062326640941	4.29311223805307	TOP2A;RAD52;PCNA;PARP1;NUP50;NSMCE1;NUP35;AAAS	Reactome_2016	8
mitochondrial inner membrane (GO:0005743)	2.37324865046111e-10	1.05846889810565e-07	4.29153851655819	NDUFB8;NDUFA11;COX4I1;MRPL19;NDUFA10;MRPL39;HIGD1A;PHB2;MRPL55;MRPL1;MTG2;UQCRFS1;SLC25A42;SLC25A44;SLC25A22;NDUFA3;PDE2A;NDUFC1;SDHD;MRPL45;MRPS18C;MRPL44;COX6B1;DHODH;PINK1;MRPL51;NDUFAB1	GO_Cellular_Component_2018	27
The citric acid (TCA) cycle and respiratory electron transport Homo sapiens R-HSA-1428517	2.78790620318073e-05	0.00853099298173302	4.25102290238589	NDUFB8;SLC16A1;SUCLA2;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;COX6B1	Reactome_2016	12
mitochondrial outer membrane (GO:0005741)	0.000283387806684219	0.0421303205937205	4.24178154825027	PINK1;CYB5R3;SAMM50;PDE2A;TOMM34;MFN1;PHB2;UBA52;BCL2L2	GO_Cellular_Component_2018	9
Nonalcoholic fatty liver disease WP4396	3.17113339121551e-05	0.00748387480326861	4.196170993968	CASP7;NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;CCL2;NDUFC1;SDHD;COX6B1	WikiPathways_2019_Human	12
Th17 cell differentiation	0.000829812863765429	0.0170388241359835	4.05237697236785	CHUK;LCK;IFNGR2;MAPK1;STAT6;FOS;CD247;IL27RA	KEGG_2019_Human	8
Non-alcoholic fatty liver disease (NAFLD)	0.000103550261578839	0.00398668507078532	4.00138229570215	CASP7;NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFAB1;UQCRFS1;NDUFC1;SDHD;COX6B1	KEGG_2019_Human	11
TNF signaling pathway	0.000994545749998884	0.0191450056874785	3.94185760039419	RPS6KA4;CASP7;CHUK;IL15;CCL2;MAPK1;FOS;BIRC2	KEGG_2019_Human	8
PDGF signaling pathway Homo sapiens P00047	0.00111819791426358	0.0313095415993803	3.87146728610143	RPS6KA4;VAV3;CHUK;PLCG2;MAPK1;STAT6;FOS;SOS2	Panther_2016	8
Ras Signaling WP4223	3.92281545219932e-05	0.00617189631146027	3.82938611994816	CHUK;FLT3;PLA2G6;STK4;ETS2;TIAM1;GNG2;PLCG2;GNB4;MAPK1;KRAS;SOS2;FGFR2	WikiPathways_2019_Human	13
AGE-RAGE signaling pathway in diabetic complications	0.00253469439271572	0.0354857214980201	3.7940379403794	COL4A1;PLCG2;CCL2;MAPK1;KRAS;F3;AGT	KEGG_2019_Human	7
Apoptosis	0.0003291603596095	0.00844844922997718	3.79024769268672	CASP7;CHUK;PARP1;LMNA;MAPK1;KRAS;FOS;TUBA4A;CTSC;BIRC2	KEGG_2019_Human	10
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway WP2380	0.000348040927917487	0.0328550635954108	3.76392652815417	VAV3;TIAM1;EGR2;CHUK;CFL1;RHOG;SIRPA;MAPK1;FOS;MAPT	WikiPathways_2019_Human	10
Natural killer cell mediated cytotoxicity	0.000736808175956065	0.0162097798710334	3.723701359151	VAV3;LCK;IFNGR2;PLCG2;MAPK1;PTPN6;KRAS;CD247;SOS2	KEGG_2019_Human	9
Chagas disease (American trypanosomiasis)	0.00299397478422746	0.0368857693416823	3.68353198095088	CHUK;IFNGR2;CCL3;CCL2;MAPK1;FOS;CD247	KEGG_2019_Human	7
Osteoclast differentiation	0.00248586869680104	0.0364594075530819	3.41420737042016	TEC;CHUK;LCK;IFNGR2;PLCG2;SIRPA;MAPK1;FOS	KEGG_2019_Human	8
Huntington disease	0.000257651802644366	0.00721425047404224	3.36998188634736	NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFAB1;NDUFA10;PPIF;UQCRFS1;NDUFC1;SDHD;PPARGC1A;COX6B1	KEGG_2019_Human	12
Retrograde endocannabinoid signaling	0.0017392272624646	0.0281937893073209	3.295978905735	NDUFB8;GNG2;NDUFA11;NDUFA3;NDUFA10;NDUFAB1;GNB4;MAPK1;NDUFC1	KEGG_2019_Human	9
Thermogenesis	0.000105856494377097	0.00362264447423843	3.28488133366182	NDUFB8;NDUFA11;COX4I1;NDUFA3;NDUFA10;NDUFC1;SDHD;COX6B1;NDUFAB1;UQCRFS1;KRAS;PPARGC1A;SOS2;PNPLA2	KEGG_2019_Human	14
FoxO signaling pathway	0.00315591621160501	0.0360008219694201	3.28488133366182	CCND2;CHUK;MAPK1;KRAS;STK4;PCK1;SOS2;ATG12	KEGG_2019_Human	8
Ras signaling pathway	0.000110806779615356	0.00341284881215298	3.27072236239604	CHUK;FLT3;IGF2;PLA2G6;STK4;ETS2;TIAM1;GNG2;PLCG2;GNB4;MAPK1;KRAS;SOS2;FGFR2	KEGG_2019_Human	14
Platelet activation, signaling and aggregation Homo sapiens R-HSA-76002	7.74567359350267e-05	0.0169298294257987	3.21347086988656	VAV3;ACTN1;IGF2;RHOG;TUBA4A;APBB1IP;GNG2;LCK;CFL1;PSAP;PLCG2;GNB4;MAPK1;CD9;PTPN6	Reactome_2016	15
Hemostasis Homo sapiens R-HSA-109582	1.46946224198639e-07	0.000112413861511959	2.94568163072935	SLC3A2;GNG2;RACGAP1;CFL1;PSAP;PLCG2;MFN1;SIRPA;MAPK1;VAV3;CXADR;SLC16A1;ITGA3;ACTN1;PDE2A;ITPK1;IGF2;RHOG;F3;TUBA4A;APBB1IP;RAD51B;F7;SLC7A5;KIF18A;LCK;GNB4;CD9;KRAS;PTPN6	Reactome_2016	30
Pathways in cancer	6.82928317449717e-07	0.000210341921774513	2.8634248606637	RET;NOTCH3;FLT3;MGST2;STK4;CASP7;CCND2;GNG2;PLCG2;MAPK1;STAT6;POLK;JAG2;CHUK;IL15;ITGA3;TXNRD2;IFNGR2;IGF2;FOS;AGT;COL4A1;CCDC6;GNB4;KRAS;SOS2;FGFR2;BIRC2	KEGG_2019_Human	28
Chemokine signaling pathway	0.00286644120815541	0.0367859955046611	2.85266010554842	VAV3;TIAM1;GNG2;CHUK;GNB4;CCL3;CCL2;MAPK1;KRAS;SOS2	KEGG_2019_Human	10
mitochondrion (GO:0005739)	3.3569444371025e-10	7.48598609473858e-08	2.64135194958187	SLC27A1;NDUFA11;PARS2;COX4I1;NDUFA10;CISD1;DCAF8;MRPL39;ABAT;PHB2;CHCHD4;MRPL1;UQCRFS1;MLYCD;SLC25A42;EARS2;PARP1;TOMM34;MUL1;NDUFC1;SDHD;MRPL45;MRPL44;CYP27A1;PPIF;MAPT;CCDC90B;NDUFB8;FECH;MRPL19;HIGD1A;GRAMD4;CYB5R3;SAMM50;MFN1;MAPK1;IARS2;BRD8;PCK1;WWOX;TXNRD2;NDUFA3;DHRS4;DHODH;NUDT9;PINK1;AMACR;SUCLA2;NDUFAB1;DEGS1	GO_Cellular_Component_2018	50
mitochondrial matrix (GO:0005759)	0.000643069100379903	0.0318676465299374	2.63963678597825	NDUFB8;FECH;TXNRD2;ARL2;ABAT;NR3C1;CYP27A1;NUDT9;SUCLA2;PCCA;MTG2;NDUFAB1;PPIF;IARS2;MLYCD	GO_Cellular_Component_2018	15
Axon guidance Homo sapiens R-HSA-422475	9.47770146443111e-05	0.0181261040507245	2.42060673033915	VASP;RET;VAV3;SEMA5A;TRPC4;RHOG;ADAM10;DUSP16;RPS6KA4;APBB1IP;TIAM1;EFNB3;PSMB3;COL4A1;CFL1;MAPK1;EVL;KRAS;UBA52;NEO1;SOS2;FGFR2;PFN2	Reactome_2016	23
Cell Cycle Homo sapiens R-HSA-1640170	0.000370134462305916	0.0353941079580032	2.20249552318845	TOP2A;AHCTF1;PCNA;ANAPC16;AAAS;SMC4;TUBA4A;BABAM1;CENPF;KIF18A;CCND2;MIS18BP1;PSMB3;GORASP2;RUVBL2;NUP50;POLE2;LMNA;MAPK1;NUP35;SYCP3;UBA52;MCM2	Reactome_2016	23
Metabolism of lipids and lipoproteins Homo sapiens R-HSA-556833	0.000573633614926364	0.0461926016230177	2.05616623692792	SLC27A1;INSIG2;PLA2G6;PIK3C2A;FADS2;SPTLC2;PSAP;MLYCD;LDLRAP1;PPARGC1A;LDLR;FADS1;CERS4;PHYH;PCYT2;PTGIS;AGT;CYP27A1;NCOR2;AMACR;PCCA;DEGS1;MVD;ACOT4;PNPLA2	Reactome_2016	25
Metabolism of proteins Homo sapiens R-HSA-392499	1.98404878068287e-05	0.00758898658611197	2.01864216035084	TOP2A;SEMA5A;B4GALT2;PCNA;ARL2;AAAS;ADAMTS10;GALNT10;CHCHD4;SEC61A2;SAMM50;GNG2;MAN1A2;LMNA;TMED3;CCL2;MGAT2;CTSC;SEC11C;EIF2B5;PARP1;GALNT1;NSMCE1;IGF2;ALG12;AGT;TUBA4A;CKAP4;RAD52;F7;NUP50;EEF1A2;GNB4;SRPRB;NUP35;MVD;TGFBI;MFGE8;UBA52;RPS24	Reactome_2016	40
Metabolism Homo sapiens R-HSA-1430728	8.49325235677501e-08	0.000129946761058658	1.93167550124139	B4GALT2;SLC27A1;NDUFA11;PANK1;COX4I1;NDUFA10;NUDT5;PIK3C2A;FADS2;SPTLC2;NAGLU;UQCRFS1;MLYCD;LDLRAP1;FADS1;VKORC1;CERS4;PHYH;PCYT2;PTGIS;ITPK1;DIO1;NDUFC1;CMBL;SDHD;PGD;DCN;COX6B1;CYP27A1;NCOR2;PCCA;NUP50;CHST1;MVD;UBA52;ACOT4;ALDH9A1;NDUFB8;FECH;INSIG2;SDC3;MGST2;ARL2;AAAS;PLA2G6;CYB5R3;GNG2;PSMB3;CARNS1;PSAP;PLCG2;PCK1;PPARGC1A;LDLR;SLC16A1;NDUFA3;MTHFR;AGT;DHODH;NUDT9;AMACR;SUCLA2;NDUFAB1;GNB4;NUP35;DEGS1;RPS24;PNPLA2	Reactome_2016	68
Developmental Biology Homo sapiens R-HSA-1266738	0.000728028930801083	0.048429750614159	1.93080811215237	RET;SEMA5A;PCSK6;DUSP16;RPS6KA4;EFNB3;PSMB3;CFL1;MAPK1;PCK1;PPARGC1A;NEO1;VASP;VAV3;EGR2;TRPC4;RHOG;ADAM10;APBB1IP;NCOR2;TIAM1;COL4A1;EVL;KRAS;UBA52;SOS2;FGFR2;PFN2	Reactome_2016	28
