Supplemental Table S3: Fisher’s exact test (FET) enrichment results for the 162 DEGs
Term: Functional annotation (see Fig 2).
P.value: The nominal p-value
Adjusted.P.value: the FDR
Odds.Ratio: The odds ratio
Genes: The genes associated with the functional annotation
source: The source of the functional annotation
nge: The number of genes associated with the functional annotation

Term	P.value	Adjusted.P.value	Odds.Ratio	Genes	source	nge
bile acid secretion (GO:0032782)	0.000957418522034545	0.81428445299038	41.1522633744856	ABCC3;ABCB11	GO_Biological_Process_2018	2
ATPase-coupled anion transmembrane transporter activity (GO:0043225)	0.0001087668014741	0.125190588496689	30.8641975308642	ABCC3;ABCC9;ABCB11	GO_Molecular_Function_2018	3
positive regulation of p38MAPK cascade (GO:1900745)	0.000389267163635055	0.993215168014843	20.5761316872428	GADD45B;LEP;GADD45G	GO_Biological_Process_2018	3
unsaturated fatty acid metabolic process (GO:0033559)	2.75750219664816e-05	0.140715337094955	14.0291806958474	ELOVL3;PLA2G4A;DEGS1;FADS1;MGLL	GO_Biological_Process_2018	5
ABC transporters	0.000477124075910814	0.146954215380531	10.9739368998628	ABCC3;DEFB1;ABCC9;ABCB11	KEGG_2019_Human	4
icosanoid metabolic process (GO:0006690)	0.000519292905289949	0.883317231898203	10.7353730542136	GPX1;PLA2G4A;FADS1;MGLL	GO_Biological_Process_2018	4
Ovarian steroidogenesis	0.000661660807294712	0.101895764323386	10.0781053162006	LHCGR;HSD17B1;AKR1C3;PLA2G4A	KEGG_2019_Human	4
glutathione metabolic process (GO:0006749)	0.000661660807294712	0.844113774906229	10.0781053162006	GSTK1;GPX1;ALDH5A1;MGST1	GO_Biological_Process_2018	4
blood circulation (GO:0008015)	0.000714698274542265	0.729421058997835	9.87654320987654	GPX1;NPY5R;ITGB1BP1;TRDN	GO_Biological_Process_2018	4
Ion homeostasis Homo sapiens R-HSA-5578775	0.000770674279277596	0.235826329458944	9.68288549987896	ITPR2;ABCC9;ATP1A2;TRDN	Reactome_2016	4
Selenium Micronutrient Network WP15	0.000672915418987971	0.317616077762322	7.17772035601493	PRDX3;GPX1;SAA4;SAA1;SAA2	WikiPathways_2019_Human	5
Cardiac conduction Homo sapiens R-HSA-5576891	0.000116767200935027	0.0595512724768635	6.40146319158665	KCND2;KCNIP3;ITPR2;ABCC9;ATP1A2;TRDN;HIPK2	Reactome_2016	7
Muscle contraction Homo sapiens R-HSA-397014	0.000201132530656576	0.0769331929761403	5.03905265810028	KCND2;KCNIP3;ITGA1;ITPR2;ABCC9;ATP1A2;TRDN;HIPK2	Reactome_2016	8
Metabolism of lipids and lipoproteins Homo sapiens R-HSA-556833	9.32329770174908e-05	0.0713232274183805	2.99743344761048	ABCC3;ASAH1;LPGAT1;GPX1;ELOVL3;AKR1C3;PLA2G4A;ABCB11;AACS;EHHADH;HSD17B1;DEGS1;FADS1;MGLL;TNFRSF21;DECR1	Reactome_2016	16
Metabolism Homo sapiens R-HSA-1430728	4.36803536601144e-08	6.68309410999751e-05	2.52348784843544	ASAH1;LPGAT1;MGST1;ADK;ITPR2;GLYAT;PYGL;HNMT;ABCB11;AACS;PAPSS2;ALAD;CKMT2;PPP2R1B;HSD17B1;PHGDH;FADS1;DECR1;IDH3A;ABCC3;GSTK1;PDHX;GPX1;ELOVL3;AKR1C3;PLA2G4A;QDPR;SLC25A16;RBP4;POR;SCO1;EHHADH;DEGS1;B4GALT6;ADA;MGLL;TNFRSF21;CES1;RAPGEF4	Reactome_2016	39
