Supplemental Table S8: Functions associated with transcription factors overlapping sex-specific
eQTLs.
Term: Functional annotation.
P.value: The nominal p-value
Adjusted.P.value: the FDR
Odds.Ratio: The odds ratio
Genes: The genes associated with the functional annotation
source: The source of the functional annotation
nge: The number of genes associated with the functional annotation

Term	P.value	Adjusted.P.value	Odds.Ratio	Genes	source	nge
White fat cell differentiation WP4149	4.79230648695221e-28	1.13098433092072e-25	66.40625	STAT5A;CEBPA;STAT5B;SREBF1;CEBPB;EGR2;EBF1;NR1H3;RORA;NR3C1;GATA2;KLF4;FOXO1;KLF5;MECOM;DDIT3;PPARG	WikiPathways_2019_Human	17
Prion disease pathway WP3995	1.67020259912325e-19	1.57667125357235e-17	49.2424242424242	MEF2C;SPI1;TBP;STAT3;EBF1;CTCF;PAX5;POU2F2;ELK1;NFKB1;BATF;RXRA;RFX5	WikiPathways_2019_Human	13
Nuclear Receptors WP170	2.01666184392316e-20	2.37966097582933e-18	46.0526315789474	ESRRA;ESRRB;NR2F1;NR1H3;RORA;NR3C1;NR2C2;ESR1;ESR2;AR;RXRA;NR5A2;HNF4A;PPARG	WikiPathways_2019_Human	14
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705)	7.27677246553947e-29	5.58371007189062e-27	41.015625	MYOG;MEF2A;CEBPA;MEF2C;CEBPB;JUN;SPI1;FOXF2;SRF;FOXH1;ESRRB;RFX1;USF2;RELA;NFKB1;USF1;NR5A2;MYOD1;BHLHE40;REL;SOX9	GO_Molecular_Function_2018	21
Nuclear Receptor transcription pathway Homo sapiens R-HSA-383280	4.4776855819801e-20	3.42542947021478e-17	36.7647058823529	ESRRA;ESRRB;HNF4G;NR2F1;NR1H3;RORA;NR3C1;NR2C2;ESR1;ESR2;AR;NR5A2;RXRA;HNF4A;PPARG	Reactome_2016	15
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	1.53466854506035e-88	5.88801165121489e-86	31.25	FOXA1;GFI1;FOXI1;HNF4G;PRDM1;CTCF;NR3C1;ETS1;ELK1;BACH1;DUX4;YY1;ELK4;MYC;HNF4A;MYB;SOX9;TEAD1;GABPA;MEF2A;MEF2C;TCF12;EBF1;EN1;HNF1A;FOS;SREBF2;THAP1;ELF1;DDIT3;IRF1;HAND1;ERG;MZF1;TP53;CEBPB;HLF;MAX;PLAG1;SRF;CRX;NR2C2;GATA1;RELA;NFIL3;HSF1;E2F4;SMAD2;TFAP2A;ZNF143;JUN;EGR2;SMAD4;TFAP2C;STAT3;NR2F1;KLF4;ESR1;USF2;USF1;FOSL2;BATF;FOSL1;REST;KLF5;SP2;SP1;BHLHE40;TCF3;INSM1	GO_Molecular_Function_2018	70
core promoter proximal region sequence-specific DNA binding (GO:0000987)	6.29356776098451e-87	1.81097412322329e-84	31.0251798561151	FOXI1;HNF4G;PRDM1;CTCF;NR3C1;ETS1;ELK1;DUX4;YY1;ELK4;MYC;MYB;JUNB;TEAD1;GABPA;MEF2A;MYOG;MEF2C;TBP;TCF12;RFX2;EN1;RFX1;FOS;SREBF2;THAP1;ELF1;DDIT3;IRF1;MYOD1;RFX5;HAND1;ERG;MZF1;TP53;PLAG1;SRF;CRX;NR2C2;RELA;HSF1;E2F4;SMAD2;TFAP2A;ZNF143;NFE2;TCF7L2;JUN;EGR2;SMAD4;SMAD3;JUND;STAT1;STAT3;NR2F1;KLF4;ESR1;USF2;USF1;FOSL2;BATF;KLF1;FOSL1;KLF5;SP2;SP1;TCF3;INSM1;FOXA2	GO_Molecular_Function_2018	69
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078)	1.66878190223825e-29	1.37197712105444e-27	30.9278350515464	TFAP2A;TFAP2C;CEBPB;MAX;GFI1;NR2F1;EN1;PRDM1;CTCF;BACH1;GATA1;SREBF2;RELA;THAP1;YY1;REST;SP2;NFIL3;BHLHE40;HAND1;HSF1;TCF3;INSM1;MZF1	GO_Molecular_Function_2018	24
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	1.09119256614946e-52	1.25596264363803e-50	30.7142857142857	FOXA1;HLF;PLAG1;SRF;FOXI1;HNF4G;CRX;NR3C1;NR2C2;ETS1;ELK1;DUX4;RELA;ELK4;MYC;HNF4A;MYB;SOX9;E2F4;GABPA;MEF2A;SMAD2;TFAP2A;ZNF143;MEF2C;EGR2;SMAD4;TFAP2C;TCF12;STAT3;EBF1;HNF1A;KLF4;ESR1;USF2;USF1;ELF1;KLF5;SP1;DDIT3;IRF1;ERG;MZF1	GO_Molecular_Function_2018	43
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	1.13564860906936e-79	2.61426309807767e-77	30.5343511450382	FOXI1;HNF4G;PRDM1;CTCF;NR3C1;ETS1;ELK1;DUX4;YY1;ELK4;MYC;MYB;JUNB;GABPA;MEF2A;MYOG;MEF2C;TCF12;RFX2;EN1;RFX1;FOS;SREBF2;THAP1;ELF1;DDIT3;IRF1;MYOD1;RFX5;HAND1;ERG;MZF1;TP53;PLAG1;SRF;CRX;NR2C2;RELA;HSF1;E2F4;SMAD2;TFAP2A;ZNF143;TCF7L2;JUN;EGR2;SMAD4;SMAD3;JUND;STAT1;STAT3;NR2F1;ESR1;USF2;USF1;FOSL2;BATF;FOSL1;KLF5;SP2;SP1;TCF3;INSM1;FOXA2	GO_Molecular_Function_2018	64
nuclear transcription factor complex (GO:0044798)	6.7394795585712e-21	6.01161576624551e-19	29.9295774647887	CEBPA;NFYA;MAX;NFYB;TCF12;STAT3;NR1H3;RORA;GATA4;PBX1;NR5A2;RXRA;HAND1;PPARG;E2F3;TCF3;E2F6	GO_Cellular_Component_2018	17
core promoter binding (GO:0001047)	7.82110557714372e-28	5.29534854076025e-26	29.639175257732	MYOG;TFAP2C;SPI1;TBP;NFYA;STAT1;ESRRB;RORA;NR3C1;GATA1;ESR1;ESR2;RUNX1;ELK4;REST;SP1;MYOD1;E2F1;PPARG;E2F3;SOX9;INSM1;TP53	GO_Molecular_Function_2018	23
activating transcription factor binding (GO:0033613)	1.34367087228693e-19	8.59202874445701e-18	29.4117647058824	MEF2A;SMAD2;MEF2C;JUN;EGR2;SMAD3;SRF;GATA4;FOS;RELA;HNF4A;MYC;BHLHE40;PPARG;GABPA;NFE2L2	GO_Molecular_Function_2018	16
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980)	7.08281342442965e-15	3.26092730060741e-13	28.8461538461538	YY1;JUN;SPI1;NR5A2;CDX2;NFYA;NFYB;ESRRB;REL;BACH1;RELA;NFKB1	GO_Molecular_Function_2018	12
Adipogenesis WP236	4.29979319768537e-34	2.02950238930749e-31	27.8846153846154	CEBPA;CEBPB;RORA;GATA4;NR3C1;GATA2;FOXO1;RXRA;E2F1;STAT6;E2F4;MEF2A;STAT5A;STAT5B;SREBF1;MEF2C;EGR2;SMAD3;STAT1;STAT2;STAT3;EBF1;NR2F1;NR1H3;HNF1A;KLF5;SP1;DDIT3;PPARG	WikiPathways_2019_Human	29
IL-4 Signaling Pathway WP395	1.16115625469716e-14	6.85082190271323e-13	27.7777777777778	STAT5A;CEBPA;STAT5B;CEBPB;NFIL3;STAT1;STAT3;STAT6;FOS;ELK1;RELA;NFKB1	WikiPathways_2019_Human	12
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	2.12255684112423e-75	3.49008989161999e-73	27.7288732394366	FOXA1;FOXI1;HNF4G;RORA;NR3C1;ETS1;ELK1;DUX4;ELK4;MYC;HNF4A;MYB;SOX9;GABPA;MEF2A;MYOG;MEF2C;TCF12;EBF1;HNF1A;RUNX1;ELF1;DDIT3;IRF1;MYOD1;RFX5;ERG;MZF1;TP53;CEBPA;HLF;PLAG1;SRF;CRX;GATA4;GATA2;NR2C2;GATA1;RELA;NHLH1;E2F3;STAT6;E2F4;SMAD2;TFAP2A;ZNF143;EGR2;SMAD4;TFAP2C;FOXF2;ESRRB;STAT3;KLF4;ESR1;USF2;NFKB1;USF1;FOSL2;KLF5;LHX3;SP1;MAFF;REL	GO_Molecular_Function_2018	63
enhancer sequence-specific DNA binding (GO:0001158)	8.35614323217721e-17	4.57996231439808e-15	27.34375	JUN;SPI1;CDX2;NFYA;NFYB;ESRRB;GATA2;BACH1;RELA;NFKB1;YY1;NR5A2;REL;SOX9	GO_Molecular_Function_2018	14
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.33238258197219e-125	3.83557235184999e-122	27.1739130434783	SPI1;FOXI1;RORA;PRDM1;NR3C1;ETS1;ELK1;BACH1;DUX4;YY1;ELK4;SOX3;MYC;MYB;JUNB;MEF2A;MEF2C;RFX2;HNF1B;RFX1;HNF1A;THAP1;RUNX1;DDIT3;RFX5;ERG;MZF1;TP53;MAX;GATA4;GATA2;GATA1;NHLH1;SMAD2;TFAP2A;ZNF143;EGR1;JUN;EGR2;SMAD4;TFAP2C;SMAD3;JUND;FOXF2;ESRRB;NR2F1;ESR1;NFKB1;PBX1;FOSL2;FOSL1;SP2;SP1;REL;TCF3;HNF4G;CTCF;GABPA;MYOG;FOXD3;SREBF1;TCF12;EN1;PAX6;FOS;SREBF2;ELF1;NR5A2;TAL1;IRF1;MYOD1;HAND1;PPARG;CEBPB;HLF;PLAG1;SRF;CRX;NR2C2;RELA;RXRA;NFIL3;HSF1;E2F3;STAT6;E2F4;E2F6;TCF7L2;CDX2;NFYA;STAT1;NFYB;STAT3;NR1H3;USF2;USF1;BATF;KLF5;INSM1;FOXA2	GO_Molecular_Function_2018	100
regulatory region DNA binding (GO:0000975)	7.6581577551747e-56	9.79393286245119e-54	26.7857142857143	FOXA1;CEBPA;GFI1;SRF;FOXI1;GATA4;CTCF;RELA;SOX2;YY1;RXRA;HNF4A;MYB;TEAD1;GABPA;MEF2A;TFAP2A;TCF7L2;MEF2C;JUN;EGR2;SMAD4;SMAD3;JUND;TBP;NFYA;NFYB;FOXH1;TCF12;STAT3;NR1H3;HNF1A;FOS;KLF4;NFKB1;RUNX1;KLF1;REST;NR5A2;SP1;TAL1;DDIT3;HAND1;PPARG;MZF1;TP53;NFE2L2;FOXA2	GO_Molecular_Function_2018	48
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001227)	1.2195733715026e-37	1.07979150046115e-35	25.9433962264151	CEBPB;MAX;GFI1;PRDM1;CTCF;BACH1;GATA1;RELA;YY1;NFIL3;HSF1;E2F1;E2F6;TFAP2A;FOXD3;TFAP2C;ZNF263;CDX2;NR2F1;EN1;NFKB1;SREBF2;POU5F1;THAP1;REST;ZEB1;SP2;BHLHE40;HAND1;MAFK;TCF3;INSM1;MZF1	GO_Molecular_Function_2018	33
RNA polymerase II transcription factor binding (GO:0001085)	1.48725253681947e-28	1.0698922936745e-26	25.8264462809917	SPI1;SRF;GATA4;GATA2;ELK1;GATA1;YY1;HNF4A;TEAD1;MEF2A;TCF7L2;MEF2C;EGR2;JUN;SMAD3;STAT3;FOS;KLF4;GFI1B;LHX3;SP1;TAL1;BHLHE40;TP53;NFE2L2	GO_Molecular_Function_2018	25
core promoter sequence-specific DNA binding (GO:0001046)	1.7576074971332e-17	1.01150311460016e-15	25.6849315068493	TFAP2A;NFYA;STAT1;RORA;PAX6;FOS;GATA1;ESR1;ESR2;SOX3;REST;SP1;PPARG;SOX9;TP53	GO_Molecular_Function_2018	15
RNA polymerase II transcription factor complex (GO:0090575)	5.40882336641287e-34	8.0411174047338e-32	25.5102040816327	CEBPA;CEBPB;MAX;RORA;GATA4;RXRA;E2F1;E2F3;JUNB;TEAD1;E2F6;SMAD2;SMAD4;JUN;JUND;TBP;NFYA;NFYB;FOXH1;TCF12;STAT3;NR1H3;FOS;PBX1;NR5A2;DDIT3;HAND1;PPARG;TCF3;TP53	GO_Cellular_Component_2018	30
transcription regulatory region DNA binding (GO:0044212)	3.08706272575624e-89	1.77660459867271e-86	25.4010695187166	FOXA1;SPI1;GFI1;FOXI1;RORA;CTCF;NR3C1;DUX4;SOX2;YY1;ELK4;MYC;HNF4A;MYB;SOX9;TEAD1;GABPA;MEF2A;MYOG;SREBF1;MEF2C;TBP;FOXH1;TCF12;HNF1A;FOS;POU5F1;SREBF2;RUNX1;ZEB1;NR5A2;TAL1;DDIT3;MYOD1;HAND1;PPARG;MZF1;TP53;CEBPA;MAX;SRF;GATA4;GATA1;RELA;RXRA;E2F1;E2F3;SMAD2;TFAP2A;EGR1;NFE2;TCF7L2;JUN;EGR2;SMAD4;TFAP2C;SMAD3;JUND;NFYA;STAT1;NFYB;ESRRB;STAT3;NR1H3;KLF4;ESR1;ESR2;NFKB1;KLF1;REST;SP1;BHLHE40;TCF3;INSM1;NFE2L2;FOXA2	GO_Molecular_Function_2018	76
transcription regulatory region sequence-specific DNA binding (GO:0000976)	5.3698667572412e-66	7.72589579698077e-64	24.8287671232877	RORA;DUX4;YY1;SOX9;TEAD1;MEF2A;MYOG;FOXD3;SREBF1;MEF2C;TBP;HNF1B;HNF1A;POU5F1;RUNX1;NR5A2;TAL1;DDIT3;MYOD1;PPARG;TP53;CEBPB;HLF;MAX;SRF;GATA4;GATA2;NR2C2;GATA1;RELA;RXRA;NFIL3;NHLH1;E2F3;STAT6;E2F6;TFAP2A;EGR1;NFE2;SMAD4;TFAP2C;SMAD3;FOXF2;CDX2;NFYA;ESRRB;NR1H3;KLF4;ESR1;ESR2;NFKB1;PBX1;FOSL2;KLF1;REST;SP1;REL;NFE2L2	GO_Molecular_Function_2018	58
RNA polymerase II regulatory region DNA binding (GO:0001012)	1.01959452891223e-41	9.77961085648311e-40	23.6318407960199	CEBPB;HLF;MAX;SRF;RORA;GATA4;GATA2;NR2C2;GATA1;RELA;RXRA;NFIL3;NHLH1;E2F3;STAT6;E2F6;MEF2A;TFAP2A;MYOG;EGR1;FOXD3;SREBF1;MEF2C;TFAP2C;FOXF2;CDX2;NR1H3;HNF1B;HNF1A;NFKB1;PBX1;RUNX1;FOSL2;SP1;TAL1;MYOD1;REL;PPARG	GO_Molecular_Function_2018	38
PDGF signaling pathway Homo sapiens P00047	3.58023289175012e-20	4.00986083876014e-18	21.2053571428571	STAT5A;STAT5B;JUN;STAT1;SRF;STAT2;STAT3;FOS;ETS1;ELK1;FLI1;ELK4;ELF1;MYC;ELF5;STAT4;STAT6;ERG;GABPA	Panther_2016	19
Inflammatory bowel disease (IBD)	3.74496044172891e-12	1.44180977006563e-10	21.1538461538462	SMAD2;JUN;MAF;SMAD3;STAT1;STAT3;STAT4;RORA;STAT6;RELA;NFKB1	KEGG_2019_Human	11
Oncostatin M Signaling Pathway WP2374	3.74496044172891e-12	1.17841421899736e-10	21.1538461538462	STAT5B;EGR1;CEBPB;JUND;STAT1;STAT3;FOS;JUNB;TP53;RELA;NFKB1	WikiPathways_2019_Human	11
AGE/RAGE pathway WP2324	4.46327067821735e-12	1.31666485007412e-10	20.8333333333333	SMAD2;STAT5A;STAT5B;JUN;SMAD3;STAT1;SP1;STAT3;RELA;FOXO1;NFKB1	WikiPathways_2019_Human	11
Chronic myeloid leukemia	9.03170918851421e-13	3.97395204294625e-11	19.7368421052632	STAT5A;STAT5B;SMAD4;SMAD3;MECOM;MYC;E2F1;E2F3;TP53;RELA;NFKB1;RUNX1	KEGG_2019_Human	12
Prolactin signaling pathway	8.74862660027538e-12	2.99397443653869e-10	19.6428571428571	STAT5A;STAT5B;STAT1;IRF1;ELF5;STAT3;FOS;ESR1;RELA;NFKB1;ESR2	KEGG_2019_Human	11
nuclear chromatin (GO:0000790)	3.59905648204934e-39	1.605179190994e-36	19.2687747035573	SPI1;MAX;SRF;RELA;YY1;RXRA;MYC;E2F1;E2F4;JUNB;TP63;GABPA;MEF2A;SMAD2;FOXD3;TCF7L2;MEF2C;JUN;SMAD4;SMAD3;JUND;TBP;STAT1;FOXH1;TCF12;STAT3;NR1H3;PAX6;KLF4;ESR1;RUNX2;USF1;KLF1;SP1;TAL1;IRF1;MYOD1;TCF3;TP53	GO_Cellular_Component_2018	39
Transcriptional regulation of white adipocyte differentiation Homo sapiens R-HSA-381340	1.46055423925083e-12	4.46929597210755e-10	18.9873417721519	SREBF1;CEBPA;CEBPB;EGR2;RXRA;KLF5;EBF1;PPARG;KLF4;SREBF2;RELA;NFKB1	Reactome_2016	12
Interleukin signaling pathway Homo sapiens P00036	1.76434960964005e-13	9.88035781398431e-12	18.8953488372093	STAT5A;STAT5B;SPI1;STAT1;SRF;STAT2;STAT3;FOS;ELK1;ELK4;MYC;STAT4;STAT6	Panther_2016	13
Transcriptional misregulation in cancer	7.85929878204325e-28	2.42066402486932e-25	18.8172043010753	CEBPA;CEBPB;SPI1;MAX;FOXO1;RELA;ELK4;HOXA9;RXRA;MYC;MEF2C;PAX5;RUNX2;FLI1;NFKB1;PBX1;RUNX1;MEIS1;MAF;ZEB1;BCL6;SP1;DDIT3;REL;PPARG;ERG;TCF3;TP53	KEGG_2019_Human	28
Prolactin Signaling Pathway WP2037	2.22229074589331e-11	5.24460616030821e-10	18.0921052631579	STAT5A;STAT5B;JUN;STAT1;MYC;IRF1;STAT3;FOS;ELK1;RELA;NFKB1	WikiPathways_2019_Human	11
sequence-specific double-stranded DNA binding (GO:1990837)	6.44841424005484e-16	3.09255199595963e-14	17.8571428571429	MEF2A;TFAP2A;EGR1;NFE2;MEF2C;SRF;NR1H3;RORA;DUX4;GATA1;NFKB1;POU5F1;NR5A2;DDIT3;PPARG;NFE2L2	GO_Molecular_Function_2018	16
Th17 cell differentiation	7.22512660494846e-15	4.45067798864825e-13	17.5233644859813	SMAD2;STAT5A;STAT5B;SMAD4;JUN;SMAD3;STAT1;STAT3;RORA;FOS;NFKB1;RELA;RUNX1;RXRA;STAT6	KEGG_2019_Human	15
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways WP706	2.99714684272844e-21	4.71551103255941e-19	17.4050632911392	EGR1;MEF2C;JUN;CEBPB;NFYA;EN1;RORA;CTCF;NR3C1;GATA2;POU2F2;NFKB1;ESR2;PBX1;POU5F1;SOX2;AR;REST;SP1;MYB;BHLHE40;TCF3	WikiPathways_2019_Human	22
Mesodermal Commitment Pathway WP2857	3.38626034653871e-19	2.66385813927712e-17	17.0068027210884	FOXA1;SMAD2;SMAD4;SMAD3;SRF;FOXH1;PAX6;KLF4;PBX1;POU5F1;ELK4;SOX2;MEIS1;KLF5;HNF4A;BHLHE40;HAND1;TEAD1;NFE2L2;FOXA2	WikiPathways_2019_Human	20
chromatin (GO:0000785)	8.04351122415658e-38	1.79370300298692e-35	16.8918918918919	SPI1;MAX;SRF;RELA;YY1;RXRA;MYC;E2F1;E2F4;JUNB;TP63;GABPA;MEF2A;SMAD2;FOXD3;TCF7L2;MEF2C;JUN;SMAD4;SMAD3;JUND;TBP;STAT1;FOXH1;TCF12;STAT3;NR1H3;PAX6;KLF4;ESR1;RUNX2;USF1;KLF1;MAF;SP1;TAL1;IRF1;MYOD1;TCF3;TP53	GO_Cellular_Component_2018	40
TGF-beta Signaling Pathway WP366	4.62194077127784e-16	3.11650863434734e-14	16.0984848484848	MEF2A;SMAD2;MEF2C;SMAD4;JUN;SMAD3;JUND;FOXH1;FOS;ETS1;RUNX2;ZEB1;SP1;MYC;E2F4;JUNB;TP53	WikiPathways_2019_Human	17
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) WP2840	1.00778994078899e-10	2.06816022631479e-09	15.8045977011494	FOXQ1;SOX2;JUN;EGR2;SMAD4;SOX9;FOS;TCF3;NR3C1;TP63;NFKB1	WikiPathways_2019_Human	11
sequence-specific DNA binding (GO:0043565)	8.25111809807247e-45	8.63366993716492e-43	15.5456852791878	FOXI1;RORA;CTCF;SOX2;YY1;MECOM;MYB;TEAD1;TP63;MEF2A;MYOG;MEF2C;FOXH1;ZBTB33;POU5F1;THAP1;NR5A2;RFX5;PPARG;HLF;SRF;GATA4;NR2C2;GATA1;FOXO1;RXRA;HSF1;E2F1;E2F3;TFAP2A;ESRRA;EGR1;NFE2;TCF7L2;ZNF263;SMAD4;SMAD3;FOXF2;ESRRB;NR2F1;POU2F2;USF2;USF1;BATF;LHX3;BCL6;SP1;MAFF;MAFK	GO_Molecular_Function_2018	49
B Cell Receptor Signaling Pathway WP23	1.79707333490017e-11	4.46430849512043e-10	15.4639175257732	MEF2C;JUN;BCL6;MAX;MYC;REL;E2F3;ETS1;ELK1;FOXO1;NFKB1;RELA	WikiPathways_2019_Human	12
Hepatitis B	2.75839529325851e-18	2.12396437580905e-16	15.3374233128834	SMAD2;STAT5A;STAT5B;JUN;EGR2;SMAD4;SMAD3;STAT1;STAT2;STAT3;FOS;ELK1;NFKB1;RELA;MYC;STAT4;E2F1;E2F3;STAT6;TP53	KEGG_2019_Human	20
AGE-RAGE signaling pathway in diabetic complications	2.59413134849026e-11	7.26356777577272e-10	15	SMAD2;STAT5A;STAT5B;EGR1;SMAD4;JUN;SMAD3;STAT1;STAT3;FOXO1;NFKB1;RELA	KEGG_2019_Human	12
transcription initiation from RNA polymerase II promoter (GO:0006367)	3.76905284586378e-17	1.13138098073193e-14	14.84375	ESRRA;TBP;ESRRB;NR2F1;HNF4G;NR1H3;RORA;NR3C1;NR2C2;ESR1;RUNX2;ESR2;NR5A2;RXRA;HNF4A;PPARG;E2F3;SOX9;TEAD1	GO_Biological_Process_2018	19
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	9.71104794537878e-97	2.47777388326339e-93	14.7405660377358	FOXA1;SPI1;FOXI1;RORA;NR3C1;ETS1;ELK1;DUX4;SOX2;ELK4;MYC;MYB;SOX9;JUNB;TP63;MEF2A;MEF2C;FOXH1;EBF1;HNF1B;HNF1A;RUNX2;RUNX1;DDIT3;RFX5;ERG;MZF1;TP53;GATA4;GATA2;GATA1;FOXO1;NHLH1;SMAD2;TFAP2A;ESRRA;ZNF143;EGR1;STAT5B;JUN;EGR2;SMAD4;TFAP2C;SMAD3;JUND;FOXF2;ESRRB;ESR1;NFKB1;PBX1;FOSL2;LHX3;SP1;MAFF;REL;TCF3;NFE2L2;HNF4G;MECOM;HNF4A;TEAD1;GABPA;MYOG;FOXD3;SREBF1;TCF12;PAX6;FOS;POU5F1;SREBF2;ELF1;NR5A2;TAL1;IRF1;MYOD1;HAND1;PPARG;CEBPA;CEBPB;HLF;PLAG1;SRF;CRX;NR2C2;RELA;RXRA;HSF1;E2F1;E2F3;STAT6;E2F4;TCF7L2;STAT1;STAT3;NR1H3;KLF4;USF2;USF1;KLF5;FOXA2	GO_Biological_Process_2018	100
positive regulation of nucleic acid-templated transcription (GO:1903508)	4.56822338624595e-53	3.3302348485733e-50	14.691235059761	SPI1;RORA;CTCF;ETS1;ELK1;SOX2;MECOM;MYC;HNF4A;MYB;SOX9;TEAD1;TP63;MEF2C;FOXH1;HNF1B;PAX6;HNF1A;FOS;RUNX2;RUNX1;ELF1;NR5A2;TAL1;DDIT3;IRF1;PPARG;TP53;GATA4;GATA1;FOXO1;RELA;E2F1;SMAD2;TFAP2A;EGR1;NFE2;JUN;EGR2;SMAD4;SMAD3;FOXF2;NFYA;STAT1;ESRRB;STAT3;NR1H3;KLF4;ESR1;ESR2;FLI1;NFKB1;KLF1;REST;LHX3;SP1;TCF3;NFE2L2;FOXA2	GO_Biological_Process_2018	59
transcription, DNA-templated (GO:0006351)	6.94333795141865e-36	3.54318535660894e-33	14.3960674157303	CEBPA;CEBPB;HLF;MAX;SRF;GATA4;NR3C1;GATA2;GATA1;HSF1;E2F1;GABPA;MEF2A;ZNF143;EGR1;NFE2;EGR2;TBP;CDX2;NFYA;PAX6;PAX5;POU2F2;KLF4;ESR1;USF2;NFKB1;POU5F1;USF1;THAP1;FOSL1;GFI1B;MAF;KLF5;IRF1;ELF5;MAFF;HAND1;TCF3;TP53;NFE2L2	GO_Biological_Process_2018	41
transcription from RNA polymerase II promoter (GO:0006366)	2.31233174033249e-48	1.47497860886458e-45	14.1752577319588	SPI1;HNF4G;RORA;NR3C1;ETS1;HNF4A;SOX9;TEAD1;GABPA;MYOG;TBP;PAX6;PAX5;RUNX2;POU5F1;MAF;NR5A2;DDIT3;IRF1;ELF5;HAND1;PPARG;CEBPA;CEBPB;HLF;MAX;SRF;GATA4;NR2C2;GATA1;RELA;RXRA;E2F3;ESRRA;ZNF143;EGR1;EGR2;CDX2;NFYA;ESRRB;NR2F1;NR1H3;POU2F2;KLF4;ESR1;USF2;ESR2;NFKB1;USF1;FOSL1;GFI1B;KLF5;SP1;MAFF;NFE2L2	GO_Biological_Process_2018	55
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	1.68670394546562e-55	1.72145004674222e-52	13.9380530973451	GFI1;PRDM1;CTCF;NR3C1;BACH1;SOX2;YY1;ELK4;MYC;MYB;SOX9;JUNB;TP63;MEF2A;FOXD3;MEF2C;EN1;POU5F1;SREBF2;THAP1;ZEB1;DDIT3;HAND1;PPARG;MZF1;TP53;CEBPB;MAX;SRF;GATA1;RELA;RXRA;NFIL3;HSF1;E2F1;E2F6;SMAD2;TFAP2A;TCF7L2;ZNF263;JUN;SMAD4;TFAP2C;SMAD3;JUND;CDX2;STAT1;STAT3;NR2F1;NR1H3;KLF4;ESR1;ESR2;NFKB1;GFI1B;REST;SP2;BCL6;BHLHE40;REL;MAFK;TCF3;INSM1	GO_Biological_Process_2018	63
Human T-cell leukemia virus 1 infection	1.3915896295568e-20	1.42869868634498e-18	13.6986301369863	SMAD2;STAT5A;EGR1;STAT5B;JUN;EGR2;SMAD4;SPI1;SMAD3;TBP;NFYB;SRF;FOS;ETS1;ELK1;NFKB1;RELA;ELK4;FOSL1;MYC;E2F1;E2F3;TCF3;TP53	KEGG_2019_Human	24
Signaling pathways regulating pluripotency of stem cells	3.75884504337646e-13	1.92954045559992e-11	13.4892086330935	SMAD2;SMAD4;SMAD3;ESRRB;STAT3;PAX6;HNF1A;KLF4;POU5F1;SOX2;MEIS1;REST;MYC;HAND1;TCF3	KEGG_2019_Human	15
Wnt Signaling Pathway and Pluripotency WP399	5.7848053784465e-10	9.7515290665241e-09	13.4803921568627	SOX2;FOSL1;FOXD3;TCF7L2;JUN;NFYA;MYC;ESRRB;ZBTB33;TP53;POU5F1	WikiPathways_2019_Human	11
Endoderm Differentiation WP2853	4.64709204837879e-13	2.19342744683479e-11	13.2978723404255	FOXA1;SMAD2;SMAD4;SMAD3;STAT1;FOXH1;HNF1B;GATA4;NR3C1;FOXO1;PBX1;POU5F1;ELK4;SOX2;FOXA2	WikiPathways_2019_Human	15
positive regulation of cell differentiation (GO:0045597)	8.90763821822819e-17	2.52531543486769e-14	12.8865979381443	MEF2A;SMAD2;MYOG;MEF2C;JUN;SMAD4;CEBPB;SMAD3;JUND;SRF;RUNX2;NFKB1;MYOD1;PPARG;SOX9;TCF3;INSM1;SOX6;JUNB;TP63	GO_Biological_Process_2018	20
DNA-templated transcription, initiation (GO:0006352)	6.49206688233428e-16	1.74363248950273e-13	12.7688172043011	ESRRA;TBP;ESRRB;NR2F1;HNF4G;NR1H3;RORA;NR3C1;NR2C2;ESR1;RUNX2;ESR2;NR5A2;RXRA;HNF4A;PPARG;E2F3;SOX9;TEAD1	GO_Biological_Process_2018	19
DNA binding (GO:0003677)	5.39120781523374e-79	1.03421336588901e-76	12.5979843225084	FOXA1;FOXI1;RORA;CTCF;ETS1;SOX2;YY1;ELK4;SOX3;MECOM;MYC;HNF4A;MYB;SOX6;JUNB;TEAD1;TP63;GABPA;MEF2A;MYOG;SREBF1;MEF2C;FOXH1;RFX2;PAX4;PAX6;ZBTB33;HNF1A;POU5F1;THAP1;NR5A2;DDIT3;IRF1;RFX5;PPARG;ERG;TP53;CEBPA;CEBPB;HLF;MAX;SRF;GATA4;NR2C2;GATA1;FOXO1;RELA;RXRA;NFIL3;HLTF;HSF1;E2F1;E2F3;E2F4;E2F6;SMAD2;TFAP2A;ESRRA;EGR1;NFE2;TCF7L2;ZNF263;JUN;SMAD4;TFAP2C;SMAD3;FOXF2;NFYA;STAT1;NFYB;ESRRB;STAT3;NR2F1;NR1H3;POU2F2;USF2;ESR2;FLI1;PBX1;USF1;BATF;LHX3;BCL6;SP1;MAFF;BHLHE40;MAFK;TCF3;NFE2L2;FOXA2	GO_Molecular_Function_2018	90
nuclear chromosome part (GO:0044454)	1.26892168554086e-31	1.41484767937806e-29	12.4362244897959	SPI1;MAX;SRF;RELA;YY1;RXRA;MYC;E2F1;E2F4;JUNB;TP63;GABPA;MEF2A;SMAD2;FOXD3;TCF7L2;MEF2C;JUN;SMAD4;SMAD3;JUND;TBP;STAT1;FOXH1;TCF12;STAT3;NR1H3;PAX6;KLF4;ESR1;RUNX2;USF1;KLF1;SP1;TAL1;IRF1;MYOD1;TCF3;TP53	GO_Cellular_Component_2018	39
Integrated Breast Cancer Pathway WP1984	1.27878889400535e-12	4.64298736900402e-11	12.4172185430464	SMAD2;SMAD4;JUN;MAX;STAT1;BACH1;ESR1;FOXO1;NFKB1;FOSL1;AR;SP1;MYC;E2F1;TP53	WikiPathways_2019_Human	15
PPARA activates gene expression Homo sapiens R-HSA-1989781	1.7507401235953e-09	3.82661769871544e-07	12.1681415929204	ESRRA;SREBF1;RXRA;NFYA;SP1;NFYB;RORA;PPARG;NRF1;TEAD1;SREBF2	Reactome_2016	11
positive regulation of transcription, DNA-templated (GO:0045893)	4.55325409567952e-95	7.74508521675086e-92	11.9419642857143	FOXA1;SPI1;FOXI1;RORA;NR3C1;ETS1;ELK1;DUX4;SOX2;ELK4;MYC;MYB;SOX9;JUNB;TP63;MEF2A;MEF2C;FOXH1;EBF1;HNF1B;HNF1A;RUNX2;RUNX1;DDIT3;RFX5;ERG;MZF1;TP53;GATA4;GATA2;GATA1;FOXO1;NHLH1;SMAD2;TFAP2A;ESRRA;ZNF143;EGR1;STAT5B;NFE2;JUN;EGR2;SMAD4;TFAP2C;SMAD3;JUND;FOXF2;ESRRB;ESR1;ESR2;FLI1;NFKB1;FOSL2;FOSL1;LHX3;SP1;MAFF;REL;TCF3;NFE2L2;HNF4G;CTCF;MECOM;HNF4A;TEAD1;GABPA;MYOG;FOXD3;SREBF1;TCF12;PAX6;FOS;POU5F1;SREBF2;ELF1;NR5A2;TAL1;IRF1;MYOD1;HAND1;PPARG;CEBPA;CEBPB;HLF;PLAG1;SRF;CRX;NR2C2;RELA;RXRA;HSF1;E2F1;E2F3;STAT6;E2F4;TCF7L2;NFYA;STAT1;STAT3;NR1H3;KLF4;USF2;USF1;KLF1;REST;KLF5;FOXA2	GO_Biological_Process_2018	107
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Homo sapiens R-HSA-400206	2.31897509898003e-09	4.4350398767993e-07	11.8534482758621	ESRRA;SREBF1;RXRA;NFYA;SP1;NFYB;RORA;PPARG;NRF1;TEAD1;SREBF2	Reactome_2016	11
Osteoclast differentiation	4.4124632665155e-10	9.70741918633409e-09	11.8110236220472	FOSL1;JUN;SPI1;JUND;STAT1;STAT2;PPARG;FOS;JUNB;NFKB1;RELA;FOSL2	KEGG_2019_Human	12
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway WP2380	1.43297473249666e-10	2.70545629495369e-09	11.2847222222222	MEF2A;STAT5A;STAT5B;EGR1;MEF2C;EGR2;JUN;STAT1;STAT3;FOS;ELK1;NFKB1;RELA	WikiPathways_2019_Human	13
regulation of transcription from RNA polymerase II promoter (GO:0006357)	3.21669243311523e-122	1.6414781486187e-118	11.1637347767253	FOXA1;SPI1;GFI1;FOXI1;RORA;PRDM1;NR3C1;ETS1;ELK1;BACH1;DUX4;SOX2;FOXQ1;YY1;ELK4;MYC;MYB;SOX9;JUNB;TP63;MEF2A;MEF2C;FOXH1;RFX2;EBF1;HNF1B;RFX1;HNF1A;RUNX2;THAP1;FOXP1;RUNX1;DDIT3;RFX5;ERG;MZF1;TP53;MAX;GATA4;GATA2;GATA1;FOXO1;NHLH1;SMAD2;TFAP2A;STAT5A;ESRRA;ZNF143;EGR1;STAT5B;NFE2;ZNF263;JUN;EGR2;SMAD4;TFAP2C;SMAD3;JUND;FOXF2;ESRRB;NR2F1;ESR1;ESR2;FLI1;NFKB1;FOSL2;FOSL1;LHX3;SP2;BCL6;SP1;MAFF;BHLHE40;REL;MAFK;TCF3;NFE2L2;HNF4G;CTCF;MECOM;HNF4A;TEAD1;GABPA;MYOG;FOXD3;SREBF1;TCF12;EN1;PAX6;FOS;POU5F1;SREBF2;ELF1;ZEB1;NR5A2;TAL1;IRF1;MYOD1;ELF5;HAND1;PPARG;CEBPA;CEBPB;HLF;PLAG1;SRF;CRX;NR2C2;RELA;RXRA;NFIL3;HSF1;E2F1;E2F3;STAT6;E2F4;E2F6;TCF7L2;CDX2;STAT1;STAT2;STAT3;NR1H3;KLF4;USF2;USF1;BATF;GFI1B;REST;KLF5;INSM1;FOXA2	GO_Biological_Process_2018	132
negative regulation of cell differentiation (GO:0045596)	2.39231486891357e-10	4.88319311042638e-08	10.8333333333333	FOXA1;SMAD3;ESRRB;NR1H3;RORA;GATA2;FOXO1;HOXA9;MEIS1;E2F1;PPARG;SOX9;FOXA2	GO_Biological_Process_2018	13
EGF/EGFR Signaling Pathway WP437	4.92502372729087e-11	1.05664145421877e-09	10.8024691358025	MEF2A;STAT5A;STAT5B;MEF2C;JUN;JUND;STAT1;STAT3;FOS;ELK1;FOXO1;ELK4;SP1;E2F1	WikiPathways_2019_Human	14
negative regulation of transcription, DNA-templated (GO:0045892)	2.0498559874956e-54	1.74340251736501e-51	10.7626076260763	SPI1;GFI1;PRDM1;CTCF;NR3C1;BACH1;SOX2;YY1;ELK4;MECOM;MYC;MYB;SOX9;JUNB;TP63;MEF2A;FOXD3;MEF2C;EN1;ZBTB33;RUNX2;POU5F1;SREBF2;THAP1;FOXP1;ZEB1;DDIT3;IRF1;HAND1;PPARG;MZF1;TP53;CEBPA;CEBPB;MAX;GATA1;FOXO1;RELA;RXRA;NFIL3;HSF1;E2F1;E2F6;SMAD2;TFAP2A;TCF7L2;ZNF263;JUN;SMAD4;TFAP2C;SMAD3;JUND;CDX2;STAT1;STAT3;NR2F1;NR1H3;KLF4;ESR1;ESR2;NFKB1;GFI1B;REST;SP2;BCL6;BHLHE40;REL;MAFK;TCF3;INSM1	GO_Biological_Process_2018	70
protein heterodimerization activity (GO:0046982)	2.42327840244512e-16	1.26781520055197e-14	10.377358490566	MEF2A;MYOG;MEF2C;JUN;CEBPB;TCF12;FOS;NR2C2;USF2;NFKB1;RELA;USF1;RXRA;DDIT3;MYOD1;BHLHE40;HSF1;PPARG;TCF3;TP53;TEAD1;GABPA	GO_Molecular_Function_2018	22
transcription coactivator activity (GO:0003713)	1.10703496772509e-17	6.706301304482e-16	10.3092783505155	MEF2A;TFAP2A;NFE2;CEBPA;JUN;JUND;MAX;ESRRB;NR2F1;NR1H3;RORA;GATA4;NR2C2;ZFX;ESR2;YY1;ZEB1;RXRA;HAND1;PPARG;SOX9;TCF3;JUNB;GABPA	GO_Molecular_Function_2018	24
response to cytokine (GO:0034097)	1.45963409089894e-08	2.19073904878155e-06	9.96376811594203	JUN;SMAD3;JUND;STAT1;SRF;FOXH1;STAT3;REL;JUNB;RELA;FOXA2	GO_Biological_Process_2018	11
positive regulation of gene expression (GO:0010628)	1.54118879269854e-44	8.73854045460071e-42	9.88975356679637	SPI1;RORA;CTCF;ETS1;ELK1;SOX2;MECOM;MYC;HNF4A;MYB;SOX9;TEAD1;TP63;GABPA;MEF2C;TBP;FOXH1;HNF1B;PAX6;HNF1A;FOS;RUNX2;RUNX1;ELF1;NR5A2;TAL1;DDIT3;IRF1;PPARG;TP53;GATA4;GATA1;FOXO1;RELA;E2F1;SMAD2;TFAP2A;EGR1;NFE2;JUN;EGR2;SMAD4;SMAD3;FOXF2;NFYA;STAT1;ESRRB;STAT3;NR1H3;KLF4;ESR1;ESR2;FLI1;NFKB1;KLF1;REST;LHX3;SP1;TCF3;NFE2L2;FOXA2	GO_Biological_Process_2018	61
response to lipid (GO:0033993)	1.69682477169301e-08	2.34024238106742e-06	9.82142857142857	FOXA1;STAT5B;JUN;JUND;RXRA;STAT3;NR1H3;PPARG;JUNB;ESR1;FOXP1	GO_Biological_Process_2018	11
Cellular senescence	6.30096980574997e-09	1.14158747068882e-07	9.375	SMAD2;SMAD3;MYC;E2F1;GATA4;E2F3;E2F4;ETS1;TP53;FOXO1;NFKB1;RELA	KEGG_2019_Human	12
CCKR signaling map ST Homo sapiens P06959	8.92440395353606e-09	1.99906648559208e-07	9.09090909090909	ELK4;MEF2C;JUN;SP1;MYC;SRF;STAT3;PPARG;FOS;NR2C2;ELK1;FOXO1	Panther_2016	12
Hepatitis C	4.88197126400922e-08	8.35359527397133e-07	8.87096774193548	RXRA;STAT1;MYC;STAT2;STAT3;E2F1;NR1H3;E2F3;TP53;NFKB1;RELA	KEGG_2019_Human	11
regulation of transcription, DNA-templated (GO:0006355)	4.97278756218934e-87	6.34403373246304e-84	8.83917396745932	FOXA1;SPI1;GFI1;FOXI1;RORA;NR3C1;ETS1;ELK1;BACH1;SOX2;FOXQ1;YY1;ELK4;MYC;MYB;SOX9;SOX6;JUNB;TP63;MEF2C;FOXH1;RFX2;HNF1B;ZBTB33;RFX1;HNF1A;RUNX2;THAP1;FOXP1;RUNX1;DDIT3;RFX5;ERG;MZF1;TP53;GATA4;GATA1;FOXO1;NHLH1;HLTF;SMAD2;TFAP2A;STAT5A;ESRRA;ZNF143;EGR1;STAT5B;NFE2;ZNF263;JUN;EGR2;SMAD4;TFAP2C;SMAD3;JUND;FOXF2;ESRRB;ESR1;ESR2;FLI1;NFKB1;FOSL2;FOSL1;LHX3;SP2;BCL6;SP1;BHLHE40;TCF3;NFE2L2;HNF4G;CTCF;MECOM;HNF4A;TEAD1;GABPA;FOXD3;SREBF1;TCF12;PAX6;FOS;POU5F1;ELF1;ZEB1;NR5A2;TAL1;IRF1;MYOD1;ELF5;HAND1;PPARG;CEBPA;CEBPB;CRX;NR2C2;RELA;NFIL3;E2F1;STAT6;TCF7L2;CDX2;NFYA;STAT1;NFYB;STAT2;STAT3;NR1H3;KLF4;USF1;BATF;KLF1;REST;FOXA2	GO_Biological_Process_2018	113
Cellular Senescence Homo sapiens R-HSA-2559583	7.21430080875093e-08	8.49067710568379e-06	8.54037267080745	JUN;CEBPB;SP1;STAT3;E2F1;E2F3;FOS;ETS1;TP53;NFKB1;RELA	Reactome_2016	11
negative regulation of nucleic acid-templated transcription (GO:1903507)	1.80873776605456e-19	6.1533258801176e-17	8.44594594594595	CEBPA;SPI1;GFI1;CTCF;FOXO1;RELA;MECOM;MYB;E2F1;SOX9;TP63;SMAD2;TFAP2A;TCF7L2;ZNF263;JUN;SMAD4;ZBTB33;KLF4;RUNX2;FOXP1;REST;ZEB1;BCL6;DDIT3;IRF1;BHLHE40;HAND1;PPARG;TP53	GO_Biological_Process_2018	30
Circadian rhythm related genes WP3594	8.69878191203079e-09	1.08048027959961e-07	8.08457711442786	EGR1;SREBF1;JUN;JUND;PAX4;CRX;NR1H3;RORA;HNF1B;NFIL3;BHLHE40;PPARG;TP53	WikiPathways_2019_Human	13
Pathways in cancer	2.63917343022452e-21	4.06432708254576e-19	8.0188679245283	CEBPA;SPI1;MAX;ETS1;ELK1;FOXO1;RELA;RXRA;MECOM;MYC;STAT4;E2F1;E2F3;STAT6;SMAD2;STAT5A;STAT5B;TCF7L2;JUN;SMAD4;SMAD3;STAT1;STAT2;STAT3;FOS;ESR1;ESR2;NFKB1;RUNX1;AR;SP1;PPARG;TP53;NFE2L2	KEGG_2019_Human	34
Kaposi sarcoma-associated herpesvirus infection	3.12022085004704e-07	4.36830919006586e-06	7.39247311827957	JUN;STAT1;MYC;STAT2;STAT3;E2F1;E2F3;FOS;TP53;NFKB1;RELA	KEGG_2019_Human	11
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	9.6132756422923e-18	3.0660341001636e-15	7.32421875	CEBPA;SPI1;GFI1;CTCF;FOXO1;RELA;MECOM;MYB;E2F1;SOX9;TP63;SMAD2;TFAP2A;TCF7L2;ZNF263;JUN;SMAD4;ZBTB33;KLF4;RUNX2;FOXP1;REST;ZEB1;BCL6;DDIT3;IRF1;BHLHE40;HAND1;PPARG;TP53	GO_Biological_Process_2018	30
regulation of nucleic acid-templated transcription (GO:1903506)	2.0067284583244e-20	7.87718101756107e-18	7.20757825370675	CEBPB;CRX;RORA;GATA4;NR3C1;NR2C2;BACH1;RELA;SOX2;NFIL3;MYB;HLTF;E2F1;SOX6;ESRRA;TCF7L2;MEF2C;ZNF263;NFYA;NFYB;ESRRB;STAT3;ESR1;ESR2;POU5F1;THAP1;KLF1;REST;NR5A2;SP1;DDIT3;BHLHE40;TCF3;MZF1;TP53	GO_Biological_Process_2018	35
regulation of cellular macromolecule biosynthetic process (GO:2000112)	7.46567794345967e-21	3.17477954545622e-18	7.13153724247227	CEBPB;CRX;RORA;GATA4;NR3C1;NR2C2;BACH1;GATA1;RELA;SOX2;NFIL3;MYB;HLTF;E2F1;SOX6;ESRRA;TCF7L2;MEF2C;ZNF263;NFYA;NFYB;ESRRB;STAT3;ESR1;ESR2;POU5F1;THAP1;KLF1;REST;NR5A2;SP1;DDIT3;BHLHE40;TCF3;MZF1;TP53	GO_Biological_Process_2018	36
cellular response to cytokine stimulus (GO:0071345)	3.51155775485873e-15	8.95973961152205e-13	7.12719298245614	CEBPA;RORA;FOXO1;RELA;SOX2;MYC;STAT4;STAT6;SOX9;JUNB;STAT5A;EGR1;STAT5B;SMAD3;STAT1;STAT2;FOXH1;STAT3;FOS;NFKB1;BATF;ZEB1;BCL6;IRF1;TP53;NFE2L2	GO_Biological_Process_2018	26
negative regulation of gene expression (GO:0010629)	3.57641022782262e-20	1.30360152804134e-17	7.07928802588997	CEBPA;SPI1;GFI1;CTCF;FOXO1;RELA;YY1;MECOM;MYB;E2F1;SOX9;TP63;SMAD2;TFAP2A;TCF7L2;MEF2C;ZNF263;JUN;SMAD4;ZBTB33;KLF4;ESR1;RUNX2;NFKB1;FOXP1;REST;ZEB1;BCL6;DDIT3;IRF1;BHLHE40;HAND1;REL;PPARG;TP53	GO_Biological_Process_2018	35
negative regulation of cell proliferation (GO:0008285)	1.27482768327371e-11	2.71060236156073e-09	6.8870523415978	TFAP2A;MYOG;CEBPA;CTCF;GATA2;KLF4;ETS1;DUX4;SOX2;REST;MYC;HNF4A;IRF1;BHLHE40;E2F1;PPARG;E2F3;SOX9;INSM1;TP53	GO_Biological_Process_2018	20
VEGFA-VEGFR2 Signaling Pathway WP3888	5.85390257532021e-08	6.00661307728509e-07	6.88559322033898	EGR1;MEF2C;JUN;STAT1;SRF;STAT3;ETS1;ELK1;FOXO1;NFKB1;RELA;STAT6;ERG	WikiPathways_2019_Human	13
Viral carcinogenesis	6.76147697374065e-07	8.33013963164848e-06	6.8407960199005	STAT5A;STAT5B;JUN;EGR2;TBP;SRF;STAT3;REL;TP53;NFKB1;RELA	KEGG_2019_Human	11
positive regulation of macromolecule metabolic process (GO:0010604)	6.42677191208854e-09	1.13089024370303e-06	6.79347826086956	TFAP2A;EGR1;MEF2C;SMAD3;STAT3;PAX6;CTCF;KLF4;ETS1;SP1;MYC;E2F1;TP53;GABPA;NFE2L2	GO_Biological_Process_2018	15
Developmental Biology Homo sapiens R-HSA-1266738	2.81555258773992e-23	4.30779545924208e-20	6.6793893129771	CEBPA;CEBPB;HNF4G;CTCF;FOXO1;RELA;SOX2;YY1;RXRA;HNF4A;MEF2A;SMAD2;MYOG;FOXD3;SREBF1;MEF2C;JUN;EGR2;SMAD4;SMAD3;CDX2;FOXH1;TCF12;STAT3;EBF1;PAX4;HNF1B;PAX6;HNF1A;KLF4;NFKB1;PBX1;POU5F1;SREBF2;MEIS1;NR5A2;KLF5;MYOD1;PPARG;TCF3;INSM1;FOXA2	Reactome_2016	42
Nuclear Receptors Meta-Pathway WP2882	8.03600881506407e-10	1.30792971058974e-08	6.66144200626959	EGR1;SREBF1;JUN;JUND;STAT3;NR1H3;NR3C1;ESR1;FOXO1;POU5F1;RXRA;SP1;MYC;MAFF;BHLHE40;JUNB;NFE2L2	WikiPathways_2019_Human	17
MAPK Signaling Pathway WP382	9.50567444072707e-08	9.34724653338162e-07	6.60569105691057	MEF2C;JUN;JUND;MAX;SRF;FOS;ELK1;NFKB1;RELA;ELK4;MYC;DDIT3;TP53	WikiPathways_2019_Human	13
Fatty acid, triacylglycerol, and ketone body metabolism Homo sapiens R-HSA-535734	1.43694917888941e-06	0.000115712223352673	6.33640552995392	ESRRA;SREBF1;RXRA;NFYA;SP1;NFYB;RORA;PPARG;NRF1;TEAD1;SREBF2	Reactome_2016	11
regulation of gene expression (GO:0010468)	8.00908871425369e-27	3.71548906443969e-24	6.14754098360656	RORA;CTCF;NR3C1;ETS1;BACH1;SOX2;YY1;MYC;MYB;SOX6;GABPA;MEF2C;PAX6;POU5F1;THAP1;NR5A2;DDIT3;MYOD1;MZF1;TP53;CEBPB;CRX;GATA4;NR2C2;RELA;NFIL3;HLTF;E2F1;TFAP2A;ESRRA;EGR1;TCF7L2;ZNF263;TFAP2C;SMAD3;NFYA;NFYB;ESRRB;STAT3;KLF4;ESR1;ESR2;NFKB1;KLF1;REST;SP1;BHLHE40;REL;TCF3;INSM1;NFE2L2	GO_Biological_Process_2018	51
MAPK signaling pathway	1.13622829558373e-07	1.84188586863046e-06	5.93220338983051	MEF2C;JUN;JUND;MAX;SRF;FOS;ELK1;NFKB1;RELA;ELK4;MECOM;MYC;DDIT3;TP53	KEGG_2019_Human	14
cellular response to oxygen-containing compound (GO:1901701)	3.29350596580391e-07	3.36135218869947e-05	5.93065693430657	MYOG;EGR1;MEF2C;JUN;GFI1;NR1H3;RORA;FOS;ESR1;NFKB1;RELA;MYOD1;SOX9	GO_Biological_Process_2018	13
Generic Transcription Pathway Homo sapiens R-HSA-212436	1.29523902917603e-15	6.60571904879776e-13	5.23399014778325	HNF4G;RORA;GATA4;PRDM1;NR3C1;NR2C2;RXRA;MYC;HNF4A;E2F1;E2F4;JUNB;TEAD1;TP63;SMAD2;ESRRA;ZNF263;JUN;SMAD4;SMAD3;TBP;ESRRB;NR2F1;NR1H3;FOS;ESR1;RUNX2;ESR2;AR;NR5A2;BCL6;SP1;PPARG;TP53	Reactome_2016	34
ubiquitin-like protein ligase binding (GO:0044389)	2.81540068326976e-05	0.000771553853915119	4.62962962962963	SMAD2;JUN;EGR2;SMAD3;STAT1;STAT2;HLTF;TP53;FOXO1;POU5F1;RELA	GO_Molecular_Function_2018	11
cytokine-mediated signaling pathway (GO:0019221)	1.35971149034377e-09	2.66869528277855e-07	4.54186413902054	STAT5A;EGR1;STAT5B;CEBPA;SMAD4;STAT1;STAT2;STAT3;RORA;FOS;FOXO1;NFKB1;RELA;BATF;SOX2;ZEB1;BCL6;MYC;IRF1;STAT4;STAT6;JUNB;TP53	GO_Biological_Process_2018	23
positive regulation of apoptotic process (GO:0043065)	3.80836457526027e-05	0.00211240048125578	4.47882736156352	FOXA1;TFAP2A;JUN;REST;BCL6;MYC;DDIT3;E2F1;TP53;TP63;FOXO1	GO_Biological_Process_2018	11
negative regulation of cellular process (GO:0048523)	2.93157160101585e-07	3.11662705832997e-05	4.21348314606742	TFAP2A;MYOG;CEBPA;SMAD4;SMAD3;CTCF;KLF4;ETS1;DUX4;ESR2;REST;BCL6;MYC;HNF4A;IRF1;BHLHE40;INSM1;TP53	GO_Biological_Process_2018	18
protein homodimerization activity (GO:0042803)	1.70402087663141e-08	5.7686118500081e-07	4.14156626506024	TFAP2A;CEBPA;JUN;SMAD4;CEBPB;SMAD3;MAX;STAT1;SRF;TCF12;STAT3;USF2;RELA;USF1;THAP1;SP1;DDIT3;HNF4A;BHLHE40;HAND1;TCF3;MZF1	GO_Molecular_Function_2018	22
Cellular responses to stress Homo sapiens R-HSA-2262752	4.11365143639727e-05	0.00112390833887283	4.08719346049046	JUN;CEBPB;SP1;HSF1;STAT3;E2F1;E2F3;FOS;ETS1;TP53;NFKB1;RELA	Reactome_2016	12
regulation of cell proliferation (GO:0042127)	5.37884490085402e-09	9.80294483180646e-07	4.05405405405405	TFAP2A;MYOG;CEBPA;TCF7L2;JUN;TFAP2C;JUND;CTCF;KLF4;ETS1;DUX4;RELA;FOSL1;REST;BCL6;MYC;HNF4A;IRF1;BHLHE40;HSF1;SOX9;INSM1;JUNB;TP53	GO_Biological_Process_2018	24
regulation of apoptotic process (GO:0042981)	9.52715850066002e-05	0.00426465700253229	2.76073619631902	FOXA1;TFAP2A;MEF2C;JUN;STAT1;STAT3;GATA1;FOXO1;NFKB1;RELA;SOX2;REST;BCL6;MYC;E2F1;SOX9;TP53;TP63	GO_Biological_Process_2018	18
Gene Expression Homo sapiens R-HSA-74160	1.70020163955749e-08	2.36482591683905e-06	2.75904353157572	HNF4G;RORA;GATA4;PRDM1;NR3C1;NR2C2;RXRA;MYC;HNF4A;E2F1;E2F4;JUNB;TEAD1;TP63;SMAD2;ESRRA;ZNF143;ZNF263;JUN;SMAD4;SMAD3;TBP;ESRRB;NR2F1;NR1H3;FOS;POU2F2;ESR1;RUNX2;ESR2;AR;NR5A2;BCL6;SP1;PPARG;TP53	Reactome_2016	36
