Gene_Set	Direction	Enrichment	n	b	N	B	p.value	Driver_Genes	adj.p.val
HALLMARK_ANGIOGENESIS	DOWN	7.22692827351231	587	8	15378	8	0.00013203792358063	VCAN,COL5A2,COL3A1,VAV2,CCND2,VTN,POSTN,STC1,FGFR1,FSTL1,TNFRSF21,SPP1,THBD,ITGAV,SLCO2A1,APOH,LRPAP1,MSX1,LUM,KCNJ8,JAG1,NRP1,VEGFA,PGLYRP1,LPL,PTK2,PDGFA,APP,JAG2	0.00101567633523562
HALLMARK_KRAS_SIGNALING_DN	UP	1.34061101532381	7554	81	15378	81	0.00248225893532872	RSAD2,ODZ2,ITIH3,PLAG1,RYR2,MX1,SLC6A3,CAMK1D,NPHS1,ZFP112,HTR1B,IDUA,TNNI3,SLC29A3,FGFR3,MLL2,FAM46C,PTPRJ,MAST3,PDK2,NOS1,CELSR2,PDE6B,BMPR1B,SLC25A23,MFSD6,EFHD1,DLK2,PCDHB1,SYNPO,ADCK3,FGGY,RGS11,PARK2,CPA2,FGF22,KCNQ2,AKR1B10,EDN1,STAG3,HTR1D,KCNN1,MTHFR,FGF16,DCC,SNCB,SGK1,KLK8,ZBTB16,IRS4,SLC5A5,SKIL,SOX10,SLC16A7,BRDT,NUDT11,SIDT1,FAM164C,CPEB3,CNTFR,KCND1,EGF,SLC30A3,NR4A2,SLC38A3,BARD1,RYR1,CD80,PTGFR,ENTPD7,COL2A1,TCF7L1,SSTR4,MAGIX,WNT16,NR6A1,NRIP2,RIBC2,KRT1,P2RX6,YBX2,SNN,PRODH,GPRC5C,GPR19,ALOX12B,GRID2,ADRA2C,GPR3,CDKAL1,CLSTN3,BTG2,DTNB,ARHGDIG,KCNMB1,SPHK2,COPZ2,KLHDC8A,ITGB1BP2,THNSL2,THRB,CHST2,ABCG4,MSH5,ASB7,ARPP21,IGFBP2,CCDC106,GDNF,CCDC132,H2AFY2,TEX15,GAMT,EDAR,SEPP1,TGFB2,SMPX,GTF3C5,EPHA5,YPEL1,LFNG,MYH7,CYP39A1	0.0174471749610427
HALLMARK_ESTROGEN_RESPONSE_EARLY	UP	1.8080703569581	1933	40	15378	40	0.00261707624415641	CYP26B1,TGM2,CXCL12,ENDOD1,MREG,KRT18,KRT8,AFF1,SLC2A1,TIAM1,MLPH,AQP3,DHRS3,IGF1R,RAPGEFL1,PMAIP1,ADCY9,OLFML3,FLNB,AR,SCARB1,PODXL,SCNN1A,B4GALT1,SYNGR1,FHL2,SLC27A2,PGR,MYBL1,IL6ST,TPBG,MYC,NCOR2,PAPSS2,CELSR2,SYT12,RARA,TJP3,NAV2,GREB1,ABAT,GAB2,MAPT,ABHD2,DEPTOR,BCL11B,CISH,NRIP1,FARP1,SLC7A2,CD44,MED13L,FDFT1,SEC14L2,SEMA3B,PDLIM3,SFN,TPD52L1,KLF10,FAM134B,FKBP5,RHOD,TTC39A,MED24,FAM102A,RPS6KA2,IL17RB,EGR3,RASGRP1,ITPK1,PTGES,DLC1,MYOF,DHCR7,ANXA9,PDZK1,P2RY2,TBC1D30,FOXC1,KAZN,SOX3,KCNK15,FASN,KLF4,ALDH3B1,AKAP1,ABCA3,PRSS23,LAD1,CELSR1,CCND1,FAM63A,RET,ADD3,BAG1,WFS1,RHOBTB3,SLC22A5,CANT1,ELF1,MYBBP1A,ADCY1,ASB13,HR,RAB31,KCNK5,FRK,ISG20L2,ABLIM1,NADSYN1,JAK2,PLA2G16,RRP12,THSD4,BLVRB,TIPARP,NBL1,MPPED2,WWC1,ARL3,NPY1R,XBP1,ELOVL5,OLFM1,HSPB8,TSKU,CBFA2T3,PPIF,LRIG1,INPP5F,GLA,MYB,KDM4B,TGIF2,SLC19A2,RBBP8,PEX11A,SLC39A6,TOB1,FOS,AREG,SLC26A2,DYNLT3,SLC9A3R1,SNX24,AMFR,SH3BP5,CHPT1,GFRA1,NXT1,SULT2B1,ELOVL2,BCL2,SLC7A5,UGCG,SIAH2,FKBP4,MUC1,SLC1A1,SLC37A1,INHBB,HES1,SLC16A1,SVIL,STC2,SLC24A3,OPN3,SLC1A4,CALB2,UNC119,SYBU,TMEM164,REEP1,GJA1,IGFBP4,TUBB2B	0.0174471749610427
HALLMARK_COAGULATION	UP	2.54415441176471	1280	18	15378	18	0.00318765365446438	VWF,C1QA,SERPING1,PECAM1,PROS1,C3,CFB,MMP11,TMPRSS6,COMP,CSRP1,THBS1,SPARC,ANXA1,PLEK,C2,CAPN5,A2M,LRP1,CTSH,CTSB,FN1,CRIP2,APOC1,CFH,ANG,USP11,MSRB2,C1S,MMP14,CLU,TIMP3,LAMP2,ITGB3,MMP9,ITGA2,KLK8,CAPN2,P2RY1,SIRT2,PREP,MMP2,SERPINE1,LGMN,FBN1,CASP9,DCT,PGCP,RAC1,PRSS23,LTA4H,PEF1,F8,KLF7,ADAM9,DUSP14,CTSO,CTSK,WDR1,ARF4,THBD,PDGFB,FURIN,GNB2,FYN,MASP2,S100A1,F3,S100A13,CD9,DPP4,ISCU,PLAU,GNG12,HTRA1,HMGCS2,MAFF,SH2B2,RABIF,BMP1,RAPGEF3,MMP15,GDA,GSN,PLAT	0.0193338391851545
HALLMARK_GLYCOLYSIS	DOWN	1.79146207209883	1929	40	15378	40	0.00328675266147627	VCAN,CTH,GPC4,NASP,PGLS,SAP30,SDC1,IDH1,HS2ST1,HAX1,MET,COPB2,STC1,CXCR4,BPNT1,STMN1,FAM162A,SLC25A10,HSPA5,STC2,TALDO1,PPIA,DCN,GFPT1,B4GALT4,VLDLR,EGFR,POLR3K,ERO1L,GPC3,MDH1,GLCE,UGP2,RPE,FKBP4,B3GALT6,GALK1,SLC37A4,COL5A1,PGAM1,PPFIA4,ARPP19,XYLT2,DLD,SDHC,PYGB,CHST12,PGK1,AGRN,LHPP,PLOD1,AURKA,DPYSL4,HS6ST2,ENO1,PFKFB1,NDST3,GALK2,PLOD2,SPAG4,RBCK1,DDIT4,CHST2,KIF2A,ANGPTL4,MIF,SDC3,GPC1,RARS,EXT1,GYS1,PAM,IGFBP3,FUT8,TGFBI,LDHA,PPP2CB,GALE,MDH2,B3GAT3,SOX9,PMM2,SDC2,PSMC4,MPI,KDELR3,EXT2,GMPPB,PDK3,COG2,HOMER1,CITED2,DSC2,NANP,PAXIP1,GAL3ST1,CHPF2,CENPA,ME2,CASP6,TSTA3,ALDH7A1,NT5E,PGM2,B3GAT1,MXI1,ECD,PYGL,SLC25A13,HMMR,P4HA1,GNPDA1,CLN6,CHPF,GOT2,AK4,B4GALT2,TGFA,ENO2,CDK1,ALDOA,AK3,NDUFV3,KIF20A,LHX9,NSDHL,ADORA2B,ABCB6,AGL,GNE,B4GALT7,GMPPA,ALG1,SLC35A3,HDLBP,PGAM2,ALDOB,MED24,GUSB,B3GNT3,PKM2,VEGFA,IER3,IL13RA1,ISG20,SLC16A3,PRPS1,PKP2,CD44,TPI1,SOD1,HK2,EGLN3,ANG,RRAGD,ME1,IRS2,PHKA2,QSOX1,ANKZF1,CHST1,EFNA3,CACNA1H,TPST1,GCLC,ARTN,TPBG,GOT1,B4GALT1,CAPN5,NOL3,SRD5A3,GLRX,IDUA,PFKP,MERTK,ALDH9A1,P4HA2	0.0193338391851545
HALLMARK_UV_RESPONSE_DN	DOWN	4.88986048730077	181	8	15378	8	0.00449138551294137	RND3,COL11A1,COL5A2,PRKAR2B,COL3A1,VAV2,CDON,BDNF,GJA1,GRK5,MET,HAS2,RGS4,BCKDHB,DDAH1,CDKN1B,NFIB,KIT,VLDLR,MGLL,LTBP1,TFPI,MIOS,LAMC1,PLCB4,LPHN2,RASA2,ACVR2A,MTA1,F3,PPAP2B,SNAI2,IRS1,COL1A2,SLC7A1,ANXA2,ATP2B4,CAV1,NOTCH2,FYN,PIK3R3,PTPN21,PIAS3,SCHIP1,MMP16,MAP2K5,LPAR1,MGMT,ATP2C1,PDLIM5,SRI,MRPS31,AKT3,PAPD7,TJP1,DUSP1,SDC2,FZD2,CYR61,AGGF1,DAB2,INPP4B,FAM179B,ATRX,ATRN,CITED2,DLG1,EFEMP1,ADD3,MAGI2,DBP,BMPR1A,NIPBL,PTPRM,ANXA4,PDGFRB,IGFBP5,COL1A1,PTGFR,WDR37,PTEN,ARHGEF9,SERPINE1,GCNT1,AMPH,ATP5S,ADORA2B,DLC1,ICA1,CDK13,TGFBR3,RXRA,ZMIZ1,NRP1,NR1D2,MAPK14,ITGB3,PRDM2,PHF3,NR3C1,PIK3CD,PEX14,ERBB2,ABCC1,CDC42BPA,SFMBT1,PPARG,APBB2,FBLN5,CELF2,CACNA1A,KALRN,NFKB1,YTHDC1,LDLR,SCAF8,SCN8A,DYRK1A,NEK7,SPOP,ID1,SMAD3,MYC,CAP2,FHL2,KCNMA1,ATXN1,INSIG1,PMP22,SMAD7,PRKCE,ATP2B1,IGF1R,SYNJ2,RUNX1,TGFBR2,SIPA1L1,RBPMS,SYNE1	0.0229409956467787
HALLMARK_E2F_TARGETS	DOWN	3.03848705101969	383	14	15378	14	0.00466231767903613	LMNB1,NME1,HN1,TFRC,SPC25,EZH2,TOP2A,MKI67,NASP,E2F8,H2AFZ,KPNA2,HUS1,TUBG1,CDCA8,STMN1,ZW10,CDCA3,UBE2S,RANBP1,RQCD1,KIF2C,CDKN1B,CHEK1,EIF2S1,TCF19,POLA2,POLE4,PLK1,CDC20,MXD3,BRCA1,PPP1R8,SMC4,EXOSC8,PSMC3IP,RACGAP1,KIF22,ORC2,SYNCRIP,H2AFX,MYBL2,RAD1,BRMS1L,STAG1,SLBP,DSCC1,AURKA,RBBP7,ORC6,SMC6,PA2G4,DCK,MLH1,CTPS,IPO7,LYAR,XPO1,MCM7,PLK4,PDS5B,CDK4,GINS3,ATAD2,PHF5A,DUT,MCM5,SRSF1,PRIM2,MCM2,SRSF2,GSPT1,CENPE,NOP56,CBX5,GINS1,AK2,RAN,POP7,HMGA1,PPM1D,NUP153,NCAPD2,ASF1A,ING3,CENPM,CHEK2,CSE1L,RAD51AP1,MAD2L1,NUP205,RAD51C,SUV39H1,RFC3,NAA38,PAICS,GINS4,ESPL1,MTHFD2,NUDT21,MSH2,PAN2,ANP32E,HMGB3,UBR7,HMMR,CKS1B,CTCF,TBRG4,WDR90,TACC3,TRA2B,DCLRE1B,SNRPB,USP1,UBE2T,DONSON,NBN,PRDX4,CDKN1A,DCTPP1,PSIP1,RFC2,BARD1,XRCC6,CDK1,SHMT1,SMC1A,PRKDC,LUC7L3,SSRP1,NUP107,RPA3,MCM3,TIPIN,CDC25A,NAP1L1,EED,CDKN2C,MCM4,HMGB2,DNMT1,RNASEH2A,SPAG5,TMPO,RRM2,SPC24,POLD3,CCNE1,UNG,RAD21,CCNB2,POLE,PNN,PRPS1,WEE1,TRIP13,BRCA2,SMC3,CDC25B,POLD2,PCNA,ASF1B,RAD50,MCM6,LIG1,HELLS,CIT,RFC1,MRE11A,CKS2,LBR,MMS22L,RPA1,MYC,HNRNPD,DLGAP5,ILF3,RPA2,POLD1,PMS2,NOLC1,TIMELESS,BUB1B,PTTG1	0.0229409956467787
HALLMARK_XENOBIOTIC_METABOLISM	UP	2.22460249572306	1046	23	15378	23	0.00469211326980412	CYP2E1,XDH,IL1R1,SLC46A3,PROS1,CFB,FETUB,EPHX1,GCNT2,SLC6A6,ALDH9A1,CD36,CYP1A2,RBP4,CYFIP2,GAD1,AOX1,IRF8,BCAT1,ALAS1,DDC,SPINT2,NPC1,ALDH2,GABARAPL1,PDK4,GCLC,PAPSS2,FAH,TPST1,TNFRSF1A,MPP2,NDRG2,JUP,RETSAT,NMT1,DHRS7,PINK1,PSMB10,PTGR1,DHPS,ADH5,HMOX1,TMBIM6,UPP1,ANGPTL3,CYP27A1,BCAR1,SLC35B1,ESR1,ETS2,SLC12A4,UPB1,HES6,ACP2,SLC1A5,GSTA3,ABCC3,ASL,ACOX1,ENTPD5,PEMT,MTHFD1,LPIN2,CSAD,ARG2,GCH1,GSTM4,PTGES,HACL1,MAOA,AHCY,ACOX3,GSR,ACO2,PPARD,SERPINE1,ENPEP,MARCH6,RAP1GAP,ATP2A2,TMEM97,SLC35D1,HSD11B1,EPHA2,FAS,ABCC2,COMT,ABCD2,SLC6A12,CASP6,PGRMC1,PMM1,SAR1B,ATOH8,CNDP2,DCXR,PYCR1,SMOX,CCL25,BLVRB,CBR1,NFS1,ELOVL5,POR,DHRS1,GART,DDAH2,KARS,PDLIM5,CROT,ETFDH,CDA,MCCC2,TMEM176B,ABHD6,ID2,AQP9,SERTAD1,GSTO1,LONP1,NINJ1,ARPP19,SSR3,TTPA,UGDH,LCAT,SHMT2,AP4B1,TGFB2,CYP2S1,DAK,DDT,PTGES3,FBLN1,CAT,IGF1,ACP1,PTS,PGD,GSS,BPHL,NQO1,ECH1,FMO1,IDH1,VTN,GSTT2,CDO1,IGFBP4,APOE,PTGDS	0.0229409956467787
HALLMARK_MTORC1_SIGNALING	DOWN	1.34040534889177	5767	94	15378	94	0.00481760908582352	SERPINH1,CTH,MTHFD2L,TFRC,RPN1,FADS2,TUBG1,MLLT11,TES,IDH1,STC1,CXCR4,PSMD12,PPA1,SLC1A4,PSAT1,PSMA3,PSMA4,HSPA5,PPIA,TCEA1,PLK1,ARPC5L,VLDLR,ERO1L,GGA2,CCT6A,SEC11A,SLC2A3,CALR,SLC37A4,EEF1E1,ASNS,HSP90B1,EPRS,SLC7A5,SHMT2,HSPD1,RIT1,ETF1,CD9,IFRD1,HMBS,HSPA4,UFM1,ACTR3,PRDX1,SERP1,NFIL3,PHGDH,PGK1,PSMD13,BUB1,AURKA,FADS1,SLC9A3R1,PSPH,UBE2D3,PIK3R3,ENO1,PSMG1,WARS,CCNG1,PLOD2,DDIT4,PPP1R15A,PITPNB,HMGCS1,COPS5,GLA,TXNRD1,NFKBIB,ATP5G1,MCM2,CACYBP,IMMT,MAP2K3,PSMB5,RDH11,ELOVL5,ATP6V1D,XBP1,LDHA,TOMM40,SLC7A11,USO1,HSPE1,PNP,EIF2S2,PGM1,YKT6,PSMD14,BTG2,PSMC4,PNO1,TBK1,NUFIP1,FKBP2,NAMPT,GBE1,GTF2H1,CANX,CYB5B,M6PR,NUP205,CCNF,MTHFD2,ADD3,LTA4H,TM7SF2,ACACA,CORO1A,EDEM1,DHCR24,IDI1,ACSL3,IGFBP5,P4HA1,STARD4,LGMN,STIP1,TMEM97,ATP2A2,CDKN1A,PSME3,AK4,ELOVL6,DAPP1,HSPA9,ABCF2,IFI30,GSR,ALDOA,DHFR,NFYC,DHCR7,GAPDH,CDC25A,DDIT3,POLR3G,PDK1,FDXR,MCM4,SLA,PDAP1,TRIB3,FGL2,FAM129A,RRM2,EBP,PSMC2,SLC1A5,UNG,UCHL5,GSK3B,CTSC,TUBA4A,CFP,NUPR1,SRD5A1,TPI1,SQLE,HK2,EGLN3,NMT1,ME1,PFKL,ACLY,LDLR,RPA1,SDF2L1,RRP9,GCLC,SSR1,GOT1,QDPR,SQSTM1,INSIG1,ADIPOR2,GLRX,SORD,BCAT1,SKAP2,SYTL2,SLC6A6,SLC2A1,ITGB2	0.0229409956467787
HALLMARK_MYOGENESIS	UP	1.79386728208232	1888	37	15378	37	0.00519935512201852	MYH11,TNNT1,DES,CRYAB,MYH9,BDKRB2,ITGB5,CTF1,CD36,MYLK,SMTN,SYNGR2,APP,ACTN3,SPARC,ADCY9,TPM2,COL6A3,LSP1,TAGLN,MEF2D,DMPK,TNNT2,MYOM1,DMD,GPX3,SPEG,HBEGF,PTP4A3,LAMA2,AEBP1,SORBS1,NOS1,COL6A2,CACNA1H,NAV2,SSPN,COX6A2,SORBS3,PSEN2,LPIN1,PYGM,MAPK12,KCNH2,MEF2C,CLU,DTNA,KCNH1,PTGIS,FLII,PDE4DIP,ITGB4,SLC6A8,TPD52L1,TCAP,FGF2,LDB3,MEF2A,HRC,PGAM2,TSC2,ACSL1,EFS,PRNP,FXYD1,CAMK2B,ACTN2,CASQ2,CRAT,SIRT2,RB1,AGL,SPHK1,COL4A2,GJA5,ENO3,PFKM,TNNI1,HDAC5,AKT2,EPHB3,CDKN1A,AK1,GAA,FDPS,APOD,RYR1,COX7A1,MYOM2,VIPR1,MYL1,COL1A1,FHL1,BIN1,MYL6B,TNNI2,HSPB2,BAG1,CHRNB1,ATP6AP1,SOD3,MRAS,MYO1C,ABLIM1,PICK1,IGFBP7,PVALB,SGCD,PLXNB2,LARGE,IGFBP3,APLNR,HSPB8,TGFB1,NCAM1,OCEL1,MAPRE3,KIFC3,MYH3,NOTCH1,SCHIP1,CKB,GADD45B,FOXO4,AGRN,FABP3,MYBPH,IFRD1,PPP1R3C,RIT1,KLF5,MYLPF,PKIA,PPFIA4,GNAO1,SH2B1,TEAD4,PDLIM7,ACHE,ITGB1,MYL4,WWTR1,IGF1,ST5,EIF4A2,GABARAPL2,TPM3,ERBB3,SVIL,SH3BGR,STC2,SGCG,DAPK2,ACTA1,MYH8,ITGA7,FST,MYOZ1,NQO1,REEP1,ADAM12,FKBP1B,GSN,CDH13,COL15A1,MYH7,CNN3,COL3A1	0.0236334323728115
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	DOWN	2.39432603190992	1341	38	15378	38	1.02141366258302e-05	TNC,DPYSL3,VCAN,OXTR,COL11A1,SERPINH1,COL5A2,COL3A1,IGFBP4,THBS2,BDNF,GJA1,VEGFC,ADAM12,GEM,POSTN,CALU,SDC1,PPIB,INHBA,MEST,GPX7,CDH2,RGS4,FBLN2,ANPEP,GAS1,SGCG,DCN,SFRP4,COL12A1,WNT5A,FZD8,BMP1,BASP1,CTGF,NID2,SNTB1,FBLN1,ITGB1,HTRA1,COL8A2,COL5A1,ABI3BP,LOXL1,FBN2,LAMC1,FSTL1,PRRX1,PDLIM4,TNFRSF12A,SNAI2,FAP,MAGEE1,COL1A2,CDH11,PFN2,IGFBP2,PLAUR,COL16A1,NOTCH2,PLOD1,ID2,TPM4,GADD45B,PMEPA1,SPP1,AREG,CDH6,MCM7,RHOB,PLOD2,LAMA3,PVR,MGP,TGFB1,GPC1,SERPINE2,IGFBP3,GLT25D1,TGFBI,FSTL3,COPA,NTM,GADD45A,SGCD,LEPRE1,PTHLH,CYR61,ITGAV,DAB2,ECM2,BGN,IL15,PLOD3,JUN,EDIL3,SAT1,CTHRC1,NT5E,TNFAIP3,COL4A1,FERMT2,LOX,SCG2,SLIT2,PDGFRB,COL1A1,FAS,MSX1,FBN1,LAMC2,LUM,MATN2,FOXC2,CRLF1,EMP3,ENO2,SERPINE1,FMOD,TNFRSF11B,COL7A1,MMP2,PCOLCE,VIM,COL4A2,ECM1,ITGA5,TGFBR3,THY1,SGCB,PTX3,ITGA2,FGF2,ITGB3,SLC6A8,VEGFA,LAMA1,ELN,LOXL2,TIMP3,MYL9,FLNA,LGALS1,EFEMP2,CD44,SFRP1,MMP14,APLP1,FUCA1,TPM1,SDC4,FBLN5,COL5A3,CAPG,QSOX1,CADM1,FN1,COL6A2,LRP1,CAP2,LAMA2,CALD1,PCOLCE2,TAGLN,PMP22,SLIT3,COL6A3,TPM2,GREM1,SPARC,THBS1,COMP,MYLK,ITGB5,WIPF1,VCAM1,DST,SPOCK1,CXCL12,ACTA2,TGM2	0.000117087679236189
HALLMARK_COMPLEMENT	UP	2.01696675900277	2508	50	15378	50	1.0537891131257e-05	IRF7,CTSS,F5,C1QC,C1QA,PLA2G4A,SERPING1,C3,CFB,PCLO,DGKH,LGALS3,CP,CTSD,FCER1G,ITGAM,TMPRSS6,S100A9,CD36,PIK3CG,LAP3,CSRP1,IRF1,GNGT2,RHOG,GCA,PLEK,C2,ZFPM2,SH2B3,ZFYVE20,CASP4,LCP2,TIMP2,PIM1,LRP1,PRKCD,CPM,CTSH,CTSB,LTF,FN1,SIRT6,PIK3R5,APOC1,CASP1,CFH,ME1,ANXA5,ANG,PSMB9,DOCK9,C1S,DGKG,PRSS36,MMP14,CLU,KCNIP2,CTSC,LAMP2,DOCK10,SPOCK2,HSPA1A,IRF2,KCNIP3,ACTN2,ZEB1,RASGRP1,USP8,CBLB,COL4A2,PREP,RNF4,SERPINE1,HPCAL4,CEBPB,VCPIP1,BRPF3,DUSP5,LGMN,CASP9,PGCP,PHEX,AKAP10,GNAI2,MT3,LTA4H,ADRA2B,PIK3CA,PCSK9,TNFAIP3,GRB2,PRDM4,PLSCR1,RAF1,LIPA,RCE1,JAK2,PSEN1,CD46,F8,GNAI3,PPP2CB,CALM3,ADAM9,CTSO,USP15,GPD2,USP14,CALM1,SCG3,EHD1,KIF2A,LYN,NOTCH4,CASP3,ATOX1,SRC,WAS,PPP4C,PFN1,PDGFB,PLA2G7,CDA,CASP7,CDK5R1,GNB2,FYN,DOCK4,PLAUR,FDX1,F3,S100A13,DPP4,L3MBTL4,XPNPEP1,USP16,MAFF,PRCP,LCK,RABIF,PDP1,HSPA5,CR2,DYRK2,SEPX1,MMP15,GNG2,CDH13,PLAT,CD55,GNB4	0.000117087679236189
HALLMARK_ALLOGRAFT_REJECTION	UP	3.78023598820059	904	30	15378	30	1.11552702630746e-08	IRF7,B2M,ITGB2,GBP2,CTSS,STAT1,TAP1,FYB,PTPN6,PTPRC,CD3G,TAP2,CD8A,HCLS1,TLR2,CSF1,GPR65,FGR,ELF4,FCGR2B,LY86,ICAM1,TAPBP,CD74,TLR6,IL16,SRGN,IRF8,BCAT1,IGSF6,RPS3A,C2,IFNAR2,RPL39,CCR2,LCP2,MAP4K1,IL12A,CD40,NOS2,CAPG,ITGAL,PSMB10,CCR1,ST8SIA4,IL2RA,BCL3,SOCS1,CD247,PRKCB,TLR3,STAB1,FLNA,IRF4,CFP,EIF4G3,EIF3D,TLR1,CD86,IFNGR1,IL2RG,MMP9,TRAF2,RPS19,RPS9,LIF,ABI1,THY1,EIF3J,IL27RA,ETS1,CCR5,IFNGR2,NCF4,AKT1,GCNT1,NPM1,CD28,IL18,SOCS5,CD80,EIF3A,IL12RB1,STAT4,CD47,FAS,NLRP3,CCND3,KRT1,APBB1,IKBKB,ITK,IL15,CCL19,HDAC9,ZAP70,DYRK3,JAK2,AARS,EIF5A,UBE2N,DEGS1,GLMN,CSK,MRPL3,F2R,TPD52,RARS,TGFB1,MTIF2,LYN,WAS,WARS,MAP3K7,LY75,GALNT1,RIPK2,ACVR2A,HIF1A,RPL9,TGFB2,CXCL9,ACHE,BRCA1,EGFR,LCK,NCK1,INHBB,DARS,CARTPT,INHBA,BCL10,UBE2D1,CCND2,NME1	2.23105405261492e-07
HALLMARK_G2M_CHECKPOINT	DOWN	4.0113614955438	373	18	15378	18	1.88289649084572e-05	CENPF,LMNB1,MARCKS,HN1,NDC80,TPX2,KIF15,EZH2,TOP2A,MKI67,NASP,H2AFZ,SS18,SMC2,PRC1,KPNA2,HMGN2,HUS1,SAP30,STMN1,ODC1,E2F3,UBE2S,KIF2C,CDKN1B,CBX1,RBM14,CHEK1,POLA2,PLK1,CDC20,KIF23,KATNA1,CUL4A,SMC4,TFDP1,TOP1,SRSF10,RPS6KA5,RACGAP1,SLC7A5,WHSC1,UCK2,KIF22,HIF1A,EFNA5,HSPA8,CDC7,SYNCRIP,H2AFX,MYBL2,PRMT5,SNRPD1,CHMP1A,UPF1,SLC7A1,STAG1,KIF11,BUB1,DR1,NOTCH2,SFPQ,GINS2,AURKA,ORC6,TTK,SMARCC1,DBF4,CASP8AP2,XPO1,PLK4,PDS5B,ORC5,H2AFV,FANCC,CDK4,RAD23B,TROAP,HNRNPU,EWSR1,MCM5,TGFB1,SRSF1,PRIM2,PAPD7,MCM2,CASC5,SRSF2,GSPT1,HIST1H2BK,CENPE,ODF2,SETD8,HMGA1,SLC38A1,LIG3,SLC12A2,CHAF1A,MNAT1,ATRX,E2F4,CDC6,MAD2L1,SUV39H1,CCNF,MTF2,CENPA,ESPL1,G3BP1,PRPF4B,CDC27,CCND1,NEK2,HMGB3,HMMR,HIRA,CKS1B,CTCF,E2F1,TACC3,RBL1,TRA2B,DTYMK,POLQ,CUL1,BARD1,ABL1,ATF5,CCNA2,KPNB1,E2F2,CDK1,SMC1A,BUB3,EGF,NUP50,MCM3,CDC25A,TRAIP,CDKN2C,NUSAP1,KIF20B,MAPK14,TMPO,EXO1,RAD21,CCNB2,WRN,TLE3,PBK,POLE,ARID4A,TNPO2,BRCA2,CDC25B,BCL3,SQLE,MCM6,CDC45,YTHDC1,MEIS1,CKS2,LBR,NUMA1,NCL,PML,SMAD3,MYC,RAD54L,DKC1,FOXN3,PURA,HNRNPD,NUP98,ILF3,RPA2,DMD,NOLC1,FBXO5,MEIS2,CCNT1,RASAL2,INCENP,PTTG1,STIL	0.000188289649084572
HALLMARK_INTERFERON_ALPHA_RESPONSE	UP	3.50166731605127	2381	45	15378	45	3.44043782352088e-09	IRF7,LGALS3BP,PARP14,IFI44,DDX60,RTP4,B2M,GBP2,IFITM3,EIF2AK2,HERC6,IRF9,TAP1,RSAD2,LY6E,IFIT3,DHX58,ISG15,GBP4,SP110,PSMB8,IFIH1,CXCL10,PARP12,UBA7,STAT2,MX1,UBE2L6,IFI35,PARP9,CMPK2,CSF1,BST2,EPSTI1,CD74,LAP3,IRF1,ADAR,TRIM25,TRIM21,SAMD9L,IFIT2,CASP1,PSME1,CCRL2,PSMB9,OGFR,C1S,IFITM2,CASP8,TXNIP,NUB1,GMPR,ISG20,CNP,FAM46A,TRIM26,IRF2,LPAR6,TRIM14,IFITM1,FTSJD2,MOV10,IFI30,CD47,PROCR,ELF1,TRAFD1,NMI,RNF31,NCOA7,IL15,PLSCR1,LAMP3,PSME2,TDRD7,WARS,FAM125A,PNPT1,RIPK2,SLC25A28,TMEM140,PSMA3	1.14521886418473e-07
HALLMARK_INTERFERON_GAMMA_RESPONSE	UP	2.02985949845574	5252	113	15378	113	4.29050051042879e-09	IFIT1,IRF7,GBP6,LGALS3BP,PARP14,IFI44,DDX60,RTP4,XAF1,NLRC5,B2M,ZBP1,DDX58,STAT1,IFITM3,EIF2AK2,HERC6,IRF9,TAP1,OAS2,RSAD2,LY6E,PTPN6,IFIT3,DHX58,ISG15,GBP4,PLA2G4A,TNFSF10,SP110,PSMB8,CD274,TNFAIP2,SERPING1,IFIH1,CXCL10,PARP12,STAT3,STAT2,MX1,CFB,UBE2L6,IFI35,VCAM1,CMPK2,ZNFX1,BST2,CSF2RB,IL10RA,EPSTI1,ICAM1,MX2,TAPBP,PFKP,CD74,LAP3,IRF1,ADAR,SLAMF7,IRF8,TRIM25,IRF5,TRIM21,IFNAR2,SAMHD1,CASP4,LCP2,NCOA3,PIM1,SAMD9L,VAMP5,IFIT2,PML,SSPN,CD40,CASP1,PSME1,NFKB1,PTGS2,CFH,PSMB10,CMKLR1,PSMB9,OGFR,ST8SIA4,RAPGEF6,RIPK1,P2RY14,C1S,IFITM2,SOCS1,CASP8,UPP1,TXNIP,MYD88,IRF4,CIITA,ISG20,TNFAIP6,NOD1,IL18BP,NUP93,PDE4B,TRIM26,CD86,FGL2,PTPN1,IL15RA,IRF2,SOCS3,PSMB2,MVP,TRIM14,GCH1,LATS2,FTSJD2,ARID5B,IFI30,CDKN1A,ST3GAL5,AUTS2,ITGB7,STAT4,FAS,SOD2,BPGM,TNFAIP3,MTHFD2,TRAFD1,NMI,LYSMD2,RNF31,IL15,PLSCR1,NAMPT,EIF4E3,JAK2,PSME2,TDRD7,PELI1,VAMP8,MARCH1,PNP,SRI,PTPN2,CASP3,RBCK1,WARS,CASP7,CD38,BANK1,PNPT1,PSMA2,RIPK2,SLC25A28,TOR1B,HIF1A,ARL4A,CXCL9,NFKBIA,PSMA3,BTG1,ISOC1	1.14521886418473e-07
HALLMARK_MYC_TARGETS_V1	DOWN	1.6654072006161	5936	126	15378	126	4.56279769522894e-09	NME1,EIF3B,H2AFZ,KPNA2,COX5A,CCT5,YWHAQ,PRDX3,NDUFAB1,LSM7,ODC1,HDAC2,RANBP1,PSMA4,C1QBP,SNRPA,PPIA,CLNS1A,CCT4,EIF2S1,AP3S1,CCT7,PSMD8,RUVBL2,PSMA6,PCBP1,TCP1,LSM2,ACP1,EIF4G2,CDC20,RNPS1,RPS2,RPLP0,CCT3,PTGES3,NCBP2,SLC25A3,SRPK1,PSMA7,TFDP1,AIMP2,PABPC4,DHX15,EPRS,SNRPA1,RPL22,HSPD1,UBE2E1,PHB2,GNB2L1,EIF4A1,TXNL4A,ETF1,ORC2,RFC4,SYNCRIP,IFRD1,SNRPD1,SRSF3,PSMB3,TRIM28,PSMA2,IARS,PGK1,CCT2,EIF4E,APEX1,RPL6,HNRNPA2B1,SNRPD3,MRPS18B,PA2G4,EIF1AX,GLO1,RSL1D1,HNRNPC,SMARCC1,CTPS,HDDC2,TUFM,GNL3,RPL34,SF3B3,SET,PWP1,XPO1,MCM7,VDAC1,HNRNPA3,CDK4,YWHAE,RAD23B,COPS5,HNRNPA1,CBX3,SSBP1,DUT,HNRNPU,KARS,MCM5,SERBP1,SRSF1,MCM2,VBP1,ERH,SRSF2,MRPL23,NHP2,NCBP1,GSPT1,CSTF2,RPL14,LDHA,NOP56,HSPE1,PSMD1,EIF2S2,PSMD14,RAN,PSMC4,SSB,TOMM70A,HNRNPR,SRSF7,IMPDH2,EEF1B2,TARDBP,CYC1,EXOSC7,CANX,HDGF,MAD2L1,FAM120A,U2AF1,PSMA1,MRPL9,CNBP,G3BP1,PPM1G,PSMD3,RRM1,ILF2,SRM,STARD7,DDX21,CAD,POLE3,PABPC1,RPS5,TRA2B,DDX18,USP1,CUL1,HSP90AB1,NOP16,PRDX4,GOT2,RPS3,XRCC6,CCNA2,KPNB1,NPM1,SNRPG,PSMD7,BUB3,SNRPB2,EIF4H,PRPF31,VDAC3,NAP1L1,UBE2L3,EIF3J,PHB,MCM4,PSMB2,UBA2,EIF3D,TYMS,POLD2,CDK2,PCNA,MCM6,CDC45,RPL18,SNRPD2,FBL,RRP9,XPOT,RPS6,MYC,HNRNPD,PRPS2,NOLC1,SF3A1,RPS10	1.14521886418473e-07
HALLMARK_OXIDATIVE_PHOSPHORYLATION	DOWN	1.56160313179515	7115	138	15378	138	4.58087545673891e-09	UQCRQ,TOMM22,ATP5F1,COX5A,ACAT1,TIMM10,COX6C,IDH1,GLUD1,ECH1,PRDX3,MRPS11,ATP5J2,NDUFAB1,HCCS,HADHA,TIMM13,ATP5H,NDUFB8,PDP1,ATP5L,ATP5J,BAX,SLC25A5,NDUFB3,SDHD,DLST,MDH1,SLC25A3,MTX2,NDUFS4,NDUFS8,ATP5O,OXA1L,NDUFC2,NDUFA4,NDUFB6,MRPS22,PDHX,GPX4,TIMM8B,POLR2F,ISCU,PHB2,LRPPRC,NDUFV1,AIFM1,MRPS12,UQCRFS1,COX7B,SUCLA2,NDUFA9,ATP6V1H,DLD,NDUFA8,SDHC,IDH2,RHOT1,HADHB,NDUFA5,CYCS,PDHB,NDUFC1,UQCRB,FDX1,BRP44L,ATP5B,NDUFV2,ABCB7,SLC25A4,ATP5C1,NDUFA6,FXN,UQCRC1,NDUFS7,ACADVL,NDUFB2,CASP7,ETFDH,SUPV3L1,HSD17B10,VDAC1,MRPL35,ATP6V0B,MRPS30,ATP5D,COX8A,IDH3A,PMPCA,ISCA1,GRPEL1,TIMM9,SDHB,ACADM,UQCR11,BCKDHA,ATP5G1,COX11,OAT,IMMT,IDH3B,POR,COX4I1,OGDH,NQO2,ATP6V1D,MRPL11,LDHA,UQCRC2,NDUFS3,MGST3,IDH3G,NDUFA3,TIMM50,MDH2,ACAA2,ATP5A1,ATP5E,COX6A1,TOMM70A,DLAT,ECHS1,ATP5G3,ATP6V1F,NDUFS2,NDUFS1,DECR1,CYC1,LDHB,ETFA,AFG3L2,COX7C,ATP5G2,ATP6AP1,COX17,ETFB,COX5B,NDUFB5,CS,BDH2,SLC25A11,TIMM17A,NDUFA2,COX7A2,ATP6V1C1,NNT,SUCLG1,HTRA2,ATP6V1G1,VDAC2,UQCR10,GOT2,COX10,SDHA,OPA1,HSPA9,PDHA1,MRPS15,NDUFA7,ACO2,CPT1A,VDAC3,MFN2,ACADSB,SLC25A12,COX6B1,MRPL34,COX7A2L,PHYH,MAOB,ATP6V1E1,MRPL15,NDUFS6,SLC25A20,NDUFA1,RHOT2,NDUFB4,NDUFB7,SURF1,RETSAT,MTRF1,PDK4,ATP1B1,ECI1,COX15,ALAS1,CYB5R3,TCIRG1,UQCRH,ALDH6A1,MTRR	1.14521886418473e-07
HALLMARK_IL2_STAT5_SIGNALING	UP	2.92454714020824	738	24	15378	24	6.50600887908137e-05	IFITM3,TGM2,GBP4,TNFSF10,NDRG1,CST7,CXCL10,AHNAK,TNFRSF1B,COL6A1,CTSZ,TLR7,CSF1,GPR65,TIAM1,IL10RA,GALM,PLEC,SYNGR2,AKAP2,DHRS3,MYO1E,IRF6,IGF1R,BMPR2,IRF8,DCPS,SCN9A,IKZF2,ENPP1,GABARAPL1,HIPK2,NCOA3,PIM1,MYC,MXD1,FAH,CYFIP1,RHOH,PRKCH,HUWE1,SH3BGRL2,CAPG,ITIH5,RRAGD,PTCH1,HK2,SLC29A2,IL2RA,SHE,APLP1,CISH,SOCS1,CD44,CD48,IKZF4,IRF4,PLAGL1,LRRC8C,COCH,CCNE1,SLC1A5,CAPN3,CD83,CD86,FGL2,IFNGR1,SYT11,IGF2R,NRP1,DENND5A,SLC39A8,LIF,PRNP,PTGER2,ECM1,PRAF2,ENO3,AHCY,P2RX4,GLIPR2,PTH1R,TTC39B,CD81,BATF3,RNH1,MAP3K8,EMP1,PPAP2A,KLF6,RORA,BCL2L1,SNX9,RABGAP1L,P4HA1,AMACR,CCND3,ANXA4,TNFRSF4,LCLAT1,NT5E,PUS1,MAPKAPK2,MYO1C,CDC6,PLSCR1,IL18R1,ITGAV,PHLDA1,SWAP70,GUCY1B3,PENK,TNFRSF18,NFKBIZ,BMP2,NOP2,AGER,PNP,RGS16,XBP1,AHR,NCS1,SPRY4,LRIG1,ICOS,CASP3,PLIN2,ST3GAL4,FURIN,RHOB,SNX14,POU2F1,N6AMT2,SPP1,TRAF1,ITGA6,PDCD2L,GADD45B,ALCAM,IL3RA,GSTO1,NFIL3,CDKN1C,PHTF2,TNFRSF21,IL1RL1,S100A1,SOCS2,CKAP4,PTRH2,BCL2,UCK2,ETV4,GPX4,UMPS,ARL4A,SLC2A3,TWSG1,GPR83,MUC1,TNFSF11,EOMES,MAFF,SMPDL3A,CDC42SE2,WLS,ODC1,HOPX,ADAM19,CCDC164,CCND2	0.000591455352643761
HALLMARK_INFLAMMATORY_RESPONSE	UP	1.60792544109277	6024	97	15378	97	6.93635272552839e-08	IRF7,RTP4,IL1R1,EIF2AK2,LY6E,OSMR,TNFSF10,CYBB,CXCL10,TNFRSF1B,C3AR1,TLR2,CSF1,BST2,IL10RA,KIF1B,ICAM1,TAPBP,C5AR1,SEMA4D,CSF3R,IRF1,RHOG,ATP2B1,CLEC5A,SCARF1,AXL,EMR1,MSR1,NOD2,EBI3,HBEGF,CD14,LCP2,TPBG,MYC,MXD1,SLC1A2,CD40,VIP,SLC31A2,PIK3R5,LDLR,CCRL2,NFKB1,CMKLR1,CD82,P2RX7,BEST1,TACR1,ICAM4,MMP14,SLC7A2,PTAFR,GABBR1,EDN1,TLR3,STAB1,OPRK1,CD48,TACR3,TNFAIP6,ABCA1,IL7R,TLR1,KCNMB2,ITGB3,PDE4B,NMUR1,IL15RA,GNA15,IL1A,GPR183,SLC4A4,ACVR1B,LIF,ABI1,NPFFR2,SLAMF1,ADM,PTPRE,CX3CL1,PTGER2,RELA,ITGA5,RASGRP1,GCH1,IFITM1,HRH1,SPHK1,ADORA2B,IFNGR2,P2RX4,DCBLD2,SERPINE1,EMP3,P2RY2,IL18,CDKN1A,ATP2A2,IRAK2,KLF6,SCN1B,NLRP3,TNFSF15,ADRM1,RNF144B,NMI,SGMS2,IL15,CALCRL,RAF1,SLC11A2,IL18R1,NAMPT,LAMP3,PSEN1,PCDH7,BTG2,GNAI3,RGS16,PTGER4,AHR,APLNR,SRI,ITGB8,PVR,LYN,ATP2C1,CHST2,LPAR1,KCNA3,SLC31A1,AQP9,PLAUR,FZD5,SLC7A1,RIPK2,F3,ACVR2A,PDPN,HIF1A,KCNJ2,CXCL9,GPC3,LCK,NFKBIA,NDP,HAS2,INHBA,MET,PROK2,IFNAR1,CD55	1.15605878758807e-06
HALLMARK_KRAS_SIGNALING_UP	UP	2.1416144721149	1687	39	15378	39	8.38835402832139e-05	ITGB2,IL33,CTSS,IGF2,PSMB8,LAPTM5,CXCL10,DOCK2,PECAM1,TNFRSF1B,CFB,C3AR1,LCP1,MMP11,IL10RA,IKZF1,FCER1G,MAP3K1,F13A1,RBP4,VWA5A,ELTD1,ENG,SNAP25,IRF8,GLRX,TNNT2,PLVAP,NIN,GPNMB,FLT4,HBEGF,ACE,SCG5,CSF2RA,ATG10,PTPRR,PEG3,MAP4K1,BIRC3,TLR8,JUP,PTGS2,CFH,DNMBP,CMKLR1,MAFB,TOR1AIP2,SPARCL1,NAP1L2,FUCA1,CIDEA,PRDM1,CD37,CBL,SEMA3B,IL7R,GUCY1A3,IL2RG,MMP9,ITGA2,F2RL1,PCP4,NRP1,STRN,LIF,USP12,SNAP91,GNG11,PRKG2,ANO1,ETV5,ETS1,TMEM158,DCBLD2,GYPC,PCSK1N,NGF,AKT2,GABRA3,IL1RL2,APOD,HSD11B1,EMP1,TPH1,RBM4,ETV1,RABGAP1L,SCN1B,GPR124,KLF4,SPON1,YRDC,KIF5C,BPGM,TNFAIP3,MMD,LAT2,SLMO2,TSPAN7,BTC,CAB39L,EVI5,HDAC9,AMMECR1,GFPT2,MTMR10,TMEM176A,BTBD3,BMP2,CBR4,SOX9,GALNT3,RGS16,FGF9,MALL,FBXO4,ADAM8,IGFBP3,SCG3,HKDC1,AVL9,CROT,ANGPTL4,RELN,PPP1R15A,SPP1,TRAF1,TMEM176B,KCNN4,ST6GAL1,CDADC1,ID2,LY96,WDR33,PLAUR,PTBP2,TSPAN13,ALDH1A2,PRRX1,ALDH1A3,EPHB2,ADAM17,PTCD2,PLAU,CPE,ETV4,SPRY2,TFPI,SDCCAG8,ERO1L,TMEM100,MPZL2,GADD45G,INHBA,CXCR4,G0S2,ITGBL1,MYCN,HIST1H2BB,PLAT,WNT7A,CCND2,SATB1,CBX8,TRIB2	0.000699029502360116
HALLMARK_IL6_JAK_STAT3_SIGNALING	UP	2.21158142583847	4397	43	15378	43	8.54018050722161e-08	STAT1,IL1R1,IRF9,OSMR,CXCL10,TNFRSF1B,STAT3,STAT2,TLR2,CSF1,CSF2RB,CD36,CSF3R,IRF1,A2M,EBI3,CD14,CSF2RA,PIM1,IL6ST,ITGA4,TNFRSF1A,IL17RA,PIK3R5,PTPN11,CCR1,IL2RA,HMOX1,SOCS1,IL10RB,CD44,MYD88,ACVRL1,IL13RA1,CBL,TYK2,ITGB3,CRLF2,IFNGR1,IL2RG,PTPN1,IL15RA,SOCS3,ACVR1B,IL17RB,CNTFR,IFNGR2,MAP3K8,IL12RB1,FAS,STAM2,LEPR,GRB2,JUN,IL18R1,PTPN2,TGFB1,LTBR,BAK1,CD38,IL3RA,TNFRSF21,TNFRSF12A,CD9,CXCL9,PDGFC,HAX1,IFNAR1	1.22002578674594e-06
